psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I27	R:R:T29	9.12	No	No	0	2	3
2	R:R:I27	R:R:Q30	12.35	No	Yes	0	2	4
3	R:R:Q30	R:R:T307	15.59	Yes	No	0	4	5
4	R:R:Q30	R:R:W308	5.48	Yes	No	0	4	5
5	R:R:F31	R:R:I35	15.07	No	No	6	4	4
6	R:R:F31	R:R:V85	5.24	No	No	6	4	5
7	R:R:F31	R:R:I89	15.07	No	No	0	4	4
8	R:R:I34	R:R:W311	14.09	Yes	No	0	7	7
9	R:R:F314	R:R:I34	3.77	Yes	Yes	0	7	7
10	R:R:I35	R:R:V85	6.14	No	No	6	4	5
11	R:R:F40	R:R:V36	5.24	No	No	0	4	4
12	R:R:A315	R:R:I37	4.87	No	No	0	4	8
13	R:R:L81	R:R:T38	10.32	Yes	No	0	8	6
14	R:R:F40	R:R:V318	7.87	No	No	0	4	6
15	R:R:L81	R:R:V41	4.47	Yes	Yes	0	8	7
16	R:R:A317	R:R:V41	5.09	No	Yes	0	9	7
17	R:R:C42	R:R:S77	5.16	No	No	0	6	6
18	R:R:G44	R:R:L43	5.13	No	No	0	8	4
19	R:R:N45	R:R:T70	4.39	No	No	0	9	9
20	R:R:N45	R:R:N73	10.9	No	No	0	9	9
21	R:R:N45	R:R:P321	14.66	No	No	0	9	9
22	R:R:L46	R:R:V50	5.96	No	No	0	4	4
23	R:R:F74	R:R:L46	9.74	No	No	0	7	4
24	R:R:L335	R:R:V47	4.47	No	No	0	7	7
25	R:R:I48	R:R:T70	10.64	No	No	0	8	9
26	R:R:F67	R:R:V49	5.24	No	No	0	6	7
27	R:R:T70	R:R:V49	4.76	No	No	0	9	7
28	R:R:L71	R:R:V49	4.47	No	No	0	5	7
29	R:R:E334	R:R:T51	5.64	Yes	No	0	7	8
30	R:R:L335	R:R:T51	7.37	No	No	0	7	8
31	R:R:M338	R:R:T51	6.02	No	No	0	5	8
32	R:R:L52	R:R:L59	4.15	No	No	0	7	8
33	R:R:L52	R:R:N63	4.12	No	Yes	0	7	9
34	R:R:F67	R:R:L52	6.09	No	No	0	6	7
35	R:R:K55	R:R:Y57	14.33	No	No	5	6	5
36	R:R:E334	R:R:K55	24.3	Yes	No	5	7	6
37	R:R:K55	R:R:M338	5.76	No	No	0	6	5
38	R:R:L58	R:R:Y57	8.21	No	No	5	8	5
39	R:R:E334	R:R:Y57	5.61	Yes	No	5	7	5
40	R:R:L58	R:R:T330	5.9	No	No	0	8	7
41	R:R:E334	R:R:L58	11.93	Yes	No	5	7	8
42	R:R:K64	R:R:L59	5.64	No	No	0	5	8
43	R:R:N63	R:R:T60	4.39	Yes	No	0	9	7
44	R:R:G141	R:R:L61	5.13	No	No	0	4	5
45	R:R:A144	R:R:L61	6.3	No	No	0	7	5
46	R:R:N328	R:R:N63	4.09	No	Yes	7	9	9
47	R:R:N63	R:R:V331	7.39	Yes	No	7	9	8
48	R:R:F65	R:R:V120	7.87	No	No	0	8	6
49	R:R:F65	R:R:L148	4.87	No	No	0	8	7
50	R:R:L148	R:R:S68	7.51	No	No	0	7	9
51	R:R:S68	R:R:W152	4.94	No	Yes	0	9	9
52	R:R:L69	R:R:T117	10.32	No	No	0	9	8
53	R:R:H320	R:R:L69	3.86	Yes	No	0	9	9
54	R:R:I110	R:R:S72	4.64	No	No	0	7	8
55	R:R:S72	R:R:W152	4.94	No	Yes	0	8	9
56	R:R:N73	R:R:S114	10.43	No	No	0	9	9
57	R:R:A317	R:R:N73	4.69	No	No	0	9	9
58	R:R:F74	R:R:V78	5.24	No	No	0	7	4
59	R:R:L76	R:R:V80	7.45	No	No	0	7	7
60	R:R:I110	R:R:L76	12.85	No	No	0	7	7
61	R:R:L106	R:R:L79	4.15	No	No	0	5	5
62	R:R:F314	R:R:L81	12.18	Yes	Yes	0	7	8
63	R:R:F83	R:R:F95	11.79	No	Yes	3	5	6
64	R:R:F83	R:R:W99	16.04	No	Yes	3	5	5
65	R:R:M177	R:R:V84	10.65	No	No	0	3	7
