psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L23	R:R:V82	5.96	No	No	0	6	5
2	R:R:F25	R:R:V29	5.24	No	No	0	5	7
3	R:R:L26	R:R:W299	10.25	No	Yes	0	6	6
4	R:R:I30	R:R:M74	4.37	No	Yes	1	6	7
5	R:R:I30	R:R:W299	3.52	No	Yes	1	6	6
6	R:R:A33	R:R:S70	3.42	No	No	0	8	7
7	R:R:I34	R:R:S70	4.64	No	No	0	7	7
8	R:R:I34	R:R:V71	4.61	No	No	0	7	5
9	R:R:G36	R:R:L39	3.42	No	No	0	8	7
10	R:R:D66	R:R:N37	6.73	Yes	No	0	9	9
11	R:R:L67	R:R:N37	6.87	No	No	0	7	9
12	R:R:N37	R:R:P309	4.89	No	Yes	0	9	9
13	R:R:L38	R:R:L67	5.54	No	No	0	4	7
14	R:R:A63	R:R:V40	3.39	No	No	0	9	9
15	R:R:I326	R:R:V42	6.14	No	No	0	7	5
16	R:R:V44	R:R:V60	4.81	No	No	0	7	6
17	R:R:F319	R:R:V44	3.93	Yes	No	0	8	7
18	R:R:D47	R:R:Q49	5.22	Yes	Yes	3	6	7
19	R:R:D47	R:R:L50	13.57	Yes	Yes	3	6	8
20	R:R:D47	R:R:R321	13.1	Yes	No	3	6	5
21	R:R:A322	R:R:D47	4.63	No	Yes	0	7	6
22	R:R:Q49	R:R:R48	5.84	Yes	No	0	7	6
23	R:R:K52	R:R:Q49	5.42	No	Yes	0	8	7
24	R:R:Q49	R:R:R321	5.84	Yes	No	3	7	5
25	R:R:L50	R:R:N56	4.12	Yes	No	3	8	9
26	R:R:L50	R:R:S318	4.5	Yes	No	0	8	6
27	R:R:F319	R:R:L50	10.96	Yes	Yes	3	8	8
28	R:R:I53	R:R:N56	12.74	No	No	0	5	9
29	R:R:K54	R:R:M133	8.64	No	Yes	0	6	7
30	R:R:D117	R:R:T55	7.23	No	No	2	8	8
31	R:R:T55	R:R:Y129	4.99	No	Yes	2	8	7
32	R:R:F319	R:R:N56	9.67	Yes	No	3	8	9
33	R:R:I138	R:R:Y57	3.63	No	No	0	7	4
34	R:R:F58	R:R:I114	3.77	Yes	No	0	8	9
35	R:R:D117	R:R:F58	7.17	No	Yes	2	8	8
36	R:R:F58	R:R:I138	3.77	Yes	No	2	8	7
37	R:R:F58	R:R:M141	4.98	Yes	No	0	8	5
38	R:R:F58	R:R:L142	7.31	Yes	No	2	8	7
39	R:R:F319	R:R:I59	3.77	Yes	No	0	8	8
40	R:R:H110	R:R:S61	11.16	Yes	No	1	8	9
41	R:R:S61	R:R:W146	6.18	No	No	1	9	9
42	R:R:D66	R:R:L62	5.43	Yes	Yes	1	9	9
43	R:R:H110	R:R:L62	7.71	Yes	Yes	1	8	9
44	R:R:L111	R:R:L62	6.92	No	Yes	1	8	9
45	R:R:I114	R:R:L62	4.28	No	Yes	0	9	9
46	R:R:L62	R:R:N308	5.49	Yes	Yes	1	9	9
47	R:R:F64	R:R:L68	12.18	No	No	0	6	7
48	R:R:D66	R:R:S107	4.42	Yes	No	0	9	9
49	R:R:D66	R:R:S305	10.31	Yes	No	0	9	9
50	R:R:D66	R:R:N308	9.42	Yes	Yes	1	9	9
51	R:R:L103	R:R:L68	5.54	No	No	0	7	7
52	R:R:V69	R:R:V73	4.81	Yes	No	0	8	7
53	R:R:M74	R:R:V69	4.56	Yes	Yes	0	7	8
54	R:R:L103	R:R:V69	4.47	No	Yes	0	7	8
55	R:R:S305	R:R:V69	6.46	No	Yes	0	9	8
56	R:R:S305	R:R:S70	3.26	No	No	0	9	7
57	R:R:D100	R:R:V73	7.3	Yes	No	1	7	7
58	R:R:V73	R:R:Y302	5.05	No	Yes	1	7	7
59	R:R:M74	R:R:W299	8.14	Yes	Yes	1	7	6
60	R:R:M74	R:R:Y302	10.78	Yes	Yes	1	7	7
61	R:R:F76	R:R:W86	4.01	No	Yes	4	6	7
62	R:R:F76	R:R:F92	6.43	No	Yes	4	6	6
63	R:R:F76	R:R:R96	10.69	No	No	4	6	5
64	R:R:I79	R:R:Q83	8.23	No	No	0	5	4
65	R:R:L81	R:R:T295	4.42	No	No	0	4	3
66	R:R:W86	R:R:Y88	17.36	Yes	No	4	7	6
67	R:R:F92	R:R:W86	8.02	Yes	Yes	4	6	7
68	R:R:C93	R:R:W86	5.22	No	Yes	0	9	7
69	R:R:R96	R:R:W86	5	No	Yes	4	5	7
70	R:R:I87	R:R:Y88	12.09	No	No	0	3	6
71	R:R:F92	R:R:Y88	11.35	Yes	No	4	6	6
72	R:R:E90	R:R:K174	5.4	No	No	0	3	3
73	R:R:F92	R:R:V95	3.93	Yes	No	0	6	5
74	R:R:C184	R:R:C93	3.64	No	No	0	9	9
75	R:R:L94	R:R:M158	5.65	No	No	0	6	4
