psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D94	6.96	Yes	Yes	1	0	7
2	L:L:?1	R:R:R97	6.23	Yes	No	1	0	6
3	L:L:?1	R:R:L98	5.32	Yes	No	0	0	6
4	L:L:?1	R:R:L115	7.1	Yes	No	0	0	5
5	L:L:?1	R:R:E234	11.89	Yes	Yes	1	0	4
6	L:L:?1	R:R:F314	5.46	Yes	Yes	1	0	6
7	L:L:?1	R:R:Y321	6.76	Yes	No	0	0	5
8	L:L:?1	R:R:L341	8.87	Yes	No	1	0	6
9	R:R:F33	R:R:S31	5.28	No	No	0	6	7
10	R:R:L38	R:R:S31	4.5	No	No	0	6	7
11	R:R:P32	R:R:Q334	4.74	No	No	0	3	5
12	R:R:F33	R:R:Y335	12.38	No	No	0	6	4
13	R:R:F33	R:R:I338	6.28	No	No	0	6	6
14	R:R:A37	R:R:P34	5.61	No	No	0	5	8
15	R:R:P34	R:R:Y335	4.17	No	No	0	8	4
16	R:R:L38	R:R:W99	4.56	No	No	0	6	6
17	R:R:I338	R:R:V41	7.68	No	No	0	6	7
18	R:R:Q342	R:R:V41	5.73	No	No	0	6	7
19	R:R:L95	R:R:T42	5.9	No	No	0	7	6
20	R:R:T42	R:R:W99	13.34	No	No	0	6	6
21	R:R:C45	R:R:L95	6.35	No	No	0	7	7
22	R:R:F49	R:R:V53	10.49	No	No	0	6	7
23	R:R:F49	R:R:L91	7.31	No	No	0	6	8
24	R:R:F49	R:R:P92	4.33	No	No	0	6	9
25	R:R:D84	R:R:N56	9.42	No	Yes	0	9	9
26	R:R:L85	R:R:N56	6.87	No	Yes	0	7	9
27	R:R:N56	R:R:P352	11.4	Yes	No	0	9	9
28	R:R:N356	R:R:T59	7.31	No	No	4	8	9
29	R:R:T59	R:R:Y362	9.99	No	Yes	4	9	9
30	R:R:L369	R:R:M61	4.24	No	No	0	5	4
31	R:R:L62	R:R:Y362	5.86	No	Yes	0	8	9
32	R:R:L369	R:R:L62	5.54	No	No	0	5	8
33	R:R:I63	R:R:N74	4.25	No	No	0	8	8
34	R:R:G64	R:R:R70	4.5	No	No	0	4	8
35	R:R:R65	R:R:Y66	17.49	No	No	0	6	5
36	R:R:K368	R:R:Y66	10.75	No	No	0	6	5
37	R:R:R67	R:R:R70	13.86	No	No	0	6	8
38	R:R:A365	R:R:M69	4.83	No	No	0	7	8
39	R:R:N74	R:R:T71	4.39	No	No	0	8	8
40	R:R:E135	R:R:T72	4.23	No	No	0	8	7
41	R:R:T72	R:R:V150	4.76	No	No	0	7	6
42	R:R:T72	R:R:V155	6.35	No	No	0	7	7
43	R:R:L75	R:R:R152	10.93	No	No	0	6	5
44	R:R:L75	R:R:V155	5.96	No	No	0	6	7
45	R:R:L132	R:R:Y76	4.69	No	Yes	0	8	8
46	R:R:E135	R:R:Y76	5.61	No	Yes	0	8	8
47	R:R:V155	R:R:Y76	6.31	No	Yes	0	7	8
48	R:R:I159	R:R:Y76	9.67	No	Yes	0	8	8
49	R:R:L77	R:R:Y355	4.69	No	Yes	0	9	9
50	R:R:L77	R:R:N356	10.98	No	No	0	9	8
51	R:R:I159	R:R:S79	7.74	No	No	0	8	9
52	R:R:S79	R:R:W163	4.94	No	Yes	0	9	9
53	R:R:M129	R:R:M80	4.33	No	No	3	7	9
54	R:R:M80	R:R:N351	9.82	No	Yes	3	9	9
55	R:R:V82	R:R:W163	4.9	No	Yes	0	7	9
56	R:R:C121	R:R:S83	5.16	No	No	0	8	9
57	R:R:S83	R:R:T125	4.8	No	No	0	9	9
58	R:R:D84	R:R:N351	6.73	No	Yes	0	9	9
59	R:R:C121	R:R:L86	6.35	No	No	0	8	7
60	R:R:I87	R:R:T122	4.56	Yes	No	1	7	8
