psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H22	R:R:P23	4.58	No	No	0	4	4
2	R:R:A25	R:R:H22	5.85	No	No	0	4	4
3	R:R:P29	R:R:V28	3.53	No	Yes	0	5	6
4	R:R:I275	R:R:V28	3.07	Yes	Yes	0	3	6
5	R:R:A83	R:R:F32	5.55	No	No	0	6	7
6	R:R:F32	R:R:Y282	6.19	No	Yes	0	7	7
7	R:R:I35	R:R:Y282	3.63	No	Yes	0	7	7
8	R:R:F36	R:R:T40	7.78	Yes	No	0	7	6
9	R:R:F36	R:R:V79	7.87	Yes	No	2	7	7
10	R:R:F36	R:R:P80	7.22	Yes	No	2	7	8
11	R:R:C286	R:R:G39	3.92	No	No	0	7	8
12	R:R:L72	R:R:N43	13.73	No	No	0	8	9
13	R:R:N43	R:R:P289	4.89	No	No	0	9	9
14	R:R:A293	R:R:V46	3.39	No	No	0	7	9
15	R:R:F299	R:R:V49	10.49	Yes	No	0	8	7
16	R:R:F299	R:R:L50	4.87	Yes	No	0	8	6
17	R:R:P139	R:R:V57	3.53	No	No	0	2	6
18	R:R:S58	R:R:T60	3.2	No	No	0	8	7
19	R:R:N61	R:R:S58	8.94	No	No	0	7	8
20	R:R:F63	R:R:T59	3.89	Yes	No	3	7	6
21	R:R:D122	R:R:T59	4.34	Yes	No	3	8	6
22	R:R:A142	R:R:T59	5.03	No	No	0	7	6
23	R:R:F63	R:R:V119	3.93	Yes	No	0	7	9
24	R:R:D122	R:R:F63	8.36	Yes	Yes	3	8	7
25	R:R:F63	R:R:I146	3.77	Yes	No	0	7	7
26	R:R:N66	R:R:T115	8.77	No	No	0	9	8
27	R:R:I146	R:R:N66	12.74	No	No	0	7	9
28	R:R:N66	R:R:W150	6.78	No	No	0	9	9
29	R:R:D71	R:R:L67	8.14	Yes	No	0	9	9
30	R:R:L116	R:R:L67	5.54	No	No	0	8	9
31	R:R:D71	R:R:S285	7.36	Yes	No	0	9	9
32	R:R:D71	R:R:N288	6.73	Yes	No	0	9	9
33	R:R:L72	R:R:L76	6.92	No	No	0	8	4
34	R:R:C78	R:R:F74	4.19	Yes	Yes	1	7	7
35	R:R:F74	R:R:I105	3.77	Yes	No	1	7	5
36	R:R:F74	R:R:T108	9.08	Yes	No	0	7	8
37	R:R:F74	R:R:M109	4.98	Yes	Yes	1	7	7
38	R:R:F74	R:R:W249	5.01	Yes	Yes	1	7	9
39	R:R:F74	R:R:S285	7.93	Yes	No	0	7	9
40	R:R:I75	R:R:V79	4.61	No	No	0	7	7
41	R:R:I75	R:R:S285	3.1	No	No	0	7	9
42	R:R:C77	R:R:V101	3.42	No	No	0	4	5
43	R:R:C77	R:R:L104	4.76	No	No	0	4	5
44	R:R:C78	R:R:Q82	6.1	Yes	Yes	1	7	6
45	R:R:C78	R:R:I105	9.82	Yes	No	1	7	5
46	R:R:C78	R:R:Y282	6.72	Yes	Yes	1	7	7
47	R:R:P80	R:R:V79	5.3	No	No	2	8	7
48	R:R:F81	R:R:F93	6.43	No	Yes	0	6	6
49	R:R:F81	R:R:V101	18.35	No	No	0	6	5
50	R:R:H278	R:R:Q82	7.42	Yes	Yes	1	5	6
51	R:R:Q82	R:R:Y282	5.64	Yes	Yes	1	6	7
52	L:L:Y9	R:R:Q82	6.76	Yes	Yes	1	0	6
53	R:R:I85	R:R:W91	4.7	No	Yes	0	5	8
54	L:L:N5	R:R:I85	5.66	No	No	0	0	5
55	L:L:Y9	R:R:I85	4.84	Yes	No	0	0	5
56	R:R:Y271	R:R:Y86	4.96	No	Yes	1	3	5
57	R:R:R274	R:R:Y86	6.17	Yes	Yes	1	3	5
58	R:R:I275	R:R:Y86	3.63	Yes	Yes	1	3	5
59	R:R:H278	R:R:Y86	9.8	Yes	Yes	1	5	5
60	L:L:S6	R:R:Y86	6.36	No	Yes	0	0	5
61	L:L:N5	R:R:G90	5.09	No	No	0	0	5
62	R:R:F93	R:R:W91	18.04	Yes	Yes	0	6	8
63	R:R:C98	R:R:W91	3.92	No	Yes	1	9	8
64	R:R:Q166	R:R:W91	5.48	No	Yes	1	5	8
65	R:R:C175	R:R:W91	14.37	No	Yes	1	9	8
66	R:R:F93	R:R:L97	4.87	Yes	No	0	6	5
67	R:R:C98	R:R:Q166	6.1	No	No	1	9	5
68	R:R:C175	R:R:C98	7.28	No	No	1	9	9
69	R:R:K99	R:R:R165	3.71	No	Yes	0	6	4
70	R:R:H102	R:R:Y164	18.51	No	Yes	1	4	5
71	R:R:C175	R:R:H102	4.42	No	No	1	9	4
72	L:L:Y9	R:R:H102	6.53	Yes	No	1	0	4
73	R:R:F103	R:R:L104	3.65	Yes	No	0	6	5
74	R:R:F103	R:R:L107	6.09	Yes	Yes	4	6	4
75	R:R:F103	R:R:S157	5.28	Yes	No	4	6	7
76	R:R:F103	R:R:L161	12.18	Yes	No	0	6	5
77	R:R:F106	R:R:M109	8.71	Yes	Yes	1	4	7
78	R:R:F106	R:R:H110	4.53	Yes	Yes	1	4	6
79	R:R:F106	R:R:Y160	35.07	Yes	Yes	1	4	4
80	R:R:F106	R:R:Y164	3.09	Yes	Yes	1	4	5
81	R:R:L107	R:R:W150	4.56	Yes	No	0	4	9
82	R:R:L107	R:R:S153	4.5	Yes	No	0	4	8
83	R:R:L107	R:R:L154	6.92	Yes	No	0	4	4
84	R:R:L107	R:R:S157	6.01	Yes	No	4	4	7
