psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:Q14	R:R:C30	3.05	No	No	0	0	7
2	R:R:F33	R:R:Q334	10.54	Yes	No	0	6	5
3	R:R:F33	R:R:I338	10.05	Yes	No	0	6	6
4	R:R:L35	R:R:V39	2.98	No	No	0	6	8
5	R:R:L38	R:R:T42	2.95	No	Yes	8	6	6
6	R:R:L38	R:R:W99	18.22	No	Yes	8	6	6
7	R:R:P40	R:R:V39	3.53	No	No	0	5	8
8	R:R:Q342	R:R:V41	4.3	Yes	No	0	6	7
9	R:R:L46	R:R:T42	2.95	No	Yes	0	4	6
10	R:R:L95	R:R:T42	5.9	Yes	Yes	0	7	6
11	R:R:T42	R:R:W99	9.7	Yes	Yes	8	6	6
12	R:R:L48	R:R:V44	2.98	No	No	0	6	5
13	R:R:Q342	R:R:V44	5.73	Yes	No	0	6	5
14	R:R:C45	R:R:L95	4.76	No	Yes	0	7	7
15	R:R:C45	R:R:Q342	6.1	No	Yes	0	7	6
16	R:R:L346	R:R:L48	4.15	No	No	0	7	6
17	R:R:F49	R:R:V53	7.87	Yes	No	3	6	7
18	R:R:F49	R:R:L88	3.65	Yes	No	3	6	6
19	R:R:F49	R:R:L91	7.31	Yes	Yes	3	6	8
20	R:R:F49	R:R:P92	5.78	Yes	No	3	6	9
21	R:R:S349	R:R:V51	3.23	No	No	0	8	5
22	R:R:G52	R:R:S349	3.71	No	No	0	8	8
23	R:R:L88	R:R:V53	2.98	No	No	3	6	7
24	R:R:G55	R:R:S54	3.71	No	No	0	9	5
25	R:R:A81	R:R:N56	4.69	No	Yes	0	9	9
26	R:R:D84	R:R:N56	4.04	No	Yes	0	9	9
27	R:R:L85	R:R:N56	8.24	No	Yes	0	7	9
28	R:R:N56	R:R:P352	3.26	Yes	Yes	0	9	9
29	R:R:L62	R:R:V58	2.98	Yes	No	4	8	6
30	R:R:V58	R:R:Y362	3.79	No	Yes	4	6	9
31	R:R:I63	R:R:T59	3.04	No	Yes	0	8	9
32	R:R:A81	R:R:T59	3.36	No	Yes	0	9	9
33	R:R:N356	R:R:T59	11.7	Yes	Yes	4	8	9
34	R:R:T59	R:R:Y362	8.74	Yes	Yes	4	9	9
35	R:R:L62	R:R:Y362	7.03	Yes	Yes	4	8	9
36	R:R:L369	R:R:L62	5.54	No	Yes	0	5	8
37	R:R:R65	R:R:Y66	10.29	No	Yes	0	6	5
38	R:R:M69	R:R:Y66	3.59	Yes	Yes	0	8	5
39	R:R:K368	R:R:Y66	11.94	No	Yes	0	6	5
40	R:R:L369	R:R:Y66	5.86	No	Yes	0	5	5
41	R:R:R67	R:R:R70	11.73	No	No	0	6	8
42	R:R:R152	R:R:R67	4.26	No	No	0	5	6
43	R:R:D68	R:R:M69	5.54	No	Yes	0	6	8
44	R:R:M69	R:R:N74	5.61	Yes	No	0	8	8
45	R:R:A365	R:R:M69	3.22	No	Yes	0	7	8
46	R:R:L75	R:R:R70	3.64	No	No	0	6	8
47	R:R:N74	R:R:T71	10.24	No	No	0	8	8
48	R:R:E135	R:R:T72	9.88	No	No	0	8	7
49	R:R:T72	R:R:V155	9.52	No	Yes	0	7	7
50	R:R:L77	R:R:T73	2.95	No	No	0	9	8
51	R:R:L132	R:R:T73	4.42	No	No	0	8	8
52	R:R:E135	R:R:T73	4.23	No	No	0	8	8
53	R:R:L75	R:R:R152	4.86	No	No	0	6	5
54	R:R:A131	R:R:Y76	5.34	No	Yes	0	8	8
55	R:R:E135	R:R:Y76	4.49	No	Yes	0	8	8
56	R:R:V155	R:R:Y76	5.05	Yes	Yes	9	7	8
57	R:R:L158	R:R:Y76	3.52	No	Yes	0	5	8
58	R:R:I159	R:R:Y76	13.3	No	Yes	9	8	8
59	R:R:L77	R:R:Y355	3.52	No	Yes	0	9	9
60	R:R:L77	R:R:N356	12.36	No	Yes	0	9	8
61	R:R:H128	R:R:S79	8.37	No	No	5	8	9
62	R:R:S79	R:R:W163	6.18	No	Yes	5	9	9
63	R:R:M80	R:R:T125	6.02	No	Yes	10	9	9
64	R:R:M129	R:R:M80	5.78	No	No	10	7	9
65	R:R:M80	R:R:N351	8.41	No	Yes	0	9	9
66	R:R:L86	R:R:V82	2.98	No	No	0	7	7
67	R:R:S83	R:R:T125	3.2	No	Yes	0	9	9