61	R:R:F344	R:R:I87	8.79	Yes	Yes	1	9	7
62	R:R:I87	R:R:Y345	4.84	Yes	Yes	1	7	8
63	R:R:A348	R:R:L88	4.73	No	No	0	9	6
64	R:R:L91	R:R:L95	5.54	No	No	0	8	7
65	R:R:L91	R:R:Y345	12.89	No	Yes	0	8	8
66	R:R:F93	R:R:P92	4.33	No	No	0	6	9
67	R:R:D94	R:R:R97	5.96	Yes	No	1	7	6
68	R:R:D94	R:R:L341	6.79	Yes	No	1	7	6
69	R:R:D94	R:R:Y345	4.6	Yes	Yes	1	7	8
70	R:R:R100	R:R:Y96	28.81	No	No	0	5	5
71	R:R:V105	R:R:Y96	5.05	No	No	0	5	5
72	R:R:F106	R:R:Y96	18.57	No	No	0	7	5
73	R:R:R97	R:R:W104	9	No	Yes	0	6	8
74	R:R:I338	R:R:L98	4.28	No	No	0	6	6
75	R:R:P103	R:R:R100	5.76	No	No	0	7	5
76	R:R:R102	R:R:R233	20.26	No	Yes	1	6	4
77	R:R:E234	R:R:R102	16.28	Yes	No	1	4	6
78	R:R:R102	R:R:R236	4.26	No	Yes	1	6	5
79	R:R:F106	R:R:W104	6.01	No	Yes	0	7	8
80	R:R:C111	R:R:W104	10.45	No	Yes	0	9	8
81	R:R:E180	R:R:W104	6.54	No	Yes	0	4	8
82	R:R:G107	R:R:L110	5.13	No	No	0	9	6
83	R:R:E180	R:R:P108	4.72	No	No	0	4	3
84	R:R:L109	R:R:R112	4.86	No	No	0	3	8
85	R:R:C111	R:R:C235	7.28	No	No	0	9	9
86	R:R:F175	R:R:R112	4.28	No	No	0	5	8
87	R:R:L115	R:R:S114	4.5	No	No	0	5	6
88	R:R:L167	R:R:Y116	8.21	No	Yes	0	4	6
89	R:R:L174	R:R:Y116	9.38	No	Yes	0	5	6
90	R:R:E119	R:R:Y123	11.22	No	Yes	0	6	7
91	R:R:E119	R:R:F173	13.99	No	No	0	6	5
92	R:R:E119	R:R:R318	6.98	No	Yes	0	6	7
93	R:R:F344	R:R:T122	5.19	Yes	No	1	9	8
94	R:R:T252	R:R:Y123	4.99	No	Yes	0	7	7
95	R:R:Y123	R:R:Y255	16.88	Yes	No	0	7	7
96	R:R:A124	R:R:W163	5.19	No	Yes	0	8	9
97	R:R:L126	R:R:W311	12.53	No	No	0	7	8
98	R:R:L127	R:R:L162	6.92	No	No	0	7	8
99	R:R:L127	R:R:Y255	5.86	No	No	0	7	7
100	R:R:H128	R:R:L162	5.14	No	No	0	8	8
101	R:R:H128	R:R:W163	4.23	No	Yes	0	8	9
102	R:R:M129	R:R:N351	5.61	No	Yes	3	7	9
103	R:R:M129	R:R:Y355	7.18	No	Yes	3	7	9
104	R:R:P259	R:R:T130	5.25	No	No	0	9	7
105	R:R:L132	R:R:Y355	5.86	No	Yes	0	8	9
106	R:R:L266	R:R:S133	6.01	Yes	No	0	7	9
107	R:R:S133	R:R:Y267	7.63	No	Yes	0	9	8
108	R:R:R136	R:R:Y267	11.32	No	Yes	0	9	8
109	R:R:C141	R:R:Y137	10.75	No	Yes	0	7	7
110	R:R:L266	R:R:Y137	12.89	Yes	Yes	0	7	7
111	R:R:L269	R:R:Y137	7.03	No	Yes	0	5	7
112	R:R:I140	R:R:I270	7.36	No	No	0	8	8
113	R:R:E273	R:R:I140	5.47	No	No	0	5	8
114	R:R:P143	R:R:R142	4.32	No	No	0	8	6
115	R:R:L144	R:R:R147	9.72	No	No	0	6	6
116	R:R:R154	R:R:T151	12.94	No	No	0	6	8
117	R:R:R152	R:R:R156	4.26	No	No	0	5	4
118	R:R:A157	R:R:R153	6.91	No	No	0	3	4
