Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:V41 2.0375407
2R:R:Y57 8.354185
3R:R:F65 3.5025408
4R:R:L69 4.474219
5R:R:N73 4.0945219
6R:R:V80 2.70254227
7R:R:W93 6.95178
8R:R:F95 8.8185176
9R:R:Y107 4.64428
10R:R:M115 3.7025408
11R:R:L118 4.36409
12R:R:I121 3.2354159
13R:R:R125 5.574159
14R:R:Y126 4.5425409
15R:R:Y127 2.876505
16R:R:L130 3.445406
17R:R:M133 5.0775447
18R:R:Y135 4.3875408
19R:R:P161 4.2825426
20R:R:K175 9.648522
21R:R:W182 5.66625825
22R:R:R184 6.06754233
23R:R:Y188 7.544528
24R:R:W192 4.785626
25R:R:W195 9.244504
26R:R:M204 2.76254158
27R:R:Y208 4.2625159
28R:R:F212 2.5406
29R:R:W283 4.93728
30R:R:Y286 4.50333627
31R:R:M287 3.9475407
32R:R:I290 8.0675427
33R:R:E293 4.58571724
34R:R:E306 7.316525
35R:R:W311 5.684527
36R:R:F314 4.7575427
37R:R:Y324 4.915159
38R:R:L335 3.7075407
39G:G:I9 2.25122
40G:G:R27 4.1325408
41G:G:D48 5.29833609
42G:G:L51 4.0554166
43G:G:N59 4.555109
44G:G:P60 6.8254109
45G:G:F61 4.568758108
46A:A:H41 4.662546
47A:A:N50 6.24559
48A:A:K53 5.642559
49A:A:V214 4.33446
50A:A:F219 5.33667648
51A:A:F222 4.655417
52A:A:Q227 5.584519
53A:A:K233 5.6525419
54A:A:W234 5.858519
55A:A:F238 5.68333619
56A:A:T242 3.3175408
57A:A:V247 4.25457
58A:A:D249 8.2875458
59A:A:Y253 5.6565258
60A:A:R265 7.755459
61A:A:L270 4.225406
62A:A:F273 4.145409
63A:A:W277 8.2256206
64A:A:W281 8.56833615
65A:A:V287 3.21754206
66A:A:I288 3.754539
67A:A:F290 3.712539
68A:A:K293 6.6725459
69A:A:L296 4.1975456
70A:A:L297 3.4625408
71A:A:F312 3.5556268
72A:A:F315 8.81506
73A:A:E330 6.138563
74A:A:D331 7.4375464
75A:A:V334 3.6564
76A:A:K338 8.6025465
77A:A:Y339 3.896503
78A:A:F340 9.7654267
79A:A:R342 4.944564
80A:A:E344 6.4854265
81A:A:F345 5.9025408
82A:A:Y360 5.59833638
83A:A:F363 9.045465
84A:A:T364 4.8525439
85A:A:D368 6.29439
86A:A:N371 6.23439
87A:A:R373 5.13445
88A:A:R374 5.17534
89A:A:F376 3.83648
90A:A:I383 3.565448
91A:A:H387 4.29448
92A:A:L388 3.9075408
93A:A:Y391 7.026504
94A:A:L393 2.49508
95B:B:L7 4.3585121
96B:B:L14 4.5725401
97B:B:D27 7.5575403
98B:B:L30 4.4025403
99B:B:V40 4.97254161
100B:B:R48 2.0325103
101B:B:H54 7.9585119
102B:B:K57 10.16517
103B:B:Y59 7.978519
104B:B:W63 6.452506
105B:B:Q75 9.065419
106B:B:D76 6.7775409
107B:B:W82 9.9365117
108B:B:K89 4.851437117
109B:B:I93 3.62486
110B:B:L95 4.66585
111B:B:W99 5.79429718
112B:B:Y105 3.3475407
113B:B:Y111 5.83404
114B:B:C114 5.01489
115B:B:L117 3.88333619
116B:B:Y124 4.14333686
117B:B:V133 3.565483
118B:B:H142 5.94833615
119B:B:Y145 4.33571718
120B:B:F151 4.58506
121B:B:L152 4.1975409
122B:B:D163 8.7575419
