Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I207 6.53479
2A:A:F212 7.1675409
3A:A:V214 7.6454156
4A:A:F219 6.925717158
5A:A:H220 11.4775477
6A:A:M221 5.595408
7A:A:Q227 6.402579
8A:A:K233 7.4265209
9A:A:W234 6.37779
10A:A:F238 10.474579
11A:A:F273 5.9656289
12A:A:W277 11.3554286
13A:A:W281 12.86336115
14A:A:I288 5.9565239
15A:A:F290 6.6454239
16A:A:Q294 7.99436
17A:A:I308 7.4275437
18A:A:F312 5.942538
19A:A:F315 10.562536
20A:A:P321 4.755435
21A:A:E330 6.855403
22A:A:V334 4.2625404
23A:A:F340 10.548537
24A:A:R342 6.812534
25A:A:F345 9.92408
26A:A:Y358 7.514164
27A:A:Y360 8.245168
28A:A:F363 8.566535
29A:A:D368 5.86409
30A:A:R373 6.52754155
31A:A:F376 8.851676158
32A:A:R385 10.7754165
33A:A:L388 5.5525408
34A:A:Y391 7.5354104
35A:A:L394 5.5585168
36B:B:L14 5.3875408
37B:B:I18 5.585417
38B:B:R22 8.495416
39B:B:T34 4.54125
40B:B:I37 4.5554122
41B:B:H54 7.87333629
42B:B:K57 12.1154119
43B:B:I58 5.875429
44B:B:W63 6.65167627
45B:B:D76 6.326529
46B:B:L79 4.415407
47B:B:W82 10.4567629
48B:B:N88 9.834227
49B:B:K89 6.73833609
50B:B:I93 6.724187
51B:B:L95 4.475408
52B:B:W99 8.69879
53B:B:Y105 5.184506
54B:B:Y111 6.78404
55B:B:L117 5.884579
56B:B:I123 6.175406
57B:B:Y124 6.1485186
58B:B:L139 8.1225409
59B:B:H142 8.1665139
60B:B:Y145 8.894578
61B:B:R150 5.844326
62B:B:F151 5.775609
63B:B:D163 7.364139
64B:B:L168 5.0625456
65B:B:W169 9.541676138
66B:B:F180 8.736557
67B:B:H183 7.72659
68B:B:L190 4.744325
69B:B:F199 8.576559
70B:B:V200 7.24416
71B:B:C204 7.154207
72B:B:D205 6.125459
73B:B:K209 12.1525456
74B:B:L210 6.92405
75B:B:W211 9.25333658
76B:B:Q220 8.29417
77B:B:F222 9.19418
78B:B:H225 9.17857719
79B:B:D228 9.91254209
80B:B:I232 5.7925418
81B:B:F234 6.41405
82B:B:F235 7.205717196
83B:B:P236 7.0854197
84B:B:F241 7.13833616
85B:B:S245 7.085419
86B:B:D247 6.404519
87B:B:R251 10.225618
88B:B:F253 7.21333616
89B:B:D258 10.222517
90B:B:Q259 3.6775406
91B:B:E260 6.9975416
92B:B:Y264 7.64667605
93B:B:F278 6.24254197
94B:B:R283 6.915717129
95B:B:L284 5.574505
96B:B:L285 4.89506
97B:B:Y289 7.4965247
98B:B:D290 7.814116
99B:B:N295 9.9554246
100B:B:W297 8.0454248
101B:B:L300 6.19254126
102B:B:K301 7.565405
103B:B:R314 15.3645118
104B:B:M325 4.808525
105B:B:W332 13.14147119
106B:B:D333 8.084359
107B:B:L336 5.725427
108B:B:W339 10.5985319
109G:G:I25 7.42412
110G:G:R27 8.245618
111G:G:Y40 9.40754196
112G:G:D48 6.98409
113G:G:L51 4.005406
114G:G:N59 5.865429
115G:G:P60 8.215429
116G:G:F61 5.61143728
117R:R:L220 5.564253
118R:R:Y222 10.1454256
119R:R:F224 6.344297146
120R:R:C230 5.23754149
121R:R:P233 5.7425147
122R:R:C234 6.9625489
123R:R:E235 6.9275484
124R:R:M243 10.56754147
125R:R:F245 8.588548
126R:R:R250 6.152586
127R:R:R254 6.89486
128R:R:W256 10.0325448
129R:R:T274 6.372569
130R:R:Y275 11.525408
131R:R:D278 8.1625469
132R:R:R281 9.4775469
133R:R:F282 5.488569
134R:R:Y284 7.245717109
135R:R:Y296 9.0985268
136R:R:F297 5.9825375
137R:R:M298 7.18754376
138R:R:H303 4.614506
139R:R:D311 6.25833686
140R:R:F319 7.5525254
141R:R:Y324 12.99482
142R:R:R325 5.98584
143R:R:Q329 7.3475407
144R:R:F340 8.20167699
145R:R:M341 3.8525498
146R:R:Y344 6.9375899
147R:R:F345 5.068508
148R:R:W353 12.85219
149R:R:W369 7.38254109
150R:R:I374 5.08254109
151R:R:F381 5.514108
152R:R:W386 7.84219
153R:R:I396 11.1525497
154R:R:Y412 7.99596