119	R:R:S169	R:R:Y255	7.63	No	No	0	6	7
120	R:R:M248	R:R:P172	8.39	No	No	0	6	9
121	R:R:F173	R:R:M248	12.44	No	No	0	5	6
122	R:R:G178	R:R:V177	5.52	No	No	0	5	6
123	R:R:P237	R:R:V177	8.84	Yes	No	0	5	6
124	R:R:S238	R:R:V179	6.46	No	No	0	5	6
125	R:R:Q181	R:R:R236	17.52	No	Yes	0	4	5
126	R:R:Q181	R:R:S238	8.66	No	No	0	4	5
127	R:R:P239	R:R:Q181	4.74	No	No	0	7	4
128	R:R:D182	R:R:P183	6.44	No	No	0	4	6
129	R:R:D182	R:R:R233	4.76	No	Yes	0	4	4
130	R:R:E234	R:R:R233	4.65	Yes	Yes	1	4	4
131	R:R:R233	R:R:R236	10.66	Yes	Yes	1	4	5
132	R:R:E234	R:R:R236	11.63	Yes	Yes	1	4	5
133	R:R:P237	R:R:Q241	4.74	Yes	No	0	5	4
134	R:R:L242	R:R:P237	9.85	No	Yes	0	3	5
135	R:R:L245	R:R:P237	4.93	No	Yes	0	4	5
136	R:R:Q241	R:R:S238	8.66	No	No	0	4	5
137	R:R:L245	R:R:L249	6.92	No	No	0	4	5
138	R:R:R246	R:R:W250	11	No	No	2	5	5
139	R:R:I322	R:R:R246	12.53	Yes	No	2	6	5
140	R:R:N323	R:R:R246	13.26	No	No	2	5	5
141	R:R:L249	R:R:M248	4.24	No	No	0	5	6
142	R:R:I322	R:R:L249	4.28	Yes	No	0	6	5
143	R:R:I319	R:R:W250	17.62	No	No	2	6	5
144	R:R:I322	R:R:W250	7.05	Yes	No	2	6	5
145	R:R:R318	R:R:T252	9.06	Yes	No	0	7	7
146	R:R:F256	R:R:F257	9.65	No	No	0	8	5
147	R:R:F256	R:R:L312	7.31	No	No	0	8	6
148	R:R:F256	R:R:H315	13.58	No	No	0	8	8
149	R:R:F260	R:R:F307	4.29	No	No	0	7	9
150	R:R:F260	R:R:I308	5.02	No	No	0	7	7
151	R:R:C262	R:R:L266	4.76	No	Yes	0	6	7
152	R:R:L263	R:R:Y267	5.86	No	Yes	0	8	8
153	R:R:F307	R:R:L263	4.87	No	No	0	9	8
154	R:R:L300	R:R:Y267	9.38	No	Yes	0	9	8
155	R:R:L269	R:R:R272	6.07	No	No	0	5	5
156	R:R:E273	R:R:L274	5.3	No	No	0	5	8
157	R:R:R294	R:R:W275	5	No	No	0	7	3
158	R:R:V297	R:R:W275	7.36	No	No	0	7	3
159	R:R:I358	R:R:V299	6.14	No	No	0	7	8
160	R:R:L354	R:R:V303	5.96	No	No	0	8	8
161	R:R:F307	R:R:W311	9.02	No	No	0	9	8
162	R:R:F314	R:R:W311	5.01	Yes	No	0	6	8
163	R:R:L312	R:R:P313	4.93	No	No	0	6	9
164	R:R:F314	R:R:H315	9.05	Yes	No	1	6	8
165	R:R:F314	R:R:R318	9.62	Yes	Yes	1	6	7
166	R:R:F314	R:R:F344	4.29	Yes	Yes	1	6	9
167	R:R:H315	R:R:R318	7.9	No	Yes	1	8	7
168	R:R:F336	R:R:V316	6.55	No	No	0	5	6
169	R:R:G317	R:R:I320	7.05	No	No	0	6	6
170	R:R:F336	R:R:G317	4.52	No	No	0	5	6
171	R:R:G317	R:R:N337	5.09	No	No	0	6	6
172	R:R:I319	R:R:I322	8.83	No	Yes	2	6	6
173	R:R:I322	R:R:N323	4.25	Yes	No	2	6	5
174	R:R:M330	R:R:T324	7.53	No	No	0	4	4
175	R:R:F332	R:R:M329	7.46	No	No	0	4	3