85	R:R:H110	R:R:M109	6.57	Yes	Yes	1	6	7
86	R:R:M109	R:R:W249	8.14	Yes	Yes	1	7	9
87	R:R:F156	R:R:H110	3.39	Yes	Yes	0	4	6
88	R:R:H110	R:R:S195	6.97	Yes	No	0	6	6
89	R:R:A111	R:R:W150	3.89	No	No	0	6	9
90	R:R:A111	R:R:S153	3.42	No	No	0	6	8
91	R:R:F245	R:R:S113	3.96	No	No	0	9	7
92	R:R:F114	R:R:I149	7.54	No	No	0	6	7
93	R:R:F114	R:R:F156	4.29	No	Yes	0	6	4
94	R:R:I149	R:R:T115	3.04	No	No	0	7	8
95	R:R:L116	R:R:Y292	5.86	No	Yes	0	8	9
96	R:R:R123	R:R:V119	6.54	No	No	0	9	9
97	R:R:L203	R:R:S120	3	No	No	0	8	9
98	R:R:S120	R:R:T206	7.99	No	Yes	0	9	7
99	R:R:S120	R:R:Y207	11.45	No	Yes	0	9	9
100	R:R:D122	R:R:R137	11.91	Yes	No	0	8	6
101	R:R:R123	R:R:Y292	4.12	No	Yes	0	9	9
102	R:R:R128	R:R:Y124	4.12	No	Yes	0	7	8
103	R:R:T206	R:R:Y124	3.75	Yes	Yes	0	7	8
104	R:R:R209	R:R:Y124	15.43	No	Yes	0	4	8
105	R:R:T210	R:R:Y124	6.24	No	Yes	0	8	8
106	R:R:A126	R:R:R137	6.91	No	No	0	8	6
107	R:R:I127	R:R:T210	4.56	No	No	0	8	8
108	R:R:R128	R:R:Y129	13.38	No	No	0	7	6
109	R:R:R128	R:R:Y213	16.46	No	No	0	7	5
110	R:R:H132	R:R:Y129	4.36	No	No	0	5	6
111	R:R:N141	R:R:T138	8.77	No	No	0	4	7
112	R:R:L148	R:R:L152	5.54	No	No	0	3	4
113	R:R:F156	R:R:F194	7.5	Yes	Yes	0	4	4
114	R:R:G158	R:R:P159	4.06	No	No	0	4	7
115	R:R:M187	R:R:P159	8.39	No	No	0	5	7
116	R:R:Y160	R:R:Y163	4.96	Yes	Yes	1	4	4
117	R:R:M187	R:R:Y160	5.99	No	Yes	1	5	4
118	R:R:T191	R:R:Y160	4.99	No	Yes	0	5	4
119	R:R:R165	R:R:S162	5.27	Yes	No	1	4	4
120	R:R:S162	R:R:W179	7.41	No	Yes	1	4	4
121	R:R:Y163	R:R:Y164	14.89	Yes	Yes	1	4	5
122	R:R:P177	R:R:Y163	5.56	No	Yes	1	4	4
123	R:R:W179	R:R:Y163	10.61	Yes	Yes	1	4	4
124	R:R:R184	R:R:Y163	7.2	Yes	Yes	1	4	4
125	R:R:M187	R:R:Y163	3.59	No	Yes	1	5	4
126	R:R:D188	R:R:Y163	5.75	No	Yes	0	5	4
127	R:R:P177	R:R:Y164	8.34	No	Yes	1	4	5
128	L:L:Y9	R:R:Y164	8.94	Yes	Yes	1	0	5
129	R:R:R165	R:R:W179	6	Yes	Yes	1	4	4
130	R:R:S167	R:R:V174	3.23	No	No	0	1	4
131	R:R:H176	R:R:V174	22.14	Yes	No	0	4	4
132	R:R:H176	R:R:P177	3.05	Yes	No	0	4	4
133	L:L:G8	R:R:H176	4.77	No	Yes	0	0	4
134	L:L:Y9	R:R:H176	4.36	Yes	Yes	0	0	4
135	R:R:R184	R:R:W179	5	Yes	Yes	1	4	4
136	R:R:R183	R:R:S180	5.27	No	No	0	2	4
137	R:R:R184	R:R:W260	5	Yes	Yes	0	4	4
138	L:L:G12	R:R:R184	3	No	Yes	0	0	4
139	R:R:R185	R:R:W260	12	No	Yes	0	3	4
140	R:R:D188	R:R:W260	11.17	No	Yes	0	5	4
141	R:R:S195	R:R:T191	3.2	No	No	0	6	5
142	R:R:F192	R:R:Y196	8.25	No	Yes	5	5	8
143	R:R:F192	R:R:H253	15.84	No	No	5	5	8
144	R:R:F194	R:R:V193	3.93	Yes	No	0	4	4
145	R:R:V200	R:R:Y196	3.79	No	Yes	0	6	8
146	R:R:M250	R:R:Y196	11.97	No	Yes	0	5	8
147	R:R:H253	R:R:Y196	11.98	No	Yes	5	8	8
148	R:R:L197	R:R:L201	4.15	No	No	0	4	3
149	R:R:F245	R:R:P199	5.78	No	No	0	9	8
150	R:R:F245	R:R:L203	8.53	No	No	0	9	8
151	R:R:I238	R:R:Y207	7.25	No	Yes	0	7	9
152	R:R:V241	R:R:Y207	3.79	No	Yes	0	8	9
153	R:R:L211	R:R:T235	5.9	No	No	0	4	6
154	R:R:I238	R:R:L211	9.99	No	No	0	7	4
155	R:R:R216	R:R:Y213	16.46	No	No	0	5	5
156	R:R:T235	R:R:W215	8.49	No	No	0	6	4
157	R:R:R216	R:R:V218	5.23	No	No	0	5	5
158	R:R:R229	R:R:S225	6.59	No	No	0	4	3
159	R:R:G226	R:R:R229	7.51	No	No	0	3	4
160	R:R:R228	R:R:R232	5.33	No	Yes	0	3	4
161	R:R:R229	R:R:R232	5.33	No	Yes	0	4	4
162	R:R:R232	R:R:R236	4.26	Yes	No	0	4	6
163	R:R:K233	R:R:R236	3.71	No	No	0	7	6
164	R:R:I238	R:R:V234	3.07	No	No	0	7	7
165	R:R:M237	R:R:V295	6.09	No	No	0	8	6
166	R:R:V241	R:R:Y292	8.83	No	Yes	0	8	9
