psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:K19	R:R:V21	4.55	No	No	0	3	5
2	R:R:F25	R:R:V29	5.24	No	No	0	5	7
3	R:R:L26	R:R:W299	11.39	No	Yes	0	6	6
4	R:R:M32	R:R:T28	4.52	No	No	0	5	5
5	R:R:I30	R:R:M74	5.83	No	Yes	0	6	7
6	R:R:I34	R:R:L67	4.28	No	No	0	7	7
7	R:R:I34	R:R:S70	4.64	No	No	0	7	7
8	R:R:G36	R:R:P309	4.06	No	Yes	0	8	9
9	R:R:D66	R:R:N37	6.73	Yes	No	0	9	9
10	R:R:L67	R:R:N37	5.49	No	No	0	7	9
11	R:R:N37	R:R:P309	6.52	No	Yes	0	9	9
12	R:R:L38	R:R:L67	4.15	No	No	0	4	7
13	R:R:F64	R:R:M41	6.22	No	No	0	6	8
14	R:R:V44	R:R:V60	4.81	No	No	0	7	6
15	R:R:I326	R:R:W46	4.7	No	No	0	7	6
16	R:R:D47	R:R:Q49	3.92	Yes	No	0	6	7
17	R:R:D47	R:R:L50	9.5	Yes	No	0	6	8
18	R:R:A322	R:R:D47	4.63	No	Yes	0	7	6
19	R:R:L50	R:R:N56	8.24	No	No	0	8	9
20	R:R:I53	R:R:N56	7.08	No	No	0	5	9
21	R:R:K54	R:R:Y57	8.36	No	No	0	6	4
22	R:R:K54	R:R:P135	5.02	No	No	0	6	3
23	R:R:D117	R:R:T55	5.78	No	No	6	8	8
24	R:R:T55	R:R:Y129	6.24	No	Yes	6	8	7
25	R:R:F319	R:R:N56	4.83	Yes	No	0	8	9
26	R:R:F58	R:R:I114	3.77	Yes	Yes	0	8	9
27	R:R:D117	R:R:F58	4.78	No	Yes	0	8	8
28	R:R:F58	R:R:I138	5.02	Yes	No	0	8	7
29	R:R:F58	R:R:M141	7.46	Yes	No	0	8	5
30	R:R:F319	R:R:I59	7.54	Yes	No	0	8	8
31	R:R:H110	R:R:S61	11.16	Yes	No	2	8	9
32	R:R:S61	R:R:W146	6.18	No	No	2	9	9
33	R:R:D66	R:R:L62	5.43	Yes	Yes	2	9	9
34	R:R:H110	R:R:L62	3.86	Yes	Yes	2	8	9
35	R:R:L111	R:R:L62	5.54	Yes	Yes	2	8	9
36	R:R:I114	R:R:L62	4.28	Yes	Yes	2	9	9
37	R:R:L62	R:R:N308	9.61	Yes	Yes	2	9	9
38	R:R:F64	R:R:L68	9.74	No	No	0	6	7
39	R:R:A65	R:R:W146	3.89	No	No	0	8	9
40	R:R:D66	R:R:S107	4.42	Yes	No	0	9	9
41	R:R:D66	R:R:S305	10.31	Yes	No	0	9	9
42	R:R:D66	R:R:N308	8.08	Yes	Yes	2	9	9
43	R:R:L103	R:R:L68	6.92	No	No	0	7	7
44	R:R:L103	R:R:V69	4.47	No	No	0	7	8
45	R:R:S305	R:R:V69	8.08	No	No	0	9	8
46	R:R:L72	R:R:V71	5.96	No	No	0	5	5
47	R:R:D100	R:R:V73	7.3	Yes	No	1	7	7
48	R:R:V73	R:R:Y302	3.79	No	Yes	1	7	7
49	R:R:M74	R:R:W299	6.98	Yes	Yes	1	7	6
50	R:R:M74	R:R:Y302	5.99	Yes	Yes	1	7	7
51	R:R:F76	R:R:F92	6.43	No	No	0	6	6
52	R:R:G77	R:R:R96	4.5	No	No	0	6	5
53	R:R:I79	R:R:Q83	4.12	No	No	0	5	4
54	R:R:E80	R:R:W86	7.63	No	Yes	0	4	7
55	R:R:L81	R:R:T295	5.9	No	No	0	4	3
56	R:R:L81	R:R:W299	7.97	No	Yes	0	4	6
57	R:R:I85	R:R:S181	6.19	No	No	0	5	1
58	R:R:W86	R:R:Y88	5.79	Yes	No	5	7	6
59	R:R:F92	R:R:W86	7.02	No	Yes	5	6	7
60	R:R:C93	R:R:W86	3.92	No	Yes	5	9	7
61	R:R:R96	R:R:W86	5	No	Yes	0	5	7
62	R:R:C184	R:R:W86	11.75	No	Yes	5	9	7
63	R:R:I87	R:R:Y88	6.04	No	No	0	3	6
64	R:R:F92	R:R:Y88	12.38	No	No	5	6	6
65	R:R:E90	R:R:K174	6.75	No	Yes	0	3	3
66	R:R:C184	R:R:C93	7.28	No	No	5	9	9
