psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q30	R:R:T307	5.67	No	No	6	4	5
2	R:R:Q30	R:R:W308	6.57	No	No	0	4	5
3	R:R:Q30	R:R:W311	4.38	No	Yes	6	4	7
4	R:R:F31	R:R:I35	7.54	No	No	0	4	4
5	R:R:F31	R:R:V85	2.62	No	No	0	4	5
6	R:R:F31	R:R:I89	11.3	No	No	0	4	4
7	R:R:A33	R:R:W311	2.59	No	Yes	0	4	7
8	R:R:I34	R:R:V85	3.07	No	No	0	7	5
9	R:R:I34	R:R:S88	3.1	No	No	0	7	5
10	R:R:I34	R:R:W311	11.74	No	Yes	0	7	7
11	R:R:F40	R:R:V36	3.93	No	No	0	4	4
12	R:R:L81	R:R:T38	10.32	No	No	0	8	6
13	R:R:I39	R:R:L43	2.85	No	No	0	5	4
14	R:R:F40	R:R:V318	2.62	No	No	0	4	6
15	R:R:A317	R:R:V41	3.39	No	Yes	0	9	7
16	R:R:C42	R:R:F74	4.19	No	No	0	6	7
17	R:R:C42	R:R:S77	3.44	No	No	0	6	6
18	R:R:N45	R:R:T70	2.92	No	No	0	9	9
19	R:R:N45	R:R:N73	4.09	No	Yes	0	9	9
20	R:R:N45	R:R:P321	9.77	No	No	0	9	9
21	R:R:L46	R:R:V50	2.98	No	No	0	4	4
22	R:R:F74	R:R:L46	9.74	No	No	0	7	4
23	R:R:L335	R:R:V47	4.47	Yes	No	0	7	7
24	R:R:I48	R:R:T70	6.08	No	No	0	8	9
25	R:R:F67	R:R:V49	3.93	No	No	0	6	7
26	R:R:L335	R:R:T51	4.42	Yes	No	0	7	8
27	R:R:L52	R:R:L59	5.54	Yes	No	1	7	8
28	R:R:F67	R:R:L52	3.65	No	Yes	1	6	7
29	R:R:K55	R:R:Y57	5.97	No	No	1	6	5
30	R:R:K55	R:R:L58	2.82	No	Yes	1	6	8
31	R:R:E334	R:R:K55	8.1	No	No	1	7	6
32	R:R:L58	R:R:Y57	9.38	Yes	No	1	8	5
33	R:R:E334	R:R:Y57	6.73	No	No	1	7	5
34	R:R:E334	R:R:L58	3.98	No	Yes	1	7	8
35	R:R:F67	R:R:L59	3.65	No	No	1	6	8
36	R:R:N63	R:R:T60	8.77	No	No	0	9	7
37	R:R:I139	R:R:L61	4.28	No	No	0	6	5
38	R:R:A144	R:R:L61	3.15	No	No	0	7	5
39	R:R:N63	R:R:S62	2.98	No	No	0	9	8
40	R:R:F65	R:R:V120	5.24	Yes	No	0	8	6
41	R:R:F65	R:R:I121	2.51	Yes	Yes	0	8	9
42	R:R:F65	R:R:L148	4.87	Yes	No	0	8	7
43	R:R:V66	R:R:Y324	2.52	No	Yes	0	8	9
44	R:R:L148	R:R:S68	3	No	No	0	7	9
45	R:R:L69	R:R:N73	2.75	Yes	Yes	7	9	9
46	R:R:L69	R:R:S114	3	Yes	No	7	9	9
47	R:R:L69	R:R:T117	4.42	Yes	No	0	9	8
48	R:R:H320	R:R:L69	7.71	No	Yes	0	9	9
49	R:R:N73	R:R:S72	2.98	Yes	No	0	9	8
50	R:R:I110	R:R:S72	3.1	No	No	0	7	8
51	R:R:S72	R:R:W152	2.47	No	No	0	8	9
52	R:R:N73	R:R:S114	5.96	Yes	No	7	9	9
53	R:R:A317	R:R:N73	4.69	No	Yes	0	9	9
54	R:R:L76	R:R:V80	2.98	No	Yes	0	7	7
55	R:R:I110	R:R:L76	9.99	No	No	0	7	7
56	R:R:S77	R:R:V78	4.85	No	No	0	6	4
57	R:R:L106	R:R:L79	2.77	No	No	8	5	5
58	R:R:S103	R:R:V80	4.85	No	Yes	0	5	7
59	R:R:F314	R:R:L81	8.53	Yes	No	0	7	8
60	R:R:F83	R:R:W93	4.01	No	Yes	5	5	8
61	R:R:F83	R:R:F95	10.72	No	Yes	5	5	6
62	R:R:M177	R:R:V84	4.56	No	No	0	3	7
63	R:R:F95	R:R:T86	7.78	Yes	No	0	6	5