167	R:R:C248	R:R:L244	3.17	No	No	0	8	7
168	R:R:L244	R:R:V287	4.47	No	No	0	7	6
169	R:R:C248	R:R:N284	11.02	No	No	0	8	9
170	R:R:H252	R:R:W249	4.23	No	Yes	0	7	9
171	R:R:N284	R:R:W249	6.78	No	Yes	0	9	9
172	R:R:M250	R:R:P251	3.35	No	No	0	5	9
173	R:R:H252	R:R:I256	5.3	No	No	0	7	6
174	R:R:H252	R:R:R274	6.77	No	Yes	0	7	3
175	R:R:F264	R:R:L255	7.31	Yes	No	0	5	4
176	R:R:L255	R:R:R274	9.72	No	Yes	0	4	3
177	R:R:F261	R:R:L257	3.65	No	No	0	4	6
178	R:R:F264	R:R:V259	10.49	Yes	No	0	5	4
179	R:R:F264	R:R:T270	5.19	Yes	Yes	0	5	4
180	L:L:L10	R:R:F264	3.65	No	Yes	0	0	5
181	L:L:W2	R:R:L266	12.53	Yes	No	0	0	1
182	L:L:L11	R:R:L266	4.15	No	No	0	0	1
183	R:R:T267	R:R:T270	4.71	No	Yes	0	3	4
184	L:L:W2	R:R:T270	6.06	Yes	Yes	0	0	4
185	R:R:I275	R:R:Y271	13.3	Yes	No	1	3	3
186	L:L:W2	R:R:Y271	6.75	Yes	No	0	0	3
187	R:R:R274	R:R:S277	5.27	Yes	No	0	3	6
188	R:R:H278	R:R:R274	18.05	Yes	Yes	1	5	3
189	L:L:L10	R:R:R274	7.29	No	Yes	0	0	3
190	R:R:H278	R:R:Y282	5.44	Yes	Yes	1	5	7
191	R:R:S281	R:R:Y282	3.82	No	Yes	0	7	7
192	R:R:N284	R:R:N288	10.9	No	No	0	9	9
193	R:R:N288	R:R:Y292	3.49	No	Yes	0	9	9
194	R:R:A293	R:R:F299	5.55	No	Yes	0	7	8
195	R:R:F299	R:R:L294	4.87	Yes	No	0	8	6
196	R:R:F303	R:R:L294	4.87	No	No	0	7	6
197	L:L:S6	L:L:T3	3.2	No	No	0	0	0
198	L:L:G12	L:L:P13	4.06	No	No	0	0	0
199	R:R:L47	R:R:V69	2.98	No	No	0	7	6
200	R:R:L88	R:R:V92	2.98	No	No	0	4	3
201	R:R:L276	R:R:V280	2.98	No	No	0	6	8
202	R:R:L37	R:R:T40	2.95	No	No	0	5	6
203	R:R:L88	R:R:T84	2.95	No	No	0	4	3
204	R:R:L121	R:R:T206	2.95	No	Yes	0	6	7
205	R:R:L214	R:R:T210	2.95	No	No	0	7	8
206	R:R:L239	R:R:T235	2.95	No	No	0	5	6
207	R:R:D71	R:R:S112	2.94	Yes	No	0	9	9
208	R:R:I64	R:R:L50	2.85	No	No	0	8	6
209	R:R:I275	R:R:L279	2.85	Yes	No	0	3	5
210	R:R:Q168	R:R:T173	2.83	No	No	0	3	5
211	R:R:H253	R:R:S195	2.79	No	No	0	8	6
212	R:R:L279	R:R:L31	2.77	No	No	0	5	4
213	R:R:L294	R:R:L45	2.77	No	No	0	6	6
214	R:R:L50	R:R:L65	2.77	No	No	0	6	6
215	R:R:L51	R:R:L65	2.77	No	No	0	4	6
216	R:R:L143	R:R:L62	2.77	No	No	0	3	5
217	R:R:A145	R:R:F63	2.77	No	Yes	0	5	7
218	R:R:L96	R:R:L97	2.77	No	No	0	1	5
219	L:L:L4	R:R:L172	2.77	No	No	0	0	1
220	R:R:A242	R:R:Y207	2.67	No	Yes	0	8	9
221	R:R:R137	R:R:S133	2.64	No	No	0	6	6
222	R:R:F93	R:R:V92	2.62	Yes	No	0	6	3
223	R:R:V291	R:R:Y292	2.52	No	Yes	0	8	9
224	R:R:I306	R:R:R52	2.51	No	No	0	5	4
225	R:R:K297	R:R:R300	2.48	No	No	0	4	8
226	R:R:F36	R:R:L76	2.44	Yes	No	0	7	4
227	R:R:F114	R:R:L152	2.44	No	No	0	6	4
228	R:R:F156	R:R:L155	2.44	Yes	No	0	4	4
229	R:R:F194	R:R:L198	2.44	Yes	No	0	4	5
230	R:R:L131	R:R:R134	2.43	No	No	0	6	4
231	R:R:K231	R:R:W215	2.32	No	No	0	7	4
232	R:R:F303	R:R:R300	2.14	No	No	0	7	8
233	R:R:G53	R:R:G54	2.11	No	No	0	5	6
234	R:R:F261	R:R:W260	2	No	Yes	0	4	4
235	R:R:A223	R:R:G224	1.95	No	No	0	2	3
236	R:R:A181	R:R:P182	1.87	No	No	0	3	1
237	R:R:G39	R:R:V38	1.84	No	No	0	8	6
238	R:R:G42	R:R:V41	1.84	No	No	0	7	4
239	R:R:G302	R:R:V49	1.84	No	No	0	5	7
240	R:R:G53	R:R:T305	1.82	No	No	0	5	3
241	R:R:G302	R:R:T305	1.82	No	No	0	5	3
242	R:R:A111	R:R:A70	1.79	No	No	0	6	8
243	R:R:P182	R:R:S180	1.78	No	No	0	1	4
244	R:R:P289	R:R:V46	1.77	No	No	0	9	9
245	R:R:P251	R:R:V280	1.77	No	No	0	9	8
246	R:R:G39	R:R:I75	1.76	No	No	0	8	7
247	R:R:P139	R:R:T138	1.75	No	No	0	2	7
248	R:R:P265	R:R:T270	1.75	No	Yes	0	3	4
249	R:R:G68	R:R:L67	1.71	No	No	0	8	9
250	R:R:C73	R:R:V69	1.71	No	No	0	7	6
