psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	3.83	Yes	No	0	0	7
2	L:L:?1	R:R:L115	3.91	Yes	No	0	0	5
3	L:L:?1	R:R:E119	10.48	Yes	Yes	1	0	6
4	L:L:?1	R:R:L245	7.04	Yes	No	0	0	4
5	L:L:?1	R:R:F314	6.88	Yes	No	1	0	6
6	L:L:?1	R:R:R318	5.49	Yes	Yes	1	0	7
7	L:L:?1	R:R:Y321	8.61	Yes	No	0	0	5
8	L:L:?1	R:R:N337	9.31	Yes	No	0	0	6
9	L:L:?1	R:R:L341	8.6	Yes	No	0	0	6
10	L:L:?1	R:R:F344	5.5	Yes	Yes	1	0	9
11	R:R:C30	R:R:Q334	7.63	No	No	0	7	5
12	R:R:P32	R:R:S101	5.34	No	No	0	3	5
13	R:R:F33	R:R:L38	3.65	Yes	No	0	6	6
14	R:R:F33	R:R:Q334	14.05	Yes	No	2	6	5
15	R:R:F33	R:R:Y335	13.41	Yes	Yes	2	6	4
16	R:R:F33	R:R:I338	6.28	Yes	No	0	6	6
17	R:R:L35	R:R:V39	4.47	No	No	0	6	8
18	R:R:L38	R:R:W99	15.94	No	No	0	6	6
19	R:R:P40	R:R:V39	5.3	No	No	0	5	8
20	R:R:V39	R:R:W99	3.68	No	No	0	8	6
21	R:R:Q342	R:R:V41	7.16	No	No	0	6	7
22	R:R:L95	R:R:T42	7.37	No	No	0	7	6
23	R:R:T42	R:R:W99	12.13	No	No	0	6	6
24	R:R:C45	R:R:L91	4.76	No	Yes	0	7	8
25	R:R:C45	R:R:L95	4.76	No	No	0	7	7
26	R:R:L346	R:R:L48	4.15	No	No	0	7	6
27	R:R:L48	R:R:S349	6.01	No	No	0	6	8
28	R:R:F49	R:R:V53	6.55	No	No	0	6	7
29	R:R:F49	R:R:L91	9.74	No	Yes	0	6	8
30	R:R:G52	R:R:V51	3.68	No	No	0	8	5
31	R:R:G55	R:R:S54	3.71	No	No	0	9	5
32	R:R:A81	R:R:N56	4.69	No	Yes	0	9	9
33	R:R:D84	R:R:N56	5.39	No	Yes	0	9	9
34	R:R:L85	R:R:N56	6.87	No	Yes	0	7	9
35	R:R:N56	R:R:P352	4.89	Yes	No	0	9	9
36	R:R:L85	R:R:V57	4.47	No	No	0	7	5
37	R:R:V58	R:R:Y362	3.79	No	Yes	0	6	9
38	R:R:I63	R:R:T59	4.56	No	No	0	8	9
39	R:R:N356	R:R:T59	8.77	No	No	3	8	9
40	R:R:T59	R:R:Y362	7.49	No	Yes	3	9	9
41	R:R:L62	R:R:Y362	4.69	No	Yes	0	8	9
42	R:R:L369	R:R:L62	4.15	Yes	No	0	5	8
43	R:R:L369	R:R:R65	9.72	Yes	No	0	5	6
44	R:R:K368	R:R:Y66	10.75	No	No	0	6	5
45	R:R:L369	R:R:Y66	8.21	Yes	No	0	5	5
46	R:R:R67	R:R:R70	7.46	No	No	0	6	8
47	R:R:M69	R:R:N74	11.22	Yes	No	0	8	8
48	R:R:K361	R:R:M69	4.32	No	Yes	0	7	8
49	R:R:M69	R:R:Y362	4.79	Yes	Yes	0	8	9
50	R:R:N74	R:R:T71	4.39	No	No	0	8	8
51	R:R:R152	R:R:T72	3.88	No	No	0	5	7
52	R:R:T72	R:R:V155	7.93	No	No	0	7	7
53	R:R:L75	R:R:R152	4.86	No	No	0	6	5
54	R:R:L132	R:R:Y76	8.21	No	Yes	0	8	8
55	R:R:E135	R:R:Y76	11.22	No	Yes	0	8	8
56	R:R:V155	R:R:Y76	7.57	No	Yes	0	7	8
57	R:R:L158	R:R:Y76	4.69	No	Yes	0	5	8
58	R:R:L132	R:R:L77	4.15	No	Yes	0	8	9
59	R:R:L77	R:R:Y355	3.52	Yes	No	0	9	9
60	R:R:L77	R:R:N356	13.73	Yes	No	0	9	8
61	R:R:H128	R:R:S79	9.76	No	No	0	8	9
62	R:R:I159	R:R:S79	7.74	No	No	0	8	9
63	R:R:M80	R:R:T125	6.02	Yes	No	0	9	9