64	R:R:F171	R:R:S87	2.64	No	No	0	3	5
65	R:R:I89	R:R:S88	3.1	No	No	0	4	5
66	R:R:S88	R:R:W176	2.47	No	No	0	5	3
67	R:R:I94	R:R:R90	5.01	No	No	0	3	4
68	R:R:R91	R:R:W176	6	No	No	0	3	3
69	R:R:F95	R:R:W93	14.03	Yes	Yes	5	6	8
70	R:R:C100	R:R:W93	2.61	No	Yes	5	9	8
71	R:R:F171	R:R:W93	6.01	No	Yes	0	3	8
72	R:R:C178	R:R:W93	7.84	No	Yes	5	9	8
73	R:R:F95	R:R:I94	10.05	Yes	No	0	6	3
74	R:R:F102	R:R:V98	2.62	No	No	0	4	3
75	R:R:C100	R:R:C178	7.28	No	No	5	9	9
76	R:R:N101	R:R:V169	2.96	No	No	0	6	4
77	R:R:L105	R:R:L163	4.15	No	No	0	7	6
78	R:R:S111	R:R:Y107	7.63	No	Yes	0	6	8
79	R:R:Y107	R:R:Y286	2.98	Yes	Yes	2	8	7
80	R:R:S313	R:R:Y107	3.82	No	Yes	2	7	8
81	R:R:F314	R:R:Y107	4.13	Yes	Yes	2	7	8
82	R:R:L108	R:R:W192	3.42	No	Yes	0	6	6
83	R:R:S111	R:R:W283	4.94	No	Yes	0	6	8
84	R:R:S112	R:R:S155	6.52	No	No	0	7	8
85	R:R:C196	R:R:S112	3.44	No	No	0	7	7
86	R:R:A113	R:R:W152	7.78	No	No	0	8	9
87	R:R:A113	R:R:S155	3.42	No	No	0	8	8
88	R:R:F279	R:R:M115	6.22	No	No	0	9	8
89	R:R:M115	R:R:W283	4.65	No	Yes	0	8	8
90	R:R:H154	R:R:L116	9	No	No	0	4	6
91	R:R:L116	R:R:P200	4.93	No	No	0	6	9
92	R:R:I121	R:R:T117	3.04	Yes	No	0	9	8
93	R:R:I151	R:R:T117	3.04	No	No	0	6	8
94	R:R:L118	R:R:M204	2.83	Yes	Yes	0	9	8
95	R:R:F279	R:R:L118	2.44	No	Yes	0	9	9
96	R:R:H320	R:R:L118	5.14	No	Yes	0	9	9
97	R:R:L118	R:R:Y324	7.03	Yes	Yes	0	9	9
98	R:R:I151	R:R:V120	6.14	No	No	0	6	6
99	R:R:I121	R:R:R125	3.76	Yes	No	4	9	9
100	R:R:I121	R:R:Y324	3.63	Yes	Yes	4	9	9
101	R:R:A122	R:R:M204	3.22	No	Yes	4	9	8
102	R:R:A122	R:R:Y208	5.34	No	Yes	4	9	9
103	R:R:I123	R:R:Y127	2.42	No	Yes	0	6	5
104	R:R:I123	R:R:V203	3.07	No	No	0	6	6
105	R:R:D124	R:R:Y135	5.75	No	Yes	0	9	8
106	R:R:R125	R:R:Y208	6.17	No	Yes	4	9	9
107	R:R:R125	R:R:Y324	4.12	No	Yes	4	9	9
108	R:R:Y126	R:R:Y127	2.98	Yes	Yes	0	9	5
109	R:R:L130	R:R:Y126	7.03	Yes	Yes	0	6	9
110	R:R:C207	R:R:Y126	4.03	No	Yes	0	6	9
111	R:R:F210	R:R:Y126	4.13	No	Yes	0	6	9
112	R:R:Y127	R:R:Y131	2.98	Yes	No	0	5	6
113	R:R:K138	R:R:Y127	3.58	No	Yes	0	5	5
114	R:R:I139	R:R:Y127	2.42	No	Yes	0	6	5
115	R:R:A128	R:R:Y135	4	No	Yes	0	8	8
116	R:R:L130	R:R:V129	2.98	Yes	No	0	6	9
117	R:R:M137	R:R:V134	3.04	No	No	0	5	5
118	R:R:K138	R:R:V134	3.04	No	No	0	5	5
119	R:R:P136	R:R:Y135	4.17	No	Yes	0	5	8
120	R:R:I139	R:R:Y135	3.63	No	Yes	0	6	8
121	R:R:G141	R:R:T140	3.64	No	No	0	4	8
122	R:R:R143	R:R:T140	3.88	No	No	0	6	8
123	R:R:H154	R:R:Y150	6.53	No	No	0	4	2
124	R:R:H154	R:R:W195	27.51	No	Yes	0	4	4
