psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C210	R:R:C230	7.28	No	Yes	5	9	9
2	R:R:D322	R:R:R212	9.53	No	No	0	4	3
3	R:R:Q213	R:R:Y324	29.31	No	Yes	0	4	2
4	R:R:L214	R:R:P233	8.21	No	Yes	0	7	7
5	R:R:L214	R:R:Y324	4.69	No	Yes	0	7	2
6	R:R:P217	R:R:V216	3.53	No	Yes	8	5	5
7	R:R:L220	R:R:V216	4.47	Yes	Yes	8	3	5
8	R:R:V216	R:R:Y222	13.88	Yes	Yes	8	5	6
9	R:R:F319	R:R:V216	9.18	Yes	Yes	8	4	5
10	R:R:F319	R:R:P217	15.89	Yes	No	8	4	5
11	R:R:D229	R:R:P218	6.44	No	No	0	5	2
12	R:R:K332	R:R:Y219	4.78	No	No	0	6	3
13	R:R:L220	R:R:Y222	9.38	Yes	Yes	8	3	6
14	R:R:F319	R:R:L220	4.87	Yes	Yes	8	4	3
15	R:R:G221	R:R:R228	4.5	No	No	0	3	2
16	R:R:V316	R:R:Y222	3.79	No	Yes	0	5	6
17	R:R:Q329	R:R:Y222	13.53	Yes	Yes	0	7	6
18	R:R:G226	R:R:R223	7.51	No	No	0	5	4
19	R:R:F224	R:R:L225	15.83	Yes	No	0	6	6
20	R:R:C230	R:R:F224	4.19	Yes	Yes	5	9	6
21	R:R:F224	R:R:G231	4.52	Yes	No	0	6	8
22	R:R:A232	R:R:F224	5.55	No	Yes	0	5	6
23	R:R:F224	R:R:P233	4.33	Yes	Yes	5	6	7
24	R:R:F224	R:R:M243	4.98	Yes	Yes	5	6	7
25	R:R:F224	R:R:W503	5.01	Yes	Yes	5	6	5
26	R:R:E500	R:R:L225	6.63	No	No	0	5	6
27	R:R:L225	R:R:L504	6.92	No	No	0	6	4
28	R:R:C230	R:R:E227	7.6	Yes	No	0	9	5
29	R:R:D229	R:R:R228	11.91	No	No	0	5	2
30	R:R:G241	R:R:P233	4.06	No	Yes	0	8	7
31	R:R:M243	R:R:P233	6.71	Yes	Yes	5	7	7
32	R:R:P233	R:R:W503	5.4	Yes	Yes	5	7	5
33	R:R:C234	R:R:D311	4.67	Yes	Yes	3	9	6
34	R:R:C234	R:R:C315	7.28	Yes	No	3	9	9
35	R:R:C234	R:R:R325	11.14	Yes	Yes	3	9	4
36	R:R:C234	R:R:L406	4.76	Yes	No	0	9	5
37	R:R:E235	R:R:R238	12.79	Yes	No	3	4	4
38	R:R:E235	R:R:R318	5.82	Yes	No	0	4	4
39	R:R:E235	R:R:Y324	5.61	Yes	Yes	3	4	2
40	R:R:L242	R:R:P236	4.93	No	No	3	5	5
41	R:R:P236	R:R:R250	7.21	No	Yes	3	5	6
42	R:R:E247	R:R:G237	4.91	No	No	0	2	3
43	R:R:G241	R:R:R238	4.5	No	No	0	8	4
44	R:R:R238	R:R:Y324	12.35	No	Yes	3	4	2
45	R:R:N240	R:R:T507	11.7	No	No	0	2	4
46	R:R:L242	R:R:R250	8.5	No	Yes	3	5	6
47	R:R:M243	R:R:Y244	11.97	Yes	No	0	7	4
48	R:R:M243	R:R:W503	18.61	Yes	Yes	5	7	5
49	R:R:F245	R:R:Y244	4.13	Yes	No	0	8	4
50	R:R:W499	R:R:Y244	3.86	Yes	No	0	9	4
51	R:R:E249	R:R:F245	5.83	No	Yes	1	6	8
52	R:R:F245	R:R:L407	15.83	Yes	No	1	8	8
53	R:R:F245	R:R:F527	6.43	Yes	Yes	1	8	6
54	R:R:F245	R:R:F530	10.72	Yes	Yes	1	8	7
55	R:R:E249	R:R:K246	5.4	No	No	0	6	4
56	R:R:E247	R:R:R251	11.63	No	No	0	2	3
57	R:R:E249	R:R:F527	10.49	No	Yes	1	6	6
58	R:R:R250	R:R:R254	4.26	Yes	Yes	3	6	6
59	R:R:D311	R:R:R250	7.15	Yes	Yes	3	6	6
60	R:R:L406	R:R:R250	3.64	No	Yes	0	5	6
61	R:R:F252	R:R:W256	6.01	No	Yes	1	6	8
62	R:R:F252	R:R:F527	6.43	No	Yes	1	6	6
63	R:R:F252	R:R:M531	3.73	No	Yes	1	6	8
64	R:R:E310	R:R:R254	11.63	No	Yes	0	7	6
65	R:R:D311	R:R:R254	9.53	Yes	Yes	3	6	6
66	R:R:W256	R:R:W260	16.87	Yes	No	1	8	5
67	R:R:M531	R:R:W256	8.14	Yes	Yes	1	8	8
68	R:R:L535	R:R:W256	9.11	No	Yes	1	7	8
69	R:R:H303	R:R:V257	4.15	Yes	No	0	6	7
70	R:R:V257	R:R:Y534	7.57	No	Yes	0	7	8
71	R:R:F307	R:R:G258	6.02	No	No	0	5	5
72	R:R:L263	R:R:W260	4.56	No	No	0	5	5
73	R:R:L535	R:R:W260	10.25	No	No	1	7	5
74	R:R:H303	R:R:S261	4.18	Yes	No	0	6	8
75	R:R:S261	R:R:V304	4.85	No	No	0	8	5
76	R:R:M538	R:R:S261	4.6	No	No	0	8	8
77	R:R:A300	R:R:C264	3.61	No	No	0	8	9
78	R:R:C264	R:R:M538	6.48	No	No	0	9	8
79	R:R:C265	R:R:F297	6.98	No	Yes	0	5	5
80	R:R:I542	R:R:S267	4.64	No	No	0	8	9
81	R:R:F297	R:R:T268	7.78	Yes	No	0	5	9
82	R:R:L269	R:R:L273	8.3	No	No	0	6	6
83	R:R:F297	R:R:L269	4.87	Yes	No	0	5	6
84	R:R:F270	R:R:T274	7.78	No	Yes	2	7	9
85	R:R:F270	R:R:I548	5.02	No	Yes	2	7	8
86	R:R:F270	R:R:W557	9.02	No	Yes	2	7	9
