psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:S6	L:L:W2	6.18	No	Yes	0	0	0
2	L:L:W2	R:R:L266	15.94	Yes	No	0	0	1
3	L:L:W2	R:R:T270	7.28	Yes	No	0	0	4
4	L:L:W2	R:R:Y271	21.22	Yes	Yes	0	0	3
5	L:L:W2	R:R:R274	6	Yes	Yes	0	0	3
6	L:L:L4	R:R:L169	4.15	No	No	0	0	2
7	L:L:N5	R:R:I85	4.25	No	No	0	0	5
8	L:L:N5	R:R:H176	5.1	No	No	0	0	4
9	L:L:S6	R:R:Y86	3.82	No	Yes	0	0	5
10	L:L:G8	L:L:V16	5.52	No	No	0	0	0
11	L:L:Y9	R:R:Q82	7.89	Yes	No	1	0	6
12	L:L:Y9	R:R:I85	14.51	Yes	No	0	0	5
13	L:L:Y9	R:R:H102	7.62	Yes	No	1	0	4
14	L:L:Y9	R:R:Y164	8.94	Yes	Yes	1	0	5
15	L:L:L10	L:L:L11	4.15	Yes	No	0	0	0
16	L:L:L10	R:R:V259	4.47	Yes	No	1	0	4
17	L:L:L10	R:R:F264	3.65	Yes	Yes	1	0	5
18	L:L:L10	R:R:R274	15.79	Yes	Yes	1	0	3
19	L:L:G12	L:L:P13	4.06	No	No	0	0	0
20	L:L:V16	R:R:L169	4.47	No	No	0	0	2
21	R:R:E24	R:R:R268	4.65	No	No	0	4	1
22	R:R:P29	R:R:V28	5.3	No	No	0	5	6
23	R:R:A83	R:R:F32	5.55	No	No	0	6	7
24	R:R:F32	R:R:Y282	7.22	No	Yes	0	7	7
25	R:R:I35	R:R:Y282	3.63	No	Yes	0	7	7
26	R:R:F36	R:R:T40	7.78	No	No	0	7	6
27	R:R:F36	R:R:P80	5.78	No	No	0	7	8
28	R:R:G39	R:R:V38	3.68	No	No	0	8	6
29	R:R:C286	R:R:G39	3.92	No	No	0	7	8
30	R:R:L72	R:R:N43	13.73	Yes	No	2	8	9
31	R:R:N43	R:R:P289	14.66	No	No	2	9	9
32	R:R:F303	R:R:L45	3.65	Yes	No	0	7	6
33	R:R:P289	R:R:V46	3.53	No	No	0	9	9
34	R:R:L294	R:R:V46	4.47	No	No	0	6	9
35	R:R:F299	R:R:V46	7.87	Yes	No	0	8	9
36	R:R:L47	R:R:V69	8.94	No	No	0	7	6
37	R:R:F299	R:R:V49	13.11	Yes	Yes	0	8	7
38	R:R:F303	R:R:V49	3.93	Yes	Yes	0	7	7
39	R:R:L50	R:R:N61	4.12	Yes	No	0	6	7
40	R:R:L50	R:R:L65	4.15	Yes	No	0	6	6
41	R:R:F299	R:R:L50	7.31	Yes	Yes	0	8	6
42	R:R:N61	R:R:Q55	5.28	No	No	0	7	6
43	R:R:N61	R:R:S58	7.45	No	No	0	7	8
44	R:R:D122	R:R:T59	7.23	No	No	5	8	6
45	R:R:R137	R:R:T59	9.06	Yes	No	5	6	6
46	R:R:A142	R:R:T59	5.03	No	No	0	7	6
47	R:R:A142	R:R:L62	4.73	No	No	0	7	5
48	R:R:L143	R:R:L62	4.15	No	No	0	3	5
49	R:R:A118	R:R:F63	4.16	No	No	0	7	7
50	R:R:D122	R:R:F63	8.36	No	No	0	8	7
51	R:R:N66	R:R:T115	10.24	Yes	No	3	9	8
52	R:R:I146	R:R:N66	12.74	No	Yes	0	7	9
53	R:R:I149	R:R:N66	4.25	No	Yes	3	7	9
54	R:R:N66	R:R:W150	6.78	Yes	Yes	3	9	9
55	R:R:D71	R:R:L67	4.07	Yes	Yes	2	9	9
56	R:R:L116	R:R:L67	5.54	No	Yes	2	8	9
57	R:R:L67	R:R:N288	6.87	Yes	No	0	9	9
58	R:R:L67	R:R:Y292	4.69	Yes	Yes	2	9	9
59	R:R:G68	R:R:L72	5.13	No	Yes	0	8	8
60	R:R:A70	R:R:W150	3.89	No	Yes	0	8	9
61	R:R:D71	R:R:L72	9.5	Yes	Yes	2	9	8
62	R:R:D71	R:R:S112	11.78	Yes	No	0	9	9
63	R:R:D71	R:R:S285	4.42	Yes	Yes	2	9	9
64	R:R:L72	R:R:S285	6.01	Yes	Yes	2	8	9
65	R:R:L72	R:R:N288	6.87	Yes	No	0	8	9
66	R:R:L72	R:R:P289	6.57	Yes	No	2	8	9
67	R:R:F74	R:R:T108	6.49	No	No	0	7	8
68	R:R:I75	R:R:T108	4.56	No	No	0	7	8
69	R:R:I75	R:R:S285	4.64	No	Yes	0	7	9
70	R:R:L76	R:R:S285	4.5	No	Yes	0	4	9
71	R:R:C78	R:R:I105	4.91	No	No	0	7	5
72	R:R:P80	R:R:V79	3.53	No	No	0	8	7
73	R:R:V79	R:R:Y282	20.19	No	Yes	0	7	7
74	R:R:F81	R:R:F93	5.36	No	Yes	0	6	6
75	R:R:F81	R:R:V101	11.8	No	No	0	6	5
76	R:R:H278	R:R:Q82	8.65	Yes	No	1	5	6
77	R:R:Q82	R:R:Y282	9.02	No	Yes	1	6	7
78	R:R:L88	R:R:T84	8.84	No	No	0	4	3
79	R:R:F93	R:R:T84	9.08	Yes	No	0	6	3
80	R:R:Y271	R:R:Y86	8.94	Yes	Yes	0	3	5
81	R:R:R274	R:R:Y86	14.4	Yes	Yes	1	3	5
82	R:R:H278	R:R:Y86	9.8	Yes	Yes	1	5	5
83	R:R:L88	R:R:T87	5.9	No	No	0	4	4
84	R:R:F93	R:R:W91	19.04	Yes	Yes	0	6	8
85	R:R:C98	R:R:W91	5.22	No	Yes	6	9	8
86	R:R:C175	R:R:W91	15.67	No	Yes	6	9	8
87	R:R:F93	R:R:V92	7.87	Yes	No	0	6	3
88	R:R:F93	R:R:L97	6.09	Yes	No	0	6	5
89	R:R:G94	R:R:Q166	4.93	No	No	0	7	5
90	R:R:Q166	R:R:S95	10.11	No	No	0	5	3
91	R:R:C175	R:R:C98	7.28	No	No	6	9	9
92	R:R:K99	R:R:Q165	4.07	No	No	0	6	4
93	R:R:H102	R:R:Y164	31.58	No	Yes	1	4	5
94	R:R:F103	R:R:S157	3.96	No	No	0	6	7
95	R:R:F103	R:R:L161	6.09	No	No	0	6	5
96	R:R:F106	R:R:I105	5.02	No	No	0	4	5
97	R:R:F106	R:R:M109	6.22	No	No	0	4	7
98	R:R:F106	R:R:Y160	30.95	No	Yes	0	4	4
99	R:R:L107	R:R:W150	6.83	No	Yes	3	4	9
100	R:R:L107	R:R:S153	4.5	No	No	3	4	8
101	R:R:L107	R:R:S157	6.01	No	No	0	4	7
102	R:R:M109	R:R:S195	4.6	No	No	0	7	6
103	R:R:M109	R:R:W249	12.8	No	Yes	0	7	9
104	R:R:F156	R:R:H110	7.92	Yes	No	0	4	6
105	R:R:H110	R:R:T191	6.85	No	No	0	6	5