123B:B:T165 3.6375416
124B:B:W169 8.01333616
125B:B:F180 7.4574
126B:B:H183 6.63571776
127B:B:L190 4.0875407
128B:B:A193 2.72415
129B:B:V200 3.8125419
130B:B:C204 4.33418
131B:B:D205 6.7477
132B:B:K209 8.8075476
133B:B:L210 3.695416
134B:B:W211 7.67833675
135B:B:R219 5.4415
136B:B:Q220 6.446515
137B:B:H225 7.71833616
138B:B:S227 4.495413
139B:B:D228 7.312516
140B:B:I232 3.63415
141B:B:F234 4.9225413
142B:B:F235 6.296676195
143B:B:P236 4.964196
144B:B:F241 5.15833616
145B:B:T243 4.12614
146B:B:S245 5.87415
147B:B:D247 7.204519
148B:B:T249 4.6625415
149B:B:R251 9.892518
150B:B:F253 5.35167617
151B:B:Y264 5.60167691
152B:B:H266 7.4525492
153B:B:I269 2.735494
154B:B:V276 2.16408
155B:B:F278 4.50754195
156B:B:R283 5.847147169
157B:B:L284 3.9025409
158B:B:Y289 6.262597
159B:B:D290 7.7825417
160B:B:N295 6.0575495
161B:B:W297 6.49495
162B:B:K301 4.57406
163B:B:H311 7.515135
164B:B:R314 15.6175417
165B:B:V315 2.63254138
166B:B:L318 2.956507
167B:B:W332 8.41857719
168B:B:D333 8.5354139
169B:B:K337 4.0865137
170B:B:W339 10.56754135
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:F279 R:R:L118 39.45692.44NoYes099
2R:R:F279 R:R:M115 38.36286.22NoYes098
3R:R:M115 R:R:W283 19.88244.65YesYes088
4R:R:W283 R:R:Y286 14.52412.89YesYes287
5R:R:T310 R:R:Y286 11.53084.99NoYes267
6R:R:T310 R:R:W311 11.39032.43NoYes267
7R:R:L118 R:R:Y324 39.2117.03YesYes099
8B:B:L318 B:B:T329 12.6444.42YesNo075
9B:B:L318 B:B:S275 15.55533YesNo078
10B:B:S275 B:B:T274 15.97264.8NoNo086
11B:B:D290 B:B:T274 16.43784.34YesNo076
12A:A:W281 B:B:W332 10.12472.81YesYes159
13B:B:W332 B:B:Y59 36.74845.79YesYes199
14A:A:C237 B:B:Y59 17.56225.38NoYes189
15A:A:C237 A:A:F238 18.01222.79NoYes189
16A:A:F238 A:A:L44 93.948514.61YesNo099
17A:A:L44 A:A:L46 93.7734.15NoNo098
18A:A:G47 A:A:L46 93.59721.71NoNo098
19A:A:G47 A:A:K53 93.42095.23NoYes099
20A:A:K53 A:A:L45 88.69337.05YesNo098
21A:A:I245 A:A:L45 86.80112.85NoNo078
22A:A:I245 A:A:I288 81.66982.94NoYes379
23A:A:A243 A:A:I288 80.59281.62NoYes089
24A:A:A243 A:A:T242 80.74261.68NoYes088
25A:A:H41 A:A:T242 79.90925.48YesYes068
26A:A:H41 A:A:I383 75.5852.65YesYes468
27A:A:H387 A:A:I383 74.82175.3YesYes488
28A:A:H387 A:A:Q390 75.05066.18YesNo084
29A:A:Q390 A:A:Y391 74.830318.04NoYes044
30A:A:Y391 R:R:R125 58.16148.23YesYes049
31R:R:R125 R:R:Y324 39.43884.12YesYes1599
32B:B:L14 G:G:A23 14.3071.58YesNo018
33B:B:I18 G:G:A23 16.69013.25NoNo048
34B:B:I18 B:B:R22 19.07273.76NoNo044
35B:B:D258 B:B:R22 21.4555.96NoNo074
36B:B:D258 B:B:Q220 30.976710.44NoYes075
37B:B:F222 B:B:Q220 32.63867.03NoYes175