64	R:R:H128	R:R:M80	5.25	No	Yes	0	8	9
65	R:R:M129	R:R:M80	5.78	No	Yes	4	7	9
66	R:R:M80	R:R:N351	5.61	Yes	No	4	9	9
67	R:R:V82	R:R:W163	3.68	No	Yes	0	7	9
68	R:R:S83	R:R:W163	7.41	No	Yes	0	9	9
69	R:R:A348	R:R:D84	4.63	No	No	0	9	9
70	R:R:D84	R:R:N351	6.73	No	No	0	9	9
71	R:R:C121	R:R:L86	6.35	No	No	0	8	7
72	R:R:I87	R:R:T122	4.56	No	No	1	7	8
73	R:R:F344	R:R:I87	6.28	Yes	No	1	9	7
74	R:R:A348	R:R:L88	4.73	No	No	0	9	6
75	R:R:L91	R:R:Y345	4.69	Yes	Yes	0	8	8
76	R:R:F106	R:R:F93	10.72	Yes	No	0	7	6
77	R:R:F93	R:R:S114	5.28	No	No	0	6	6
78	R:R:D94	R:R:R97	8.34	No	No	0	7	6
79	R:R:D94	R:R:Y345	4.6	No	Yes	0	7	8
80	R:R:R100	R:R:Y96	14.4	No	No	0	5	5
81	R:R:F106	R:R:Y96	10.32	Yes	No	0	7	5
82	R:R:R97	R:R:W104	12	No	No	0	6	8
83	R:R:R97	R:R:S114	3.95	No	No	0	6	6
84	R:R:I338	R:R:L98	4.28	No	No	0	6	6
85	R:R:P103	R:R:S101	5.34	No	No	0	7	5
86	R:R:P103	R:R:R102	4.32	No	No	0	7	6
87	R:R:R102	R:R:R233	9.6	No	No	0	6	4
88	R:R:F106	R:R:W104	21.05	Yes	No	0	7	8
89	R:R:C111	R:R:W104	7.84	No	No	0	9	8
90	R:R:F106	R:R:L110	4.87	Yes	No	0	7	6
91	R:R:G107	R:R:P108	4.06	No	No	0	9	3
92	R:R:L109	R:R:P108	4.93	No	No	0	3	3
93	R:R:E180	R:R:P108	7.86	No	No	0	4	3
94	R:R:C111	R:R:C235	7.28	No	No	0	9	9
95	R:R:R112	R:R:V177	5.23	No	No	0	8	6
96	R:R:F173	R:R:L115	6.09	No	No	0	5	5
97	R:R:L115	R:R:V177	8.94	No	No	0	5	6
98	R:R:L167	R:R:Y116	5.86	No	No	0	4	6
99	R:R:A170	R:R:Y116	4	No	No	0	8	6
100	R:R:L174	R:R:Y116	7.03	No	No	0	5	6
101	R:R:E119	R:R:Y123	4.49	Yes	Yes	1	6	7
102	R:R:E119	R:R:F173	12.83	Yes	No	0	6	5
103	R:R:E119	R:R:R318	4.65	Yes	Yes	1	6	7
104	R:R:T122	R:R:Y123	4.99	No	Yes	1	8	7
105	R:R:F344	R:R:T122	9.08	Yes	No	1	9	8
106	R:R:S169	R:R:Y123	3.82	No	Yes	1	6	7
107	R:R:T252	R:R:Y123	8.74	No	Yes	1	7	7
108	R:R:Y123	R:R:Y255	15.89	Yes	No	1	7	7
109	R:R:R318	R:R:Y123	5.14	Yes	Yes	1	7	7
110	R:R:A124	R:R:W163	6.48	No	Yes	0	8	9
111	R:R:L126	R:R:W311	14.81	No	Yes	0	7	8
112	R:R:L127	R:R:L162	6.92	No	No	0	7	8
113	R:R:L127	R:R:Y255	8.21	No	No	0	7	7
114	R:R:H128	R:R:W163	5.29	No	Yes	0	8	9
115	R:R:M129	R:R:N351	5.61	No	No	4	7	9
116	R:R:M129	R:R:Y355	7.18	No	No	0	7	9
117	R:R:P259	R:R:T130	5.25	No	No	0	9	7
118	R:R:C262	R:R:T130	5.07	No	No	0	6	7
119	R:R:L263	R:R:S133	4.5	No	No	5	8	9
120	R:R:L266	R:R:S133	6.01	Yes	No	0	7	9
121	R:R:S133	R:R:Y267	10.17	No	Yes	5	9	8
122	R:R:R136	R:R:Y267	7.2	No	Yes	0	9	8
123	R:R:C141	R:R:Y137	8.06	No	Yes	0	7	7
124	R:R:R142	R:R:Y137	8.23	Yes	Yes	0	6	7
125	R:R:L266	R:R:Y137	14.07	Yes	Yes	0	7	7
