psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F206	R:R:L504	3.65	No	Yes	0	2	4
2	R:R:P207	R:R:P517	3.9	No	No	0	3	1
3	R:R:F208	R:R:F224	4.29	Yes	Yes	1	5	6
4	R:R:F208	R:R:L225	15.83	Yes	No	1	5	6
5	R:R:E227	R:R:F208	4.66	No	Yes	0	5	5
6	R:R:F208	R:R:L504	8.53	Yes	Yes	0	5	4
7	R:R:C210	R:R:P211	3.77	No	Yes	0	9	6
8	R:R:C210	R:R:K215	9.7	No	No	0	9	5
9	R:R:C210	R:R:C230	7.28	No	No	0	9	9
10	R:R:L214	R:R:P211	8.21	No	Yes	1	7	6
11	R:R:P211	R:R:Y511	9.74	Yes	Yes	1	6	4
12	R:R:P211	R:R:V513	5.3	Yes	No	0	6	5
13	R:R:Q213	R:R:Y324	21.42	No	Yes	0	4	2
14	R:R:L214	R:R:Y511	5.86	No	Yes	1	7	4
15	R:R:L220	R:R:V216	4.47	Yes	No	6	3	5
16	R:R:V216	R:R:Y222	6.31	No	No	0	5	6
17	R:R:F319	R:R:V216	7.87	No	No	6	4	5
18	R:R:P217	R:R:Y219	4.17	No	No	0	5	3
19	R:R:F319	R:R:P217	15.89	No	No	0	4	5
20	R:R:D229	R:R:P218	8.05	No	No	0	5	2
21	R:R:L220	R:R:Y219	10.55	Yes	No	0	3	3
22	R:R:F319	R:R:L220	3.65	No	Yes	6	4	3
23	R:R:Q329	R:R:Y222	18.04	No	No	0	7	6
24	R:R:F224	R:R:L225	18.27	Yes	No	1	6	6
25	R:R:C230	R:R:F224	4.19	No	Yes	0	9	6
26	R:R:A232	R:R:F224	4.16	No	Yes	0	5	6
27	R:R:F224	R:R:M243	4.98	Yes	Yes	1	6	7
28	R:R:F224	R:R:W503	4.01	Yes	Yes	1	6	5
29	R:R:E500	R:R:L225	6.63	No	No	0	5	6
30	R:R:G231	R:R:T326	3.64	No	No	0	8	5
31	R:R:G241	R:R:P233	4.06	No	No	0	8	7
32	R:R:C234	R:R:C315	7.28	No	No	0	9	9
33	R:R:E235	R:R:R318	4.65	No	No	0	4	4
34	R:R:E235	R:R:Y324	12.35	No	Yes	0	4	2
35	R:R:E235	R:R:R325	5.82	No	No	0	4	4
36	R:R:E247	R:R:P236	4.72	No	No	7	2	5
37	R:R:P236	R:R:R250	4.32	No	Yes	7	5	6
38	R:R:R238	R:R:Y324	14.4	No	Yes	0	4	2
39	R:R:N240	R:R:Y324	6.98	No	Yes	1	2	2
40	R:R:N240	R:R:S510	7.45	No	No	1	2	1
41	R:R:N240	R:R:Y511	17.44	No	Yes	1	2	4
42	R:R:L242	R:R:R250	8.5	No	Yes	0	5	6
43	R:R:M243	R:R:Y244	13.17	Yes	No	1	7	4
44	R:R:M243	R:R:W503	18.61	Yes	Yes	1	7	5
45	R:R:F245	R:R:Y244	7.22	Yes	No	1	8	4
46	R:R:P525	R:R:Y244	13.91	Yes	No	1	9	4
47	R:R:E249	R:R:F245	4.66	No	Yes	1	6	8
48	R:R:F245	R:R:L407	10.96	Yes	No	1	8	8
49	R:R:F245	R:R:P525	4.33	Yes	Yes	1	8	9
50	R:R:F245	R:R:F527	8.57	Yes	Yes	1	8	6
51	R:R:F245	R:R:F530	9.65	Yes	Yes	1	8	7
52	R:R:E249	R:R:K246	4.05	No	No	0	6	4
53	R:R:E247	R:R:R250	9.3	No	Yes	7	2	6
54	R:R:E247	R:R:R251	18.61	No	No	0	2	3
55	R:R:E249	R:R:F527	13.99	No	Yes	1	6	6
56	R:R:D311	R:R:R250	7.15	No	Yes	0	6	6
57	R:R:F252	R:R:W256	7.02	No	Yes	0	6	8
58	R:R:F252	R:R:F527	4.29	No	Yes	0	6	6
59	R:R:D311	R:R:R254	7.15	No	No	0	6	6
60	R:R:G409	R:R:R254	4.5	No	No	0	9	6
61	R:R:W256	R:R:W260	18.74	Yes	Yes	8	8	5
62	R:R:M531	R:R:W256	6.98	No	Yes	0	8	8
63	R:R:L535	R:R:W256	6.83	No	Yes	8	7	8
64	R:R:H303	R:R:V257	4.15	Yes	No	0	6	7
65	R:R:V257	R:R:Y534	5.05	No	Yes	0	7	8
66	R:R:G258	R:R:S261	3.71	No	No	0	5	8
67	R:R:F307	R:R:G258	6.02	No	No	0	5	5
68	R:R:L535	R:R:W260	10.25	No	Yes	8	7	5
69	R:R:I542	R:R:W260	4.7	No	Yes	0	8	5
70	R:R:H303	R:R:S261	4.18	Yes	No	1	6	8
71	R:R:M538	R:R:S261	6.13	No	No	1	8	8
72	R:R:A300	R:R:C264	3.61	No	No	0	8	9
73	R:R:C264	R:R:M538	4.86	No	No	0	9	8
74	R:R:C264	R:R:I542	4.91	No	No	0	9	8
75	R:R:C265	R:R:F297	4.19	No	Yes	0	5	5
76	R:R:A300	R:R:C265	3.61	No	No	0	8	5
77	R:R:S267	R:R:T544	4.8	No	Yes	0	9	8
78	R:R:G545	R:R:S267	3.71	No	No	0	8	9
79	R:R:F297	R:R:T268	7.78	Yes	No	0	5	9
80	R:R:L269	R:R:L273	8.3	No	No	0	6	6
81	R:R:F297	R:R:L269	6.09	Yes	No	0	5	6
82	R:R:F270	R:R:T274	7.78	No	No	10	7	9
83	R:R:F270	R:R:W557	6.01	No	Yes	10	7	9
84	R:R:S293	R:R:T271	6.4	No	No	9	8	9
85	R:R:T271	R:R:T544	7.85	No	Yes	9	9	8
86	R:R:I548	R:R:T271	7.6	No	No	0	8	9
87	R:R:T274	R:R:T553	7.85	No	No	0	9	9
88	R:R:T274	R:R:W557	7.28	No	Yes	10	9	9
89	R:R:F282	R:R:Y275	11.35	Yes	Yes	4	9	8
90	R:R:E286	R:R:Y275	6.73	No	Yes	0	9	8
91	R:R:I290	R:R:Y275	16.92	No	Yes	4	8	8
