Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:H41 4.605426
2A:A:L44 9.3525419
3A:A:L46 3.0725418
4A:A:S51 3.02509
5A:A:I207 5.355419
6A:A:T210 3.994167
7A:A:F219 8.07428
8A:A:M221 4.9654168
9A:A:F222 9.9675417
10A:A:V224 5.9275419
11A:A:Q227 6.045619
12A:A:R228 8.29754229
13A:A:K233 7.905419
14A:A:W234 7.232519
15A:A:F238 8.04333619
16A:A:F246 3.238519
17A:A:D249 8.5125138
18A:A:Y253 8.0756108
19A:A:L270 4.6385156
20A:A:W277 8.43429776
21A:A:W281 12.804515
22A:A:I288 3.686589
23A:A:F290 5.178589
24A:A:K293 9.664139
25A:A:L296 3.255406
26A:A:I308 5.34754107
27A:A:Y311 7.485106
28A:A:F312 4.2408
29A:A:F315 9.29754106
30A:A:Y318 6.9525406
31A:A:D331 8.8654234
32A:A:K338 9.55475
33A:A:Y339 5.51473
34A:A:F340 6.608577107
35A:A:R342 5.61574
36A:A:S349 3.955477
37A:A:Y360 8.326588
38A:A:H362 8.76489
39A:A:F363 8.59575
40A:A:T364 8.0875489
41A:A:F376 6.18333628
42A:A:R385 5.364245
43A:A:H387 4.444528
44A:A:Y391 5.03375824
45B:B:L51 5.8459
46B:B:H54 6.76143759
47B:B:K57 10.46419
48B:B:Y59 6.7418
49B:B:M61 5.032556
50B:B:W63 6.755457
51B:B:V71 4.735498
52B:B:S72 5.2975459
53B:B:D76 6.384559
54B:B:K78 3.62408
55B:B:L79 6.126597
56B:B:I80 8.5725458
57B:B:I81 4.975497
58B:B:W82 9.24833659
59B:B:N88 10.11407
60B:B:K89 4.9759
61B:B:I93 4.648507
62B:B:L95 5.832598
63B:B:W99 10.2675419
64B:B:M101 5.08419
65B:B:Y105 5.4406
66B:B:Y111 6.1125174
67B:B:C114 5.01498
68B:B:L117 4.894519
69B:B:N119 3.7725419
70B:B:I123 3.8665176
71B:B:Y124 4.214506
72B:B:H142 6.2585129
73B:B:Y145 6.75857718
74B:B:F151 4.48833609
75B:B:L152 5.834543
76B:B:Q156 7.1575445
77B:B:T159 4.19409
78B:B:S160 5.5175406
79B:B:D163 9.884129
80B:B:W169 9.8885128
81B:B:F180 7.876547
82B:B:H183 8.74649
83B:B:F199 6.708549
84B:B:V200 5.9775466
85B:B:C204 3.4975417
86B:B:D205 7.228549
87B:B:S207 4.8445
88B:B:K209 10.462546
89B:B:L210 4.15565
90B:B:W211 8.052548
91B:B:R214 9.16449
92B:B:F222 8.8975468
93B:B:I229 6.23467
94B:B:I232 5.7668
95B:B:F234 5.02667665
96B:B:F235 7.384266
97B:B:F241 6.575666
98B:B:T243 5.828568
99B:B:D247 5.5925199
100B:B:T249 6.6954196
101B:B:R251 10.5445198
102B:B:L252 2.58407
103B:B:F253 10.05466
104B:B:E260 8.53406
105B:B:C271 3.408515
106B:B:F278 8.3075407
107B:B:Y289 7.765417
108B:B:D290 7.0375416
109B:B:D291 5.085418
110B:B:W297 7.3925408
111B:B:H311 8.2556119
112B:B:R314 12.704518
113B:B:T321 6.172557
114B:B:W332 10.67619
115B:B:D333 8.55254119
116B:B:L336 4.548557
117B:B:K337 5.1045116
118B:B:W339 7.4385119
119R:R:F17 10.985146
120R:R:Y21 6.414508
121R:R:N32 5.8325409
122R:R:L49 4.424528
123R:R:Y52 6.0475407
124R:R:L53 4.8225428
125R:R:L56 4.128529
126R:R:D60 4.922529
127R:R:Y63 7.928507
128R:R:T66 3.7725407
129R:R:I71 3.67254147
130R:R:Y95 14.2625435
131R:R:M96 5.63525
132R:R:N97 6.86528
133R:R:F98 7.478538
134R:R:Y99 8.016537
135R:R:S100 4.0975427
136R:R:S101 4.975429
137R:R:F104 6.358527
138R:R:L105 4.5775409
139R:R:D111 7.495428
140R:R:R112 3.8775429
141R:R:Y113 7.092528
142R:R:Y118 7.4425426
143R:R:L120 3.305426
144R:R:R126 3.6426
145R:R:F130 3.795403
146R:R:W139 5.325429
147R:R:E142 8.1875428
148R:R:N146 7.0525427
149R:R:F167 4.1675403
150R:R:Y171 8.662533
151R:R:L176 7.5075431
152R:R:W179 12.83433
153R:R:Q180 8.308533
154R:R:I181 2.575403