87	R:R:S293	R:R:T271	9.59	No	No	0	8	9
88	R:R:I548	R:R:T271	6.08	Yes	No	0	8	9
89	R:R:F282	R:R:T274	3.89	Yes	Yes	2	9	9
90	R:R:I548	R:R:T274	4.56	Yes	Yes	2	8	9
91	R:R:T274	R:R:T553	4.71	Yes	No	2	9	9
92	R:R:T274	R:R:W557	10.92	Yes	Yes	2	9	9
93	R:R:M279	R:R:Y275	17.96	No	Yes	0	6	8
94	R:R:R287	R:R:Y275	11.32	No	Yes	0	9	8
95	R:R:I290	R:R:Y275	13.3	No	Yes	0	8	8
96	R:R:V277	R:R:W557	7.36	No	Yes	2	8	9
97	R:R:F560	R:R:V277	15.73	No	No	2	6	8
98	R:R:D278	R:R:R281	13.1	Yes	Yes	2	9	9
99	R:R:D278	R:R:S556	8.83	Yes	No	2	9	8
100	R:R:D278	R:R:R559	8.34	Yes	No	2	9	4
101	R:R:K552	R:R:R281	12.38	No	Yes	0	9	9
102	R:R:R281	R:R:S556	9.22	Yes	No	2	9	8
103	R:R:F282	R:R:I290	5.02	Yes	No	0	9	8
104	R:R:F282	R:R:I548	7.54	Yes	Yes	2	9	8
105	R:R:F282	R:R:T553	7.78	Yes	No	2	9	9
106	R:R:H371	R:R:S283	4.18	No	No	0	7	6
107	R:R:R287	R:R:Y284	14.4	No	Yes	0	9	9
108	R:R:P288	R:R:Y284	5.56	No	Yes	6	8	9
109	R:R:T360	R:R:Y284	3.75	No	Yes	6	8	9
110	R:R:I374	R:R:Y284	4.84	Yes	Yes	6	9	9
111	R:R:E375	R:R:Y284	10.1	No	Yes	0	7	9
112	R:R:S378	R:R:Y284	3.82	No	Yes	0	8	9
113	R:R:F381	R:R:Y284	8.25	Yes	Yes	6	8	9
114	R:R:A364	R:R:P285	5.61	No	No	0	8	9
115	R:R:I374	R:R:P285	5.08	Yes	No	0	9	9
116	R:R:L357	R:R:P288	6.57	No	No	0	9	8
117	R:R:P288	R:R:T360	5.25	No	No	6	8	8
118	R:R:I289	R:R:L357	4.28	No	No	0	9	9
119	R:R:I289	R:R:W547	4.7	No	Yes	0	9	9
120	R:R:F291	R:R:W353	22.05	No	Yes	9	8	9
121	R:R:F291	R:R:H382	10.18	No	No	9	8	9
122	R:R:L292	R:R:Y296	4.69	No	Yes	1	8	8
123	R:R:L292	R:R:Y478	7.03	No	Yes	1	8	8
124	R:R:S293	R:R:T544	7.99	No	No	0	8	8
125	R:R:C295	R:R:F346	4.19	No	No	0	9	9
126	R:R:A349	R:R:C295	3.61	No	No	0	9	9
127	R:R:C295	R:R:S350	5.16	No	No	0	9	8
128	R:R:S350	R:R:Y296	15.26	No	Yes	0	8	8
129	R:R:Y296	R:R:Y478	10.92	Yes	Yes	1	8	8
130	R:R:V540	R:R:Y296	8.83	No	Yes	1	8	8
131	R:R:G541	R:R:Y296	5.79	No	Yes	0	9	8
132	R:R:F297	R:R:M298	3.73	Yes	Yes	11	5	6
133	R:R:F297	R:R:V301	6.55	Yes	No	11	5	4
134	R:R:M298	R:R:V301	4.56	Yes	No	11	6	4
135	R:R:F346	R:R:M298	17.42	No	Yes	0	9	6
136	R:R:H303	R:R:L343	6.43	Yes	No	0	6	6
137	R:R:H303	R:R:V410	5.54	Yes	No	0	6	7
138	R:R:L309	R:R:R312	3.64	No	No	0	6	3
139	R:R:A313	R:R:L309	4.73	No	No	0	6	6
140	R:R:D311	R:R:V314	4.38	Yes	No	0	6	8
141	R:R:C315	R:R:D311	4.67	No	Yes	3	9	6
142	R:R:D311	R:R:R325	7.15	Yes	Yes	3	6	4
143	R:R:G404	R:R:V314	3.68	No	No	0	9	8
144	R:R:G409	R:R:V314	3.68	No	No	0	9	8
145	R:R:C315	R:R:R325	6.96	No	Yes	3	9	4
146	R:R:F319	R:R:V316	3.93	Yes	No	0	4	5
147	R:R:F319	R:R:T326	3.89	Yes	No	0	4	5
148	R:R:D322	R:R:S320	5.89	No	No	0	4	2
149	R:R:L406	R:R:V327	5.96	No	No	0	5	7
150	R:R:D403	R:R:Q329	13.05	No	Yes	0	9	7
151	R:R:T331	R:R:T337	6.28	No	No	0	7	8
152	R:R:L397	R:R:T331	4.42	No	No	0	8	7
153	R:R:C336	R:R:K333	4.85	No	No	0	9	6
154	R:R:C336	R:R:C411	7.28	No	No	0	9	9
155	R:R:M341	R:R:T337	4.52	Yes	No	0	8	8
156	R:R:F340	R:R:M341	3.73	Yes	Yes	4	9	8
157	R:R:F340	R:R:Y344	8.25	Yes	Yes	4	9	9
158	R:R:F340	R:R:I396	11.3	Yes	Yes	4	9	7
159	R:R:F340	R:R:L397	3.65	Yes	No	4	9	8
160	R:R:F340	R:R:V402	15.73	Yes	No	0	9	8
161	R:R:F340	R:R:V413	6.55	Yes	Yes	4	9	9
162	R:R:L397	R:R:M341	4.24	No	Yes	4	8	8
163	R:R:L343	R:R:Y412	9.38	No	Yes	0	6	6
164	R:R:M348	R:R:Y344	13.17	No	Yes	0	8	9
165	R:R:K392	R:R:Y344	5.97	No	Yes	0	6	9
166	R:R:T393	R:R:Y344	3.75	No	Yes	0	9	9
167	R:R:I396	R:R:Y344	8.46	Yes	Yes	4	7	9
168	R:R:Y344	R:R:Y412	6.95	Yes	Yes	4	9	6
169	R:R:V413	R:R:Y344	3.79	Yes	Yes	4	9	9
170	R:R:F424	R:R:Y344	5.16	Yes	Yes	4	8	9
171	R:R:F345	R:R:F346	10.72	Yes	No	0	8	9
172	R:R:F345	R:R:W386	5.01	Yes	Yes	0	8	9
