psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F33	4.17	Yes	Yes	1	0	6
2	L:L:?1	R:R:D94	10.22	Yes	No	1	0	7
3	L:L:?1	R:R:R97	12.48	Yes	Yes	1	0	6
4	L:L:?1	R:R:L115	5.69	Yes	No	1	0	5
5	L:L:?1	R:R:E234	5.44	Yes	No	0	0	4
6	L:L:?1	R:R:R236	6.65	Yes	No	0	0	5
7	L:L:?1	R:R:R318	7.49	Yes	Yes	1	0	7
8	L:L:?1	R:R:Y321	16.05	Yes	No	1	0	5
9	L:L:?1	R:R:Q334	11.85	Yes	No	1	0	5
10	L:L:?1	R:R:N337	3.76	Yes	No	1	0	6
11	L:L:?1	R:R:L341	10.42	Yes	No	0	0	6
12	L:L:?1	R:R:F344	3.34	Yes	Yes	0	0	9
13	R:R:F33	R:R:Q334	7.03	Yes	No	1	6	5
14	R:R:F33	R:R:Y335	4.13	Yes	No	0	6	4
15	R:R:F33	R:R:I338	13.82	Yes	No	0	6	6
16	R:R:L38	R:R:T42	2.95	No	Yes	6	6	6
17	R:R:L38	R:R:W99	10.25	No	No	6	6	6
18	R:R:P40	R:R:V39	3.53	No	No	0	5	8
19	R:R:Q342	R:R:V41	5.73	No	No	0	6	7
20	R:R:L95	R:R:T42	2.95	No	Yes	0	7	6
21	R:R:T42	R:R:W99	6.06	Yes	No	6	6	6
22	R:R:C47	R:R:V44	3.42	No	No	0	3	5
23	R:R:Q342	R:R:V44	4.3	No	No	0	6	5
24	R:R:C45	R:R:L91	4.76	No	Yes	0	7	8
25	R:R:C45	R:R:L95	7.94	No	No	0	7	7
26	R:R:C45	R:R:Q342	3.05	No	No	0	7	6
27	R:R:L48	R:R:S349	6.01	No	No	0	6	8
28	R:R:F49	R:R:V53	5.24	No	No	0	6	7
29	R:R:F49	R:R:L91	4.87	No	Yes	0	6	8
30	R:R:L88	R:R:V53	5.96	No	No	0	6	7
31	R:R:A81	R:R:N56	3.13	No	No	0	9	9
32	R:R:D84	R:R:N56	4.04	Yes	No	0	9	9
33	R:R:L85	R:R:N56	8.24	No	No	0	7	9
34	R:R:V58	R:R:Y362	3.79	No	Yes	0	6	9
35	R:R:A81	R:R:T59	3.36	No	No	0	9	9
36	R:R:N356	R:R:T59	4.39	No	No	2	8	9
37	R:R:T59	R:R:Y362	9.99	No	Yes	2	9	9
38	R:R:L62	R:R:Y66	3.52	Yes	Yes	2	8	5
39	R:R:L62	R:R:Y362	8.21	Yes	Yes	2	8	9
40	R:R:A365	R:R:L62	4.73	No	Yes	0	7	8
41	R:R:L369	R:R:L62	4.15	No	Yes	2	5	8
42	R:R:G64	R:R:R70	3	No	No	0	4	8
43	R:R:R65	R:R:Y66	19.55	No	Yes	2	6	5
44	R:R:L369	R:R:R65	4.86	No	No	2	5	6
45	R:R:K368	R:R:Y66	19.11	No	Yes	0	6	5
46	R:R:L369	R:R:Y66	5.86	No	Yes	2	5	5
47	R:R:R67	R:R:R70	13.86	No	No	0	6	8
48	R:R:D68	R:R:K361	4.15	No	No	0	6	7
49	R:R:M69	R:R:N74	8.41	No	No	0	8	8
50	R:R:T71	R:R:T73	3.14	No	No	7	8	8
51	R:R:N74	R:R:T71	7.31	No	No	0	8	8
52	R:R:T72	R:R:V150	3.17	No	No	0	7	6
53	R:R:L132	R:R:T73	5.9	No	No	0	8	8
54	R:R:L77	R:R:N74	4.12	No	No	0	9	8
55	R:R:L75	R:R:V155	4.47	No	No	0	6	7
56	R:R:L132	R:R:Y76	3.52	No	Yes	0	8	8
57	R:R:E135	R:R:Y76	20.2	No	Yes	0	8	8
58	R:R:V155	R:R:Y76	10.09	No	Yes	8	7	8
59	R:R:L158	R:R:Y76	7.03	No	Yes	0	5	8
60	R:R:I159	R:R:Y76	6.04	No	Yes	8	8	8
61	R:R:L77	R:R:N356	10.98	No	No	0	9	8
62	R:R:H128	R:R:S79	9.76	Yes	No	0	8	9
63	R:R:I159	R:R:S79	3.1	No	No	0	8	9