106	R:R:H110	R:R:S195	9.76	No	No	0	6	6
107	R:R:A111	R:R:W150	7.78	No	Yes	0	6	9
108	R:R:S113	R:R:S195	4.89	No	No	0	7	6
109	R:R:P199	R:R:S113	5.34	No	No	0	8	7
110	R:R:F245	R:R:S113	5.28	Yes	No	0	9	7
111	R:R:F114	R:R:I149	5.02	No	No	3	6	7
112	R:R:F114	R:R:L152	3.65	No	No	3	6	4
113	R:R:F114	R:R:F156	4.29	No	Yes	3	6	4
114	R:R:I149	R:R:T115	4.56	No	No	3	7	8
115	R:R:F245	R:R:L116	7.31	Yes	No	0	9	8
116	R:R:L116	R:R:Y292	7.03	No	Yes	2	8	9
117	R:R:R123	R:R:V119	5.23	Yes	No	2	9	9
118	R:R:V119	R:R:Y292	6.31	No	Yes	2	9	9
119	R:R:L203	R:R:S120	7.51	No	No	0	8	9
120	R:R:S120	R:R:T206	7.99	No	No	0	9	7
121	R:R:S120	R:R:Y207	15.26	No	Yes	0	9	9
122	R:R:L121	R:R:T206	5.9	No	No	0	6	7
123	R:R:D122	R:R:R137	13.1	No	Yes	5	8	6
124	R:R:R123	R:R:Y207	12.35	Yes	Yes	2	9	9
125	R:R:R123	R:R:V241	3.92	Yes	No	2	9	8
126	R:R:R123	R:R:Y292	4.12	Yes	Yes	2	9	9
127	R:R:R128	R:R:Y124	11.32	No	No	0	7	8
128	R:R:T210	R:R:Y124	6.24	No	No	0	8	8
129	R:R:L125	R:R:S133	6.01	No	No	5	5	6
130	R:R:L125	R:R:L136	4.15	No	No	0	5	3
131	R:R:L125	R:R:R137	4.86	No	Yes	5	5	6
132	R:R:A126	R:R:R137	6.91	No	Yes	0	8	6
133	R:R:R128	R:R:Y129	10.29	No	No	0	7	6
134	R:R:R128	R:R:Y213	20.58	No	No	0	7	5
135	R:R:S133	R:R:Y129	5.09	No	No	0	6	6
136	R:R:L131	R:R:R134	7.29	No	No	0	6	4
137	R:R:R137	R:R:S133	3.95	Yes	No	5	6	6
138	R:R:N141	R:R:T138	7.31	No	No	0	4	7
139	R:R:S153	R:R:W150	6.18	No	Yes	3	8	9
140	R:R:F156	R:R:L152	4.87	Yes	No	3	4	4
141	R:R:F156	R:R:F194	22.51	Yes	No	0	4	4
142	R:R:G158	R:R:P159	4.06	No	No	0	4	7
143	R:R:M187	R:R:P159	5.03	No	No	0	5	7
144	R:R:Y160	R:R:Y163	13.9	Yes	Yes	1	4	4
145	R:R:M187	R:R:Y160	13.17	No	Yes	1	5	4
146	R:R:T191	R:R:Y160	8.74	No	Yes	0	5	4
147	R:R:S162	R:R:W179	7.41	No	Yes	0	4	4
148	R:R:Y163	R:R:Y164	12.91	Yes	Yes	1	4	5
149	R:R:P177	R:R:Y163	6.95	Yes	Yes	1	4	4
150	R:R:W179	R:R:Y163	9.65	Yes	Yes	1	4	4
151	R:R:R184	R:R:Y163	13.38	Yes	Yes	1	4	4
152	R:R:M187	R:R:Y163	4.79	No	Yes	1	5	4
153	R:R:D188	R:R:Y163	5.75	No	Yes	0	5	4
154	R:R:P177	R:R:Y164	9.74	Yes	Yes	1	4	5
155	R:R:A178	R:R:Q165	6.06	No	No	0	4	4
156	R:R:Q166	R:R:T173	5.67	No	No	0	5	5
157	R:R:Q168	R:R:T173	8.5	No	No	0	3	5
158	R:R:L169	R:R:V174	4.47	No	Yes	0	2	4
159	R:R:H176	R:R:V174	11.07	No	Yes	0	4	4
160	R:R:H176	R:R:P177	4.58	No	Yes	0	4	4
161	R:R:P177	R:R:R184	11.53	Yes	Yes	1	4	4
162	R:R:R183	R:R:W179	12	No	Yes	0	2	4
163	R:R:R184	R:R:W179	4	Yes	Yes	1	4	4
164	R:R:P182	R:R:S180	3.56	No	No	0	1	4
165	R:R:R184	R:R:W260	13	Yes	No	0	4	4
166	R:R:R185	R:R:W260	14.99	No	No	0	3	4
167	R:R:F261	R:R:R185	8.55	No	No	0	4	3
168	R:R:D188	R:R:I256	4.2	No	No	0	5	6
169	R:R:D188	R:R:W260	15.63	No	No	0	5	4
170	R:R:F192	R:R:Y196	8.25	Yes	Yes	4	5	8
171	R:R:F192	R:R:L197	6.09	Yes	No	0	5	4
172	R:R:F192	R:R:H253	9.05	Yes	No	4	5	8
173	R:R:F192	R:R:L257	4.87	Yes	No	0	5	6
174	R:R:V200	R:R:Y196	7.57	No	Yes	0	6	8
175	R:R:M250	R:R:Y196	7.18	No	Yes	0	5	8
176	R:R:H253	R:R:Y196	4.36	No	Yes	4	8	8
177	R:R:F245	R:R:V200	5.24	Yes	No	0	9	6
178	R:R:L201	R:R:L205	5.54	No	No	0	3	4
179	R:R:F245	R:R:L203	8.53	Yes	No	0	9	8
180	R:R:I238	R:R:Y207	7.25	No	Yes	0	7	9
181	R:R:V241	R:R:Y207	3.79	No	Yes	2	8	9
182	R:R:L211	R:R:T235	5.9	No	No	0	4	6
183	R:R:I238	R:R:L211	7.14	No	No	0	7	4
184	R:R:K231	R:R:W215	4.64	No	No	0	7	4
185	R:R:T235	R:R:W215	7.28	No	No	0	6	4
186	R:R:V241	R:R:Y292	11.36	No	Yes	2	8	9
187	R:R:L244	R:R:V287	5.96	No	No	0	7	6
188	R:R:L244	R:R:V291	4.47	No	No	0	7	8
189	R:R:C248	R:R:N284	6.3	No	No	0	8	9
190	R:R:H252	R:R:W249	8.46	No	Yes	4	7	9
191	R:R:H253	R:R:W249	5.29	No	Yes	4	8	9
192	R:R:S281	R:R:W249	6.18	No	Yes	4	7	9
193	R:R:N284	R:R:W249	9.04	No	Yes	0	9	9
194	R:R:P251	R:R:V280	5.3	No	No	0	9	8
195	R:R:H252	R:R:I256	6.63	No	No	0	7	6
196	R:R:H252	R:R:S281	4.18	No	No	4	7	7
197	R:R:F264	R:R:L255	3.65	Yes	No	0	5	4
198	R:R:C258	R:R:F264	4.19	No	Yes	0	4	5
199	R:R:F264	R:R:V259	3.93	Yes	No	1	5	4
200	R:R:P265	R:R:Q263	4.74	No	No	0	3	4
201	R:R:F264	R:R:P265	4.33	Yes	No	0	5	3
202	R:R:F264	R:R:T270	7.78	Yes	No	0	5	4
203	R:R:T267	R:R:T270	4.71	No	No	0	3	4
204	R:R:I275	R:R:Y271	6.04	No	Yes	0	3	3
205	R:R:H278	R:R:R274	14.67	Yes	Yes	1	5	3