67	R:R:R96	R:R:Y302	5.14	No	Yes	0	5	7
68	R:R:F186	R:R:T97	9.08	Yes	No	0	4	4
69	R:R:F154	R:R:S98	15.85	Yes	No	0	4	6
70	R:R:D100	R:R:T104	4.34	Yes	No	1	7	7
71	R:R:D100	R:R:Y302	10.34	Yes	Yes	1	7	7
72	L:L:?1	R:R:D100	9.23	Yes	Yes	1	0	7
73	L:L:?1	R:R:V101	13.94	Yes	No	0	0	5
74	R:R:L102	R:R:S153	7.51	Yes	No	3	6	7
75	R:R:F154	R:R:L102	8.53	Yes	Yes	3	4	6
76	R:R:T104	R:R:W272	10.92	No	Yes	0	7	8
77	L:L:?1	R:R:T104	17.55	Yes	No	1	0	7
78	R:R:F109	R:R:T105	6.49	No	Yes	3	5	6
79	R:R:P149	R:R:T105	6.99	No	Yes	3	8	6
80	R:R:I152	R:R:T105	6.08	No	Yes	0	5	6
81	R:R:A200	R:R:T105	5.03	No	Yes	0	5	6
82	R:R:I108	R:R:W272	8.22	No	Yes	0	7	8
83	R:R:F109	R:R:I148	8.79	No	No	0	5	4
84	R:R:F109	R:R:P149	4.33	No	No	3	5	8
85	R:R:C145	R:R:H110	10.32	No	Yes	0	7	8
86	R:R:H110	R:R:W146	11.64	Yes	No	2	8	9
87	R:R:L111	R:R:N304	4.12	Yes	Yes	2	8	9
88	R:R:L111	R:R:N308	10.98	Yes	Yes	2	8	9
89	R:R:L111	R:R:Y312	7.03	Yes	Yes	2	8	9
90	R:R:C112	R:R:P204	3.77	Yes	No	0	8	8
91	R:R:C112	R:R:L207	4.76	Yes	No	0	8	6
92	R:R:C112	R:R:M208	4.86	Yes	Yes	0	8	8
93	R:R:I114	R:R:R118	3.76	Yes	No	2	9	9
94	R:R:I114	R:R:Y312	4.84	Yes	Yes	2	9	9
95	R:R:M208	R:R:S115	6.13	Yes	No	4	8	9
96	R:R:S115	R:R:Y212	6.36	No	Yes	4	9	9
97	R:R:D117	R:R:Y129	10.34	No	Yes	6	8	7
98	R:R:R118	R:R:Y312	9.26	No	Yes	2	9	9
99	R:R:C123	R:R:Y119	5.38	No	Yes	0	6	8
100	R:R:C124	R:R:Y119	6.72	No	Yes	0	7	8
101	R:R:R214	R:R:Y119	10.29	No	Yes	0	5	8
102	R:R:C124	R:R:Y120	8.06	No	Yes	0	7	4
103	R:R:Q125	R:R:Y120	10.15	No	Yes	0	6	4
104	R:R:K132	R:R:Y120	7.17	No	Yes	0	5	4
105	R:R:R137	R:R:Y120	4.12	No	Yes	0	6	4
106	R:R:A121	R:R:Y129	9.34	No	Yes	0	8	7
107	R:R:I122	R:R:I215	8.83	No	No	0	9	9
108	R:R:K132	R:R:V128	4.55	No	No	0	5	4
109	R:R:M133	R:R:Y129	8.38	No	Yes	0	7	7
110	R:R:M133	R:R:R137	3.72	No	No	0	7	6
111	R:R:P135	R:R:T134	5.25	No	No	0	3	8
112	R:R:F151	R:R:T150	5.19	No	No	0	4	4
113	R:R:F154	R:R:S153	6.61	Yes	No	3	4	7
114	R:R:F154	R:R:M158	4.98	Yes	No	0	4	4
115	R:R:L155	R:R:P156	8.21	No	No	0	7	5
116	R:R:L155	R:R:W161	4.56	No	No	0	7	5
117	R:R:P156	R:R:Y192	4.17	No	Yes	0	5	7
118	R:R:Q159	R:R:W161	9.86	No	No	0	5	5
119	R:R:N162	R:R:N163	12.26	No	No	0	5	5
120	R:R:N162	R:R:Y192	8.14	No	Yes	0	5	7
121	R:R:I170	R:R:N163	7.08	No	No	0	4	5
122	R:R:I166	R:R:N189	4.25	No	Yes	0	2	4
123	R:R:D168	R:R:L169	6.79	No	No	0	1	1
124	R:R:L169	R:R:M187	4.24	No	Yes	1	1	3
125	R:R:L169	R:R:Y287	4.69	No	Yes	1	1	3
126	R:R:I170	R:R:M187	7.29	No	Yes	0	4	3
127	R:R:M187	R:R:R173	8.69	Yes	No	0	3	3
128	R:R:F175	R:R:K174	3.72	No	Yes	0	1	3
129	R:R:F175	R:R:T182	7.78	No	No	0	1	4