64	R:R:M80	R:R:T125	3.01	No	Yes	0	9	9
65	R:R:H128	R:R:M80	5.25	Yes	No	0	8	9
66	R:R:M80	R:R:N351	8.41	No	Yes	0	9	9
67	R:R:D84	R:R:S83	5.89	Yes	No	4	9	9
68	R:R:S83	R:R:T125	6.4	No	Yes	4	9	9
69	R:R:D84	R:R:T125	4.34	Yes	Yes	4	9	9
70	R:R:A348	R:R:D84	3.09	No	Yes	0	9	9
71	R:R:D84	R:R:N351	6.73	Yes	Yes	4	9	9
72	R:R:D84	R:R:P352	3.22	Yes	No	4	9	9
73	R:R:C121	R:R:L86	4.76	No	No	0	8	7
74	R:R:C121	R:R:I87	4.91	No	No	0	8	7
75	R:R:F344	R:R:I87	6.28	Yes	No	0	9	7
76	R:R:F93	R:R:G90	3.01	No	No	0	6	7
77	R:R:L91	R:R:P92	3.28	Yes	No	0	8	9
78	R:R:L91	R:R:Y345	12.89	Yes	No	0	8	8
79	R:R:D94	R:R:R97	3.57	No	Yes	1	7	6
80	R:R:L115	R:R:R97	3.64	No	Yes	1	5	6
81	R:R:R100	R:R:R102	12.79	No	No	0	5	6
82	R:R:E234	R:R:S101	8.62	No	No	0	4	5
83	R:R:P103	R:R:R102	4.32	No	No	0	7	6
84	R:R:F106	R:R:W104	3.01	No	No	0	7	8
85	R:R:C111	R:R:V105	5.12	No	No	1	9	5
86	R:R:C235	R:R:V105	8.54	No	No	1	9	5
87	R:R:G107	R:R:P108	4.06	No	No	0	9	3
88	R:R:L109	R:R:R112	6.07	No	No	0	3	8
89	R:R:C111	R:R:C235	5.46	No	No	1	9	9
90	R:R:R112	R:R:V179	3.92	No	No	0	8	6
91	R:R:L115	R:R:S114	4.5	No	No	0	5	6
92	R:R:L167	R:R:Y116	9.38	No	Yes	0	4	6
93	R:R:G171	R:R:Y116	2.9	No	Yes	0	5	6
94	R:R:L174	R:R:Y116	14.07	No	Yes	0	5	6
95	R:R:E119	R:R:T122	4.23	Yes	No	1	6	8
96	R:R:E119	R:R:Y123	6.73	Yes	Yes	1	6	7
97	R:R:E119	R:R:F173	18.66	Yes	No	1	6	5
98	R:R:E119	R:R:R318	10.47	Yes	Yes	1	6	7
99	R:R:T122	R:R:Y123	3.75	No	Yes	1	8	7
100	R:R:F344	R:R:T122	3.89	Yes	No	0	9	8
101	R:R:S169	R:R:Y123	3.82	No	Yes	1	6	7
102	R:R:F173	R:R:Y123	7.22	No	Yes	1	5	7
103	R:R:T252	R:R:Y123	6.24	No	Yes	0	7	7
104	R:R:Y123	R:R:Y255	9.93	Yes	No	1	7	7
105	R:R:R318	R:R:Y123	4.12	Yes	Yes	1	7	7
106	R:R:A124	R:R:W163	10.37	No	No	0	8	9
107	R:R:M129	R:R:T125	3.01	No	Yes	0	7	9
108	R:R:L126	R:R:P259	3.28	No	No	0	7	9
109	R:R:L126	R:R:W311	11.39	No	Yes	0	7	8
110	R:R:L127	R:R:L162	9.69	No	No	0	7	8
111	R:R:L127	R:R:V165	2.98	No	No	0	7	5
112	R:R:H128	R:R:L162	9	Yes	No	0	8	8
113	R:R:H128	R:R:W163	4.23	Yes	No	0	8	9
114	R:R:M129	R:R:N351	5.61	No	Yes	0	7	9
115	R:R:L258	R:R:T130	2.95	No	No	9	5	7
116	R:R:P259	R:R:T130	5.25	No	No	9	9	7
117	R:R:C262	R:R:T130	5.07	No	No	0	6	7
118	R:R:A131	R:R:E135	4.53	No	No	0	8	8
119	R:R:L263	R:R:S133	7.51	No	Yes	10	8	9
120	R:R:L266	R:R:S133	3	Yes	Yes	0	7	9
121	R:R:S133	R:R:Y267	3.82	Yes	Yes	10	9	8
122	R:R:L138	R:R:V134	2.98	No	No	0	5	7
123	R:R:L266	R:R:V134	2.98	Yes	No	0	7	7
124	R:R:E135	R:R:R154	9.3	No	No	0	8	6
125	R:R:R136	R:R:Y267	10.29	No	Yes	0	9	8
