psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y23	32.33	Yes	No	0	0	6
2	L:L:?1	R:R:F27	20.83	Yes	Yes	1	0	2
3	L:L:?1	R:R:E29	8.04	Yes	Yes	1	0	2
4	L:L:?1	R:R:K32	3.89	Yes	Yes	1	0	3
5	L:L:?1	R:R:D185	7.49	Yes	Yes	1	0	4
6	L:L:?1	R:R:T186	12.2	Yes	Yes	1	0	3
7	L:L:?1	R:R:Y268	6.47	Yes	Yes	1	0	4
8	L:L:?1	R:R:R272	10.05	Yes	Yes	1	0	3
9	L:L:?1	R:R:K289	8.56	Yes	Yes	1	0	5
10	L:L:?1	R:R:R292	9.38	Yes	Yes	1	0	6
11	R:R:L21	R:R:R177	12.15	No	No	0	3	3
12	R:R:C25	R:R:R24	4.18	No	No	0	9	2
13	R:R:C25	R:R:C278	7.28	No	No	0	9	7
14	R:R:E29	R:R:F27	4.66	Yes	Yes	1	2	2
15	R:R:F27	R:R:Y268	6.19	Yes	Yes	1	2	4
16	R:R:F27	R:R:L281	7.31	Yes	No	0	2	1
17	R:R:F27	R:R:N285	14.5	Yes	No	1	2	3
18	R:R:D30	R:R:N28	10.77	No	No	0	3	5
19	R:R:E29	R:R:K32	9.45	Yes	Yes	1	2	3
20	R:R:D97	R:R:E29	3.9	No	Yes	0	4	2
21	R:R:F31	R:R:M286	9.95	No	No	0	5	1
22	R:R:F31	R:R:K289	4.96	No	Yes	0	5	5
23	R:R:K32	R:R:L36	5.64	Yes	No	0	3	5
24	R:R:K289	R:R:K32	5.75	Yes	Yes	1	5	3
25	R:R:G96	R:R:Y33	4.35	No	No	0	3	5
26	R:R:D97	R:R:Y33	13.79	No	No	0	4	5
27	R:R:L36	R:R:Y93	10.55	No	Yes	0	5	6
28	R:R:A94	R:R:P37	3.74	No	No	0	5	5
29	R:R:L86	R:R:Y40	4.69	No	Yes	0	8	8
30	R:R:Y40	R:R:Y93	4.96	Yes	Yes	1	8	6
31	R:R:R292	R:R:Y40	4.12	Yes	Yes	1	6	8
32	R:R:S296	R:R:Y40	5.09	Yes	Yes	0	7	8
33	R:R:S296	R:R:V43	9.7	Yes	No	0	7	7
34	R:R:C44	R:R:L86	4.76	No	No	0	7	8
35	R:R:C44	R:R:P87	3.77	No	No	0	7	9
36	R:R:D79	R:R:N51	6.73	Yes	No	0	9	9
37	R:R:N51	R:R:P303	6.52	No	No	0	9	9
38	R:R:F73	R:R:L55	3.65	Yes	No	0	6	7
39	R:R:C60	R:R:Y56	5.38	No	No	0	5	4
40	R:R:R61	R:R:Y56	12.35	No	No	0	4	4
41	R:R:F58	R:R:M72	3.73	No	No	4	7	8
42	R:R:F307	R:R:F58	9.65	Yes	No	4	7	7
43	R:R:F73	R:R:L59	3.65	Yes	No	0	6	3
44	R:R:L62	R:R:T64	5.9	No	No	0	5	6
45	R:R:N66	R:R:T64	4.39	No	No	0	7	6
46	R:R:T69	R:R:W65	4.85	No	No	0	7	6
47	R:R:T70	R:R:W65	7.28	No	No	0	7	6
48	R:R:F73	R:R:W65	7.02	Yes	No	0	6	6
49	R:R:N66	R:R:T69	4.39	No	No	0	7	7
50	R:R:A67	R:R:H130	5.85	No	Yes	0	7	8
51	R:R:H130	R:R:S68	8.37	Yes	No	0	8	8
52	R:R:A150	R:R:T70	5.03	No	No	0	8	7
53	R:R:C126	R:R:Y71	9.41	No	Yes	0	6	7
54	R:R:I127	R:R:Y71	3.63	No	Yes	0	9	7
55	R:R:H130	R:R:Y71	4.36	Yes	Yes	0	8	7
56	R:R:A150	R:R:Y71	5.34	No	Yes	0	8	7