66	R:R:F314	R:R:V84	3.93	Yes	No	0	7	7
67	R:R:F95	R:R:T86	9.08	Yes	No	0	6	5
68	R:R:S87	R:R:W93	7.41	No	Yes	3	5	8
69	R:R:F171	R:R:S87	6.61	No	No	3	3	5
70	R:R:S88	R:R:W176	9.88	No	Yes	0	5	3
71	R:R:I94	R:R:R90	6.26	No	No	0	3	4
72	R:R:R91	R:R:W176	4	No	Yes	0	3	3
73	R:R:F95	R:R:W93	19.04	Yes	Yes	3	6	8
74	R:R:C100	R:R:W93	9.14	No	Yes	3	9	8
75	R:R:F171	R:R:W93	6.01	No	Yes	3	3	8
76	R:R:C178	R:R:W93	9.14	No	Yes	3	9	8
77	R:R:F95	R:R:I94	11.3	Yes	No	0	6	3
78	R:R:F95	R:R:W99	6.01	Yes	Yes	3	6	5
79	R:R:F102	R:R:V98	3.93	No	No	0	4	3
80	R:R:F102	R:R:W99	7.02	No	Yes	0	4	5
81	R:R:S103	R:R:W99	9.88	No	Yes	0	5	5
82	R:R:C100	R:R:C178	7.28	No	No	3	9	9
83	R:R:N101	R:R:V169	4.43	No	No	0	6	4
84	R:R:A104	R:R:V169	5.09	No	No	0	5	4
85	R:R:L105	R:R:L163	4.15	No	No	0	7	6
86	R:R:S111	R:R:Y107	6.36	No	Yes	0	6	8
87	R:R:M177	R:R:Y107	5.99	No	Yes	1	3	8
88	R:R:V179	R:R:Y107	5.05	No	Yes	1	3	8
89	R:R:Y107	R:R:Y286	5.96	Yes	Yes	1	8	7
90	R:R:F314	R:R:Y107	7.22	Yes	Yes	0	7	8
91	R:R:L108	R:R:W192	5.69	No	Yes	0	6	6
92	R:R:L109	R:R:W152	6.83	No	Yes	0	6	9
93	R:R:C159	R:R:L109	4.76	No	No	0	8	6
94	R:R:S111	R:R:W283	4.94	No	Yes	0	6	8
95	R:R:C196	R:R:S112	6.89	No	No	0	7	7
96	R:R:A113	R:R:W152	7.78	No	Yes	0	8	9
97	R:R:F279	R:R:M115	8.71	Yes	No	2	9	8
98	R:R:M115	R:R:W283	22.1	No	Yes	2	8	8
99	R:R:H154	R:R:L116	10.29	No	No	0	4	6
100	R:R:L116	R:R:P200	6.57	No	No	0	6	9
101	R:R:I151	R:R:T117	6.08	No	No	0	6	8
102	R:R:L118	R:R:M204	4.24	Yes	No	2	9	8
103	R:R:F279	R:R:L118	4.87	Yes	Yes	2	9	9
104	R:R:H320	R:R:L118	14.14	Yes	Yes	2	9	9
105	R:R:L118	R:R:Y324	5.86	Yes	Yes	2	9	9
106	R:R:I151	R:R:V120	7.68	No	No	0	6	6
107	R:R:I121	R:R:R125	5.01	No	No	2	9	9
108	R:R:I121	R:R:Y324	9.67	No	Yes	2	9	9
109	R:R:A122	R:R:Y208	4	No	Yes	0	9	9
110	R:R:D124	R:R:Y135	9.2	No	Yes	0	9	8
111	R:R:R125	R:R:Y208	10.29	No	Yes	2	9	9
112	R:R:R125	R:R:Y324	6.17	No	Yes	2	9	9
113	R:R:Y126	R:R:Y127	6.95	Yes	Yes	4	9	5
114	R:R:L130	R:R:Y126	7.03	Yes	Yes	4	6	9
115	R:R:Y126	R:R:Y131	5.96	Yes	Yes	4	9	6
116	R:R:C207	R:R:Y126	4.03	No	Yes	0	6	9
117	R:R:Y127	R:R:Y131	3.97	Yes	Yes	4	5	6
118	R:R:K138	R:R:Y127	4.78	No	Yes	4	5	5
119	R:R:I139	R:R:Y127	8.46	Yes	Yes	0	6	5
120	R:R:A128	R:R:Y135	8.01	No	Yes	0	8	8
121	R:R:I211	R:R:V129	6.14	No	No	0	9	9
122	R:R:L130	R:R:Y131	5.86	Yes	Yes	4	6	6
123	R:R:K138	R:R:Y131	7.17	No	Yes	4	5	6
124	R:R:K138	R:R:V134	7.59	No	No	0	5	5
125	R:R:P136	R:R:Y135	4.17	No	Yes	0	5	8
126	R:R:I139	R:R:Y135	4.84	Yes	Yes	0	6	8
127	R:R:H154	R:R:Y150	6.53	No	No	0	4	2
128	R:R:H154	R:R:W195	32.8	No	Yes	0	4	4
129	R:R:I157	R:R:W195	4.7	No	Yes	0	4	4