125	R:R:I157	R:R:W195	5.87	No	Yes	0	4	4
126	R:R:G158	R:R:W195	4.22	No	Yes	0	6	4
127	R:R:P161	R:R:P162	5.84	Yes	No	9	6	7
128	R:R:P161	R:R:W166	2.7	Yes	No	0	6	6
129	R:R:P161	R:R:Y188	6.95	Yes	Yes	9	6	8
130	R:R:P162	R:R:Y188	13.91	No	Yes	9	7	8
131	R:R:F164	R:R:L163	4.87	No	No	0	5	6
132	R:R:E185	R:R:S167	8.62	No	No	0	5	5
133	R:R:S167	R:R:Y188	5.09	No	Yes	0	5	8
134	R:R:R184	R:R:S168	6.59	Yes	No	0	3	3
135	R:R:E185	R:R:S168	7.19	No	No	0	5	3
136	R:R:A181	R:R:E170	4.53	No	No	10	4	2
137	R:R:E170	R:R:R184	8.14	No	Yes	10	2	3
138	R:R:D172	R:R:K175	16.59	No	Yes	3	3	2
139	R:R:D172	R:R:K298	8.3	No	No	3	3	1
140	R:R:D172	R:R:E306	3.9	No	Yes	3	3	5
141	R:R:E173	R:R:F174	19.82	No	No	0	1	2
142	R:R:F174	R:R:P303	11.56	No	No	0	2	3
143	R:R:E306	R:R:F174	4.66	Yes	No	0	5	2
144	R:R:E293	R:R:K175	6.75	Yes	Yes	3	4	2
145	R:R:E306	R:R:K175	13.5	Yes	Yes	3	5	2
146	R:R:K175	R:R:T310	9.01	Yes	No	0	2	6
147	R:R:T307	R:R:W176	3.64	No	No	0	5	3
148	R:R:F314	R:R:M177	3.73	Yes	No	0	7	3
149	R:R:V179	R:R:W182	4.9	No	Yes	0	3	5
150	R:R:A180	R:R:W182	6.48	No	Yes	0	6	5
151	R:R:A181	R:R:R184	2.77	No	Yes	10	4	3
152	R:R:T189	R:R:W182	9.7	No	Yes	2	6	5
153	R:R:W182	R:R:W192	2.81	Yes	Yes	0	5	6
154	R:R:W182	R:R:Y286	2.89	Yes	Yes	2	5	7
155	R:R:I290	R:R:W182	14.09	Yes	Yes	2	7	5
156	R:R:H183	R:R:R184	6.77	No	Yes	0	6	3
157	R:R:F191	R:R:Y188	3.09	No	Yes	0	4	8
158	R:R:W192	R:R:Y188	8.68	Yes	Yes	0	6	8
159	R:R:I290	R:R:T189	4.56	Yes	No	2	7	6
160	R:R:A294	R:R:T189	5.03	No	No	0	6	6
161	R:R:F191	R:R:W195	6.01	No	Yes	0	4	4
162	R:R:C196	R:R:W192	9.14	No	Yes	0	7	6
163	R:R:M287	R:R:Q193	9.52	No	No	0	7	6
164	R:R:I290	R:R:Q193	2.74	Yes	No	0	7	6
165	R:R:C196	R:R:W195	2.61	No	Yes	0	7	4
166	R:R:L198	R:R:L202	2.77	No	No	0	5	4
167	R:R:F199	R:R:P200	4.33	No	No	0	5	9
168	R:R:F199	R:R:V203	3.93	No	No	0	5	6
169	R:R:F201	R:R:F279	6.43	No	No	0	6	9
170	R:R:M204	R:R:Y208	3.59	Yes	Yes	4	8	9
171	R:R:F210	R:R:V206	2.62	No	No	0	6	3
172	R:R:I272	R:R:Y208	2.42	No	Yes	0	8	9
173	R:R:V275	R:R:Y208	3.79	No	Yes	0	8	9
174	R:R:F210	R:R:R213	5.34	No	No	0	6	4
175	R:R:F212	R:R:L269	3.65	Yes	No	0	6	7
176	R:R:F212	R:R:I272	3.77	Yes	No	0	6	8
177	R:R:R220	R:R:V217	2.62	No	No	0	5	5
178	R:R:L269	R:R:L273	6.92	No	No	0	7	6
179	R:R:T271	R:R:W327	7.28	No	No	0	9	7
180	R:R:T282	R:R:W283	3.64	No	Yes	2	8	8
181	R:R:S316	R:R:T282	7.99	No	No	2	9	8
182	R:R:W283	R:R:Y286	2.89	Yes	Yes	2	8	7
183	R:R:S313	R:R:W283	4.94	No	Yes	2	7	8
