Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 7.829231310
2R:R:F33 9.3475426
3R:R:N56 5.46409
4R:R:M69 5.8875408
5R:R:Y76 7.9225408
6R:R:L77 6.0875409
7R:R:M80 5.665449
8R:R:L91 5.2075408
9R:R:F106 9.916507
10R:R:E119 8.9625416
11R:R:Y123 7.17833617
12R:R:Y137 8.44507
13R:R:R142 4.644556
14R:R:W163 5.256509
15R:R:F173 7.115415
16R:R:P237 4.455405
17R:R:F260 4.93407
18R:R:L266 6.5575407
19R:R:W311 8.8125408
20R:R:R318 9.02667617
21R:R:Y335 10.4525424
22R:R:F344 6.976519
23R:R:Y345 5.3408
24R:R:Y362 5.49739
25R:R:L369 6.09505
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:P237 30.16843.69YesYes005
2R:R:P237 R:R:R236 17.39782.88YesNo055
3R:R:E234 R:R:R236 15.502617.45NoNo045
4R:R:E234 R:R:R102 13.59791.16NoNo046
5L:L:?1 R:R:D94 34.55515.08YesNo007
6R:R:D94 R:R:Y345 15.50754.6NoYes078
7R:R:L91 R:R:Y345 46.35884.69YesYes088
8R:R:C45 R:R:L91 37.43634.76NoYes078
9R:R:C45 R:R:L95 35.62294.76NoNo077
10R:R:L95 R:R:T42 33.79997.37NoNo076
11R:R:T42 R:R:W99 31.967312.13NoNo066
12R:R:L38 R:R:W99 22.659915.94NoNo066
13R:R:F33 R:R:L38 20.76963.65YesNo066
14L:L:?1 R:R:L341 10.817711.39YesNo006
15L:L:?1 R:R:F344 31.99137.29YesYes109
16R:R:F344 R:R:Y345 31.76057.22YesYes098
17L:L:?1 R:R:E119 28.17713.88YesYes106
18R:R:E119 R:R:Y123 33.25164.49YesYes167
19R:R:Y123 R:R:Y255 10015.89YesNo177
20R:R:L127 R:R:Y255 99.74518.21NoNo077
21R:R:L127 R:R:L162 97.6966.92NoNo078
22R:R:L158 R:R:L162 96.26746.92NoNo058
23R:R:L158 R:R:Y76 95.49784.69NoYes058
24R:R:L132 R:R:Y76 86.96498.21NoYes088
25R:R:L132 R:R:L77 86.12314.15NoYes089
26R:R:L77 R:R:Y355 59.41323.52YesNo099
27R:R:V303 R:R:Y355 19.09098.83NoNo089
28R:R:L354 R:R:V303 12.0252.98NoNo088
29L:L:?1 R:R:R318 37.62397.27YesYes107
30R:R:R318 R:R:Y123 33.34785.14YesYes177
31R:R:M129 R:R:Y355 43.22757.18NoNo079
32R:R:M129 R:R:N351 20.99095.61NoNo479
33R:R:D84 R:R:N351 20.66866.73NoNo099
34R:R:D84 R:R:N56 13.50175.39NoYes099
35R:R:L77 R:R:N356 36.200113.73YesNo098
36R:R:N356 R:R:Y362 28.124112.79NoYes389
37R:R:L62 R:R:Y362 11.85194.69NoYes089
38R:R:M129 R:R:M80 20.99095.78NoYes479
39R:R:H128 R:R:M80 19.25445.25NoYes089
40R:R:H128 R:R:W163 14.95435.29NoYes089
41R:R:F344 R:R:T122 34.28099.08YesNo198
42R:R:D94 R:R:R97 30.03378.34NoNo076
43R:R:R97 R:R:W104 24.622412NoNo068
44R:R:F106 R:R:W104 11.683521.05YesNo078
45R:R:C111 R:R:W104 11.71247.84NoNo098
46R:R:F344 R:R:W311 52.81875.01YesYes098
47R:R:F307 R:R:W311 49.08618.02NoYes098
48R:R:F307 R:R:L263 42.15494.87NoNo098