126	R:R:L138	R:R:Y137	3.52	No	Yes	0	5	7
127	R:R:C141	R:R:Y137	5.38	No	Yes	3	7	7
128	R:R:R142	R:R:Y137	15.43	No	Yes	3	6	7
129	R:R:L266	R:R:Y137	16.41	Yes	Yes	0	7	7
130	R:R:I140	R:R:I270	4.42	No	No	3	8	8
131	R:R:E273	R:R:I140	4.1	No	No	3	5	8
132	R:R:C141	R:R:R142	8.36	No	No	3	7	6
133	R:R:C141	R:R:E273	7.6	No	No	3	7	5
134	R:R:P143	R:R:R142	10.09	No	No	0	8	6
135	R:R:L144	R:R:R147	6.07	No	No	0	6	6
136	R:R:R147	R:R:V148	3.92	No	No	0	6	6
137	R:R:L149	R:R:T151	7.37	No	No	0	4	8
138	R:R:R153	R:R:T151	6.47	No	No	0	4	8
139	R:R:R154	R:R:T151	6.47	No	No	0	6	8
140	R:R:L158	R:R:R154	7.29	No	No	0	5	6
141	R:R:I159	R:R:V155	3.07	No	No	8	8	7
142	R:R:L167	R:R:W163	3.42	No	No	0	4	9
143	R:R:S169	R:R:Y255	7.63	No	No	1	6	7
144	R:R:G171	R:R:P172	4.06	No	No	0	5	9
145	R:R:M248	R:R:P172	3.35	No	No	0	6	9
146	R:R:F173	R:R:M248	7.46	No	No	0	5	6
147	R:R:L176	R:R:P237	3.28	Yes	No	0	5	5
148	R:R:L176	R:R:Q241	5.32	Yes	No	0	5	4
149	R:R:L176	R:R:L245	4.15	Yes	No	0	5	4
150	R:R:E180	R:R:G178	4.91	No	No	0	4	5
151	R:R:E180	R:R:S238	7.19	No	No	0	4	5
152	R:R:P239	R:R:S238	5.34	No	No	0	7	5
153	R:R:L242	R:R:R246	10.93	No	No	0	3	5
154	R:R:G243	R:R:R246	3	No	No	0	1	5
155	R:R:L245	R:R:L249	4.15	No	Yes	0	4	5
156	R:R:L249	R:R:M248	5.65	Yes	No	0	5	6
157	R:R:L249	R:R:T252	4.42	Yes	No	0	5	7
158	R:R:L249	R:R:R318	4.86	Yes	Yes	0	5	7
159	R:R:T253	R:R:W250	7.28	No	No	0	6	5
160	R:R:F256	R:R:F257	4.29	No	No	0	8	5
161	R:R:F256	R:R:L312	6.09	No	No	0	8	6
162	R:R:F256	R:R:H315	15.84	No	No	0	8	8
163	R:R:L258	R:R:P259	6.57	No	No	9	5	9
164	R:R:F260	R:R:I308	7.54	No	No	0	7	7
165	R:R:L263	R:R:Y267	7.03	No	Yes	10	8	8
166	R:R:L263	R:R:V304	2.98	No	No	0	8	8
167	R:R:I265	R:R:S264	3.1	No	No	0	4	6
168	R:R:L300	R:R:Y267	15.24	No	Yes	0	9	8
169	R:R:E273	R:R:I270	4.1	No	No	3	5	8
170	R:R:H293	R:R:L274	12.86	No	No	0	7	8
171	R:R:L274	R:R:T296	4.42	No	No	0	8	7
172	R:R:Q295	R:R:R294	4.67	No	No	0	8	7
173	R:R:Q295	R:R:V299	4.3	No	No	0	8	8
174	R:R:L301	R:R:R298	4.86	No	No	0	6	6
175	R:R:I358	R:R:V299	6.14	No	No	0	7	8
176	R:R:L354	R:R:V303	5.96	Yes	No	0	8	8
177	R:R:V303	R:R:Y355	7.57	No	No	0	8	9
178	R:R:F307	R:R:W311	14.03	No	Yes	0	9	8
179	R:R:C310	R:R:W311	7.84	No	Yes	0	9	8
180	R:R:C310	R:R:S347	5.16	No	No	0	9	9
181	R:R:F344	R:R:W311	3.01	Yes	Yes	0	9	8
182	R:R:L312	R:R:P313	3.28	No	No	0	6	9
183	R:R:L312	R:R:V316	2.98	No	Yes	0	6	6
184	R:R:L343	R:R:P313	3.28	No	No	0	8	9
185	R:R:F314	R:R:H315	3.39	No	No	0	6	8