126	R:R:L269	R:R:Y137	8.21	No	Yes	0	5	7
127	R:R:I270	R:R:Y137	3.63	No	Yes	0	8	7
128	R:R:L138	R:R:R142	3.64	No	Yes	0	5	6
129	R:R:I140	R:R:I270	5.89	No	No	0	8	8
130	R:R:R142	R:R:R145	8.53	Yes	No	6	6	6
131	R:R:L144	R:R:R147	3.64	No	No	0	6	6
132	R:R:R154	R:R:V150	13.08	No	No	0	6	6
133	R:R:L158	R:R:L162	6.92	No	No	0	5	8
134	R:R:S169	R:R:Y255	8.9	No	No	1	6	7
135	R:R:G171	R:R:P172	4.06	No	No	0	5	9
136	R:R:M248	R:R:P172	10.06	No	No	0	6	9
137	R:R:F173	R:R:M248	4.98	No	No	0	5	6
138	R:R:F175	R:R:L176	6.09	No	No	0	5	5
139	R:R:G178	R:R:V177	3.68	No	No	0	5	6
140	R:R:C235	R:R:E180	7.6	No	No	0	9	4
141	R:R:D182	R:R:R233	14.29	No	No	0	4	4
142	R:R:F231	R:R:L230	4.87	No	No	0	4	2
143	R:R:E234	R:R:R236	17.45	No	No	0	4	5
144	R:R:P237	R:R:Q241	6.32	Yes	No	0	5	4
145	R:R:L242	R:R:P237	4.93	No	Yes	0	3	5
146	R:R:P239	R:R:S238	5.34	No	No	0	7	5
147	R:R:Q241	R:R:S238	7.22	No	No	0	4	5
148	R:R:L245	R:R:L249	9.69	No	No	0	4	5
149	R:R:R246	R:R:W250	6	No	No	0	5	5
150	R:R:I322	R:R:R246	6.26	No	No	7	6	5
151	R:R:N323	R:R:R246	10.85	No	No	7	5	5
152	R:R:I322	R:R:L249	5.71	No	No	0	6	5
153	R:R:T253	R:R:W250	10.92	No	No	0	6	5
154	R:R:I319	R:R:W250	14.09	No	No	0	6	5
155	R:R:R318	R:R:T252	7.76	Yes	No	1	7	7
156	R:R:F257	R:R:T253	3.89	No	No	0	5	6
157	R:R:F256	R:R:F257	8.57	No	No	0	8	5
158	R:R:F256	R:R:L312	7.31	No	No	0	8	6
159	R:R:F256	R:R:H315	9.05	No	No	0	8	8
160	R:R:L258	R:R:P259	6.57	No	No	0	5	9
161	R:R:F260	R:R:S264	7.93	Yes	No	0	7	6
162	R:R:F260	R:R:F307	4.29	Yes	No	0	7	9
163	R:R:F260	R:R:I308	6.28	Yes	No	0	7	7
164	R:R:L263	R:R:Y267	3.52	No	Yes	5	8	8
165	R:R:F307	R:R:L263	4.87	No	No	0	9	8
166	R:R:L300	R:R:Y267	7.03	No	Yes	0	9	8
167	R:R:G271	R:R:V297	3.68	No	No	0	6	7
168	R:R:E273	R:R:R272	4.65	No	No	0	5	5
169	R:R:L274	R:R:T296	4.42	No	No	0	8	7
170	R:R:E290	R:R:W275	7.63	No	No	0	5	3
171	R:R:V297	R:R:W275	8.58	No	No	0	7	3
172	R:R:E290	R:R:R294	19.77	No	No	0	5	7
173	R:R:Q295	R:R:R298	17.52	No	No	0	8	6
174	R:R:I358	R:R:V299	10.75	No	No	0	7	8
175	R:R:V303	R:R:Y355	8.83	No	No	0	8	9
176	R:R:F307	R:R:W311	8.02	No	Yes	0	9	8
177	R:R:C310	R:R:S347	6.89	No	No	0	9	9
178	R:R:F344	R:R:W311	5.01	Yes	Yes	0	9	8
179	R:R:S347	R:R:W311	7.41	No	Yes	0	9	8
180	R:R:L343	R:R:P313	4.93	No	No	0	8	9
181	R:R:F314	R:R:H315	12.44	No	No	1	6	8
182	R:R:F314	R:R:R318	20.31	No	Yes	1	6	7
183	R:R:H315	R:R:R318	9.03	No	Yes	1	8	7
184	R:R:G317	R:R:V316	3.68	No	No	0	6	6
185	R:R:F336	R:R:V316	6.55	No	No	0	5	6