130	R:R:L160	R:R:P161	4.93	No	Yes	0	5	6
131	R:R:P161	R:R:P162	5.84	Yes	No	1	6	7
132	R:R:P161	R:R:W166	9.46	Yes	No	0	6	6
133	R:R:P161	R:R:Y188	5.56	Yes	Yes	1	6	8
134	R:R:P162	R:R:Y188	6.95	No	Yes	1	7	8
135	R:R:E185	R:R:S167	5.75	No	No	0	5	5
136	R:R:A181	R:R:E170	4.53	No	No	8	4	2
137	R:R:E170	R:R:R184	8.14	No	Yes	8	2	3
138	R:R:F171	R:R:W176	5.01	No	Yes	0	3	3
139	R:R:D172	R:R:K175	15.21	No	Yes	0	3	2
140	R:R:D172	R:R:H183	5.04	No	No	0	3	6
141	R:R:D172	R:R:K298	5.53	No	No	0	3	1
142	R:R:F174	R:R:P303	18.78	No	No	0	2	3
143	R:R:E306	R:R:F174	8.16	Yes	No	0	5	2
144	R:R:K175	R:R:W182	6.96	Yes	Yes	1	2	5
145	R:R:K175	R:R:Y286	7.17	Yes	Yes	1	2	7
146	R:R:E293	R:R:K175	8.1	Yes	Yes	1	4	2
147	R:R:E306	R:R:K175	12.15	Yes	Yes	1	5	2
148	R:R:K175	R:R:T310	6.01	Yes	No	1	2	6
149	R:R:T307	R:R:W176	4.85	No	Yes	0	5	3
150	R:R:M177	R:R:V179	4.56	No	No	1	3	3
151	R:R:V179	R:R:W182	7.36	No	Yes	1	3	5
152	R:R:A181	R:R:R184	4.15	No	Yes	8	4	3
153	R:R:W182	R:R:Y188	3.86	Yes	Yes	1	5	8
154	R:R:T189	R:R:W182	12.13	No	Yes	1	6	5
155	R:R:W182	R:R:W192	6.56	Yes	Yes	1	5	6
156	R:R:W182	R:R:Y286	6.75	Yes	Yes	1	5	7
157	R:R:I290	R:R:W182	10.57	Yes	Yes	1	7	5
158	R:R:H183	R:R:R184	5.64	No	Yes	0	6	3
159	R:R:E185	R:R:G187	4.91	No	No	0	5	4
160	R:R:F191	R:R:Y188	4.13	No	Yes	0	4	8
161	R:R:I290	R:R:T189	4.56	Yes	No	1	7	6
162	R:R:A294	R:R:T189	5.03	No	No	0	6	6
163	R:R:F191	R:R:W195	8.02	No	Yes	0	4	4
164	R:R:C196	R:R:W192	3.92	No	Yes	0	7	6
165	R:R:W192	R:R:Y286	3.86	Yes	Yes	1	6	7
166	R:R:M287	R:R:Q193	8.16	Yes	No	0	7	6
167	R:R:I290	R:R:Q193	6.86	Yes	No	0	7	6
168	R:R:A291	R:R:Q193	4.55	No	No	0	5	6
169	R:R:C196	R:R:W195	3.92	No	Yes	0	7	4
170	R:R:A197	R:R:M287	4.83	No	Yes	0	8	7
171	R:R:L198	R:R:L202	5.54	No	No	0	5	4
172	R:R:F199	R:R:P200	4.33	No	No	0	5	9
173	R:R:F201	R:R:L205	7.31	Yes	No	0	6	5
174	R:R:F201	R:R:L276	4.87	Yes	No	0	6	8
175	R:R:F201	R:R:F279	10.72	Yes	Yes	0	6	9
176	R:R:F201	R:R:M280	6.22	Yes	No	0	6	5
177	R:R:F279	R:R:M204	4.98	Yes	No	2	9	8
178	R:R:F210	R:R:V206	3.93	No	No	0	6	3
179	R:R:I272	R:R:Y208	7.25	No	Yes	0	8	9
180	R:R:V275	R:R:Y208	5.05	No	Yes	0	8	9
181	R:R:Y208	R:R:Y324	4.96	Yes	Yes	2	9	9
182	R:R:F210	R:R:R213	6.41	No	No	0	6	4
183	R:R:F212	R:R:R216	11.76	Yes	No	9	6	6
184	R:R:F212	R:R:L269	7.31	Yes	No	9	6	7
185	R:R:L269	R:R:R216	6.07	No	No	9	7	6
186	R:R:T271	R:R:W327	13.34	No	No	0	9	7
187	R:R:V274	R:R:W327	4.9	No	No	0	7	7
188	R:R:F279	R:R:W283	7.02	Yes	Yes	2	9	8
189	R:R:T282	R:R:W283	4.85	No	Yes	2	8	8
190	R:R:S316	R:R:T282	4.8	No	No	2	9	8
191	R:R:M287	R:R:W283	4.65	Yes	Yes	0	7	8