206	R:R:H278	R:R:S277	4.18	Yes	No	0	5	6
207	R:R:H278	R:R:Y282	5.44	Yes	Yes	1	5	7
208	R:R:N284	R:R:N288	6.81	No	No	0	9	9
209	R:R:A293	R:R:F299	9.71	No	Yes	0	7	8
210	R:R:G302	R:R:T305	3.64	No	No	0	5	3
211	R:R:F303	R:R:R304	10.69	Yes	No	0	7	4
212	R:R:C307	R:R:F303	5.59	No	Yes	0	6	7
213	R:R:I85	R:R:W91	3.52	No	Yes	0	5	8
214	R:R:P29	R:R:T87	3.5	No	No	0	5	4
215	R:R:P139	R:R:T138	3.5	No	No	0	2	7
216	R:R:G42	R:R:L45	3.42	No	No	0	7	6
217	L:L:N5	R:R:G90	3.39	No	No	0	0	5
218	R:R:A117	R:R:V202	3.39	No	No	0	7	6
219	R:R:A269	R:R:T267	3.36	No	No	0	2	3
220	R:R:M250	R:R:P251	3.35	No	No	0	5	9
221	R:R:C286	R:R:I35	3.27	No	No	0	7	7
222	R:R:S167	R:R:V174	3.23	No	Yes	0	1	4
223	R:R:R209	R:R:R212	3.2	No	No	0	4	4
224	R:R:C73	R:R:N43	3.15	No	No	0	7	9
225	R:R:I238	R:R:V234	3.07	No	No	0	7	7
226	R:R:I240	R:R:V291	3.07	No	No	0	6	8
227	R:R:I64	R:R:T60	3.04	No	No	0	8	7
228	R:R:I127	R:R:T210	3.04	No	No	0	8	8
229	R:R:M237	R:R:V295	3.04	No	No	0	8	6
230	R:R:G226	R:R:R229	3	No	No	0	3	4
231	R:R:L121	R:R:V202	2.98	No	No	0	6	6
232	R:R:L214	R:R:V234	2.98	No	No	0	7	7
233	R:R:L276	R:R:V280	2.98	No	No	0	6	8
234	R:R:L239	R:R:T235	2.95	No	No	0	5	6
235	L:L:G1	R:R:Y271	2.9	No	Yes	0	0	3
236	L:L:T3	R:R:D89	2.89	No	No	0	0	4
237	R:R:I64	R:R:L50	2.85	No	Yes	0	8	6
238	R:R:I127	R:R:L214	2.85	No	No	0	8	7
239	R:R:I275	R:R:L279	2.85	No	No	0	3	5
240	R:R:G94	R:R:W91	2.81	No	Yes	0	7	8
241	R:R:C190	R:R:F194	2.79	No	No	0	3	4
242	R:R:L279	R:R:L31	2.77	No	No	0	5	4
243	R:R:L51	R:R:L65	2.77	No	No	0	4	6
244	R:R:A145	R:R:F63	2.77	No	No	0	5	7
245	R:R:L148	R:R:L152	2.77	No	No	0	3	4
246	R:R:R183	R:R:S180	2.64	No	No	0	2	4
247	R:R:F299	R:R:S296	2.64	Yes	No	0	8	8
248	R:R:F192	R:R:V193	2.62	Yes	No	0	5	4
249	R:R:V291	R:R:Y292	2.52	No	Yes	0	8	9
250	R:R:K233	R:R:R236	2.48	No	No	0	7	6
251	R:R:H298	R:R:Q55	2.47	No	No	0	5	6
252	R:R:F103	R:R:L154	2.44	No	No	0	6	4
253	R:R:F156	R:R:L155	2.44	Yes	No	0	4	4
254	R:R:F194	R:R:L198	2.44	No	No	0	4	5
255	R:R:G53	R:R:G54	2.11	No	No	0	5	6
256	R:R:A181	R:R:P182	1.87	No	No	0	3	1
257	R:R:G226	R:R:S225	1.86	No	No	0	3	3
258	R:R:G42	R:R:V41	1.84	No	No	0	7	4
259	R:R:G302	R:R:V49	1.84	No	Yes	0	5	7
260	R:R:P23	R:R:V26	1.77	No	No	0	4	6
261	R:R:G147	R:R:I146	1.76	No	No	0	3	7
262	L:L:G12	L:L:L11	1.71	No	No	0	0	0
263	R:R:C246	R:R:V200	1.71	No	No	0	5	6
264	R:R:G204	R:R:L203	1.71	No	No	0	4	8
265	L:L:A7	L:L:V16	1.7	No	No	0	0	0
266	R:R:A70	R:R:V69	1.7	No	No	0	8	6
267	R:R:L62	R:R:P139	1.64	No	No	0	5	2
268	R:R:A254	R:R:M250	1.61	No	No	0	6	5
269	L:L:S6	L:L:T3	1.6	No	No	0	0	0
270	R:R:C78	R:R:L104	1.59	No	No	0	7	5
271	L:L:L4	R:R:A170	1.58	No	No	0	0	2
272	R:R:A243	R:R:L247	1.58	No	No	0	5	5
273	R:R:T40	R:R:T44	1.57	No	No	0	6	4
274	R:R:I27	R:R:V26	1.54	No	No	0	5	6
275	R:R:I27	R:R:V28	1.54	No	No	0	5	6
276	R:R:I306	R:R:V49	1.54	No	Yes	0	5	7
277	R:R:I189	R:R:V193	1.54	No	No	0	5	4
278	R:R:I290	R:R:V295	1.54	No	No	0	6	6
279	R:R:K99	R:R:S162	1.53	No	No	0	6	4
280	R:R:A272	R:R:E24	1.51	No	No	0	1	4
281	R:R:L34	R:R:V38	1.49	No	No	0	5	6
282	R:R:L172	R:R:V174	1.49	No	Yes	0	1	4
283	R:R:K233	R:R:K297	1.44	No	No	0	7	4
284	R:R:E24	R:R:V28	1.43	No	No	0	4	6
285	R:R:P130	R:R:Y129	1.39	No	No	0	8	6
286	R:R:A230	R:R:R229	1.38	No	No	0	5	4
287	R:R:A242	R:R:Y207	1.33	No	Yes	0	8	9
288	R:R:R140	R:R:T138	1.29	No	No	0	4	7
289	R:R:I240	R:R:R236	1.25	No	No	0	6	6
290	R:R:K233	R:R:R229	1.24	No	No	0	7	4
291	R:R:L51	R:R:R52	1.21	No	No	0	4	4
292	R:R:R209	R:R:Y124	1.03	No	No	0	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:W2	11.324	5	0	0
2	L:L:Y9	9.74	4	1	0
3	L:L:L10	7.015	4	1	0
4	R:R:V49	5.105	4	0	7
5	R:R:L50	4.6075	4	0	6
6	R:R:N66	8.5025	4	3	9
7	R:R:L67	5.2925	4	2	9
8	R:R:D71	7.4425	4	2	9
9	R:R:L72	7.96833	6	2	8
10	R:R:Y86	9.24	4	1	5
11	R:R:W91	9.252	5	6	8
12	R:R:F93	9.488	5	0	6
13	R:R:R123	6.405	4	2	9
14	R:R:R137	7.576	5	5	6
15	R:R:W150	6.292	5	3	9
16	R:R:F156	8.406	5	3	4
17	R:R:Y160	16.69	4	1	4
18	R:R:Y163	9.61857	7	1	4
19	R:R:Y164	15.7925	4	1	5
20	R:R:V174	5.065	4	0	4
21	R:R:P177	8.2	4	1	4
22	R:R:W179	8.265	4	1	4
23	R:R:R184	10.4775	4	1	4
24	R:R:F192	6.176	5	4	5
25	R:R:Y196	6.84	4	4	8