130	R:R:N176	R:R:N178	4.09	No	No	0	5	3
131	R:R:V185	R:R:Y183	3.79	No	No	0	3	4
132	R:R:F186	R:R:V188	5.24	Yes	Yes	1	4	4
133	R:R:F186	R:R:Y192	5.16	Yes	Yes	1	4	7
134	L:L:?1	R:R:F186	6.21	Yes	Yes	1	0	4
135	R:R:M187	R:R:Y287	8.38	Yes	Yes	1	3	3
136	R:R:V188	R:R:Y192	5.05	Yes	Yes	1	4	7
137	R:R:N279	R:R:V188	5.91	Yes	Yes	1	5	4
138	L:L:?1	R:R:V188	3.8	Yes	Yes	1	0	4
139	R:R:N189	R:R:P191	13.03	Yes	No	0	4	3
140	R:R:N189	R:R:Y192	4.65	Yes	Yes	0	4	7
141	R:R:F284	R:R:K190	7.44	No	No	0	4	4
142	R:R:C196	R:R:Y192	10.75	No	Yes	0	5	7
143	R:R:F276	R:R:S197	5.28	Yes	No	0	7	6
144	R:R:N279	R:R:S197	5.96	Yes	No	0	5	6
145	R:R:I280	R:R:S197	6.19	No	No	0	5	6
146	L:L:?1	R:R:A200	4.02	Yes	No	0	0	5
147	R:R:F201	R:R:Y202	8.25	Yes	No	0	8	5
148	R:R:F201	R:R:F205	8.57	Yes	Yes	4	8	7
149	R:R:F201	R:R:F268	6.43	Yes	Yes	4	8	9
150	R:R:A273	R:R:F201	4.16	No	Yes	0	6	8
151	R:R:F201	R:R:F276	19.29	Yes	Yes	0	8	7
152	R:R:I280	R:R:Y202	7.25	No	No	0	5	5
153	R:R:F205	R:R:V209	7.87	Yes	No	0	7	5
154	R:R:F205	R:R:F268	5.36	Yes	Yes	4	7	9
155	R:R:L206	R:R:L210	5.54	No	No	0	4	4
156	R:R:M208	R:R:Y212	4.79	Yes	Yes	4	8	9
157	R:R:F268	R:R:M208	3.73	Yes	Yes	4	9	8
158	R:R:L261	R:R:Y212	4.69	No	Yes	0	8	9
159	R:R:M265	R:R:Y212	4.79	No	Yes	0	8	9
160	R:R:V217	R:R:Y213	7.57	No	No	0	3	3
161	R:R:K220	R:R:Y216	9.55	No	Yes	0	6	6
162	R:R:E254	R:R:K220	8.1	No	No	0	7	6
163	R:R:E221	R:R:Q225	11.47	No	No	0	4	4
164	R:R:H224	R:R:M228	17.07	No	No	0	4	4
165	R:R:Q227	R:R:R231	9.35	No	No	0	4	4
166	R:R:M228	R:R:R231	3.72	No	No	0	4	4
167	R:R:I263	R:R:K259	4.36	No	No	0	7	7
168	R:R:C267	R:R:L311	4.76	No	No	0	5	8
169	R:R:F268	R:R:W272	6.01	Yes	Yes	0	9	8
170	R:R:C271	R:R:N304	9.45	No	Yes	0	8	9
171	R:R:F276	R:R:W272	5.01	Yes	Yes	0	7	8
172	R:R:G301	R:R:W272	8.44	No	Yes	0	7	8
173	R:R:N304	R:R:W272	14.69	Yes	Yes	0	9	8
174	R:R:F297	R:R:P274	8.67	Yes	No	0	6	9
175	R:R:F275	R:R:W294	9.02	No	Yes	0	6	4
176	R:R:F275	R:R:L298	7.31	No	No	0	6	5
177	L:L:?1	R:R:F275	6.21	Yes	No	0	0	6
178	L:L:?1	R:R:F276	8.29	Yes	Yes	0	0	7
179	R:R:T278	R:R:V289	4.76	No	Yes	1	4	4
180	R:R:T278	R:R:W294	12.13	No	Yes	1	4	4
181	R:R:F297	R:R:T278	9.08	Yes	No	0	6	4
182	R:R:N279	R:R:W294	5.65	Yes	Yes	1	5	4
183	L:L:?1	R:R:N279	10.51	Yes	Yes	1	0	5
184	R:R:D282	R:R:Y287	6.9	Yes	Yes	1	3	3
185	R:R:D282	R:R:V289	8.76	Yes	Yes	1	3	4
186	R:R:D282	R:R:W294	12.28	Yes	Yes	1	3	4
187	R:R:P283	R:R:Y287	9.74	No	Yes	0	4	3
188	R:R:I285	R:R:T288	4.56	No	No	0	4	3
189	R:R:V289	R:R:W294	8.58	Yes	Yes	1	4	4
190	R:R:F297	R:R:V293	6.55	Yes	No	0	6	4
191	R:R:L298	R:R:Y302	14.07	No	Yes	0	5	7