155R:R:V413 7.088599
156R:R:R422 6.145406
157R:R:F424 5.924598
158R:R:Y432 6.1754386
159R:R:M454 6.1675408
160R:R:D457 3.644306
161R:R:L464 4.90254178
162R:R:M468 8.19754179
163R:R:Y478 16.84254268
164R:R:Y489 6.564594
165R:R:W499 6.1654369
166R:R:W503 12.10754145
167R:R:F527 9.88446
168R:R:F530 6.665447
169R:R:M531 7.815448
170R:R:K533 6.8875409
171R:R:Y534 5.956548
172R:R:M536 6.745448
173R:R:W547 9.4525409
174R:R:I548 5.346568
175R:R:W557 8.384569
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:N23 B:B:N88 16.496313.62NoYes077
2A:A:N23 B:B:K89 16.68096.99NoYes079
3A:A:L30 B:B:K78 17.98874.23NoNo058
4A:A:L30 B:B:K89 17.8044.23NoYes059
5B:B:D76 B:B:K78 18.72998.3YesNo098
6B:B:D76 B:B:L55 34.16926.79YesNo096
7A:A:Y37 B:B:L55 34.73147.03NoNo046
8A:A:R42 A:A:Y37 34.920510.29NoNo094
9A:A:D240 A:A:R42 35.113211.91NoNo069
10A:A:D240 B:B:K57 34.61675.53NoYes1169
11B:B:K57 B:B:Q75 34.764910.85YesNo099
12B:B:Q75 B:B:W99 35.38976.57NoYes099
13A:A:F238 B:B:W99 17.971418.04YesYes799
14A:A:F238 A:A:W234 77.44624.01YesYes799
15A:A:R231 A:A:W234 99.86726NoYes099
16A:A:L272 A:A:R231 99.91137.29NoNo089
17A:A:F246 A:A:L272 1007.31NoNo098
18A:A:F246 A:A:F273 66.22987.5NoYes099
19A:A:F273 A:A:F345 33.04868.57YesYes098
20A:A:F345 A:A:L270 65.840313.4YesNo086
21A:A:L266 A:A:L270 98.80824.15NoNo086
22A:A:F312 A:A:L266 98.659310.96YesNo088
23A:A:F312 A:A:I308 97.21795.02YesYes387
24A:A:I308 A:A:Y253 97.430110.88YesNo078
25A:A:Y253 A:A:Y311 97.27819.93NoNo086
26A:A:N264 A:A:Y311 97.125816.28NoNo096
27A:A:D252 A:A:N264 97.04964.04NoNo089
28A:A:D249 A:A:D252 96.74435.32NoNo088
29A:A:D249 A:A:K293 96.389719.36NoNo089
30A:A:K293 A:A:N292 96.18395.6NoNo099
31A:A:N292 A:A:T364 95.79957.31NoNo099
32A:A:F290 A:A:T364 95.02346.49YesNo099
33B:B:L117 B:B:W99 19.12786.83YesYes799
34A:A:W234 B:B:L117 18.80364.56YesYes799
35A:A:F246 A:A:L289 33.82483.65NoNo099
36A:A:F345 A:A:L289 32.92658.53YesNo089
37A:A:F273 A:A:I348 33.08276.28YesNo094
38A:A:I348 A:A:L270 33.04714.28NoNo046
39A:A:W281 B:B:W332 30.992210.31YesYes1159
40B:B:R314 B:B:W332 30.648724.99YesYes1189
41A:A:C237 B:B:Y59 59.59874.03NoNo088
42B:B:W332 B:B:Y59 60.05595.79YesNo098
43A:A:F290 A:A:I288 90.80695.02YesYes2399
44A:A:W281 B:B:D290 30.44118.93YesYes1156
45B:B:D290 B:B:R314 30.425814.29YesYes1168
46A:A:D378 A:A:I288 90.589311.2NoYes079
47A:A:D378 A:A:Y360 90.664517.24NoYes078
48A:A:L394 A:A:R389 82.67743.64YesNo084
49A:A:L394 A:A:Y358 85.63644.69YesYes1684
50A:A:Y358 A:A:Y360 87.85484.96YesYes1648
51A:A:M386 A:A:R389 82.34173.72NoNo034
52A:A:I383 A:A:M386 82.25774.37NoNo083
53A:A:H387 A:A:I383 82.17355.3NoNo088
54A:A:H387 A:A:Q390 82.00523.71NoNo084
55A:A:Q390 A:A:Y391 81.836611.27NoYes044
56A:A:Y391 R:R:P285 81.39458.34YesNo1049
57R:R:I374 R:R:P285 81.32965.08YesNo1099
58R:R:I374 R:R:Y284 80.56584.84YesYes1099
59B:B:D83 B:B:R68 15.477416.68NoNo085
60B:B:L284 B:B:V296 10.63745.96YesNo055
61B:B:G306 B:B:V296 14.77311.84NoNo045
62B:B:G306 B:B:V307 14.93261.84NoNo043
63B:B:N295 B:B:V307 15.57745.91YesNo063
64B:B:N295 B:B:Y289 16.03616.28YesYes2467
65B:B:I273 B:B:Y289 39.33486.04NoYes067
66B:B:G244 B:B:I273 39.26245.29NoNo056
67B:B:G244 B:B:S245 39.08873.71NoYes059
68B:B:H225 B:B:S245 36.942212.55YesYes199
69B:B:F253 B:B:H225 32.30694.53YesYes169