173	R:R:F345	R:R:P389	4.33	Yes	No	0	8	9
174	R:R:F345	R:R:T393	3.89	Yes	No	0	8	9
175	R:R:G347	R:R:S350	3.71	No	No	0	7	8
176	R:R:M348	R:R:P428	5.03	No	No	0	8	9
177	R:R:L429	R:R:M348	4.24	No	No	0	8	8
178	R:R:S351	R:R:Y432	3.82	No	Yes	0	8	6
179	R:R:I352	R:R:V388	4.61	No	No	12	6	5
180	R:R:I352	R:R:Y432	13.3	No	Yes	12	6	6
181	R:R:I356	R:R:W353	10.57	No	Yes	0	6	9
182	R:R:H382	R:R:W353	8.46	No	Yes	9	9	9
183	R:R:A385	R:R:W353	11.67	No	Yes	9	9	9
184	R:R:W353	R:R:W386	11.25	Yes	Yes	9	9	9
185	R:R:S358	R:R:W354	7.41	No	No	0	8	9
186	R:R:W354	R:R:Y478	44.37	No	Yes	0	9	8
187	R:R:V355	R:R:Y432	3.79	No	Yes	0	8	6
188	R:R:I435	R:R:V355	6.14	No	No	0	5	8
189	R:R:F381	R:R:I356	6.28	Yes	No	0	8	6
190	R:R:G436	R:R:S358	3.71	No	No	0	9	8
191	R:R:L440	R:R:S358	7.51	No	No	0	8	8
192	R:R:L359	R:R:L363	4.15	No	No	0	6	9
193	R:R:F439	R:R:L359	12.18	No	No	0	8	6
194	R:R:F381	R:R:T360	3.89	Yes	No	6	8	8
195	R:R:G443	R:R:W361	4.22	No	Yes	0	9	9
196	R:R:F444	R:R:W361	13.03	No	Yes	13	8	9
197	R:R:I471	R:R:W361	9.4	No	Yes	13	9	9
198	R:R:F362	R:R:M367	3.73	No	No	0	8	5
199	R:R:F362	R:R:F439	5.36	No	No	0	8	8
200	R:R:L363	R:R:W369	12.53	No	Yes	6	9	9
201	R:R:I374	R:R:L363	5.71	Yes	No	6	9	9
202	R:R:G366	R:R:S446	3.71	No	No	0	7	8
203	R:R:M367	R:R:W369	5.82	No	Yes	0	5	9
204	R:R:A373	R:R:W369	6.48	No	Yes	0	8	9
205	R:R:I374	R:R:W369	4.7	Yes	Yes	6	9	9
206	R:R:F381	R:R:N377	3.62	Yes	No	0	8	6
207	R:R:Q379	R:R:Y380	5.64	No	No	0	7	8
208	R:R:H382	R:R:W386	8.46	No	Yes	9	9	9
209	R:R:A385	R:R:W386	6.48	No	Yes	9	9	9
210	R:R:P389	R:R:V388	3.53	No	No	0	9	5
211	R:R:V388	R:R:Y432	3.79	No	Yes	12	5	6
212	R:R:F424	R:R:T395	3.89	Yes	No	0	8	5
213	R:R:I396	R:R:V413	12.29	Yes	Yes	4	7	9
214	R:R:F424	R:R:I396	12.56	Yes	Yes	4	8	7
215	R:R:M399	R:R:Q401	5.44	No	No	0	5	7
216	R:R:A420	R:R:Q401	6.06	No	No	0	5	7
217	R:R:D403	R:R:S416	8.83	No	No	0	9	5
218	R:R:D405	R:R:S408	8.83	No	No	0	9	8
219	R:R:D405	R:R:L415	8.14	No	No	0	9	7
220	R:R:F530	R:R:L407	3.65	Yes	No	1	7	8
221	R:R:L407	R:R:Y534	8.21	No	Yes	1	8	8
222	R:R:S408	R:R:Y534	5.09	No	Yes	0	8	8
223	R:R:V413	R:R:Y412	7.57	Yes	Yes	4	9	6
224	R:R:V425	R:R:Y412	10.09	No	Yes	4	8	6
225	R:R:Y412	R:R:Y489	5.96	Yes	Yes	4	6	4
226	R:R:F424	R:R:V413	5.24	Yes	Yes	4	8	9
227	R:R:R422	R:R:V418	7.85	Yes	No	0	6	4
228	R:R:R496	R:R:V418	3.92	No	No	0	7	4
229	R:R:L421	R:R:V425	4.47	No	No	4	9	8
230	R:R:L421	R:R:Y489	4.69	No	Yes	4	9	4
231	R:R:Q493	R:R:R422	12.85	No	Yes	0	6	6
232	R:R:V425	R:R:Y489	8.83	No	Yes	4	8	4
233	R:R:F430	R:R:L486	3.65	No	No	0	3	8
234	R:R:L433	R:R:T479	7.37	No	No	0	8	8
235	R:R:A482	R:R:L433	4.73	No	No	0	8	8
236	R:R:F434	R:R:S438	6.61	No	No	0	3	5
237	R:R:L440	R:R:S475	6.01	No	No	0	8	8
238	R:R:F444	R:R:F448	6.43	No	No	0	8	6
239	R:R:F444	R:R:I471	5.02	No	No	13	8	9
240	R:R:R449	R:R:V445	6.54	No	No	0	8	6
241	R:R:L447	R:R:L464	4.15	No	No	7	8	8
242	R:R:L447	R:R:M468	7.07	No	Yes	7	8	9
243	R:R:F448	R:R:M468	14.93	No	Yes	0	6	9
244	R:R:R451	R:R:T461	3.88	No	No	7	9	8
245	R:R:E465	R:R:R451	12.79	No	No	7	8	9
246	R:R:M468	R:R:R451	3.72	Yes	No	7	9	9
247	R:R:D457	R:R:I453	4.2	No	No	0	6	6
248	R:R:M454	R:R:T459	9.03	No	No	0	8	6
249	R:R:L464	R:R:M454	4.24	No	No	0	8	8
250	R:R:D457	R:R:H456	3.78	No	No	0	6	5
251	R:R:E462	R:R:K460	13.5	No	No	0	6	7
252	R:R:E465	R:R:T461	9.88	No	No	7	8	8
253	R:R:L464	R:R:M468	7.07	No	Yes	7	8	9
254	R:R:I471	R:R:L467	7.14	No	No	0	9	9
255	R:R:R470	R:R:W547	19.99	No	Yes	0	9	9
256	R:R:G472	R:R:S475	3.71	No	No	0	9	8
257	R:R:F474	R:R:W547	12.03	No	Yes	0	9	9