68	R:R:S83	R:R:W163	6.18	No	Yes	0	9	9
69	R:R:D84	R:R:T125	5.78	No	Yes	0	9	9
70	R:R:D84	R:R:N351	6.73	No	Yes	0	9	9
71	R:R:L85	R:R:L89	4.15	No	No	0	7	6
72	R:R:C121	R:R:L86	4.76	No	No	0	8	7
73	R:R:C121	R:R:I87	4.91	No	No	0	8	7
74	R:R:I87	R:R:T122	3.04	No	No	11	7	8
75	R:R:F344	R:R:I87	3.77	No	No	11	9	7
76	R:R:L91	R:R:P92	4.93	Yes	No	3	8	9
77	R:R:L91	R:R:L95	5.54	Yes	Yes	0	8	7
78	R:R:L91	R:R:Y345	15.24	Yes	No	0	8	8
79	R:R:F106	R:R:F93	4.29	Yes	No	12	7	6
80	R:R:F93	R:R:L110	4.87	No	No	12	6	6
81	R:R:D94	R:R:R97	8.34	No	Yes	0	7	6
82	R:R:L95	R:R:L98	4.15	Yes	No	0	7	6
83	R:R:F106	R:R:Y96	5.16	Yes	No	0	7	5
84	R:R:R97	R:R:S114	3.95	Yes	No	0	6	6
85	R:R:E234	R:R:R97	10.47	No	Yes	0	4	6
86	R:R:C235	R:R:R97	5.57	No	Yes	0	9	6
87	R:R:L98	R:R:W99	4.56	No	Yes	0	6	6
88	L:L:T6	R:R:S101	6.4	No	No	0	0	5
89	R:R:F231	R:R:R102	10.69	No	No	0	4	6
90	L:L:Y7	R:R:R102	6.17	No	No	0	0	6
91	R:R:F231	R:R:P103	7.22	No	No	0	4	7
92	R:R:F106	R:R:W104	3.01	Yes	No	0	7	8
93	R:R:R233	R:R:W104	4	No	No	0	4	8
94	R:R:E180	R:R:V105	5.7	Yes	No	0	4	5
95	R:R:E234	R:R:V105	9.98	No	No	0	4	5
96	R:R:C235	R:R:V105	5.12	No	No	0	9	5
97	R:R:F106	R:R:L110	4.87	Yes	No	12	7	6
98	R:R:G107	R:R:P108	4.06	No	No	13	9	3
99	R:R:E180	R:R:G107	4.91	Yes	No	13	4	9
100	R:R:E180	R:R:P108	4.72	Yes	No	13	4	3
101	R:R:C111	R:R:L115	3.17	No	Yes	0	9	5
102	R:R:C111	R:R:G178	3.92	No	No	0	9	5
103	R:R:C111	R:R:C235	7.28	No	No	0	9	9
104	R:R:G178	R:R:R112	3	No	No	0	5	8
105	R:R:R112	R:R:V179	6.54	No	No	0	8	6
106	R:R:L115	R:R:S114	4.5	Yes	No	0	5	6
107	R:R:L115	R:R:V177	2.98	Yes	No	0	5	6
108	L:L:F1	R:R:L115	4.87	No	Yes	0	0	5
109	R:R:L167	R:R:Y116	7.03	No	No	0	4	6
110	R:R:G171	R:R:Y116	2.9	No	No	0	5	6
111	R:R:L174	R:R:Y116	15.24	No	No	0	5	6
112	R:R:E119	R:R:Y123	15.71	Yes	Yes	0	6	7
113	R:R:A170	R:R:E119	3.02	No	Yes	0	8	6
114	R:R:E119	R:R:F173	8.16	Yes	No	0	6	5
115	R:R:E119	R:R:R318	5.82	Yes	Yes	0	6	7
116	R:R:F344	R:R:T122	3.89	No	No	11	9	8
117	R:R:S169	R:R:Y123	7.63	No	Yes	15	6	7
118	R:R:T252	R:R:Y123	6.24	No	Yes	0	7	7
119	R:R:Y123	R:R:Y255	10.92	Yes	No	15	7	7
120	R:R:A124	R:R:H128	2.93	No	No	5	8	8
121	R:R:A124	R:R:W163	5.19	No	Yes	5	8	9
122	R:R:M129	R:R:T125	4.52	No	Yes	10	7	9
123	R:R:L126	R:R:W311	12.53	No	Yes	0	7	8
124	R:R:L127	R:R:L162	11.07	No	No	0	7	8
125	R:R:H128	R:R:W163	9.52	No	Yes	5	8	9
126	R:R:P259	R:R:T130	3.5	No	No	0	9	7
127	R:R:C262	R:R:T130	3.38	No	No	0	6	7
128	R:R:L132	R:R:R136	15.79	No	No	0	8	9
129	R:R:L263	R:R:S133	9.01	No	No	2	8	9
130	R:R:S133	R:R:Y267	6.36	No	Yes	2	9	8
131	R:R:L138	R:R:V134	2.98	No	No	0	5	7
132	R:R:L266	R:R:V134	2.98	No	No	0	7	7
133	R:R:R136	R:R:Y355	6.17	No	Yes	0	9	9