38B:B:F222 B:B:F241 10.66599.65NoYes176
39B:B:F241 B:B:T243 30.76282.59YesYes164
40B:B:H225 B:B:T243 79.76855.48YesYes164
41B:B:H225 B:B:S245 62.11536.97YesYes165
42B:B:S227 B:B:S245 31.22433.26YesYes135
43B:B:D228 B:B:S227 67.29972.94YesYes163
44A:A:K233 B:B:D228 98.13866.91YesYes196
45A:A:K233 B:B:Y145 1002.39YesYes198
46B:B:L117 B:B:Y145 62.66092.34YesYes198
47A:A:F238 B:B:L117 52.75732.44YesYes199
48B:B:L255 B:B:Q220 10.09613.99NoYes195
49B:B:F241 B:B:L255 14.54262.44YesNo169
50B:B:F222 B:B:F253 23.79627.5NoYes177
51B:B:F253 B:B:T243 11.91363.89YesYes174
52B:B:F253 B:B:R251 14.62342.14YesYes178
53B:B:H225 B:B:R251 12.62916.93YesYes168
54B:B:D247 B:B:H225 31.13397.56YesYes196
55B:B:D247 B:B:S227 35.98224.42YesYes193
56B:B:D246 B:B:S245 31.22552.94NoYes195
57B:B:D228 B:B:D246 31.37326.65YesNo169
58B:B:S147 B:B:S160 13.2554.89NoNo079
59B:B:M188 B:B:S147 13.54083.07NoNo097
60A:A:K233 B:B:M188 14.130910.08YesNo099
61B:B:L285 B:B:Y264 10.91843.52NoYes051
62B:B:C250 B:B:Y264 22.46934.03NoYes061
63B:B:C250 B:B:I273 22.9774.91NoNo064
64B:B:G244 B:B:I273 37.01615.29NoNo084
65B:B:G244 B:B:T243 39.54223.64NoYes084
66B:B:L30 B:B:M262 11.22822.83YesNo035
67B:B:M262 B:B:Y264 11.69410.78NoYes951
68B:B:M61 B:B:W63 17.79773.49NoYes076
69B:B:C317 B:B:M61 18.22214.86NoNo097
70B:B:C317 B:B:S316 18.69513.44NoNo097
71B:B:S316 B:B:W332 18.9612.47NoYes079
72B:B:S122 B:B:Y124 13.94845.09NoYes086
73B:B:E138 B:B:S122 14.3014.31NoNo058
74B:B:E138 B:B:I120 15.11012.73NoNo059
75B:B:D118 B:B:I120 15.52864.2NoNo099
76B:B:D118 B:B:S97 15.95628.83NoNo096
77B:B:S97 B:B:W99 16.38992.47NoYes068
78A:A:F238 A:A:V224 21.78252.62YesNo199
79A:A:V224 A:A:W234 21.369913.48NoYes199
80A:A:R231 A:A:W234 73.82114NoYes099
81A:A:L272 A:A:R231 73.55513.64NoNo089
82A:A:F273 A:A:F345 16.0627.5YesYes098
83A:A:F345 A:A:V248 35.9533.93YesNo087
84A:A:F246 A:A:V248 36.53612.62NoNo097
85A:A:F246 A:A:L272 73.0246.09NoNo098
86A:A:F345 A:A:L289 35.92964.87YesNo089
87A:A:F246 A:A:L289 36.22123.65NoNo099
88A:A:L297 A:A:Y253 15.43023.52YesYes088
89A:A:I308 A:A:Y253 21.82310.88NoYes078
90A:A:F312 A:A:I308 23.07562.51YesNo087
91A:A:F312 A:A:Q267 14.73312.34YesNo084
92A:A:L270 A:A:Q267 15.98512.66YesNo064
93A:A:F345 A:A:L270 55.79937.31YesYes086
94A:A:E344 A:A:F312 14.71584.66YesYes2658
95A:A:E344 A:A:L270 37.08472.65YesYes056
96A:A:P321 A:A:Y318 10.93254.17NoNo056
97A:A:F340 A:A:Y318 16.06989.28YesNo076
98A:A:E344 A:A:F340 21.112910.49YesYes2657
99A:A:L297 A:A:V301 10.2962.98YesNo087
100B:B:H142 B:B:S161 15.956612.55YesNo156