184	R:R:S316	R:R:W283	11.12	No	Yes	2	9	8
185	R:R:G284	R:R:P285	4.06	No	No	0	6	9
186	R:R:I290	R:R:Y286	10.88	Yes	Yes	2	7	7
187	R:R:T310	R:R:Y286	4.99	No	Yes	0	6	7
188	R:R:E293	R:R:V289	4.28	Yes	No	0	4	5
189	R:R:A309	R:R:V289	3.39	No	No	0	6	5
190	R:R:S292	R:R:W296	2.47	No	No	3	5	3
191	R:R:S292	R:R:S300	3.26	No	No	3	5	3
192	R:R:E293	R:R:K298	8.1	Yes	No	3	4	1
193	R:R:E293	R:R:V301	4.28	Yes	No	0	4	4
194	R:R:E293	R:R:E306	5.07	Yes	Yes	3	4	5
195	R:R:L295	R:R:W296	9.11	No	No	0	5	3
196	R:R:S300	R:R:W296	3.71	No	No	3	3	3
197	R:R:E306	R:R:K298	9.45	Yes	No	3	5	1
198	R:R:P303	R:R:S302	5.34	No	No	0	3	4
199	R:R:S302	R:R:S304	3.26	No	No	0	4	1
200	R:R:L305	R:R:S302	3	No	No	0	4	4
201	R:R:T307	R:R:W311	7.28	No	Yes	6	5	7
202	R:R:T310	R:R:W311	2.43	No	Yes	0	6	7
203	R:R:F314	R:R:S313	2.64	Yes	No	2	7	7
204	R:R:I323	R:R:Y324	7.25	No	Yes	0	8	9
205	R:R:L326	R:R:L335	2.77	No	Yes	0	6	7
206	R:R:N328	R:R:T330	7.31	No	No	1	9	7
207	R:R:N328	R:R:V331	7.39	No	No	1	9	8
208	R:R:K329	R:R:R332	2.48	No	No	0	6	9
209	R:R:T330	R:R:V331	3.17	No	No	1	7	8
210	R:R:L336	R:R:R332	2.43	No	No	0	5	9
211	R:R:C339	R:R:L335	3.17	No	Yes	0	9	7
212	R:R:L109	R:R:W152	2.28	No	No	0	6	9
213	R:R:F102	R:R:W99	2	No	No	0	4	5
214	R:R:A122	R:R:G119	1.95	No	No	0	9	6
215	R:R:A144	R:R:G141	1.95	No	No	0	7	4
216	R:R:A309	R:R:P285	1.87	No	No	0	6	9
217	R:R:G277	R:R:V281	1.84	No	No	0	6	5
218	R:R:A278	R:R:C319	1.81	No	No	0	6	6
219	R:R:A215	R:R:A268	1.79	No	No	0	8	8
220	R:R:G325	R:R:I48	1.76	No	No	0	7	8
221	R:R:G277	R:R:M280	1.75	No	No	0	6	5
222	R:R:G44	R:R:L43	1.71	No	No	0	8	4
223	R:R:C100	R:R:V169	1.71	No	No	0	9	4
224	R:R:A104	R:R:V169	1.7	No	No	0	5	4
225	R:R:C319	R:R:T282	1.69	No	No	0	6	8
226	R:R:L81	R:R:P82	1.64	No	No	0	8	8
227	R:R:L105	R:R:P162	1.64	No	No	0	7	7
228	R:R:L160	R:R:P161	1.64	No	Yes	0	5	6
229	R:R:L312	R:R:P285	1.64	No	No	0	7	9
230	R:R:S77	R:R:V41	1.62	No	Yes	0	6	7
231	R:R:A197	R:R:M115	1.61	No	No	0	8	8
232	R:R:A197	R:R:M287	1.61	No	No	0	8	7
233	R:R:V318	R:R:V41	1.6	No	Yes	0	6	7
234	R:R:V49	R:R:V50	1.6	No	No	0	7	4
235	R:R:V145	R:R:V149	1.6	No	No	0	4	3
236	R:R:C159	R:R:L108	1.59	No	No	0	8	6
237	R:R:C159	R:R:L109	1.59	No	No	0	8	6
238	R:R:A315	R:R:L312	1.58	No	No	0	4	7
239	R:R:E185	R:R:P186	1.57	No	No	0	5	4
240	R:R:I37	R:R:V41	1.54	No	Yes	0	8	7
241	R:R:I270	R:R:V274	1.54	No	No	0	7	7
242	R:R:K54	R:R:V50	1.52	No	No	0	5	4
243	R:R:A291	R:R:Q193	1.52	No	No	0	5	6