76	R:R:F186	R:R:T97	9.08	No	No	0	4	4
77	R:R:F154	R:R:S98	15.85	Yes	No	0	4	6
78	R:R:D100	R:R:T104	4.34	Yes	No	1	7	7
79	R:R:D100	R:R:Y302	11.49	Yes	Yes	1	7	7
80	L:L:?1	R:R:D100	6.92	Yes	Yes	1	0	7
81	R:R:S153	R:R:V101	3.23	No	No	0	7	5
82	R:R:I157	R:R:V101	4.61	No	No	0	5	5
83	L:L:?1	R:R:V101	12.67	Yes	No	0	0	5
84	R:R:L102	R:R:P149	3.28	Yes	No	0	6	8
85	R:R:L102	R:R:S153	7.51	Yes	No	5	6	7
86	R:R:F154	R:R:L102	8.53	Yes	Yes	5	4	6
87	R:R:T104	R:R:W272	7.28	No	Yes	1	7	8
88	L:L:?1	R:R:T104	8.77	Yes	No	1	0	7
89	R:R:F109	R:R:T105	3.89	No	Yes	0	5	6
90	R:R:P149	R:R:T105	6.99	No	Yes	0	8	6
91	R:R:I152	R:R:T105	7.6	No	Yes	0	5	6
92	R:R:A200	R:R:T105	3.36	No	Yes	0	5	6
93	R:R:I108	R:R:P204	3.39	No	No	0	7	8
94	R:R:F268	R:R:I108	6.28	Yes	No	1	9	7
95	R:R:I108	R:R:W272	7.05	No	Yes	1	7	8
96	R:R:F109	R:R:I148	8.79	No	No	0	5	4
97	R:R:C145	R:R:H110	14.74	No	Yes	0	7	8
98	R:R:H110	R:R:W146	10.58	Yes	No	1	8	9
99	R:R:L111	R:R:N308	8.24	No	Yes	1	8	9
100	R:R:L111	R:R:Y312	4.69	No	Yes	0	8	9
101	R:R:C112	R:R:S115	3.44	Yes	No	1	8	9
102	R:R:C112	R:R:P204	3.77	Yes	No	0	8	8
103	R:R:C112	R:R:L207	4.76	Yes	No	0	8	6
104	R:R:C112	R:R:M208	4.86	Yes	Yes	1	8	8
105	R:R:C113	R:R:C145	3.64	No	No	0	7	7
106	R:R:I114	R:R:R118	3.76	No	No	0	9	9
107	R:R:M208	R:R:S115	6.13	Yes	No	1	8	9
108	R:R:S115	R:R:Y212	5.09	No	Yes	1	9	9
109	R:R:D117	R:R:Y129	10.34	No	Yes	2	8	7
110	R:R:R118	R:R:Y312	6.17	No	Yes	0	9	9
111	R:R:C123	R:R:Y119	4.03	No	Yes	0	6	8
112	R:R:C124	R:R:Y119	5.38	No	Yes	0	7	8
113	R:R:R214	R:R:Y119	4.12	No	Yes	0	5	8
114	R:R:C124	R:R:Y120	4.03	No	Yes	0	7	4
115	R:R:Q125	R:R:Y120	6.76	No	Yes	0	6	4
116	R:R:Y120	R:R:Y129	3.97	Yes	Yes	2	4	7
117	R:R:K132	R:R:Y120	3.58	No	Yes	0	5	4
118	R:R:M133	R:R:Y120	3.59	Yes	Yes	2	7	4
119	R:R:A121	R:R:Y129	9.34	No	Yes	0	8	7
120	R:R:I122	R:R:I215	5.89	No	No	0	9	9
121	R:R:C123	R:R:T218	6.76	No	No	0	6	6
122	R:R:N131	R:R:V128	4.43	No	No	0	5	4
123	R:R:K132	R:R:V128	7.59	No	No	0	5	4
124	R:R:M133	R:R:Y129	10.78	Yes	Yes	2	7	7
125	R:R:P135	R:R:T134	3.5	No	No	0	3	8
126	R:R:I138	R:R:L142	4.28	No	No	2	7	7
127	R:R:I148	R:R:P149	3.39	No	No	0	4	8
128	R:R:C196	R:R:I152	4.91	No	No	0	5	5
129	R:R:F154	R:R:S153	6.61	Yes	No	5	4	7
130	R:R:F154	R:R:M158	3.73	Yes	No	0	4	4
131	R:R:L155	R:R:P156	4.93	No	No	0	7	5
132	R:R:L155	R:R:W161	4.56	No	No	0	7	5
133	R:R:P156	R:R:Y192	5.56	No	Yes	0	5	7
134	R:R:F186	R:R:I157	5.02	No	No	0	4	5
135	R:R:I157	R:R:Y192	6.04	No	Yes	0	5	7
136	R:R:Q159	R:R:W161	9.86	No	No	0	5	5
137	R:R:N162	R:R:N163	13.62	No	Yes	6	5	5
138	R:R:N162	R:R:Y192	4.65	No	Yes	0	5	7
139	R:R:I170	R:R:N163	7.08	No	Yes	0	4	5
140	R:R:I166	R:R:I170	5.89	No	No	0	2	4
141	R:R:I166	R:R:N189	4.25	No	Yes	0	2	4
142	R:R:I166	R:R:Y287	6.04	No	No	0	2	3
143	R:R:D168	R:R:L169	8.14	No	No	0	1	1
144	R:R:L169	R:R:M187	4.24	No	Yes	0	1	3
145	R:R:I170	R:R:M187	5.83	No	Yes	0	4	3
146	R:R:K172	R:R:N176	6.99	No	No	0	2	5
147	R:R:N176	R:R:R173	6.03	No	No	0	5	3
