psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C210	R:R:C230	7.28	No	No	0	9	9
2	R:R:L214	R:R:P211	6.57	No	No	0	7	6
3	R:R:D322	R:R:R212	9.53	No	No	0	4	3
4	R:R:Q213	R:R:Y324	24.8	No	No	0	4	2
5	R:R:L214	R:R:P233	4.93	No	Yes	0	7	7
6	R:R:L214	R:R:Y324	4.69	No	No	0	7	2
7	R:R:P217	R:R:V216	3.53	No	No	0	5	5
8	R:R:L220	R:R:V216	4.47	Yes	No	10	3	5
9	R:R:V216	R:R:Y222	13.88	No	Yes	10	5	6
10	R:R:F319	R:R:P217	14.45	Yes	No	0	4	5
11	R:R:D229	R:R:P218	4.83	No	No	0	5	2
12	R:R:L220	R:R:Y219	3.52	Yes	No	0	3	3
13	R:R:L220	R:R:Y222	10.55	Yes	Yes	10	3	6
14	R:R:F319	R:R:L220	3.65	Yes	Yes	0	4	3
15	R:R:V316	R:R:Y222	3.79	No	Yes	0	5	6
16	R:R:Q329	R:R:Y222	10.15	Yes	Yes	0	7	6
17	R:R:G226	R:R:R223	6	No	No	0	5	4
18	R:R:F224	R:R:L225	15.83	Yes	Yes	6	6	6
19	R:R:C230	R:R:F224	4.19	No	Yes	0	9	6
20	R:R:F224	R:R:G231	4.52	Yes	No	0	6	8
21	R:R:A232	R:R:F224	8.32	No	Yes	0	5	6
22	R:R:F224	R:R:M243	4.98	Yes	Yes	6	6	7
23	R:R:F224	R:R:W503	5.01	Yes	Yes	6	6	5
24	R:R:E500	R:R:L225	6.63	No	Yes	0	5	6
25	R:R:L225	R:R:W503	4.56	Yes	Yes	6	6	5
26	R:R:C230	R:R:E227	4.56	No	No	0	9	5
27	R:R:D229	R:R:R228	8.34	No	No	0	5	2
28	R:R:G241	R:R:P233	4.06	No	Yes	0	8	7
29	R:R:M243	R:R:P233	5.03	Yes	Yes	6	7	7
30	R:R:P233	R:R:W503	5.4	Yes	Yes	6	7	5
31	R:R:C234	R:R:D311	6.22	No	Yes	5	9	6
32	R:R:C234	R:R:C315	7.28	No	No	5	9	9
33	R:R:C234	R:R:R325	12.54	No	Yes	5	9	4
34	R:R:E235	R:R:R238	18.61	No	No	0	4	4
35	R:R:E235	R:R:R318	6.98	No	No	0	4	4
36	R:R:E235	R:R:R325	3.49	No	Yes	0	4	4
37	R:R:G241	R:R:R238	4.5	No	No	0	8	4
38	R:R:R238	R:R:Y324	18.52	No	No	0	4	2
39	R:R:N240	R:R:T507	11.7	No	No	0	2	4
40	R:R:L242	R:R:R250	3.64	No	Yes	0	5	6
41	R:R:M243	R:R:Y244	11.97	Yes	No	0	7	4
42	R:R:M243	R:R:W503	17.45	Yes	Yes	6	7	5
43	R:R:F245	R:R:Y244	4.13	Yes	No	0	8	4
44	R:R:W499	R:R:Y244	3.86	Yes	No	0	9	4
45	R:R:E249	R:R:F245	4.66	No	Yes	1	6	8
46	R:R:F245	R:R:L407	18.27	Yes	Yes	1	8	8
47	R:R:F245	R:R:F527	8.57	Yes	Yes	1	8	6
48	R:R:F245	R:R:F530	7.5	Yes	Yes	1	8	7
49	R:R:E249	R:R:K246	4.05	No	No	0	6	4
50	R:R:E247	R:R:R251	11.63	No	No	0	2	3
51	R:R:E249	R:R:F527	12.83	No	Yes	1	6	6
52	R:R:R250	R:R:R254	8.53	Yes	No	5	6	6
53	R:R:D311	R:R:R250	9.53	Yes	Yes	5	6	6
54	R:R:L406	R:R:R250	3.64	No	Yes	0	5	6
55	R:R:E310	R:R:R254	16.28	No	No	0	7	6
56	R:R:D311	R:R:R254	8.34	Yes	No	5	6	6
57	R:R:W256	R:R:W260	19.68	No	Yes	2	8	5
58	R:R:M531	R:R:W256	3.49	Yes	No	0	8	8
59	R:R:L535	R:R:W256	6.83	No	No	2	7	8
60	R:R:H303	R:R:V257	4.15	Yes	No	0	6	7
61	R:R:V257	R:R:Y534	5.05	No	Yes	0	7	8
62	R:R:F307	R:R:G258	6.02	No	No	0	5	5
63	R:R:L535	R:R:W260	6.83	No	Yes	2	7	5
64	R:R:M538	R:R:W260	4.65	No	Yes	0	8	5
65	R:R:H303	R:R:S261	4.18	Yes	No	0	6	8
66	R:R:A300	R:R:C264	3.61	No	No	0	8	9
67	R:R:C265	R:R:F297	5.59	No	Yes	0	5	5
68	R:R:I542	R:R:S267	4.64	No	No	0	8	9
69	R:R:S293	R:R:T268	4.8	No	No	0	8	9
70	R:R:F297	R:R:T268	6.49	Yes	No	0	5	9
71	R:R:L269	R:R:L273	5.54	No	No	0	6	6
72	R:R:F297	R:R:L269	4.87	Yes	No	0	5	6
73	R:R:F270	R:R:T274	7.78	No	Yes	3	7	9
74	R:R:F270	R:R:W557	8.02	No	Yes	3	7	9
75	R:R:S293	R:R:T271	9.59	No	No	0	8	9
76	R:R:I548	R:R:T271	6.08	Yes	No	0	8	9
77	R:R:F282	R:R:T274	3.89	Yes	Yes	3	9	9
78	R:R:I548	R:R:T274	4.56	Yes	Yes	3	8	9
79	R:R:T274	R:R:W557	12.13	Yes	Yes	3	9	9
80	R:R:M279	R:R:Y275	5.99	No	No	0	6	8
81	R:R:I290	R:R:Y275	7.25	No	No	0	8	8
82	R:R:V277	R:R:W557	7.36	No	Yes	3	8	9
83	R:R:F560	R:R:V277	10.49	No	No	3	6	8
84	R:R:D278	R:R:R280	3.57	Yes	No	0	9	4
85	R:R:D278	R:R:R281	10.72	Yes	Yes	9	9	9
86	R:R:D278	R:R:S556	7.36	Yes	No	9	9	8
87	R:R:D278	R:R:R559	9.53	Yes	No	9	9	4
88	R:R:K552	R:R:R281	7.43	No	Yes	0	9	9
89	R:R:R281	R:R:S556	3.95	Yes	No	9	9	8
90	R:R:E286	R:R:F282	11.66	No	Yes	0	9	9
