Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:Q30 9.17754184
2R:R:I34 5.9675407
3R:R:V41 4407
4R:R:Y57 10.442565
5R:R:N63 4.99754239
6R:R:L81 7.1525408
7R:R:W93 8.9256108
8R:R:F95 11.4445106
9R:R:W99 9.4854105
10R:R:Y107 6.116528
11R:R:L108 3.84406
12R:R:L118 7.2775479
13R:R:I121 5.1975479
14R:R:R125 9.4825479
15R:R:Y126 5.99254159
16R:R:Y127 6.044155
17R:R:L130 4.71254156
18R:R:Y131 5.744156
19R:R:P132 4.27499
20R:R:Y135 6.555408
21R:R:P136 5.5075405
22R:R:W152 5.602509
23R:R:P161 6.11426
24R:R:W166 9.715426
25R:R:D172 7.42423
26R:R:F174 11.1625422
27R:R:K175 9.26667622
28R:R:W176 5.685403
29R:R:M177 6.2325423
30R:R:V179 4.9875423
31R:R:W182 7.74143725
32R:R:R184 5.14254253
33R:R:Y188 5.19143728
34R:R:F191 5.795424
35R:R:W192 4.53833626
36R:R:W195 12.36404
37R:R:F201 6.068506
38R:R:Y208 5.845679
39R:R:F212 5.83754266
40R:R:F279 7.26579
41R:R:W283 8.90875878
42R:R:Y286 6.95714727
43R:R:M287 4.924507
44R:R:I290 7.31427
45R:R:E293 8.2925424
46R:R:K298 6.71521
47R:R:V301 3.558524
48R:R:E306 9.63525
49R:R:W311 6.7425187
50R:R:F314 6.166527
51R:R:H320 7.65479
52R:R:Y324 6.54579
53A:A:Y37 7.554194
54A:A:L44 9.435419
55A:A:L46 4.78418
56A:A:K53 6.69254289
57A:A:F219 6.792508
58A:A:F222 7.2675417
59A:A:Q227 4.436539
60A:A:R231 4.475409
61A:A:K233 7.25333639
62A:A:F238 11.3325419
63A:A:D240 6.5225416
64A:A:I244 4.924518
65A:A:F246 5.755419
66A:A:V247 3.6175407
67A:A:Y253 8.59408
68A:A:R265 3.0025409
69A:A:L270 5.516506
70A:A:F273 5.62571719
71A:A:W277 10.222516
72A:A:W281 14.425415
73A:A:L282 7.015409
74A:A:L289 5.746519
75A:A:F290 5.8185209
76A:A:N292 4.06409
77A:A:Y311 5.5125406
78A:A:F312 6.084218
79A:A:E314 4.00254216
80A:A:F315 13.726506
81A:A:P321 3.865405
82A:A:E330 7.96413
83A:A:D331 9.15414
84A:A:V334 4.48833614
85A:A:K338 8.6275415
86A:A:Y339 8.6075413
87A:A:F340 10.4185217
88A:A:R342 7.79514
89A:A:E344 8.074215
90A:A:F345 7.39418
91A:A:S349 4.48417
92A:A:C359 4.296515
93A:A:Y360 5.666598
94A:A:F363 9.306515
95A:A:T364 8.09254209
96A:A:D368 7.54754209
97A:A:N371 7.2185209
98A:A:R373 4.8054165
99A:A:F376 7.0356168
100A:A:I383 4.5925498
101A:A:H387 4.755498
102A:A:L388 4.6754248
103A:A:L394 4.2654248
104B:B:I18 5.094307
105B:B:R22 7.294306
106B:B:D27 6.82408
107B:B:L51 7.028589
108B:B:H54 8.7689
109B:B:K57 12.652519
110B:B:Y59 9.53418
111B:B:M61 4.67486
112B:B:W63 6.79667687
113B:B:Q75 9.336519
114B:B:D76 8.2085199
115B:B:L79 4.2245127
116B:B:W82 10.4167689
117B:B:D83 7.1525138
118B:B:T86 7.564136
119B:B:K89 8.228509
120B:B:L95 5.20754128
121B:B:W99 11.472519
122B:B:Y105 5.326676126
123B:B:Y111 6.316174
124B:B:V112 4.134128
125B:B:C121 4.59438
126B:B:I123 4.3925406