70B:B:F222 B:B:F253 26.96810.72YesYes186
71B:B:D258 B:B:F222 16.5634.78YesYes178
72B:B:C271 B:B:D290 60.55914.67NoYes056
73B:B:C271 B:B:Y289 60.45274.03NoYes057
74B:B:L70 B:B:W82 11.60466.83NoYes259
75B:B:L70 B:B:W63 10.655210.25NoYes257
76B:B:F222 B:B:Q220 10.254210.54YesYes187
77G:G:I25 G:G:M21 17.33514.37YesNo021
78B:B:T221 G:G:M21 16.97524.52NoNo071
79B:B:K209 B:B:T221 16.615113.51YesNo067
80B:B:K209 B:B:W211 10.836711.6YesYes568
81B:B:D66 B:B:R68 16.37843.57NoNo085
82B:B:D66 B:B:L69 16.01559.5NoNo085
83B:B:L69 B:B:Y105 15.65265.86NoYes056
84R:R:F381 R:R:Y284 76.14158.25YesYes1089
85R:R:F381 R:R:I356 76.00816.28YesNo086
86R:R:I356 R:R:W353 75.919910.57NoYes069
87R:R:W353 R:R:W386 75.530611.25YesYes2199
88R:R:F345 R:R:W386 75.49615.01YesYes089
89R:R:F345 R:R:T393 71.73453.89YesNo089
90R:R:T393 R:R:Y344 71.64383.75NoYes099
91R:R:Y344 R:R:Y412 69.34476.95YesYes996
92R:R:Y412 R:R:Y489 67.82415.96YesYes964
93R:R:K533 R:R:Y489 67.37369.55YesYes094
94R:R:E492 R:R:K533 23.10696.75NoYes099
95R:R:E492 R:R:F530 21.75598.16NoYes097
96R:R:F245 R:R:F530 43.307210.72YesYes487
97R:R:F245 R:R:Y244 53.63294.13YesNo084
98R:R:M243 R:R:Y244 50.706711.97YesNo074
99R:R:K533 R:R:Y534 43.81234.78YesYes098
100R:R:F530 R:R:Y534 21.77584.13YesYes478
101R:R:L407 R:R:Y534 21.77058.21NoYes488
102R:R:F245 R:R:L407 21.666215.83YesNo488
103R:R:M243 R:R:P233 45.4426.71YesYes1477
104R:R:L214 R:R:P233 23.40848.21NoYes077
105R:R:L214 R:R:Y324 23.08054.69NoYes072
106R:R:E235 R:R:Y324 21.11195.61YesYes842
107R:R:E235 R:R:R325 40.89963.49YesYes844
108R:R:D311 R:R:R325 36.94447.15YesYes864
109R:R:D311 R:R:V314 29.04784.38YesNo068
110R:R:G404 R:R:V314 27.72963.68NoNo098
111R:R:D403 R:R:G404 21.79513.35NoNo099
112R:R:D403 R:R:Q329 20.475713.05NoYes097
113R:R:Q329 R:R:Y222 17.836413.53YesYes076
114R:R:G241 R:R:P233 21.75994.06NoYes087
115R:R:G241 R:R:R238 21.4324.5NoNo084
116R:R:E235 R:R:R238 21.103812.79YesNo844
117R:R:F245 R:R:F527 10.63386.43YesYes486
118B:B:D76 B:B:H54 14.12257.56YesYes299
119A:A:C237 A:A:F238 59.14875.59NoYes789
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9EW2
Class F
SubFamily Protein
Type Frizzled
SubType FZD7
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.2
Date 2024-10-02
D.O.I. doi.org/10.1038/s41467-024-51664-4
Net Summary
Imin 3.64
Number of Linked Nodes 920
Number of Links 1098
Number of Hubs 175
Number of Links mediated by Hubs 643
Number of Communities 39
Number of Nodes involved in Communities 269
Number of Links involved in Communities 373
Path Summary
Number Of Nodes in MetaPath 120
Number Of Links MetaPath 119
Number of Shortest Paths 4734180
Length Of Smallest Path 3
Average Path Length 56.6725
Length of Longest Path 93
Minimum Path Strength 1.405
Average Path Strength 7.76505
Maximum Path Strength 27.645
Minimum Path Correlation 0.7
Average Path Correlation 0.995378
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 34.8175
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 47.3593