91	R:R:F282	R:R:I290	10.05	Yes	No	0	9	8
92	R:R:F282	R:R:I548	3.77	Yes	Yes	3	9	8
93	R:R:P285	R:R:S283	7.13	No	No	0	9	6
94	R:R:H371	R:R:S283	6.97	No	No	0	7	6
95	R:R:R287	R:R:Y284	7.2	No	Yes	11	9	9
96	R:R:I374	R:R:Y284	3.63	Yes	Yes	0	9	9
97	R:R:E375	R:R:Y284	13.47	No	Yes	11	7	9
98	R:R:S378	R:R:Y284	6.36	No	Yes	0	8	9
99	R:R:F381	R:R:Y284	7.22	No	Yes	0	8	9
100	R:R:E286	R:R:W547	6.54	No	Yes	0	9	9
101	R:R:E375	R:R:R287	10.47	No	No	11	7	9
102	R:R:P288	R:R:W353	5.4	No	Yes	0	8	9
103	R:R:L357	R:R:P288	6.57	No	No	0	9	8
104	R:R:P288	R:R:T360	3.5	No	No	0	8	8
105	R:R:I289	R:R:L357	5.71	No	No	0	9	9
106	R:R:I289	R:R:T544	6.08	No	No	0	9	8
107	R:R:F291	R:R:W353	18.04	No	Yes	8	8	9
108	R:R:F291	R:R:H382	10.18	No	No	8	8	9
109	R:R:L292	R:R:Y296	4.69	No	Yes	2	8	8
110	R:R:L292	R:R:Y478	8.21	No	Yes	2	8	8
111	R:R:L292	R:R:T544	4.42	No	No	0	8	8
112	R:R:S293	R:R:T544	4.8	No	No	0	8	8
113	R:R:C295	R:R:S350	5.16	No	No	0	9	8
114	R:R:S350	R:R:Y296	16.53	No	Yes	0	8	8
115	R:R:Y296	R:R:Y478	9.93	Yes	Yes	2	8	8
116	R:R:V540	R:R:Y296	6.31	No	Yes	2	8	8
117	R:R:G541	R:R:Y296	4.35	No	Yes	0	9	8
118	R:R:F297	R:R:M298	3.73	Yes	No	0	5	6
119	R:R:F297	R:R:V301	7.87	Yes	No	0	5	4
120	R:R:F346	R:R:M298	17.42	No	No	0	9	6
121	R:R:L343	R:R:V299	4.47	No	No	0	6	8
122	R:R:H303	R:R:L343	5.14	Yes	No	0	6	6
123	R:R:H303	R:R:V410	4.15	Yes	No	0	6	7
124	R:R:L309	R:R:R312	6.07	No	No	0	6	3
125	R:R:A313	R:R:L309	4.73	No	No	0	6	6
126	R:R:C315	R:R:D311	4.67	No	Yes	5	9	6
127	R:R:D311	R:R:R325	8.34	Yes	Yes	5	6	4
128	R:R:G404	R:R:V314	3.68	No	No	0	9	8
129	R:R:G409	R:R:V314	3.68	No	No	0	9	8
130	R:R:C315	R:R:R325	5.57	No	Yes	5	9	4
131	R:R:F319	R:R:V316	3.93	Yes	No	0	4	5
132	R:R:F319	R:R:T326	5.19	Yes	No	0	4	5
133	R:R:D322	R:R:S320	5.89	No	No	0	4	2
134	R:R:L406	R:R:V327	8.94	No	No	0	5	7
135	R:R:D403	R:R:Q329	7.83	Yes	Yes	0	9	7
136	R:R:T331	R:R:T337	4.71	No	No	0	7	8
137	R:R:C336	R:R:K333	4.85	No	No	0	9	6
138	R:R:C336	R:R:C411	7.28	No	No	0	9	9
139	R:R:F340	R:R:Y344	5.16	Yes	Yes	1	9	9
140	R:R:F340	R:R:I396	10.05	Yes	Yes	1	9	7
141	R:R:F340	R:R:V402	11.8	Yes	No	0	9	8
142	R:R:F340	R:R:V413	6.55	Yes	Yes	1	9	9
143	R:R:L397	R:R:M341	5.65	No	Yes	0	8	8
144	R:R:L343	R:R:Y412	8.21	No	Yes	0	6	6
145	R:R:M348	R:R:Y344	11.97	No	Yes	0	8	9
146	R:R:K392	R:R:Y344	4.78	No	Yes	0	6	9
147	R:R:T393	R:R:Y344	3.75	No	Yes	0	9	9
148	R:R:I396	R:R:Y344	8.46	Yes	Yes	1	7	9
149	R:R:Y344	R:R:Y412	4.96	Yes	Yes	1	9	6
150	R:R:V413	R:R:Y344	3.79	Yes	Yes	1	9	9
151	R:R:F424	R:R:Y344	5.16	Yes	Yes	1	8	9
152	R:R:F345	R:R:F346	9.65	Yes	No	0	8	9
153	R:R:F345	R:R:W386	7.02	Yes	Yes	0	8	9
154	R:R:F345	R:R:P389	5.78	Yes	No	0	8	9
155	R:R:G347	R:R:S350	3.71	No	No	0	7	8
156	R:R:L429	R:R:M348	4.24	No	No	0	8	8
157	R:R:S351	R:R:Y432	3.82	No	No	0	8	6
158	R:R:I352	R:R:Y432	12.09	No	No	0	6	6
159	R:R:I356	R:R:W353	9.4	No	Yes	0	6	9
160	R:R:H382	R:R:W353	9.52	No	Yes	8	9	9
161	R:R:A385	R:R:W353	7.78	No	Yes	8	9	9
162	R:R:W353	R:R:W386	8.43	Yes	Yes	8	9	9
163	R:R:S358	R:R:W354	6.18	No	No	0	8	9
164	R:R:W354	R:R:Y478	38.58	No	Yes	0	9	8
165	R:R:V355	R:R:Y432	3.79	No	No	0	8	6
166	R:R:G436	R:R:S358	3.71	No	No	0	9	8
167	R:R:L440	R:R:S358	7.51	No	No	0	8	8
168	R:R:F381	R:R:L359	3.65	No	No	0	8	6
169	R:R:F439	R:R:L359	9.74	No	No	0	8	6
170	R:R:G443	R:R:W361	4.22	No	Yes	0	9	9
171	R:R:F444	R:R:W361	9.02	No	Yes	4	8	9
172	R:R:I471	R:R:W361	8.22	Yes	Yes	4	9	9
173	R:R:F362	R:R:M367	3.73	No	No	0	8	5
174	R:R:F362	R:R:F439	7.5	No	No	0	8	8
175	R:R:I374	R:R:L363	5.71	Yes	No	0	9	9
176	R:R:G366	R:R:S446	3.71	No	No	0	7	8
177	R:R:M367	R:R:W369	5.82	No	No	0	5	9
178	R:R:I374	R:R:W369	7.05	Yes	No	0	9	9