251	R:R:G90	R:R:L172	1.71	No	No	0	5	1
252	R:R:G94	R:R:L97	1.71	No	No	0	7	5
253	R:R:G151	R:R:L154	1.71	No	No	0	4	4
254	R:R:G204	R:R:L203	1.71	No	No	0	4	8
255	R:R:A25	R:R:V26	1.7	No	No	0	4	6
256	R:R:A117	R:R:V202	1.7	No	No	0	7	6
257	R:R:C73	R:R:T108	1.69	No	No	0	7	8
258	R:R:A269	R:R:T267	1.68	No	No	0	2	3
259	R:R:G54	R:R:Q55	1.64	No	No	0	6	6
260	R:R:C307	R:R:I306	1.64	No	No	0	6	5
261	R:R:A118	R:R:I149	1.62	No	No	0	7	7
262	R:R:T40	R:R:V41	1.59	No	No	0	6	4
263	R:R:T44	R:R:V41	1.59	No	No	0	4	4
264	R:R:T206	R:R:V202	1.59	Yes	No	0	7	6
265	R:R:A142	R:R:L62	1.58	No	No	0	7	5
266	L:L:L4	R:R:A170	1.58	No	No	0	0	2
267	R:R:I27	R:R:V28	1.54	No	Yes	0	5	6
268	R:R:I189	R:R:V193	1.54	No	No	0	5	4
269	R:R:M237	R:R:V291	1.52	No	No	0	8	8
270	R:R:L34	R:R:V38	1.49	No	No	0	5	6
271	R:R:L169	R:R:V174	1.49	No	No	0	2	4
272	R:R:L197	R:R:V193	1.49	No	No	0	4	4
273	R:R:D122	R:R:T60	1.45	Yes	No	0	8	7
274	R:R:E24	R:R:V28	1.43	No	Yes	0	4	6
275	R:R:Q166	R:R:T173	1.42	No	No	0	5	5
276	R:R:C190	R:R:F194	1.4	No	Yes	0	3	4
277	R:R:C258	R:R:F264	1.4	No	Yes	0	4	5
278	R:R:P130	R:R:Y129	1.39	No	No	0	8	6
279	R:R:H298	R:R:S296	1.39	No	No	0	5	8
280	R:R:A48	R:R:R52	1.38	No	No	0	3	4
281	R:R:L125	R:R:L136	1.38	No	No	0	5	3
282	R:R:A178	R:R:R165	1.38	No	Yes	0	4	4
283	R:R:L136	R:R:N141	1.37	No	No	0	3	4
284	R:R:D89	R:R:L88	1.36	No	No	0	4	4
285	R:R:C246	R:R:Y196	1.34	No	Yes	0	5	8
286	R:R:F299	R:R:S296	1.32	Yes	No	0	8	8
287	L:L:A7	L:L:W2	1.3	No	Yes	0	0	0
288	R:R:H132	R:R:L131	1.29	No	No	0	5	6
289	R:R:R140	R:R:T138	1.29	No	No	0	4	7
290	R:R:R268	R:R:T267	1.29	No	No	0	1	3
291	R:R:L51	R:R:R52	1.21	No	No	0	4	4
292	R:R:L125	R:R:Y124	1.17	No	Yes	0	5	8
293	R:R:E135	R:R:R134	1.16	No	No	0	3	4
294	R:R:F303	R:R:R304	1.07	No	No	0	7	4
295	R:R:R183	R:R:W179	1	No	Yes	0	2	4
296	R:R:R232	R:R:W215	1	Yes	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V28	2.3925	4	0	6
2	R:R:F36	6.3275	4	2	7
3	R:R:F63	4.544	5	3	7
4	R:R:D71	6.2925	4	0	9
5	R:R:F74	5.82667	6	1	7
6	R:R:C78	6.7075	4	1	7
7	R:R:Q82	6.48	4	1	6
8	R:R:Y86	6.184	5	1	5
9	R:R:W91	9.302	5	1	8
10	R:R:F93	7.99	4	0	6
11	R:R:F103	6.8	4	4	6
12	R:R:F106	12.85	4	1	4
13	R:R:L107	5.616	5	4	4
14	R:R:M109	7.1	4	1	7
15	R:R:H110	5.365	4	1	6
16	R:R:D122	6.515	4	3	8
17	R:R:Y124	6.142	5	0	8
18	R:R:F156	4.405	4	0	4
19	R:R:Y160	12.7525	4	1	4
20	R:R:Y163	7.50857	7	1	4
21	R:R:Y164	10.754	5	1	5
22	R:R:R165	4.09	4	1	4
23	R:R:H176	8.58	4	0	4
24	R:R:W179	6.004	5	1	4
25	R:R:R184	5.05	4	1	4
26	R:R:F194	3.8175	4	0	4
27	R:R:Y196	7.466	5	5	8
28	R:R:T206	4.07	4	0	7
29	R:R:Y207	6.29	4	0	9
30	R:R:R232	3.98	4	0	4
31	R:R:W249	6.04	4	1	9
32	R:R:W260	7.5425	4	0	4
33	R:R:F264	5.608	5	0	5
34	R:R:T270	4.4275	4	0	4
35	R:R:R274	8.87833	6	1	3
36	R:R:I275	5.7125	4	1	3
37	R:R:H278	10.1775	4	1	5
38	R:R:Y282	5.24	6	1	7
39	R:R:Y292	4.964	5	0	9
40	R:R:F299	5.42	5	0	8
41	L:L:W2	6.66	4	0	0
42	L:L:Y9	6.286	5	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H278	R:R:Y86	16.2691	9.8	Yes	Yes	1	5	5
2	R:R:I275	R:R:Y86	13.442	3.63	Yes	Yes	1	3	5
3	R:R:F36	R:R:V79	56.1273	7.87	Yes	No	2	7	7
4	R:R:I75	R:R:V79	59.1447	4.61	No	No	0	7	7
5	R:R:I75	R:R:S285	66.0584	3.1	No	No	0	7	9
6	R:R:F74	R:R:S285	64.5677	7.93	Yes	No	0	7	9
7	R:R:C78	R:R:F74	42.6699	4.19	Yes	Yes	1	7	7
8	R:R:C78	R:R:Q82	31.8444	6.1	Yes	Yes	1	7	6
9	R:R:H278	R:R:Q82	19.4099	7.42	Yes	Yes	1	5	6