134	R:R:L138	R:R:Y137	3.52	No	Yes	0	5	7
135	R:R:C141	R:R:Y137	8.06	Yes	Yes	0	7	7
136	R:R:L266	R:R:Y137	11.72	No	Yes	0	7	7
137	R:R:L269	R:R:Y137	8.21	No	Yes	0	5	7
138	R:R:I140	R:R:I270	2.94	Yes	Yes	6	8	8
139	R:R:R153	R:R:R156	5.33	No	No	0	4	4
140	R:R:L158	R:R:R154	3.64	No	No	0	5	6
141	R:R:I159	R:R:V155	3.07	No	Yes	9	8	7
142	R:R:L158	R:R:L162	4.15	No	No	0	5	8
143	R:R:L167	R:R:W163	4.56	No	Yes	0	4	9
144	R:R:S169	R:R:Y255	5.09	No	No	15	6	7
145	R:R:G171	R:R:P172	4.06	No	No	0	5	9
146	R:R:L176	R:R:P172	3.28	No	No	0	5	9
147	R:R:M248	R:R:P172	3.35	No	No	0	6	9
148	R:R:F173	R:R:M248	11.2	No	No	0	5	6
149	R:R:F175	R:R:L174	3.65	No	No	0	5	5
150	R:R:A244	R:R:L176	3.15	No	No	0	5	5
151	R:R:P237	R:R:V177	3.53	No	No	14	5	6
152	R:R:L245	R:R:V177	2.98	No	No	14	4	6
153	R:R:E180	R:R:R233	5.82	Yes	No	0	4	4
154	R:R:P239	R:R:Q181	7.9	No	No	0	7	4
155	L:L:R12	R:R:D182	8.34	No	No	0	0	4
156	R:R:A227	R:R:L230	3.15	No	No	0	3	2
157	L:L:T6	R:R:R236	14.23	No	No	1	0	5
158	L:L:G8	R:R:R236	4.5	No	No	0	0	5
159	L:L:E9	R:R:R236	10.47	No	No	1	0	5
160	R:R:L245	R:R:P237	3.28	No	No	14	4	5
161	R:R:P239	R:R:S238	5.34	No	No	0	7	5
162	R:R:Q241	R:R:S238	10.11	No	No	0	4	5
163	R:R:L245	R:R:L249	6.92	No	No	0	4	5
164	R:R:R246	R:R:W250	13	Yes	No	7	5	5
165	R:R:I322	R:R:R246	6.26	Yes	Yes	7	6	5
166	R:R:N323	R:R:R246	12.05	Yes	Yes	7	5	5
167	R:R:L249	R:R:R318	4.86	No	Yes	0	5	7
168	R:R:I322	R:R:W250	5.87	Yes	No	7	6	5
169	R:R:N323	R:R:W250	3.39	Yes	No	7	5	5
170	R:R:R318	R:R:T252	3.88	Yes	No	0	7	7
171	R:R:F257	R:R:T253	6.49	No	No	0	5	6
172	R:R:F256	R:R:F257	3.22	No	No	0	8	5
173	R:R:F256	R:R:L312	6.09	No	No	0	8	6
174	R:R:F256	R:R:H315	13.58	No	No	0	8	8
175	R:R:F260	R:R:I308	6.28	No	No	0	7	7
176	R:R:L263	R:R:Y267	11.72	No	Yes	2	8	8
177	R:R:F307	R:R:L263	3.65	No	No	0	9	8
178	R:R:L300	R:R:Y267	10.55	No	Yes	0	9	8
179	R:R:V304	R:R:Y267	5.05	Yes	Yes	2	8	8
180	R:R:R272	R:R:S276	5.27	No	No	0	5	3
181	R:R:H293	R:R:L274	10.29	No	Yes	0	7	8
182	R:R:L274	R:R:T296	2.95	Yes	No	0	8	7
183	R:R:Q295	R:R:V299	7.16	No	No	0	8	8
184	R:R:L300	R:R:T296	2.95	No	No	0	9	7
185	R:R:I358	R:R:V299	6.14	No	No	0	7	8
186	R:R:L301	R:R:L305	5.54	No	No	2	6	6
187	R:R:L354	R:R:V303	2.98	Yes	No	0	8	8
188	R:R:V303	R:R:Y355	3.79	No	Yes	0	8	9
189	R:R:I308	R:R:V304	3.07	No	Yes	0	7	8
190	R:R:F307	R:R:W311	18.04	No	Yes	0	9	8
191	R:R:C310	R:R:S347	6.89	No	No	0	9	9
192	R:R:F344	R:R:W311	5.01	No	Yes	0	9	8
193	R:R:L312	R:R:P313	3.28	No	No	0	6	9
194	R:R:L312	R:R:V316	2.98	No	No	0	6	6
195	R:R:L343	R:R:P313	3.28	No	No	0	8	9
196	R:R:F314	R:R:H315	9.05	No	No	0	6	8
197	R:R:F314	R:R:R318	19.24	No	Yes	0	6	7