176	R:R:M330	R:R:S333	4.6	No	No	0	4	7
177	R:R:M330	R:R:Q334	8.16	No	No	0	4	5
178	R:R:Y331	R:R:Y335	10.92	No	No	0	3	4
179	R:R:L341	R:R:Y345	8.21	No	Yes	1	6	8
180	R:R:F344	R:R:Y345	12.38	Yes	Yes	1	9	8
181	R:R:I350	R:R:L346	5.71	No	No	0	7	7
182	R:R:I350	R:R:L354	4.28	No	No	0	7	8
183	R:R:N351	R:R:P352	4.89	Yes	No	0	9	9
184	R:R:N351	R:R:Y355	8.14	Yes	Yes	3	9	9
185	R:R:I353	R:R:L357	5.71	No	No	0	8	6
186	R:R:N356	R:R:Y362	18.61	No	Yes	4	8	9
187	R:R:K360	R:R:R363	8.66	No	No	0	4	9
188	R:R:L176	R:R:L245	4.15	No	No	0	5	4
189	R:R:L301	R:R:L305	4.15	No	No	0	6	6
190	R:R:G107	R:R:P108	4.06	No	No	0	9	3
191	R:R:G171	R:R:P172	4.06	No	No	0	5	9
192	R:R:R153	R:R:T151	3.88	No	No	0	4	8
193	R:R:V58	R:R:Y362	3.79	No	Yes	0	6	9
194	R:R:V303	R:R:Y355	3.79	No	Yes	0	8	9
195	R:R:F332	R:R:I320	3.77	No	No	0	4	6
196	R:R:A146	R:R:P143	3.74	No	No	0	7	8
197	R:R:G52	R:R:S349	3.71	No	No	0	8	8
198	R:R:G55	R:R:S54	3.71	No	No	0	9	5
199	R:R:I270	R:R:Y137	3.63	No	Yes	0	8	7
200	R:R:P32	R:R:S31	3.56	No	No	0	3	7
201	R:R:P40	R:R:V39	3.53	No	No	0	5	8
202	R:R:G64	R:R:I63	3.53	No	No	0	4	8
203	R:R:L158	R:R:Y76	3.52	No	Yes	0	5	8
204	R:R:C310	R:R:S347	3.44	No	No	0	9	9
205	R:R:I353	R:R:P352	3.39	No	No	0	8	9
206	R:R:C262	R:R:T130	3.38	No	No	0	6	7
207	R:R:L258	R:R:P259	3.28	No	No	0	5	9
208	R:R:C121	R:R:I87	3.27	No	Yes	0	8	7
209	R:R:V148	R:R:V150	3.21	No	No	0	6	6
210	R:R:A81	R:R:N56	3.13	No	Yes	0	9	9
211	R:R:I320	R:R:S333	3.1	No	No	0	6	7
212	R:R:A348	R:R:D84	3.09	No	No	0	9	9
213	R:R:A229	R:R:E226	3.02	No	No	0	2	1
214	R:R:F93	R:R:G90	3.01	No	No	0	6	7
215	R:R:G178	R:R:R112	3	No	No	0	5	8
216	R:R:L35	R:R:V39	2.98	No	No	0	6	8
217	R:R:L48	R:R:V44	2.98	No	No	0	6	5
218	R:R:L113	R:R:V117	2.98	No	No	0	5	6
219	R:R:L127	R:R:V165	2.98	No	No	0	7	5
220	R:R:L138	R:R:V134	2.98	No	No	0	5	7
221	R:R:L138	R:R:V148	2.98	No	No	0	5	6
222	R:R:L263	R:R:V304	2.98	No	No	0	8	8
223	R:R:L46	R:R:T42	2.95	No	No	0	4	6
224	R:R:L274	R:R:T296	2.95	No	No	0	8	7
225	R:R:G171	R:R:Y116	2.9	No	Yes	0	5	6
226	R:R:Q342	R:R:V339	2.87	No	No	0	6	6
227	R:R:M69	R:R:N74	2.8	No	No	0	8	8
228	R:R:L35	R:R:L38	2.77	No	No	0	6	6
229	R:R:D68	R:R:K361	2.77	No	No	0	6	7
230	R:R:D326	R:R:M329	2.77	No	No	0	5	3
231	R:R:A170	R:R:Y116	2.67	No	Yes	0	8	6
232	R:R:A170	R:R:Y123	2.67	No	Yes	0	8	7
233	R:R:F344	R:R:S347	2.64	Yes	No	0	9	9