148	R:R:R173	R:R:Y183	8.23	No	No	0	3	4
149	R:R:F175	R:R:T182	3.89	No	No	0	1	4
150	R:R:N178	R:R:S179	4.47	No	No	0	3	1
151	R:R:V185	R:R:Y183	5.05	No	No	0	3	4
152	R:R:F186	R:R:V188	3.93	No	Yes	0	4	4
153	R:R:M187	R:R:Y287	8.38	Yes	No	0	3	3
154	R:R:V188	R:R:Y192	5.05	Yes	Yes	0	4	7
155	R:R:A193	R:R:V188	3.39	No	Yes	0	5	4
156	R:R:N279	R:R:V188	4.43	Yes	Yes	1	5	4
157	L:L:?1	R:R:V188	3.8	Yes	Yes	1	0	4
158	R:R:N189	R:R:P191	11.4	Yes	No	0	4	3
159	R:R:N189	R:R:Y192	3.49	Yes	Yes	0	4	7
160	R:R:K190	R:R:P191	3.35	No	No	0	4	3
161	R:R:I194	R:R:K190	4.36	No	No	0	5	4
162	R:R:F284	R:R:K190	13.65	No	No	0	4	4
163	R:R:C196	R:R:Y192	9.41	No	Yes	0	5	7
164	L:L:?1	R:R:C196	6.75	Yes	No	0	0	5
165	R:R:N279	R:R:S197	5.96	Yes	No	0	5	6
166	R:R:F201	R:R:Y202	6.19	Yes	No	0	8	5
167	R:R:F201	R:R:F205	3.22	Yes	No	1	8	7
168	R:R:F201	R:R:F268	4.29	Yes	Yes	1	8	9
169	R:R:F201	R:R:F276	21.43	Yes	No	0	8	7
170	R:R:I203	R:R:P204	3.39	No	No	0	5	8
171	R:R:F205	R:R:V209	7.87	No	No	0	7	5
172	R:R:F205	R:R:F268	3.22	No	Yes	1	7	9
173	R:R:M208	R:R:Y212	3.59	Yes	Yes	1	8	9
174	R:R:M208	R:R:M265	4.33	Yes	No	1	8	8
175	R:R:F268	R:R:M208	9.95	Yes	Yes	1	9	8
176	R:R:L261	R:R:Y212	8.21	No	Yes	0	8	9
177	R:R:M265	R:R:Y212	4.79	No	Yes	1	8	9
178	R:R:Y212	R:R:Y312	3.97	Yes	Yes	0	9	9
179	R:R:V217	R:R:Y213	8.83	No	No	0	3	3
180	R:R:A258	R:R:Y216	5.34	No	No	0	8	6
181	R:R:E221	R:R:Q225	5.1	No	No	0	4	4
182	R:R:H224	R:R:Q225	3.71	No	No	0	4	4
183	R:R:I263	R:R:K259	4.36	No	No	0	7	7
184	R:R:I264	R:R:Y312	4.84	No	Yes	0	8	9
185	R:R:C267	R:R:L307	4.76	No	No	0	5	6
186	R:R:C267	R:R:L311	6.35	No	No	0	5	8
187	R:R:F268	R:R:W272	5.01	Yes	Yes	1	9	8
188	R:R:C271	R:R:W272	3.92	No	Yes	1	8	8
189	R:R:C271	R:R:N304	9.45	No	No	1	8	9
190	R:R:F276	R:R:W272	4.01	No	Yes	0	7	8
191	R:R:G301	R:R:W272	8.44	No	Yes	0	7	8
192	R:R:N304	R:R:W272	14.69	No	Yes	1	9	8
193	R:R:F297	R:R:P274	7.22	Yes	No	0	6	9
194	R:R:F275	R:R:W294	5.01	No	Yes	0	6	4
195	R:R:F275	R:R:L298	4.87	No	No	0	6	5
196	L:L:?1	R:R:F275	13.47	Yes	No	0	0	6
197	L:L:?1	R:R:F276	9.32	Yes	No	0	0	7
198	R:R:D282	R:R:T278	5.78	Yes	Yes	1	3	4
199	R:R:T278	R:R:W294	4.85	Yes	Yes	1	4	4
200	R:R:F297	R:R:T278	9.08	Yes	Yes	0	6	4
201	R:R:N279	R:R:W294	4.52	Yes	Yes	1	5	4
202	L:L:?1	R:R:N279	12.85	Yes	Yes	1	0	5
203	R:R:I285	R:R:V281	6.14	No	No	0	4	4
204	R:R:D282	R:R:V289	8.76	Yes	No	1	3	4
205	R:R:D282	R:R:W294	11.17	Yes	Yes	1	3	4
206	R:R:P283	R:R:Y287	5.56	No	No	0	4	3
207	R:R:I285	R:R:T288	4.56	No	No	0	4	3
208	R:R:P290	R:R:V289	5.3	No	No	0	4	4
209	R:R:V289	R:R:W294	4.9	No	Yes	1	4	4
210	R:R:P290	R:R:V293	5.3	No	No	0	4	4
211	R:R:F297	R:R:V293	7.87	Yes	No	0	6	4
212	R:R:L298	R:R:Y302	15.24	No	Yes	0	5	7
213	R:R:W299	R:R:Y302	11.58	Yes	Yes	1	6	7
214	R:R:I303	R:R:L307	4.28	No	No	0	5	6
215	R:R:N304	R:R:N308	8.17	No	Yes	1	9	9
216	R:R:A313	R:R:F319	4.16	No	Yes	0	7	8
217	R:R:F314	R:R:F323	3.22	No	No	0	5	7
218	R:R:N316	R:R:S318	4.47	No	No	0	8	6
219	R:R:F319	R:R:N316	8.46	Yes	No	0	8	8