192	R:R:W299	R:R:Y302	11.58	Yes	Yes	1	6	7
193	R:R:I303	R:R:L307	4.28	Yes	No	0	5	6
194	R:R:N304	R:R:N308	12.26	Yes	Yes	2	9	9
195	R:R:A313	R:R:F319	6.93	No	Yes	0	7	8
196	R:R:A313	R:R:F323	4.16	No	No	0	7	7
197	R:R:F314	R:R:R320	4.28	No	No	0	5	8
198	R:R:F319	R:R:N316	6.04	Yes	No	0	8	8
199	R:R:I325	R:R:R321	3.76	No	No	0	4	5
200	R:R:E221	R:R:H224	3.69	No	No	0	4	4
201	R:R:F154	R:R:L99	3.65	Yes	No	0	4	5
202	R:R:C113	R:R:C145	3.64	No	No	0	7	7
203	R:R:I157	R:R:Y192	3.63	No	Yes	0	5	7
204	R:R:I264	R:R:Y212	3.63	No	Yes	0	8	9
205	R:R:D47	R:R:R321	3.57	Yes	No	0	6	5
206	R:R:G144	R:R:I148	3.53	No	No	0	4	4
207	R:R:P290	R:R:V289	3.53	No	Yes	0	4	4
208	R:R:P290	R:R:V293	3.53	No	No	0	4	4
209	R:R:L261	R:R:Y216	3.52	No	Yes	0	8	6
210	R:R:A33	R:R:S70	3.42	No	No	0	8	7
211	R:R:A63	R:R:V40	3.39	No	No	0	9	9
212	R:R:A193	R:R:V188	3.39	No	Yes	0	5	4
213	R:R:I203	R:R:P204	3.39	No	No	0	5	8
214	R:R:C123	R:R:T218	3.38	No	No	0	6	6
215	R:R:K190	R:R:P283	3.35	No	No	0	4	4
216	R:R:L102	R:R:P149	3.28	Yes	No	3	6	8
217	R:R:C123	R:R:I122	3.27	No	No	0	6	9
218	R:R:S98	R:R:V95	3.23	No	No	0	6	5
219	R:R:A63	R:R:M41	3.22	No	No	0	9	8
220	R:R:T24	R:R:V21	3.17	No	No	0	5	5
221	R:R:C112	R:R:L116	3.17	Yes	No	0	8	6
222	R:R:T150	R:R:V147	3.17	No	No	0	4	4
223	R:R:A78	R:R:L26	3.15	No	No	0	6	6
224	R:R:I203	R:R:V198	3.07	No	No	0	5	5
225	R:R:I53	R:R:T55	3.04	No	No	0	5	8
226	R:R:A223	R:R:E254	3.02	No	No	0	5	7
227	R:R:L23	R:R:S27	3	No	No	0	6	4
228	R:R:L142	R:R:S61	3	No	No	0	7	9
229	R:R:L23	R:R:V82	2.98	No	No	0	6	5
230	R:R:L50	R:R:V44	2.98	No	No	0	8	7
231	R:R:N316	R:R:S318	2.98	No	No	0	8	6
232	R:R:L102	R:R:T150	2.95	Yes	No	0	6	4
233	R:R:A106	R:R:H110	2.93	No	Yes	0	8	8
234	R:R:I138	R:R:K54	2.91	No	No	0	7	6
235	R:R:I170	R:R:K174	2.91	No	Yes	0	4	3
236	R:R:I264	R:R:L315	2.85	No	No	0	8	7
237	R:R:D282	R:R:I285	2.8	Yes	No	0	3	4
238	R:R:C269	R:R:F205	2.79	No	Yes	0	6	7
239	R:R:A43	R:R:F323	2.77	No	No	0	8	7
240	R:R:I85	R:R:Q83	2.74	No	No	0	5	4
241	R:R:H222	R:R:T218	2.74	No	No	0	7	6
242	R:R:E171	R:R:K174	2.7	No	Yes	0	5	3
243	R:R:A211	R:R:Y119	2.67	No	Yes	0	7	8
244	R:R:A258	R:R:Y216	2.67	No	Yes	0	8	6
245	R:R:V277	R:R:Y202	2.52	No	No	0	6	5
246	R:R:F284	R:R:I194	2.51	No	No	0	4	5
247	R:R:I325	R:R:W46	2.35	No	No	0	4	6
248	R:R:L311	R:R:Y312	2.34	No	Yes	0	8	9
249	R:R:D84	R:R:Y183	2.3	No	No	0	4	4
250	R:R:G143	R:R:G144	2.11	No	No	0	3	4
251	R:R:G306	R:R:P309	2.03	No	Yes	0	6	9
252	R:R:A232	R:R:G233	1.95	No	No	0	4	5
253	R:R:A219	R:R:A257	1.79	No	No	0	8	8
254	R:R:G36	R:R:L35	1.71	No	No	0	8	5
255	R:R:G36	R:R:L39	1.71	No	No	0	8	7
256	R:R:G160	R:R:N162	1.7	No	No	0	7	5