244	R:R:K218	R:R:V214	1.52	No	No	0	7	6
245	R:R:F95	R:R:G96	1.51	Yes	No	0	6	7
246	R:R:F164	R:R:G165	1.51	No	No	0	5	5
247	R:R:F212	R:R:G209	1.51	Yes	No	0	6	2
248	R:R:K267	R:R:T271	1.5	No	No	0	8	9
249	R:R:L71	R:R:V49	1.49	No	No	0	5	7
250	R:R:L52	R:R:V331	1.49	Yes	No	1	7	8
251	R:R:L79	R:R:V78	1.49	No	No	0	5	4
252	R:R:L79	R:R:V80	1.49	No	Yes	8	5	7
253	R:R:L106	R:R:V80	1.49	No	Yes	8	5	7
254	R:R:L130	R:R:V214	1.49	Yes	No	0	6	6
255	R:R:L153	R:R:V149	1.49	No	No	0	3	3
256	R:R:N101	R:R:V97	1.48	No	No	0	6	3
257	R:R:I35	R:R:I39	1.47	No	No	0	4	5
258	R:R:D124	R:R:S62	1.47	No	No	0	9	8
259	R:R:N142	R:R:T140	1.46	No	No	0	5	8
260	R:R:E293	R:R:S292	1.44	Yes	No	3	4	5
261	R:R:I211	R:R:L130	1.43	No	Yes	0	9	6
262	R:R:K64	R:R:L59	1.41	No	No	0	5	8
263	R:R:K64	R:R:L148	1.41	No	No	0	5	7
264	R:R:L276	R:R:M204	1.41	No	Yes	0	8	8
265	R:R:A147	R:R:F65	1.39	No	Yes	0	6	8
266	R:R:P132	R:R:Y131	1.39	No	No	0	9	6
267	R:R:L52	R:R:L58	1.38	Yes	Yes	1	7	8
268	R:R:L109	R:R:L156	1.38	No	No	0	6	4
269	R:R:L205	R:R:L276	1.38	No	No	0	5	8
270	R:R:L322	R:R:L326	1.38	No	No	0	6	6
271	R:R:E92	R:R:I94	1.37	No	No	0	4	3
272	R:R:I89	R:R:R90	1.25	No	No	0	4	4
273	R:R:V274	R:R:W327	1.23	No	No	0	7	7
274	R:R:V275	R:R:W327	1.23	No	No	0	8	7
275	R:R:F201	R:R:L202	1.22	No	No	0	6	4
276	R:R:F102	R:R:N101	1.21	No	No	0	4	6
277	R:R:F212	R:R:R216	1.07	Yes	No	0	6	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V41	2.0375	4	0	7
2	R:R:L52	3.015	4	1	7
3	R:R:L58	4.39	4	1	8
4	R:R:F65	3.5025	4	0	8
5	R:R:L69	4.47	4	7	9
6	R:R:N73	4.094	5	7	9
7	R:R:V80	2.7025	4	8	7
8	R:R:W93	6.9	5	5	8
9	R:R:F95	8.818	5	5	6
10	R:R:Y107	4.64	4	2	8
11	R:R:L118	4.36	4	0	9
12	R:R:I121	3.235	4	4	9
13	R:R:Y126	4.5425	4	0	9
14	R:R:Y127	2.876	5	0	5
15	R:R:L130	3.2325	4	0	6
16	R:R:Y135	4.3875	4	0	8
17	R:R:P161	4.2825	4	9	6
18	R:R:K175	11.4625	4	3	2
19	R:R:W182	6.81167	6	2	5
20	R:R:R184	6.0675	4	10	3
21	R:R:Y188	7.544	5	9	8
22	R:R:W192	6.0125	4	0	6
23	R:R:W195	9.244	5	0	4
24	R:R:M204	2.7625	4	4	8
25	R:R:Y208	4.262	5	4	9
26	R:R:F212	2.5	4	0	6
27	R:R:W283	5.36333	6	2	8
28	R:R:Y286	4.926	5	2	7
29	R:R:I290	8.0675	4	2	7
30	R:R:E293	4.98667	6	3	4
31	R:R:E306	7.316	5	3	5
32	R:R:W311	5.684	5	6	7
33	R:R:F314	4.7575	4	2	7
34	R:R:Y324	4.91	5	4	9
35	R:R:L335	3.7075	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F31	R:R:V85	10.1828	2.62	No	No	0	4	5
2	R:R:I34	R:R:V85	11.9629	3.07	No	No	0	7	5
3	R:R:I34	R:R:W311	54.9143	11.74	No	Yes	0	7	7
