Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 4.662546
2A:A:N50 6.24559
3A:A:K53 5.642559
4A:A:V214 4.33446
5A:A:F219 5.33667648
6A:A:F222 4.655417
7A:A:Q227 5.584519
8A:A:K233 5.6525419
9A:A:W234 5.858519
10A:A:F238 5.68333619
11A:A:T242 3.3175408
12A:A:V247 4.25457
13A:A:D249 8.2875458
14A:A:Y253 5.6565208
15A:A:R265 7.755459
16A:A:L270 4.225406
17A:A:F273 4.145409
18A:A:W277 8.2256176
19A:A:W281 8.56833615
20A:A:V287 3.21754176
21A:A:I288 3.754539
22A:A:F290 3.712539
23A:A:K293 6.6725459
24A:A:L296 4.1975456
25A:A:L297 3.4625408
26A:A:F312 3.5556218
27A:A:F315 8.81506
28A:A:E330 6.138563
29A:A:D331 7.4375464
30A:A:V334 3.6564
31A:A:K338 8.6025465
32A:A:Y339 3.896503
33A:A:F340 9.7654217
34A:A:R342 4.944564
35A:A:E344 6.4854215
36A:A:F345 5.9025408
37A:A:Y360 5.59833638
38A:A:F363 9.045465
39A:A:T364 4.8525439
40A:A:D368 6.29439
41A:A:N371 6.23439
42A:A:R373 5.13445
43A:A:R374 5.17534
44A:A:F376 3.83648
45A:A:I383 3.565448
46A:A:H387 4.29448
47A:A:L388 3.9075408
48A:A:Y391 7.026504
49A:A:L393 2.49508
50B:B:L7 4.3585221
51B:B:L14 4.5725401
52B:B:D27 7.5575403
53B:B:L30 4.4025403
54B:B:V40 4.97254141
55B:B:R48 2.672583
56B:B:H54 7.9585119
57B:B:K57 10.16517
58B:B:Y59 7.978519
59B:B:W63 6.452506
60B:B:Q75 9.065419
61B:B:D76 6.7775409
62B:B:W82 9.9365117
63B:B:K89 4.851437117
64B:B:I93 3.62496
65B:B:L95 4.66595
66B:B:W99 5.79429718
67B:B:Y105 3.3475407
68B:B:Y111 5.83404
69B:B:C114 5.01499
70B:B:L117 3.88333619
71B:B:Y124 4.14333696
72B:B:V133 3.565493
73B:B:H142 5.94833615
74B:B:Y145 4.33571718
75B:B:F151 4.58506
76B:B:L152 4.1975409
77B:B:D163 8.7575419
78B:B:T165 3.6375416
79B:B:W169 8.01333616
80B:B:F180 7.4574
81B:B:H183 6.63571776
82B:B:L190 4.0875407
83B:B:A193 2.72415
84B:B:V200 3.8125419
85B:B:C204 4.33418
86B:B:D205 6.7477
87B:B:K209 8.8075476
88B:B:L210 3.695416
89B:B:W211 7.67833675
90B:B:R219 5.4415
91B:B:Q220 6.446515
92B:B:H225 7.71833616
93B:B:S227 4.495413
94B:B:D228 7.312516
95B:B:I232 3.63415
96B:B:F234 4.9225413
97B:B:F235 6.296676195
98B:B:P236 4.964196
99B:B:F241 5.15833616
100B:B:T243 4.12614
101B:B:S245 5.87415
102B:B:D247 7.204519
103B:B:T249 4.6625415
104B:B:R251 9.892518
105B:B:F253 5.35167617
106B:B:Y264 5.601676101
107B:B:H266 7.45254102
108B:B:I269 2.7354104
109B:B:V276 2.16408
110B:B:F278 4.50754195
111B:B:R283 5.847147149
112B:B:L284 3.9025409
113B:B:Y289 6.2625107
114B:B:D290 7.7825417
115B:B:N295 6.05754105
116B:B:W297 6.494105
117B:B:K301 4.57406
118B:B:H311 7.515125
119B:B:R314 15.6175417
120B:B:V315 2.63254128
121B:B:L318 2.956507
122B:B:W332 8.41857719
123B:B:D333 8.5354129
124B:B:K337 4.0865127
125B:B:W339 10.56754125
126G:G:I9 2.25222
127G:G:R27 4.1325408
128G:G:D48 5.29833609
129G:G:L51 4.0554146
130G:G:N59 4.4825489
131G:G:P60 6.825489
132G:G:F61 4.56875888
133R:R:V41 2.0375407
134R:R:Y57 8.354185
135R:R:F65 3.5025408
136R:R:L69 4.474279
137R:R:N73 4.0945279
138R:R:V80 2.70254287
139R:R:W93 6.95168
140R:R:F95 8.8185166
141R:R:Y107 4.64428
142R:R:M115 3.7025408
143R:R:L118 4.36409
144R:R:I121 3.2354139
145R:R:R125 5.574139
146R:R:Y126 4.5425409
147R:R:Y127 2.876505
148R:R:L130 3.445406
149R:R:M133 5.0775447
150R:R:Y135 4.3875408
151R:R:P161 4.2825426
152R:R:K175 9.648522
153R:R:W182 5.66625825
154R:R:R184 6.06754293
155R:R:Y188 7.544528
156R:R:W192 4.785626
157R:R:W195 9.244504