257	R:R:M74	R:R:P75	1.68	Yes	No	0	7	8
258	R:R:C267	R:R:I263	1.64	No	No	0	5	7
259	R:R:C271	R:R:I303	1.64	No	Yes	0	8	5
260	R:R:G291	R:R:Q292	1.64	No	No	0	2	1
261	R:R:S179	R:R:S181	1.63	No	No	0	1	1
262	R:R:C93	R:R:L94	1.59	No	No	0	9	6
263	R:R:T195	R:R:V199	1.59	No	No	0	5	4
264	R:R:P126	R:R:Q125	1.58	No	No	0	8	6
265	R:R:P290	R:R:Q292	1.58	No	No	0	4	1
266	R:R:I303	R:R:V29	1.54	Yes	No	0	5	7
267	R:R:I148	R:R:V199	1.54	No	No	0	4	4
268	R:R:I152	R:R:V199	1.54	No	No	0	5	4
269	R:R:I285	R:R:V281	1.54	No	No	0	4	4
270	R:R:K174	R:R:V185	1.52	Yes	No	0	3	3
271	R:R:I264	R:R:T260	1.52	No	No	0	8	9
272	R:R:L39	R:R:V42	1.49	No	No	0	7	5
273	R:R:L68	R:R:V71	1.49	No	No	0	7	5
274	R:R:D84	R:R:S181	1.47	No	No	0	4	1
275	R:R:I85	R:R:I87	1.47	No	No	0	5	3
276	R:R:L136	R:R:T134	1.47	No	No	0	4	8
277	R:R:K256	R:R:K317	1.44	No	No	0	8	5
278	R:R:F310	R:R:P309	1.44	No	Yes	0	7	9
279	R:R:Q83	R:R:V82	1.43	No	No	0	4	5
280	R:R:I303	R:R:L300	1.43	Yes	No	0	5	7
281	R:R:I164	R:R:N189	1.42	No	Yes	0	5	4
282	R:R:G89	R:R:W86	1.41	No	Yes	0	8	7
283	R:R:A296	R:R:F297	1.39	No	Yes	0	5	6
284	R:R:E171	R:R:I167	1.37	No	No	0	5	1
285	R:R:E254	R:R:Q227	1.27	No	No	0	7	4
286	R:R:Y213	R:R:Y216	0.99	No	Yes	0	3	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D47	5.405	4	0	6
2	R:R:F58	5.2575	4	0	8
3	R:R:L62	5.744	5	2	9
4	R:R:D66	6.994	5	2	9
5	R:R:M74	5.12	4	1	7
6	R:R:W86	6.07429	7	5	7
7	R:R:D100	7.8025	4	1	7
8	R:R:L102	5.5675	4	3	6
9	R:R:T105	6.1475	4	3	6
10	R:R:H110	7.982	5	2	8
11	R:R:L111	6.9175	4	2	8
12	R:R:C112	4.14	4	0	8
13	R:R:I114	4.1625	4	2	9
14	R:R:Y119	6.265	4	0	8
15	R:R:Y120	7.375	4	0	4
16	R:R:Y129	8.575	4	6	7
17	R:R:F154	7.924	5	3	4
18	R:R:K174	3.52	5	0	3
19	R:R:F186	6.4225	4	1	4
20	R:R:M187	7.15	4	1	3
21	R:R:V188	4.678	5	1	4
22	R:R:N189	5.8375	4	0	4
23	R:R:Y192	5.93571	7	1	7
24	R:R:F201	9.34	5	4	8
25	R:R:F205	6.1475	4	4	7
26	R:R:M208	4.8775	4	4	8
27	R:R:Y212	4.852	5	4	9
28	R:R:Y216	4.1825	4	0	6
29	R:R:F268	5.3825	4	4	9
30	R:R:W272	8.88167	6	0	8
31	R:R:F276	9.4675	4	0	7
32	R:R:N279	7.0075	4	1	5
33	R:R:D282	7.685	4	1	3
34	R:R:Y287	7.4275	4	1	3
35	R:R:V289	6.4075	4	1	4
36	R:R:W294	9.532	5	1	4
37	R:R:F297	6.4225	4	0	6
38	R:R:W299	9.48	4	1	6
39	R:R:Y302	8.485	6	1	7
40	R:R:I303	2.2225	4	0	5
41	R:R:N304	10.13	4	2	9
42	R:R:N308	10.2325	4	2	9
43	R:R:P309	3.5125	4	0	9
44	R:R:Y312	5.8675	4	2	9
45	R:R:F319	6.335	4	0	8
46	L:L:?1	8.86222	9	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:N304	R:R:W272	100	14.69	Yes	Yes	0	9	8
2	R:R:T104	R:R:W272	51.8917	10.92	No	Yes	0	7	8
3	R:R:D100	R:R:T104	11.0529	4.34	Yes	No	1	7	7
