Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 8.045416
2A:A:R42 7.86409
3A:A:L43 4.41417
4A:A:L44 10.4439
5A:A:L45 6.6175418
6A:A:K53 7.37419
7A:A:I207 5.435439
8A:A:F212 5.734519
9A:A:V214 5.33516
10A:A:F219 6.78429718
11A:A:H220 12.505437
12A:A:F222 11.22537
13A:A:V224 4.745439
14A:A:Q227 6.23333639
15A:A:R228 7.445439
16A:A:E230 9.44439
17A:A:K233 5.80143739
18A:A:W234 6.576539
19A:A:I235 3.0175439
20A:A:C237 3.99538
21A:A:F238 8.44667639
22A:A:I245 4.0025417
23A:A:V247 3.906517
24A:A:V248 4.215407
25A:A:Y253 10.585408
26A:A:F273 4.85143759
27A:A:W277 9.394556
28A:A:R280 8.445435
29A:A:W281 13.39635
30A:A:L282 5.9425409
31A:A:I288 5.072519
32A:A:F290 4.334519
33A:A:N292 4.3925409
34A:A:K293 7.734169
35A:A:Q294 5.915456
36A:A:Y311 6.6025406
37A:A:F315 10.774506
38A:A:Y318 8.22456
39A:A:E330 7.8825403
40A:A:V334 4.205404
41A:A:K338 7.705455
42A:A:Y339 7.9075453
43A:A:F340 9.334557
44A:A:R342 6.052554
45A:A:F345 8.105408
46A:A:S349 4.7457
47A:A:Y358 6.235414
48A:A:C359 3.436555
49A:A:Y360 7.812518
50A:A:F363 6.662555
51A:A:D368 4.9675409
52A:A:R373 6.565415
53A:A:F376 8.03833618
54A:A:R385 8.5125415
55A:A:H387 5.5275408
56A:A:L388 4.86418
57A:A:Y391 6.564174
58A:A:L394 4.785418
59B:B:L7 5.045408
60B:B:R22 7.0375446
61B:B:I33 2.74403
62B:B:V40 5.164523
63B:B:M45 3.448524
64B:B:L51 6.614529
65B:B:H54 8.43729
66B:B:K57 11.142539
67B:B:Y59 10.29538
68B:B:M61 5.4675426
69B:B:W63 6.635627
70B:B:L70 6.375425
71B:B:V71 5.098578
72B:B:D76 6.3725409
73B:B:K78 4.864528
74B:B:L79 3.82577
75B:B:I80 6.994528
76B:B:I81 5.148577
77B:B:W82 10.1814729
78B:B:D83 9.58254158
79B:B:Y85 10.895424
80B:B:N88 8.8354157
81B:B:K89 6.90714729
82B:B:I93 5.405477
83B:B:L95 4.5575408
84B:B:W99 8.63739
85B:B:M101 4.21439
86B:B:Y105 4.875676
87B:B:N110 6.20254124
88B:B:Y111 7.0525124
89B:B:V112 4.385478
90B:B:L117 4.566539
91B:B:I123 4.3925126
92B:B:Y124 4.80571776
93B:B:L126 4.185475
94B:B:V133 4.65474
95B:B:L139 7.0825409
96B:B:H142 8.005639
97B:B:Y145 6.2838
98B:B:L146 4.38437
99B:B:F151 4.00333609
100B:B:L152 3.8775463
101B:B:V158 4.554565
102B:B:T159 5.14639
103B:B:S161 8.145439
104B:B:D163 7.316539
105B:B:C166 4.235468
106B:B:L168 4.642566
107B:B:W169 11.382538
108B:B:Q176 6.6275434
109B:B:F180 8.388567
110B:B:H183 7.98143769
111B:B:D186 5.242539
112B:B:V187 4.426569
113B:B:M188 4.5675438
114B:B:L190 6.045465
115B:B:L192 4.0775465
116B:B:F199 8.528569
117B:B:V200 6.2575446
118B:B:S201 5.2625469
119B:B:C204 5.878537
120B:B:D205 6.404569
121B:B:K209 11.5725466
122B:B:L210 6.5875445
123B:B:W211 9.57167668
124B:B:Q220 8.488547
125B:B:F222 9.5425448
126B:B:H225 9.43286749
127B:B:D228 9.22439
128B:B:I229 5.005447
129B:B:I232 5.09448
130B:B:F234 6.0825405
131B:B:F235 6.32826
132B:B:P236 5.2925427
133B:B:F241 5.62714746
134B:B:T243 5.54548
135B:B:D247 7.672549
136B:B:R251 11.5548
137B:B:F253 8.01646
138B:B:D254 5.2925409