179	R:R:N377	R:R:Y380	4.65	No	No	0	6	8
180	R:R:H382	R:R:W386	5.29	No	Yes	8	9	9
181	R:R:A385	R:R:W386	6.48	No	Yes	8	9	9
182	R:R:P389	R:R:V388	3.53	No	No	0	9	5
183	R:R:F424	R:R:T395	3.89	Yes	No	0	8	5
184	R:R:I396	R:R:V413	9.22	Yes	Yes	1	7	9
185	R:R:F424	R:R:I396	13.82	Yes	Yes	1	8	7
186	R:R:M399	R:R:Q401	5.44	No	No	0	5	7
187	R:R:A420	R:R:Q401	6.06	No	No	0	5	7
188	R:R:D403	R:R:L415	5.43	Yes	No	0	9	7
189	R:R:D403	R:R:S416	8.83	Yes	No	0	9	5
190	R:R:D405	R:R:S408	8.83	No	No	0	9	8
191	R:R:D405	R:R:L415	8.14	No	No	0	9	7
192	R:R:F527	R:R:L407	6.09	Yes	Yes	1	6	8
193	R:R:F530	R:R:L407	3.65	Yes	Yes	1	7	8
194	R:R:L407	R:R:Y534	4.69	Yes	Yes	0	8	8
195	R:R:S408	R:R:Y534	7.63	No	Yes	0	8	8
196	R:R:L415	R:R:Y412	3.52	No	Yes	0	7	6
197	R:R:V425	R:R:Y412	7.57	No	Yes	1	8	6
198	R:R:Y412	R:R:Y489	4.96	Yes	Yes	1	6	4
199	R:R:F424	R:R:V413	3.93	Yes	Yes	1	8	9
200	R:R:G414	R:R:L421	5.13	No	No	0	9	9
201	R:R:R422	R:R:V418	7.85	Yes	No	0	6	4
202	R:R:L421	R:R:V425	4.47	No	No	1	9	8
203	R:R:L421	R:R:Y489	3.52	No	Yes	1	9	4
204	R:R:Q493	R:R:R422	12.85	No	Yes	0	6	6
205	R:R:V425	R:R:Y489	8.83	No	Yes	1	8	4
206	R:R:F430	R:R:L486	4.87	No	Yes	0	3	8
207	R:R:A482	R:R:L433	4.73	No	No	0	8	8
208	R:R:F434	R:R:S438	7.93	No	No	0	3	5
209	R:R:L440	R:R:S475	6.01	No	No	0	8	8
210	R:R:F444	R:R:I471	5.02	No	Yes	4	8	9
211	R:R:F444	R:R:G472	4.52	No	No	0	8	9
212	R:R:L447	R:R:L464	4.15	No	No	4	8	8
213	R:R:L447	R:R:M468	7.07	No	Yes	4	8	9
214	R:R:F448	R:R:R451	4.28	No	No	4	6	9
215	R:R:F448	R:R:M468	8.71	No	Yes	4	6	9
216	R:R:E465	R:R:R451	12.79	No	No	0	8	9
217	R:R:M468	R:R:R451	4.96	Yes	No	4	9	9
218	R:R:M454	R:R:T459	12.04	No	No	0	8	6
219	R:R:M454	R:R:T461	4.52	No	No	0	8	8
220	R:R:D457	R:R:H456	6.3	No	No	0	6	5
221	R:R:E462	R:R:K460	12.15	No	No	0	6	7
222	R:R:E465	R:R:T461	8.47	No	No	0	8	8
223	R:R:L464	R:R:M468	4.24	No	Yes	4	8	9
224	R:R:I471	R:R:L467	7.14	Yes	No	0	9	9
225	R:R:R470	R:R:W547	16.99	No	Yes	0	9	9
226	R:R:I471	R:R:W547	3.52	Yes	Yes	0	9	9
227	R:R:G472	R:R:S475	3.71	No	No	0	9	8
228	R:R:F474	R:R:W547	10.02	No	Yes	0	9	9
229	R:R:V540	R:R:Y478	6.31	No	Yes	2	8	8
230	R:R:P481	R:R:V480	3.53	Yes	No	0	9	8
231	R:R:M536	R:R:P481	6.71	Yes	Yes	2	8	9
232	R:R:I539	R:R:P481	6.77	No	Yes	2	7	9
233	R:R:P481	R:R:V540	3.53	Yes	No	2	9	8
234	R:R:I484	R:R:M536	7.29	No	Yes	0	4	8
235	R:R:C488	R:R:K533	6.47	No	Yes	0	8	9
236	R:R:E492	R:R:Y489	5.61	Yes	Yes	1	9	4
237	R:R:K533	R:R:Y489	5.97	Yes	Yes	1	9	4
238	R:R:F490	R:R:Q493	9.37	No	No	0	3	6
239	R:R:F495	R:R:Y491	8.25	No	Yes	7	4	9
240	R:R:W499	R:R:Y491	10.61	Yes	Yes	7	9	9
241	R:R:D526	R:R:Y491	5.75	No	Yes	7	5	9
242	R:R:V529	R:R:Y491	10.09	No	Yes	7	7	9
243	R:R:E492	R:R:R496	5.82	Yes	No	0	9	7
244	R:R:E492	R:R:F530	12.83	Yes	Yes	1	9	7
245	R:R:E492	R:R:K533	6.75	Yes	Yes	1	9	9
246	R:R:F495	R:R:W499	5.01	No	Yes	7	4	9
247	R:R:E497	R:R:R501	6.98	No	No	0	2	2
248	R:R:H498	R:R:T502	6.85	No	No	0	1	4
249	R:R:Q506	R:R:T502	5.67	No	No	0	3	4
250	R:R:T507	R:R:W503	10.92	No	Yes	0	4	5
251	R:R:D526	R:R:T528	5.78	No	No	0	5	6
252	R:R:D526	R:R:V529	5.84	No	No	7	5	7
253	R:R:F527	R:R:M531	14.93	Yes	Yes	0	6	8
254	R:R:F530	R:R:K533	3.72	Yes	Yes	1	7	9
255	R:R:M531	R:R:Y534	3.59	Yes	Yes	0	8	8
256	R:R:K533	R:R:Y534	4.78	Yes	Yes	0	9	8
257	R:R:L535	R:R:M536	4.24	No	Yes	2	7	8
258	R:R:I539	R:R:M536	4.37	No	Yes	2	7	8
259	R:R:I539	R:R:I542	4.42	No	No	0	7	8
260	R:R:R559	R:R:S556	6.59	No	No	9	4	8
261	R:R:F560	R:R:W557	4.01	No	Yes	3	6	9
262	R:R:W557	R:R:Y561	11.58	Yes	No	3	9	4
263	R:R:H562	R:R:R558	7.9	No	No	0	3	5
264	R:R:F560	R:R:Y561	4.13	No	No	3	6	4
265	R:R:H562	R:R:Y561	5.44	No	No	0	3	4
266	R:R:L263	R:R:W260	3.42	No	Yes	0	5	5
267	R:R:C411	R:R:V314	3.42	No	No	0	9	8