4	R:R:D100	R:R:Y302	13.3247	10.34	Yes	Yes	1	7	7
5	R:R:N304	R:R:N308	41.9216	12.26	Yes	Yes	2	9	9
6	R:R:D66	R:R:N308	12.8788	8.08	Yes	Yes	2	9	9
7	R:R:L111	R:R:N304	56.5413	4.12	Yes	Yes	2	8	9
8	R:R:L111	R:R:L62	29.1404	5.54	Yes	Yes	2	8	9
9	R:R:I114	R:R:L62	51.2095	4.28	Yes	Yes	2	9	9
10	R:R:F58	R:R:I114	74.1221	3.77	Yes	Yes	0	8	9
11	R:R:D117	R:R:F58	61.9368	4.78	No	Yes	0	8	8
12	R:R:D117	R:R:T55	31.817	5.78	No	No	6	8	8
13	R:R:I53	R:R:T55	30.737	3.04	No	No	0	5	8
14	R:R:I53	R:R:N56	29.1447	7.08	No	No	0	5	9
15	R:R:L50	R:R:N56	16.3041	8.24	No	No	0	8	9
16	R:R:L62	R:R:N308	28.8658	9.61	Yes	Yes	2	9	9
17	R:R:L111	R:R:Y312	27.7533	7.03	Yes	Yes	2	8	9
18	R:R:I114	R:R:Y312	24.8843	4.84	Yes	Yes	2	9	9
19	R:R:D47	R:R:L50	11.4422	9.5	Yes	No	0	6	8
20	R:R:D117	R:R:Y129	28.5828	10.34	No	Yes	6	8	7
21	R:R:F319	R:R:N56	11.4422	4.83	Yes	No	0	8	9
22	R:R:I170	R:R:K174	13.4619	2.91	No	Yes	0	4	3
23	R:R:I170	R:R:N163	14.4881	7.08	No	No	0	4	5
24	R:R:N162	R:R:N163	16.0139	12.26	No	No	0	5	5
25	R:R:N162	R:R:Y192	19.1335	8.14	No	Yes	0	5	7
26	R:R:F186	R:R:Y192	17.9134	5.16	Yes	Yes	1	4	7
27	L:L:?1	R:R:F186	19.534	6.21	Yes	Yes	1	0	4
28	L:L:?1	R:R:T104	40.7213	17.55	Yes	No	1	0	7
29	R:R:V188	R:R:Y192	18.4612	5.05	Yes	Yes	1	4	7
30	L:L:?1	R:R:V188	19.4152	3.8	Yes	Yes	1	0	4
31	L:L:?1	R:R:F276	47.2194	8.29	Yes	Yes	0	0	7
32	R:R:F276	R:R:W272	50.8995	5.01	Yes	Yes	0	7	8
33	R:R:P149	R:R:T105	10.1032	6.99	No	Yes	3	8	6
34	R:R:A200	R:R:T105	17.3444	5.03	No	Yes	0	5	6
35	L:L:?1	R:R:A200	18.229	4.02	Yes	No	0	0	5
36	R:R:F268	R:R:M208	25.6415	3.73	Yes	Yes	4	9	8
37	R:R:F268	R:R:W272	22.4668	6.01	Yes	Yes	0	9	8
38	R:R:M208	R:R:Y212	18.2319	4.79	Yes	Yes	4	8	9
39	R:R:C124	R:R:Y119	13.0118	6.72	No	Yes	0	7	8
40	R:R:C124	R:R:Y120	14.6325	8.06	No	Yes	0	7	4
41	R:R:R137	R:R:Y120	22.6932	4.12	No	Yes	0	6	4
42	R:R:M133	R:R:R137	24.2983	3.72	No	No	0	7	6
43	R:R:M133	R:R:Y129	25.8991	8.38	No	Yes	0	7	7
44	R:R:D282	R:R:Y287	18.1356	6.9	Yes	Yes	1	3	3
45	R:R:D282	R:R:W294	25.4873	12.28	Yes	Yes	1	3	4
46	R:R:F275	R:R:W294	19.0118	9.02	No	Yes	0	6	4
47	L:L:?1	R:R:F275	19.4888	6.21	Yes	No	0	0	6
48	R:R:N279	R:R:W294	27.7052	5.65	Yes	Yes	1	5	4
49	L:L:?1	R:R:N279	18.849	10.51	Yes	Yes	1	0	5
50	R:R:F276	R:R:S197	10.2829	5.28	Yes	No	0	7	6
51	R:R:L261	R:R:Y212	13.5525	4.69	No	Yes	0	8	9
52	R:R:L261	R:R:Y216	12.6028	3.52	No	Yes	0	8	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D100	R:R:V73	7.3	1	Yes	No	7	7	1	2
R:R:V73	R:R:Y302	3.79	1	No	Yes	7	7	2	2
R:R:F186	R:R:T97	9.08	1	Yes	No	4	4	1	2
R:R:D100	R:R:T104	4.34	1	Yes	No	7	7	1	1