155R:R:R187 13.494535
156R:R:Y207 6.39405
157R:R:N213 84245
158R:R:T216 5.69254242
159R:R:E220 4.67405
160R:R:F235 4.34409
161R:R:F239 7.44409
162R:R:F242 6.69667637
163R:R:H243 11.1675438
164R:R:M245 3.78435
165R:R:R249 10.825434
166R:R:E253 9.4675434
167R:R:Y272 7.77667634
168R:R:M301 5.7525405
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:M61 10.4423.24NoYes076
2B:B:C317 B:B:S316 10.79185.16NoNo079
3B:B:S316 B:B:W332 10.96694.94NoYes099
4B:B:W332 B:B:Y59 25.96342.89YesYes198
5A:A:C237 B:B:Y59 23.68715.38NoYes188
6A:A:C237 A:A:F238 29.41952.79NoYes189
7A:A:F238 A:A:L44 37.87223.14YesYes199
8A:A:L44 A:A:L46 38.03154.15YesYes198
9A:A:F246 A:A:L46 91.09042.44YesYes198
10A:A:F246 A:A:L289 91.89332.44YesNo099
11A:A:L289 A:A:L291 92.02696.92NoNo098
12A:A:F363 A:A:L291 92.16043.65YesNo058
13A:A:F363 A:A:R342 92.73583.21YesYes754
14A:A:D343 A:A:R342 95.09233.57NoYes034
15A:A:D343 A:A:Y318 95.2235.75NoYes036
16A:A:F340 A:A:Y318 95.748113.41YesYes076
17A:A:F340 A:A:I308 64.56912.51YesYes1077
18A:A:I308 A:A:Y253 65.13686.04YesYes1078
19A:A:K300 A:A:Y253 65.583923.89NoYes1098
20A:A:K300 A:A:L296 65.7672.82NoYes096
21A:A:L296 A:A:S251 65.98657.51YesNo069
22A:A:D249 A:A:S251 33.02865.89YesNo1389
23A:A:D249 A:A:N292 66.92744.04YesNo1389
24A:A:N292 A:A:V247 1004.43NoNo097
25A:A:F290 A:A:V247 96.57783.93YesNo097
26A:A:F290 A:A:I288 48.27712.51YesYes899
27A:A:D378 A:A:I288 47.59545.6NoYes879
28A:A:D378 A:A:Y360 95.141712.64NoYes878
29A:A:I382 A:A:Y360 89.11144.84NoYes868
30A:A:I382 A:A:M386 88.99272.92NoNo063
31A:A:F312 A:A:F340 32.51164.29YesYes087
32A:A:F312 A:A:Y311 33.78064.13YesYes086
33A:A:N264 A:A:Y311 33.790313.96NoYes096
34A:A:N264 A:A:R265 33.81344.82NoNo099
35A:A:D252 A:A:R265 33.860117.87NoNo089
36A:A:D249 A:A:D252 33.85376.65YesNo1388
37A:A:K293 A:A:S251 33.031112.24YesNo1399
38A:A:K293 A:A:N292 33.10328.39YesNo1399
39A:A:F290 A:A:H362 47.76713.39YesYes899
40A:A:D378 A:A:H362 47.68917.56NoYes879
41A:A:M386 A:A:Q390 87.31622.72NoNo034
42A:A:Q390 A:A:Y391 86.00283.38NoYes244
43A:A:I235 A:A:W234 51.9174.7NoYes099
44A:A:W234 B:B:Y145 50.54197.72YesYes198
45B:B:M188 B:B:Y145 23.0384.79NoYes188
46A:A:K233 B:B:M188 22.515710.08YesNo198
47A:A:K233 B:B:D246 22.21188.3YesNo199
48A:A:Y391 R:R:R112 26.86283.09YesYes249
49A:A:Y391 R:R:L49 56.34854.69YesYes248
50B:B:G116 B:B:M101 11.52783.49NoYes099
51B:B:G115 B:B:G116 11.19012.11NoNo099
52B:B:C114 B:B:G115 10.85243.92YesNo089
53B:B:G162 B:B:Y145 25.28767.24NoYes098
54B:B:G162 B:B:S161 25.1183.71NoNo099
55B:B:H142 B:B:S161 24.069913.95YesNo1299
56B:B:H142 B:B:T159 11.96464.11YesYes099
57B:B:T159 B:B:W169 10.92514.85YesYes098
58B:B:I157 B:B:W169 21.14143.52NoYes078
59B:B:A167 B:B:H142 11.43672.93NoYes1249
60B:B:A167 B:B:W169 10.91155.19NoYes1248
61B:B:I157 B:B:I171 10.92564.42NoNo076
62B:B:D246 B:B:S227 22.04615.89NoNo096
63B:B:D247 B:B:S227 21.87494.42YesNo096
64B:B:D247 B:B:R251 20.83144.76YesYes1998
65B:B:E260 B:B:R251 18.393516.28YesYes068
66B:B:E260 B:B:F253 17.877211.66YesYes066
67B:B:F222 B:B:F253 15.960116.08YesYes686
68B:B:F222 B:B:L210 15.49362.44YesYes685
69B:B:L198 B:B:L210 15.24985.54NoYes635
70B:B:L198 B:B:R219 15.1916.07NoNo035
71B:B:D212 B:B:R219 15.01369.53NoNo095