234	R:R:F257	R:R:T253	2.59	No	No	0	5	6
235	R:R:H293	R:R:L274	2.57	No	No	0	7	8
236	R:R:S359	R:R:Y362	2.54	No	Yes	0	9	9
237	R:R:V117	R:R:Y116	2.52	No	Yes	0	6	6
238	R:R:L369	R:R:R65	2.43	No	No	0	5	6
239	R:R:L138	R:R:R142	2.43	No	No	0	5	6
240	R:R:M69	R:R:Y362	2.39	No	Yes	0	8	9
241	R:R:A81	R:R:G78	1.95	No	No	0	9	7
242	R:R:A170	R:R:G120	1.95	No	No	0	8	5
243	R:R:G52	R:R:V51	1.84	No	No	0	8	5
244	R:R:G55	R:R:V58	1.84	No	No	0	9	6
245	R:R:G118	R:R:V117	1.84	No	No	0	7	6
246	R:R:G271	R:R:V297	1.84	No	No	0	6	7
247	R:R:A124	R:R:A166	1.79	No	No	0	8	8
248	R:R:P103	R:R:S101	1.78	No	No	0	7	5
249	R:R:G271	R:R:I270	1.76	No	No	0	6	8
250	R:R:G52	R:R:L88	1.71	No	No	0	8	6
251	R:R:A81	R:R:V60	1.7	No	No	0	9	7
252	R:R:G292	R:R:Q295	1.64	No	No	0	6	8
253	R:R:C310	R:R:I309	1.64	No	No	0	9	6
254	R:R:A139	R:R:I140	1.62	No	No	0	8	8
255	R:R:A306	R:R:I350	1.62	No	No	0	7	7
256	R:R:V299	R:R:V303	1.6	No	No	0	8	8
257	R:R:C310	R:R:L343	1.59	No	No	0	9	8
258	R:R:A366	R:R:L62	1.58	No	No	0	7	8
259	R:R:A131	R:R:L162	1.58	No	No	0	8	8
260	R:R:A157	R:R:L158	1.58	No	No	0	3	5
261	R:R:A244	R:R:L176	1.58	No	No	0	5	5
262	R:R:A227	R:R:L230	1.58	No	No	0	3	2
263	R:R:T71	R:R:T73	1.57	No	No	0	8	8
264	R:R:A340	R:R:N337	1.56	No	No	0	7	6
265	R:R:A240	R:R:Q241	1.52	No	No	0	6	4
266	R:R:L48	R:R:S349	1.5	No	No	0	6	8
267	R:R:L85	R:R:V57	1.49	No	No	0	7	5
268	R:R:L301	R:R:V304	1.49	No	No	0	6	8
269	R:R:L354	R:R:V302	1.49	No	No	0	8	6
270	R:R:G268	R:R:Y267	1.45	No	Yes	0	5	8
271	R:R:I265	R:R:L261	1.43	No	No	0	4	4
272	R:R:I265	R:R:L266	1.43	No	Yes	0	4	7
273	R:R:I265	R:R:L269	1.43	No	No	0	4	5
274	R:R:R328	R:R:S327	1.32	No	No	0	4	5
275	R:R:R298	R:R:V299	1.31	No	No	0	6	8
276	R:R:D326	R:R:E325	1.3	No	No	0	5	3
277	R:R:L149	R:R:R154	1.21	No	No	0	4	6
278	R:R:F231	R:R:R233	1.07	No	Yes	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.32375	8	1	0
2	R:R:N56	7.705	4	0	9
3	R:R:Y76	5.96	5	0	8
4	R:R:I87	5.365	4	1	7
5	R:R:D94	6.0775	4	1	7
6	R:R:W104	8	4	0	8
7	R:R:Y116	5.136	5	0	6
8	R:R:Y123	8.94	4	0	7
9	R:R:Y137	8.575	4	0	7
10	R:R:W163	4.815	4	0	9
11	R:R:R233	8.28	5	1	4
12	R:R:E234	11.1125	4	1	4
13	R:R:R236	11.0175	4	1	5
14	R:R:P237	7.09	4	0	5
15	R:R:L266	6.2725	4	0	7
16	R:R:Y267	7.128	5	0	8
17	R:R:F314	6.686	5	1	6
18	R:R:R318	8.39	4	1	7
19	R:R:I322	7.388	5	2	6
20	R:R:F344	6.658	5	1	9
21	R:R:Y345	8.584	5	1	8