220	R:R:F319	R:R:F323	3.22	Yes	No	0	8	7
221	R:R:I325	R:R:R321	6.26	No	No	0	4	5
222	R:R:R130	R:R:Y129	3.09	No	Yes	0	4	7
223	R:R:I148	R:R:V147	3.07	No	No	0	4	4
224	R:R:I203	R:R:V198	3.07	No	No	0	5	5
225	R:R:K19	R:R:V21	3.04	No	No	0	3	5
226	R:R:M41	R:R:V60	3.04	No	No	0	8	6
227	R:R:K174	R:R:V185	3.04	No	No	0	3	3
228	R:R:L72	R:R:V71	2.98	No	No	0	5	5
229	R:R:L99	R:R:V95	2.98	No	No	0	5	5
230	R:R:L102	R:R:T150	2.95	Yes	No	0	6	4
231	R:R:D84	R:R:S181	2.94	No	No	0	4	1
232	R:R:I85	R:R:I87	2.94	No	No	0	5	3
233	R:R:A65	R:R:H110	2.93	No	Yes	0	8	8
234	R:R:A106	R:R:H110	2.93	No	Yes	0	8	8
235	R:R:D282	R:R:V281	2.92	Yes	No	0	3	4
236	R:R:Q83	R:R:V82	2.87	No	No	0	4	5
237	R:R:K256	R:R:K259	2.87	No	No	0	8	7
238	R:R:I215	R:R:L261	2.85	No	No	0	9	8
239	R:R:I264	R:R:L311	2.85	No	No	0	8	8
240	R:R:L140	R:R:M141	2.83	No	No	0	3	5
241	R:R:I164	R:R:N189	2.83	No	Yes	0	5	4
242	R:R:G89	R:R:W86	2.81	No	Yes	0	8	7
243	R:R:L116	R:R:L207	2.77	No	No	0	6	6
244	R:R:L206	R:R:L210	2.77	No	No	0	4	4
245	R:R:H222	R:R:T218	2.74	No	No	0	7	6
246	R:R:A211	R:R:Y119	2.67	No	Yes	0	7	8
247	R:R:F323	R:R:V40	2.62	No	No	0	7	9
248	R:R:F151	R:R:T150	2.59	No	No	0	4	4
249	R:R:M187	R:R:R173	2.48	Yes	No	0	3	3
250	R:R:K317	R:R:R320	2.48	No	No	0	5	8
251	R:R:F154	R:R:L99	2.44	Yes	No	0	4	5
252	R:R:T295	R:R:W299	2.43	No	Yes	0	3	6
253	R:R:I280	R:R:Y202	2.42	No	No	0	5	5
254	R:R:I325	R:R:W46	2.35	No	No	0	4	6
255	R:R:I326	R:R:W46	2.35	No	No	0	7	6
256	R:R:E80	R:R:R96	2.33	No	No	0	4	5
257	R:R:G143	R:R:G144	2.11	No	No	0	3	4
258	R:R:G306	R:R:P309	2.03	No	Yes	0	6	9
259	R:R:A273	R:R:P274	1.87	No	No	0	6	9
260	R:R:G144	R:R:V147	1.84	No	No	0	4	4
261	R:R:A273	R:R:C269	1.81	No	No	0	6	6
262	R:R:A322	R:R:A43	1.79	No	No	0	7	8
263	R:R:P309	R:R:V40	1.77	Yes	No	0	9	9
264	R:R:G36	R:R:L35	1.71	No	No	0	8	5
265	R:R:G77	R:R:L81	1.71	No	No	0	6	4
266	R:R:G160	R:R:N162	1.7	No	No	6	7	5
267	R:R:G160	R:R:N163	1.7	No	Yes	6	7	5
268	R:R:I30	R:R:P75	1.69	No	No	0	6	8
269	R:R:L300	R:R:P274	1.64	No	No	0	7	9
270	R:R:V91	R:R:V95	1.6	No	No	0	1	5
271	R:R:T24	R:R:V20	1.59	No	No	0	5	6
272	R:R:T195	R:R:V199	1.59	No	No	0	5	4
273	R:R:T278	R:R:V277	1.59	Yes	No	0	4	6
274	R:R:A78	R:R:L23	1.58	No	No	0	6	6
275	R:R:A78	R:R:L26	1.58	No	No	0	6	6
276	R:R:P126	R:R:Q125	1.58	No	No	0	8	6
277	R:R:I85	R:R:S181	1.55	No	No	0	5	1
278	R:R:I303	R:R:V29	1.54	No	No	0	5	7
279	R:R:I152	R:R:V199	1.54	No	No	0	5	4
280	R:R:K19	R:R:V20	1.52	No	No	0	3	6
281	R:R:I264	R:R:T260	1.52	No	No	0	8	9
282	R:R:L22	R:R:V21	1.49	No	No	0	5	5
283	R:R:L136	R:R:T134	1.47	No	No	0	4	8
284	R:R:L315	R:R:T260	1.47	No	No	0	7	9
285	R:R:F310	R:R:P309	1.44	No	Yes	0	7	9
286	R:R:I326	R:R:L39	1.43	No	No	0	7	7
287	R:R:I263	R:R:L311	1.43	No	No	0	7	8
288	R:R:I167	R:R:N163	1.42	No	Yes	0	1	5
289	R:R:G291	R:R:W294	1.41	No	Yes	0	2	4
290	R:R:K317	R:R:N316	1.4	No	No	0	5	8
291	R:R:A296	R:R:F297	1.39	No	Yes	0	5	6
292	R:R:L22	R:R:L26	1.38	No	No	0	5	6
293	R:R:E171	R:R:I167	1.37	No	No	0	5	1