268	R:R:A420	R:R:S417	3.42	No	No	0	5	7
269	R:R:I352	R:R:P389	3.39	No	No	0	6	9
270	R:R:C264	R:R:T268	3.38	No	No	0	9	9
271	R:R:M348	R:R:P428	3.35	No	No	0	8	9
272	R:R:D403	R:R:G404	3.35	Yes	No	0	9	9
273	R:R:G323	R:R:Q213	3.29	No	No	0	2	4
274	R:R:G330	R:R:Q329	3.29	No	Yes	0	7	7
275	R:R:L242	R:R:P236	3.28	No	No	0	5	5
276	R:R:F252	R:R:F527	3.22	No	Yes	0	6	6
277	R:R:A253	R:R:M531	3.22	No	Yes	0	7	8
278	R:R:S550	R:R:T553	3.2	No	No	0	9	9
279	R:R:T483	R:R:V480	3.17	No	No	0	5	8
280	R:R:A387	R:R:L383	3.15	No	No	0	7	5
281	R:R:T437	R:R:T479	3.14	No	No	0	7	8
282	R:R:I435	R:R:V431	3.07	No	No	0	5	5
283	R:R:K552	R:R:S550	3.06	No	No	0	9	9
284	R:R:M298	R:R:V342	3.04	No	No	0	6	5
285	R:R:I374	R:R:T360	3.04	Yes	No	0	9	8
286	R:R:I532	R:R:T528	3.04	No	No	0	6	6
287	R:R:I548	R:R:T553	3.04	Yes	No	0	8	9
288	R:R:M341	R:R:T337	3.01	Yes	No	0	8	8
289	R:R:M341	R:R:T393	3.01	Yes	No	0	8	9
290	R:R:M538	R:R:T537	3.01	No	No	0	8	6
291	R:R:L477	R:R:V473	2.98	No	No	0	8	6
292	R:R:L433	R:R:T437	2.95	No	No	0	8	7
293	R:R:L441	R:R:T437	2.95	No	No	0	6	7
294	R:R:L477	R:R:T543	2.95	No	No	0	8	9
295	R:R:I450	R:R:M454	2.92	No	No	0	8	8
296	R:R:K332	R:R:L220	2.82	No	Yes	0	6	3
297	R:R:A390	R:R:F345	2.77	No	Yes	0	8	8
298	R:R:A442	R:R:F362	2.77	No	No	0	7	8
299	R:R:A420	R:R:F424	2.77	No	Yes	0	5	8
300	R:R:A494	R:R:F495	2.77	No	No	0	4	4
301	R:R:L426	R:R:Q493	2.66	No	No	0	7	6
302	R:R:R496	R:R:V418	2.62	No	No	0	7	4
303	R:R:R449	R:R:V445	2.62	No	No	0	8	6
304	R:R:A349	R:R:W386	2.59	No	Yes	0	9	9
305	R:R:A373	R:R:W369	2.59	No	No	0	8	9
306	R:R:F474	R:R:T543	2.59	No	No	0	9	9
307	R:R:V485	R:R:Y489	2.52	No	Yes	0	8	4
308	R:R:F439	R:R:I435	2.51	No	No	0	8	5
309	R:R:F307	R:R:L255	2.44	No	No	0	5	4
310	R:R:F381	R:R:N377	2.42	No	No	0	8	6
311	R:R:D419	R:R:R422	2.38	No	Yes	0	4	6
312	R:R:L447	R:R:W361	2.28	No	Yes	4	8	9
313	R:R:F474	R:R:F546	2.14	No	No	0	9	7
314	R:R:H498	R:R:W499	2.12	No	Yes	0	1	9
315	R:R:P217	R:R:P218	1.95	No	No	0	5	2
316	R:R:A365	R:R:G366	1.95	No	No	0	9	7
317	R:R:A365	R:R:G443	1.95	No	No	0	9	9
318	R:R:A427	R:R:P428	1.87	No	No	0	6	9
319	R:R:G258	R:R:S261	1.86	No	No	0	5	8
320	R:R:G545	R:R:S267	1.86	No	No	0	8	9
321	R:R:G323	R:R:S320	1.86	No	No	0	2	2
322	R:R:G551	R:R:S550	1.86	No	No	0	6	9
323	R:R:G294	R:R:V272	1.84	No	No	0	5	7
324	R:R:G306	R:R:V410	1.84	No	No	0	9	7
325	R:R:G400	R:R:T331	1.82	No	No	0	7	7
326	R:R:G335	R:R:I338	1.76	No	No	0	4	6
327	R:R:C265	R:R:V304	1.71	No	No	0	5	5
328	R:R:A302	R:R:V342	1.7	No	No	0	7	5
329	R:R:A302	R:R:V410	1.7	No	No	0	7	7
330	R:R:A328	R:R:V316	1.7	No	No	0	6	5
331	R:R:A384	R:R:V388	1.7	No	No	0	6	5
332	R:R:I374	R:R:P285	1.69	Yes	No	0	9	9
333	R:R:D229	R:R:G221	1.68	No	No	0	5	3
334	R:R:E247	R:R:G237	1.64	No	No	0	2	3
335	R:R:E334	R:R:G335	1.64	No	No	0	6	4
336	R:R:A364	R:R:I374	1.62	No	Yes	0	8	9
337	R:R:V469	R:R:V473	1.6	No	No	0	7	6
338	R:R:V476	R:R:V480	1.6	No	No	0	7	8
339	R:R:C508	R:R:L504	1.59	No	No	0	9	4
340	R:R:A302	R:R:L339	1.58	No	No	0	7	8
341	R:R:A305	R:R:L309	1.58	No	No	0	5	6
342	R:R:A305	R:R:L339	1.58	No	No	0	5	8
343	R:R:A313	R:R:L339	1.58	No	No	0	6	8
344	R:R:E247	R:R:P236	1.57	No	No	0	2	5
345	R:R:T479	R:R:T483	1.57	No	No	0	8	5
346	R:R:G423	R:R:R422	1.5	No	Yes	0	4	6
347	R:R:L263	R:R:V259	1.49	No	No	0	5	5
348	R:R:L276	R:R:V272	1.49	No	No	0	6	7
349	R:R:L308	R:R:V304	1.49	No	No	0	4	5
350	R:R:I338	R:R:M341	1.46	No	Yes	0	6	8
351	R:R:I450	R:R:K368	1.45	No	No	0	8	9
352	R:R:D457	R:R:T459	1.45	No	No	0	6	6
353	R:R:I394	R:R:L397	1.43	No	No	0	7	8
354	R:R:D457	R:R:I453	1.4	No	No	0	6	6
355	R:R:L225	R:R:L504	1.38	Yes	No	0	6	4
356	R:R:L273	R:R:L276	1.38	No	No	0	6	6
357	R:R:L426	R:R:L486	1.38	No	Yes	0	7	8