49R:R:L263 R:R:S133 41.2414.5NoNo089
50R:R:L266 R:R:S133 37.26316.01YesNo079
51R:R:L266 R:R:Y137 30.68314.07YesYes077
52R:R:I270 R:R:Y137 16.82063.63NoYes087
53R:R:F173 R:R:M248 10.87064.98YesNo056
54L:L:?1 R:R:L245 11.09199.32YesNo004
55R:R:F256 R:R:H315 20.21649.05NoNo088
56R:R:H315 R:R:R318 14.09339.03NoYes187
57R:R:F256 R:R:L312 12.23677.31NoNo086
58R:R:G271 R:R:I270 13.17461.76NoNo068
59R:R:G271 R:R:V297 11.93.68NoNo067
60L:L:?1 R:R:N337 26.565712.33YesNo006
61R:R:G317 R:R:N337 11.68355.09NoNo066
62R:R:N337 R:R:S333 13.59792.98NoNo067
63R:R:S333 R:R:T324 11.68353.2NoNo074
64R:R:T122 R:R:Y123 35.58444.99NoYes187
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D94 5.08 1 Yes No 0 7 0 1
L:L:?1 R:R:L115 5.18 1 Yes No 0 5 0 1
L:L:?1 R:R:E119 13.88 1 Yes Yes 0 6 0 1
L:L:?1 R:R:F173 4.56 1 Yes Yes 0 5 0 1
L:L:?1 R:R:P237 3.69 1 Yes Yes 0 5 0 1
L:L:?1 R:R:L245 9.32 1 Yes No 0 4 0 1
L:L:?1 R:R:F314 9.11 1 Yes No 0 6 0 1
L:L:?1 R:R:R318 7.27 1 Yes Yes 0 7 0 1
L:L:?1 R:R:Y321 11.4 1 Yes No 0 5 0 1
L:L:?1 R:R:N337 12.33 1 Yes No 0 6 0 1
L:L:?1 R:R:L341 11.39 1 Yes No 0 6 0 1
L:L:?1 R:R:F344 7.29 1 Yes Yes 0 9 0 1
R:R:I87 R:R:T122 4.56 1 No No 7 8 2 2
R:R:F344 R:R:I87 6.28 1 Yes No 9 7 1 2
R:R:D94 R:R:R97 8.34 0 No No 7 6 1 2
R:R:D94 R:R:Y345 4.6 0 No Yes 7 8 1 2
R:R:F173 R:R:L115 6.09 1 Yes No 5 5 1 1
R:R:L115 R:R:V177 8.94 1 No No 5 6 1 2
R:R:E119 R:R:Y123 4.49 1 Yes Yes 6 7 1 2
R:R:E119 R:R:F173 12.83 1 Yes Yes 6 5 1 1
R:R:E119 R:R:R318 4.65 1 Yes Yes 6 7 1 1
R:R:T122 R:R:Y123 4.99 1 No Yes 8 7 2 2
R:R:F344 R:R:T122 9.08 1 Yes No 9 8 1 2
R:R:T252 R:R:Y123 8.74 1 No Yes 7 7 2 2
R:R:R318 R:R:Y123 5.14 1 Yes Yes 7 7 1 2
R:R:F173 R:R:M248 4.98 1 Yes No 5 6 1 2
R:R:P237 R:R:Q241 6.32 0 Yes No 5 4 1 2
R:R:L242 R:R:P237 4.93 0 No Yes 3 5 2 1
R:R:L245 R:R:L249 9.69 0 No No 4 5 1 2
R:R:R318 R:R:T252 7.76 1 Yes No 7 7 1 2
R:R:F344 R:R:W311 5.01 1 Yes Yes 9 8 1 2
R:R:F314 R:R:H315 12.44 1 No No 6 8 1 2
R:R:F314 R:R:R318 20.31 1 No Yes 6 7 1 1
R:R:H315 R:R:R318 9.03 1 No Yes 8 7 2 1
R:R:G317 R:R:N337 5.09 0 No No 6 6 2 1
R:R:L341 R:R:Y345 4.69 0 No Yes 6 8 1 2
R:R:F344 R:R:Y345 7.22 1 Yes Yes 9 8 1 2
R:R:N337 R:R:S333 2.98 0 No No 6 7 1 2
R:R:P237 R:R:R236 2.88 0 Yes No 5 5 1 2
R:R:G118 R:R:V117 1.84 0 No No 7 6 1 2
L:L:?1 R:R:G118 1.28 1 Yes No 0 7 0 1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 9JMC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 3.63
Number of Linked Nodes 261
