psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y23	37.5	Yes	No	0	0	6
2	L:L:?1	R:R:F27	25.53	Yes	Yes	1	0	2
3	L:L:?1	R:R:E29	7.31	Yes	Yes	1	0	2
4	L:L:?1	R:R:Y93	7.11	Yes	Yes	1	0	6
5	L:L:?1	R:R:D185	8.23	Yes	No	0	0	4
6	L:L:?1	R:R:T186	10.57	Yes	Yes	1	0	3
7	L:L:?1	R:R:Y268	5.17	Yes	Yes	1	0	4
8	L:L:?1	R:R:R272	16.75	Yes	Yes	1	0	3
9	L:L:?1	R:R:K289	10.89	Yes	Yes	1	0	5
10	L:L:?1	R:R:R292	8.71	Yes	Yes	1	0	6
11	R:R:L21	R:R:Y23	4.69	No	No	0	3	6
12	R:R:L21	R:R:R177	7.29	No	No	0	3	3
13	R:R:C25	R:R:R24	6.96	No	No	0	9	2
14	R:R:C25	R:R:C278	7.28	No	No	0	9	7
15	R:R:E29	R:R:F27	8.16	Yes	Yes	1	2	2
16	R:R:F27	R:R:L281	6.09	Yes	No	1	2	1
17	R:R:F27	R:R:N285	7.25	Yes	No	1	2	3
18	R:R:N28	R:R:N282	8.17	No	No	0	5	3
19	R:R:E29	R:R:K32	13.5	Yes	Yes	1	2	3
20	R:R:E29	R:R:N285	11.83	Yes	No	1	2	3
21	R:R:F31	R:R:M286	16.17	No	No	0	5	1
22	R:R:F31	R:R:K289	4.96	No	Yes	0	5	5
23	R:R:K32	R:R:Y33	8.36	Yes	No	0	3	5
24	R:R:K32	R:R:L36	5.64	Yes	No	1	3	5
25	R:R:K32	R:R:Y93	4.78	Yes	Yes	1	3	6
26	R:R:D97	R:R:K32	8.3	Yes	Yes	1	4	3
27	R:R:K289	R:R:K32	10.06	Yes	Yes	1	5	3
28	R:R:L35	R:R:P293	4.93	No	No	0	6	5
29	R:R:L36	R:R:Y93	7.03	No	Yes	1	5	6
30	R:R:P293	R:R:S39	7.13	No	No	0	5	5
31	R:R:L89	R:R:Y40	4.69	No	Yes	0	6	8
32	R:R:R292	R:R:Y40	4.12	Yes	Yes	0	6	8
33	R:R:S296	R:R:Y40	5.09	No	Yes	0	7	8
34	R:R:S296	R:R:V43	6.46	No	No	0	7	7
35	R:R:C300	R:R:V43	5.12	No	No	0	8	7
36	R:R:C44	R:R:L86	6.35	Yes	No	0	7	8
37	R:R:L50	R:R:P303	6.57	No	No	0	8	9
38	R:R:D79	R:R:N51	8.08	Yes	No	0	9	9
39	R:R:A80	R:R:N51	4.69	No	No	0	7	9
40	R:R:N51	R:R:P303	4.89	No	No	0	9	9
41	R:R:C60	R:R:Y56	6.72	No	No	0	5	4
42	R:R:F58	R:R:M72	4.98	No	No	0	7	8
43	R:R:T69	R:R:W65	10.92	No	Yes	0	7	6
44	R:R:T70	R:R:W65	4.85	No	Yes	0	7	6
45	R:R:F73	R:R:W65	14.03	No	Yes	0	6	6
46	R:R:N66	R:R:S68	4.47	No	No	0	7	8
47	R:R:N66	R:R:T69	7.31	No	No	0	7	7
48	R:R:A67	R:R:H130	4.39	No	No	0	7	8
49	R:R:A150	R:R:T70	5.03	No	No	0	8	7
50	R:R:C126	R:R:Y71	8.06	No	Yes	0	6	7
51	R:R:I127	R:R:Y71	4.84	No	Yes	0	9	7
52	R:R:A150	R:R:Y71	4	No	Yes	0	8	7
53	R:R:V153	R:R:Y71	8.83	No	Yes	0	5	7
54	R:R:M72	R:R:Y306	7.18	No	Yes	0	8	9
55	R:R:F123	R:R:H74	10.18	Yes	No	2	8	9
56	R:R:A154	R:R:H74	7.32	No	No	0	7	9
57	R:R:H74	R:R:W158	7.41	No	Yes	2	9	9
58	R:R:F123	R:R:L75	6.09	Yes	No	2	8	9
59	R:R:L124	R:R:L75	5.54	No	No	2	8	9
60	R:R:L75	R:R:N302	5.49	No	Yes	2	9	9
61	R:R:C119	R:R:S78	5.16	Yes	No	2	7	8
62	R:R:F123	R:R:S78	6.61	Yes	No	2	8	8
63	R:R:S78	R:R:W158	4.94	No	Yes	2	8	9
64	R:R:D79	R:R:S299	7.36	Yes	No	0	9	8
65	R:R:D79	R:R:N302	8.08	Yes	Yes	0	9	9
66	R:R:L81	R:R:N116	13.73	No	No	0	7	8
67	R:R:F113	R:R:Y82	15.47	Yes	Yes	0	6	7
68	R:R:L117	R:R:Y82	7.03	No	Yes	0	7	7
69	R:R:S296	R:R:Y82	5.09	No	Yes	0	7	7
70	R:R:S299	R:R:Y82	8.9	No	Yes	0	8	7
71	R:R:L112	R:R:S85	4.5	No	No	0	5	7
72	R:R:F113	R:R:S85	3.96	Yes	No	0	6	7
73	R:R:P87	R:R:Y91	6.95	No	No	0	9	5
74	R:R:L88	R:R:W99	5.69	No	Yes	0	7	8