10	R:R:C78	R:R:Y282	11.0517	6.72	Yes	Yes	1	7	7
11	R:R:F74	R:R:W249	24.7558	5.01	Yes	Yes	1	7	9
12	R:R:H252	R:R:W249	34.2243	4.23	No	Yes	0	7	9
13	R:R:H252	R:R:R274	32.6103	6.77	No	Yes	0	7	3
14	R:R:R274	R:R:Y86	13.9149	6.17	Yes	Yes	1	3	5
15	R:R:L72	R:R:L76	46.0522	6.92	No	No	0	8	4
16	R:R:F36	R:R:L76	47.5481	2.44	Yes	No	0	7	4
17	R:R:L72	R:R:N43	44.5461	13.73	No	No	0	8	9
18	R:R:N43	R:R:P289	43.0297	4.89	No	No	0	9	9
19	R:R:A293	R:R:V46	39.9661	3.39	No	No	0	7	9
20	R:R:P289	R:R:V46	41.503	1.77	No	No	0	9	9
21	R:R:A293	R:R:F299	38.4188	5.55	No	Yes	0	7	8
22	R:R:F299	R:R:V49	10.5377	10.49	Yes	No	0	8	7
23	R:R:F299	R:R:L50	13.9663	4.87	Yes	No	0	8	6
24	R:R:L125	R:R:L136	11.4784	1.38	No	No	0	5	3
25	R:R:L125	R:R:Y124	13.37	1.17	No	Yes	0	5	8
26	R:R:T206	R:R:Y124	40.3824	3.75	Yes	Yes	0	7	8
27	R:R:S120	R:R:T206	47.2294	7.99	No	Yes	0	9	7
28	R:R:S120	R:R:Y207	57.1913	11.45	No	Yes	0	9	9
29	R:R:V241	R:R:Y207	81.7672	3.79	No	Yes	0	8	9
30	R:R:V241	R:R:Y292	83.222	8.83	No	Yes	0	8	9
31	R:R:N288	R:R:Y292	100	3.49	No	Yes	0	9	9
32	R:R:N284	R:R:N288	71.2553	10.9	No	No	0	9	9
33	R:R:N284	R:R:W249	73.8049	6.78	No	Yes	0	9	9
34	R:R:R123	R:R:Y292	30.2046	4.12	No	Yes	0	9	9
35	R:R:R123	R:R:V119	28.7345	6.54	No	No	0	9	9
36	R:R:F63	R:R:V119	27.4648	3.93	Yes	No	0	7	9
37	R:R:D122	R:R:F63	14.3158	8.36	Yes	Yes	3	8	7
38	R:R:F63	R:R:I146	18.0117	3.77	Yes	No	0	7	7
39	R:R:N66	R:R:T115	18.3972	8.77	No	No	0	9	8
40	R:R:I149	R:R:T115	18.9884	3.04	No	No	0	7	8
41	R:R:F114	R:R:I149	20.4688	7.54	No	No	0	6	7
42	R:R:F114	R:R:F156	24.3395	4.29	No	Yes	0	6	4
43	R:R:F156	R:R:H110	35.6328	3.39	Yes	Yes	0	4	6
44	R:R:H110	R:R:M109	27.2026	6.57	Yes	Yes	1	6	7
45	R:R:M109	R:R:W249	53.3104	8.14	Yes	Yes	1	7	9
46	R:R:N66	R:R:W150	18.5566	6.78	No	No	0	9	9
47	R:R:D71	R:R:S285	37.3805	7.36	Yes	No	0	9	9
48	R:R:D71	R:R:N288	33.3299	6.73	Yes	No	0	9	9
49	R:R:F81	R:R:F93	10.5171	6.43	No	Yes	0	6	6
50	R:R:F93	R:R:W91	28.6933	18.04	Yes	Yes	0	6	8
51	R:R:I85	R:R:W91	28.8064	4.7	No	Yes	0	5	8
52	L:L:Y9	R:R:I85	40.2334	4.84	Yes	No	0	0	5
53	L:L:Y9	R:R:Q82	42.5722	6.76	Yes	Yes	1	0	6
54	L:L:N5	R:R:I85	11.1494	5.66	No	No	0	0	5
55	R:R:C175	R:R:H102	14.213	4.42	No	No	1	9	4
56	R:R:W179	R:R:Y163	21.7385	10.61	Yes	Yes	1	4	4
57	R:R:Y163	R:R:Y164	33.0112	14.89	Yes	Yes	1	4	5
58	L:L:Y9	R:R:Y164	24.9512	8.94	Yes	Yes	1	0	5
59	R:R:L107	R:R:W150	12.6812	4.56	Yes	No	0	4	9
60	R:R:F106	R:R:M109	53.7781	8.71	Yes	Yes	1	4	7
61	R:R:F106	R:R:Y164	48.9874	3.09	Yes	Yes	1	4	5
62	R:R:F106	R:R:Y160	25.1002	35.07	Yes	Yes	1	4	4
63	R:R:Y160	R:R:Y163	21.8978	4.96	Yes	Yes	1	4	4
64	R:R:H110	R:R:S195	14.6602	6.97	Yes	No	0	6	6
65	R:R:R128	R:R:Y124	18.9164	4.12	No	Yes	0	7	8
66	R:R:R128	R:R:Y129	11.5606	13.38	No	No	0	7	6
67	R:R:F156	R:R:F194	11.3653	7.5	Yes	Yes	0	4	4
68	L:L:Y9	R:R:H176	10.7125	4.36	Yes	Yes	0	0	4
69	R:R:R184	R:R:Y163	16.8603	7.2	Yes	Yes	1	4	4
70	R:R:D188	R:R:Y163	11.9513	5.75	No	Yes	0	5	4
71	R:R:H253	R:R:S195	13.8275	2.79	No	No	0	8	6
72	R:R:H253	R:R:Y196	10.7896	11.98	No	Yes	5	8	8
73	R:R:I238	R:R:Y207	26.2465	7.25	No	Yes	0	7	9
74	R:R:I238	R:R:L211	22.6689	9.99	No	No	0	7	4
75	R:R:L211	R:R:T235	20.8235	5.9	No	No	0	4	6
76	R:R:T235	R:R:W215	17.1019	8.49	No	No	0	6	4
77	R:R:R232	R:R:W215	13.442	1	Yes	No	0	4	4
78	R:R:F264	R:R:L255	10.697	7.31	Yes	No	0	5	4