158R:R:M204 2.76254138
159R:R:Y208 4.2625139
160R:R:F212 2.5406
161R:R:W283 4.93728
162R:R:Y286 4.50333627
163R:R:M287 3.9475407
164R:R:I290 8.0675427
165R:R:E293 4.58571724
166R:R:E306 7.316525
167R:R:W311 5.684527
168R:R:F314 4.7575427
169R:R:Y324 4.915139
170R:R:L335 3.7075407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:M61 B:B:W63 16.65453.49NoYes076
2B:B:C317 B:B:M61 17.08484.86NoNo097
3B:B:C317 B:B:S316 17.56383.44NoNo097
4B:B:S316 B:B:W332 17.83292.47NoYes079
5B:B:W332 B:B:Y59 35.76925.79YesYes199
6A:A:C237 B:B:Y59 17.04185.38NoYes189
7A:A:C237 A:A:F238 17.49612.79NoYes189
8A:A:F238 A:A:L44 93.882214.61YesNo099
9A:A:L44 A:A:L46 93.70744.15NoNo098
10A:A:G47 A:A:L46 93.53221.71NoNo098
11A:A:G47 A:A:K53 93.35655.23NoYes099
12A:A:K53 A:A:L45 88.64427.05YesNo098
13A:A:I245 A:A:L45 86.75742.85NoNo078
14A:A:I245 A:A:I288 81.62912.94NoYes379
15A:A:A243 A:A:I288 80.56571.62NoYes089
16A:A:A243 A:A:T242 80.71961.68NoYes088
17A:A:H41 A:A:T242 79.8885.48YesYes068
18A:A:H41 A:A:I383 75.57152.65YesYes468
19B:B:M101 B:B:Y59 18.95613.59NoYes199
20B:B:M101 B:B:Y145 18.7533.59NoYes198
21A:A:F238 A:A:V224 21.90852.62YesNo199
22A:A:W234 B:B:Y145 49.06782.89YesYes198
23A:A:K233 B:B:Y145 1002.39YesYes198
24A:A:K233 B:B:D228 98.09546.91YesYes196
25A:A:R231 A:A:W234 73.4284NoYes099
26A:A:K233 B:B:M188 14.145510.08YesNo099
27A:A:W281 B:B:W332 10.18032.81YesYes159
28A:A:L272 A:A:R231 73.16393.64NoNo089
29A:A:F246 A:A:L272 72.63676.09NoNo098
30A:A:F246 A:A:V248 36.34272.62NoNo097
31A:A:F345 A:A:V248 35.76323.93YesNo087
32A:A:F273 A:A:F345 15.98047.5YesYes098
33A:A:F246 A:A:L289 36.02943.65NoNo099
34A:A:F345 A:A:L289 35.73964.87YesNo089
35A:A:F345 A:A:L270 55.50797.31YesYes086
36A:A:L270 A:A:Q267 15.90312.66YesNo064
37A:A:F312 A:A:Q267 14.65782.34YesNo084
38A:A:F312 A:A:I308 22.95792.51YesNo087
39A:A:I308 A:A:Y253 21.711910.88NoYes078
40A:A:L297 A:A:Y253 15.3523.52YesYes088
41A:A:E344 A:A:L270 36.89442.65YesYes056
42A:A:E344 A:A:F312 14.64044.66YesYes2158
43A:A:E344 A:A:F340 21.004710.49YesYes2157
44A:A:F340 A:A:Y318 15.98839.28YesNo076
45A:A:P321 A:A:Y318 10.87714.17NoNo056
46A:A:L297 A:A:V301 10.24392.98YesNo087
47A:A:H387 A:A:I383 74.80875.3YesYes488
48A:A:H387 A:A:Q390 75.04066.18YesNo084
49A:A:Q390 A:A:Y391 74.820718.04NoYes044
50A:A:Y391 R:R:R125 58.16668.23YesYes049
51B:B:I273 B:B:Y289 12.94817.25NoYes047
52B:B:G244 B:B:I273 36.55925.29NoNo084
53B:B:G244 B:B:T243 39.10223.64NoYes084
54B:B:F241 B:B:T243 30.91472.59YesYes164
55B:B:F222 B:B:F241 10.72059.65NoYes176
56B:B:F222 B:B:Q220 32.8157.03NoYes175
57B:B:D258 B:B:Q220 31.14210.44NoYes075
58B:B:D258 B:B:R22 21.56955.96NoNo074
59B:B:I18 B:B:R22 19.17463.76NoNo044
60B:B:I18 G:G:A23 16.77923.25NoNo048
61B:B:L14 G:G:A23 14.38331.58YesNo018
62B:B:F253 B:B:T243 11.97313.89YesYes174
63B:B:F222 B:B:F253 23.92777.5NoYes177
64B:B:F241 B:B:L255 14.61712.44YesNo169
65B:B:L255 B:B:Q220 10.14783.99NoYes195
66B:B:L30 B:B:M262 11.29562.83YesNo035
67B:B:S122 B:B:Y124 14.02625.09NoYes086
68B:B:E138 B:B:S122 14.38364.31NoNo058
69B:B:S97 B:B:W99 16.46942.47NoYes068
70B:B:D118 B:B:S97 16.03648.83NoNo096
71B:B:E138 B:B:I120 15.1922.73NoNo059
72B:B:D118 B:B:I120 15.60974.2NoNo099
73B:B:G162 B:B:Y145 18.06524.35NoYes198
74B:B:G162 B:B:S161 17.81083.71NoNo196
75B:B:H142 B:B:S161 15.877912.55YesNo156