75	R:R:L105	R:R:L88	4.15	No	No	0	6	7
76	R:R:L88	R:R:V109	10.43	No	No	0	7	5
77	R:R:F113	R:R:L89	4.87	Yes	No	0	6	6
78	R:R:V90	R:R:Y91	6.31	No	No	0	7	5
79	R:R:Y92	R:R:Y93	11.91	Yes	Yes	1	6	6
80	R:R:D97	R:R:Y92	13.79	Yes	Yes	1	4	6
81	R:R:T182	R:R:Y92	4.99	No	Yes	0	4	6
82	R:R:D97	R:R:Y93	5.75	Yes	Yes	1	4	6
83	R:R:R110	R:R:Y93	4.12	No	Yes	0	6	6
84	R:R:R292	R:R:Y93	4.12	Yes	Yes	1	6	6
85	R:R:P100	R:R:R95	7.21	No	No	0	3	5
86	R:R:H98	R:R:V181	4.15	No	No	0	5	4
87	R:R:P100	R:R:W99	6.76	No	Yes	0	3	8
88	R:R:F101	R:R:W99	8.02	No	Yes	0	7	8
89	R:R:C106	R:R:W99	9.14	No	Yes	1	9	8
90	R:R:C183	R:R:W99	5.22	No	Yes	1	9	8
91	R:R:F101	R:R:L105	8.53	No	No	0	7	6
92	R:R:K107	R:R:T103	4.5	No	No	0	6	3
93	R:R:T103	R:R:T174	12.56	No	No	0	3	5
94	R:R:C106	R:R:C183	7.28	No	No	1	9	9
95	R:R:K107	R:R:V172	4.55	No	No	0	6	5
96	R:R:R110	R:R:V172	5.23	No	No	0	6	5
97	R:R:D185	R:R:R110	11.91	No	No	0	4	6
98	R:R:F111	R:R:T115	7.78	Yes	No	0	6	5
99	R:R:F111	R:R:L169	8.53	Yes	No	0	6	5
100	R:R:L112	R:R:N116	5.49	No	No	0	5	8
101	R:R:F113	R:R:Y114	10.32	Yes	No	0	6	5
102	R:R:D185	R:R:Y114	11.49	No	No	0	4	5
103	R:R:R265	R:R:Y114	11.32	No	No	0	6	5
104	R:R:Q165	R:R:T115	5.67	No	No	0	7	5
105	R:R:L117	R:R:Y118	8.21	No	Yes	0	7	7
106	R:R:Q165	R:R:Y118	9.02	No	Yes	0	7	7
107	R:R:L206	R:R:Y118	8.21	No	Yes	0	6	7
108	R:R:H262	R:R:Y118	6.53	Yes	Yes	0	8	7
109	R:R:C119	R:R:F123	5.59	Yes	Yes	2	7	8
110	R:R:C119	R:R:W158	9.14	Yes	Yes	2	7	9
111	R:R:C119	R:R:V161	6.83	Yes	No	0	7	7
112	R:R:F258	R:R:I121	12.56	No	No	0	9	8
113	R:R:L122	R:R:L206	4.15	No	No	0	6	6
114	R:R:F123	R:R:V157	5.24	Yes	No	0	8	7
115	R:R:F123	R:R:W158	10.02	Yes	Yes	2	8	9
116	R:R:L124	R:R:N302	8.24	No	Yes	2	8	9
117	R:R:L124	R:R:Y306	4.69	No	Yes	2	8	9
118	R:R:P210	R:R:T125	6.99	No	No	0	9	7
119	R:R:I214	R:R:T125	9.12	No	No	0	7	7
120	R:R:I127	R:R:R131	6.26	No	No	2	9	9
121	R:R:I127	R:R:Y306	7.25	No	Yes	2	9	9
122	R:R:I214	R:R:S128	9.29	No	No	0	7	9
123	R:R:S128	R:R:Y218	13.99	No	Yes	0	9	9
124	R:R:R131	R:R:Y218	8.23	No	Yes	0	9	9
125	R:R:R131	R:R:Y306	8.23	No	Yes	2	9	9
126	R:R:C132	R:R:C217	7.28	No	No	0	8	8
127	R:R:L133	R:R:S141	6.01	No	No	0	5	5
128	R:R:M221	R:R:V135	10.65	No	No	0	8	8
129	R:R:L225	R:R:V135	4.47	No	No	0	8	8
130	R:R:R140	R:R:W144	12	No	No	0	4	4
131	R:R:R148	R:R:R151	6.4	No	No	0	4	2
132	R:R:P167	R:R:Y198	16.69	No	No	0	8	4
133	R:R:F171	R:R:Y170	8.25	Yes	No	1	5	4
134	R:R:R194	R:R:Y170	5.14	No	No	1	4	4
135	R:R:F171	R:R:S187	5.28	Yes	No	1	5	5
136	R:R:F171	R:R:R194	6.41	Yes	No	1	5	4
137	R:R:F171	R:R:F195	15	Yes	Yes	1	5	2
138	R:R:F171	R:R:Y198	6.19	Yes	No	0	5	4
139	R:R:H184	R:R:S175	5.58	No	No	0	4	2
140	R:R:R177	R:R:R180	6.4	No	No	0	3	2
141	R:R:R180	R:R:T182	5.17	No	No	0	2	4
142	R:R:H184	R:R:P189	6.1	No	No	0	4	3
143	R:R:F192	R:R:T186	5.19	No	Yes	1	2	3
144	R:R:F195	R:R:T186	7.78	Yes	Yes	1	2	3
145	R:R:T186	R:R:Y269	4.99	Yes	Yes	0	3	5
146	R:R:R272	R:R:T186	6.47	Yes	Yes	1	3	3