198	R:R:I320	R:R:V316	3.07	Yes	No	1	6	6
199	R:R:F336	R:R:V316	6.55	Yes	No	1	5	6
200	R:R:G317	R:R:I320	3.53	No	Yes	1	6	6
201	R:R:F336	R:R:G317	4.52	Yes	No	1	5	6
202	R:R:G317	R:R:N337	3.39	No	Yes	1	6	6
203	L:L:P3	R:R:R318	7.21	Yes	Yes	0	0	7
204	R:R:F336	R:R:I320	3.77	Yes	Yes	1	5	6
205	L:L:P3	R:R:Y321	16.69	Yes	No	0	0	5
206	L:L:F5	R:R:Y321	14.44	Yes	No	0	0	5
207	R:R:I322	R:R:N323	5.66	Yes	Yes	7	6	5
208	R:R:S333	R:R:T324	3.2	Yes	No	1	7	4
209	L:L:F5	R:R:T324	5.19	Yes	No	1	0	4
210	R:R:D326	R:R:E325	3.9	Yes	No	0	5	3
211	R:R:D326	R:R:S327	4.42	Yes	No	16	5	5
212	R:R:D326	R:R:R328	10.72	Yes	No	0	5	4
213	L:L:E17	R:R:D326	5.2	No	Yes	16	0	5
214	L:L:E17	R:R:S327	8.62	No	No	16	0	5
215	R:R:M330	R:R:S333	3.07	No	Yes	1	4	7
216	L:L:F5	R:R:M330	17.42	Yes	No	1	0	4
217	L:L:M13	R:R:M330	5.78	No	No	0	0	4
218	R:R:Y331	R:R:Y335	15.89	No	No	0	3	4
219	R:R:F332	R:R:F336	4.29	No	Yes	0	4	5
220	R:R:N337	R:R:S333	2.98	Yes	Yes	1	6	7
221	L:L:F5	R:R:S333	5.28	Yes	Yes	1	0	7
222	L:L:F5	R:R:Q334	4.68	Yes	No	0	0	5
223	L:L:L10	R:R:Q334	5.32	No	No	0	0	5
224	L:L:V2	R:R:N337	2.96	Yes	Yes	1	0	6
225	L:L:P3	R:R:N337	6.52	Yes	Yes	1	0	6
226	R:R:L343	R:R:V339	2.98	No	No	0	8	6
227	R:R:L341	R:R:Q342	3.99	No	Yes	0	6	6
228	R:R:L341	R:R:Y345	7.03	No	No	0	6	8
229	L:L:V2	R:R:L341	10.43	Yes	No	0	0	6
230	R:R:I350	R:R:I353	4.42	No	No	0	7	8
231	R:R:I350	R:R:L354	11.42	No	Yes	0	7	8
232	R:R:N351	R:R:P352	4.89	Yes	Yes	0	9	9
233	R:R:N351	R:R:Y355	8.14	Yes	Yes	0	9	9
234	R:R:I353	R:R:P352	5.08	No	Yes	0	8	9
235	R:R:N356	R:R:P352	3.26	Yes	Yes	0	8	9
236	R:R:I353	R:R:L357	4.28	No	No	0	8	6
237	R:R:N356	R:R:Y362	16.28	Yes	Yes	4	8	9
238	R:R:L357	R:R:Y362	3.52	No	Yes	0	6	9
239	R:R:K360	R:R:R363	7.43	No	No	0	4	9
240	L:L:F1	L:L:P3	10.11	No	Yes	0	0	0
241	L:L:P3	L:L:V2	3.53	Yes	Yes	1	0	0
242	L:L:I4	L:L:V2	3.07	No	Yes	0	0	0
243	L:L:E9	L:L:F5	4.66	No	Yes	1	0	0
244	L:L:E9	L:L:T6	8.47	No	No	1	0	0
245	L:L:Q11	L:L:Y7	6.76	No	No	0	0	0
246	L:L:G8	L:L:Q11	4.93	No	No	0	0	0
247	L:L:E15	L:L:R18	5.82	No	No	0	0	0
248	R:R:F33	R:R:P32	2.89	Yes	No	0	6	3
249	R:R:P103	R:R:R100	2.88	No	No	0	7	5
250	R:R:Q181	R:R:V179	2.87	No	No	0	4	6
251	R:R:I140	R:R:L274	2.85	Yes	Yes	6	8	8
252	R:R:I322	R:R:L249	2.85	Yes	No	0	6	5
253	R:R:I265	R:R:L269	2.85	No	No	0	4	5
254	R:R:I270	R:R:L274	2.85	Yes	Yes	6	8	8
255	R:R:I270	R:R:L300	2.85	Yes	No	0	8	9
256	R:R:Q295	R:R:T296	2.83	No	No	0	8	7
257	R:R:I319	R:R:N323	2.83	No	Yes	0	6	5
258	R:R:A157	R:R:R153	2.77	No	No	0	3	4
259	L:L:E17	L:L:M13	2.71	No	No	0	0	0
260	R:R:F307	R:R:M129	2.49	No	No	0	9	7
261	R:R:S276	R:R:W275	2.47	No	No	0	3	3
262	R:R:V297	R:R:W275	2.45	No	No	0	7	3
263	R:R:F260	R:R:L261	2.44	No	No	0	7	4