101B:B:G162 B:B:S161 17.89923.71NoNo196
102B:B:G162 B:B:Y145 18.15564.35NoYes198
103B:B:H142 B:B:W169 11.76753.17YesYes156
104B:B:I273 B:B:Y289 13.57457.25NoYes047
105R:R:I121 R:R:R125 14.823.76YesYes1599
106R:R:M115 R:R:W192 17.25052.33YesYes086
107B:B:M101 B:B:Y145 19.16563.59NoYes198
108B:B:M101 B:B:Y59 19.38243.59NoYes199
109A:A:W234 B:B:Y145 49.60972.89YesYes198
110B:B:L117 B:B:W99 11.46514.56YesYes198
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8SMV
Class A
SubFamily Orphan
Type A orphans
SubType GPR161
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 2.74
Date 2024-02-21
D.O.I. 10.1038/s41594-024-01223-8
Net Summary
Imin 2.11
Number of Linked Nodes 842
Number of Links 1047
Number of Hubs 170
Number of Links mediated by Hubs 638
Number of Communities 29
Number of Nodes involved in Communities 270
Number of Links involved in Communities 393
Path Summary
Number Of Nodes in MetaPath 111
Number Of Links MetaPath 110
Number of Shortest Paths 1060568
Length Of Smallest Path 3
Average Path Length 24.9255
Length of Longest Path 58
Minimum Path Strength 1.29
Average Path Strength 5.12167
Maximum Path Strength 18.34
Minimum Path Correlation 0.7
Average Path Correlation 0.976067
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 48.8897
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.0351
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8N6U8
Sequence
>8SMV_Chain_R
ITQFIAIIV ITIFVCLGN LVIVVTLYK KSYLLTLSN KFVFSLTLS 
NFLLSVLVL PFVVTSSIR REWIFGVVW CNFSALLYL LISSASMLT 
LGVIAIDRY YAVLYPMVY PMKITGNRA VMALVYIWL HSLIGCLPP 
LFGWSSVEF DEFKWMCVA AWHREPGYT AFWQIWCAL FPFLVMLVC 
YGFIFRVAR VKARCKALI TILVVLGAF MVTWGPYMV VIASEALWG 
KSSVSPSLE TWATWLSFA SAVCHPLIY GLWNKTVRK ELLGMCF


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8SMV_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8SMV_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LHTSGIFET KFQVDKVNF HMFDVGGQR DERRKWIQC 
FNDVTAIIF VVDSSDYNR LQEALNLFK SIWNNRWLR TISVILFLN 
KQDLLAEKV LAGKSKIED YFPEFARYT TPEDATPEP GEDPRVTRA 
KYFIRDEFL RISTASGDG RHYCYPHFT CAVDTENAR RIFNDCRDI 
IQRMHLRQY ELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8SMV_Chain_B
QSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8KH4AOrphanA orphansGPR161Homo sapiens--Gs/&β;1/&γ;23.12023-10-1110.1038/s41467-023-41654-3
8SMVAOrphanA orphansGPR161Homo sapiens--Gs/&β;1/&γ;22.742024-02-2110.1038/s41594-024-01223-8




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 8SMV.zip



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