147	R:R:L191	R:R:S187	4.5	No	No	0	3	5
148	R:R:F195	R:R:S187	6.61	Yes	No	1	2	5
149	R:R:A188	R:R:E190	4.53	No	No	0	5	1
150	R:R:E190	R:R:L191	5.3	No	No	0	1	3
151	R:R:L191	R:R:R194	6.07	No	No	0	3	4
152	R:R:F192	R:R:V196	5.24	No	No	0	2	3
153	R:R:F192	R:R:R272	14.97	No	Yes	1	2	3
154	R:R:F195	R:R:S199	3.96	Yes	No	0	2	5
155	R:R:M202	R:R:Y198	9.58	Yes	No	0	6	4
156	R:R:S199	R:R:Y269	5.09	No	Yes	0	5	5
157	R:R:L206	R:R:M202	4.24	No	Yes	0	6	6
158	R:R:L203	R:R:T266	7.37	No	No	0	5	5
159	R:R:F207	R:R:H262	32.81	No	Yes	0	8	8
160	R:R:F211	R:R:F254	6.43	No	No	0	6	9
161	R:R:L215	R:R:L251	4.15	No	No	0	5	8
162	R:R:I247	R:R:Y218	6.04	No	Yes	0	8	9
163	R:R:V250	R:R:Y218	6.31	No	Yes	0	8	9
164	R:R:I247	R:R:M221	5.83	No	No	0	8	8
165	R:R:G231	R:R:Y230	5.79	No	No	0	4	3
166	R:R:L236	R:R:P237	4.93	No	No	0	3	3
167	R:R:K240	R:R:L236	4.23	No	No	0	6	3
168	R:R:K242	R:R:R245	7.43	No	No	0	7	5
169	R:R:R245	R:R:T246	5.17	No	No	0	5	7
170	R:R:L305	R:R:V249	4.47	No	No	0	8	4
171	R:R:L305	R:R:V250	4.47	No	No	0	8	8
172	R:R:L305	R:R:V253	5.96	No	No	0	8	7
173	R:R:F254	R:R:F258	7.5	No	No	0	9	9
174	R:R:C257	R:R:N298	9.45	No	No	0	8	9
175	R:R:F258	R:R:N298	14.5	No	No	0	9	9
176	R:R:F261	R:R:H262	7.92	Yes	Yes	0	7	8
177	R:R:F261	R:R:Y288	6.19	Yes	Yes	1	7	5
178	R:R:F261	R:R:R292	4.28	Yes	Yes	1	7	6
179	R:R:A295	R:R:F261	8.32	No	Yes	0	8	7
180	R:R:T264	R:R:Y288	4.99	No	Yes	0	5	5
181	R:R:T264	R:R:T291	12.56	No	No	0	5	7
182	R:R:R265	R:R:Y269	10.29	No	Yes	0	6	5
183	R:R:R265	R:R:Y288	7.2	No	Yes	0	6	5
184	R:R:Y268	R:R:Y269	4.96	Yes	Yes	0	4	5
185	R:R:R272	R:R:Y268	18.52	Yes	Yes	1	3	4
186	R:R:Y268	R:R:Y288	10.92	Yes	Yes	1	4	5
187	R:R:F271	R:R:L276	4.87	No	Yes	0	3	1
188	R:R:F271	R:R:I284	6.28	No	No	0	3	5
189	R:R:L276	R:R:T280	11.79	Yes	No	1	1	2
190	R:R:L276	R:R:L281	4.15	Yes	No	1	1	1
191	R:R:H279	R:R:S277	5.58	No	No	0	3	6
192	R:R:L281	R:R:T280	5.9	No	No	1	1	2
193	R:R:K289	R:R:N285	15.39	Yes	No	1	5	3
194	R:R:R292	R:R:Y288	19.55	Yes	Yes	1	6	5
195	R:R:K289	R:R:R292	7.43	Yes	Yes	1	5	6
196	R:R:N298	R:R:N302	8.17	No	Yes	0	9	9
197	R:R:F111	R:R:V168	3.93	Yes	No	0	6	4
198	R:R:W99	R:R:Y92	3.86	Yes	Yes	1	8	6
199	R:R:H262	R:R:L203	3.86	Yes	No	0	8	5
200	R:R:V153	R:R:Y149	3.79	No	No	0	5	3
201	R:R:C44	R:R:P87	3.77	Yes	No	0	7	9
202	R:R:F307	R:R:I57	3.77	No	No	0	7	7
203	R:R:I57	R:R:R61	3.76	No	No	0	7	4
204	R:R:A94	R:R:P37	3.74	No	No	0	5	5
205	R:R:F73	R:R:L59	3.65	No	No	0	6	3
206	R:R:F207	R:R:L259	3.65	No	No	0	8	6
207	R:R:F271	R:R:L267	3.65	No	No	0	3	4
208	R:R:L136	R:R:R224	3.64	Yes	No	0	7	5
209	R:R:L142	R:R:R143	3.64	No	No	0	5	3
210	R:R:L142	R:R:R146	3.64	No	Yes	0	5	7
211	R:R:D275	R:R:R24	3.57	No	No	0	1	2
212	R:R:P210	R:R:V209	3.53	No	No	0	9	5
213	R:R:L86	R:R:Y40	3.52	No	Yes	0	8	8
214	R:R:L251	R:R:Y218	3.52	No	Yes	0	8	9
215	R:R:K63	R:R:W65	3.48	No	Yes	0	5	6
216	R:R:C217	R:R:V129	3.42	No	No	0	8	6
217	R:R:G204	R:R:L203	3.42	No	No	0	5	5