26	R:R:Y207	7.996	5	2	9
27	R:R:F245	6.59	4	0	9
28	R:R:W249	8.354	5	4	9
29	R:R:F264	4.58833	6	1	5
30	R:R:Y271	9.775	4	0	3
31	R:R:R274	12.715	4	1	3
32	R:R:H278	8.548	5	1	5
33	R:R:Y282	9.1	5	1	7
34	R:R:S285	4.8925	4	2	9
35	R:R:Y292	6.005	6	2	9
36	R:R:F299	8.128	5	0	8
37	R:R:F303	5.965	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L169	R:R:V174	12.0575	4.47	No	Yes	0	2	4
2	R:R:H176	R:R:V174	17.9694	11.07	No	Yes	0	4	4
3	L:L:Y9	R:R:I85	43.8522	14.51	Yes	No	0	0	5
4	L:L:Y9	R:R:Q82	68.5447	7.89	Yes	No	1	0	6
5	R:R:H278	R:R:Q82	44.9456	8.65	Yes	No	1	5	6
6	R:R:H278	R:R:Y86	15.5667	9.8	Yes	Yes	1	5	5
7	R:R:H176	R:R:P177	20.4029	4.58	No	Yes	0	4	4
8	L:L:Y9	R:R:Y164	100	8.94	Yes	Yes	1	0	5
9	L:L:L10	R:R:R274	17.652	15.79	Yes	Yes	1	0	3
10	R:R:I85	R:R:W91	42.0006	3.52	No	Yes	0	5	8
11	R:R:F93	R:R:W91	28.4927	19.04	Yes	Yes	0	6	8
12	R:R:F93	R:R:T84	19.7637	9.08	Yes	No	0	6	3
13	R:R:L88	R:R:T84	17.9914	8.84	No	No	0	4	3
14	R:R:L88	R:R:T87	16.2104	5.9	No	No	0	4	4
15	R:R:P29	R:R:T87	14.4205	3.5	No	No	0	5	4
16	R:R:P29	R:R:V28	12.6218	5.3	No	No	0	5	6
17	R:R:Y163	R:R:Y164	99.3299	12.91	Yes	Yes	1	4	5
18	R:R:Y160	R:R:Y163	96.9316	13.9	Yes	Yes	1	4	4
19	R:R:F106	R:R:Y160	61.5703	30.95	No	Yes	0	4	4
20	R:R:F106	R:R:M109	62.2316	6.22	No	No	0	4	7
21	R:R:M109	R:R:W249	39.642	12.8	No	Yes	0	7	9
22	R:R:N284	R:R:W249	61.0237	9.04	No	Yes	0	9	9
23	R:R:N284	R:R:N288	60.1331	6.81	No	No	0	9	9
24	R:R:L72	R:R:N288	54.3711	6.87	Yes	No	0	8	9
25	R:R:D188	R:R:Y163	33.254	5.75	No	Yes	0	5	4
26	R:R:D188	R:R:I256	34.3517	4.2	No	No	0	5	6
27	R:R:H252	R:R:I256	34.6383	6.63	No	No	0	7	6
28	R:R:H252	R:R:W249	34.603	8.46	No	Yes	4	7	9
29	R:R:L72	R:R:P289	54.4152	6.57	Yes	No	2	8	9
30	R:R:P289	R:R:V46	52.6385	3.53	No	No	0	9	9
31	R:R:F299	R:R:V46	48.662	7.87	Yes	No	0	8	9
32	R:R:F299	R:R:V49	21.8534	13.11	Yes	Yes	0	8	7
33	R:R:F303	R:R:V49	13.2214	3.93	Yes	Yes	0	7	7
34	R:R:T191	R:R:Y160	40.3165	8.74	No	Yes	0	5	4
35	R:R:H110	R:R:T191	40.3562	6.85	No	No	0	6	5
36	R:R:F156	R:R:H110	26.3413	7.92	Yes	No	0	4	6
37	R:R:F114	R:R:F156	19.0319	4.29	No	Yes	3	6	4
38	R:R:F114	R:R:I149	18.1237	5.02	No	No	3	6	7
39	R:R:I149	R:R:N66	15.9194	4.25	No	Yes	3	7	9
40	R:R:N66	R:R:W150	12.7011	6.78	Yes	Yes	3	9	9
41	R:R:F299	R:R:L50	21.774	7.31	Yes	Yes	0	8	6
42	R:R:M109	R:R:S195	36.4987	4.6	No	No	0	7	6
43	R:R:S113	R:R:S195	65.4984	4.89	No	No	0	7	6
44	R:R:F245	R:R:S113	64.5461	5.28	Yes	No	0	9	7
45	R:R:F245	R:R:L203	48.7413	8.53	Yes	No	0	9	8
46	R:R:L203	R:R:S120	45.9728	7.51	No	No	0	8	9
47	R:R:S120	R:R:Y207	42.8427	15.26	No	Yes	0	9	9
48	R:R:I238	R:R:Y207	64.9165	7.25	No	Yes	0	7	9
49	R:R:I238	R:R:V234	54.1771	3.07	No	No	0	7	7
50	R:R:L214	R:R:V234	52.4754	2.98	No	No	0	7	7
51	R:R:I127	R:R:L214	50.7869	2.85	No	No	0	8	7
52	R:R:I127	R:R:T210	49.0632	3.04	No	No	0	8	8
53	R:R:T210	R:R:Y124	47.1983	6.24	No	No	0	8	8
54	R:R:R128	R:R:Y124	41.5377	11.32	No	No	0	7	8
55	R:R:R128	R:R:Y129	37.7111	10.29	No	No	0	7	6
56	R:R:S133	R:R:Y129	33.858	5.09	No	No	0	6	6
57	R:R:R137	R:R:S133	27.8887	3.95	Yes	No	5	6	6
58	R:R:H110	R:R:S195	43.4422	9.76	No	No	0	6	6
59	R:R:R137	R:R:T59	16.0825	9.06	Yes	No	5	6	6
60	R:R:A142	R:R:T59	14.3764	5.03	No	No	0	7	6
61	R:R:A142	R:R:L62	12.3485	4.73	No	No	0	7	5
62	R:R:L67	R:R:N288	34.5545	6.87	Yes	No	0	9	9
63	R:R:D71	R:R:L67	20.9672	4.07	Yes	Yes	2	9	9
64	R:R:D71	R:R:L72	16.7438	9.5	Yes	Yes	2	9	8
65	R:R:F245	R:R:L116	21.8446	7.31	Yes	No	0	9	8
66	R:R:L116	R:R:Y292	16.1222	7.03	No	Yes	2	8	9
67	R:R:L67	R:R:Y292	45.8052	4.69	Yes	Yes	2	9	9
68	R:R:W179	R:R:Y163	15.7872	9.65	Yes	Yes	1	4	4
69	R:R:R123	R:R:Y292	18.397	4.12	Yes	Yes	2	9	9
70	R:R:V241	R:R:Y292	18.5249	11.36	No	Yes	2	8	9
71	R:R:H253	R:R:W249	16.5851	5.29	No	Yes	4	8	9
72	R:R:I238	R:R:L211	10.1398	7.14	No	No	0	7	4
73	R:R:V291	R:R:Y292	29.0085	2.52	No	Yes	0	8	9
74	R:R:I240	R:R:V291	21.0686	3.07	No	No	0	6	8
75	R:R:I240	R:R:R236	18.6219	1.25	No	No	0	6	6
76	R:R:K233	R:R:R236	15.9503	2.48	No	No	0	7	6
77	R:R:K233	R:R:R229	10.8407	1.24	No	No	0	7	4
78	R:R:H278	R:R:R274	27.6639	14.67	Yes	Yes	1	5	3
79	R:R:Q82	R:R:Y282	22.2281	9.02	No	Yes	1	6	7