57	R:R:V153	R:R:Y71	8.83	No	Yes	0	5	7
58	R:R:F307	R:R:M72	11.2	Yes	No	4	7	8
59	R:R:F73	R:R:V77	5.24	Yes	No	0	6	6
60	R:R:F123	R:R:H74	11.31	No	Yes	3	8	9
61	R:R:H74	R:R:R151	5.64	Yes	No	0	9	2
62	R:R:A154	R:R:H74	7.32	No	Yes	0	7	9
63	R:R:H74	R:R:W158	6.35	Yes	Yes	3	9	9
64	R:R:L124	R:R:L75	5.54	Yes	No	2	8	9
65	R:R:L75	R:R:N302	4.12	No	Yes	2	9	9
66	R:R:C119	R:R:S78	5.16	No	No	3	7	8
67	R:R:S78	R:R:W158	7.41	No	Yes	3	8	9
68	R:R:D79	R:R:S120	4.42	Yes	No	0	9	9
69	R:R:D79	R:R:S299	5.89	Yes	No	0	9	8
70	R:R:D79	R:R:N302	8.08	Yes	Yes	0	9	9
71	R:R:L81	R:R:N116	8.24	No	No	0	7	8
72	R:R:L86	R:R:Y82	8.21	No	Yes	0	8	7
73	R:R:F113	R:R:Y82	15.47	No	Yes	0	6	7
74	R:R:N116	R:R:Y82	5.81	No	Yes	0	8	7
75	R:R:L117	R:R:Y82	4.69	No	Yes	0	7	7
76	R:R:S296	R:R:Y82	3.82	Yes	Yes	0	7	7
77	R:R:S299	R:R:Y82	8.9	No	Yes	0	8	7
78	R:R:L112	R:R:S85	6.01	No	No	0	5	7
79	R:R:L88	R:R:W99	5.69	No	Yes	0	7	8
80	R:R:L88	R:R:V109	4.47	No	No	0	7	5
81	R:R:L89	R:R:V109	4.47	No	No	0	6	5
82	R:R:L89	R:R:R110	7.29	No	Yes	0	6	6
83	R:R:F113	R:R:L89	3.65	No	No	0	6	6
84	R:R:Y92	R:R:Y93	6.95	Yes	Yes	1	6	6
85	R:R:D97	R:R:Y92	8.05	No	Yes	0	4	6
86	R:R:W99	R:R:Y92	7.72	Yes	Yes	1	8	6
87	R:R:C183	R:R:Y92	8.06	Yes	Yes	1	9	6
88	R:R:R292	R:R:Y93	5.14	Yes	Yes	1	6	6
89	R:R:H98	R:R:R95	4.51	Yes	No	0	5	5
90	R:R:H98	R:R:P100	18.3	Yes	No	0	5	3
91	R:R:H98	R:R:R180	6.77	Yes	No	0	5	2
92	R:R:H98	R:R:V181	4.15	Yes	No	0	5	4
93	R:R:F101	R:R:W99	11.02	Yes	Yes	1	7	8
94	R:R:L105	R:R:W99	5.69	No	Yes	1	6	8
95	R:R:C106	R:R:W99	5.22	No	Yes	1	9	8
96	R:R:C183	R:R:W99	14.37	Yes	Yes	1	9	8
97	R:R:F101	R:R:L105	3.65	Yes	No	1	7	6
98	R:R:L105	R:R:S102	4.5	No	No	0	6	7
99	R:R:T103	R:R:T174	7.85	No	No	0	3	5
100	R:R:C106	R:R:C183	7.28	No	Yes	1	9	9
101	R:R:R110	R:R:V172	7.85	Yes	No	0	6	5
102	R:R:C183	R:R:R110	5.57	Yes	Yes	0	9	6
103	R:R:D185	R:R:R110	21.44	Yes	Yes	0	4	6
104	R:R:F111	R:R:T115	7.78	No	No	0	6	5
105	R:R:F111	R:R:L169	12.18	No	No	0	6	5
106	R:R:L112	R:R:N116	6.87	No	No	0	5	8
107	R:R:F113	R:R:Y114	7.22	No	No	0	6	5
108	R:R:D185	R:R:Y114	8.05	Yes	No	0	4	5
109	R:R:R265	R:R:Y114	12.35	No	No	0	6	5
110	R:R:Q165	R:R:Y118	9.02	No	No	0	7	7
111	R:R:L206	R:R:Y118	9.38	No	No	0	6	7