218	R:R:A222	R:R:V244	3.39	No	No	0	5	6
219	R:R:K227	R:R:P228	3.35	No	No	0	3	6
220	R:R:L36	R:R:P293	3.28	No	No	0	5	5
221	R:R:L139	R:R:P138	3.28	No	No	0	5	7
222	R:R:L259	R:R:P260	3.28	No	No	0	6	9
223	R:R:H130	R:R:Y71	3.27	No	Yes	0	8	7
224	R:R:A222	R:R:I247	3.25	No	No	0	5	8
225	R:R:C164	R:R:M202	3.24	No	Yes	0	5	6
226	R:R:S102	R:R:V104	3.23	No	No	0	7	2
227	R:R:C44	R:R:L48	3.17	Yes	No	0	7	6
228	R:R:T125	R:R:V213	3.17	No	No	0	7	7
229	R:R:C132	R:R:L136	3.17	No	Yes	0	8	7
230	R:R:C164	R:R:L160	3.17	No	No	0	5	4
231	R:R:A83	R:R:L48	3.15	No	No	0	6	6
232	R:R:E190	R:R:P189	3.14	No	No	0	1	3
233	R:R:R152	R:R:Y149	3.09	No	No	0	3	3
234	R:R:M286	R:R:V290	3.04	No	No	0	1	4
235	R:R:L133	R:R:V129	2.98	No	No	0	5	6
236	R:R:L136	R:R:V135	2.98	Yes	No	0	7	8
237	R:R:L220	R:R:V216	2.98	No	No	0	4	4
238	R:R:L226	R:R:V244	2.98	No	No	0	3	6
239	R:R:L259	R:R:V263	2.98	No	No	0	6	6
240	R:R:D79	R:R:S120	2.94	Yes	No	0	9	9
241	R:R:K240	R:R:L225	2.82	No	No	0	6	8
242	R:R:C25	R:R:F27	2.79	No	Yes	0	9	2
243	R:R:P37	R:R:Y93	2.78	No	Yes	0	5	6
244	R:R:A67	R:R:R146	2.77	No	Yes	0	7	7
245	R:R:R223	R:R:V219	2.62	No	No	0	3	4
246	R:R:F58	R:R:I57	2.51	No	No	0	7	7
247	R:R:V77	R:R:W158	2.45	No	Yes	0	6	9
248	R:R:F73	R:R:L55	2.44	No	No	0	6	7
249	R:R:F111	R:R:L162	2.44	Yes	No	0	6	3
250	R:R:L236	R:R:R241	2.43	No	No	0	3	4
251	R:R:L308	R:R:R245	2.43	No	No	0	7	5
252	R:R:G178	R:R:G179	2.11	No	No	0	3	4
253	R:R:G234	R:R:G235	2.11	No	No	0	4	3
254	R:R:R146	R:R:W144	2	Yes	No	0	7	4
255	R:R:C44	R:R:G41	1.96	Yes	No	0	7	5
256	R:R:C300	R:R:G47	1.96	No	No	0	8	8
257	R:R:A154	R:R:G155	1.95	No	No	0	7	3
258	R:R:A208	R:R:G204	1.95	No	No	0	5	5
259	R:R:A166	R:R:P167	1.87	No	No	0	4	8
260	R:R:A297	R:R:C300	1.81	No	No	0	6	8
261	R:R:A54	R:R:A76	1.79	No	No	0	9	9
262	R:R:C49	R:R:V45	1.71	No	No	0	4	5
263	R:R:G47	R:R:L46	1.71	No	No	0	8	6
264	R:R:A176	R:R:V181	1.7	No	No	0	2	4
265	R:R:D97	R:R:G96	1.68	Yes	No	0	4	3
266	R:R:A188	R:R:T173	1.68	No	No	0	5	4
267	R:R:A229	R:R:T232	1.68	No	No	0	4	4
268	R:R:A287	R:R:T264	1.68	No	No	0	5	5
269	R:R:V38	R:R:V42	1.6	No	No	0	5	5
270	R:R:S270	R:R:T266	1.6	No	No	0	5	5
271	R:R:S277	R:R:T280	1.6	No	No	0	6	2
272	R:R:T246	R:R:V250	1.59	No	No	0	7	8
273	R:R:C257	R:R:L256	1.59	No	No	0	8	6
274	R:R:C257	R:R:L301	1.59	No	No	0	8	7
275	R:R:A76	R:R:L55	1.58	No	No	0	9	7
276	R:R:M202	R:R:V201	1.52	Yes	No	0	6	3
277	R:R:L105	R:R:S102	1.5	No	No	0	6	7
278	R:R:G145	R:R:R146	1.5	No	Yes	0	7	7
279	R:R:L225	R:R:S243	1.5	No	No	0	8	7
280	R:R:L274	R:R:S273	1.5	No	No	0	1	1
281	R:R:L50	R:R:V304	1.49	No	No	0	8	7
282	R:R:L205	R:R:V201	1.49	No	No	0	4	3
283	R:R:L215	R:R:V219	1.49	No	No	0	5	4
284	R:R:L62	R:R:T64	1.47	No	No	0	5	6
285	R:R:P138	R:R:R137	1.44	No	No	0	7	7
286	R:R:A255	R:R:F211	1.39	No	No	0	5	6
287	R:R:A156	R:R:R152	1.38	No	No	0	4	3
288	R:R:L256	R:R:L294	1.38	No	No	0	6	7
289	R:R:L274	R:R:L276	1.38	No	Yes	0	1	1
290	R:R:V53	R:R:Y56	1.26	No	No	0	6	4