76B:B:H142 B:B:W169 11.713.17YesYes156
77B:B:M188 B:B:S147 13.55653.07NoNo097
78B:B:S147 B:B:S160 13.27134.89NoNo079
79B:B:H225 B:B:T243 79.61385.48YesYes164
80B:B:D228 B:B:S227 67.27782.94YesYes163
81B:B:S227 B:B:S245 31.20013.26YesYes135
82B:B:H225 B:B:S245 62.06616.97YesYes165
83B:B:D228 B:B:D246 31.34956.65YesNo169
84B:B:D246 B:B:S245 31.20142.94NoYes195
85B:B:D247 B:B:S227 35.98414.42YesYes193
86B:B:D247 B:B:H225 31.10947.56YesYes196
87B:B:H225 B:B:R251 12.702216.93YesYes168
88B:B:F253 B:B:R251 14.70822.14YesYes178
89B:B:M262 B:B:Y264 11.766610.78NoYes1051
90B:B:L285 B:B:Y264 10.9473.52NoYes051
91B:B:C250 B:B:Y264 22.63034.03NoYes061
92B:B:L318 B:B:S275 15.63413YesNo078
93B:B:S275 B:B:T274 16.0554.8NoNo086
94R:R:R125 R:R:Y324 39.44174.12YesYes1399
95R:R:L118 R:R:Y324 39.21757.03YesYes099
96R:R:F279 R:R:L118 39.46822.44NoYes099
97R:R:F279 R:R:M115 38.37436.22NoYes098
98R:R:M115 R:R:W283 19.88984.65YesYes088
99R:R:W283 R:R:Y286 14.52992.89YesYes287
100R:R:T310 R:R:Y286 11.53894.99NoYes267
101R:R:T310 R:R:W311 11.39922.43NoYes267
102R:R:I121 R:R:R125 14.82253.76YesYes1399
103R:R:M115 R:R:W192 17.25572.33YesYes086
104B:B:L117 B:B:W99 11.53234.56YesYes198
105A:A:V224 A:A:W234 21.495113.48NoYes199
106B:B:L117 B:B:Y145 63.02812.34YesYes198
107B:B:C250 B:B:I273 23.14224.91NoNo064
108B:B:D290 B:B:T274 16.52414.34YesNo076
109B:B:L318 B:B:T329 12.70774.42YesNo075
110A:A:F238 B:B:L117 53.06642.44YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8SMV
Class A
SubFamily Orphan
Type Orphan
SubType GPR161
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.74
Date 2024-02-21
D.O.I. 10.1038/s41594-024-01223-8
Net Summary
Imin 2.11
Number of Linked Nodes 840
Number of Links 1042
Number of Hubs 170
Number of Links mediated by Hubs 637
Number of Communities 29
Number of Nodes involved in Communities 267
Number of Links involved in Communities 388
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 1049250
Length Of Smallest Path 3
Average Path Length 24.8931
Length of Longest Path 58
Minimum Path Strength 1.29
Average Path Strength 5.12614
Maximum Path Strength 18.34
Minimum Path Correlation 0.7
Average Path Correlation 0.975813
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 48.8921
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.1756
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • multicellular organismal process   • negative regulation of signaling   • regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning   • chordate embryonic development   • negative regulation of biological process   • pattern specification process   • regulation of signal transduction   • embryo development   • negative regulation of cell communication   • multicellular organism development   • embryo development ending in birth or egg hatching   • dorsal/ventral neural tube patterning   • negative regulation of smoothened signaling pathway   • negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning   • anatomical structure development   • negative regulation of cellular process   • smoothened signaling pathway involved in dorsal/ventral neural tube patterning   • regulation of smoothened signaling pathway   • system development   • developmental process   • epithelium development   • regulation of signaling   • neural tube development   • cell surface