192	R:R:S313	R:R:W283	8.65	No	Yes	0	7	8
193	R:R:S316	R:R:W283	14.83	No	Yes	2	9	8
194	R:R:H320	R:R:W283	4.23	Yes	Yes	2	9	8
195	R:R:G284	R:R:P285	4.06	No	No	0	6	9
196	R:R:I290	R:R:Y286	7.25	Yes	Yes	1	7	7
197	R:R:T310	R:R:Y286	4.99	No	Yes	1	6	7
198	R:R:S313	R:R:Y286	12.72	No	Yes	0	7	7
199	R:R:E293	R:R:K298	8.1	Yes	No	1	4	1
200	R:R:E293	R:R:V301	4.28	Yes	Yes	1	4	4
201	R:R:E293	R:R:E306	12.69	Yes	Yes	1	4	5
202	R:R:L295	R:R:W296	7.97	No	No	0	5	3
203	R:R:E306	R:R:K298	9.45	Yes	No	1	5	1
204	R:R:E306	R:R:V301	5.7	Yes	Yes	1	5	4
205	R:R:L305	R:R:S302	6.01	No	No	0	4	4
206	R:R:T307	R:R:W311	6.06	No	No	0	5	7
207	R:R:W308	R:R:W311	6.56	No	No	0	5	7
208	R:R:H320	R:R:S316	8.37	Yes	No	2	9	9
209	R:R:I323	R:R:Y324	6.04	No	Yes	0	8	9
210	R:R:N328	R:R:T330	4.39	No	No	0	9	7
211	R:R:N328	R:R:V331	7.39	No	No	7	9	8
212	R:R:K329	R:R:R332	7.43	No	No	0	6	9
213	R:R:I139	R:R:R143	3.76	Yes	No	0	6	6
214	R:R:G119	R:R:V203	3.68	No	No	0	6	6
215	R:R:G141	R:R:T140	3.64	No	No	0	4	8
216	R:R:L336	R:R:R332	3.64	No	No	0	5	9
217	R:R:A278	R:R:C319	3.61	No	No	0	6	6
218	R:R:P303	R:R:S302	3.56	No	No	0	3	4
219	R:R:G284	R:R:M287	3.49	No	Yes	0	6	7
220	R:R:A113	R:R:S155	3.42	No	No	0	8	8
221	R:R:C178	R:R:V169	3.42	No	No	0	9	4
222	R:R:A309	R:R:V289	3.39	No	No	0	6	5
223	R:R:C319	R:R:T282	3.38	No	No	0	6	8
224	R:R:L105	R:R:P162	3.28	No	No	0	7	7
225	R:R:L312	R:R:P285	3.28	No	No	0	7	9
226	R:R:S292	R:R:S300	3.26	No	No	1	5	3
227	R:R:S77	R:R:V41	3.23	No	Yes	0	6	7
228	R:R:S77	R:R:V78	3.23	No	No	0	6	4
229	R:R:V318	R:R:V41	3.21	No	Yes	0	6	7
230	R:R:A144	R:R:K64	3.21	No	No	0	7	5
231	R:R:V289	R:R:V301	3.21	No	Yes	0	5	4
232	R:R:I34	R:R:V85	3.07	Yes	No	0	7	5
233	R:R:I121	R:R:V66	3.07	No	No	0	9	8
234	R:R:I123	R:R:V203	3.07	No	No	0	6	6
235	R:R:K64	R:R:V145	3.04	No	No	0	5	4
236	R:R:M137	R:R:V134	3.04	No	No	0	5	5
237	R:R:F191	R:R:G158	3.01	No	No	0	4	6
238	R:R:L59	R:R:S56	3	No	No	0	8	7
239	R:R:L43	R:R:V47	2.98	No	No	0	4	7
240	R:R:L79	R:R:V78	2.98	No	No	0	5	4
241	R:R:L130	R:R:V129	2.98	Yes	No	0	6	9
242	R:R:L130	R:R:V214	2.98	Yes	No	0	6	6
243	R:R:L153	R:R:V149	2.98	No	No	0	3	3
244	R:R:N101	R:R:V97	2.96	No	No	0	6	3
245	R:R:I28	R:R:I32	2.94	No	No	0	5	3
246	R:R:I34	R:R:I37	2.94	Yes	No	0	7	8
247	R:R:D124	R:R:S62	2.94	No	No	0	9	8
248	R:R:N142	R:R:T140	2.92	No	No	0	5	8
249	R:R:Q30	R:R:S304	2.89	Yes	No	0	4	1
250	R:R:I139	R:R:L61	2.85	Yes	No	0	6	5
251	R:R:G96	R:R:W93	2.81	No	Yes	0	7	8
252	R:R:C266	R:R:R216	2.79	No	No	0	5	6
253	R:R:A147	R:R:F65	2.77	No	No	0	6	8
254	R:R:L109	R:R:L156	2.77	No	No	0	6	4