291	R:R:K227	R:R:R224	1.24	No	No	0	3	5
292	R:R:F27	R:R:N282	1.21	Yes	No	0	2	3
293	R:R:L136	R:R:R137	1.21	Yes	No	0	7	7
294	R:R:L139	R:R:R143	1.21	No	No	0	5	3
295	R:R:D30	R:R:Y33	1.15	No	No	0	3	5
296	R:R:L62	R:R:W65	1.14	No	Yes	0	5	6
297	R:R:H98	R:R:R95	1.13	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	13.777	10	1	0
2	R:R:F27	8.505	6	1	2
3	R:R:E29	10.2	4	1	2
4	R:R:K32	8.44	6	1	3
5	R:R:Y40	4.355	4	0	8
6	R:R:C44	3.8125	4	0	7
7	R:R:W65	6.884	5	0	6
8	R:R:Y71	5.8	5	0	7
9	R:R:D79	6.615	4	0	9
10	R:R:Y82	9.1225	4	0	7
11	R:R:Y92	8.6375	4	1	6
12	R:R:Y93	5.95	8	1	6
13	R:R:D97	7.38	4	1	4
14	R:R:W99	6.44833	6	1	8
15	R:R:F111	5.67	4	0	6
16	R:R:F113	8.655	4	0	6
17	R:R:Y118	7.9925	4	0	7
18	R:R:C119	6.68	4	2	7
19	R:R:F123	7.28833	6	2	8
20	R:R:L136	2.75	4	0	7
21	R:R:R146	2.4775	4	0	7
22	R:R:W158	6.792	5	2	9
23	R:R:F171	8.226	5	1	5
24	R:R:T186	7	5	1	3
25	R:R:F195	8.3375	4	1	2
26	R:R:M202	4.645	4	0	6
27	R:R:Y218	7.618	5	0	9
28	R:R:F261	6.6775	4	1	7
29	R:R:H262	12.78	4	0	8
30	R:R:Y268	9.8925	4	1	4
31	R:R:Y269	6.3325	4	0	5
32	R:R:R272	14.1775	4	1	3
33	R:R:L276	5.5475	4	1	1
34	R:R:Y288	9.77	5	1	5
35	R:R:K289	9.746	5	1	5
36	R:R:R292	8.035	6	1	6
37	R:R:N302	7.495	4	2	9
38	R:R:Y306	6.8375	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F27	24.6933	25.53	Yes	Yes	1	0	2
2	R:R:F27	R:R:L281	15.2805	6.09	Yes	No	1	2	1
3	L:L:?1	R:R:R292	23.411	8.71	Yes	Yes	1	0	6
4	R:R:R292	R:R:Y40	46.4211	4.12	Yes	Yes	0	6	8
5	R:R:S296	R:R:Y40	45.2499	5.09	No	Yes	0	7	8
6	L:L:?1	R:R:D185	20.4335	8.23	Yes	No	0	0	4
7	R:R:D185	R:R:Y114	22.4384	11.49	No	No	0	4	5
8	R:R:F113	R:R:Y114	36.381	10.32	Yes	No	0	6	5
9	R:R:F113	R:R:Y82	36.4127	15.47	Yes	Yes	0	6	7
10	R:R:S299	R:R:Y82	100	8.9	No	Yes	0	8	7
11	R:R:D79	R:R:S299	99.5157	7.36	Yes	No	0	9	8
12	R:R:S296	R:R:Y82	45.8216	5.09	No	Yes	0	7	7
13	R:R:D79	R:R:N302	95.903	8.08	Yes	Yes	0	9	9
14	R:R:L124	R:R:N302	78.5224	8.24	No	Yes	2	8	9
15	R:R:L124	R:R:Y306	81.2934	4.69	No	Yes	2	8	9
16	R:R:I127	R:R:Y306	31.4582	7.25	No	Yes	2	9	9
17	R:R:I127	R:R:Y71	34.6699	4.84	No	Yes	0	9	7
18	R:R:A150	R:R:Y71	17.8808	4	No	Yes	0	8	7
19	R:R:A150	R:R:T70	16.6303	5.03	No	No	0	8	7
20	R:R:T70	R:R:W65	15.3718	4.85	No	Yes	0	7	6
21	R:R:H130	R:R:Y71	11.1199	3.27	No	Yes	0	8	7
22	R:R:L75	R:R:N302	10.9135	5.49	No	Yes	2	9	9
23	R:R:F123	R:R:L75	13.1367	6.09	Yes	No	2	8	9
24	R:R:L117	R:R:Y82	23.4269	7.03	No	Yes	0	7	7
25	R:R:F261	R:R:R292	10.0322	4.28	Yes	Yes	1	7	6
26	R:R:F261	R:R:H262	10.584	7.92	Yes	Yes	0	7	8
27	R:R:H262	R:R:Y118	12.2514	6.53	Yes	Yes	0	8	7
28	R:R:L117	R:R:Y118	22.9624	8.21	No	Yes	0	7	7
29	R:R:Y92	R:R:Y93	21.2434	11.91	Yes	Yes	1	6	6
30	R:R:W99	R:R:Y92	19.1631	3.86	Yes	Yes	1	8	6
31	L:L:?1	R:R:T186	21.565	10.57	Yes	Yes	1	0	3
32	R:R:R265	R:R:Y269	12.5055	10.29	No	Yes	0	6	5
33	R:R:L206	R:R:Y118	17.1146	8.21	No	Yes	0	6	7
34	R:R:N298	R:R:N302	13.1367	8.17	No	Yes	0	9	9
35	R:R:R131	R:R:Y306	45.369	8.23	No	Yes	2	9	9