186	R:R:G317	R:R:I320	5.29	No	No	0	6	6
187	R:R:G317	R:R:N337	5.09	No	No	0	6	6
188	R:R:F332	R:R:I320	8.79	No	No	0	4	6
189	R:R:F336	R:R:I320	3.77	No	No	0	5	6
190	R:R:I322	R:R:N323	4.25	No	No	7	6	5
191	R:R:D326	R:R:S327	4.42	No	No	0	5	5
192	R:R:D326	R:R:M329	4.16	No	No	0	5	3
193	R:R:M329	R:R:R328	7.44	No	No	0	3	4
194	R:R:Y331	R:R:Y335	18.86	No	Yes	0	3	4
195	R:R:Q334	R:R:Y335	6.76	No	Yes	2	5	4
196	R:R:I338	R:R:Q342	4.12	No	No	0	6	6
197	R:R:L341	R:R:Y345	4.69	No	Yes	0	6	8
198	R:R:F344	R:R:Y345	7.22	Yes	Yes	0	9	8
199	R:R:I350	R:R:L346	7.14	No	No	0	7	7
200	R:R:I350	R:R:L354	7.14	No	No	0	7	8
201	R:R:I353	R:R:L357	5.71	No	No	0	8	6
202	R:R:N356	R:R:Y362	12.79	No	Yes	3	8	9
203	R:R:K360	R:R:R363	9.9	No	No	0	4	9
204	R:R:F367	R:R:L371	6.09	No	No	0	4	2
205	R:R:L369	R:R:L370	5.54	Yes	No	0	5	7
206	R:R:E135	R:R:R154	3.49	No	No	0	8	6
207	R:R:G52	R:R:L88	3.42	No	No	0	8	6
208	R:R:L167	R:R:W163	3.42	No	Yes	0	4	9
209	R:R:L176	R:R:P172	3.28	No	No	0	5	9
210	R:R:L245	R:R:P237	3.28	No	Yes	0	4	5
211	R:R:L312	R:R:P313	3.28	No	No	0	6	9
212	R:R:C121	R:R:I87	3.27	No	No	0	8	7
213	R:R:A365	R:R:M69	3.22	No	Yes	0	7	8
214	R:R:S333	R:R:T324	3.2	No	No	0	7	4
215	R:R:C262	R:R:L266	3.17	No	Yes	0	6	7
216	R:R:A366	R:R:L62	3.15	No	No	0	7	8
217	R:R:A244	R:R:L176	3.15	No	No	0	5	5
218	R:R:C141	R:R:E273	3.04	No	No	0	7	5
219	R:R:M248	R:R:V251	3.04	No	No	0	6	6
220	R:R:M330	R:R:T324	3.01	No	No	0	4	4
221	R:R:L48	R:R:V44	2.98	No	No	0	6	5
222	R:R:L127	R:R:V165	2.98	No	No	0	7	5
223	R:R:L266	R:R:V134	2.98	Yes	No	0	7	7
224	R:R:L138	R:R:V148	2.98	No	No	0	5	6
225	R:R:L274	R:R:V297	2.98	No	No	0	8	7
226	R:R:L354	R:R:V303	2.98	No	No	0	8	8
227	R:R:N337	R:R:S333	2.98	No	No	0	6	7
228	R:R:L77	R:R:T73	2.95	Yes	No	0	9	8
229	R:R:P237	R:R:R236	2.88	Yes	No	0	5	5
230	R:R:Q342	R:R:V339	2.87	No	No	0	6	6
231	R:R:I265	R:R:L261	2.85	No	No	0	4	4
232	R:R:L369	R:R:M61	2.83	Yes	No	0	5	4
233	R:R:P34	R:R:Y335	2.78	No	Yes	0	8	4
234	R:R:F106	R:R:V105	2.62	Yes	No	0	7	5
235	R:R:H293	R:R:L274	2.57	No	No	0	7	8
236	R:R:S359	R:R:Y362	2.54	No	Yes	0	9	9
237	R:R:L357	R:R:R363	2.43	No	No	0	6	9
238	R:R:L357	R:R:Y362	2.34	No	Yes	0	6	9
239	R:R:R153	R:R:R156	2.13	No	No	0	4	4
240	R:R:G55	R:R:P352	2.03	No	No	0	9	9
241	R:R:G90	R:R:P92	2.03	No	No	0	7	9
242	R:R:A81	R:R:G78	1.95	No	No	0	9	7
243	R:R:A170	R:R:G120	1.95	No	No	0	8	5
244	R:R:A340	R:R:P313	1.87	No	No	0	7	9
245	R:R:G118	R:R:V117	1.84	No	No	0	7	6
246	R:R:A124	R:R:A166	1.79	No	No	0	8	8