92	R:R:I548	R:R:Y275	4.84	No	Yes	0	8	8
93	R:R:V277	R:R:W557	9.81	No	Yes	0	8	9
94	R:R:F560	R:R:V277	9.18	No	No	0	6	8
95	R:R:D278	R:R:R280	14.29	No	No	4	9	4
96	R:R:D278	R:R:F282	5.97	No	Yes	4	9	9
97	R:R:M279	R:R:R559	4.96	No	No	0	6	4
98	R:R:M279	R:R:R563	11.17	No	No	0	6	7
99	R:R:F282	R:R:R280	9.62	Yes	No	4	9	4
100	R:R:E286	R:R:R280	10.47	No	No	0	9	4
101	R:R:F282	R:R:I290	6.28	Yes	No	4	9	8
102	R:R:H371	R:R:S283	5.58	No	No	0	7	6
103	R:R:R287	R:R:Y284	12.35	No	Yes	0	9	9
104	R:R:P288	R:R:Y284	6.95	No	Yes	0	8	9
105	R:R:T360	R:R:Y284	8.74	No	Yes	0	8	9
106	R:R:I374	R:R:Y284	3.63	No	Yes	0	9	9
107	R:R:F381	R:R:Y284	9.28	No	Yes	0	8	9
108	R:R:A364	R:R:P285	3.74	No	No	0	8	9
109	R:R:M468	R:R:P285	5.03	No	No	0	9	9
110	R:R:E286	R:R:L467	6.63	No	No	0	9	9
111	R:R:P288	R:R:W353	4.05	No	Yes	0	8	9
112	R:R:L357	R:R:P288	4.93	No	No	0	9	8
113	R:R:I289	R:R:L357	5.71	No	No	0	9	9
114	R:R:I289	R:R:W547	4.7	No	No	0	9	9
115	R:R:F291	R:R:W353	21.05	No	Yes	5	8	9
116	R:R:F291	R:R:H382	5.66	No	No	5	8	9
117	R:R:L292	R:R:Y296	4.69	No	Yes	0	8	8
118	R:R:S293	R:R:T544	6.4	No	Yes	9	8	8
119	R:R:C295	R:R:F346	4.19	No	No	0	9	9
120	R:R:S350	R:R:Y296	7.63	No	Yes	0	8	8
121	R:R:Y296	R:R:Y478	3.97	Yes	Yes	3	8	8
122	R:R:V540	R:R:Y296	10.09	Yes	Yes	3	8	8
123	R:R:G541	R:R:Y296	5.79	No	Yes	0	9	8
124	R:R:F297	R:R:V301	7.87	Yes	No	0	5	4
125	R:R:F346	R:R:M298	19.9	No	No	0	9	6
126	R:R:L343	R:R:V299	4.47	No	No	0	6	8
127	R:R:H303	R:R:L343	6.43	Yes	No	0	6	6
128	R:R:H303	R:R:S408	5.58	Yes	Yes	1	6	8
129	R:R:H303	R:R:V410	4.15	Yes	No	1	6	7
130	R:R:H303	R:R:M538	7.88	Yes	No	1	6	8
131	R:R:F307	R:R:L308	3.65	No	No	0	5	4
132	R:R:E310	R:R:R312	11.63	No	No	0	7	3
133	R:R:G404	R:R:V314	3.68	No	No	0	9	8
134	R:R:G409	R:R:V314	3.68	No	No	0	9	8
135	R:R:T326	R:R:V316	4.76	No	No	0	5	5
136	R:R:Y324	R:R:Y511	3.97	Yes	Yes	1	2	4
137	R:R:L406	R:R:V327	4.47	No	No	0	5	7
138	R:R:A328	R:R:C336	3.61	No	No	0	6	9
139	R:R:T331	R:R:T337	4.71	No	No	0	7	8
140	R:R:C336	R:R:C411	7.28	No	No	0	9	9
141	R:R:F340	R:R:M341	3.73	Yes	No	2	9	8
142	R:R:F340	R:R:Y344	7.22	Yes	Yes	2	9	9
143	R:R:F340	R:R:I396	7.54	Yes	Yes	2	9	7
144	R:R:F340	R:R:L397	3.65	Yes	No	2	9	8
145	R:R:F340	R:R:V402	15.73	Yes	No	0	9	8
146	R:R:F340	R:R:V413	3.93	Yes	Yes	2	9	9
147	R:R:L397	R:R:M341	5.65	No	No	2	8	8
148	R:R:L343	R:R:Y412	9.38	No	No	0	6	6
149	R:R:M348	R:R:Y344	13.17	No	Yes	2	8	9
150	R:R:K392	R:R:Y344	8.36	Yes	Yes	2	6	9
151	R:R:T393	R:R:Y344	3.75	No	Yes	0	9	9
152	R:R:I396	R:R:Y344	8.46	Yes	Yes	2	7	9
153	R:R:Y344	R:R:Y412	6.95	Yes	No	0	9	6
154	R:R:V413	R:R:Y344	5.05	Yes	Yes	2	9	9
155	R:R:F345	R:R:F346	9.65	Yes	No	0	8	9
156	R:R:F345	R:R:W386	5.01	Yes	Yes	0	8	9
157	R:R:F345	R:R:P389	5.78	Yes	No	0	8	9
158	R:R:F345	R:R:T393	3.89	Yes	No	0	8	9
159	R:R:G347	R:R:S350	3.71	No	No	0	7	8
160	R:R:K392	R:R:M348	4.32	Yes	No	2	6	8
161	R:R:L429	R:R:M348	4.24	No	No	0	8	8
162	R:R:I352	R:R:Y432	13.3	No	No	0	6	6
163	R:R:I356	R:R:W353	8.22	No	Yes	0	6	9
164	R:R:H382	R:R:W353	6.35	No	Yes	5	9	9
165	R:R:A385	R:R:W353	10.37	No	Yes	0	9	9
166	R:R:W353	R:R:W386	12.18	Yes	Yes	5	9	9
167	R:R:S358	R:R:W354	11.12	No	Yes	3	8	9
168	R:R:G436	R:R:W354	5.63	No	Yes	3	9	9
169	R:R:W354	R:R:Y478	39.55	Yes	Yes	3	9	8
170	R:R:F381	R:R:I356	11.3	No	No	0	8	6
171	R:R:L357	R:R:S475	6.01	No	No	0	9	8
172	R:R:G436	R:R:S358	3.71	No	No	3	9	8
173	R:R:L440	R:R:S358	7.51	No	No	0	8	8
174	R:R:L359	R:R:L363	4.15	No	Yes	0	6	9
175	R:R:F439	R:R:L359	10.96	No	No	0	8	6
176	R:R:A365	R:R:W361	5.19	No	No	0	9	9
177	R:R:F444	R:R:W361	4.01	No	No	0	8	9
178	R:R:G472	R:R:W361	7.04	No	No	0	9	9
179	R:R:F362	R:R:L363	3.65	Yes	Yes	0	8	9
180	R:R:F362	R:R:M367	7.46	Yes	No	0	8	5
181	R:R:F362	R:R:F439	5.36	Yes	No	0	8	8