4	R:R:I89	R:R:S88	40.9513	3.1	No	No	0	4	5
5	R:R:I34	R:R:S88	41.6403	3.1	No	No	0	7	5
6	R:R:A317	R:R:V41	24.8062	3.39	No	Yes	0	9	7
7	R:R:A317	R:R:N73	26.7777	4.69	No	Yes	0	9	9
8	R:R:L69	R:R:N73	41.4298	2.75	Yes	Yes	7	9	9
9	R:R:H320	R:R:L69	27.5337	7.71	No	Yes	0	9	9
10	R:R:H320	R:R:L118	28.4525	5.14	No	Yes	0	9	9
11	R:R:F279	R:R:L118	83.319	2.44	No	Yes	0	9	9
12	R:R:F279	R:R:M115	86.1135	6.22	No	No	0	9	8
13	R:R:M115	R:R:W283	85.4914	4.65	No	Yes	0	8	8
14	R:R:W283	R:R:Y286	83.2998	2.89	Yes	Yes	2	8	7
15	R:R:T310	R:R:Y286	100	4.99	No	Yes	0	6	7
16	R:R:T310	R:R:W311	66.5231	2.43	No	Yes	0	6	7
17	R:R:Y107	R:R:Y286	12.6232	2.98	Yes	Yes	2	8	7
18	R:R:C42	R:R:S77	11.1972	3.44	No	No	0	6	6
19	R:R:S77	R:R:V41	15.2838	1.62	No	Yes	0	6	7
20	R:R:N45	R:R:N73	11.8097	4.09	No	Yes	0	9	9
21	R:R:L118	R:R:Y324	37.0466	7.03	Yes	Yes	0	9	9
22	R:R:I121	R:R:Y324	31.9552	3.63	Yes	Yes	4	9	9
23	R:R:F65	R:R:I121	40.712	2.51	Yes	Yes	0	8	9
24	R:R:F65	R:R:L148	35.745	4.87	Yes	No	0	8	7
25	R:R:K64	R:R:L148	31.4001	1.41	No	No	0	5	7
26	R:R:K64	R:R:L59	29.1415	1.41	No	No	0	5	8
27	R:R:L52	R:R:L59	18.6525	5.54	Yes	No	1	7	8
28	R:R:L52	R:R:L58	10.2594	1.38	Yes	Yes	1	7	8
29	R:R:I139	R:R:Y135	16.1451	3.63	No	Yes	0	6	8
30	R:R:I139	R:R:Y127	30.9982	2.42	No	Yes	0	6	5
31	R:R:I123	R:R:Y127	62.1878	2.42	No	Yes	0	6	5
32	R:R:I123	R:R:V203	64.0157	3.07	No	No	0	6	6
33	R:R:F199	R:R:V203	65.8245	3.93	No	No	0	5	6
34	R:R:F199	R:R:P200	67.6141	4.33	No	No	0	5	9
35	R:R:L116	R:R:P200	69.3846	4.93	No	No	0	6	9
36	R:R:H154	R:R:L116	71.136	9	No	No	0	4	6
37	R:R:H154	R:R:W195	74.5622	27.51	No	Yes	0	4	4
38	R:R:C196	R:R:W195	72.9639	2.61	No	Yes	0	7	4
39	R:R:C196	R:R:W192	56.1776	9.14	No	Yes	0	7	6
40	R:R:W182	R:R:W192	88.6209	2.81	Yes	Yes	0	5	6
41	R:R:W182	R:R:Y286	86.5346	2.89	Yes	Yes	2	5	7
42	R:R:L69	R:R:T117	20.088	4.42	Yes	No	0	9	8
43	R:R:I121	R:R:T117	17.9347	3.04	Yes	No	0	9	8
44	R:R:L108	R:R:W192	19.2937	3.42	No	Yes	0	6	6
45	R:R:C159	R:R:L108	18.3175	1.59	No	No	0	8	6
46	R:R:C159	R:R:L109	17.7433	1.59	No	No	0	8	6
47	R:R:L109	R:R:W152	16.7289	2.28	No	No	0	6	9
48	R:R:S72	R:R:W152	39.3818	2.47	No	No	0	8	9
49	R:R:I110	R:R:S72	13.9056	3.1	No	No	0	7	8
50	R:R:I110	R:R:L76	11.6758	9.99	No	No	0	7	7
51	R:R:F95	R:R:I94	34.1372	10.05	Yes	No	0	6	3
52	R:R:I94	R:R:R90	38.0611	5.01	No	No	0	3	4
53	R:R:I89	R:R:R90	39.9943	1.25	No	No	0	4	4
54	R:R:F95	R:R:W93	25.9451	14.03	Yes	Yes	5	6	8
55	R:R:C100	R:R:W93	17.5998	2.61	No	Yes	5	9	8