22	R:R:N351	7.038	5	3	9
23	R:R:Y355	5.932	5	3	9
24	R:R:Y362	7.19667	6	4	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L98	35.0059	5.32	Yes	No	0	0	6
2	R:R:I338	R:R:L98	33.9885	4.28	No	No	0	6	6
3	R:R:F33	R:R:I338	29.4926	6.28	No	No	0	6	6
4	R:R:F33	R:R:S31	23.8967	5.28	No	No	0	6	7
5	R:R:P32	R:R:S31	18.9581	3.56	No	No	0	3	7
6	R:R:P32	R:R:Q334	17.7326	4.74	No	No	0	3	5
7	R:R:L91	R:R:Y345	14.2145	12.89	No	Yes	0	8	8
8	L:L:?1	R:R:F314	59.9762	5.46	Yes	Yes	1	0	6
9	R:R:F314	R:R:R318	98.3417	9.62	Yes	Yes	1	6	7
10	R:R:E119	R:R:R318	55.1698	6.98	No	Yes	0	6	7
11	R:R:E119	R:R:Y123	56.6134	11.22	No	Yes	0	6	7
12	R:R:Y123	R:R:Y255	100	16.88	Yes	No	0	7	7
13	R:R:L127	R:R:Y255	98.7117	5.86	No	No	0	7	7
14	R:R:L127	R:R:L162	97.3969	6.92	No	No	0	7	8
15	R:R:H128	R:R:L162	96.0558	5.14	No	No	0	8	8
16	R:R:H128	R:R:W163	95.3753	4.23	No	Yes	0	8	9
17	R:R:S79	R:R:W163	92.5872	4.94	No	Yes	0	9	9
18	R:R:I159	R:R:S79	91.8737	7.74	No	No	0	8	9
19	R:R:I159	R:R:Y76	91.1535	9.67	No	Yes	0	8	8
20	R:R:L132	R:R:Y76	68.5452	4.69	No	Yes	0	8	8
21	R:R:L132	R:R:Y355	67.6467	5.86	No	Yes	0	8	9
22	R:R:N351	R:R:Y355	30.7182	8.14	Yes	Yes	3	9	9
23	R:R:D84	R:R:N351	17.4187	6.73	No	Yes	0	9	9
24	R:R:R318	R:R:T252	48.639	9.06	Yes	No	0	7	7
25	R:R:T252	R:R:Y123	48.5795	4.99	No	Yes	0	7	7
26	R:R:N351	R:R:P352	11.2249	4.89	Yes	No	0	9	9
27	R:R:L77	R:R:Y355	29.4331	4.69	No	Yes	0	9	9
28	R:R:L77	R:R:N356	28.2737	10.98	No	No	0	9	8
29	R:R:N356	R:R:Y362	25.958	18.61	No	Yes	4	8	9
30	R:R:M69	R:R:Y362	11.5916	2.39	No	Yes	0	8	9
31	R:R:E135	R:R:Y76	10.9904	5.61	No	Yes	0	8	8
32	R:R:V155	R:R:Y76	14.6769	6.31	No	Yes	0	7	8
33	R:R:F314	R:R:F344	24.151	4.29	Yes	Yes	1	6	9
34	L:L:?1	R:R:R97	16.0082	6.23	Yes	No	1	0	6
35	R:R:R97	R:R:W104	16.1073	9	No	Yes	0	6	8
36	L:L:?1	R:R:E234	17.8944	11.89	Yes	Yes	1	0	4
37	R:R:E234	R:R:R236	10.66	11.63	Yes	Yes	1	4	5
38	R:R:A170	R:R:Y123	11.2844	2.67	No	Yes	0	8	7
39	R:R:F314	R:R:W311	43.7236	5.01	Yes	No	0	6	8
40	R:R:F307	R:R:W311	41.6557	9.02	No	No	0	9	8
41	R:R:F307	R:R:L263	38.5042	4.87	No	No	0	9	8
42	R:R:L263	R:R:Y267	34.2924	5.86	No	Yes	0	8	8
43	R:R:S133	R:R:Y267	29.8923	7.63	No	Yes	0	9	8
44	R:R:L266	R:R:S133	28.7758	6.01	Yes	No	0	7	9
45	R:R:L266	R:R:Y137	18.3173	12.89	Yes	Yes	0	7	7
46	R:R:I270	R:R:Y137	13.6595	3.63	No	Yes	0	8	7
47	R:R:T72	R:R:V150	17.1446	4.76	No	No	0	7	6