294	R:R:N176	R:R:N178	1.36	No	No	0	5	3
295	R:R:R137	R:R:T134	1.29	No	No	0	6	8
296	R:R:M133	R:R:R137	1.24	Yes	No	0	7	6
297	R:R:F175	R:R:K174	1.24	No	No	0	1	3
298	R:R:L261	R:R:Y216	1.17	No	No	0	8	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:D47	9.13	4	3	6
2	R:R:Q49	5.58	4	3	7
3	R:R:L50	8.2875	4	3	8
4	R:R:F58	5.4	5	2	8
5	R:R:L62	5.966	5	1	9
6	R:R:D66	7.262	5	1	9
7	R:R:V69	5.075	4	0	8
8	R:R:M74	6.9625	4	1	7
9	R:R:W86	7.07	6	4	7
10	R:R:F92	7.4325	4	4	6
11	R:R:D100	7.5125	4	1	7
12	R:R:L102	5.5675	4	5	6
13	R:R:T105	5.46	4	0	6
14	R:R:H110	8.34167	6	1	8
15	R:R:C112	4.2075	4	1	8
16	R:R:Y119	4.05	4	0	8
17	R:R:Y120	4.386	5	2	4
18	R:R:Y129	7.085	6	2	7
19	R:R:M133	6.0625	4	2	7
20	R:R:F154	7.432	5	5	4
21	R:R:N163	5.955	4	6	5
22	R:R:M187	5.2325	4	0	3
23	R:R:V188	4.12	5	1	4
24	R:R:N189	5.4925	4	0	4
25	R:R:Y192	5.7	6	0	7
26	R:R:F201	8.7825	4	1	8
27	R:R:M208	5.772	5	1	8
28	R:R:Y212	5.13	5	1	9
29	R:R:F268	5.75	5	1	9
30	R:R:W272	7.2	7	1	8
31	R:R:T278	5.325	4	1	4
32	R:R:N279	6.94	4	1	5
33	R:R:D282	7.1575	4	1	3
34	R:R:W294	5.31	6	1	4
35	R:R:F297	6.39	4	0	6
36	R:R:W299	7.184	5	1	6
37	R:R:Y302	10.828	5	1	7
38	R:R:N308	7.83	4	1	9
39	R:R:P309	2.5325	4	0	9
40	R:R:Y312	4.9175	4	0	9
41	R:R:F319	6.31	7	3	8
42	L:L:?1	9.31875	8	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C267	R:R:L307	12.1373	4.76	No	No	0	5	6
2	R:R:C267	R:R:L311	15.1564	6.35	No	No	0	5	8
3	R:R:I264	R:R:L311	27.201	2.85	No	No	0	8	8
4	R:R:I264	R:R:Y312	36.0863	4.84	No	Yes	0	8	9
5	R:R:L111	R:R:Y312	22.3343	4.69	No	Yes	0	8	9
6	R:R:D66	R:R:L62	10.6289	5.43	Yes	Yes	1	9	9
7	R:R:D66	R:R:S305	32.4702	10.31	Yes	No	0	9	9
8	R:R:S305	R:R:V69	34.1799	6.46	No	Yes	0	9	8
9	R:R:L111	R:R:N308	19.1569	8.24	No	Yes	1	8	9
10	R:R:D66	R:R:N308	46.333	9.42	Yes	Yes	1	9	9
11	R:R:I326	R:R:W46	10.0726	2.35	No	No	0	7	6
12	R:R:I325	R:R:W46	12.074	2.35	No	No	0	4	6
13	R:R:I325	R:R:R321	14.0709	6.26	No	No	0	4	5
14	R:R:D47	R:R:R321	16.009	13.1	Yes	No	3	6	5
15	R:R:D47	R:R:L50	27.9224	13.57	Yes	Yes	3	6	8
16	R:R:F319	R:R:L50	31.6516	10.96	Yes	Yes	3	8	8
17	R:R:F319	R:R:F323	54.6733	3.22	Yes	No	0	8	7
18	R:R:F323	R:R:V40	58.3618	2.62	No	No	0	7	9
19	R:R:P309	R:R:V40	62.1317	1.77	Yes	No	0	9	9
20	R:R:N37	R:R:P309	67.7424	4.89	No	Yes	0	9	9
21	R:R:D66	R:R:N37	73.3124	6.73	Yes	No	0	9	9
22	R:R:D117	R:R:Y129	29.2092	10.34	No	Yes	2	8	7
23	R:R:D117	R:R:F58	31.8166	7.17	No	Yes	2	8	8
24	R:R:F58	R:R:I114	39.1596	3.77	Yes	No	0	8	9
25	R:R:I114	R:R:L62	38.7413	4.28	No	Yes	0	9	9
26	R:R:D100	R:R:Y302	10.3824	11.49	Yes	Yes	1	7	7
27	R:R:F92	R:R:V95	17.1714	3.93	Yes	No	0	6	5
28	R:R:L99	R:R:V95	19.3966	2.98	No	No	0	5	5
29	R:R:F154	R:R:L99	20.5025	2.44	Yes	No	0	4	5
30	R:R:F154	R:R:S153	24.0327	6.61	Yes	No	5	4	7
31	R:R:S153	R:R:V101	33.1667	3.23	No	No	0	7	5
32	L:L:?1	R:R:V101	31.0138	12.67	Yes	No	0	0	5
33	L:L:?1	R:R:D100	34.6955	6.92	Yes	Yes	1	0	7
34	R:R:K174	R:R:V185	22.8386	3.04	No	No	0	3	3