186	R:R:F314	R:R:R318	16.03	No	Yes	0	6	7
187	R:R:I320	R:R:V316	4.61	Yes	Yes	5	6	6
188	R:R:F336	R:R:V316	7.87	No	Yes	5	5	6
189	R:R:F332	R:R:I320	3.77	No	Yes	5	4	6
190	R:R:F336	R:R:I320	7.54	No	Yes	5	5	6
191	R:R:N337	R:R:Y321	3.49	No	No	1	6	5
192	R:R:I322	R:R:N323	5.66	Yes	No	0	6	5
193	R:R:M329	R:R:T324	3.01	No	No	0	3	4
194	R:R:M330	R:R:T324	6.02	No	No	0	4	4
195	R:R:S333	R:R:T324	3.2	No	No	0	7	4
196	R:R:D326	R:R:S327	2.94	No	No	0	5	5
197	R:R:Y331	R:R:Y335	24.82	No	No	0	3	4
198	R:R:F332	R:R:F336	4.29	No	No	5	4	5
199	R:R:L343	R:R:V339	2.98	No	No	0	8	6
200	R:R:L341	R:R:Y345	5.86	No	No	0	6	8
201	R:R:F344	R:R:Y345	8.25	Yes	No	0	9	8
202	R:R:I350	R:R:L346	4.28	No	No	0	7	7
203	R:R:I350	R:R:S349	4.64	No	No	0	7	8
204	R:R:N351	R:R:P352	4.89	Yes	No	4	9	9
205	R:R:N351	R:R:Y355	10.47	Yes	No	0	9	9
206	R:R:I353	R:R:L357	5.71	No	No	0	8	6
207	R:R:N356	R:R:Y362	13.96	No	Yes	2	8	9
208	R:R:L357	R:R:Y362	3.52	No	Yes	0	6	9
209	R:R:K360	R:R:R363	9.9	No	No	0	4	9
210	R:R:I265	R:R:L266	2.85	No	Yes	0	4	7
211	R:R:I350	R:R:L354	2.85	No	Yes	0	7	8
212	L:L:?1	R:R:L98	2.84	Yes	No	0	0	6
213	R:R:Q295	R:R:T296	2.83	No	No	0	8	7
214	R:R:D68	R:R:M69	2.77	No	No	0	6	8
215	R:R:L86	R:R:L89	2.77	No	No	0	7	6
216	R:R:A157	R:R:R153	2.77	No	No	0	3	4
217	R:R:L301	R:R:L305	2.77	No	No	0	6	6
218	R:R:D326	R:R:M329	2.77	No	No	0	5	3
219	R:R:A170	R:R:Y116	2.67	No	Yes	0	8	6
220	R:R:F260	R:R:S264	2.64	No	No	0	7	6
221	R:R:R97	R:R:V105	2.62	Yes	No	1	6	5
222	R:R:R112	R:R:V177	2.62	No	No	0	8	6
223	R:R:F257	R:R:T253	2.59	No	No	0	5	6
224	R:R:S333	R:R:Y321	2.54	No	No	0	7	5
225	R:R:I322	R:R:R246	2.51	Yes	No	0	6	5
226	R:R:V297	R:R:W275	2.45	No	No	0	7	3
227	R:R:L75	R:R:R156	2.43	No	No	0	6	4
228	R:R:L269	R:R:R272	2.43	No	No	0	5	5
229	R:R:I322	R:R:W250	2.35	Yes	No	0	6	5
230	R:R:L269	R:R:Y137	2.34	No	Yes	0	5	7
231	R:R:R294	R:R:R298	2.13	No	No	0	7	6
232	R:R:G90	R:R:P92	2.03	No	No	0	7	9
233	R:R:A81	R:R:G78	1.95	No	No	0	9	7
234	R:R:A170	R:R:G120	1.95	No	No	0	8	5
235	R:R:G52	R:R:S349	1.86	No	No	0	8	8
236	R:R:G55	R:R:S54	1.86	No	No	0	9	5
237	R:R:G52	R:R:V51	1.84	No	No	0	8	5
238	R:R:G55	R:R:V58	1.84	No	No	0	9	6
239	R:R:G118	R:R:V117	1.84	No	No	0	7	6
240	R:R:G178	R:R:V177	1.84	No	No	0	5	6
241	R:R:G271	R:R:V297	1.84	No	No	0	6	7
242	R:R:G317	R:R:V316	1.84	No	Yes	0	6	6
243	R:R:A124	R:R:A166	1.79	No	No	0	8	8
244	R:R:P32	R:R:S31	1.78	No	No	0	3	7
245	R:R:P108	R:R:V179	1.77	No	No	0	3	6
246	R:R:G64	R:R:I63	1.76	No	No	0	4	8