127B:B:Y124 5.418506
128B:B:L126 4.854125
129B:B:H142 6.49857739
130B:B:R145 6.28833638
131B:B:L146 3.904537
132B:B:C149 4.27438
133B:B:F151 4.982509
134B:B:L152 4.502553
135B:B:Q156 5.27455
136B:B:I157 5.625437
137B:B:V158 4.245455
138B:B:T159 5.60167639
139B:B:S161 6.7439
140B:B:D163 8.1525439
141B:B:L168 4.96456
142B:B:W169 9.18833638
143B:B:Q176 6.7725434
144B:B:F180 9.006557
145B:B:H183 8.33833659
146B:B:D186 6.002539
147B:B:L192 4.012555
148B:B:F199 7.12559
149B:B:V200 9.48446
150B:B:S201 4.6075459
151B:B:D205 7.53559
152B:B:K209 11.198556
153B:B:L210 6.838545
154B:B:W211 9.97658
155B:B:D212 7.7325449
156B:B:Q220 6.666547
157B:B:F222 8.8975448
158B:B:H225 9.152549
159B:B:D228 10.675439
160B:B:I229 6.2225447
161B:B:I232 5.65448
162B:B:F234 7.05405
163B:B:F235 7.33258116
164B:B:P236 7.07254117
165B:B:N237 7.545115
166B:B:F241 9.09667646
167B:B:T243 6.2975448
168B:B:D247 7.27409
169B:B:T249 4446
170B:B:R251 10.04448
171B:B:F253 8.125446
172B:B:D254 6.6075409
173B:B:R256 11.745409
174B:B:Y264 7.28333615
175B:B:F278 6.1845117
176B:B:R283 8.2454149
177B:B:L285 5.9625406
178B:B:Y289 9.06833617
179B:B:D290 6.388516
180B:B:N295 8.805416
181B:B:W297 9.164518
182B:B:H311 8.59167669
183B:B:R314 14.438518
184B:B:V315 4.11567
185B:B:C317 3.8975407
186B:B:T321 7.7475487
187B:B:W332 14.7967619
188B:B:D333 7.995469
189B:B:F335 8.415464
190B:B:K337 10.586566
191B:B:W339 7.48125869
192G:G:R27 6.7875408
193G:G:M38 3.99254144
194G:G:Y40 11.944116
195G:G:D48 8.22254319
196G:G:L51 4.9954316
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:I34 R:R:W311 11.649914.09YesYes077
2R:R:F314 R:R:I34 13.13763.77YesYes077
3R:R:L81 R:R:V41 28.58064.47YesYes087
4R:R:F314 R:R:L81 28.199412.18YesYes078
5R:R:A317 R:R:V41 30.86475.09NoYes097
6R:R:A317 R:R:N73 31.04014.69NoNo099
7R:R:N45 R:R:N73 95.069810.9NoNo099
8R:R:N45 R:R:T70 95.35244.39NoNo099
9R:R:T70 R:R:V49 95.77574.76NoNo097
10R:R:F67 R:R:V49 96.05735.24NoNo067
11R:R:F67 R:R:L52 96.33856.09NoNo067
12R:R:L52 R:R:N63 98.0174.12NoYes079
13R:R:N328 R:R:N63 98.26484.09NoYes2399
14R:R:N328 R:R:T330 98.57314.39NoNo097
15R:R:L58 R:R:T330 98.71195.9NoNo087
16R:R:L58 R:R:Y57 98.85058.21NoYes085
17B:B:F335 R:R:Y57 1008.25YesYes645
18R:R:I151 R:R:T117 55.89256.08NoNo068
19R:R:F314 R:R:Y107 18.87797.22YesYes278
20R:R:I151 R:R:W152 56.53923.52NoYes069
21R:R:I121 R:R:T117 54.8623.04YesNo098
22R:R:S114 R:R:S72 64.36393.26NoNo098
23R:R:N73 R:R:S114 64.50510.43NoNo099
24R:R:A128 R:R:Y135 17.33448.01NoYes088
25A:A:Y391 R:R:A128 37.6144NoNo048
26A:A:Y391 R:R:R125 58.552216.46NoYes049
27R:R:I139 R:R:Y135 15.95254.84NoYes068
28R:R:I139 R:R:Y127 15.55678.46NoYes065