80	R:R:P177	R:R:Y163	18.6042	6.95	Yes	Yes	1	4	4
81	R:R:R123	R:R:Y207	16.5895	12.35	Yes	Yes	2	9	9
82	R:R:V241	R:R:Y207	16.4705	3.79	No	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:W2	R:R:L266	15.94	0	Yes	No	0	1	0	1
L:L:W2	R:R:T270	7.28	0	Yes	No	0	4	0	1
L:L:W2	R:R:Y271	21.22	0	Yes	Yes	0	3	0	1
L:L:W2	R:R:R274	6	0	Yes	Yes	0	3	0	1
L:L:L4	R:R:L169	4.15	0	No	No	0	2	0	1
L:L:N5	R:R:I85	4.25	0	No	No	0	5	0	1
L:L:N5	R:R:H176	5.1	0	No	No	0	4	0	1
L:L:S6	R:R:Y86	3.82	0	No	Yes	0	5	0	1
L:L:Y9	R:R:Q82	7.89	1	Yes	No	0	6	0	1
L:L:Y9	R:R:I85	14.51	1	Yes	No	0	5	0	1
L:L:Y9	R:R:H102	7.62	1	Yes	No	0	4	0	1
L:L:Y9	R:R:Y164	8.94	1	Yes	Yes	0	5	0	1
L:L:L10	R:R:V259	4.47	1	Yes	No	0	4	0	1
L:L:L10	R:R:F264	3.65	1	Yes	Yes	0	5	0	1
L:L:L10	R:R:R274	15.79	1	Yes	Yes	0	3	0	1
L:L:V16	R:R:L169	4.47	0	No	No	0	2	0	1
R:R:H278	R:R:Q82	8.65	1	Yes	No	5	6	2	1
R:R:Q82	R:R:Y282	9.02	1	No	Yes	6	7	1	2
R:R:Y271	R:R:Y86	8.94	0	Yes	Yes	3	5	1	1
R:R:R274	R:R:Y86	14.4	1	Yes	Yes	3	5	1	1
R:R:H278	R:R:Y86	9.8	1	Yes	Yes	5	5	2	1
R:R:H102	R:R:Y164	31.58	1	No	Yes	4	5	1	1
R:R:Y163	R:R:Y164	12.91	1	Yes	Yes	4	5	2	1
R:R:P177	R:R:Y163	6.95	1	Yes	Yes	4	4	2	2
R:R:P177	R:R:Y164	9.74	1	Yes	Yes	4	5	2	1
R:R:L169	R:R:V174	4.47	0	No	Yes	2	4	1	2
R:R:H176	R:R:V174	11.07	0	No	Yes	4	4	1	2
R:R:H176	R:R:P177	4.58	0	No	Yes	4	4	1	2
R:R:F264	R:R:L255	3.65	1	Yes	No	5	4	1	2
R:R:C258	R:R:F264	4.19	0	No	Yes	4	5	2	1
R:R:F264	R:R:V259	3.93	1	Yes	No	5	4	1	1
R:R:F264	R:R:P265	4.33	1	Yes	No	5	3	1	2
R:R:F264	R:R:T270	7.78	1	Yes	No	5	4	1	1
R:R:T267	R:R:T270	4.71	0	No	No	3	4	2	1
R:R:I275	R:R:Y271	6.04	0	No	Yes	3	3	2	1
R:R:H278	R:R:R274	14.67	1	Yes	Yes	5	3	2	1
R:R:H278	R:R:Y282	5.44	1	Yes	Yes	5	7	2	2
R:R:I85	R:R:W91	3.52	0	No	Yes	5	8	1	2
L:L:N5	R:R:G90	3.39	0	No	No	0	5	0	1
L:L:G1	R:R:Y271	2.9	0	No	Yes	0	3	0	1
L:L:T3	R:R:D89	2.89	0	No	No	0	4	0	1
L:L:L4	R:R:A170	1.58	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XJK_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	265
Number of Links	292
Number of Hubs	37
Number of Links mediated by Hubs	138
Number of Communities	6
Number of Nodes involved in Communities	52
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	83
Number Of Links MetaPath	82
Number of Shortest Paths	54473
Length Of Smallest Path	3
Average Path Length	15.5733
Length of Longest Path	39
Minimum Path Strength	1.31
Average Path Strength	7.65556
Maximum Path Strength	22.425
Minimum Path Correlation	0.7
Average Path Correlation	0.925722
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	45.3305
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.1615
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • molecular function activator activity • signaling receptor binding • neuropeptide activity • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • neuropeptide hormone activity • signaling receptor regulator activity • receptor ligand activity • galanin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • galanin receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • type 2 galanin receptor binding • type 1 galanin receptor binding • type 3 galanin receptor binding • positive regulation of cell communication • multicellular organismal process • regulation of localization • system process • regulation of cellular process • positive regulation of steroid hormone secretion • regulation of system process • cell communication • regulation of glucocorticoid secretion • localization • positive regulation of cortisol secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • regulation of biological quality