139B:B:D258 10.566547
140B:B:Q259 3.6975406
141B:B:E260 6.0625446
142B:B:Y264 7.22333625
143B:B:F278 5.426527
144B:B:R283 6.35571729
145B:B:L284 5.18425
146B:B:L285 5.375426
147B:B:Y289 7.958527
148B:B:D290 6.54167636
149B:B:N295 8.345426
150B:B:V296 4.645405
151B:B:W297 8.035428
152B:B:K301 6.8375405
153B:B:L308 10.2925407
154B:B:H311 9.3785139
155B:B:R314 16.022538
156B:B:L318 4.6475406
157B:B:M325 4.8225425
158B:B:V327 5426
159B:B:T329 5.8408
160B:B:W332 12.7186739
161B:B:D333 9.06254139
162B:B:L336 5.876527
163B:B:K337 8.24754136
164B:B:W339 10.5985139
165B:B:N340 6.02833629
166G:G:I25 7.5625442
167G:G:R27 6.61333648
168G:G:Y40 8.8375426
169G:G:D48 6.02333609
170G:G:L51 3.4075426
171G:G:N59 7.295429
172G:G:P60 7.855429
173G:G:F61 5.23125828
174R:R:L220 5.0025143
175R:R:Y222 9.59254146
176R:R:F224 6.534297106
177R:R:L225 7.14106
178R:R:P233 4.4625107
179R:R:E235 8.1125484
180R:R:P236 2.6525485
181R:R:M243 9.85754107
182R:R:F245 8.626518
183R:R:R250 5.644586
184R:R:W260 8.645415
185R:R:T274 7.09499
186R:R:D278 7.7954189
187R:R:R281 5.81754189
188R:R:F282 6.492599
189R:R:Y284 7.5765119
190R:R:P288 4.715418
191R:R:L292 5.185418
192R:R:C295 3.2925419
193R:R:Y296 8.362518
194R:R:F297 5.71505
195R:R:H303 3.83667616
196R:R:D311 7.42586
197R:R:V314 3.44408
198R:R:C315 5.235489
199R:R:V316 3.14754145
200R:R:F319 6.8054144
201R:R:Y324 12.845482
202R:R:R325 5.66333684
203R:R:Q329 5.61407
204R:R:F340 8.39419
205R:R:M341 3.2825408
206R:R:L343 5.2416
207R:R:Y344 6.00375819
208R:R:F345 5.562508
209R:R:F346 8.12419
210R:R:M348 5.7275408
211R:R:I352 5.3725416
212R:R:W353 8.075819
213R:R:W361 5.935419
214R:R:W369 4.724119
215R:R:I374 4.85754119
216R:R:F381 3.97408
217R:R:W386 5.40333619
218R:R:P389 4.0125419
219R:R:I396 10.3875417
220R:R:D403 6.36409
221R:R:L407 6.44667618
222R:R:V410 2.78517
223R:R:Y412 5.844516
224R:R:V413 5.8725419
225R:R:L421 3.9425419
226R:R:R422 6.1454216
227R:R:F424 5.914518
228R:R:F444 5.3418
229R:R:R451 6.155419
230R:R:M454 5.585618
231R:R:L464 4.19418
232R:R:M468 6.245419
233R:R:I471 5.975419
234R:R:Y478 15.7575418
235R:R:P481 5.135419
236R:R:L486 2.2525408
237R:R:Y489 5.235614
238R:R:Y491 8.675419
239R:R:E492 6.732519
240R:R:Q493 6.93754216
241R:R:W499 4.922519
242R:R:W503 8.6685105
243R:R:F527 8.06833616
244R:R:F530 6.142517
245R:R:M531 5.612518
246R:R:K533 5.538519
247R:R:Y534 4.865618
248R:R:L535 5.1875417
249R:R:M536 5.6525418
250R:R:M538 3.32518
251R:R:I539 4.6025417
252R:R:W547 9.2675409
253R:R:I548 4.3625498
254R:R:W557 8.62599
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:D76 B:B:K78 22.10788.3YesYes098
2B:B:A56 B:B:D76 37.16124.63NoYes079
3A:A:Y37 B:B:A56 37.35942.67NoNo047
4A:A:R42 A:A:Y37 37.559211.32YesNo094
5A:A:D240 A:A:R42 26.715514.29NoYes069
6A:A:D240 A:A:N239 12.969710.77NoNo368
7A:A:N239 B:B:W332 13.045510.17NoYes389
8A:A:W281 B:B:W332 30.55419.37YesYes359