258	R:R:L477	R:R:T543	7.37	No	No	0	8	9
259	R:R:V540	R:R:Y478	5.05	No	Yes	1	8	8
260	R:R:P481	R:R:V480	3.53	Yes	No	0	9	8
261	R:R:M536	R:R:P481	6.71	Yes	Yes	1	8	9
262	R:R:I539	R:R:P481	6.77	No	Yes	1	7	9
263	R:R:P481	R:R:V540	3.53	Yes	No	1	9	8
264	R:R:I484	R:R:M536	10.2	No	Yes	0	4	8
265	R:R:V485	R:R:Y489	3.79	No	Yes	0	8	4
266	R:R:C488	R:R:K533	6.47	No	Yes	0	8	9
267	R:R:K533	R:R:Y489	9.55	Yes	Yes	0	9	4
268	R:R:F490	R:R:Q493	9.37	No	No	0	3	6
269	R:R:F495	R:R:Y491	8.25	No	No	10	4	9
270	R:R:W499	R:R:Y491	10.61	Yes	No	10	9	9
271	R:R:V529	R:R:Y491	11.36	No	No	0	7	9
272	R:R:E492	R:R:R496	5.82	No	No	0	9	7
273	R:R:E492	R:R:F530	8.16	No	Yes	0	9	7
274	R:R:E492	R:R:K533	6.75	No	Yes	0	9	9
275	R:R:A494	R:R:F495	5.55	No	No	0	4	4
276	R:R:F495	R:R:W499	7.02	No	Yes	10	4	9
277	R:R:E497	R:R:R501	11.63	No	No	0	2	2
278	R:R:H498	R:R:T502	6.85	No	No	0	1	4
279	R:R:Q506	R:R:T502	5.67	No	No	0	3	4
280	R:R:T507	R:R:W503	19.41	No	Yes	0	4	5
281	R:R:D526	R:R:T528	8.67	No	No	0	5	6
282	R:R:F527	R:R:M531	16.17	Yes	Yes	1	6	8
283	R:R:F530	R:R:Y534	4.13	Yes	Yes	1	7	8
284	R:R:K533	R:R:Y534	4.78	Yes	Yes	0	9	8
285	R:R:L535	R:R:M536	4.24	No	Yes	1	7	8
286	R:R:I539	R:R:M536	5.83	No	Yes	1	7	8
287	R:R:G545	R:R:I548	3.53	No	Yes	0	8	8
288	R:R:L554	R:R:W549	15.94	No	No	0	5	5
289	R:R:G551	R:R:S550	3.71	No	No	0	6	9
290	R:R:R559	R:R:S556	3.95	No	No	2	4	8
291	R:R:F560	R:R:W557	4.01	No	Yes	2	6	9
292	R:R:W557	R:R:Y561	10.61	Yes	No	2	9	4
293	R:R:H562	R:R:R558	11.28	No	No	0	3	5
294	R:R:F560	R:R:Y561	5.16	No	No	2	6	4
295	R:R:L220	R:R:Y219	3.52	Yes	No	0	3	3
296	R:R:L276	R:R:Y275	3.52	No	Yes	0	6	8
297	R:R:E235	R:R:R325	3.49	Yes	Yes	3	4	4
298	R:R:N377	R:R:Y380	3.49	No	No	0	6	8
299	R:R:L440	R:R:W361	3.42	No	Yes	0	8	9
300	R:R:G414	R:R:L421	3.42	No	No	0	9	9
301	R:R:A420	R:R:S417	3.42	No	No	0	5	7
302	R:R:A302	R:R:V342	3.39	No	No	0	7	5
303	R:R:D403	R:R:G404	3.35	No	No	0	9	9
304	R:R:G323	R:R:Q213	3.29	No	No	0	2	4
305	R:R:C488	R:R:I532	3.27	No	No	0	8	6
306	R:R:A253	R:R:M531	3.22	No	Yes	0	7	8
307	R:R:F282	R:R:R281	3.21	Yes	Yes	2	9	9
308	R:R:A328	R:R:K333	3.21	No	No	0	6	6
309	R:R:T537	R:R:V485	3.17	No	No	0	6	8
310	R:R:H498	R:R:W499	3.17	No	Yes	0	1	9
311	R:R:C508	R:R:L504	3.17	No	No	0	9	4
312	R:R:A387	R:R:L383	3.15	No	No	0	7	5
313	R:R:T437	R:R:T479	3.14	No	No	0	7	8
314	R:R:I435	R:R:V431	3.07	No	No	0	5	5
315	R:R:H371	R:R:P285	3.05	No	No	0	7	9
316	R:R:M298	R:R:V342	3.04	Yes	No	0	6	5
317	R:R:I532	R:R:T528	3.04	No	No	0	6	6
318	R:R:L308	R:R:V304	2.98	No	No	0	4	5
319	R:R:L477	R:R:V473	2.98	No	No	0	8	6
320	R:R:L433	R:R:T483	2.95	No	No	0	8	5
321	R:R:L441	R:R:T437	2.95	No	No	0	6	7
322	R:R:I338	R:R:M341	2.92	No	Yes	0	6	8
323	R:R:I450	R:R:M454	2.92	No	No	0	8	8
324	R:R:I542	R:R:L263	2.85	No	No	0	8	5
325	R:R:H303	R:R:V299	2.77	Yes	No	0	6	8
326	R:R:L309	R:R:L339	2.77	No	No	0	6	8
327	R:R:A442	R:R:F362	2.77	No	No	0	7	8
328	R:R:A420	R:R:F424	2.77	No	Yes	0	5	8
329	R:R:L426	R:R:L486	2.77	No	No	0	7	8
330	R:R:K552	R:R:Q555	2.71	No	No	0	9	4
331	R:R:F474	R:R:T543	2.59	No	No	0	9	9
332	R:R:F546	R:R:I542	2.51	No	No	0	7	8
333	R:R:F307	R:R:L255	2.44	No	No	0	5	4
334	R:R:F490	R:R:L426	2.44	No	No	0	3	7
335	R:R:T479	R:R:W354	2.43	No	No	0	8	9
336	R:R:D278	R:R:R280	2.38	Yes	No	0	9	4
337	R:R:D419	R:R:R422	2.38	No	Yes	0	4	6
338	R:R:F307	R:R:R254	2.14	No	Yes	0	5	6
339	R:R:F430	R:R:F434	2.14	No	No	0	3	3
340	R:R:C411	R:R:G404	1.96	No	No	0	9	9
341	R:R:P217	R:R:P218	1.95	No	No	0	5	2
342	R:R:A305	R:R:G306	1.95	No	No	0	5	9
343	R:R:A365	R:R:G366	1.95	No	No	0	9	7
344	R:R:A365	R:R:G443	1.95	No	No	0	9	9