receptor signaling pathway   • tube development   • negative regulation of response to stimulus   • nervous system development   • tissue development   • negative regulation of signal transduction   • regionalization   • smoothened signaling pathway   • dorsal/ventral pattern formation   • regulation of response to stimulus   • neural tube patterning   • regulation of cell communication   • membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • intracellular anatomical structure   • membrane   • intracellular vesicle   • intracellular membrane-bounded organelle   • intracellular organelle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • cytoplasmic vesicle
Gene OntologyCellular Component• membrane-bounded organelle   • cell projection   • cellular anatomical structure   • organelle   • cilium   • plasma membrane bounded cell projection   • intracellular anatomical structure   • membrane   • intracellular vesicle   • intracellular membrane-bounded organelle   • intracellular organelle   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • cytoplasmic vesicle   • vesicle membrane   • endocytic vesicle membrane   • cytoplasm   • vesicle   • organelle membrane   • endocytic vesicle   • glial cell projection   • endosome   • recycling endosome   • endomembrane system   • plasma membrane   • ciliary membrane   • cell periphery   • plasma membrane region   • cell projection membrane   • neuron projection   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • synapse   • cell junction   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network   • enzyme binding   • GTPase binding   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • sensory perception of taste   • sensory organ development   • eye development   • retina development in camera-type eye   • visual system development   • camera-type eye development   • sensory system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • photoreceptor disc membrane   • photoreceptor outer segment   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8SMV_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LHTSGIFET KFQVDKVNF HMFDVGGQR DERRKWIQC 
FNDVTAIIF VVDSSDYNR LQEALNLFK SIWNNRWLR TISVILFLN 
KQDLLAEKV LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA 
KYFIRDEFL RISTASGDG RHYCYPHFT CAVDTENAR RIFNDCRDI 
IQRMHLRQY ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8SMV_Chain_B
QSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8SMV_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8N6U8
Sequence
>8SMV_Chain_R
ITQFIAIIV ITIFVCLGN LVIVVTLYK KSYLLTLSN KFVFSLTLS 
NFLLSVLVL PFVVTSSIR REWIFGVVW CNFSALLYL LISSASMLT 
LGVIAIDRY YAVLYPMVY PMKITGNRA VMALVYIWL HSLIGCLPP 
LFGWSSVEF DEFKWMCVA AWHREPGYT AFWQIWCAL FPFLVMLVC 
YGFIFRVAR VKARCKALI TILVVLGAF MVTWGPYMV VIASEALWG 
KSSVSPSLE TWATWLSFA SAVCHPLIY GLWNKTVRK ELLGMCF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8SMVAOrphanOrphanGPR161Homo sapiens--Gs/β1/γ22.742024-02-2110.1038/s41594-024-01223-8
8SMV (No Gprot) AOrphanOrphanGPR161Homo sapiens--2.742024-02-2110.1038/s41594-024-01223-8
8KH4AOrphanOrphanGPR161Homo sapiens--Gs/β1/γ23.12023-10-1110.1038/s41467-023-41654-3
8KH4 (No Gprot) AOrphanOrphanGPR161Homo sapiens--3.12023-10-1110.1038/s41467-023-41654-3




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