247	R:R:G78	R:R:I63	1.76	No	No	0	7	8
248	R:R:G118	R:R:I87	1.76	No	No	0	7	7
249	R:R:G271	R:R:I270	1.76	No	No	0	6	8
250	R:R:C262	R:R:S133	1.72	No	Yes	0	6	9
251	R:R:G107	R:R:L110	1.71	No	No	0	9	6
252	R:R:A240	R:R:S238	1.71	No	No	0	6	5
253	R:R:V57	R:R:V58	1.6	No	No	0	5	6
254	R:R:V60	R:R:V82	1.6	No	No	0	7	7
255	R:R:V161	R:R:V165	1.6	No	No	0	4	5
256	R:R:V299	R:R:V303	1.6	No	No	0	8	8
257	R:R:T42	R:R:V39	1.59	Yes	No	0	6	8
258	R:R:P32	R:R:Q334	1.58	No	No	0	3	5
259	R:R:A366	R:R:L62	1.58	No	Yes	0	7	8
260	R:R:A306	R:R:L354	1.58	No	Yes	0	7	8
261	R:R:T71	R:R:T72	1.57	No	No	7	8	7
262	R:R:T72	R:R:T73	1.57	No	No	7	7	8
263	R:R:L35	R:R:V39	1.49	No	No	0	6	8
264	R:R:L113	R:R:V117	1.49	No	No	0	5	6
265	R:R:L176	R:R:V177	1.49	Yes	No	0	5	6
266	R:R:L354	R:R:V302	1.49	Yes	No	0	8	6
267	R:R:I319	R:R:I320	1.47	No	Yes	0	6	6
268	R:R:I319	R:R:I322	1.47	No	Yes	0	6	6
269	R:R:F33	R:R:P34	1.44	Yes	No	0	6	8
270	R:R:L46	R:R:L95	1.38	No	No	0	4	7
271	R:R:P103	R:R:W104	1.35	No	No	0	7	8
272	R:R:D326	R:R:E325	1.3	No	No	0	5	3
273	R:R:S359	R:R:Y362	1.27	No	Yes	0	9	9
274	R:R:S276	R:R:W275	1.24	No	No	0	3	3
275	R:R:F106	R:R:L110	1.22	No	No	0	7	6
276	R:R:R145	R:R:R147	1.07	No	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.72308	13	1	0
2	R:R:F33	6.118	5	1	6
3	R:R:T42	3.3875	4	6	6
4	R:R:L62	4.438	5	2	8
5	R:R:Y66	12.01	4	2	5
6	R:R:Y76	9.376	5	8	8
7	R:R:D84	4.55167	6	4	9
8	R:R:L91	6.45	4	0	8
9	R:R:R97	5.5775	4	1	6
10	R:R:Y116	7.255	4	0	6
11	R:R:E119	10.0225	4	1	6
12	R:R:Y123	5.97286	7	1	7
13	R:R:T125	4.19	4	4	9
14	R:R:H128	7.06	4	0	8
15	R:R:S133	4.0125	4	10	9
16	R:R:Y137	8.616	5	3	7
17	R:R:L176	3.56	4	0	5
18	R:R:L249	4.77	4	0	5
19	R:R:L266	6.31	4	0	7
20	R:R:Y267	9.095	4	10	8
21	R:R:W311	9.0675	4	0	8
22	R:R:V316	4.325	4	5	6
23	R:R:R318	8.594	5	1	7
24	R:R:I320	4.3475	4	5	6
25	R:R:I322	2.9975	4	0	6
26	R:R:F344	4.954	5	0	9
27	R:R:N351	7.222	5	4	9
28	R:R:L354	2.97	4	0	8
29	R:R:Y362	6.79	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L341	11.6962	10.42	Yes	No	0	0	6
2	R:R:L341	R:R:Y345	11.2582	5.86	No	No	0	6	8
3	R:R:L91	R:R:Y345	37.4047	12.89	Yes	No	0	8	8
4	R:R:C45	R:R:L91	24.5466	4.76	No	Yes	0	7	8
5	R:R:C45	R:R:L95	15.2025	7.94	No	No	0	7	7
6	R:R:L95	R:R:T42	11.436	2.95	No	Yes	0	7	6
7	L:L:?1	R:R:F344	34.3389	3.34	Yes	Yes	0	0	9
8	R:R:F344	R:R:Y345	28.192	8.25	Yes	No	0	9	8
9	L:L:?1	R:R:R318	52.6973	7.49	Yes	Yes	1	0	7
10	R:R:L249	R:R:R318	54.9078	4.86	Yes	Yes	0	5	7
11	R:R:L249	R:R:M248	54.3719	5.65	Yes	No	0	5	6