345	R:R:C210	R:R:P211	1.88	No	No	5	9	6
346	R:R:C230	R:R:P211	1.88	Yes	No	5	9	6
347	R:R:A427	R:R:P428	1.87	No	No	0	6	9
348	R:R:G294	R:R:S293	1.86	No	No	0	5	8
349	R:R:G294	R:R:V272	1.84	No	No	0	5	7
350	R:R:G306	R:R:V410	1.84	No	No	0	9	7
351	R:R:G400	R:R:T331	1.82	No	No	0	7	7
352	R:R:G335	R:R:I338	1.76	No	No	0	4	6
353	R:R:G551	R:R:L554	1.71	No	No	0	6	5
354	R:R:D322	R:R:G323	1.68	No	No	0	4	2
355	R:R:G330	R:R:Q329	1.64	No	Yes	0	7	7
356	R:R:E334	R:R:G335	1.64	No	No	0	6	4
357	R:R:C210	R:R:K215	1.62	No	No	0	9	5
358	R:R:A384	R:R:I352	1.62	No	No	0	6	6
359	R:R:V469	R:R:V473	1.6	No	No	0	7	6
360	R:R:V476	R:R:V480	1.6	No	No	0	7	8
361	R:R:S550	R:R:T553	1.6	No	No	0	9	9
362	R:R:C411	R:R:L339	1.59	No	No	0	9	8
363	R:R:T395	R:R:V391	1.59	No	No	0	5	4
364	R:R:E247	R:R:P236	1.57	No	No	0	2	5
365	R:R:K368	R:R:S446	1.53	No	No	0	9	8
366	R:R:G423	R:R:R422	1.5	No	Yes	0	4	6
367	R:R:K455	R:R:T461	1.5	No	No	0	8	8
368	R:R:L263	R:R:V259	1.49	No	No	0	5	5
369	R:R:D457	R:R:T459	1.45	No	No	0	6	6
370	R:R:G370	R:R:W369	1.41	No	Yes	0	7	9
371	R:R:A390	R:R:F345	1.39	No	Yes	0	8	8
372	R:R:E372	R:R:H371	1.23	No	No	0	9	7
373	R:R:Q329	R:R:R223	1.17	Yes	No	0	7	4
374	R:R:E317	R:R:R325	1.16	No	Yes	0	3	4
375	R:R:E286	R:R:W547	1.09	No	Yes	0	9	9
376	R:R:H562	R:R:Y561	1.09	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V216	7.765	4	8	5
2	R:R:L220	5.56	4	8	3
3	R:R:Y222	10.145	4	8	6
4	R:R:F224	6.34429	7	5	6
5	R:R:C230	5.2375	4	5	9
6	R:R:P233	5.742	5	5	7
7	R:R:C234	6.9625	4	3	9
8	R:R:E235	6.9275	4	3	4
9	R:R:M243	10.5675	4	5	7
10	R:R:F245	8.588	5	1	8
11	R:R:R250	6.152	5	3	6
12	R:R:R254	6.89	4	3	6
13	R:R:W256	10.0325	4	1	8
14	R:R:T274	6.372	5	2	9
15	R:R:Y275	11.525	4	0	8
16	R:R:D278	8.1625	4	2	9
17	R:R:R281	9.4775	4	2	9
18	R:R:F282	5.488	5	2	9
19	R:R:Y284	7.24571	7	6	9
20	R:R:Y296	9.098	5	1	8
21	R:R:F297	5.982	5	11	5
22	R:R:M298	7.1875	4	11	6
23	R:R:H303	4.614	5	0	6
24	R:R:D311	6.25833	6	3	6
25	R:R:F319	7.552	5	8	4
26	R:R:Y324	12.99	4	3	2
27	R:R:R325	5.98	5	3	4
28	R:R:Q329	7.3475	4	0	7
29	R:R:F340	8.20167	6	4	9
30	R:R:M341	3.8525	4	4	8
31	R:R:Y344	6.9375	8	4	9
32	R:R:F345	5.068	5	0	8
33	R:R:W353	12.8	5	9	9
34	R:R:W361	7.5175	4	13	9
35	R:R:W369	6.188	5	6	9
36	R:R:I374	5.0825	4	6	9
37	R:R:F381	5.51	4	6	8
38	R:R:W386	7.8	4	9	9
39	R:R:I396	11.1525	4	4	7
40	R:R:Y412	7.99	5	4	6
41	R:R:V413	7.088	5	4	9
42	R:R:R422	6.145	4	0	6
43	R:R:F424	5.924	5	4	8
44	R:R:Y432	6.175	4	12	6
45	R:R:M468	8.1975	4	7	9
46	R:R:Y478	16.8425	4	1	8
47	R:R:P481	5.135	4	1	9
48	R:R:Y489	6.564	5	4	4
49	R:R:W499	6.165	4	10	9
50	R:R:W503	12.1075	4	5	5
51	R:R:F527	9.88	4	1	6
52	R:R:F530	6.665	4	1	7
53	R:R:M531	7.815	4	1	8
54	R:R:K533	6.8875	4	0	9
55	R:R:Y534	5.956	5	1	8
56	R:R:M536	6.745	4	1	8
57	R:R:W547	9.4525	4	0	9
58	R:R:I548	5.346	5	2	8
59	R:R:W557	8.384	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L214	R:R:P233	44.3196	8.21	No	Yes	0	7	7
2	R:R:L214	R:R:Y324	43.6519	4.69	No	Yes	0	7	2
3	R:R:E235	R:R:Y324	39.6009	5.61	Yes	Yes	3	4	2
4	R:R:E235	R:R:R325	76.0758	3.49	Yes	Yes	3	4	4
5	R:R:D311	R:R:R325	67.4955	7.15	Yes	Yes	3	6	4
6	R:R:D311	R:R:V314	50.5494	4.38	Yes	No	0	6	8
7	R:R:G404	R:R:V314	47.6297	3.68	No	No	0	9	8
8	R:R:D403	R:R:G404	34.3872	3.35	No	No	0	9	9
9	R:R:D403	R:R:Q329	31.4214	13.05	No	Yes	0	9	7
10	R:R:Q329	R:R:Y222	25.5735	13.53	Yes	Yes	0	7	6
11	R:R:V216	R:R:Y222	12.0976	13.88	Yes	Yes	8	5	6
12	R:R:G241	R:R:P233	40.5982	4.06	No	Yes	0	8	7
13	R:R:G241	R:R:R238	39.9305	4.5	No	No	0	8	4
14	R:R:E235	R:R:R238	39.2492	12.79	Yes	No	3	4	4