247	R:R:P32	R:R:S31	1.78	No	No	0	3	7
248	R:R:G271	R:R:I270	1.76	No	No	0	6	8
249	R:R:G36	R:R:L35	1.71	No	No	0	6	6
250	R:R:G243	R:R:L242	1.71	No	No	0	1	3
251	R:R:A81	R:R:V60	1.7	No	No	0	9	7
252	R:R:L91	R:R:P92	1.64	Yes	No	0	8	9
253	R:R:A139	R:R:I140	1.62	No	No	0	8	8
254	R:R:S238	R:R:V179	1.62	No	No	0	5	6
255	R:R:S264	R:R:V304	1.62	No	No	0	6	8
256	R:R:A306	R:R:I350	1.62	No	No	0	7	7
257	R:R:V161	R:R:V165	1.6	No	No	0	4	5
258	R:R:V299	R:R:V303	1.6	No	No	0	8	8
259	R:R:G292	R:R:H293	1.59	No	No	0	6	7
260	R:R:A131	R:R:L162	1.58	No	No	0	8	8
261	R:R:M330	R:R:S327	1.53	No	No	0	4	5
262	R:R:G64	R:R:R70	1.5	No	No	0	4	8
263	R:R:L354	R:R:V302	1.49	No	No	0	8	6
264	R:R:P143	R:R:R142	1.44	No	Yes	6	8	6
265	R:R:P143	R:R:R145	1.44	No	No	6	8	6
266	R:R:E273	R:R:S276	1.44	No	No	0	5	3
267	R:R:Q295	R:R:V299	1.43	No	No	0	8	8
268	R:R:I309	R:R:L343	1.43	No	No	0	6	8
269	R:R:H293	R:R:S277	1.39	No	No	0	7	6
270	R:R:L110	R:R:L113	1.38	No	No	0	6	5
271	R:R:A146	R:R:R142	1.38	No	Yes	0	7	6
272	R:R:R153	R:R:T151	1.29	No	No	0	4	8
273	R:R:R154	R:R:T151	1.29	No	No	0	6	8
274	R:R:I63	R:R:R70	1.25	No	No	0	8	8
275	R:R:F260	R:R:L261	1.22	Yes	No	0	7	4
276	R:R:E234	R:R:R102	1.16	No	No	0	4	6
277	L:L:?1	R:R:G118	0.97	Yes	No	0	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.42	11	1	0
2	R:R:F33	9.3475	4	2	6
3	R:R:N56	5.46	4	0	9
4	R:R:M69	5.8875	4	0	8
5	R:R:Y76	7.9225	4	0	8
6	R:R:L77	6.0875	4	0	9
7	R:R:M80	5.665	4	4	9
8	R:R:L91	5.2075	4	0	8
9	R:R:F106	9.916	5	0	7
10	R:R:E119	8.1125	4	1	6
11	R:R:Y123	7.17833	6	1	7
12	R:R:Y137	8.44	5	0	7
13	R:R:R142	4.644	5	6	6
14	R:R:W163	5.256	5	0	9
15	R:R:P237	4.3525	4	0	5
16	R:R:F260	4.93	4	0	7
17	R:R:L266	6.5575	4	0	7
18	R:R:Y267	6.98	4	5	8
19	R:R:W311	8.8125	4	0	8
20	R:R:R318	8.73	6	1	7
21	R:R:Y335	10.4525	4	2	4
22	R:R:F344	6.618	5	1	9
23	R:R:Y345	5.3	4	0	8
24	R:R:Y362	5.49	7	3	9
25	R:R:L369	6.09	5	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L245	40.9331	7.04	Yes	No	0	0	4
2	R:R:L245	R:R:P237	30.7167	3.28	No	Yes	0	4	5
3	R:R:P237	R:R:R236	17.7008	2.88	Yes	No	0	5	5
4	R:R:E234	R:R:R236	15.772	17.45	No	No	0	4	5
5	R:R:E234	R:R:R102	13.8336	1.16	No	No	0	4	6
6	L:L:?1	R:R:D94	36.2145	3.83	Yes	No	0	0	7
7	R:R:D94	R:R:Y345	16.5127	4.6	No	Yes	0	7	8
8	R:R:L91	R:R:Y345	49.2448	4.69	Yes	Yes	0	8	8
9	R:R:C45	R:R:L91	39.7451	4.76	No	Yes	0	7	8
10	R:R:C45	R:R:L95	37.8163	4.76	No	No	0	7	7
11	R:R:L95	R:R:T42	35.8778	7.37	No	No	0	7	6