255	R:R:A268	R:R:F212	2.77	No	Yes	0	8	6
256	R:R:L322	R:R:L326	2.77	No	No	0	6	6
257	R:R:A180	R:R:Y188	2.67	No	Yes	0	6	8
258	R:R:R184	R:R:S168	2.64	Yes	No	0	3	3
259	R:R:F199	R:R:V203	2.62	No	No	0	5	6
260	R:R:A33	R:R:W308	2.59	No	No	0	4	5
261	R:R:F40	R:R:I39	2.51	No	No	0	4	5
262	R:R:S292	R:R:W296	2.47	No	No	1	5	3
263	R:R:S300	R:R:W296	2.47	No	No	1	3	3
264	R:R:E185	R:R:Y188	2.24	No	Yes	0	5	8
265	R:R:E173	R:R:W176	2.18	No	Yes	0	1	3
266	R:R:F67	R:R:Y53	2.06	No	No	0	6	4
267	R:R:A294	R:R:P186	1.87	No	No	0	6	4
268	R:R:A215	R:R:A268	1.79	No	No	0	8	8
269	R:R:G325	R:R:I48	1.76	No	No	0	7	8
270	R:R:G277	R:R:M280	1.75	No	No	0	6	5
271	R:R:G337	R:R:L336	1.71	No	No	0	3	5
272	R:R:L81	R:R:P82	1.64	Yes	No	0	8	8
273	R:R:S292	R:R:V301	1.62	No	Yes	1	5	4
274	R:R:V145	R:R:V149	1.6	No	No	0	4	3
275	R:R:V274	R:R:V275	1.6	No	No	0	7	8
276	R:R:I28	R:R:T29	1.52	No	No	0	5	3
277	R:R:K218	R:R:V214	1.52	No	No	0	7	6
278	R:R:F212	R:R:G209	1.51	Yes	No	0	6	2
279	R:R:K267	R:R:T271	1.5	No	No	0	8	9
280	R:R:L205	R:R:V206	1.49	No	No	0	5	3
281	R:R:L322	R:R:V318	1.49	No	No	0	6	6
282	R:R:I194	R:R:L198	1.43	No	No	0	3	5
283	R:R:P132	R:R:Y131	1.39	No	Yes	0	9	6
284	R:R:L75	R:R:L79	1.38	No	No	0	7	5
285	R:R:E334	R:R:K333	1.35	Yes	No	0	7	6
286	R:R:F212	R:R:I272	1.26	Yes	No	0	6	8
287	R:R:F201	R:R:L198	1.22	Yes	No	0	6	5
288	R:R:E92	R:R:R90	1.16	No	No	0	4	4
289	R:R:F164	R:R:W166	1	No	No	0	5	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Q30	9.0775	4	0	4
2	R:R:I34	5.9675	4	0	7
3	R:R:V41	4	4	0	7
4	R:R:N63	4.9975	4	7	9
5	R:R:L81	7.1525	4	0	8
6	R:R:W93	8.925	6	3	8
7	R:R:F95	11.444	5	3	6
8	R:R:W99	9.7375	4	3	5
9	R:R:Y107	6.116	5	1	8
10	R:R:L118	7.2775	4	2	9
11	R:R:Y126	5.9925	4	4	9
12	R:R:Y127	6.04	4	4	5
13	R:R:L130	4.7125	4	4	6
14	R:R:Y131	4.87	5	4	6
15	R:R:Y135	6.555	4	0	8
16	R:R:I139	4.9775	4	0	6
17	R:R:W152	6.1225	4	0	9
18	R:R:P161	6.4475	4	1	6
19	R:R:K175	9.26667	6	1	2
20	R:R:W176	5.184	5	0	3
21	R:R:W182	7.74143	7	1	5
22	R:R:R184	5.1425	4	8	3
23	R:R:Y188	4.235	6	1	8
24	R:R:W192	5.0075	4	1	6
25	R:R:W195	12.36	4	0	4
26	R:R:F201	6.068	5	0	6
27	R:R:Y208	6.31	5	2	9
28	R:R:F212	4.922	5	9	6
29	R:R:F279	7.26	5	2	9
30	R:R:W283	8.90875	8	2	8
31	R:R:Y286	6.95714	7	1	7
32	R:R:M287	5.2825	4	0	7
33	R:R:I290	7.31	4	1	7
34	R:R:E293	8.2925	4	1	4
35	R:R:V301	3.7025	4	1	4
36	R:R:E306	9.63	5	1	5
37	R:R:F314	6.775	4	0	7
38	R:R:H320	7.65	4	2	9
39	R:R:Y324	6.54	5	2	9
40	R:R:E334	9.766	5	5	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I34	R:R:W311	45.9703	14.09	Yes	No	0	7	7