358	R:R:L429	R:R:L486	1.38	No	Yes	0	8	8
359	R:R:L433	R:R:L486	1.38	No	Yes	0	8	8
360	R:R:Q329	R:R:R223	1.17	Yes	No	0	7	4
361	R:R:Q555	R:R:R281	1.17	No	Yes	0	4	9
362	R:R:E317	R:R:R325	1.16	No	Yes	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:L220	5.002	5	10	3
2	R:R:Y222	9.5925	4	10	6
3	R:R:F224	7.14167	6	6	6
4	R:R:L225	7.1	4	6	6
5	R:R:P233	4.855	4	6	7
6	R:R:M243	9.8575	4	6	7
7	R:R:F245	8.626	5	1	8
8	R:R:R250	6.335	4	5	6
9	R:R:W260	8.645	4	2	5
10	R:R:T274	7.09	4	3	9
11	R:R:D278	7.795	4	9	9
12	R:R:R281	5.8175	4	9	9
13	R:R:F282	7.3425	4	3	9
14	R:R:Y284	7.576	5	11	9
15	R:R:Y296	8.362	5	2	8
16	R:R:F297	5.71	5	0	5
17	R:R:H303	4.405	4	0	6
18	R:R:D311	7.42	5	5	6
19	R:R:F319	6.805	4	0	4
20	R:R:R325	6.22	5	5	4
21	R:R:Q329	5.61	4	0	7
22	R:R:F340	8.39	4	1	9
23	R:R:M341	3.2825	4	0	8
24	R:R:Y344	6.00375	8	1	9
25	R:R:F345	6.305	4	0	8
26	R:R:W353	9.76167	6	8	9
27	R:R:W361	5.935	4	4	9
28	R:R:I374	3.79	6	0	9
29	R:R:W386	5.962	5	8	9
30	R:R:I396	10.3875	4	1	7
31	R:R:D403	6.36	4	0	9
32	R:R:L407	8.175	4	1	8
33	R:R:Y412	5.844	5	1	6
34	R:R:V413	5.8725	4	1	9
35	R:R:R422	6.145	4	0	6
36	R:R:F424	5.914	5	1	8
37	R:R:M468	6.245	4	4	9
38	R:R:I471	5.975	4	4	9
39	R:R:Y478	15.7575	4	2	8
40	R:R:P481	5.135	4	2	9
41	R:R:L486	2.2525	4	0	8
42	R:R:Y489	5.235	6	1	4
43	R:R:Y491	8.675	4	7	9
44	R:R:E492	7.7525	4	1	9
45	R:R:W499	5.4	4	7	9
46	R:R:W503	8.668	5	6	5
47	R:R:F527	9.128	5	1	6
48	R:R:F530	6.925	4	1	7
49	R:R:M531	6.3075	4	0	8
50	R:R:K533	5.538	5	1	9
51	R:R:Y534	5.148	5	0	8
52	R:R:M536	5.6525	4	2	8
53	R:R:W547	9.2675	4	0	9
54	R:R:I548	4.3625	4	3	8
55	R:R:W557	8.62	5	3	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F224	R:R:M243	18.2381	4.98	Yes	Yes	6	6	7
2	R:R:M243	R:R:P233	50.0447	5.03	Yes	Yes	6	7	7
3	R:R:L214	R:R:P233	14.7866	4.93	No	Yes	0	7	7
4	R:R:L214	R:R:Y324	11.2491	4.69	No	No	0	7	2
5	R:R:M243	R:R:Y244	81.0977	11.97	Yes	No	0	7	4
6	R:R:F245	R:R:Y244	100	4.13	Yes	No	0	8	4
7	R:R:F245	R:R:L407	30.031	18.27	Yes	Yes	1	8	8
8	R:R:L407	R:R:Y534	32.691	4.69	Yes	Yes	0	8	8
9	R:R:S408	R:R:Y534	14.1879	7.63	No	Yes	0	8	8
10	R:R:D405	R:R:S408	13.5065	8.83	No	No	0	9	8
11	R:R:D405	R:R:L415	13.2863	8.14	No	No	0	9	7
12	R:R:D403	R:R:L415	42.5086	5.43	Yes	No	0	9	7
13	R:R:D403	R:R:Q329	30.8087	7.83	Yes	Yes	0	9	7
14	R:R:Q329	R:R:Y222	24.8864	10.15	Yes	Yes	0	7	6
15	R:R:F245	R:R:F530	33.3379	7.5	Yes	Yes	1	8	7
16	R:R:E492	R:R:F530	18.6717	12.83	Yes	Yes	1	9	7
17	R:R:E492	R:R:Y489	19.4288	5.61	Yes	Yes	1	9	4
18	R:R:Y412	R:R:Y489	38.5444	4.96	Yes	Yes	1	6	4
19	R:R:L415	R:R:Y412	32.0337	3.52	No	Yes	0	7	6
20	R:R:F530	R:R:K533	16.3214	3.72	Yes	Yes	1	7	9
21	R:R:K533	R:R:Y489	20.2753	5.97	Yes	Yes	1	9	4
22	R:R:G241	R:R:P233	34.7281	4.06	No	Yes	0	8	7
23	R:R:G241	R:R:R238	32.956	4.5	No	No	0	8	4
24	R:R:E235	R:R:R238	31.6105	18.61	No	No	0	4	4
25	R:R:E235	R:R:R325	28.097	3.49	No	Yes	0	4	4
26	R:R:D311	R:R:R325	20.7226	8.34	Yes	Yes	5	6	4
27	R:R:D311	R:R:R250	15.2065	9.53	Yes	Yes	5	6	6
28	R:R:W499	R:R:Y244	20.8018	3.86	Yes	No	0	9	4
29	R:R:F245	R:R:F527	40.9704	8.57	Yes	Yes	1	8	6
30	R:R:F527	R:R:M531	44.5286	14.93	Yes	Yes	0	6	8
31	R:R:M531	R:R:W256	57.1473	3.49	Yes	No	0	8	8
32	R:R:L535	R:R:W256	53.9711	6.83	No	No	2	7	8
33	R:R:V257	R:R:Y534	32.808	5.05	No	Yes	0	7	8
34	R:R:H303	R:R:V257	32.8975	4.15	Yes	No	0	6	7
35	R:R:F297	R:R:T268	37.5946	6.49	Yes	No	0	5	9
36	R:R:F297	R:R:M298	40.6573	3.73	Yes	No	0	5	6
37	R:R:M298	R:R:V342	62.4295	3.04	No	No	0	6	5
38	R:R:A302	R:R:V342	62.5877	1.7	No	No	0	7	5
39	R:R:A302	R:R:V410	64.212	1.7	No	No	0	7	7
40	R:R:H303	R:R:V410	64.5699	4.15	Yes	No	0	6	7
41	R:R:L535	R:R:M536	58.1796	4.24	No	Yes	2	7	8