264	R:R:L35	R:R:W99	2.28	No	Yes	0	6	6
265	R:R:G55	R:R:P352	2.03	No	Yes	0	9	9
266	R:R:G90	R:R:P92	2.03	No	No	0	7	9
267	R:R:A81	R:R:G78	1.95	No	No	0	9	7
268	R:R:A170	R:R:G120	1.95	No	No	0	8	5
269	L:L:G8	R:R:S232	1.86	No	No	0	0	3
270	R:R:G118	R:R:V117	1.84	No	No	0	7	6
271	R:R:G271	R:R:V297	1.84	No	No	0	6	7
272	R:R:A124	R:R:A166	1.79	No	No	0	8	8
273	R:R:P32	R:R:S31	1.78	No	No	0	3	7
274	R:R:G52	R:R:L88	1.71	No	No	0	8	6
275	R:R:C141	R:R:I140	1.64	Yes	Yes	6	7	8
276	R:R:C141	R:R:I270	1.64	Yes	Yes	6	7	8
277	R:R:L258	R:R:P259	1.64	No	No	0	5	9
278	R:R:A139	R:R:I140	1.62	No	Yes	0	8	8
279	R:R:V53	R:R:V57	1.6	No	No	0	7	5
280	R:R:V60	R:R:V82	1.6	No	No	0	7	7
281	R:R:V150	R:R:V155	1.6	No	Yes	0	6	7
282	R:R:V161	R:R:V165	1.6	No	No	0	4	5
283	L:L:L10	R:R:C30	1.59	No	No	0	0	7
284	R:R:T130	R:R:V134	1.59	No	No	0	7	7
285	R:R:A366	R:R:L62	1.58	No	Yes	0	7	8
286	R:R:A306	R:R:L354	1.58	No	Yes	0	7	8
287	R:R:I358	R:R:S359	1.55	No	No	0	7	9
288	R:R:C141	R:R:E273	1.52	Yes	No	0	7	5
289	R:R:G243	R:R:R246	1.5	No	Yes	0	1	5
290	R:R:L113	R:R:V117	1.49	No	No	0	5	6
291	R:R:L127	R:R:V165	1.49	No	No	0	7	5
292	R:R:L301	R:R:V304	1.49	No	Yes	2	6	8
293	R:R:L354	R:R:V302	1.49	Yes	No	0	8	6
294	R:R:L305	R:R:V304	1.49	No	Yes	2	6	8
295	R:R:I320	R:R:M329	1.46	Yes	No	0	6	3
296	R:R:F33	R:R:P34	1.44	Yes	No	0	6	8
297	R:R:K361	R:R:M69	1.44	No	Yes	0	7	8
298	R:R:P143	R:R:R142	1.44	No	No	0	8	6
299	R:R:I159	R:R:L75	1.43	No	No	0	8	6
300	R:R:L369	R:R:M61	1.41	No	No	0	5	4
301	R:R:A340	R:R:F314	1.39	No	No	0	7	6
302	R:R:L113	R:R:L174	1.38	No	No	0	5	5
303	R:R:A160	R:R:R156	1.38	No	No	0	4	4
304	R:R:F49	R:R:V50	1.31	Yes	No	0	6	6
305	R:R:D182	R:R:Q181	1.31	No	No	0	4	4
306	R:R:C310	R:R:W311	1.31	No	Yes	0	9	8
307	R:R:R153	R:R:T151	1.29	No	No	0	4	8
308	R:R:R154	R:R:T151	1.29	No	No	0	6	8
309	R:R:L230	R:R:R233	1.21	No	No	0	2	4
310	R:R:I338	R:R:Y335	1.21	No	No	0	6	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F33	6.23	4	0	6
2	R:R:T42	5.375	4	8	6
3	R:R:F49	5.184	5	3	6
4	R:R:N56	5.0575	4	0	9
5	R:R:T59	6.71	4	4	9
6	R:R:L62	4.2825	4	4	8
7	R:R:Y66	7.92	4	0	5
8	R:R:M69	3.88	5	0	8
9	R:R:Y76	6.34	5	9	8
10	R:R:L91	8.255	4	3	8
11	R:R:L95	5.0875	4	0	7
12	R:R:R97	7.0825	4	0	6
13	R:R:W99	8.69	4	8	6
14	R:R:F106	4.3325	4	12	7
15	R:R:L115	3.88	4	0	5
16	R:R:E119	8.1775	4	0	6
17	R:R:Y123	10.125	4	15	7
18	R:R:T125	4.88	4	10	9
19	R:R:Y137	7.8775	4	0	7
20	R:R:I140	2.2625	4	6	8
21	R:R:C141	3.215	4	6	7
22	R:R:V155	4.81	4	9	7
23	R:R:W163	6.326	5	5	9
24	R:R:E180	5.2875	4	13	4
25	R:R:R246	8.2025	4	7	5
26	R:R:Y267	8.42	4	2	8
27	R:R:I270	2.57	4	6	8
28	R:R:L274	4.735	4	6	8
29	R:R:V304	2.775	4	2	8