2	R:R:T307	R:R:W311	35.895	6.06	No	No	0	5	7
3	R:R:F314	R:R:I34	52.5904	3.77	Yes	Yes	0	7	7
4	R:R:L81	R:R:V41	80.2618	4.47	Yes	Yes	0	8	7
5	R:R:F314	R:R:L81	82.0167	12.18	Yes	Yes	0	7	8
6	R:R:A317	R:R:V41	69.29	5.09	No	Yes	0	9	7
7	R:R:S77	R:R:V41	11.5862	3.23	No	Yes	0	6	7
8	R:R:E334	R:R:L58	12.6931	11.93	Yes	No	5	7	8
9	R:R:L58	R:R:T330	17.5666	5.9	No	No	0	8	7
10	R:R:N328	R:R:T330	18.7787	4.39	No	No	0	9	7
11	R:R:N328	R:R:N63	19.7761	4.09	No	Yes	7	9	9
12	R:R:L52	R:R:N63	23.2145	4.12	No	Yes	0	7	9
13	R:R:F67	R:R:L52	59.6734	6.09	No	No	0	6	7
14	R:R:F67	R:R:V49	61.3737	5.24	No	No	0	6	7
15	R:R:T70	R:R:V49	63.0319	4.76	No	No	0	9	7
16	R:R:N45	R:R:T70	65.4181	4.39	No	No	0	9	9
17	R:R:N45	R:R:N73	66.9921	10.9	No	No	0	9	9
18	R:R:A317	R:R:N73	68.5325	4.69	No	No	0	9	9
19	R:R:L52	R:R:L59	41.122	4.15	No	No	0	7	8
20	R:R:K64	R:R:L59	39.0598	5.64	No	No	0	5	8
21	R:R:A144	R:R:L61	33.9885	6.3	No	No	0	7	5
22	R:R:A144	R:R:K64	34.9606	3.21	No	No	0	7	5
23	R:R:F65	R:R:V120	16.5439	7.87	No	No	0	8	6
24	R:R:I151	R:R:V120	17.6718	7.68	No	No	0	6	6
25	R:R:I151	R:R:T117	18.7829	6.08	No	No	0	6	8
26	R:R:L69	R:R:T117	19.8855	10.32	No	No	0	9	8
27	R:R:H320	R:R:L69	20.9798	3.86	Yes	No	0	9	9
28	R:R:H320	R:R:W283	38.4538	4.23	Yes	Yes	2	9	8
29	R:R:S111	R:R:W283	49.7285	4.94	No	Yes	0	6	8
30	R:R:S111	R:R:Y107	50.3093	6.36	No	Yes	0	6	8
31	R:R:F314	R:R:Y107	100	7.22	Yes	Yes	0	7	8
32	R:R:F65	R:R:L148	14.2755	4.87	No	No	0	8	7
33	R:R:L148	R:R:S68	13.135	7.51	No	No	0	7	9
34	R:R:S68	R:R:W152	11.9818	4.94	No	Yes	0	9	9
35	R:R:F95	R:R:W93	12.6636	19.04	Yes	Yes	3	6	8
36	R:R:F171	R:R:W93	22.1161	6.01	No	Yes	3	3	8
37	R:R:F171	R:R:W176	24.4897	5.01	No	Yes	0	3	3
38	R:R:T307	R:R:W176	28.8245	4.85	No	Yes	0	5	3
39	R:R:V179	R:R:Y107	11.0475	5.05	No	Yes	1	3	8
40	R:R:V179	R:R:W182	11.1401	7.36	No	Yes	1	3	5
41	R:R:W182	R:R:Y188	25.4703	3.86	Yes	Yes	1	5	8
42	R:R:Y107	R:R:Y286	40.638	5.96	Yes	Yes	1	8	7
43	R:R:W182	R:R:Y286	16.2956	6.75	Yes	Yes	1	5	7
44	R:R:W192	R:R:Y286	15.3066	3.86	Yes	Yes	1	6	7
45	R:R:C196	R:R:W192	15.778	3.92	No	Yes	0	7	6
46	R:R:F279	R:R:W283	32.4608	7.02	Yes	Yes	2	9	8
47	R:R:H154	R:R:W195	12.4784	32.8	No	Yes	0	4	4
48	R:R:C196	R:R:W195	13.2444	3.92	No	Yes	0	7	4
49	R:R:F279	R:R:L118	21.4048	4.87	Yes	Yes	2	9	9
50	R:R:H320	R:R:L118	22.4991	14.14	Yes	Yes	2	9	9
51	R:R:L118	R:R:Y324	40.0025	5.86	Yes	Yes	2	9	9
52	R:R:Y208	R:R:Y324	30.306	4.96	Yes	Yes	2	9	9
53	R:R:I139	R:R:L61	29.5442	2.85	Yes	No	0	6	5
54	R:R:I139	R:R:Y127	21.792	8.46	Yes	Yes	0	6	5
55	R:R:K175	R:R:Y286	30.7437	7.17	Yes	Yes	1	2	7