Gene Ontology	Biological Process	• positive regulation of cell communication • multicellular organismal process • regulation of localization • system process • regulation of cellular process • positive regulation of steroid hormone secretion • regulation of system process • cell communication • regulation of glucocorticoid secretion • localization • positive regulation of cortisol secretion • positive regulation of glucocorticoid secretion • regulation of steroid hormone secretion • regulation of biological quality • regulation of biological process • cortisol secretion • positive regulation of corticosteroid hormone secretion • regulation of hormone levels • lipid transport • regulation of corticosteroid hormone secretion • establishment of localization • regulation of secretion • endocrine hormone secretion • positive regulation of lipid transport • lipid export from cell • regulation of cortisol secretion • positive regulation of multicellular organismal process • glucocorticoid secretion • regulation of endocrine process • corticosteroid hormone secretion • regulation of hormone secretion • transport • signaling • steroid hormone secretion • positive regulation of biological process • regulation of lipid transport • organic hydroxy compound transport • positive regulation of secretion by cell • hormone secretion • secretion by cell • regulation of secretion by cell • positive regulation of hormone secretion • positive regulation of secretion • signal release • regulation of multicellular organismal process • positive regulation of cellular process • regulation of signaling • secretion • regulation of transport • biological regulation • lipid localization • export from cell • cell-cell signaling • positive regulation of lipid localization • endocrine process • positive regulation of transport • regulation of lipid localization • macromolecule localization • hormone transport • regulation of cell communication • cellular process • positive regulation of signaling • response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • G protein-coupled receptor signaling pathway • signal transduction • neuropeptide signaling pathway • response to hormone • response to endogenous stimulus • response to estrogen • positive regulation of programmed cell death • regulation of apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • apoptotic process • programmed cell death • regulation of developmental process • epidermis development • molting cycle process • regulation of hair cycle • catagen • hair cycle phase • positive regulation of hair follicle maturation • positive regulation of developmental process • multicellular organism development • regulation of timing of catagen • skin epidermis development • hair follicle development • anatomical structure development • positive regulation of timing of catagen • hair follicle maturation • developmental process • regulation of hair follicle maturation • epithelium development • regulation of multicellular organismal development • biological phase • hair cycle • animal organ development • developmental maturation • tissue development • positive regulation of hair follicle development • skin development • anatomical structure maturation • molting cycle • regulation of hair follicle development • hair cycle process • behavior • feeding behavior • positive regulation of cation transmembrane transport • monoatomic ion transmembrane transport • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • positive regulation of large conductance calcium-activated potassium channel activity • monoatomic cation transmembrane transport • positive regulation of molecular function • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • regulation of monoatomic ion transport • positive regulation of cation channel activity • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • positive regulation of transporter activity • positive regulation of ion transmembrane transporter activity • regulation of monoatomic cation transmembrane transport • negative regulation of lymphocyte proliferation • regulation of leukocyte activation • negative regulation of biological process • regulation of cell activation • lymphocyte activation • negative regulation of lymphocyte activation • leukocyte proliferation • leukocyte activation • negative regulation of mononuclear cell proliferation • negative regulation of leukocyte proliferation • lymphocyte proliferation • negative regulation of cellular process • regulation of immune system process • regulation of lymphocyte proliferation • regulation of leukocyte proliferation • negative regulation of cell population proliferation • cell population proliferation • cell activation • negative regulation of cell activation • negative regulation of immune system process • regulation of cell population proliferation • mononuclear cell proliferation • immune system process • regulation of mononuclear cell proliferation • negative regulation of multicellular organismal process • negative regulation of leukocyte activation • regulation of lymphocyte activation • regulation of hormone metabolic process • steroid metabolic process • regulation of steroid metabolic process • regulation of lipid metabolic process • primary metabolic process • hormone metabolic process • regulation of primary metabolic process • glucocorticoid metabolic process • regulation of glucocorticoid metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • nervous system development • system development • response to immobilization stress • response to stress • response to peptide hormone • response to insulin • response to oxygen-containing compound • response to nitrogen compound • parental behavior • reproductive process • multicellular organismal reproductive process • reproductive behavior • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • establishment of protein localization • nitrogen compound transport • protein localization to extracellular region • peptide secretion • amide transport • intracellular protein localization • establishment of protein localization to extracellular region • protein secretion • peptide transport • protein transport • peptide hormone secretion • insulin secretion • membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • extracellular region
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • extracellular region • somatodendritic compartment • cell body • neuronal cell body • extracellular space • galanin receptor activity • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • neuropeptide receptor activity • binding • neuropeptide binding • peptide binding • amide binding • peptide hormone binding • hormone binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • neuropeptide signaling pathway • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • polyol metabolic process • organophosphate metabolic process • phosphate-containing compound metabolic process • metabolic process • alcohol metabolic process • small molecule metabolic process • inositol phosphate metabolic process • phosphorus metabolic process • behavior • multicellular organismal process • feeding behavior • galanin-activated signaling pathway • regulation of localization • positive regulation of cation transmembrane transport • transport • monoatomic ion transmembrane transport • positive regulation of biological process • regulation of transmembrane transporter activity • regulation of monoatomic ion transmembrane transport • positive regulation of large conductance calcium-activated potassium channel activity • monoatomic cation transmembrane transport • localization • positive regulation of molecular function • positive regulation of monoatomic ion transport • positive regulation of transmembrane transport • monoatomic ion transport • positive regulation of monoatomic ion transmembrane transport • monoatomic cation transport • positive regulation of cellular process • regulation of transport • regulation of monoatomic ion transport • positive regulation of cation channel activity • establishment of localization • transmembrane transport • regulation of molecular function • regulation of transmembrane transport • positive regulation of transport • positive regulation of transporter activity • positive regulation of ion transmembrane transporter activity • regulation of monoatomic cation transmembrane transport • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell surface receptor signaling pathway • phospholipase C-activating G protein-coupled receptor signaling pathway • system process • learning or memory • nervous system process • cognition • muscle contraction • muscle system process • phosphatidylinositol metabolic process • glycerophospholipid metabolic process • primary metabolic process • phospholipid metabolic process • glycerolipid metabolic process • lipid metabolic process • positive regulation of DNA-templated transcription • RNA metabolic process • positive regulation of macromolecule biosynthetic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • positive regulation of metabolic process • DNA-templated transcription • regulation of RNA metabolic process • transcription by RNA polymerase II • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • regulation of transcription by RNA polymerase II • regulation of macromolecule metabolic process • positive regulation of transcription by RNA polymerase II • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • positive regulation of RNA metabolic process • regulation of gene expression • biosynthetic process • positive regulation of RNA biosynthetic process • regulation of macromolecule biosynthetic process • macromolecule metabolic process • regulation of DNA-templated transcription • regulation of metabolic process • developmental process • plasma membrane bounded cell projection organization • cellular developmental process • cell projection organization • cell development • neuron projection development • nervous system development • cellular component organization • generation of neurons • neurogenesis • multicellular organism development • neuron differentiation • cell differentiation • neuron development • anatomical structure development • cellular component organization or biogenesis • system development • cell projection • cilium • plasma membrane bounded cell projection • membrane • cell periphery • plasma membrane • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43603
Sequence	>7XJK_nogp_Chain_R P E A V I V P L L F A L I F L V G T V G N T L V L A V L L R G G Q A V S T T N L F I L N L G V A D L C F I L C C V P F Q A T I Y T L D G W V F G S L L C K A V H F L I F L T M H A S S F T L A A V S L D R Y L A I R Y P L H S R E L R T P R N A L A A I G L I W G L S L L F S G P Y L S Y Y Q Q S Q L A N L T V C H P A W S A P R R R A M D I C T F V F S Y L L P V L V L G L T Y A R T L R Y L W R G S G A R R A K R K V T R M I L I V A A L F C L C W M P H H A L I L C V W F G Q F P L T R A T Y A L R I L S H L V S Y A N S C V N P I V Y A L V S K H F R K G F R T I C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7WQ4	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.6	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7WQ4 (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-		2.6	2022-04-20	doi.org/10.1038/s41467-022-29072-3
	7XJK	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.3	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XJK (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-		3.3	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XJL	A	Peptide	Galanin	GAL₂	Homo sapiens	Spexin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.5	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XJL (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Spexin	-		3.5	2022-06-29	doi.org/10.1073/pnas.2121465119
	7XBD	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-	chim(NtGi2L-Gs-CtGq)/β1/γ2	3.11	2022-07-13	doi.org/10.1371/journal.pbio.3001714
	7XBD (No Gprot)	A	Peptide	Galanin	GAL₂	Homo sapiens	Galanin	-		3.11	2022-07-13	doi.org/10.1371/journal.pbio.3001714

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7XJK_nogp.zip

You can click to copy the link of this page to easily come back here later

or use this QR code to link and share this page.

You can also read or download a guide explaining the meaning of all files and numerical data.