Number of Links 277
Number of Hubs 25
Number of Links mediated by Hubs 106
Number of Communities 6
Number of Nodes involved in Communities 29
Number of Links involved in Communities 38
Path Summary
Number Of Nodes in MetaPath 65
Number Of Links MetaPath 64
Number of Shortest Paths 44244
Length Of Smallest Path 3
Average Path Length 14.2263
Length of Longest Path 31
Minimum Path Strength 1.29
Average Path Strength 6.94341
Maximum Path Strength 16.525
Minimum Path Correlation 0.7
Average Path Correlation 0.926812
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 3.84615
Average % Of Corr. Nodes 48.0147
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 33.0543
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
Code_L_
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
Code_L_
Name
Synonyms
Identifier
Formula
Molecular Weight
SMILES
PubChem
Formal Charge
Total Atoms
Total Chiral Atoms
Total Bonds
Total Aromatic Bonds

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtO43193
Sequence
>9JMC_nogp_Chain_R
CSPFPLGAL VPVTAVCLC LFVVGVSGN VVTVMLIGR YRDMRTTTN 
LYLGSMAVS DLLILLGLP FDLYRLWRS RPWVFGPLL CRLSLYVGE 
GCTYATLLH MTALSVERY LAICRPLRA RVLVTRRRV RALIAVLWA 
VALLSAGPF LFLVGVEQD AAALFSREC RPSPAQLGA LRVMLWVTT 
AYFFLPFLC LSILYGLIG RELWSSERG HRQTVRVLL VVVLAFIIC 
WLPFHVGRI IYINTEDSR MMYFSQYFN IVALQLFYL SASINPILY 
NLISKKYRA AAFKLLL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8IBUAPeptideMotilinMotilinHomo sapiensErythromycin-A-chim(NtGi1-Gs-CtGq)/β1/γ23.512023-04-12doi.org/10.1126/sciadv.ade9020
8IBU (No Gprot) APeptideMotilinMotilinHomo sapiensErythromycin-A-3.512023-04-12doi.org/10.1126/sciadv.ade9020
8IBVAPeptideMotilinMotilinHomo sapiensMotilin-chim(NtGi1-Gs-CtGq)/β1/γ23.192023-04-12doi.org/10.1126/sciadv.ade9020
8IBV (No Gprot) APeptideMotilinMotilinHomo sapiensMotilin-3.192023-04-12doi.org/10.1126/sciadv.ade9020
9JMCAPeptideMotilinMotilinHomo sapiensDS-3801b-chim(Gs-CtGq)/β1/γ22.572025-05-28doi.org/10.1016/j.celrep.2025.115329
9JMC (No Gprot) APeptideMotilinMotilinHomo sapiensDS-3801b-2.572025-05-28doi.org/10.1016/j.celrep.2025.115329
9JMDAPeptideMotilinMotilinHomo sapiensAzithromycin-chim(Gs-CtGq)/β1/γ22.742025-05-28doi.org/10.1016/j.celrep.2025.115329
9JMD (No Gprot) APeptideMotilinMotilinHomo sapiensAzithromycin-2.742025-05-28doi.org/10.1016/j.celrep.2025.115329




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JMC_nogp.zip



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