79	R:R:L255	R:R:R274	11.9461	9.72	No	Yes	0	4	3
80	L:L:L10	R:R:F264	10.7022	3.65	No	Yes	0	0	5
81	L:L:L10	R:R:R274	11.9358	7.29	No	Yes	0	0	3
82	R:R:F264	R:R:T270	13.4574	5.19	Yes	Yes	0	5	4
83	R:R:F299	R:R:L294	10.5428	4.87	Yes	No	0	8	6
84	R:R:F93	R:R:V92	10.5223	2.62	Yes	No	0	6	3
85	R:R:L50	R:R:L65	10.5428	2.77	No	No	0	6	6
86	R:R:F74	R:R:M109	27.8143	4.98	Yes	Yes	1	7	7
87	R:R:I146	R:R:N66	17.7855	12.74	No	No	0	7	9
88	R:R:Y271	R:R:Y86	11.3499	4.96	No	Yes	1	3	5
89	R:R:H102	R:R:Y164	13.9766	18.51	No	Yes	1	4	5
90	R:R:F106	R:R:H110	19.4562	4.53	Yes	Yes	1	4	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:C78	R:R:Q82	6.1	1	Yes	Yes	7	6	2	1
R:R:C78	R:R:Y282	6.72	1	Yes	Yes	7	7	2	2
R:R:H278	R:R:Q82	7.42	1	Yes	Yes	5	6	2	1
R:R:Q82	R:R:Y282	5.64	1	Yes	Yes	6	7	1	2
L:L:Y9	R:R:Q82	6.76	1	Yes	Yes	0	6	0	1
R:R:I85	R:R:W91	4.7	0	No	Yes	5	8	1	2
L:L:N5	R:R:I85	5.66	0	No	No	0	5	0	1
L:L:Y9	R:R:I85	4.84	1	Yes	No	0	5	0	1
R:R:Y271	R:R:Y86	4.96	1	No	Yes	3	5	1	1
R:R:R274	R:R:Y86	6.17	1	Yes	Yes	3	5	1	1
R:R:I275	R:R:Y86	3.63	1	Yes	Yes	3	5	2	1
R:R:H278	R:R:Y86	9.8	1	Yes	Yes	5	5	2	1
L:L:S6	R:R:Y86	6.36	0	No	Yes	0	5	0	1
L:L:N5	R:R:G90	5.09	0	No	No	0	5	0	1
R:R:C175	R:R:W91	14.37	1	No	Yes	9	8	2	2
R:R:H102	R:R:Y164	18.51	1	No	Yes	4	5	1	1
R:R:C175	R:R:H102	4.42	1	No	No	9	4	2	1
L:L:Y9	R:R:H102	6.53	1	Yes	No	0	4	0	1
R:R:F106	R:R:Y164	3.09	1	Yes	Yes	4	5	2	1
R:R:Y163	R:R:Y164	14.89	1	Yes	Yes	4	5	2	1
R:R:P177	R:R:Y163	5.56	1	No	Yes	4	4	2	2
R:R:W179	R:R:Y163	10.61	1	Yes	Yes	4	4	2	2
R:R:R184	R:R:Y163	7.2	1	Yes	Yes	4	4	1	2
R:R:P177	R:R:Y164	8.34	1	No	Yes	4	5	2	1
L:L:Y9	R:R:Y164	8.94	1	Yes	Yes	0	5	0	1
R:R:H176	R:R:V174	22.14	0	Yes	No	4	4	1	2
R:R:H176	R:R:P177	3.05	0	Yes	No	4	4	1	2
L:L:G8	R:R:H176	4.77	0	No	Yes	0	4	0	1
L:L:Y9	R:R:H176	4.36	1	Yes	Yes	0	4	0	1
R:R:R184	R:R:W179	5	1	Yes	Yes	4	4	1	2
R:R:R184	R:R:W260	5	1	Yes	Yes	4	4	1	2
L:L:G12	R:R:R184	3	0	No	Yes	0	4	0	1
R:R:H252	R:R:R274	6.77	0	No	Yes	7	3	2	1
R:R:F264	R:R:L255	7.31	0	Yes	No	5	4	1	2
R:R:L255	R:R:R274	9.72	0	No	Yes	4	3	2	1
R:R:F264	R:R:V259	10.49	0	Yes	No	5	4	1	2
R:R:F264	R:R:T270	5.19	0	Yes	Yes	5	4	1	1
L:L:L10	R:R:F264	3.65	0	No	Yes	0	5	0	1
L:L:W2	R:R:L266	12.53	0	Yes	No	0	1	0	1
L:L:L11	R:R:L266	4.15	0	No	No	0	1	0	1
R:R:T267	R:R:T270	4.71	0	No	Yes	3	4	2	1
L:L:W2	R:R:T270	6.06	0	Yes	Yes	0	4	0	1
R:R:I275	R:R:Y271	13.3	1	Yes	No	3	3	2	1
L:L:W2	R:R:Y271	6.75	0	Yes	No	0	3	0	1
R:R:R274	R:R:S277	5.27	1	Yes	No	3	6	1	2
R:R:H278	R:R:R274	18.05	1	Yes	Yes	5	3	2	1
L:L:L10	R:R:R274	7.29	0	No	Yes	0	3	0	1
R:R:H278	R:R:Y282	5.44	1	Yes	Yes	5	7	2	2
L:L:L4	R:R:L172	2.77	0	No	No	0	1	0	1
R:R:P265	R:R:T270	1.75	0	No	Yes	3	4	2	1
R:R:G90	R:R:L172	1.71	0	No	No	5	1	1	1
L:L:L4	R:R:A170	1.58	0	No	No	0	2	0	1
R:R:C258	R:R:F264	1.4	0	No	Yes	4	5	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WQ4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3
Number of Linked Nodes	267
Number of Links	296
Number of Hubs	42
Number of Links mediated by Hubs	152
Number of Communities	5
Number of Nodes involved in Communities	41
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	91
Number Of Links MetaPath	90
Number of Shortest Paths	51977
Length Of Smallest Path	3
Average Path Length	13.6052
Length of Longest Path	31
Minimum Path Strength	1.275
Average Path Strength	6.47141
Maximum Path Strength	21.89