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• molecular transducer activity   • transmembrane signaling receptor activity   • signaling receptor activity   • Wnt receptor activity   • G protein-coupled receptor activity   • protein binding   • binding   • PDZ domain binding   • protein domain specific binding   • signaling receptor binding   • G protein-coupled receptor binding   • frizzled binding   • ion binding   • phosphatidylinositol-4,5-bisphosphate binding   • anion binding   • phosphatidylinositol bisphosphate binding   • phospholipid binding   • lipid binding   • phosphatidylinositol phosphate binding   • phosphatidylinositol binding   • small molecule binding   • Wnt-protein binding   • cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • cell surface receptor signaling pathway   • response to stimulus   • regulation of Wnt signaling pathway   • signaling   • regulation of canonical Wnt signaling pathway   • canonical Wnt signaling pathway   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of signaling   • regulation of cellular process   • cell surface receptor signaling pathway   • response to stimulus   • regulation of Wnt signaling pathway   • signaling   • regulation of canonical Wnt signaling pathway   • canonical Wnt signaling pathway   • biological regulation   • regulation of signal transduction   • cell communication   • regulation of response to stimulus   • regulation of cell communication   • cellular process   • signal transduction   • Wnt signaling pathway   • wound healing   • cell population proliferation   • positive regulation of cell population proliferation   • positive regulation of epithelial cell proliferation   • positive regulation of biological process   • response to stress   • regulation of cell population proliferation   • regulation of epithelial cell proliferation   • response to wounding   • epithelial cell proliferation   • positive regulation of cellular process   • positive regulation of epithelial cell proliferation involved in wound healing   • multicellular organismal process   • regulation of developmental process   • cellular developmental process   • negative regulation of biological process   • negative regulation of muscle cell differentiation   • regulation of cell differentiation   • regulation of striated muscle cell differentiation   • regulation of cardiac muscle cell differentiation   • muscle cell differentiation   • striated muscle tissue development   • muscle structure development   • multicellular organism development   • cell differentiation   • negative regulation of cardiac muscle cell differentiation   • anatomical structure development   • negative regulation of cellular process   • negative regulation of cell differentiation   • regulation of multicellular organismal process   • muscle tissue development   • negative regulation of cardiocyte differentiation   • system development   • developmental process   • heart development   • cardiac muscle tissue development   • negative regulation of developmental process   • negative regulation of striated muscle cell differentiation   • animal organ development   • cardiac muscle cell differentiation   • tissue development   • cardiocyte differentiation   • circulatory system development   • regulation of muscle cell differentiation   • regulation of cardiocyte differentiation   • striated muscle cell differentiation   • negative regulation of multicellular organismal process   • non-canonical Wnt signaling pathway   • cell adhesion   • substrate adhesion-dependent