56	R:R:N101	R:R:V169	11.1877	2.96	No	No	0	6	4
57	R:R:C100	R:R:V169	15.5326	1.71	No	No	0	9	4
58	R:R:P162	R:R:Y188	10.6996	13.91	No	Yes	9	7	8
59	R:R:W192	R:R:Y188	30.7589	8.68	Yes	Yes	0	6	8
60	R:R:C196	R:R:S112	25.1699	3.44	No	No	0	7	7
61	R:R:S112	R:R:S155	24.3851	6.52	No	No	0	7	8
62	R:R:A113	R:R:S155	23.8492	3.42	No	No	0	8	8
63	R:R:L118	R:R:M204	32.9218	2.83	Yes	Yes	0	9	8
64	R:R:M204	R:R:Y208	23.9353	3.59	Yes	Yes	4	8	9
65	R:R:Y126	R:R:Y127	22.4232	2.98	Yes	Yes	0	9	5
66	R:R:L130	R:R:Y126	11.2929	7.03	Yes	Yes	0	6	9
67	R:R:A144	R:R:L61	11.5609	3.15	No	No	0	7	5
68	R:R:I139	R:R:L61	13.6377	4.28	No	No	0	6	5
69	R:R:E185	R:R:S167	15.4656	8.62	No	No	0	5	5
70	R:R:S167	R:R:Y188	17.5998	5.09	No	Yes	0	5	8
71	R:R:E185	R:R:S168	11.1398	7.19	No	No	0	5	3
72	R:R:K175	R:R:T310	48.2247	9.01	Yes	No	0	2	6
73	R:R:E293	R:R:K175	26.548	6.75	Yes	Yes	3	4	2
74	R:R:E306	R:R:K175	16.3748	13.5	Yes	Yes	3	5	2
75	R:R:E306	R:R:F174	13.14	4.66	Yes	No	0	5	2
76	R:R:F212	R:R:I272	12.6519	3.77	Yes	No	0	6	8
77	R:R:I272	R:R:Y208	14.834	2.42	No	Yes	0	8	9
78	R:R:A309	R:R:V289	11.092	3.39	No	No	0	6	5
79	R:R:E293	R:R:V289	13.2549	4.28	Yes	No	0	4	5
80	R:R:V275	R:R:W327	12.049	1.23	No	No	0	8	7
81	R:R:V275	R:R:Y208	14.2406	3.79	No	Yes	0	8	9
82	R:R:N73	R:R:S72	34.7306	2.98	Yes	No	0	9	8
83	R:R:A113	R:R:W152	23.3707	7.78	No	No	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8SMV_nogp

PDB Summary
PDB	8SMV_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.42
Number of Linked Nodes	248
Number of Links	277
Number of Hubs	35
Number of Links mediated by Hubs	135
Number of Communities	10
Number of Nodes involved in Communities	54
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	28402
Length Of Smallest Path	3
Average Path Length	13.6932
Length of Longest Path	32
Minimum Path Strength	1.29
Average Path Strength	4.9453
Maximum Path Strength	18.255
Minimum Path Correlation	0.7
Average Path Correlation	0.915761
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	44.0761
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	39.1008