182	R:R:A442	R:R:F362	5.55	No	Yes	0	7	8
183	R:R:L363	R:R:W369	15.94	Yes	No	0	9	9
184	R:R:I374	R:R:L363	4.28	No	Yes	0	9	9
185	R:R:G366	R:R:S446	3.71	No	No	0	7	8
186	R:R:E372	R:R:H371	3.69	No	No	0	9	7
187	R:R:F381	R:R:N377	3.62	No	No	0	8	6
188	R:R:H382	R:R:W386	8.46	No	Yes	5	9	9
189	R:R:K392	R:R:P428	5.02	Yes	No	2	6	9
190	R:R:K392	R:R:Y432	7.17	Yes	No	2	6	6
191	R:R:F424	R:R:T395	5.19	No	No	0	8	5
192	R:R:I396	R:R:V413	9.22	Yes	Yes	2	7	9
193	R:R:F424	R:R:I396	13.82	No	Yes	0	8	7
194	R:R:A420	R:R:Q401	6.06	No	No	0	5	7
195	R:R:D403	R:R:L415	6.79	No	No	0	9	7
196	R:R:D403	R:R:S416	10.31	No	No	0	9	5
197	R:R:D405	R:R:S408	8.83	No	Yes	1	9	8
198	R:R:D405	R:R:Y534	8.05	No	Yes	1	9	8
199	R:R:F530	R:R:L407	3.65	Yes	No	1	7	8
200	R:R:L407	R:R:Y534	8.21	No	Yes	1	8	8
201	R:R:S408	R:R:V410	4.85	Yes	No	1	8	7
202	R:R:S408	R:R:Y534	7.63	Yes	Yes	1	8	8
203	R:R:G414	R:R:V413	3.68	No	Yes	0	9	9
204	R:R:R422	R:R:V418	7.85	No	No	0	6	4
205	R:R:R496	R:R:V418	3.92	Yes	No	0	7	4
206	R:R:L421	R:R:V425	4.47	No	No	0	9	8
207	R:R:L421	R:R:R496	4.86	No	Yes	0	9	7
208	R:R:Q493	R:R:R422	10.51	No	No	0	6	6
209	R:R:V425	R:R:Y489	8.83	No	No	0	8	4
210	R:R:L426	R:R:Q493	3.99	No	No	0	7	6
211	R:R:P428	R:R:Y432	5.56	No	No	2	9	6
212	R:R:F430	R:R:L486	3.65	No	No	0	3	8
213	R:R:F434	R:R:S438	6.61	No	No	0	3	5
214	R:R:F439	R:R:I435	3.77	No	Yes	0	8	5
215	R:R:R449	R:R:V445	3.92	No	No	0	8	6
216	R:R:L464	R:R:M468	4.24	No	No	0	8	9
217	R:R:L464	R:R:V469	4.47	No	No	0	8	7
218	R:R:I471	R:R:L467	7.14	No	No	0	9	9
219	R:R:R470	R:R:W547	13	No	No	0	9	9
220	R:R:G472	R:R:S475	3.71	No	No	0	9	8
221	R:R:F474	R:R:V540	3.93	No	Yes	0	9	8
222	R:R:F474	R:R:W547	10.02	No	No	0	9	9
223	R:R:A482	R:R:Y478	4	No	Yes	0	8	8
224	R:R:V540	R:R:Y478	6.31	Yes	Yes	3	8	8
225	R:R:P481	R:R:V480	5.3	Yes	No	0	9	8
226	R:R:M536	R:R:P481	5.03	No	Yes	0	8	9
227	R:R:I484	R:R:M536	7.29	No	No	0	4	8
228	R:R:V485	R:R:Y489	3.79	No	No	0	8	4
229	R:R:C488	R:R:K533	8.08	No	Yes	0	8	9
230	R:R:K533	R:R:Y489	4.78	Yes	No	0	9	4
231	R:R:F490	R:R:Q493	10.54	No	No	0	3	6
232	R:R:F495	R:R:Y491	5.16	No	No	1	4	9
233	R:R:W499	R:R:Y491	12.54	Yes	No	1	9	9
234	R:R:V529	R:R:Y491	3.79	No	No	0	7	9
235	R:R:E492	R:R:R496	6.98	Yes	Yes	0	9	7
236	R:R:E492	R:R:W499	4.36	Yes	Yes	1	9	9
237	R:R:E492	R:R:F530	8.16	Yes	Yes	1	9	7
238	R:R:E492	R:R:K533	8.1	Yes	Yes	1	9	9
239	R:R:A494	R:R:F495	4.16	No	No	0	4	4
240	R:R:F495	R:R:W499	6.01	No	Yes	1	4	9
241	R:R:E500	R:R:R496	5.82	No	Yes	0	5	7
242	R:R:H498	R:R:M523	6.57	No	No	0	1	3
243	R:R:P525	R:R:W499	22.97	Yes	Yes	1	9	9
244	R:R:F530	R:R:W499	4.01	Yes	Yes	1	7	9
245	R:R:F520	R:R:R501	29.93	No	No	0	1	2
246	R:R:Q506	R:R:T502	4.25	No	No	0	3	4
247	R:R:T507	R:R:W503	21.83	No	Yes	1	4	5
248	R:R:W503	R:R:Y511	3.86	Yes	Yes	1	5	4
249	R:R:L504	R:R:P516	11.49	Yes	No	0	4	4
250	R:R:L505	R:R:P516	4.93	No	No	0	3	4
251	R:R:T507	R:R:Y511	4.99	No	Yes	1	4	4
252	R:R:C508	R:R:C515	7.28	No	No	0	9	9
253	R:R:C515	R:R:K509	6.47	No	No	0	9	3
254	R:R:S510	R:R:Y511	3.82	No	Yes	1	1	4
255	R:R:F530	R:R:P525	5.78	Yes	Yes	1	7	9
256	R:R:D526	R:R:T528	5.78	No	No	0	5	6
257	R:R:D526	R:R:V529	5.84	No	No	0	5	7
258	R:R:F527	R:R:M531	14.93	Yes	No	0	6	8
259	R:R:F530	R:R:K533	3.72	Yes	Yes	1	7	9
260	R:R:G541	R:R:T544	3.64	No	Yes	0	9	8
261	R:R:G551	R:R:S550	3.71	No	No	0	6	9
262	R:R:L554	R:R:R558	4.86	No	No	0	5	5
263	R:R:F560	R:R:R563	6.41	No	No	0	6	7
264	R:R:D419	R:R:R422	3.57	No	No	0	4	6
265	R:R:P525	R:R:S524	3.56	Yes	No	0	9	4
266	R:R:P389	R:R:V388	3.53	No	No	0	9	5
267	R:R:P481	R:R:V540	3.53	Yes	Yes	0	9	8
268	R:R:P514	R:R:V513	3.53	No	No	0	6	5
269	R:R:P285	R:R:T360	3.5	No	No	0	9	8
270	R:R:Q555	R:R:R559	3.5	No	No	0	4	4
271	R:R:E375	R:R:R281	3.49	No	No	0	7	9