30	R:R:W311	9.2225	4	0	8
31	R:R:R318	8.202	5	0	7
32	R:R:I320	2.9575	4	1	6
33	R:R:I322	5.16	4	7	6
34	R:R:N323	5.9825	4	7	5
35	R:R:D326	6.06	4	16	5
36	R:R:S333	3.6325	4	1	7
37	R:R:F336	4.7825	4	1	5
38	R:R:N337	3.9625	4	1	6
39	R:R:Q342	5.03	4	0	6
40	R:R:N351	7.0425	4	0	9
41	R:R:P352	3.704	5	0	9
42	R:R:L354	4.3675	4	0	8
43	R:R:Y355	5.405	4	0	9
44	R:R:N356	10.9	4	4	8
45	R:R:Y362	7.872	5	4	9
46	L:L:V2	4.9975	4	1	0
47	L:L:P3	8.812	5	1	0
48	L:L:F5	8.61167	6	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:F5	R:R:Q334	12.4052	4.68	Yes	No	0	0	5
2	L:L:F5	R:R:Y321	27.6961	14.44	Yes	No	0	0	5
3	L:L:P3	R:R:Y321	28.5802	16.69	Yes	No	0	0	5
4	L:L:P3	L:L:V2	39.6645	3.53	Yes	Yes	1	0	0
5	L:L:V2	R:R:L341	44.1256	10.43	Yes	No	0	0	6
6	R:R:L341	R:R:Q342	18.8436	3.99	No	Yes	0	6	6
7	R:R:C45	R:R:Q342	14.1012	6.1	No	Yes	0	7	6
8	R:R:C45	R:R:L95	13.1688	4.76	No	Yes	0	7	7
9	R:R:L95	R:R:T42	14.1253	5.9	Yes	Yes	0	7	6
10	R:R:L35	R:R:W99	12.1426	2.28	No	Yes	0	6	6
11	R:R:N337	R:R:S333	12.649	2.98	Yes	Yes	1	6	7
12	R:R:L341	R:R:Y345	24.7435	7.03	No	No	0	6	8
13	R:R:L91	R:R:Y345	23.8111	15.24	Yes	No	0	8	8
14	R:R:L91	R:R:L95	13.3778	5.54	Yes	Yes	0	8	7
15	R:R:L95	R:R:L98	10.0903	4.15	Yes	No	0	7	6
16	L:L:P3	R:R:R318	86.9169	7.21	Yes	Yes	0	0	7
17	R:R:E119	R:R:R318	95.2013	5.82	Yes	Yes	0	6	7
18	R:R:E119	R:R:F173	97.1492	8.16	Yes	No	0	6	5
19	R:R:F173	R:R:M248	97.3475	11.2	No	No	0	5	6
20	R:R:M248	R:R:P172	97.5404	3.35	No	No	0	6	9
21	R:R:G171	R:R:P172	98.087	4.06	No	No	0	5	9
22	R:R:G171	R:R:Y116	98.2584	2.9	No	No	0	5	6
23	R:R:L167	R:R:Y116	99.1748	7.03	No	No	0	4	6
24	R:R:L167	R:R:W163	99.3087	4.56	No	Yes	0	4	9
25	R:R:S83	R:R:W163	99.8982	6.18	No	Yes	0	9	9
26	R:R:S83	R:R:T125	100	3.2	No	Yes	0	9	9
27	R:R:M80	R:R:T125	27.3585	6.02	No	Yes	10	9	9
28	R:R:M80	R:R:N351	35.2571	8.41	No	Yes	0	9	9
29	R:R:N351	R:R:P352	24.4005	4.89	Yes	Yes	0	9	9
30	R:R:D84	R:R:T125	49.2592	5.78	No	Yes	0	9	9
31	R:R:D84	R:R:N351	27.0718	6.73	No	Yes	0	9	9
32	R:R:D84	R:R:N56	21.9918	4.04	No	Yes	0	9	9
33	R:R:N56	R:R:P352	11.0066	3.26	Yes	Yes	0	9	9
34	R:R:N356	R:R:P352	26.2171	3.26	Yes	Yes	0	8	9
35	R:R:N356	R:R:Y362	25.0275	16.28	Yes	Yes	4	8	9
36	R:R:L62	R:R:Y362	28.3445	7.03	Yes	Yes	4	8	9
37	R:R:L369	R:R:L62	24.154	5.54	No	Yes	0	5	8
38	R:R:L369	R:R:Y66	19.8055	5.86	No	Yes	0	5	5
39	R:R:M69	R:R:Y66	13.2492	3.59	Yes	Yes	0	8	5
40	R:R:N351	R:R:Y355	37.146	8.14	Yes	Yes	0	9	9
41	R:R:L77	R:R:Y355	30.0378	3.52	No	Yes	0	9	9
42	R:R:L77	R:R:T73	30.9193	2.95	No	No	0	9	8
43	R:R:E135	R:R:T73	29.8529	4.23	No	No	0	8	8
44	R:R:E135	R:R:Y76	25.2123	4.49	No	Yes	0	8	8
45	R:R:L158	R:R:Y76	13.5841	3.52	No	Yes	0	5	8