12	R:R:M248	R:R:P172	100	3.35	No	No	0	6	9
13	R:R:G171	R:R:P172	99.6007	4.06	No	No	0	5	9
14	R:R:G171	R:R:Y116	99.155	2.9	No	Yes	0	5	6
15	R:R:L167	R:R:Y116	97.3207	9.38	No	Yes	0	4	6
16	R:R:L167	R:R:W163	96.8492	3.42	No	No	0	4	9
17	R:R:H128	R:R:W163	95.404	4.23	Yes	No	0	8	9
18	R:R:H128	R:R:M80	72.3078	5.25	Yes	No	0	8	9
19	R:R:M80	R:R:N351	45.0587	8.41	No	Yes	0	9	9
20	R:R:N351	R:R:Y355	20.5534	10.47	Yes	No	0	9	9
21	R:R:V303	R:R:Y355	19.6182	7.57	No	No	0	8	9
22	R:R:M80	R:R:T125	26.7158	3.01	No	Yes	0	9	9
23	R:R:D84	R:R:T125	24.2683	4.34	Yes	Yes	4	9	9
24	R:R:D84	R:R:N56	47.009	4.04	Yes	No	0	9	9
25	R:R:A81	R:R:N56	43.5722	3.13	No	No	0	9	9
26	R:R:D84	R:R:N351	26.1567	6.73	Yes	Yes	4	9	9
27	R:R:A81	R:R:T59	33.463	3.36	No	No	0	9	9
28	R:R:T59	R:R:Y362	27.5994	9.99	No	Yes	2	9	9
29	R:R:L62	R:R:Y362	14.61	8.21	Yes	Yes	2	8	9
30	R:R:H128	R:R:S79	26.234	9.76	Yes	No	0	8	9
31	R:R:I159	R:R:S79	25.2808	3.1	No	No	0	8	9
32	R:R:I159	R:R:Y76	21.6328	6.04	No	Yes	8	8	8
33	R:R:L245	R:R:L249	15.3081	4.15	No	Yes	0	4	5
34	R:R:L176	R:R:L245	14.6306	4.15	Yes	No	0	5	4
35	R:R:L176	R:R:V177	12.567	1.49	Yes	No	0	5	6
36	R:R:F344	R:R:T122	45.1824	3.89	Yes	No	0	9	8
37	R:R:F344	R:R:W311	46.6869	3.01	Yes	Yes	0	9	8
38	R:R:L126	R:R:W311	41.8023	11.39	No	Yes	0	7	8
39	R:R:L126	R:R:P259	40.5683	3.28	No	No	0	7	9
40	R:R:P259	R:R:T130	38.0101	5.25	No	No	9	9	7
41	R:R:C262	R:R:T130	36.8353	5.07	No	No	0	6	7
42	R:R:C262	R:R:S133	35.5807	1.72	No	Yes	0	6	9
43	R:R:L266	R:R:S133	28.0657	3	Yes	Yes	0	7	9
44	R:R:L266	R:R:Y137	19.0025	16.41	Yes	Yes	0	7	7
45	R:R:C141	R:R:Y137	10.962	5.38	No	Yes	3	7	7
46	R:R:F314	R:R:R318	15.7358	16.03	No	Yes	0	6	7
47	R:R:F314	R:R:H315	15.0685	3.39	No	No	0	6	8
48	R:R:F256	R:R:H315	14.3961	15.84	No	No	0	8	8
49	R:R:V299	R:R:V303	10.0912	1.6	No	No	0	8	8
50	R:R:E119	R:R:F173	22.8308	18.66	Yes	No	1	6	5
51	R:R:F173	R:R:Y123	23.5083	7.22	No	Yes	1	5	7
52	R:R:E119	R:R:T122	22.6736	4.23	Yes	No	1	6	8
53	R:R:T122	R:R:Y123	23.2404	3.75	No	Yes	1	8	7
54	R:R:F173	R:R:M248	46.1846	7.46	No	No	0	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:F33	4.17	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:D94	10.22	1	Yes	No	0	7	0	1
L:L:?1	R:R:R97	12.48	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L115	5.69	1	Yes	No	0	5	0	1
L:L:?1	R:R:E234	5.44	1	Yes	No	0	4	0	1
L:L:?1	R:R:R236	6.65	1	Yes	No	0	5	0	1
L:L:?1	R:R:R318	7.49	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y321	16.05	1	Yes	No	0	5	0	1