35	R:R:V185	R:R:Y183	28.5375	5.05	No	No	0	3	4
36	R:R:R173	R:R:Y183	33.818	8.23	No	No	0	3	4
37	R:R:M187	R:R:R173	62.1792	2.48	Yes	No	0	3	3
38	R:R:I170	R:R:M187	52.7805	5.83	No	Yes	0	4	3
39	R:R:I170	R:R:N163	28.3159	7.08	No	Yes	0	4	5
40	R:R:N162	R:R:N163	33.7796	13.62	No	Yes	6	5	5
41	R:R:N162	R:R:Y192	37.5201	4.65	No	Yes	0	5	7
42	R:R:V188	R:R:Y192	57.1044	5.05	Yes	Yes	0	4	7
43	L:L:?1	R:R:V188	57.0637	3.8	Yes	Yes	1	0	4
44	R:R:I166	R:R:I170	28.3656	5.89	No	No	0	2	4
45	R:R:I166	R:R:N189	60.1167	4.25	No	Yes	0	2	4
46	R:R:N189	R:R:Y192	70.9853	3.49	Yes	Yes	0	4	7
47	R:R:M187	R:R:Y287	26.4411	8.38	Yes	No	0	3	3
48	R:R:I166	R:R:Y287	29.9894	6.04	No	No	0	2	3
49	R:R:C196	R:R:Y192	56.0008	9.41	No	Yes	0	5	7
50	L:L:?1	R:R:C196	68.8075	6.75	Yes	No	0	0	5
51	R:R:C196	R:R:I152	16.5381	4.91	No	No	0	5	5
52	R:R:I152	R:R:T105	13.4512	7.6	No	Yes	0	5	6
53	R:R:T104	R:R:W272	68.2286	7.28	No	Yes	1	7	8
54	R:R:F268	R:R:W272	29.5665	5.01	Yes	Yes	1	9	8
55	R:R:F268	R:R:M208	40.849	9.95	Yes	Yes	1	9	8
56	R:R:M208	R:R:Y212	32.6421	3.59	Yes	Yes	1	8	9
57	R:R:Y120	R:R:Y129	17.393	3.97	Yes	Yes	2	4	7
58	R:R:L169	R:R:M187	11.4272	4.24	No	Yes	0	1	3
59	R:R:N176	R:R:R173	22.8386	6.03	No	No	0	5	3
60	R:R:F175	R:R:K174	11.4272	1.24	No	No	0	1	3
61	R:R:N176	R:R:N178	11.4272	1.36	No	No	0	5	3
62	L:L:?1	R:R:N279	18.2885	12.85	Yes	Yes	1	0	5
63	R:R:F201	R:R:F276	16.8502	21.43	Yes	No	0	8	7
64	L:L:?1	R:R:F276	82.7631	9.32	Yes	No	0	0	7
65	R:R:N304	R:R:W272	100	14.69	No	Yes	1	9	8
66	R:R:F297	R:R:T278	16.0338	9.08	Yes	Yes	0	6	4
67	R:R:T278	R:R:W294	20.4754	4.85	Yes	Yes	1	4	4
68	R:R:F275	R:R:W294	21.3958	5.01	No	Yes	0	6	4
69	R:R:V69	R:R:V73	28.1757	4.81	Yes	No	0	8	7
70	R:R:Y212	R:R:Y312	27.3254	3.97	Yes	Yes	0	9	9
71	R:R:N304	R:R:N308	99.3781	8.17	No	Yes	1	9	9
72	L:L:?1	R:R:T104	66.5528	8.77	Yes	No	1	0	7
73	R:R:F276	R:R:W272	66.9757	4.01	No	Yes	0	7	8
74	R:R:F201	R:R:F268	14.3875	4.29	Yes	Yes	1	8	9
75	L:L:?1	R:R:F275	18.2908	13.47	Yes	No	0	0	6
76	R:R:N279	R:R:W294	19.2383	4.52	Yes	Yes	1	5	4
77	R:R:D100	R:R:V73	25.7921	7.3	Yes	No	1	7	7
78	R:R:L62	R:R:N308	41.0706	5.49	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D100	R:R:V73	7.3	1	Yes	No	7	7	1	2
R:R:V73	R:R:Y302	5.05	1	No	Yes	7	7	2	2
R:R:D100	R:R:T104	4.34	1	Yes	No	7	7	1	1
R:R:D100	R:R:Y302	11.49	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:D100	6.92	1	Yes	Yes	0	7	0	1
R:R:S153	R:R:V101	3.23	5	No	No	7	5	2	1
R:R:I157	R:R:V101	4.61	0	No	No	5	5	2	1
L:L:?1	R:R:V101	12.67	1	Yes	No	0	5	0	1
R:R:T104	R:R:W272	7.28	1	No	Yes	7	8	1	2
L:L:?1	R:R:T104	8.77	1	Yes	No	0	7	0	1
R:R:C196	R:R:I152	4.91	0	No	No	5	5	1	2
R:R:F186	R:R:I157	5.02	0	No	No	4	5	2	2
R:R:I157	R:R:Y192	6.04	0	No	Yes	5	7	2	2
R:R:F186	R:R:V188	3.93	0	No	Yes	4	4	2	1
R:R:V188	R:R:Y192	5.05	1	Yes	Yes	4	7	1	2
R:R:A193	R:R:V188	3.39	0	No	Yes	5	4	2	1
R:R:N279	R:R:V188	4.43	1	Yes	Yes	5	4	1	1
L:L:?1	R:R:V188	3.8	1	Yes	Yes	0	4	0	1
R:R:C196	R:R:Y192	9.41	0	No	Yes	5	7	1	2