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • negative regulation of signaling • regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning • chordate embryonic development • negative regulation of biological process • pattern specification process • regulation of signal transduction • embryo development • negative regulation of cell communication • multicellular organism development • embryo development ending in birth or egg hatching • dorsal/ventral neural tube patterning • negative regulation of smoothened signaling pathway • negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning • anatomical structure development • negative regulation of cellular process • smoothened signaling pathway involved in dorsal/ventral neural tube patterning • regulation of smoothened signaling pathway • system development • developmental process • epithelium development • regulation of signaling • neural tube development • cell surface receptor signaling pathway • tube development • negative regulation of response to stimulus • nervous system development • tissue development • negative regulation of signal transduction • regionalization • smoothened signaling pathway • dorsal/ventral pattern formation • regulation of response to stimulus • neural tube patterning • regulation of cell communication • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • cytoplasm • vesicle • organelle membrane • endocytic vesicle • endosome • recycling endosome • endomembrane system • plasma membrane • ciliary membrane • cell periphery • plasma membrane region • cell projection membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8N6U8
Sequence	>8SMV_nogp_Chain_R I T Q F I A I I V I T I F V C L G N L V I V V T L Y K K S Y L L T L S N K F V F S L T L S N F L L S V L V L P F V V T S S I R R E W I F G V V W C N F S A L L Y L L I S S A S M L T L G V I A I D R Y Y A V L Y P M V Y P M K I T G N R A V M A L V Y I W L H S L I G C L P P L F G W S S V E F D E F K W M C V A A W H R E P G Y T A F W Q I W C A L F P F L V M L V C Y G F I F R V A R V K A R C K A L I T I L V V L G A F M V T W G P Y M V V I A S E A L W G K S S V S P S L E T W A T W L S F A S A V C H P L I Y G L W N K T V R K E L L G M C F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8SMV	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	2.74	2024-02-21	doi.org/10.1038/s41594-024-01223-8
	8SMV (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		2.74	2024-02-21	doi.org/10.1038/s41594-024-01223-8

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

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You can also read or download a guide explaining the meaning of all files and numerical data.