R:R:D100	R:R:Y302	10.34	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:D100	9.23	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V101	13.94	1	Yes	No	0	5	0	1
R:R:T104	R:R:W272	10.92	1	No	Yes	7	8	1	2
L:L:?1	R:R:T104	17.55	1	Yes	No	0	7	0	1
R:R:A200	R:R:T105	5.03	0	No	Yes	5	6	1	2
R:R:F186	R:R:V188	5.24	1	Yes	Yes	4	4	1	1
R:R:F186	R:R:Y192	5.16	1	Yes	Yes	4	7	1	2
L:L:?1	R:R:F186	6.21	1	Yes	Yes	0	4	0	1
R:R:V188	R:R:Y192	5.05	1	Yes	Yes	4	7	1	2
R:R:N279	R:R:V188	5.91	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:V188	3.8	1	Yes	Yes	0	4	0	1
R:R:F276	R:R:S197	5.28	0	Yes	No	7	6	1	2
R:R:N279	R:R:S197	5.96	1	Yes	No	5	6	1	2
L:L:?1	R:R:A200	4.02	1	Yes	No	0	5	0	1
R:R:F201	R:R:F276	19.29	4	Yes	Yes	8	7	2	1
R:R:F276	R:R:W272	5.01	0	Yes	Yes	7	8	1	2
R:R:F275	R:R:W294	9.02	0	No	Yes	6	4	1	2
R:R:F275	R:R:L298	7.31	0	No	No	6	5	1	2
L:L:?1	R:R:F275	6.21	1	Yes	No	0	6	0	1
L:L:?1	R:R:F276	8.29	1	Yes	Yes	0	7	0	1
R:R:N279	R:R:W294	5.65	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:N279	10.51	1	Yes	Yes	0	5	0	1
R:R:L298	R:R:Y302	14.07	0	No	Yes	5	7	2	2
R:R:A193	R:R:V188	3.39	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XT8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.72
Number of Linked Nodes	263
Number of Links	286
Number of Hubs	46
Number of Links mediated by Hubs	165
Number of Communities	6
Number of Nodes involved in Communities	49
Number of Links involved in Communities	65

Path Summary
Number Of Nodes in MetaPath	53
Number Of Links MetaPath	52
Number of Shortest Paths	100602
Length Of Smallest Path	3
Average Path Length	14.7422
Length of Longest Path	29
Minimum Path Strength	1.485
Average Path Strength	6.99816
Maximum Path Strength	15.745
Minimum Path Correlation	0.7
Average Path Correlation	0.94099
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	54.6003
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	60.2624
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • serotonin binding • amine binding • heterocyclic compound binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • electron transport chain • metabolic process • generation of precursor metabolites and energy • multicellular organismal process • maintenance of gastrointestinal epithelium • system process • digestion • multicellular organismal-level homeostasis • epithelial structure maintenance • homeostatic process • digestive system process • anatomical structure homeostasis • tissue homeostasis • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • regulation