112	R:R:H262	R:R:Y118	7.62	Yes	No	0	8	7
113	R:R:C119	R:R:W158	5.22	No	Yes	3	7	9
114	R:R:C119	R:R:V161	5.12	No	No	0	7	7
115	R:R:F254	R:R:I121	3.77	Yes	No	2	9	8
116	R:R:F258	R:R:I121	15.07	No	No	2	9	8
117	R:R:F123	R:R:V157	7.87	No	No	0	8	7
118	R:R:F123	R:R:W158	9.02	No	Yes	3	8	9
119	R:R:F254	R:R:L124	4.87	Yes	Yes	2	9	8
120	R:R:L124	R:R:N302	8.24	Yes	Yes	2	8	9
121	R:R:L124	R:R:Y306	5.86	Yes	Yes	2	8	9
122	R:R:P210	R:R:T125	5.25	No	No	0	9	7
123	R:R:I214	R:R:T125	6.08	No	No	0	7	7
124	R:R:I127	R:R:R131	7.52	No	No	2	9	9
125	R:R:I127	R:R:Y306	4.84	No	Yes	2	9	9
126	R:R:I214	R:R:S128	6.19	No	No	0	7	9
127	R:R:S128	R:R:Y218	6.36	No	No	0	9	9
128	R:R:H130	R:R:R146	12.41	Yes	Yes	0	8	7
129	R:R:R131	R:R:Y218	8.23	No	No	0	9	9
130	R:R:R131	R:R:Y306	6.17	No	Yes	2	9	9
131	R:R:C132	R:R:C217	7.28	No	No	0	8	8
132	R:R:L133	R:R:R146	6.07	No	Yes	0	5	7
133	R:R:M221	R:R:V135	10.65	No	No	0	8	8
134	R:R:L136	R:R:L220	4.15	No	No	0	7	4
135	R:R:L136	R:R:R224	18.22	No	No	0	7	5
136	R:R:R137	R:R:R140	11.73	No	No	0	7	4
137	R:R:P138	R:R:R140	4.32	No	No	0	7	4
138	R:R:L139	R:R:R140	3.64	No	No	0	5	4
139	R:R:S141	R:R:W144	3.71	Yes	No	5	5	4
140	R:R:R146	R:R:S141	7.91	Yes	Yes	5	7	5
141	R:R:R146	R:R:W144	4	Yes	No	5	7	4
142	R:R:C164	R:R:M202	6.48	No	No	0	5	6
143	R:R:Q165	R:R:V168	4.3	No	No	0	7	4
144	R:R:P167	R:R:Y198	16.69	No	Yes	0	8	4
145	R:R:V168	R:R:Y198	3.79	No	Yes	0	4	4
146	R:R:R194	R:R:Y170	6.17	Yes	No	0	4	4
147	R:R:F171	R:R:S187	6.61	Yes	No	1	5	5
148	R:R:F171	R:R:L191	3.65	Yes	No	1	5	3
149	R:R:F171	R:R:R194	6.41	Yes	Yes	1	5	4
150	R:R:F171	R:R:F195	12.86	Yes	Yes	1	5	2
151	R:R:F171	R:R:Y198	7.22	Yes	Yes	0	5	4
152	R:R:R177	R:R:T182	5.17	No	No	0	3	4
153	R:R:G179	R:R:R180	6	No	No	0	4	2
154	R:R:H184	R:R:T182	4.11	No	No	0	4	4
155	R:R:D185	R:R:R292	4.76	Yes	Yes	1	4	6
156	R:R:F195	R:R:T186	3.89	Yes	Yes	1	2	3
157	R:R:T186	R:R:Y269	9.99	Yes	Yes	1	3	5
158	R:R:R272	R:R:T186	10.35	Yes	Yes	1	3	3
159	R:R:F195	R:R:S187	3.96	Yes	No	1	2	5
160	R:R:L191	R:R:R194	8.5	No	Yes	1	3	4
161	R:R:F192	R:R:R272	12.83	No	Yes	0	2	3
162	R:R:F192	R:R:S273	7.93	No	No	0	2	1
163	R:R:F195	R:R:S199	3.96	Yes	No	1	2	5
164	R:R:F195	R:R:Y269	7.22	Yes	Yes	1	2	5
165	R:R:S273	R:R:V196	4.85	No	No	0	1	3