272	R:R:L273	R:R:W557	3.42	No	Yes	0	6	9
273	R:R:A420	R:R:S417	3.42	No	No	0	5	7
274	R:R:L554	R:R:W549	3.42	No	No	0	5	5
275	R:R:A232	R:R:V327	3.39	No	No	0	5	7
276	R:R:I539	R:R:P481	3.39	No	Yes	0	7	9
277	R:R:H498	R:R:R501	3.39	No	No	0	1	2
278	R:R:M243	R:R:P233	3.35	Yes	No	0	7	7
279	R:R:G323	R:R:Q213	3.29	No	No	0	2	4
280	R:R:A253	R:R:M531	3.22	No	No	0	7	8
281	R:R:F444	R:R:F448	3.22	No	No	0	8	6
282	R:R:F206	R:R:R501	3.21	No	No	0	2	2
283	R:R:S550	R:R:T553	3.2	No	No	0	9	9
284	R:R:C234	R:R:L406	3.17	No	No	0	9	5
285	R:R:T331	R:R:V402	3.17	No	No	0	7	8
286	R:R:T537	R:R:V485	3.17	No	No	0	6	8
287	R:R:C508	R:R:L504	3.17	No	Yes	0	9	4
288	R:R:A313	R:R:L309	3.15	No	No	0	6	6
289	R:R:I435	R:R:V355	3.07	Yes	No	0	5	8
290	R:R:M367	R:R:S446	3.07	No	No	0	5	8
291	R:R:I435	R:R:V431	3.07	Yes	No	0	5	5
292	R:R:M298	R:R:V342	3.04	No	No	0	6	5
293	R:R:I532	R:R:T528	3.04	No	No	0	6	6
294	R:R:F224	R:R:G231	3.01	Yes	No	0	6	8
295	R:R:F270	R:R:W549	3.01	No	No	0	7	5
296	R:R:F362	R:R:G443	3.01	Yes	No	0	8	9
297	R:R:L429	R:R:S351	3	No	No	0	8	8
298	R:R:L276	R:R:V272	2.98	No	No	0	6	7
299	R:R:L308	R:R:V304	2.98	No	No	0	4	5
300	R:R:L477	R:R:V473	2.98	No	No	0	8	6
301	R:R:L433	R:R:T437	2.95	No	No	0	8	7
302	R:R:L433	R:R:T479	2.95	No	No	0	8	8
303	R:R:L441	R:R:T437	2.95	No	No	0	6	7
304	R:R:D278	R:R:S556	2.94	No	No	0	9	8
305	R:R:Q329	R:R:S416	2.89	No	No	0	7	5
306	R:R:L426	R:R:L486	2.77	No	No	0	7	8
307	R:R:M399	R:R:Q401	2.72	No	No	0	5	7
308	R:R:D405	R:R:L415	2.71	No	No	0	9	7
309	R:R:E465	R:R:M468	2.71	No	No	0	8	9
310	R:R:F444	R:R:V476	2.62	No	No	0	8	7
311	R:R:A349	R:R:W386	2.59	No	Yes	0	9	9
312	R:R:A373	R:R:W369	2.59	No	No	0	8	9
313	R:R:S378	R:R:Y284	2.54	No	Yes	0	8	9
314	R:R:F424	R:R:M399	2.49	No	No	0	8	5
315	R:R:F448	R:R:L447	2.44	No	No	0	6	8
316	R:R:L406	R:R:R250	2.43	No	Yes	0	5	6
317	R:R:T479	R:R:W354	2.43	No	Yes	0	8	9
318	R:R:D322	R:R:R212	2.38	No	No	0	4	3
319	R:R:Q213	R:R:R212	2.34	No	No	0	4	3
320	R:R:N377	R:R:Y380	2.33	No	No	0	6	8
321	R:R:L263	R:R:W260	2.28	No	Yes	0	5	5
322	R:R:G306	R:R:G409	2.11	No	No	0	9	9
323	R:R:G518	R:R:P517	2.03	No	No	0	1	1
324	R:R:C411	R:R:G404	1.96	No	No	0	9	9
325	R:R:P217	R:R:P218	1.95	No	No	0	5	2
326	R:R:A427	R:R:G423	1.95	No	No	0	6	4
327	R:R:P516	R:R:P517	1.95	No	No	0	4	1
328	R:R:P521	R:R:P522	1.95	No	No	0	1	1
329	R:R:A427	R:R:P428	1.87	No	No	0	6	9
330	R:R:G294	R:R:S293	1.86	No	No	0	5	8
331	R:R:G323	R:R:S320	1.86	No	No	0	2	2
332	R:R:G294	R:R:V272	1.84	No	No	0	5	7
333	R:R:G330	R:R:T331	1.82	No	No	0	7	7
334	R:R:P522	R:R:T502	1.75	No	No	0	1	4
335	R:R:G306	R:R:L309	1.71	No	No	0	9	6
336	R:R:A302	R:R:V342	1.7	No	No	0	7	5
337	R:R:M523	R:R:P521	1.68	No	No	0	3	1
338	R:R:E334	R:R:G335	1.64	No	No	0	6	4
339	R:R:S209	R:R:V513	1.62	No	No	0	3	5
340	R:R:C336	R:R:K333	1.62	No	No	0	9	6
341	R:R:A384	R:R:I352	1.62	No	No	0	6	6
342	R:R:V262	R:R:V304	1.6	No	No	0	4	5
343	R:R:V469	R:R:V473	1.6	No	No	0	7	6
344	R:R:T395	R:R:V391	1.59	No	No	0	5	4
345	R:R:A305	R:R:L309	1.58	No	No	0	5	6
346	R:R:A305	R:R:L339	1.58	No	No	0	5	8
347	R:R:A313	R:R:L339	1.58	No	No	0	6	8
348	R:R:A387	R:R:L383	1.58	No	No	0	7	5
349	R:R:T479	R:R:T483	1.57	No	No	0	8	5
350	R:R:I338	R:R:V342	1.54	No	No	0	6	5
351	R:R:K552	R:R:S550	1.53	No	No	0	9	9
352	R:R:I539	R:R:T543	1.52	No	No	0	7	9
353	R:R:L263	R:R:V259	1.49	No	No	0	5	5
354	R:R:E375	R:R:S283	1.44	No	No	0	7	6
355	R:R:E497	R:R:V418	1.43	No	No	0	2	4
356	R:R:K332	R:R:L220	1.41	No	Yes	0	6	3
357	R:R:G370	R:R:W369	1.41	No	No	0	7	9
358	R:R:A390	R:R:F345	1.39	No	Yes	0	8	8
359	R:R:E248	R:R:K246	1.35	No	No	0	3	4
360	R:R:F434	R:R:I435	1.26	No	Yes	0	3	5
361	R:R:F546	R:R:I542	1.26	No	No	0	7	8
362	R:R:F307	R:R:L255	1.22	No	No	0	5	4