46	R:R:M129	R:R:T125	25.7348	4.52	No	Yes	10	7	9
47	R:R:F307	R:R:M129	33.5504	2.49	No	No	0	9	7
48	L:L:F1	L:L:P3	28.2051	10.11	No	Yes	0	0	0
49	L:L:F1	R:R:L115	27.3076	4.87	No	Yes	0	0	5
50	R:R:C111	R:R:L115	22.7179	3.17	No	Yes	0	9	5
51	R:R:C111	R:R:C235	13.2572	7.28	No	No	0	9	9
52	R:R:C235	R:R:V105	12.282	5.12	No	No	0	9	5
53	R:R:E180	R:R:V105	11.363	5.7	Yes	No	0	4	5
54	L:L:E9	L:L:F5	13.4528	4.66	No	Yes	1	0	0
55	L:L:E9	R:R:R236	10.0823	10.47	No	No	1	0	5
56	R:R:F307	R:R:L263	26.9244	3.65	No	No	0	9	8
57	R:R:L263	R:R:Y267	25.6464	11.72	No	Yes	2	8	8
58	R:R:L300	R:R:Y267	21.4238	10.55	No	Yes	0	9	8
59	R:R:I270	R:R:L300	16.025	2.85	Yes	No	0	8	9
60	R:R:C141	R:R:I270	12.7803	1.64	Yes	Yes	6	7	8
61	R:R:C141	R:R:Y137	11.7113	8.06	Yes	Yes	0	7	7
62	L:L:M13	R:R:M330	10.7735	5.78	No	No	0	0	4
63	L:L:P3	R:R:N337	13.7529	6.52	Yes	Yes	1	0	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:Q14	R:R:C30	3.05	0	No	No	0	7	0	1
R:R:F33	R:R:Q334	10.54	0	Yes	No	6	5	2	1
L:L:T6	R:R:S101	6.4	1	No	No	0	5	0	1
R:R:F231	R:R:R102	10.69	0	No	No	4	6	2	1
L:L:Y7	R:R:R102	6.17	0	No	No	0	6	0	1
R:R:C111	R:R:L115	3.17	0	No	Yes	9	5	2	1
R:R:L115	R:R:S114	4.5	0	Yes	No	5	6	1	2
R:R:L115	R:R:V177	2.98	0	Yes	No	5	6	1	2
L:L:F1	R:R:L115	4.87	0	No	Yes	0	5	0	1
R:R:E119	R:R:R318	5.82	0	Yes	Yes	6	7	2	1
L:L:R12	R:R:D182	8.34	0	No	No	0	4	0	1
L:L:T6	R:R:R236	14.23	1	No	No	0	5	0	1
L:L:G8	R:R:R236	4.5	0	No	No	0	5	0	1
L:L:E9	R:R:R236	10.47	1	No	No	0	5	0	1
R:R:L249	R:R:R318	4.86	0	No	Yes	5	7	2	1
R:R:R318	R:R:T252	3.88	0	Yes	No	7	7	1	2
R:R:F314	R:R:R318	19.24	0	No	Yes	6	7	2	1
R:R:G317	R:R:N337	3.39	1	No	Yes	6	6	2	1
L:L:P3	R:R:R318	7.21	1	Yes	Yes	0	7	0	1
L:L:P3	R:R:Y321	16.69	1	Yes	No	0	5	0	1
L:L:F5	R:R:Y321	14.44	1	Yes	No	0	5	0	1
R:R:S333	R:R:T324	3.2	1	Yes	No	7	4	1	1
L:L:F5	R:R:T324	5.19	1	Yes	No	0	4	0	1
R:R:D326	R:R:E325	3.9	16	Yes	No	5	3	1	2
R:R:D326	R:R:S327	4.42	16	Yes	No	5	5	1	1
R:R:D326	R:R:R328	10.72	16	Yes	No	5	4	1	2
L:L:E17	R:R:D326	5.2	16	No	Yes	0	5	0	1
L:L:E17	R:R:S327	8.62	16	No	No	0	5	0	1
R:R:M330	R:R:S333	3.07	1	No	Yes	4	7	1	1
L:L:F5	R:R:M330	17.42	1	Yes	No	0	4	0	1
L:L:M13	R:R:M330	5.78	0	No	No	0	4	0	1
R:R:N337	R:R:S333	2.98	1	Yes	Yes	6	7	1	1
L:L:F5	R:R:S333	5.28	1	Yes	Yes	0	7	0	1
L:L:F5	R:R:Q334	4.68	1	Yes	No	0	5	0	1
L:L:L10	R:R:Q334	5.32	0	No	No	0	5	0	1
L:L:V2	R:R:N337	2.96	1	Yes	Yes	0	6	0	1
L:L:P3	R:R:N337	6.52	1	Yes	Yes	0	6	0	1
R:R:L341	R:R:Q342	3.99	0	No	Yes	6	6	1	2
R:R:L341	R:R:Y345	7.03	0	No	No	6	8	1	2
L:L:V2	R:R:L341	10.43	1	Yes	No	0	6	0	1
L:L:G8	R:R:S232	1.86	0	No	No	0	3	0	1
L:L:L10	R:R:C30	1.59	0	No	No	0	7	0	1