29A:A:H387 R:R:A128 21.05094.39YesNo088
30A:A:H387 A:A:Q390 20.57684.95YesNo084
31A:A:Q390 A:A:Y391 20.767213.53NoNo044
32R:R:L130 R:R:V129 13.35162.98YesNo069
33A:A:H387 R:R:P132 13.47563.05YesYes989
34A:A:H387 A:A:I383 27.75216.63YesYes988
35A:A:F219 A:A:H41 25.79667.92YesNo086
36A:A:H41 A:A:I383 26.97583.98NoYes068
37B:B:D333 B:B:F335 64.195313.14YesYes694
38B:B:F335 B:B:K337 36.11213.72YesYes646
39B:B:R314 B:B:W332 35.680134.99YesYes189
40B:B:R314 B:B:T274 48.60969.06YesNo188
41B:B:S275 B:B:T274 97.14983.2NoNo088
42B:B:L318 B:B:S275 97.18569.01NoNo068
43B:B:L318 B:B:V315 97.25912.98NoYes067
44B:B:H311 B:B:V315 65.01495.54YesYes697
45B:B:D333 B:B:H311 32.26476.3YesYes699
46B:B:S331 B:B:V315 32.20573.23NoYes697
47B:B:D333 B:B:S331 32.18195.89YesNo699
48B:B:H311 B:B:K337 32.297814.41YesYes696
49B:B:W332 B:B:Y59 28.97679.65YesYes198
50A:A:F219 A:A:L43 19.90333.65YesNo087
51A:A:I245 A:A:L43 19.50855.71NoNo077
52A:A:F290 A:A:I375 18.71995.02YesNo099
53A:A:I245 A:A:I375 19.11425.89NoNo079
54B:B:M101 B:B:R145 25.57369.93NoYes098
55A:A:C237 B:B:M101 25.76844.86NoNo089
56A:A:C237 B:B:Y59 25.51666.72NoYes188
57A:A:F273 A:A:W277 21.80327.02YesYes196
58A:A:H357 A:A:W277 43.561225.39NoYes076
59A:A:H357 A:A:R356 43.92783.39NoNo072
60A:A:R283 A:A:R356 44.34388.53NoNo032
61A:A:R280 A:A:R283 44.57824.26NoNo053
62A:A:R280 A:A:W281 43.949324.99NoYes055
63A:A:W281 B:B:R314 20.956114.99YesYes158
64A:A:W281 B:B:D290 23.423410.05YesYes156
65B:B:D290 B:B:T274 48.50434.34YesNo168
66A:A:C359 A:A:W277 13.16153.92YesYes156
67A:A:L289 A:A:L291 10.6066.92YesNo098
68A:A:K338 A:A:V334 12.38323.04YesYes154
69A:A:F363 A:A:K338 15.922411.17YesYes155
70A:A:E344 A:A:L270 11.55816.63YesYes056
71G:G:A23 G:G:K20 10.90723.21NoNo086
72B:B:I18 G:G:A23 11.45141.62YesNo078
73B:B:I18 G:G:R27 15.80173.76YesYes078
74B:B:D258 G:G:R27 12.609215.48NoYes078
75B:B:L210 B:B:V200 10.044.47YesYes456
76B:B:F234 B:B:V200 15.473614.42YesYes056
77B:B:F234 B:B:S191 15.26196.61YesNo058
78B:B:C233 B:B:S191 15.38833.44NoNo038
79B:B:C233 B:B:F278 15.77474.19NoYes037
80B:B:F278 B:B:L285 20.29989.74YesYes076
81B:B:L285 B:B:Y264 20.679.38YesYes065
82B:B:W297 B:B:Y264 29.184415.43YesYes185
83B:B:W297 B:B:Y289 36.55489.65YesYes187
84B:B:C271 B:B:Y289 37.50924.03NoYes157
85B:B:C271 B:B:D290 38.13814.67NoYes156
86B:B:C148 B:B:T102 13.14373.38NoNo068
87B:B:C149 B:B:T102 13.40885.07YesNo088
88B:B:H142 B:B:S161 23.539715.34YesYes399
89B:B:G162 B:B:S161 24.853.71NoYes399
90B:B:G162 B:B:R145 24.90396NoYes398
91B:B:H142 B:B:T159 10.01258.21YesYes399
92R:R:S72 R:R:W152 63.80844.94NoYes089
93R:R:I121 R:R:R125 52.97025.01YesYes799