12	R:R:T42	R:R:W99	33.9298	12.13	No	No	0	6	6
13	R:R:L38	R:R:W99	24.0452	15.94	No	No	0	6	6
14	R:R:F33	R:R:L38	22.0394	3.65	Yes	No	0	6	6
15	L:L:?1	R:R:L341	11.8567	8.6	Yes	No	0	0	6
16	R:R:L341	R:R:Y345	10.7456	4.69	No	Yes	0	6	8
17	L:L:?1	R:R:F344	34.9206	5.5	Yes	Yes	1	0	9
18	R:R:F344	R:R:Y345	32.7609	7.22	Yes	Yes	0	9	8
19	R:R:F33	R:R:I338	10.2886	6.28	Yes	No	0	6	6
20	L:L:?1	R:R:E119	35.3295	10.48	Yes	Yes	1	0	6
21	R:R:E119	R:R:Y123	33.367	4.49	Yes	Yes	1	6	7
22	R:R:Y123	R:R:Y255	100	15.89	Yes	No	1	7	7
23	R:R:L127	R:R:Y255	99.7451	8.21	No	No	0	7	7
24	R:R:L127	R:R:L162	97.696	6.92	No	No	0	7	8
25	R:R:L158	R:R:L162	96.2674	6.92	No	No	0	5	8
26	R:R:L158	R:R:Y76	95.4978	4.69	No	Yes	0	5	8
27	R:R:L132	R:R:Y76	86.9649	8.21	No	Yes	0	8	8
28	R:R:L132	R:R:L77	86.1231	4.15	No	Yes	0	8	9
29	R:R:L77	R:R:Y355	59.4132	3.52	Yes	No	0	9	9
30	R:R:V303	R:R:Y355	19.0909	8.83	No	No	0	8	9
31	R:R:L354	R:R:V303	12.025	2.98	No	No	0	8	8
32	L:L:?1	R:R:R318	37.1236	5.49	Yes	Yes	1	0	7
33	R:R:R318	R:R:Y123	33.3478	5.14	Yes	Yes	1	7	7
34	R:R:M129	R:R:Y355	43.2275	7.18	No	No	0	7	9
35	R:R:M129	R:R:N351	20.9909	5.61	No	No	4	7	9
36	R:R:D84	R:R:N351	20.6686	6.73	No	No	0	9	9
37	R:R:D84	R:R:N56	13.5017	5.39	No	Yes	0	9	9
38	R:R:L77	R:R:N356	36.2001	13.73	Yes	No	0	9	8
39	R:R:N356	R:R:Y362	28.1241	12.79	No	Yes	3	8	9
40	R:R:L62	R:R:Y362	11.8519	4.69	No	Yes	0	8	9
41	R:R:M129	R:R:M80	20.9909	5.78	No	Yes	4	7	9
42	R:R:H128	R:R:M80	19.2544	5.25	No	Yes	0	8	9
43	R:R:H128	R:R:W163	14.9543	5.29	No	Yes	0	8	9
44	R:R:F344	R:R:T122	34.2424	9.08	Yes	No	1	9	8
45	R:R:D94	R:R:R97	30.6494	8.34	No	No	0	7	6
46	R:R:R97	R:R:W104	25.1227	12	No	No	0	6	8
47	R:R:F106	R:R:W104	11.9144	21.05	Yes	No	0	7	8
48	R:R:C111	R:R:W104	11.9432	7.84	No	No	0	9	8
49	L:L:?1	R:R:L115	14.5599	3.91	Yes	No	0	0	5
50	R:R:F344	R:R:W311	54.6272	5.01	Yes	Yes	0	9	8
51	R:R:F307	R:R:W311	50.7407	8.02	No	Yes	0	9	8
52	R:R:F307	R:R:L263	43.5402	4.87	No	No	0	9	8
53	R:R:L263	R:R:S133	39.1101	4.5	No	No	5	8	9
54	R:R:L266	R:R:S133	38.456	6.01	Yes	No	0	7	9
55	R:R:L266	R:R:Y137	31.645	14.07	Yes	Yes	0	7	7
56	R:R:I270	R:R:Y137	17.3208	3.63	No	Yes	0	8	7
57	R:R:F173	R:R:M248	16.7292	4.98	No	No	0	5	6
58	R:R:M248	R:R:P172	11.9962	10.06	No	No	0	6	9
59	R:R:E119	R:R:F173	13.3237	12.83	Yes	No	0	6	5
60	R:R:F256	R:R:H315	19.5238	9.05	No	No	0	8	8
61	R:R:H315	R:R:R318	13.747	9.03	No	Yes	1	8	7
62	R:R:F256	R:R:L312	11.8519	7.31	No	No	0	8	6
63	R:R:G271	R:R:I270	13.5594	1.76	No	No	0	6	8