36	R:R:R131	R:R:Y218	48.7713	8.23	No	Yes	0	9	9
37	R:R:I247	R:R:Y218	28.2941	6.04	No	Yes	0	8	9
38	R:R:I247	R:R:M221	23.6175	5.83	No	No	0	8	8
39	R:R:M221	R:R:V135	22.4503	10.65	No	No	0	8	8
40	R:R:L136	R:R:V135	14.4071	2.98	Yes	No	0	7	8
41	R:R:F195	R:R:T186	22.4344	7.78	Yes	Yes	1	2	3
42	R:R:F171	R:R:Y198	13.355	6.19	Yes	No	0	5	4
43	R:R:F195	R:R:S187	19.4331	6.61	Yes	No	1	2	5
44	R:R:L191	R:R:S187	20.9258	4.5	No	No	0	3	5
45	R:R:E190	R:R:L191	21.291	5.3	No	No	0	1	3
46	R:R:E190	R:R:P189	10.6554	3.14	No	No	0	1	3
47	R:R:M202	R:R:Y198	13.3669	9.58	Yes	No	0	6	4
48	R:R:V250	R:R:Y218	10.576	6.31	No	Yes	0	8	9
49	R:R:R265	R:R:Y114	14.3078	11.32	No	No	0	6	5
50	R:R:R292	R:R:Y93	22.5138	4.12	Yes	Yes	1	6	6
51	R:R:L206	R:R:M202	15.4631	4.24	No	Yes	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y23	37.5	1	Yes	No	0	6	0	1
L:L:?1	R:R:F27	25.53	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:E29	7.31	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:Y93	7.11	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:D185	8.23	1	Yes	No	0	4	0	1
L:L:?1	R:R:T186	10.57	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y268	5.17	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R272	16.75	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:K289	10.89	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R292	8.71	1	Yes	Yes	0	6	0	1
R:R:L21	R:R:Y23	4.69	0	No	No	3	6	2	1
R:R:E29	R:R:F27	8.16	1	Yes	Yes	2	2	1	1
R:R:F27	R:R:L281	6.09	1	Yes	No	2	1	1	2
R:R:F27	R:R:N285	7.25	1	Yes	No	2	3	1	2
R:R:E29	R:R:K32	13.5	1	Yes	Yes	2	3	1	2
R:R:E29	R:R:N285	11.83	1	Yes	No	2	3	1	2
R:R:F31	R:R:K289	4.96	0	No	Yes	5	5	2	1
R:R:K32	R:R:L36	5.64	1	Yes	No	3	5	2	2
R:R:K32	R:R:Y93	4.78	1	Yes	Yes	3	6	2	1
R:R:D97	R:R:K32	8.3	1	Yes	Yes	4	3	2	2
R:R:K289	R:R:K32	10.06	1	Yes	Yes	5	3	1	2
R:R:L36	R:R:Y93	7.03	1	No	Yes	5	6	2	1
R:R:R292	R:R:Y40	4.12	1	Yes	Yes	6	8	1	2
R:R:Y92	R:R:Y93	11.91	1	Yes	Yes	6	6	2	1
R:R:D97	R:R:Y92	13.79	1	Yes	Yes	4	6	2	2
R:R:D97	R:R:Y93	5.75	1	Yes	Yes	4	6	2	1
R:R:R110	R:R:Y93	4.12	0	No	Yes	6	6	2	1
R:R:R292	R:R:Y93	4.12	1	Yes	Yes	6	6	1	1
R:R:D185	R:R:R110	11.91	0	No	No	4	6	1	2
R:R:D185	R:R:Y114	11.49	0	No	No	4	5	1	2
R:R:F192	R:R:T186	5.19	1	No	Yes	2	3	2	1
R:R:F195	R:R:T186	7.78	1	Yes	Yes	2	3	2	1
R:R:T186	R:R:Y269	4.99	1	Yes	Yes	3	5	1	2
R:R:R272	R:R:T186	6.47	1	Yes	Yes	3	3	1	1
R:R:F192	R:R:R272	14.97	1	No	Yes	2	3	2	1
R:R:F261	R:R:Y288	6.19	1	Yes	Yes	7	5	2	2
R:R:F261	R:R:R292	4.28	1	Yes	Yes	7	6	2	1
R:R:Y268	R:R:Y269	4.96	1	Yes	Yes	4	5	1	2
R:R:R272	R:R:Y268	18.52	1	Yes	Yes	3	4	1	1
R:R:Y268	R:R:Y288	10.92	1	Yes	Yes	4	5	1	2
R:R:K289	R:R:N285	15.39	1	Yes	No	5	3	1	2
R:R:R292	R:R:Y288	19.55	1	Yes	Yes	6	5	1	2
R:R:K289	R:R:R292	7.43	1	Yes	Yes	5	6	1	1
R:R:C25	R:R:F27	2.79	0	No	Yes	9	2	2	1
R:R:P37	R:R:Y93	2.78	0	No	Yes	5	6	2	1