72B:B:D212 B:B:E215 14.658722.09NoNo093
73B:B:F199 B:B:V213 11.95832.62YesNo494
74R:R:I108 R:R:L49 53.83532.85NoYes298
75R:R:I108 R:R:L56 53.84122.85NoYes299
76R:R:D60 R:R:L56 28.12085.43YesYes299
77R:R:D60 R:R:N97 22.41922.69YesYes298
78R:R:L62 R:R:N97 12.32262.75NoYes078
79R:R:L62 R:R:L93 11.93059.69NoNo075
80R:R:L93 R:R:T66 11.58264.42NoYes057
81R:R:S90 R:R:T66 21.97573.2NoYes057
82R:R:S90 R:R:W70 20.56043.71NoNo057
83R:R:W70 R:R:Y73 15.59853.86NoNo2975
84R:R:F167 R:R:Y73 14.89568.25YesNo035
85R:R:L56 R:R:S101 22.36333YesYes299
86R:R:N97 R:R:S101 22.01975.96YesYes289
87R:R:N97 R:R:Y63 31.96313.96YesYes087
88R:R:M94 R:R:Y63 16.68668.38NoYes077
89R:R:M94 R:R:T66 11.8854.52NoYes077
90R:R:R112 R:R:Y290 27.14635.14YesNo099
91R:R:L105 R:R:Y290 26.26193.52YesNo099
92R:R:F235 R:R:L105 25.25132.44YesYes099
93R:R:F235 R:R:F239 23.07447.5YesYes099
94R:R:F239 R:R:F98 15.3217.5YesYes098
95A:A:I235 A:A:L46 52.05082.85NoYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9BHL
Class A
SubFamily Orphan
Type Orphan
SubType GPR65
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1
PDB Resolution 2.8
Date 2025-01-22
D.O.I. doi.org/10.1016/j.cell.2024.11.036
Net Summary
Imin 2.44
Number of Linked Nodes 804
Number of Links 1007
Number of Hubs 168
Number of Links mediated by Hubs 595
Number of Communities 29
Number of Nodes involved in Communities 273
Number of Links involved in Communities 393
Path Summary
Number Of Nodes in MetaPath 96
Number Of Links MetaPath 95
Number of Shortest Paths 2742197
Length Of Smallest Path 3
Average Path Length 40.5931
Length of Longest Path 68
Minimum Path Strength 1.185
Average Path Strength 6.20013
Maximum Path Strength 21.99
Minimum Path Correlation 0.7
Average Path Correlation 0.987252
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 31.5641
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 53.9898
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular process   • signal transduction   • apoptotic process   • cell death   • programmed cell death   • response to pH   • response to abiotic stimulus   • response to acidic pH   • immune response   • immune system process   • positive regulation of organelle organization   • regulation of cytoskeleton organization   • regulation of cellular component organization   • regulation of actin filament-based process   • positive regulation of cellular component organization   • positive regulation of biological process   • regulation of actin filament bundle assembly   • cellular component biogenesis   • cellular component organization   • cellular component assembly   • positive regulation of actin filament bundle assembly   • actin filament bundle organization   • positive regulation of stress fiber assembly   • actin filament-based process   • cellular component organization or biogenesis   • stress fiber assembly   • positive regulation of cellular process   • regulation of actin filament organization   • actin cytoskeleton organization   • actomyosin structure organization   • positive regulation of cellular component biogenesis   • positive regulation of cytoskeleton organization   • actin filament organization   • regulation of cellular