L:L:?1	R:R:Q334	11.85	1	Yes	No	0	5	0	1
L:L:?1	R:R:N337	3.76	1	Yes	No	0	6	0	1
L:L:?1	R:R:L341	10.42	1	Yes	No	0	6	0	1
L:L:?1	R:R:F344	3.34	1	Yes	Yes	0	9	0	1
R:R:F33	R:R:Q334	7.03	1	Yes	No	6	5	1	1
R:R:F33	R:R:Y335	4.13	1	Yes	No	6	4	1	2
R:R:F33	R:R:I338	13.82	1	Yes	No	6	6	1	2
R:R:F344	R:R:I87	6.28	0	Yes	No	9	7	1	2
R:R:D94	R:R:R97	3.57	1	No	Yes	7	6	1	1
R:R:L115	R:R:R97	3.64	1	No	Yes	5	6	1	1
R:R:E234	R:R:S101	8.62	0	No	No	4	5	1	2
R:R:L115	R:R:S114	4.5	1	No	No	5	6	1	2
R:R:E119	R:R:T122	4.23	1	Yes	No	6	8	2	2
R:R:E119	R:R:Y123	6.73	1	Yes	Yes	6	7	2	2
R:R:E119	R:R:R318	10.47	1	Yes	Yes	6	7	2	1
R:R:T122	R:R:Y123	3.75	1	No	Yes	8	7	2	2
R:R:F344	R:R:T122	3.89	0	Yes	No	9	8	1	2
R:R:R318	R:R:Y123	4.12	1	Yes	Yes	7	7	1	2
R:R:L249	R:R:R318	4.86	0	Yes	Yes	5	7	2	1
R:R:F344	R:R:W311	3.01	0	Yes	Yes	9	8	1	2
R:R:F314	R:R:R318	16.03	0	No	Yes	6	7	2	1
R:R:N337	R:R:Y321	3.49	1	No	No	6	5	1	1
R:R:L341	R:R:Y345	5.86	0	No	No	6	8	1	2
R:R:F344	R:R:Y345	8.25	0	Yes	No	9	8	1	2
L:L:?1	R:R:L98	2.84	1	Yes	No	0	6	0	1
R:R:R97	R:R:V105	2.62	1	Yes	No	6	5	1	2
R:R:S333	R:R:Y321	2.54	0	No	No	7	5	2	1
R:R:P32	R:R:Q334	1.58	0	No	No	3	5	2	1
R:R:F33	R:R:P34	1.44	1	Yes	No	6	8	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8IBU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.9
Number of Linked Nodes	247
Number of Links	276
Number of Hubs	29
Number of Links mediated by Hubs	122
Number of Communities	10
Number of Nodes involved in Communities	55
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	55
Number Of Links MetaPath	54
Number of Shortest Paths	56944
Length Of Smallest Path	3
Average Path Length	18.3165
Length of Longest Path	36
Minimum Path Strength	1.465
Average Path Strength	5.64636
Maximum Path Strength	19.33
Minimum Path Correlation	0.7
Average Path Correlation	0.923923
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.44828
Average % Of Corr. Nodes	38.5121
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	34.89
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • hormone binding • peptide receptor activity • molecular transducer activity • G protein-coupled receptor activity • G protein-coupled peptide receptor activity • signaling receptor activity • transmembrane signaling receptor activity • tetrapyrrole binding • heme binding • electron transfer activity • cation binding • transition metal ion binding • iron ion binding • ion binding • metal