363	R:R:D229	R:R:R228	1.19	No	No	0	5	2
364	R:R:Q329	R:R:R223	1.17	No	No	0	7	4
365	R:R:L383	R:R:Y380	1.17	No	No	0	5	8
366	R:R:E317	R:R:R325	1.16	No	No	0	3	4
367	R:R:E375	R:R:Y284	1.12	No	Yes	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F208	8.3275	4	1	5
2	R:R:P211	6.755	4	1	6
3	R:R:L220	5.02	4	6	3
4	R:R:F224	6.13	7	1	6
5	R:R:M243	10.0275	4	1	7
6	R:R:F245	7.565	6	1	8
7	R:R:R250	6.34	5	7	6
8	R:R:W256	9.8925	4	8	8
9	R:R:W260	8.9925	4	8	5
10	R:R:Y275	9.96	4	4	8
11	R:R:F282	8.305	4	4	9
12	R:R:Y284	6.37286	7	0	9
13	R:R:Y296	6.434	5	3	8
14	R:R:F297	6.4825	4	0	5
15	R:R:H303	5.395	6	1	6
16	R:R:Y324	11.824	5	1	2
17	R:R:F340	6.96667	6	2	9
18	R:R:Y344	7.56571	7	2	9
19	R:R:F345	5.144	5	0	8
20	R:R:W353	10.37	6	5	9
21	R:R:W354	14.6825	4	3	9
22	R:R:F362	5.006	5	0	8
23	R:R:L363	7.005	4	0	9
24	R:R:W386	7.06	4	5	9
25	R:R:K392	6.2175	4	2	6
26	R:R:I396	9.76	4	2	7
27	R:R:S408	6.7225	4	1	8
28	R:R:V413	5.47	4	2	9
29	R:R:I435	2.7925	4	0	5
30	R:R:Y478	13.4575	4	3	8
31	R:R:P481	4.3125	4	0	9
32	R:R:E492	6.9	4	1	9
33	R:R:R496	5.395	4	0	7
34	R:R:W499	9.978	5	1	9
35	R:R:W503	12.0775	4	1	5
36	R:R:L504	6.71	4	0	4
37	R:R:Y511	7.09714	7	1	4
38	R:R:P525	10.11	5	1	9
39	R:R:F527	10.445	4	1	6
40	R:R:F530	5.82833	6	1	7
41	R:R:K533	6.17	4	1	9
42	R:R:Y534	7.235	4	1	8
43	R:R:V540	5.965	4	3	8
44	R:R:T544	5.6725	4	9	8
45	R:R:W557	6.63	4	10	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:F206	R:R:L504	11.1354	3.65	No	Yes	0	2	4
2	R:R:F208	R:R:L504	22.039	8.53	Yes	Yes	0	5	4
3	R:R:F208	R:R:F224	23.0294	4.29	Yes	Yes	1	5	6
4	R:R:W503	R:R:Y511	22.7433	3.86	Yes	Yes	1	5	4
5	R:R:Y324	R:R:Y511	13.4241	3.97	Yes	Yes	1	2	4
6	R:R:F224	R:R:M243	54.8839	4.98	Yes	Yes	1	6	7
7	R:R:M243	R:R:Y244	79.7209	13.17	Yes	No	1	7	4
8	R:R:F245	R:R:Y244	78.1019	7.22	Yes	No	1	8	4
9	R:R:F245	R:R:L407	73.3556	10.96	Yes	No	1	8	8
10	R:R:L407	R:R:Y534	100	8.21	No	Yes	1	8	8
11	R:R:D405	R:R:L415	10.3054	2.71	No	No	0	9	7
12	R:R:A232	R:R:F224	29.9842	4.16	No	Yes	0	5	6
13	R:R:L406	R:R:V327	27.8559	4.47	No	No	0	5	7
14	R:R:A232	R:R:V327	28.92	3.39	No	No	0	5	7
15	R:R:L406	R:R:R250	24.4381	2.43	No	Yes	0	5	6
16	R:R:F245	R:R:F527	15.8796	8.57	Yes	Yes	1	8	6
17	R:R:E492	R:R:R496	13.2485	6.98	Yes	Yes	0	9	7
18	R:R:E492	R:R:F530	12.698	8.16	Yes	Yes	1	9	7
19	R:R:D311	R:R:R250	18.5887	7.15	No	Yes	0	6	6
20	R:R:D311	R:R:R254	17.3837	7.15	No	No	0	6	6
21	R:R:G409	R:R:R254	16.17	4.5	No	No	0	9	6
22	R:R:W256	R:R:W260	12.9776	18.74	Yes	Yes	8	8	5
23	R:R:V257	R:R:Y534	48.0419	5.05	No	Yes	0	7	8
24	R:R:H303	R:R:V257	48.1589	4.15	Yes	No	0	6	7
25	R:R:S408	R:R:Y534	48.2694	7.63	Yes	Yes	1	8	8
26	R:R:H303	R:R:S408	54.7106	5.58	Yes	Yes	1	6	8
27	R:R:I542	R:R:W260	13.151	4.7	No	Yes	0	8	5
28	R:R:H303	R:R:M538	25.0125	7.88	Yes	No	1	6	8
29	R:R:A300	R:R:C264	28.9612	3.61	No	No	0	8	9
30	R:R:C264	R:R:M538	24.722	4.86	No	No	0	9	8
31	R:R:C264	R:R:I542	12.9819	4.91	No	No	0	9	8
32	R:R:A300	R:R:C265	27.7324	3.61	No	No	0	8	5
33	R:R:C265	R:R:F297	26.4992	4.19	No	Yes	0	5	5
34	R:R:H303	R:R:L343	99.4604	6.43	Yes	No	0	6	6
35	R:R:L343	R:R:Y412	98.7928	9.38	No	No	0	6	6
36	R:R:Y344	R:R:Y412	98.4526	6.95	Yes	No	0	9	6
37	R:R:T393	R:R:Y344	87.2304	3.75	No	Yes	0	9	9
38	R:R:F345	R:R:T393	86.7645	3.89	Yes	No	0	8	9
39	R:R:F345	R:R:W386	81.8665	5.01	Yes	Yes	0	8	9
40	R:R:W353	R:R:W386	79.3871	12.18	Yes	Yes	5	9	9
41	R:R:P288	R:R:W353	73.5441	4.05	No	Yes	0	8	9
42	R:R:L357	R:R:P288	47.1945	4.93	No	No	0	9	8
43	R:R:I289	R:R:L357	40.3546	5.71	No	No	0	9	9
44	R:R:I289	R:R:W547	39.5505	4.7	No	No	0	9	9
45	R:R:F474	R:R:W547	38.1071	10.02	No	No	0	9	9
46	R:R:F474	R:R:V540	37.3681	3.93	No	Yes	0	9	8
47	R:R:V540	R:R:Y296	21.6337	10.09	Yes	Yes	3	8	8