R:R:F27	R:R:N282	1.21	1	Yes	No	2	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K20_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.96
Number of Linked Nodes	269
Number of Links	297
Number of Hubs	38
Number of Links mediated by Hubs	143
Number of Communities	2
Number of Nodes involved in Communities	39
Number of Links involved in Communities	62

Path Summary
Number Of Nodes in MetaPath	52
Number Of Links MetaPath	51
Number of Shortest Paths	45409
Length Of Smallest Path	3
Average Path Length	13.062
Length of Longest Path	29
Minimum Path Strength	1.305
Average Path Strength	7.21792
Maximum Path Strength	31.515
Minimum Path Correlation	0.7
Average Path Correlation	0.937072
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	56.7056
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.2201
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled pyrimidinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled UTP receptor activity • A1 adenosine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of localization • regulation of body fluid levels • multicellular organismal process
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • regulation of localization • regulation of body fluid levels • multicellular organismal process • secretion by tissue • regulation of transport • transport • secretion • regulation of mucus secretion • positive regulation of biological process • establishment of localization • mucus secretion • regulation of secretion • localization • body fluid secretion • positive regulation of secretion • positive regulation of transport • positive regulation of mucus secretion • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of biological quality • cellular homeostasis • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • cellular response to nitrogen compound • cellular response to ATP • response to organophosphorus • response to oxygen-containing compound • response to nitrogen compound • response to ATP • response to purine-containing compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • response to chemical • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic nucleotide receptor signaling pathway • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • synapse • cell junction • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • mu-type opioid receptor binding • signaling receptor binding • G protein-coupled receptor binding • opioid receptor binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • cation binding • metal ion binding • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • heart process • regulation of heart contraction • regulation of system process • regulation of blood circulation • heart contraction • behavior • locomotory behavior • export from cell • membrane docking • vesicle-mediated transport • organelle localization by membrane tethering • secretion by cell • exocytosis • organelle localization • vesicle docking • exocytic process • vesicle docking involved in exocytosis • negative regulation of protein transport • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • regulation of protein secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of peptide transport • regulation of establishment of protein localization • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • trans-synaptic signaling • modulation of chemical synaptic transmission • chemical synaptic transmission • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • postsynaptic modulation of chemical synaptic transmission • muscle contraction • muscle system process • postsynapse • postsynaptic membrane • plasma membrane region • synaptic membrane • parallel fiber to Purkinje cell synapse • excitatory synapse • presynapse • presynaptic membrane • somatodendritic compartment • dendrite • dendritic tree • GABA-ergic synapse • glutamatergic synapse • cell body
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ATP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ATP
Name	ATP
Synonyms	Adenosine triphosphate disodium trihydrate
Identifier
Formula	C10 H16 N5 O13 P3
Molecular Weight	507.181
SMILES
PubChem	5957
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	6
Total Bonds	49
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41231
Sequence	>9K20_nogp_Chain_R L G Y R C R F N E D F K Y V L L P V S Y G V V C V G L C L N A V A L Y I F L C R L K T W N A S T T Y M F H L A V S D A L Y A A S L P L L V Y Y Y A R G D H W P F S T V L C K L V R F L F Y T N L Y C S I L F L T C I S V H R C L G V L R P L R S L R W G R A R Y A R R V A G A V W V L V L A C Q A P V L Y F V T T S A R G G R V T C H D T S A P E L F S R F V A Y S S V M L G L L F A V P F A V I L V C Y V L M A R R L L K P A Y G T S G G L P R A K R K S V R T I A V V L A V F A L C F L P F H V T R T L Y Y S F R S L D L S C H T L N A I N M A Y K V T R P L A S A N S C L P V L Y F L L N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K20	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-	chim(NtGi1-Go)/β1/γ2	2.65	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K20 (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-		2.65	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0X	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.83	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0X (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-		2.83	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K25	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.31	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K25 (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	-	-		3.31	2025-06-11	doi.org/10.1038/s41421-025-00797-x

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