Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:I26 2.8725409
2A:A:K34 7.024184
3A:A:H41 6.775466
4A:A:K53 5.1225459
5A:A:I56 3.6975457
6A:A:F219 7.4408
7A:A:F222 10.855427
8A:A:Q227 6.388529
9A:A:K233 6.4975429
10A:A:W234 7.65167629
11A:A:F238 8.332529
12A:A:I244 4.43408
13A:A:I245 5.6375457
14A:A:F246 6.135409
15A:A:V247 3.8275457
16A:A:V248 5.24254137
17A:A:L270 6.2425406
18A:A:F273 6.116509
19A:A:W277 9.412506
20A:A:F290 5.30667659
21A:A:N292 5.54459
22A:A:Q294 7.19254106
23A:A:F312 5.544118
24A:A:Y339 5.1325103
25A:A:F340 10.0465117
26A:A:R342 6.33254104
27A:A:E344 8.3465115
28A:A:F345 7.725138
29A:A:D354 5.64143
30A:A:Y360 9.6925408
31A:A:F363 8.30254105
32A:A:R373 6.42465
33A:A:F376 5.81768
34A:A:K380 4.48467
35A:A:I383 5.28468
36A:A:Y391 7.176154
37B:B:I18 3.49407
38B:B:D27 6.824208
39B:B:I33 4.885403
40B:B:H54 6.75667639
41B:B:K57 10.05429
42B:B:W63 7.87833637
43B:B:L70 6.1725435
44B:B:V71 6.6454228
45B:B:S72 6.135439
46B:B:Q75 6.922529
47B:B:D76 7.915409
48B:B:W82 8.48667639
49B:B:K89 5.215639
50B:B:W99 8.988529
51B:B:Y105 7.475226
52B:B:Y111 8.025404
53B:B:Y124 5.394236
54B:B:L139 7.82409
55B:B:Y145 7.74167628
56B:B:C149 4.25498
57B:B:F151 4.944509
58B:B:L152 4.826503
59B:B:D154 6.7254246
60B:B:I157 5.1075497
61B:B:T159 5.54699
62B:B:W169 8.586598
63B:B:D170 6.924259
64B:B:T173 6.87754255
65B:B:F180 8.65577
66B:B:H183 7.795679
67B:B:L198 7.33754273
68B:B:F199 7.444579
69B:B:D205 5.7975409
70B:B:K209 8.52576
71B:B:W211 8.62857778
72B:B:D212 6.234279
73B:B:F222 9.7125448
74B:B:H225 7.91749
75B:B:E226 10.02543
76B:B:D228 8.945629
77B:B:I232 5.8625448
78B:B:F234 4.085445
79B:B:F235 7.522867126
80B:B:P236 6.0154127
81B:B:N237 6.73254125
82B:B:F241 6.74746
83B:B:T243 7.325448
84B:B:D246 9.48429
85B:B:T249 5.7475446
86B:B:R251 8.424548
87B:B:F253 8.72546
88B:B:D254 4.91409
89B:B:D258 10.555447
90B:B:M262 4.5425404
91B:B:Y264 6.334505
92B:B:F278 5.086676127
93B:B:L285 5.0075406
94B:B:Y289 7.114287
95B:B:H311 9.374589
96B:B:R314 11.2025408
97B:B:T321 6.8925437
98B:B:D323 9.0825437
99B:B:T329 4.535488
100B:B:W332 10.1683629
101B:B:D333 7.062589
102B:B:K337 11.36486
103B:B:W339 7.574589
104G:G:Y40 7.114126
105R:R:W16 6.9625407
106R:R:L21 3.0175403
107R:R:C44 3.34407
108R:R:N51 5.4225409
109R:R:F58 16.2285167
110R:R:W65 11.5285166
111R:R:Y71 5.0625407
112R:R:F73 7.99254166
113R:R:H74 6.13254179
114R:R:Y82 12.016517
115R:R:L89 4.635406
116R:R:Y92 6.3245306
117R:R:Y93 8.57406
118R:R:F111 3.01406
119R:R:F113 7.78416
120R:R:Y114 7.5125415
121R:R:Y118 8.0125417
122R:R:F123 6.2065178
123R:R:H130 9.40754158
124R:R:R131 6.984509
125R:R:L139 5.1565
126R:R:R146 6.7225157
127R:R:W158 7.60754179
128R:R:Q165 5.335417
129R:R:F171 6.06415
130R:R:T182 4.00254304
131R:R:F195 7.2675412
132R:R:M202 5.152516
133R:R:L203 4.095415
134R:R:F207 9.7418
135R:R:F211 5.804516
136R:R:I214 5.7975417
137R:R:Y218 6.79667619
138R:R:F254 7.47519
139R:R:F258 10.35519
140R:R:F261 4.68833607
141R:R:H262 10.2625418
142R:R:R265 10.0325416
143R:R:Y268 6.02333604
144R:R:Y269 8.43415
145R:R:R272 4.8175403
146R:R:L281 3.0175401
147R:R:M286 5.896501
148R:R:Y288 5.475405
149R:R:R292 5.8875406
150R:R:Y306 7.72333619
151R:R:F307 5.015407
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:L70 B:B:W82 18.29064.56YesYes359