15	R:R:M243	R:R:Y244	94.9234	11.97	Yes	No	0	7	4
16	R:R:F245	R:R:Y244	100	4.13	Yes	No	0	8	4
17	R:R:F245	R:R:L407	30.8029	15.83	Yes	No	1	8	8
18	R:R:F245	R:R:F527	27.2092	6.43	Yes	Yes	1	8	6
19	R:R:F245	R:R:F530	61.2081	10.72	Yes	Yes	1	8	7
20	R:R:F252	R:R:F527	13.1002	6.43	No	Yes	1	6	6
21	R:R:F252	R:R:W256	12.5863	6.01	No	Yes	1	6	8
22	R:R:F527	R:R:M531	13.7919	16.17	Yes	Yes	1	6	8
23	R:R:M531	R:R:W256	12.7642	8.14	Yes	Yes	1	8	8
24	R:R:L535	R:R:W256	20.2311	9.11	No	Yes	1	7	8
25	R:R:L407	R:R:Y534	30.7066	8.21	No	Yes	1	8	8
26	R:R:F530	R:R:Y534	30.9054	4.13	Yes	Yes	1	7	8
27	R:R:K533	R:R:Y534	55.2074	4.78	Yes	Yes	0	9	8
28	R:R:K533	R:R:Y489	82.494	9.55	Yes	Yes	0	9	4
29	R:R:Y412	R:R:Y489	80.1059	5.96	Yes	Yes	4	6	4
30	R:R:Y344	R:R:Y412	72.1535	6.95	Yes	Yes	4	9	6
31	R:R:T393	R:R:Y344	62.6502	3.75	No	Yes	0	9	9
32	R:R:F345	R:R:T393	62.2713	3.89	Yes	No	0	8	9
33	R:R:F345	R:R:F346	16.336	10.72	Yes	No	0	8	9
34	R:R:E492	R:R:F530	30.8709	8.16	No	Yes	0	9	7
35	R:R:E492	R:R:K533	29.6465	6.75	No	Yes	0	9	9
36	R:R:F345	R:R:W386	54.5858	5.01	Yes	Yes	0	8	9
37	R:R:W353	R:R:W386	52.1401	11.25	Yes	Yes	9	9	9
38	R:R:I356	R:R:W353	51.2108	10.57	No	Yes	0	6	9
39	R:R:F381	R:R:I356	50.6562	6.28	Yes	No	0	8	6
40	R:R:F381	R:R:Y284	40.8106	8.25	Yes	Yes	6	8	9
41	R:R:R287	R:R:Y284	23.3968	14.4	No	Yes	0	9	9
42	R:R:R287	R:R:Y275	22.7573	11.32	No	Yes	0	9	8
43	R:R:I290	R:R:Y275	20.8265	13.3	No	Yes	0	8	8
44	R:R:F282	R:R:I290	20.1714	5.02	Yes	No	0	9	8
45	R:R:I374	R:R:Y284	10.4379	4.84	Yes	Yes	6	9	9
46	R:R:L357	R:R:P288	13.1881	6.57	No	No	0	9	8
47	R:R:I289	R:R:L357	11.8527	4.28	No	No	0	9	9
48	R:R:I289	R:R:W547	10.5111	4.7	No	Yes	0	9	9
49	R:R:L535	R:R:M536	20.656	4.24	No	Yes	1	7	8
50	R:R:M536	R:R:P481	19.554	6.71	Yes	Yes	1	8	9
51	R:R:P481	R:R:V540	18.8905	3.53	Yes	No	1	9	8
52	R:R:V540	R:R:Y478	13.9217	5.05	No	Yes	1	8	8
53	R:R:C295	R:R:F346	10.5906	4.19	No	No	0	9	9
54	R:R:S350	R:R:Y296	10.4065	15.26	No	Yes	0	8	8
55	R:R:C295	R:R:S350	10.0465	5.16	No	No	0	9	8
56	R:R:C411	R:R:G404	12.1635	1.96	No	No	0	9	9
57	R:R:V413	R:R:Y412	10.8355	7.57	Yes	Yes	4	9	6
58	R:R:W354	R:R:Y478	19.329	44.37	No	Yes	0	9	8
59	R:R:S358	R:R:W354	15.6442	7.41	No	No	0	8	9
60	R:R:L440	R:R:S358	14.5726	7.51	No	No	0	8	8
61	R:R:L440	R:R:W361	12.9453	3.42	No	Yes	0	8	9
62	R:R:M243	R:R:P233	83.6986	6.71	Yes	Yes	5	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9EW2_nogp

PDB Summary
PDB	9EW2_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	322
Number of Links	376
Number of Hubs	59
Number of Links mediated by Hubs	215
Number of Communities	13
Number of Nodes involved in Communities	95
Number of Links involved in Communities	133

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	138728
Length Of Smallest Path	3
Average Path Length	20.3888
Length of Longest Path	42
Minimum Path Strength	1.405
Average Path Strength	7.26525
Maximum Path Strength	27.645
Minimum Path Correlation	0.7
Average Path Correlation	0.937524
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	40.6809
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.7789