Minimum Path Correlation	0.7
Average Path Correlation	0.936019
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	56.3503
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.5227
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • cellular response to nitrogen compound • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • skeletal system development • bone development • response to pH • cellular response to pH • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • hormone activity • neuropeptide hormone activity • neuropeptide activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • galanin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • galanin receptor binding • neuropeptide receptor binding • type 2 galanin receptor binding • type 1 galanin receptor binding • type 3 galanin receptor binding • positive regulation of steroid hormone secretion • regulation of glucocorticoid secretion • positive regulation of cortisol secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • cortisol secretion • positive regulation of corticosteroid hormone secretion • lipid transport • regulation of corticosteroid hormone secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • regulation of cortisol secretion • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • steroid hormone secretion • regulation of lipid transport • organic hydroxy compound transport • lipid localization • positive regulation of lipid localization • endocrine process • regulation of lipid localization • response to xenobiotic stimulus • neuropeptide signaling pathway • behavior • locomotory behavior • response to peptide • response to estrogen • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • positive regulation of apoptotic process • regulation of developmental process • regulation of hair cycle • catagen • hair cycle phase • positive regulation of hair follicle maturation • positive regulation of developmental process • regulation of timing of catagen • positive regulation of timing of catagen • hair follicle maturation • regulation of hair follicle maturation • regulation of multicellular organismal development • biological phase • developmental maturation • positive regulation of hair follicle development • anatomical structure maturation • regulation of hair follicle development • adult behavior • behavioral response to ethanol • response to ethanol • drinking behavior • feeding behavior • negative regulation of lymphocyte proliferation • regulation of leukocyte activation • regulation of cell activation • lymphocyte activation • negative regulation of lymphocyte activation • leukocyte proliferation • leukocyte activation • negative regulation of mononuclear cell proliferation • negative regulation of leukocyte proliferation • lymphocyte proliferation • negative regulation of cellular process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • negative regulation of cell population proliferation • negative regulation of cell activation • regulation of cell population proliferation • mononuclear cell proliferation • regulation of mononuclear cell proliferation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • regulation of lymphocyte activation • regulation of hormone