9A:A:R280 A:A:W281 50.336319.99YesYes355
10A:A:R280 A:A:R283 79.27384.26YesNo053
11A:A:R283 A:A:R356 79.30714.26NoNo032
12A:A:R356 A:A:R389 79.37356.4NoNo024
13A:A:M386 A:A:R389 79.40698.69NoNo034
14A:A:H387 A:A:M386 79.44172.63YesNo083
15A:A:H387 A:A:I383 79.79653.98YesNo088
16A:A:H41 A:A:I383 79.8335.3YesNo068
17A:A:D240 B:B:K57 13.8876.91NoYes369
18B:B:K57 B:B:W332 14.080518.57YesYes399
19A:A:F219 A:A:H41 79.62979.05YesYes186
20A:A:F219 A:A:L43 80.48074.87YesYes187
21A:A:I245 A:A:L43 79.59672.85YesYes177
22A:A:F290 A:A:V247 10.1462.62YesYes197
23A:A:F363 A:A:Q294 11.35857.03YesYes556
24A:A:L297 A:A:Q294 13.63443.99NoYes586
25A:A:L297 A:A:Y253 13.88163.52NoYes088
26A:A:Y253 A:A:Y311 17.06469.93YesYes086
27A:A:N264 A:A:Y311 17.495912.79NoYes096
28A:A:D252 A:A:N264 17.60382.69NoNo089
29A:A:D249 A:A:D252 18.0355.32NoNo088
30A:A:D249 A:A:K293 18.09115.21NoYes1689
31A:A:K293 A:A:N292 18.6755.6YesYes099
32A:A:K233 B:B:Y145 19.29723.58YesYes398
33A:A:Q236 A:A:W281 19.76947.67NoYes385
34A:A:K233 A:A:Q236 20.47762.71YesNo398
35A:A:I245 A:A:I288 80.03655.89YesYes179
36A:A:R280 B:B:D291 14.38145.96YesNo058
37A:A:D378 A:A:I288 99.5089.8NoYes179
38A:A:D378 A:A:Y360 10014.94NoYes178
39A:A:Y358 A:A:Y360 74.95333.97YesYes148
40A:A:R385 A:A:Y358 25.105713.38YesYes154
41A:A:D381 A:A:Y360 25.11611.49NoYes088
42A:A:D381 A:A:R385 25.089210.72NoYes085
43A:A:L394 A:A:Y358 49.864.69YesYes184
44A:A:L388 A:A:L394 49.83884.15YesYes188
45A:A:R385 R:R:T459 50.12383.88YesNo056
46R:R:M454 R:R:T459 49.910612.04YesNo086
47A:A:L388 R:R:M454 24.98028.48YesYes188
48A:A:L388 A:A:L393 24.76034.15YesNo088
49R:R:L464 R:R:M454 74.18132.83YesYes188
50A:A:L393 R:R:L464 24.73275.54NoYes088
51B:B:R283 B:B:V40 15.0066.54YesYes293
52B:B:R283 G:G:C41 18.25224.18YesNo297
53B:B:F235 G:G:C41 18.75182.79YesNo267
54B:B:F235 B:B:F278 20.49247.5YesYes267
55B:B:F278 B:B:L285 22.05969.74YesYes276
56B:B:L285 B:B:Y264 22.53587.03YesYes265
57B:B:I338 B:B:L51 11.30412.85NoYes259
58B:B:H54 B:B:S74 10.175715.34YesNo299
59B:B:S147 B:B:Y145 19.57472.54NoYes098
60B:B:S147 B:B:S160 19.38234.89NoNo096
61B:B:S160 B:B:V187 13.56094.85NoYes069
62B:B:H183 B:B:V187 10.97555.54YesYes699
63B:B:C271 B:B:D290 16.81556.22NoYes056
64B:B:C271 B:B:Y289 30.9454.03NoYes057
65B:B:W297 B:B:Y264 27.161510.61YesYes285
66B:B:W297 B:B:Y289 28.08226.75YesYes287
67R:R:L447 R:R:L464 98.4024.15NoYes188
68R:R:L447 R:R:W361 98.3242.28NoYes189
69R:R:F444 R:R:W361 86.2379.02YesYes189
70R:R:F444 R:R:S475 85.96122.64YesNo188
71R:R:L440 R:R:S475 85.81516.01NoNo188
72R:R:L440 R:R:W354 85.29943.42NoNo189
73R:R:W354 R:R:Y478 85.17138.58NoYes198
74R:R:V540 R:R:Y478 49.00836.31NoYes188
75R:R:P481 R:R:V540 48.9453.53YesNo198
76R:R:M536 R:R:P481 22.70656.71YesYes189
77R:R:L535 R:R:M536 22.3554.24YesYes178
78R:R:L535 R:R:W256 43.25976.83YesNo178
79R:R:M531 R:R:W256 43.05673.49YesNo188