component biogenesis   • positive regulation of supramolecular fiber organization   • regulation of organelle organization   • regulation of stress fiber assembly   • organelle organization   • contractile actin filament bundle assembly   • regulation of actomyosin structure organization   • regulation of actin cytoskeleton organization   • actin filament bundle assembly   • regulation of supramolecular fiber organization   • supramolecular fiber organization   • cytoskeleton organization   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • cellular response to monoamine stimulus   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • sensory perception of smell   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to glucagon   • cellular response to glucagon stimulus   • skeletal system development   • bone development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • homeostatic process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • localization   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of hormone levels   • regulation of peptide transport   • regulation of establishment of protein localization   • establishment of protein localization to extracellular region   • export from cell   • regulation of protein transport   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • peptide transport   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • cellular localization   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • endomembrane system   • trans-Golgi network
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9BHL_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGASGKST 
IVKQMRILH TSGIFETKF QVDKVNFHM FDVGGQRDE RRKWIQCFN 
DVTAIIFVV SSYNRLQEA LNLFKSIWN NRWLRTISV ILFLNKQDL 
LAEKVLAGK SKIEDYFPE FARYTTPED ATPEPGEDP RVTRAKYFI 
RDEFLRIST ASGDGRHYC YPHFTCAVD TENRRFNDC RDIIQRMHL 
RQYELLDNS GGDDAI


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9BHL_Chain_B
GRIQMRTRR TLRGHLAKI YAMHWGTDS RLLVSASQD GKLIIWDSY 
TTNKVHAIP LRSSWVMTC AYAPSGNYV ACGGLDNIC SIYNLKTRE 
GNVRVSREL AGHTGYLSC CRFLDDNQI VTSSGDTTC ALWDIETGQ 
QTTTFTGHT GDVMSLSLA PDTRLFVSG ACDASAKLW DVREGMCRQ 
TFTGHESDI NAICFFPNG NAFATGSDD ATCRLFDLR ADQELMTYS 
HDNIICGIT SVSFSKSGR LLLAGYDDF NCNVWDALK ADRAGVLAG 
HDNRVSCLG VTDDGMAVA TGSWDSFLK IWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8IYL9
Sequence
>9BHL_Chain_R
CIEEQHDLD HYLFPIVYI FVIIVSIPA NIGSLCVSF LQAKKESEL 
GIYLFSLSL SDLLYALTL PLWIDYTWN KDNWTFSPA LCKGSAFLM 
YMNFYSSTA FLTCIAVDR YLAVVYPLK FFFLRTRRF ALMVSLSIW 
ILETIFNAV MLWEDETVV EYCDAEKSN FTLCYDKYP LEKWQINLN 
LFRTCTGYA IPLVTILIC NRKVYQAVR HNKATENKE KKRIIKLLV 
SITVTFVLC FTPFHVMLL IRCILEHAV NFEDHSNSG KRTYTMYRI 
TVALTSLNC VADPILYCF VTETGRYDM WNIL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9BHLAOrphanOrphanGPR65Homo sapiens--Gs/β12.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9BHL (No Gprot) AOrphanOrphanGPR65Homo sapiens--2.82025-01-22doi.org/10.1016/j.cell.2024.11.036
9JFTAOrphanOrphanGPR65Homo sapiens--Gs/β1/γ23.272025-08-13doi.org/10.1038/s41422-025-01092-w
9JFT (No Gprot) AOrphanOrphanGPR65Homo sapiens--3.272025-08-13doi.org/10.1038/s41422-025-01092-w




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