42	R:R:S293	R:R:T268	37.0578	4.8	No	No	0	8	9
43	R:R:M536	R:R:P481	56.6311	6.71	Yes	Yes	2	8	9
44	R:R:P481	R:R:V540	72.1714	3.53	Yes	No	2	9	8
45	R:R:V540	R:R:Y296	28.6063	6.31	No	Yes	2	8	8
46	R:R:L292	R:R:Y296	27.161	4.69	No	Yes	2	8	8
47	R:R:L292	R:R:T544	54.0158	4.42	No	No	0	8	8
48	R:R:S293	R:R:T544	38.8197	4.8	No	No	0	8	8
49	R:R:V540	R:R:Y478	43.8025	6.31	No	Yes	2	8	8
50	R:R:L292	R:R:Y478	27.7942	8.21	No	Yes	2	8	8
51	R:R:S293	R:R:T271	60.1858	9.59	No	No	0	8	9
52	R:R:I548	R:R:T271	58.8541	6.08	Yes	No	0	8	9
53	R:R:I548	R:R:T274	12.1198	4.56	Yes	Yes	3	8	9
54	R:R:F282	R:R:I548	30.8844	3.77	Yes	Yes	3	9	8
55	R:R:I548	R:R:T553	18.0213	3.04	Yes	No	0	8	9
56	R:R:S550	R:R:T553	16.4074	3.2	No	No	0	9	9
57	R:R:K552	R:R:S550	13.159	3.06	No	No	0	9	9
58	R:R:K552	R:R:R281	11.5244	7.43	No	Yes	0	9	9
59	R:R:E286	R:R:F282	26.2078	11.66	No	Yes	0	9	9
60	R:R:F346	R:R:M298	32.7977	17.42	No	No	0	9	6
61	R:R:F345	R:R:F346	31.8926	9.65	Yes	No	0	8	9
62	R:R:F345	R:R:W386	24.7694	7.02	Yes	Yes	0	8	9
63	R:R:W353	R:R:W386	21.7722	8.43	Yes	Yes	8	9	9
64	R:R:P288	R:R:W353	22.278	5.4	No	Yes	0	8	9
65	R:R:P288	R:R:T360	42.192	3.5	No	No	0	8	8
66	R:R:I374	R:R:T360	40.6882	3.04	Yes	No	0	9	8
67	R:R:I289	R:R:T544	32.9594	6.08	No	No	0	9	8
68	R:R:I289	R:R:L357	31.724	5.71	No	No	0	9	9
69	R:R:L357	R:R:P288	30.7674	6.57	No	No	0	9	8
70	R:R:I374	R:R:Y284	18.2347	3.63	Yes	Yes	0	9	9
71	R:R:F381	R:R:Y284	11.693	7.22	No	Yes	0	8	9
72	R:R:E286	R:R:W547	24.7454	6.54	No	Yes	0	9	9
73	R:R:W354	R:R:Y478	20.7743	38.58	No	Yes	0	9	8
74	R:R:S358	R:R:W354	19.8107	6.18	No	No	0	8	9
75	R:R:L440	R:R:S358	17.8975	7.51	No	No	0	8	8
76	R:R:L440	R:R:S475	17.0406	6.01	No	No	0	8	8
77	R:R:G472	R:R:S475	16.2216	3.71	No	No	0	9	8
78	R:R:F444	R:R:G472	15.5093	4.52	No	No	0	8	9
79	R:R:I471	R:R:W547	15.8775	3.52	Yes	Yes	0	9	9
80	R:R:H303	R:R:L343	34.7454	5.14	Yes	No	0	6	6
81	R:R:L343	R:R:Y412	34.532	8.21	No	Yes	0	6	6
82	R:R:Y344	R:R:Y412	37.2127	4.96	Yes	Yes	1	9	6
83	R:R:T393	R:R:Y344	14.0365	3.75	No	Yes	0	9	9
84	R:R:M341	R:R:T393	12.6635	3.01	Yes	No	0	8	9
85	R:R:M348	R:R:Y344	12.8355	11.97	No	Yes	0	8	9
86	R:R:L429	R:R:M348	10.0688	4.24	No	No	0	8	8
87	R:R:I374	R:R:W369	13.2897	7.05	Yes	No	0	9	9
88	R:R:F444	R:R:W361	10.5781	9.02	No	Yes	4	8	9
89	R:R:L433	R:R:L486	12.8355	1.38	No	Yes	0	8	8
90	R:R:L447	R:R:W361	16.201	2.28	No	Yes	4	8	9
91	R:R:L447	R:R:M468	14.0262	7.07	No	Yes	4	8	9
92	R:R:M468	R:R:R451	11.7894	4.96	Yes	No	4	9	9
93	R:R:E465	R:R:R451	10.671	12.79	No	No	0	8	9
94	R:R:F474	R:R:W547	11.9098	10.02	No	Yes	0	9	9
95	R:R:P481	R:R:V480	16.8445	3.53	Yes	No	0	9	8
96	R:R:T483	R:R:V480	14.3668	3.17	No	No	0	5	8
97	R:R:T479	R:R:T483	13.3689	1.57	No	No	0	8	5
98	R:R:T437	R:R:T479	12.5189	3.14	No	No	0	7	8
99	R:R:L433	R:R:T437	12.2092	2.95	No	No	0	8	7
100	R:R:M243	R:R:W503	12.3159	17.45	Yes	Yes	6	7	5
101	R:R:M531	R:R:Y534	15.437	3.59	Yes	Yes	0	8	8
102	R:R:I471	R:R:W361	11.1081	8.22	Yes	Yes	4	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 8YY8_nogp

PDB Summary
PDB	8YY8_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	315
Number of Links	362
Number of Hubs	55
Number of Links mediated by Hubs	196
Number of Communities	11
Number of Nodes involved in Communities	73
Number of Links involved in Communities	101

Path Summary
Number Of Nodes in MetaPath	103
Number Of Links MetaPath	102
Number of Shortest Paths	73084
Length Of Smallest Path	3
Average Path Length	15.9413
Length of Longest Path	38
Minimum Path Strength	1.38
Average Path Strength	6.14165
Maximum Path Strength	24.255
Minimum Path Correlation	0.7
Average Path Correlation	0.935841
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.33333