2B:B:L70 B:B:M61 21.12854.24YesNo056
3B:B:C317 B:B:M61 21.31696.48NoNo076
4B:B:C317 B:B:S316 21.69343.44NoNo079
5B:B:S316 B:B:W332 21.88154.94NoYes099
6B:B:K57 B:B:W332 49.861422.05YesYes299
7B:B:K57 B:B:Q75 50.00246.78YesYes299
8B:B:Q75 B:B:W99 1005.48YesYes299
9A:A:F238 B:B:W99 68.632915.03YesYes299
10A:A:F238 A:A:L44 44.409513.4YesNo299
11A:A:L44 A:A:L46 44.4018.3NoNo098
12A:A:I244 A:A:L46 44.36094.28YesNo088
13A:A:I244 A:A:V287 44.07834.61YesNo086
14A:A:V287 A:A:W277 45.10564.9NoYes066
15A:A:H357 A:A:W277 44.698826.45NoYes076
16A:A:D354 A:A:H357 44.35333.78YesNo1437
17A:A:D354 A:A:G355 44.17336.71YesNo032
18A:A:G355 A:A:Y358 44.10524.35NoNo024
19A:A:Y358 A:A:Y360 10.75654.96NoYes048
20A:A:D378 A:A:Y360 10.556517.24NoYes078
21B:B:W332 B:B:Y59 49.86143.86YesNo298
22B:B:Q75 B:B:Y59 49.917411.27YesNo298
23A:A:Q385 A:A:Y358 33.77769.02NoNo054
24A:A:L384 A:A:Q385 33.86493.99NoNo065
25A:A:L384 A:A:L388 33.78234.15NoNo068
26A:A:L388 R:R:S243 33.70024.5NoNo087
27A:A:L393 R:R:S243 33.37196.01NoNo087
28A:A:L393 R:R:R131 33.29038.5NoYes089
29A:A:F273 A:A:V287 16.94036.55YesNo096
30A:A:F273 A:A:F345 13.67537.5YesYes098
31A:A:F345 A:A:L270 30.23947.31YesYes086
32A:A:E344 A:A:L270 41.55326.63YesYes056
33A:A:E344 A:A:I341 20.37135.47YesNo1158
34A:A:I341 A:A:S250 19.69347.74NoNo086
35A:A:Q294 A:A:S250 19.01575.78YesNo066
36A:A:F238 A:A:W234 37.52475.01YesYes299
37A:A:R231 A:A:W234 42.15778NoYes099
38A:A:D272 A:A:R231 42.065510.72NoNo089
39A:A:D272 A:A:F246 41.88297.17NoYes089
40A:A:F246 A:A:F273 24.08888.57YesYes099
41B:B:L117 B:B:W99 31.27545.69NoYes299
42A:A:W234 B:B:L117 30.91445.69YesNo299
43A:A:F273 A:A:I348 13.79133.77YesNo094
44A:A:I348 A:A:L270 13.36865.71NoYes046
45A:A:W234 B:B:Y145 45.74655.79YesYes298
46A:A:E344 A:A:F340 18.455515.16YesYes1157
47A:A:T335 A:A:Y339 16.40482.5NoYes043
48A:A:P332 A:A:T335 13.67093.5NoNo014
49B:B:S147 B:B:Y145 34.85146.36NoYes098
50B:B:S147 B:B:S160 34.67534.89NoNo096
51B:B:S160 B:B:V187 34.49918.08NoNo069
52B:B:H183 B:B:V187 23.56558.3YesNo099
53B:B:H183 B:B:K209 11.524110.48YesYes796
54B:B:K209 B:B:T221 10.97069.01YesNo067
55B:B:T221 G:G:E22 10.78428.47NoNo079
56G:G:E22 G:G:L19 10.77253.98NoNo099
57B:B:I18 G:G:L19 10.39312.85YesNo079
58B:B:N313 B:B:W332 81.48215.65NoYes079
59B:B:D333 B:B:N313 81.32854.04YesNo097
60B:B:D333 B:B:H311 80.537310.08YesYes899
61B:B:H311 B:B:T329 40.29174.11YesYes898
62B:B:T329 B:B:W339 39.47474.85YesYes889
63B:B:L308 B:B:W339 78.228814.81NoYes079
64B:B:L308 B:B:V296 74.10534.47NoNo075
65B:B:A305 B:B:V296 73.07223.39NoNo045
66B:B:A305 B:B:I43 72.3833.25NoNo043
67B:B:I43 B:B:V40 72.03823.07NoNo033
68B:B:D298 B:B:V40 70.98355.84NoNo2193
69B:B:D298 B:B:K301 70.65829.68NoNo095
70B:B:I37 B:B:K301 69.96757.27NoNo025
71B:B:I37 B:B:T34 34.81114.56NoNo025
72B:B:I33 B:B:T34 34.46074.56YesNo035
73B:B:I33 B:B:L30 67.50964.28YesNo035
74B:B:L261 B:B:L30 17.78674.15NoNo055
75B:B:D254 B:B:L261 17.07584.07YesNo095
76B:B:H311 B:B:K337 39.938411.79YesYes896
77B:B:K337 B:B:W339 39.43028.12YesYes869
78B:B:I37 G:G:M38 34.81114.37NoNo024
79B:B:I33 G:G:M38 34.46075.83YesNo034
80B:B:L30 B:B:M262 49.05659.9NoYes054
81B:B:C166 B:B:V187 10.76385.12NoNo089
82B:B:C166 B:B:F180 10.58384.19NoYes087