64	R:R:G271	R:R:V297	12.2463	3.68	No	No	0	6	7
65	L:L:?1	R:R:N337	27.1044	9.31	Yes	No	0	0	6
66	R:R:G317	R:R:N337	11.9144	5.09	No	No	0	6	6
67	R:R:N337	R:R:S333	13.8672	2.98	No	No	0	6	7
68	R:R:S333	R:R:T324	11.9144	3.2	No	No	0	7	4
69	R:R:T122	R:R:Y123	35.6999	4.99	No	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	3.83	1	Yes	No	0	7	0	1
L:L:?1	R:R:L115	3.91	1	Yes	No	0	5	0	1
L:L:?1	R:R:E119	10.48	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:L245	7.04	1	Yes	No	0	4	0	1
L:L:?1	R:R:F314	6.88	1	Yes	No	0	6	0	1
L:L:?1	R:R:R318	5.49	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:Y321	8.61	1	Yes	No	0	5	0	1
L:L:?1	R:R:N337	9.31	1	Yes	No	0	6	0	1
L:L:?1	R:R:L341	8.6	1	Yes	No	0	6	0	1
L:L:?1	R:R:F344	5.5	1	Yes	Yes	0	9	0	1
R:R:I87	R:R:T122	4.56	1	No	No	7	8	2	2
R:R:F344	R:R:I87	6.28	1	Yes	No	9	7	1	2
R:R:D94	R:R:R97	8.34	0	No	No	7	6	1	2
R:R:D94	R:R:Y345	4.6	0	No	Yes	7	8	1	2
R:R:F173	R:R:L115	6.09	0	No	No	5	5	2	1
R:R:L115	R:R:V177	8.94	0	No	No	5	6	1	2
R:R:E119	R:R:Y123	4.49	1	Yes	Yes	6	7	1	2
R:R:E119	R:R:F173	12.83	1	Yes	No	6	5	1	2
R:R:E119	R:R:R318	4.65	1	Yes	Yes	6	7	1	1
R:R:T122	R:R:Y123	4.99	1	No	Yes	8	7	2	2
R:R:F344	R:R:T122	9.08	1	Yes	No	9	8	1	2
R:R:T252	R:R:Y123	8.74	1	No	Yes	7	7	2	2
R:R:R318	R:R:Y123	5.14	1	Yes	Yes	7	7	1	2
R:R:L245	R:R:L249	9.69	0	No	No	4	5	1	2
R:R:R318	R:R:T252	7.76	1	Yes	No	7	7	1	2
R:R:F344	R:R:W311	5.01	1	Yes	Yes	9	8	1	2
R:R:F314	R:R:H315	12.44	1	No	No	6	8	1	2
R:R:F314	R:R:R318	20.31	1	No	Yes	6	7	1	1
R:R:H315	R:R:R318	9.03	1	No	Yes	8	7	2	1
R:R:G317	R:R:N337	5.09	0	No	No	6	6	2	1
R:R:L341	R:R:Y345	4.69	0	No	Yes	6	8	1	2
R:R:F344	R:R:Y345	7.22	1	Yes	Yes	9	8	1	2
R:R:L245	R:R:P237	3.28	0	No	Yes	4	5	1	2
R:R:N337	R:R:S333	2.98	0	No	No	6	7	1	2
R:R:G118	R:R:V117	1.84	0	No	No	7	6	1	2
L:L:?1	R:R:G118	0.97	1	Yes	No	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JMC_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	261
Number of Links	277
Number of Hubs	25
Number of Links mediated by Hubs	107
Number of Communities	7
Number of Nodes involved in Communities	30
Number of Links involved in Communities	37

Path Summary
Number Of Nodes in MetaPath	70
Number Of Links MetaPath	69
Number of Shortest Paths	45625
Length Of Smallest Path	3
Average Path Length	14.3166
Length of Longest Path	31
Minimum Path Strength	1.29
Average Path Strength	6.77523
Maximum Path Strength	16.525
Minimum Path Correlation	0.7
Average Path Correlation	0.927547