48	R:R:V148	R:R:V150	14.8058	3.21	No	No	0	6	6
49	R:R:L138	R:R:V148	12.467	2.98	No	No	0	5	6
50	R:R:E119	R:R:F173	14.7628	13.99	No	No	0	6	5
51	R:R:F173	R:R:M248	14.1352	12.44	No	No	0	5	6
52	R:R:L249	R:R:M248	12.936	4.24	No	No	0	5	6
53	R:R:V303	R:R:Y355	11.476	3.79	No	Yes	0	8	9
54	R:R:M330	R:R:Q334	16.616	8.16	No	No	0	4	5
55	R:R:M330	R:R:S333	14.1319	4.6	No	No	0	4	7
56	R:R:I320	R:R:S333	12.8799	3.1	No	No	0	6	7
57	R:R:F344	R:R:Y345	12.0078	12.38	Yes	Yes	1	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D94	6.96	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R97	6.23	1	Yes	No	0	6	0	1
L:L:?1	R:R:L98	5.32	1	Yes	No	0	6	0	1
L:L:?1	R:R:L115	7.1	1	Yes	No	0	5	0	1
L:L:?1	R:R:E234	11.89	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:F314	5.46	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y321	6.76	1	Yes	No	0	5	0	1
L:L:?1	R:R:L341	8.87	1	Yes	No	0	6	0	1
R:R:D94	R:R:R97	5.96	1	Yes	No	7	6	1	1
R:R:D94	R:R:L341	6.79	1	Yes	No	7	6	1	1
R:R:D94	R:R:Y345	4.6	1	Yes	Yes	7	8	1	2
R:R:R97	R:R:W104	9	1	No	Yes	6	8	1	2
R:R:I338	R:R:L98	4.28	0	No	No	6	6	2	1
R:R:R102	R:R:R233	20.26	1	No	Yes	6	4	2	2
R:R:E234	R:R:R102	16.28	1	Yes	No	4	6	1	2
R:R:R102	R:R:R236	4.26	1	No	Yes	6	5	2	2
R:R:L115	R:R:S114	4.5	0	No	No	5	6	1	2
R:R:E234	R:R:R233	4.65	1	Yes	Yes	4	4	1	2
R:R:R233	R:R:R236	10.66	1	Yes	Yes	4	5	2	2
R:R:E234	R:R:R236	11.63	1	Yes	Yes	4	5	1	2
R:R:F314	R:R:W311	5.01	1	Yes	No	6	8	1	2
R:R:F314	R:R:H315	9.05	1	Yes	No	6	8	1	2
R:R:F314	R:R:R318	9.62	1	Yes	Yes	6	7	1	2
R:R:F314	R:R:F344	4.29	1	Yes	Yes	6	9	1	2
R:R:H315	R:R:R318	7.9	1	No	Yes	8	7	2	2
R:R:L341	R:R:Y345	8.21	1	No	Yes	6	8	1	2
R:R:F344	R:R:Y345	12.38	1	Yes	Yes	9	8	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9JMD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	4.16
Number of Linked Nodes	263
Number of Links	278
Number of Hubs	24
Number of Links mediated by Hubs	98
Number of Communities	4
Number of Nodes involved in Communities	27
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	58
Number Of Links MetaPath	57
Number of Shortest Paths	51229
Length Of Smallest Path	3
Average Path Length	17.3189
Length of Longest Path	37
Minimum Path Strength	1.43
Average Path Strength	6.95208
Maximum Path Strength	23.69
Minimum Path Correlation	0.7
Average Path Correlation	0.932041