L:L:?1	R:R:C196	6.75	1	Yes	No	0	5	0	1
R:R:N279	R:R:S197	5.96	1	Yes	No	5	6	1	2
R:R:F201	R:R:F276	21.43	1	Yes	No	8	7	2	1
R:R:F276	R:R:W272	4.01	0	No	Yes	7	8	1	2
R:R:F275	R:R:W294	5.01	0	No	Yes	6	4	1	2
R:R:F275	R:R:L298	4.87	0	No	No	6	5	1	2
L:L:?1	R:R:F275	13.47	1	Yes	No	0	6	0	1
L:L:?1	R:R:F276	9.32	1	Yes	No	0	7	0	1
R:R:N279	R:R:W294	4.52	1	Yes	Yes	5	4	1	2
L:L:?1	R:R:N279	12.85	1	Yes	Yes	0	5	0	1
R:R:L298	R:R:Y302	15.24	0	No	Yes	5	7	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XTA_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.22
Number of Linked Nodes	258
Number of Links	298
Number of Hubs	42
Number of Links mediated by Hubs	165
Number of Communities	6
Number of Nodes involved in Communities	58
Number of Links involved in Communities	78

Path Summary
Number Of Nodes in MetaPath	79
Number Of Links MetaPath	78
Number of Shortest Paths	107710
Length Of Smallest Path	3
Average Path Length	15.0534
Length of Longest Path	32
Minimum Path Strength	1.265
Average Path Strength	6.36065
Maximum Path Strength	15.375
Minimum Path Correlation	0.7
Average Path Correlation	0.929508
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	47.0023
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5839
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle
Gene Ontology	Cellular Component	• midbody • cellular anatomical structure • membrane-bounded organelle • intracellular anatomical structure • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell periphery • cell cortex • cytoplasm • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • serotonin binding • amine binding • heterocyclic compound binding • neurotransmitter receptor activity • molecular transducer activity • signaling receptor activity • serotonin receptor activity • transmembrane signaling receptor activity • G protein-coupled amine receptor activity • G protein-coupled serotonin receptor activity • G protein-coupled receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • multicellular organismal process • maintenance of gastrointestinal epithelium • system process • digestion • multicellular organismal-level homeostasis • epithelial structure maintenance • homeostatic process • digestive system process • anatomical structure homeostasis • tissue homeostasis • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of body fluid levels • secretion by tissue • secretion • transport • mucus secretion • establishment of localization • body fluid secretion • localization • regulation of biological quality • adenylate cyclase-activating G protein-coupled receptor signaling pathway • large intestinal transit • intestinal motility • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-activating serotonin receptor signaling pathway • regulation of cellular component organization • cellular component organization • cellular