48	R:R:G541	R:R:Y296	18.6429	5.79	No	Yes	0	9	8
49	R:R:G541	R:R:T544	17.7413	3.64	No	Yes	0	9	8
50	R:R:F297	R:R:L269	22.7737	6.09	Yes	No	0	5	6
51	R:R:L269	R:R:L273	21.5188	8.3	No	No	0	6	6
52	R:R:L273	R:R:W557	20.3615	3.42	No	Yes	0	6	9
53	R:R:T271	R:R:T544	11.2741	7.85	No	Yes	9	9	8
54	R:R:I548	R:R:T271	10.4224	7.6	No	No	0	8	9
55	R:R:P288	R:R:Y284	36.6767	6.95	No	Yes	0	8	9
56	R:R:I374	R:R:Y284	22.4161	3.63	No	Yes	0	9	9
57	R:R:V540	R:R:Y478	10.0106	6.31	Yes	Yes	3	8	8
58	R:R:I374	R:R:L363	21.5318	4.28	No	Yes	0	9	9
59	R:R:F362	R:R:L363	11.35	3.65	Yes	Yes	0	8	9
60	R:R:R496	R:R:V418	10.1992	3.92	Yes	No	0	7	4
61	R:R:F530	R:R:L407	26.0593	3.65	Yes	No	1	7	8
62	R:R:M243	R:R:W503	22.1993	18.61	Yes	Yes	1	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9EPO

PDB Summary
PDB	9EPO
Class	F
SubFamily	Protein
Type	Frizzled
SubType	FZD7
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	1.9
Date	2024-10-02
D.O.I.	doi.org/10.1038/s41467-024-51664-4

Net Summary
I_min	3.61
Number of Linked Nodes	326
Number of Links	367
Number of Hubs	45
Number of Links mediated by Hubs	171
Number of Communities	10
Number of Nodes involved in Communities	71
Number of Links involved in Communities	95

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	82346
Length Of Smallest Path	3
Average Path Length	18.2854
Length of Longest Path	42
Minimum Path Strength	1.28
Average Path Strength	6.64192
Maximum Path Strength	25.335
Minimum Path Correlation	0.7
Average Path Correlation	0.935167
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	3.0303
Average % Of Corr. Nodes	43.7842
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.8641
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • transmembrane signaling receptor activity • signaling receptor activity • Wnt receptor activity • G protein-coupled receptor activity • protein binding • binding • PDZ domain binding • protein domain specific binding • signaling receptor binding • G protein-coupled receptor binding • frizzled binding • ion binding • phosphatidylinositol-4,5-bisphosphate binding • anion binding • phosphatidylinositol bisphosphate binding • phospholipid binding • lipid binding • phosphatidylinositol phosphate binding • phosphatidylinositol binding • small molecule binding • Wnt-protein binding • cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of signaling • regulation of cellular process • cell surface receptor signaling pathway • response to stimulus • regulation of Wnt signaling pathway • signaling • regulation of canonical Wnt signaling pathway • canonical Wnt signaling pathway • biological regulation • regulation of signal transduction • cell communication • regulation of response to stimulus • regulation of cell communication • cellular process • signal transduction • Wnt signaling pathway • wound healing • cell population proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • positive regulation of biological process • response to stress • regulation of cell population proliferation • regulation of epithelial cell proliferation • response to wounding • epithelial cell proliferation • positive regulation of cellular process • positive regulation of epithelial cell proliferation involved in wound healing • multicellular organismal process • regulation of developmental process • cellular developmental process • negative regulation of biological process • negative regulation of muscle cell differentiation • regulation of cell differentiation • regulation of striated muscle cell differentiation • regulation of cardiac muscle cell differentiation • muscle cell differentiation • striated muscle tissue development • muscle structure development • multicellular organism development • cell differentiation • negative regulation of cardiac muscle cell differentiation • anatomical structure development • negative regulation of cellular process • negative regulation of cell differentiation • regulation of multicellular organismal process • muscle tissue development • negative regulation of cardiocyte differentiation • system development • developmental process • heart development • cardiac muscle tissue development • negative regulation of developmental process • negative regulation of striated muscle cell differentiation • animal organ development • cardiac muscle cell differentiation • tissue development • cardiocyte differentiation • circulatory system development • regulation of muscle cell differentiation • regulation of cardiocyte differentiation • striated muscle cell differentiation • negative regulation of multicellular organismal process • non-canonical Wnt signaling pathway • cell adhesion • substrate adhesion-dependent cell spreading • cell-substrate adhesion • response to lipid • response to oxygen-containing compound • cellular response to oxygen-containing compound • response to retinoic acid • cellular response to chemical stimulus • cellular response to retinoic acid • response to chemical • cellular response to lipid • nervous system development • generation of neurons • neurogenesis • neuron differentiation • hemopoiesis • cell activation • cell development • mononuclear cell differentiation • lymphocyte activation • lymphocyte differentiation • leukocyte activation • T cell differentiation in thymus • T cell activation • immune system process • T cell differentiation • leukocyte differentiation • positive regulation of cell communication • positive regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • positive regulation of JNK cascade • regulation of intracellular signal transduction • JNK cascade • intracellular signaling cassette • positive regulation of MAPK cascade • regulation of JNK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • MAPK cascade • positive regulation of signaling • Wnt signaling pathway, planar cell polarity pathway • RNA metabolic process • regulation of primary metabolic process • nucleobase-containing compound metabolic process • RNA biosynthetic process • nucleic acid biosynthetic process • DNA-templated transcription • regulation of RNA metabolic process • regulation of nucleobase-containing compound metabolic process • regulation of RNA biosynthetic process • regulation of biosynthetic process • primary metabolic process • regulation of macromolecule metabolic process • nucleobase-containing compound biosynthetic process • gene expression • macromolecule biosynthetic process • nucleic acid metabolic process • regulation of gene expression • biosynthetic process • metabolic process • regulation of macromolecule biosynthetic process • regulation of DNA-templated transcription • macromolecule metabolic process • regulation of metabolic process • maintenance of cell number • stem cell population maintenance • regulation of cell-substrate adhesion • regulation of cell adhesion • negative regulation of cell adhesion • negative regulation of cell-substrate adhesion • positive regulation of DNA-templated transcription • positive regulation of macromolecule biosynthetic process • positive regulation of metabolic process • positive regulation of biosynthetic process • positive regulation of macromolecule metabolic process • positive