metabolic process • steroid metabolic process • regulation of steroid metabolic process • regulation of lipid metabolic process • primary metabolic process • hormone metabolic process • regulation of primary metabolic process • glucocorticoid metabolic process • regulation of glucocorticoid metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • nervous system development • response to immobilization stress • response to insulin • parental behavior • reproductive process • multicellular organismal reproductive process • reproductive behavior • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • intracellular vesicle • cytoplasmic vesicle • secretory granule • secretory vesicle • neuronal cell body • neuropeptide binding • peptide binding • peptide hormone binding • hormone binding • learning or memory • phosphatidylinositol metabolic process • glycerophospholipid metabolic process • phospholipid metabolic process • organophosphate metabolic process • phosphate-containing compound metabolic process • glycerolipid metabolic process • phosphorus metabolic process • polyol metabolic process • alcohol metabolic process • small molecule metabolic process • inositol phosphate metabolic process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • cellular component organization • generation of neurons • neurogenesis • neuron differentiation • cell differentiation • neuron development • cellular component organization or biogenesis • galanin-activated signaling pathway
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43603
Sequence	>7WQ4_nogp_Chain_R H P E A V I V P L L F A L I F L V G T V G N T L V L A V L L R G G Q A V S T T N L F I L N L G V A D L C F I L C C V P F Q A T I Y T L D G W V F G S L L C K A V H F L I F L T M H A S S F T L A A V S L D R Y L A I R Y P L H S R E L R T P R N A L A A I G L I W G L S L L F S G P Y L S Y Y R Q S Q L A N L T V C H P A W S A P R R R A M D I C T F V F S Y L L P V L V L G L T Y A R T L R Y L W R A V A G S G A R R A K R K V T R M I L I V A A L F C L C W M P H H A L I L C V W F G Q F P L T R A T Y A L R I L S H L V S Y A N S C V N P I V Y A L V S K H F R K G F R T I C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

Chain	L
Protein	Galanin
UniProt	P22466
Sequence	>7WQ4_nogp_Chain_L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WQ4	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7WQ4 (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-		2.6	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7XJK	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XJK (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-		3.3	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XJL	A	Peptide	Galanin	GAL₂	Homo sapiens	Spexin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.5	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XJL (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Spexin	-		3.5	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XBD	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.11	2022-07-13	doi.org/10.1371/journal.pbio.3001714
	7XBD (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-		3.11	2022-07-13	doi.org/10.1371/journal.pbio.3001714

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