80R:R:L407 R:R:M531 20.97462.83YesYes188
81R:R:F245 R:R:L407 15.777218.27YesYes188
82R:R:F245 R:R:Y244 30.93024.13YesNo084
83R:R:M243 R:R:Y244 30.440711.97YesNo074
84R:R:F224 R:R:M243 10.85434.98YesYes1067
85R:R:I539 R:R:P481 23.07426.77YesYes179
86R:R:I539 R:R:L535 22.37132.85YesYes177
87R:R:F527 R:R:M531 17.099914.93YesYes168
88R:R:F245 R:R:F527 15.65798.57YesYes186
89R:R:M243 R:R:P233 13.7455.03YesYes1077
90R:R:L292 R:R:Y478 32.77638.21YesYes188
91R:R:L292 R:R:W353 32.22183.42YesYes189
92R:R:W353 R:R:W386 18.14998.43YesYes199
93R:R:F345 R:R:W386 17.85987.02YesYes089
94R:R:F345 R:R:T393 15.09392.59YesNo089
95R:R:T393 R:R:Y344 13.00923.75NoYes099
96R:R:Y344 R:R:Y412 11.25684.96YesYes196
97R:R:I471 R:R:W361 11.28698.22YesYes199
98R:R:I471 R:R:W547 10.97893.52YesYes099
99B:B:D76 B:B:S74 14.08994.42YesNo099
100A:A:R280 B:B:D290 14.5683.57YesYes356
101B:B:C271 B:B:D291 14.296712.45NoNo058
102A:A:F290 A:A:I288 19.52093.77YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 8YY8
Class F
SubFamily Protein
Type Frizzled
SubType FZD7
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.22
Date 2024-04-24
D.O.I. 10.1038/s41422-021-00525-6
Net Summary
Imin 2.54
Number of Linked Nodes 913
Number of Links 1224
Number of Hubs 254
Number of Links mediated by Hubs 868
Number of Communities 21
Number of Nodes involved in Communities 363
Number of Links involved in Communities 585
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 4391779
Length Of Smallest Path 3
Average Path Length 38.9
Length of Longest Path 64
Minimum Path Strength 1.295
Average Path Strength 6.87244
Maximum Path Strength 25.49
Minimum Path Correlation 0.7
Average Path Correlation 0.993988
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 42.0856
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 61.1109
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>8YY8_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRILHT SGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNLFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTENARRIF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>8YY8_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>8YY8_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO75084
Sequence
>8YY8_Chain_R
CPRQLKVPP YLGYRFLGE RDCGAPCEP GRANGLMYF KEEERRFAR 
LWVGVWSVL CCASTLFTV LTYLVDMRR FSYPERPII FLSGCYFMV 
AVAHVAGFL LEDRAVCVE RFSDDGYRT VAQGTKKEG CTILFMVLY 
FFGMASSIW WVILSLTWF LAAGMKWGH EAIEANSQY FHLAAWAVP 
AVKTITILA MGQVDGDLL SGVCYVGLS SVDALRGFV LAPLFVYLF 
IGTSFLLAG FVSLFRIRT IMKHDGTKT EKLEKLMVR IGVFSVLYT 
VPATIVLAC YFYEQAFRE HWERTWLLQ TCDFTVFMI KYLMTMIVG 
ITTGFWIWS GKTLQSWRR FYH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7EVWFProteinFrizzledFZD7Homo sapiens--Gs/&β;1/&γ;23.222021-08-0410.1038/s41422-021-00525-6




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