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	47.9146
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.2666
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	A1L
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	A1L
Name	[2-[[(2S)-1-[bis(phenylmethyl)amino]-5-[[N-(methylcarbamoyl)carbamimidoyl]amino]-1-oxidanylidene-pentan-2-yl]amino]-2-oxidanylidene-ethyl]-diazonio-azanide
Synonyms
Identifier
Formula	C24 H31 N9 O3
Molecular Weight	493.561
SMILES
PubChem	44129754
Formal Charge	0
Total Atoms	67
Total Chiral Atoms	1
Total Bonds	68
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43193
Sequence	>9JMC_nogp_Chain_R C S P F P L G A L V P V T A V C L C L F V V G V S G N V V T V M L I G R Y R D M R T T T N L Y L G S M A V S D L L I L L G L P F D L Y R L W R S R P W V F G P L L C R L S L Y V G E G C T Y A T L L H M T A L S V E R Y L A I C R P L R A R V L V T R R R V R A L I A V L W A V A L L S A G P F L F L V G V E Q D A A A L F S R E C R P S P A Q L G A L R V M L W V T T A Y F F L P F L C L S I L Y G L I G R E L W S S E R G H R Q T V R V L L V V V L A F I I C W L P F H V G R I I Y I N T E D S R M M Y F S Q Y F N I V A L Q L F Y L S A S I N P I L Y N L I S K K Y R A A A F K L L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IBU	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.51	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBU (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-		3.51	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBV	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.19	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBV (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-		3.19	2023-04-12	doi.org/10.1126/sciadv.ade9020
	9JMC	A	Peptide	Motilin	Motilin	Homo sapiens	DS-3801b	-	chim(Gs-CtGq)/β1/γ2	2.57	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMC (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	DS-3801b	-		2.57	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMD	A	Peptide	Motilin	Motilin	Homo sapiens	Azithromycin	-	chim(Gs-CtGq)/β1/γ2	2.74	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMD (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Azithromycin	-		2.74	2025-05-28	doi.org/10.1016/j.celrep.2025.115329

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JMC_nogp.zip

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