component biogenesis • multicellular organism development • cellular component assembly • regulation of postsynapse assembly • cell junction assembly • anatomical structure development • regulation of synapse structure or activity • synapse organization • cellular component organization or biogenesis • regulation of synapse assembly • system development • developmental process • postsynapse organization • postsynapse assembly • regulation of postsynapse organization • nervous system development • regulation of cellular component biogenesis • regulation of cell junction assembly • regulation of synapse organization • cell junction organization • synapse assembly • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • response to nutrient levels • regulation of appetite • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • periplasmic space • somatodendritic compartment • dendrite • dendritic tree • neuron projection • synapse • cell junction • glutamatergic synapse • endosome membrane • endosome • intracellular vesicle • cytoplasmic vesicle membrane • vesicle membrane • cytoplasmic vesicle • postsynapse • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	SRO
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	SRO
Name	Serotonin
Synonyms	thrombotonin
Identifier
Formula	C10 H12 N2 O
Molecular Weight	176.215
SMILES
PubChem	5202
Formal Charge	0
Total Atoms	25
Total Chiral Atoms	0
Total Bonds	26
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q13639
Sequence	>7XTA_nogp_Chain_R K V V L L T F L S T V I L M A I L G N L L V M V A V C W D R Q L R K I K T N Y F I V S L A F A D L L V S V L V M P F G A I E L V Q D I W I Y G E V F C L V R T S L D V L L T T A S I F H L C C I S L D R Y Y A I C C Q P L V Y R N K M T P L R I A L M L G G C W V I P T F I S F L P I M Q G W N N I G I I D L I E K R K F N Q N S N S T Y C V F M V N K P Y A I T C S V V A F Y I P F L L M V L A Y Y R I Y V T A K E H A H Q I T K A A K T L C I I M G C F C L C W A P F F V T N I V D P F I D Y T V P G Q V W T A F L W L G Y I N S G L N P F L Y A F L N K S F R R A F L I I L C C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XT8	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-	Gs/β1/γ2	3.1	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XT8 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-		3.1	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XT9	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-	Gs/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XT9 (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTA	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-	Gi1/β1/γ2	3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031
	7XTA (No Gprot)	A	Amine	5-Hydroxytryptamine	5-HT₄	Homo sapiens	Serotonin	-		3.2	2022-07-27	doi.org/10.1016/j.molcel.2022.05.031

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