Average % Of Corr. Nodes	49.8796
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.5179
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • G protein-coupled receptor activity • PDZ domain binding • protein domain specific binding • signaling receptor binding • G protein-coupled receptor binding • frizzled binding • ion binding • phosphatidylinositol-4,5-bisphosphate binding • anion binding • phosphatidylinositol bisphosphate binding • phospholipid binding • lipid binding • phosphatidylinositol phosphate binding • phosphatidylinositol binding • small molecule binding • Wnt-protein binding • regulation of signaling • cell surface receptor signaling pathway • regulation of Wnt signaling pathway • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • regulation of signal transduction • regulation of response to stimulus • regulation of cell communication • Wnt signaling pathway • wound healing • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • positive regulation of biological process • response to stress • regulation of cell population proliferation • regulation of epithelial cell proliferation • response to wounding • epithelial cell proliferation • positive regulation of cellular process • positive regulation of epithelial cell proliferation involved in wound healing • regulation of developmental process • cellular developmental process • negative regulation of biological process • negative regulation of muscle cell differentiation • regulation of cell differentiation • regulation of striated muscle cell differentiation • regulation of cardiac muscle cell differentiation • muscle cell differentiation • striated muscle tissue development • muscle structure development • cell differentiation • negative regulation of cardiac muscle cell differentiation • negative regulation of cellular process • negative regulation of cell differentiation • regulation of multicellular organismal process • muscle tissue development • negative regulation of cardiocyte differentiation • heart development • cardiac muscle tissue development • negative regulation of developmental process • negative regulation of striated muscle cell differentiation • cardiac muscle cell differentiation • tissue development • cardiocyte differentiation • circulatory system development • regulation of muscle cell differentiation • regulation of cardiocyte differentiation • striated muscle cell differentiation • negative regulation of multicellular organismal process • non-canonical Wnt signaling pathway • cell adhesion • substrate adhesion-dependent cell spreading • cell-substrate adhesion • response to retinoic acid • cellular response to retinoic acid • nervous system development • generation of neurons • neurogenesis • neuron differentiation • hemopoiesis • cell activation • cell development • mononuclear cell differentiation • lymphocyte activation • lymphocyte differentiation • leukocyte activation • T cell differentiation in thymus • T cell activation • immune system process • T cell differentiation • leukocyte differentiation • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of response to stimulus • positive regulation of JNK cascade • regulation of intracellular signal transduction • JNK cascade • positive regulation of MAPK cascade • regulation of JNK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • positive regulation of signaling • Wnt signaling pathway, planar cell polarity pathway • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • maintenance of cell