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	49.0495
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.6929
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ZIT
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ZIT
Name	Azithromycin
Synonyms	Azithromycine
Identifier
Formula	C38 H72 N2 O12
Molecular Weight	748.984
SMILES
PubChem	447043
Formal Charge	0
Total Atoms	124
Total Chiral Atoms	18
Total Bonds	126
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O43193
Sequence	>9JMD_nogp_Chain_R S P F P L G A L V P V T A V C L C L F V V G V S G N V V T V M L I G R Y R D M R T T T N L Y L G S M A V S D L L I L L G L P F D L Y R L W R S R P W V F G P L L C R L S L Y V G E G C T Y A T L L H M T A L S V E R Y L A I C R P L R A R V L V T R R R V R A L I A V L W A V A L L S A G P F L F L V G V E Q D P E A A A L F S R E C R P S P A Q L G A L R V M L W V T T A Y F F L P F L C L S I L Y G L I G R E L W S R G H R Q T V R V L L V V V L A F I I C W L P F H V G R I I Y I N T E D S R M M Y F S Q Y F N I V A L Q L F Y L S A S I N P I L Y N L I S K K Y R A A A F K L L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8IBU	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.51	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBU (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Erythromycin-A	-		3.51	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBV	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.19	2023-04-12	doi.org/10.1126/sciadv.ade9020
	8IBV (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Motilin	-		3.19	2023-04-12	doi.org/10.1126/sciadv.ade9020
	9JMC	A	Peptide	Motilin	Motilin	Homo sapiens	DS-3801b	-	chim(Gs-CtGq)/β1/γ2	2.57	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMC (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	DS-3801b	-		2.57	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMD	A	Peptide	Motilin	Motilin	Homo sapiens	Azithromycin	-	chim(Gs-CtGq)/β1/γ2	2.74	2025-05-28	doi.org/10.1016/j.celrep.2025.115329
	9JMD (No Gprot)	A	Peptide	Motilin	Motilin	Homo sapiens	Azithromycin	-		2.74	2025-05-28	doi.org/10.1016/j.celrep.2025.115329

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9JMD_nogp.zip

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