regulation of RNA metabolic process • positive regulation of RNA biosynthetic process • positive regulation of phosphorylation • positive regulation of phosphorus metabolic process • phosphorylation • positive regulation of phosphate metabolic process • phosphate-containing compound metabolic process • regulation of phosphorus metabolic process • regulation of phosphorylation • phosphorus metabolic process • somatic stem cell division • stem cell division • cell division • negative regulation of cell fate specification • embryo development • regulation of ectodermal cell fate specification • negative regulation of cell fate commitment • ectoderm development • ectodermal cell differentiation • negative regulation of ectodermal cell fate specification • formation of primary germ layer • ectodermal cell fate commitment • regulation of cell fate commitment • embryonic morphogenesis • ectodermal cell fate specification • cell fate specification • gastrulation • ectoderm formation • cell fate commitment involved in formation of primary germ layer • anatomical structure morphogenesis • regulation of cell fate specification • anatomical structure formation involved in morphogenesis • cell fate commitment • epithelium development • mesenchymal to epithelial transition • epithelial cell differentiation • tissue regeneration • skeletal muscle tissue regeneration • developmental growth • skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration • growth • regeneration • cellular anatomical structure • membrane • cell periphery • plasma membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • endosome membrane • endosome • intracellular vesicle • recycling endosome • endomembrane system
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • cell periphery • plasma membrane • membrane-bounded organelle • intracellular organelle • intracellular anatomical structure • organelle • intracellular membrane-bounded organelle • endosome membrane • endosome • intracellular vesicle • recycling endosome • endomembrane system • cytoplasmic vesicle membrane • bounding membrane of organelle • recycling endosome membrane • vesicle membrane • cytoplasmic vesicle • cytoplasm • vesicle • organelle membrane
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O75084
Sequence	>9EPO_Chain_R F P F S C P R Q L K V P P Y L G Y R F L G E R D C G A P C E P G R A N G L M Y F K E E E R R F A R L W V G V W S V L C C A S T L F T V L T Y L V D M R R F S Y P E R P I I F L S G C Y F M V A V A H V A G F L L E D R A V C V E R F S D D G Y R T V A Q G T K K E G C T I L F M V L Y F F G M A S S I W W V I L S L T W F L A A G M K W G H E A I E A N S Q Y F H L A A W A V P A V K T I T I L A M G Q V D G D L L S G V C Y V G L S S V D A L R G F V L A P L F V Y L F I G T S F L L A G F V S L F R I R L E K L M V R I G V F S V L Y T V P A T I V L A C Y F Y E Q A F R E H W E R T W L L Q T C K S Y A V P C P P G H F P P M S P D F T V F M I K Y L M T M I V G I T T G F W I W S G K T L Q S W R R F Y H R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8YY8	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	Gs/β1/γ2	3.22	2024-04-24	doi.org/10.1038/s41422-021-00525-6
	8YY8 (No Gprot)	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-		3.22	2024-04-24	doi.org/10.1038/s41422-021-00525-6
	9EW2	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-	Gs/β1/γ2	3.2	2024-10-02	doi.org/10.1038/s41467-024-51664-4
	9EW2 (No Gprot)	F	Protein	Frizzled	FZD₇	Homo sapiens	-	-		3.2	2024-10-02	doi.org/10.1038/s41467-024-51664-4

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