R:R:D182	R:R:Q181	1.31	0	No	No	4	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IBV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.9
Number of Linked Nodes	268
Number of Links	310
Number of Hubs	48
Number of Links mediated by Hubs	169
Number of Communities	16
Number of Nodes involved in Communities	69
Number of Links involved in Communities	81

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	60611
Length Of Smallest Path	3
Average Path Length	18.6292
Length of Longest Path	36
Minimum Path Strength	1.29
Average Path Strength	6.09402
Maximum Path Strength	16.1833
Minimum Path Correlation	0.7
Average Path Correlation	0.930908
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	42.2293
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.6223
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • electron transport chain • metabolic process • cellular process • generation of precursor metabolites and energy • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • signal transduction • cell communication • cellular anatomical structure • periplasmic space • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • molecular function activator activity • signaling receptor binding • signaling receptor activator activity • hormone activity • protein binding • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • motilin receptor binding • G protein-coupled receptor binding • extracellular region • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43193
Sequence	>8IBV_nogp_Chain_R C S P F P L G A L V P V T A V C L C L F V V G V S G N V V T V M L I G R Y R D M R T T T N L Y L G S M A V S D L L I L L G L P F D L Y R L W R S R P W V F G P L L C R L S L Y V G E G C T Y A T L L H M T A L S V E R Y L A I C R P V T R R R V R A L I A V L W A V A L L S A G P F L F L V G V E Q D A E A A A L F S R E C R P S P A Q L G A L R V M L W V T T A Y F F L P F L C L S I L Y G L I G R E L W S G H R Q T V R V L L V V V L A F I I C W L P F H V G R I I Y I N T E D S R M M Y F S Q Y F N I V A L Q L F Y L S A S I N P I L Y N L I S K K Y R A A A F K L L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IBV	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.19	2023-04-12	10.1126/sciadv.ade9020
	8IBV (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-		3.19	2023-04-12	10.1126/sciadv.ade9020
	8IBU	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.51	2023-04-12	10.1126/sciadv.ade9020
	8IBU (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-		3.51	2023-04-12	10.1126/sciadv.ade9020

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