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8KH4
Class A
SubFamily Orphan
Type A orphans
SubType GPR161
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.1
Date 2023-10-11
D.O.I. 10.1038/s41467-023-41654-3
Net Summary
Imin 2.98
Number of Linked Nodes 842
Number of Links 1085
Number of Hubs 196
Number of Links mediated by Hubs 687
Number of Communities 31
Number of Nodes involved in Communities 287
Number of Links involved in Communities 419
Path Summary
Number Of Nodes in MetaPath 94
Number Of Links MetaPath 93
Number of Shortest Paths 2565805
Length Of Smallest Path 3
Average Path Length 37.6195
Length of Longest Path 68
Minimum Path Strength 1.07
Average Path Strength 7.10392
Maximum Path Strength 30.26
Minimum Path Correlation 0.7
Average Path Correlation 0.984557
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2
Average % Of Corr. Nodes 34.4161
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 46.5787
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8N6U8
Sequence
>8KH4_Chain_R
IITQFIAII VITIFVCLG NLVIVVTLY KKSYLLTLS NKFVFSLTL 
SNFLLSVLV LPFVVTSSI RREWIFGVV WCNFSALLY LLISSASML 
TLGVIAIDR YYAVLYPMV YPMKITGNR AVMALVYIW LHSLIGCLP 
PLFGWSSVE FDEFKWMCV AAWHREPGY TAFWQIWCA LFPFLVMLV 
CYGFIFRVA RVKACKALI TILVVLGAF MVTWGPYMV VIASEALWG 
KSSVSPSLE TWATWLSFA SAVCHPLIY GLWNKTVRK ELLGM


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8KH4_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRIFET KFQVDKVNF HMFDVGGQR DERRKWIQC FNDVTAIIF 
VVDSSDYNR LQEALNLFK SIWNNRWLR TISVILFLN KQDLLAEKV 
LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA KYFIRDEFL 
RISTASGDG RHYCYPHFT CAVDTENAR RIFNDCRDI IQRMHLRQY 
ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8KH4_Chain_B
DQLRQEAEQ LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR 
TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP 
LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE GNVRVSREL 
AGHTGRLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ QTTTFTGHT 
GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ TFTGHESDI 
NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS HDNIICGIT 
SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG HDNRVSCLG 
VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8KH4_Chain_G
IAQARKLVE QLKMEANID RIKVSKAAA DLMAYCEAH AKEDPLLT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8KH4AOrphanA orphansGPR161Homo sapiens--Gs/&β;1/&γ;23.12023-10-1110.1038/s41467-023-41654-3
8SMVAOrphanA orphansGPR161Homo sapiens--Gs/&β;1/&γ;22.742024-02-2110.1038/s41594-024-01223-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8KH4.zip



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