number • stem cell population maintenance • regulation of cell-substrate adhesion • regulation of cell adhesion • negative regulation of cell adhesion • negative regulation of cell-substrate adhesion • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of nucleobase-containing compound metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • positive regulation of phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • positive regulation of phosphate metabolic process • regulation of phosphate metabolic process • phosphate-containing compound metabolic process • regulation of phosphorus metabolic process • regulation of phosphorylation • phosphorus metabolic process • somatic stem cell division • stem cell division • cell division • negative regulation of cell fate specification • embryo development • regulation of ectodermal cell fate specification • negative regulation of cell fate commitment • ectoderm development • ectodermal cell differentiation • negative regulation of ectodermal cell fate specification • formation of primary germ layer • ectodermal cell fate commitment • regulation of cell fate commitment • embryonic morphogenesis • ectodermal cell fate specification • cell fate specification • gastrulation • ectoderm formation • cell fate commitment involved in formation of primary germ layer • anatomical structure morphogenesis • regulation of cell fate specification • anatomical structure formation involved in morphogenesis • cell fate commitment • epithelium development • mesenchymal to epithelial transition • epithelial cell differentiation • tissue regeneration • skeletal muscle tissue regeneration • developmental growth • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • growth • regeneration • endosome membrane • endosome • intracellular vesicle • recycling endosome • cytoplasmic vesicle membrane • recycling endosome membrane • vesicle membrane • cytoplasmic vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O75084
Sequence	>8YY8_nogp_Chain_R C P R Q L K V P P Y L G Y R F L G E R D C G A P C E P G R A N G L M Y F K E E E R R F A R L W V G V W S V L C C A S T L F T V L T Y L V D M R R F S Y P E R P I I F L S G C Y F M V A V A H V A G F L L E D R A V C V E R F S D D G Y R T V A Q G T K K E G C T I L F M V L Y F F G M A S S I W W V I L S L T W F L A A G M K W G H E A I E A N S Q Y F H L A A W A V P A V K T I T I L A M G Q V D G D L L S G V C Y V G L S S V D A L R G F V L A P L F V Y L F I G T S F L L A G F V S L F R I R T I M K H D G T K T E K L E K L M V R I G V F S V L Y T V P A T I V L A C Y F Y E Q A F R E H W E R T W L L Q T C D F T V F M I K Y L M T M I V G I T T G F W I W S G K T L Q S W R R F Y H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9EPO	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	-	1.9	2024-10-02	To be published
	9EW2	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	Gs/β1/γ2	3.2	2024-10-02	To be published
	9EW2 (No Gprot)	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-		3.2	2024-10-02	To be published
	8YY8	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	Gs/β1/γ2	3.22	2024-04-24	10.1038/s41422-021-00525-6
	8YY8 (No Gprot)	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-		3.22	2024-04-24	10.1038/s41422-021-00525-6
	7EVW	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	Gs/β1/γ2	3.22	2021-08-04	10.1038/s41422-021-00525-6
	7EVW (No Gprot)	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-		3.22	2021-08-04	10.1038/s41422-021-00525-6

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