cell spreading   • cell-substrate adhesion   • response to lipid   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • response to retinoic acid   • cellular response to chemical stimulus   • cellular response to retinoic acid   • response to chemical   • cellular response to lipid   • nervous system development   • generation of neurons   • neurogenesis   • neuron differentiation   • hemopoiesis   • cell activation   • cell development   • mononuclear cell differentiation   • lymphocyte activation   • lymphocyte differentiation   • leukocyte activation   • T cell differentiation in thymus   • T cell activation   • immune system process   • T cell differentiation   • leukocyte differentiation   • positive regulation of cell communication   • positive regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of JNK cascade   • regulation of intracellular signal transduction   • JNK cascade   • intracellular signaling cassette   • positive regulation of MAPK cascade   • regulation of JNK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • MAPK cascade   • positive regulation of signaling   • Wnt signaling pathway, planar cell polarity pathway   • RNA metabolic process   • regulation of primary metabolic process   • nucleobase-containing compound metabolic process   • RNA biosynthetic process   • nucleic acid biosynthetic process   • DNA-templated transcription   • regulation of RNA metabolic process   • regulation of nucleobase-containing compound metabolic process   • regulation of RNA biosynthetic process   • regulation of biosynthetic process   • primary metabolic process   • regulation of macromolecule metabolic process   • nucleobase-containing compound biosynthetic process   • gene expression   • macromolecule biosynthetic process   • nucleic acid metabolic process   • regulation of gene expression   • biosynthetic process   • metabolic process   • regulation of macromolecule biosynthetic process   • regulation of DNA-templated transcription   • macromolecule metabolic process   • regulation of metabolic process   • maintenance of cell number   • stem cell population maintenance   • regulation of cell-substrate adhesion   • regulation of cell adhesion   • negative regulation of cell adhesion   • negative regulation of cell-substrate adhesion   • positive regulation of DNA-templated transcription   • positive regulation of macromolecule biosynthetic process   • positive regulation of metabolic process   • positive regulation of biosynthetic process   • positive regulation of macromolecule metabolic process   • positive regulation of RNA metabolic process   • positive regulation of RNA biosynthetic process   • positive regulation of phosphorylation   • positive regulation of phosphorus metabolic process   • phosphorylation   • positive regulation of phosphate metabolic process   • phosphate-containing compound metabolic process   • regulation of phosphorus metabolic process   • regulation of phosphorylation   • phosphorus metabolic process   • somatic stem cell division   • stem cell division   • cell division   • negative regulation of cell fate specification   • embryo development   • regulation of ectodermal cell fate specification   • negative regulation of cell fate commitment   • ectoderm development   • ectodermal cell differentiation   • negative regulation of ectodermal cell fate specification   • formation of primary germ layer   • ectodermal cell fate commitment   • regulation of cell fate commitment   • embryonic morphogenesis   • ectodermal cell fate specification   • cell fate specification   • gastrulation   • ectoderm formation   • cell fate commitment involved in formation of primary germ layer   • anatomical structure morphogenesis   • regulation of cell fate specification   • anatomical structure formation involved in morphogenesis   • cell fate commitment   • epithelium development   • mesenchymal to epithelial transition   • epithelial cell differentiation   • tissue regeneration   • skeletal muscle tissue regeneration   • developmental growth   • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration   • growth   • regeneration   • cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • organelle   • intracellular membrane-bounded organelle   • endosome membrane   • endosome   • intracellular vesicle   • recycling endosome   • endomembrane system
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • cell periphery   • plasma membrane   • membrane-bounded organelle   • intracellular organelle   • intracellular anatomical structure   • organelle   • intracellular membrane-bounded organelle   • endosome membrane   • endosome   • intracellular vesicle   • recycling endosome   • endomembrane system   • cytoplasmic vesicle membrane   • bounding membrane of organelle   • recycling endosome membrane   • vesicle membrane   • cytoplasmic vesicle   • cytoplasm   • vesicle   • organelle membrane   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • extracellular membrane-bounded organelle   • synapse   • cell junction   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • lysosomal membrane   • lysosome   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • trans-Golgi network
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9EW2_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRILHT SGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNLFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTENARRIF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9EW2_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9EW2_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO75084
Sequence
>9EW2_Chain_R
CPRQLKVPP YLGYRFLGE RDCGAPCEP GRANGLMYF KEEERRFAR 
LWVGVWSVL CCASTLFTV LTYLVDMRR FSYPERPII FLSGCYFMV 
AVAHVAGFL LEDRAVCVE RFSDDGYRT VAQGTKKEG CTILFMVLY 
FFGMASSIW WVILSLTWF LAAGMKWGH EAIEANSQY FHLAAWAVP 
AVKTITILA MGQVDGDLL SGVCYVGLS SVDALRGFV LAPLFVYLF 
IGTSFLLAG FVSLFRIRT IMKHDGTKT EKLEKLMVR IGVFSVLYT 
VPATIVLAC YFYEQAFRE HWERTWLLQ TCDFTVFMI KYLMTMIVG 
ITTGFWIWS GKTLQSWRR FYH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YY8FProteinFrizzledFZD7Homo sapiens--Gs/β1/γ23.222024-04-24doi.org/10.1038/s41422-021-00525-6
8YY8 (No Gprot) FProteinFrizzledFZD7Homo sapiens--3.222024-04-24doi.org/10.1038/s41422-021-00525-6
9EPOFProteinFrizzledFZD7Homo sapiens---1.92024-10-02doi.org/10.1038/s41467-024-51664-4
9EW2 (No Gprot) FProteinFrizzledFZD7Homo sapiens--3.22024-10-02doi.org/10.1038/s41467-024-51664-4




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