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • G protein-coupled receptor activity • protein binding • binding • PDZ domain binding • protein domain specific binding • signaling receptor binding • G protein-coupled receptor binding • frizzled binding • ion binding • phosphatidylinositol-4,5-bisphosphate binding • anion binding • phosphatidylinositol bisphosphate binding • phospholipid binding • lipid binding • phosphatidylinositol phosphate binding • phosphatidylinositol binding • small molecule binding • Wnt-protein binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • wound healing • cell population proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • positive regulation of biological process • response to stress • regulation of cell population proliferation • regulation of epithelial cell proliferation • response to wounding • epithelial cell proliferation • positive regulation of cellular process • positive regulation of epithelial cell proliferation involved in wound healing • multicellular organismal process • regulation of developmental process • cellular developmental process • negative regulation of biological process • negative regulation of muscle cell differentiation • regulation of cell differentiation • regulation of striated muscle cell differentiation • regulation of cardiac muscle cell differentiation • muscle cell differentiation • striated muscle tissue development • muscle structure development • multicellular organism development • cell differentiation • negative regulation of cardiac muscle cell differentiation • anatomical structure development • negative regulation of cellular process • negative regulation of cell differentiation • regulation of multicellular organismal process • muscle tissue development • negative regulation of cardiocyte differentiation • system development • developmental process • heart development • cardiac muscle tissue development • negative regulation of developmental process • negative regulation of striated muscle cell differentiation • animal organ development • cardiac muscle cell differentiation • tissue development • cardiocyte differentiation • circulatory system development • regulation of muscle cell differentiation • regulation of cardiocyte differentiation • striated muscle cell differentiation • negative regulation of multicellular organismal process • non-canonical Wnt signaling pathway • cell adhesion • substrate adhesion-dependent cell spreading • cell-substrate adhesion • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • response to retinoic acid • cellular response to chemical stimulus • cellular response to retinoic acid • response to chemical • cellular response to lipid • nervous system development • generation of neurons • neurogenesis • neuron differentiation • hemopoiesis • cell activation • cell development • mononuclear cell differentiation • lymphocyte activation • lymphocyte differentiation • leukocyte activation • T cell differentiation in thymus • T cell activation • immune system process • T cell differentiation • leukocyte differentiation • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of JNK cascade • regulation of intracellular signal transduction • JNK cascade • intracellular signaling cassette • positive regulation of MAPK cascade • regulation of JNK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • positive regulation of signaling • Wnt signaling pathway, planar cell polarity pathway • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • maintenance of cell number • stem cell population maintenance • regulation of cell-substrate adhesion • regulation of cell adhesion • negative regulation of cell adhesion • negative regulation of cell-substrate adhesion • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • positive regulation of phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • positive regulation of phosphate metabolic process • phosphate-containing compound metabolic process • regulation of phosphorus metabolic process • regulation of phosphorylation • phosphorus metabolic process • somatic stem cell division • stem cell division • cell division • negative regulation of cell fate specification • embryo development • regulation of ectodermal cell fate specification • negative regulation of cell fate commitment • ectoderm development • ectodermal cell differentiation • negative regulation of ectodermal cell fate specification • formation of primary germ layer • ectodermal cell fate commitment • regulation of cell fate commitment • embryonic morphogenesis • ectodermal cell fate specification • cell fate specification • gastrulation • ectoderm formation • cell fate commitment involved in formation of primary germ layer • anatomical structure morphogenesis • regulation of cell fate specification • anatomical structure formation involved in morphogenesis • cell fate commitment • epithelium development • mesenchymal to epithelial transition • epithelial cell differentiation • tissue regeneration • skeletal muscle tissue regeneration • developmental growth • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • growth • regeneration • cellular anatomical structure • membrane • cell periphery • plasma membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • endosome membrane • endosome • intracellular vesicle • recycling endosome • endomembrane system
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • cell periphery • plasma membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • endosome membrane • endosome • intracellular vesicle • recycling endosome • endomembrane system • cytoplasmic vesicle membrane • bounding membrane of organelle • recycling endosome membrane • vesicle membrane • cytoplasmic vesicle • cytoplasm • vesicle • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O75084
Sequence	>9EW2_nogp_Chain_R C P R Q L K V P P Y L G Y R F L G E R D C G A P C E P G R A N G L M Y F K E E E R R F A R L W V G V W S V L C C A S T L F T V L T Y L V D M R R F S Y P E R P I I F L S G C Y F M V A V A H V A G F L L E D R A V C V E R F S D D G Y R T V A Q G T K K E G C T I L F M V L Y F F G M A S S I W W V I L S L T W F L A A G M K W G H E A I E A N S Q Y F H L A A W A V P A V K T I T I L A M G Q V D G D L L S G V C Y V G L S S V D A L R G F V L A P L F V Y L F I G T S F L L A G F V S L F R I R T I M K H D G T K T E K L E K L M V R I G V F S V L Y T V P A T I V L A C Y F Y E Q A F R E H W E R T W L L Q T C D F T V F M I K Y L M T M I V G I T T G F W I W S G K T L Q S W R R F Y H Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YY8	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	Gs/β1/γ2	3.22	2024-04-24	doi.org/10.1038/s41422-021-00525-6
	8YY8 (No Gprot)	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-		3.22	2024-04-24	doi.org/10.1038/s41422-021-00525-6
	9EPO	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	-	1.9	2024-10-02	doi.org/10.1038/s41467-024-51664-4
	9EW2	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	Gs/β1/γ2	3.2	2024-10-02	doi.org/10.1038/s41467-024-51664-4
	9EW2 (No Gprot)	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-		3.2	2024-10-02	doi.org/10.1038/s41467-024-51664-4

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