ion binding • small molecule binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • electron transport chain • metabolic process • generation of precursor metabolites and energy • cellular anatomical structure • intracellular anatomical structure • cytoplasm • cytosol • cell periphery • plasma membrane • membrane • periplasmic space • protein binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ERY
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ERY
Name	Erythromycin
Synonyms	Erythromycin lactobionate
Identifier
Formula	C37 H67 N O13
Molecular Weight	733.927
SMILES
PubChem	12560
Formal Charge	0
Total Atoms	118
Total Chiral Atoms	18
Total Bonds	120
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43193
Sequence	>8IBU_nogp_Chain_R C S P F P L G A L V P V T A V C L C L F V V G V S G N V V T V M L I G R Y R D M R T T T N L Y L G S M A V S D L L I L L G L P F D L Y R L W R S R P W V F G P L L C R L S L Y V G E G C T Y A T L L H M T A L S V E R Y L A I C R P L R A R V L V T R R R V R A L I A V L W A V A L L S A G P F L F L V G V E Q E C R P S P A Q L G A L R V M L W V T T A Y F F L P F L C L S I L Y G L I G R E L W S G H R Q T V R V L L V V V L A F I I C W L P F H V G R I I Y I N T E D S R M M Y F S Q Y F N I V A L Q L F Y L S A S I N P I L Y N L I S K K Y R A A A F K L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IBU	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.51	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBU (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-		3.51	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBV	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.19	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBV (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-		3.19	2023-04-12	doi.org/10.1126/sciadv.ade9020
	9JMC	A	Peptide	Motilin	Motilin	Homo sapiens	DS-3801b	-	chim(Gs-CtGq)/β1/γ2	2.57	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMC (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	DS-3801b	-		2.57	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMD	A	Peptide	Motilin	Motilin	Homo sapiens	Azithromycin	-	chim(Gs-CtGq)/β1/γ2	2.74	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMD (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Azithromycin	-		2.74	2025-05-28	doi.org/10.1016/j.celrep.2025.115329

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.