56	R:R:E293	R:R:K175	11.561	8.1	Yes	Yes	1	4	2
57	R:R:E306	R:R:K175	16.7838	12.15	Yes	Yes	1	5	2
58	R:R:F201	R:R:F279	13.2823	10.72	Yes	Yes	0	6	9
59	R:R:I272	R:R:Y208	16.6323	7.25	No	Yes	0	8	9
60	R:R:V275	R:R:Y208	10.3363	5.05	No	Yes	0	8	9
61	R:R:F212	R:R:I272	14.7974	1.26	Yes	No	0	6	8
62	R:R:S313	R:R:Y286	24.254	12.72	No	Yes	0	7	7
63	R:R:S292	R:R:V301	10.8203	1.62	No	Yes	1	5	4
64	R:R:S313	R:R:W283	23.7364	8.65	No	Yes	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8KH4_nogp

PDB Summary
PDB	8KH4_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.77
Number of Linked Nodes	253
Number of Links	289
Number of Hubs	40
Number of Links mediated by Hubs	151
Number of Communities	9
Number of Nodes involved in Communities	61
Number of Links involved in Communities	83

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	45689
Length Of Smallest Path	3
Average Path Length	14.7087
Length of Longest Path	36
Minimum Path Strength	1.325
Average Path Strength	6.57567
Maximum Path Strength	21.545
Minimum Path Correlation	0.7
Average Path Correlation	0.911268
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.125
Average % Of Corr. Nodes	40.1634
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.5756
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • negative regulation of signaling • regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning • chordate embryonic development • negative regulation of biological process • pattern specification process • regulation of signal transduction • embryo development • negative regulation of cell communication • multicellular organism development • embryo development ending in birth or egg hatching • dorsal/ventral neural tube patterning • negative regulation of smoothened signaling pathway • negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning • anatomical structure development • negative regulation of cellular process • smoothened signaling pathway involved in dorsal/ventral neural tube patterning • regulation of smoothened signaling pathway • system development • developmental process • epithelium development • regulation of signaling • neural tube development • cell surface receptor signaling pathway • tube development • negative regulation of response to stimulus • nervous system development • tissue development • negative regulation of signal transduction • regionalization • smoothened signaling pathway • dorsal/ventral pattern formation • regulation of response to stimulus • neural tube