83B:B:F180 B:B:F199 10.029110.72YesYes779
84B:B:F199 B:B:L190 10.19593.65YesNo795
85B:B:H183 B:B:W211 10.77568.46YesYes798
86B:B:F199 B:B:W211 10.35810.02YesYes798
87B:B:M262 B:B:Y264 45.51653.59YesYes045
88B:B:L252 B:B:Y264 15.66397.03NoYes075
89B:B:F278 B:B:L252 14.95313.65YesNo077
90B:B:L285 B:B:Y264 17.80093.52YesYes065
91B:B:F278 B:B:L285 14.95747.31YesYes076
92B:B:F235 B:B:F278 14.25219.65YesYes1267
93B:B:F278 B:B:P236 11.39164.33YesYes1277
94G:G:H44 G:G:Y40 17.799113.07NoYes066
95R:R:R131 R:R:Y218 27.70115.14YesYes099
96R:R:I214 R:R:Y218 24.04783.63YesYes179
97R:R:F254 R:R:I214 23.98357.54YesYes197
98R:R:F254 R:R:F258 20.86528.57YesYes199
99R:R:F258 R:R:L117 20.37079.74YesNo097
100R:R:F261 R:R:L117 20.27893.65YesNo077
101R:R:F261 R:R:Y288 12.66014.13YesYes075
102R:R:F113 R:R:Y82 10.458212.38YesYes167
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 9K25
Class A
SubFamily Nucleotide
Type P2Y
SubType P2Y2
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs-CtGq)/Beta1/Gamma2
PDB Resolution 3.31
Date 2025-06-11
D.O.I. doi.org/10.1038/s41421-025-00797-x
Net Summary
Imin 3.52
Number of Linked Nodes 801
Number of Links 936
Number of Hubs 151
Number of Links mediated by Hubs 548
Number of Communities 30
Number of Nodes involved in Communities 208
Number of Links involved in Communities 280
Path Summary
Number Of Nodes in MetaPath 103
Number Of Links MetaPath 102
Number of Shortest Paths 2650521
Length Of Smallest Path 3
Average Path Length 34.6809
Length of Longest Path 64
Minimum Path Strength 1.235
Average Path Strength 7.03078
Maximum Path Strength 23.375
Minimum Path Correlation 0.7
Average Path Correlation 0.989875
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.77778
Average % Of Corr. Nodes 46.4254
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.0057
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development
Gene OntologyBiological Process• multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • organelle membrane   • intracellular anatomical structure   • cytoplasm   • cytosol   • vacuolar membrane   • lytic vacuole   • vacuole   • intracellular membrane-bounded organelle   • intracellular organelle   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • protein binding   • binding   • G-protein beta-subunit binding   • fibroblast proliferation   • cell population proliferation   • cellular process   • cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • molecular transducer activity   • signaling receptor activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • G protein-coupled pyrimidinergic nucleotide receptor activity   • nucleotide receptor activity   • G protein-coupled UTP receptor activity   • A1 adenosine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • adenosine receptor binding   • G protein-coupled purinergic nucleotide receptor activity   • purinergic nucleotide receptor activity   • phospholipase C-activating G protein-coupled receptor signaling pathway   • regulation of localization   • regulation of body fluid levels   • multicellular organismal process   • secretion by tissue   • regulation of transport   • transport   • secretion   • regulation of mucus secretion   • positive regulation of biological process   • establishment of localization   • mucus secretion   • regulation of secretion   • localization   • body fluid secretion   • positive regulation of secretion   • positive regulation of transport   • positive regulation of mucus secretion   • positive regulation of multicellular organismal process   • regulation of multicellular organismal process   • regulation of biological quality   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • monoatomic ion homeostasis   • intracellular chemical homeostasis   • intracellular monoatomic ion homeostasis   • cellular response to ATP   • response to organophosphorus   • response to ATP   • response to purine-containing compound   • regulation of tube diameter   • system process   • regulation of tube size   • circulatory system process   • vascular process in circulatory system   • blood vessel diameter maintenance   • blood circulation   • regulation of anatomical structure size   • purinergic nucleotide receptor signaling pathway   • cell surface receptor signaling pathway   • G protein-coupled purinergic nucleotide receptor signaling pathway   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • cation binding   • metal ion binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>9K25_Chain_A
EKAEKIEKQ LQKDKQVYR ATHRLLLLG ASGKSTIVK QMRIIFETK 
FQVDKVNFH MFDVGGQRD ERRKWIQCF NDVTAIIFV VSSYNRLQE 
ALNFKSIWN NRWLRTISV ILFLNKQDL LAEKVLAYF PEFARYTTP 
PRVTRAKYF IRDEFLRIS TASGDGRHY CYPHFTCAV DTENRRFND 
CDIIMLRYL LSADAVRSM DNDDDAIKL QNENV


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>9K25_Chain_B
LKNQIRDAR KACADATLS QITNNIDPV GRIQMRTRR TLRGHLAKI 
YAMHWGTDS RLLVSASQD GKLIIWDSY TTNKVHAIP LRSSWVMTC 
AYAPSGNYV ACGGLDNIC SIYNLKTVR VSRELAGHT GYLSCCRFL 
DDNQIVTSS GDTTCALWD IETGQQTTT FTGHTGDVM SLSLAPDTR 
LFVSGACDA SAKLWDVRE GMCRQTFTG HESDINAIC FFPNGNAFA 
TGSDDATCR LFDLRADQE LMTYSHDNI ICGITSVSF SKSGRLLLA 
GYDDFNCNV WDALKADRA GVLAGHDNR VSCLGVTDD GMAVATGSW 
DSFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>9K25_Chain_G
KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP L


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtP41231
Sequence
>9K25_Chain_R
TWDGDELGY RCRFNEDFK YVLLPVSYG VVCVGLCLN AVALYIFLC 
RLKTWNAST TYMFHLAVS DALYAASLP LLVYYYARG DHWPFSTVL 
CKLVRFLFY TNLYCSILF LTCISVHRC LGVLRPLRS LRWGRARYA 
RRVAGAVWV LVLACQAPV LYFVTTSAT CHDTSAPEL FSRFVAYSS 
VMLGLLFAV PFAVILVCY VLMARRLLK AKRKSVRTI AVVLAVFAL 
CFLPFHVTR TLYYSFRSL DLSCHTLNA INMAYKVTR PLASANSCL 
PVLYFLLN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9K20ANucleotideP2YP2Y2Homo sapiensATP-chim(NtGi1-Go)/β1/γ22.652025-06-11doi.org/10.1038/s41421-025-00797-x
9K20 (No Gprot) ANucleotideP2YP2Y2Homo sapiensATP-2.652025-06-11doi.org/10.1038/s41421-025-00797-x
9K0XANucleotideP2YP2Y2Homo sapiensATP-chim(NtGi1-Gs-CtGq)/β1/γ22.832025-06-11doi.org/10.1038/s41421-025-00797-x
9K0X (No Gprot) ANucleotideP2YP2Y2Homo sapiensATP-2.832025-06-11doi.org/10.1038/s41421-025-00797-x
9K25 (No Gprot) ANucleotideP2YP2Y2Homo sapiens--3.312025-06-11doi.org/10.1038/s41421-025-00797-x




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Download 9K25.zip



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