of body fluid levels • secretion by tissue • secretion • transport • mucus secretion • establishment of localization • body fluid secretion • localization • regulation of biological quality • large intestinal transit • intestinal motility • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • regulation of cellular component organization • cellular component organization • cellular component biogenesis • multicellular organism development • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • anatomical structure development • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • system development • developmental process • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • response to nutrient levels • regulation of appetite • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • dendrite • dendritic tree • glutamatergic synapse • endosome membrane • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • postsynapse • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • carbohydrate derivative binding • ribonucleotide binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • nervous system process • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SRO
Name	Serotonin
Synonyms	Serotonin
Identifier
Formula	C10 H12 N2 O
Molecular Weight	176.215
SMILES
PubChem	5202
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13639
Sequence	>7XT8_nogp_Chain_R K V V L L T F L S T V I L M A I L G N L L V M V A V C W D R Q L R K I K T N Y F I V S L A F A D L L V S V L V M P F G A I E L V Q D I W I Y G E V F C L V R T S L D V L L T T A S I F H L C C I S L D R Y Y A I C C Q P L V Y R N K M T P L R I A L M L G G C W V I P T F I S F L P I M Q G W N N I G I I D L I E K R K F N Q N S N S T Y C V F M V N K P Y A I T C S V V A F Y I P F L L M V L A Y Y R I Y V T A K E H A H Q I Q M L Q R A G A S S E T K A A K T L C I I M G C F C L C W A P F F V T N I V D P F I D Y T V P G Q V W T A F L W L G Y I N S G L N P F L Y A F L N K S F R R A F L I I L C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XT8	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-	Gs/β1/γ2	3.1	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XT8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-		3.1	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XT9	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XT9 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTA	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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