patterning • regulation of cell communication • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • intracellular organelle • cytoplasmic vesicle membrane • bounding membrane of organelle • cytoplasmic vesicle • vesicle membrane • endocytic vesicle membrane • cytoplasm • vesicle • organelle membrane • endocytic vesicle • endosome • recycling endosome • endomembrane system • plasma membrane • ciliary membrane • cell periphery • plasma membrane region • cell projection membrane • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein binding • signaling receptor binding • G protein-coupled receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • D1 dopamine receptor binding • dopamine receptor binding • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase activator activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to amine • response to chemical • response to nitrogen compound • response to amphetamine • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to purine-containing compound • response to caffeine • response to alkaloid • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • cellular response to endogenous stimulus • response to hormone • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of taste • sensory organ development • eye development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8N6U8
Sequence	>8KH4_nogp_Chain_R I I T Q F I A I I V I T I F V C L G N L V I V V T L Y K K S Y L L T L S N K F V F S L T L S N F L L S V L V L P F V V T S S I R R E W I F G V V W C N F S A L L Y L L I S S A S M L T L G V I A I D R Y Y A V L Y P M V Y P M K I T G N R A V M A L V Y I W L H S L I G C L P P L F G W S S V E F D E F K W M C V A A W H R E P G Y T A F W Q I W C A L F P F L V M L V C Y G F I F R V A R V K A C K A L I T I L V V L G A F M V T W G P Y M V V I A S E A L W G K S S V S P S L E T W A T W L S F A S A V C H P L I Y G L W N K T V R K E L L G M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8KH4	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8KH4 (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		3.1	2023-10-11	doi.org/10.1038/s41467-023-41654-3
	8SMV	A	Orphan	Orphan	GPR161	Homo sapiens	-	-	Gs/β1/γ2	2.74	2024-02-21	doi.org/10.1038/s41594-024-01223-8
	8SMV (No Gprot)	A	Orphan	Orphan	GPR161	Homo sapiens	-	-		2.74	2024-02-21	doi.org/10.1038/s41594-024-01223-8

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Download 8KH4_nogp.zip

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