166	R:R:M202	R:R:Y198	10.78	No	Yes	0	6	4
167	R:R:S199	R:R:Y269	3.82	No	Yes	1	5	5
168	R:R:H262	R:R:L203	3.86	Yes	No	0	8	5
169	R:R:L203	R:R:T266	7.37	No	No	0	5	5
170	R:R:F207	R:R:F211	6.43	No	Yes	2	8	6
171	R:R:F207	R:R:L259	3.65	No	Yes	2	8	6
172	R:R:F207	R:R:H262	30.55	No	Yes	0	8	8
173	R:R:F211	R:R:F254	6.43	Yes	Yes	2	6	9
174	R:R:F211	R:R:L259	7.31	Yes	Yes	2	6	6
175	R:R:F254	R:R:I214	6.28	Yes	No	0	9	7
176	R:R:L215	R:R:L251	4.15	No	No	0	5	8
177	R:R:I247	R:R:Y218	4.84	No	No	0	8	9
178	R:R:L220	R:R:R223	4.86	No	No	0	4	3
179	R:R:I247	R:R:M221	4.37	No	No	0	8	8
180	R:R:L225	R:R:V244	4.47	No	No	0	8	6
181	R:R:L226	R:R:V244	13.41	No	No	0	3	6
182	R:R:P228	R:R:P237	3.9	No	No	0	6	3
183	R:R:K240	R:R:P237	5.02	No	No	0	6	3
184	R:R:V250	R:R:Y306	5.05	No	Yes	0	8	9
185	R:R:L301	R:R:V253	5.96	No	No	0	7	7
186	R:R:L305	R:R:V253	4.47	Yes	No	0	8	7
187	R:R:F254	R:R:F258	8.57	Yes	No	2	9	9
188	R:R:C257	R:R:N298	9.45	No	No	0	8	9
189	R:R:F258	R:R:N298	14.5	No	No	0	9	9
190	R:R:F261	R:R:H262	12.44	No	Yes	0	7	8
191	R:R:F261	R:R:Y288	8.25	No	Yes	0	7	5
192	R:R:A295	R:R:F261	8.32	No	No	0	8	7
193	R:R:T264	R:R:T291	6.28	No	No	0	5	7
194	R:R:R265	R:R:Y269	18.52	No	Yes	0	6	5
195	R:R:R265	R:R:Y288	10.29	No	Yes	0	6	5
196	R:R:R272	R:R:Y268	21.61	Yes	Yes	1	3	4
197	R:R:I284	R:R:Y268	8.46	No	Yes	0	5	4
198	R:R:N285	R:R:Y268	9.3	No	Yes	1	3	4
199	R:R:Y268	R:R:Y288	5.96	Yes	Yes	0	4	5
200	R:R:F271	R:R:L276	6.09	Yes	No	0	3	1
201	R:R:F271	R:R:I284	6.28	Yes	No	0	3	5
202	R:R:K289	R:R:N285	12.59	Yes	No	1	5	3
203	R:R:R292	R:R:Y288	15.43	Yes	Yes	0	6	5
204	R:R:K289	R:R:R292	8.66	Yes	Yes	1	5	6
205	R:R:N298	R:R:N302	8.17	No	Yes	0	9	9
206	R:R:F307	R:R:P303	4.33	Yes	No	0	7	9
207	R:R:P293	R:R:S39	3.56	No	No	0	5	5
208	L:L:?1	R:R:H184	3.55	Yes	No	0	0	4
209	R:R:P210	R:R:V209	3.53	No	No	0	9	5
210	R:R:C300	R:R:V43	3.42	No	No	0	8	7
211	R:R:C217	R:R:V129	3.42	No	No	0	8	6
212	R:R:G204	R:R:L203	3.42	No	No	0	5	5
213	R:R:F73	R:R:H74	3.39	Yes	Yes	0	6	9
214	R:R:A176	R:R:V181	3.39	No	No	0	2	4
215	R:R:C106	R:R:T174	3.38	No	No	0	9	5
216	R:R:L122	R:R:P210	3.28	No	No	0	6	9
217	R:R:L259	R:R:P260	3.28	Yes	No	0	6	9
218	R:R:A222	R:R:I247	3.25	No	No	0	5	8
219	R:R:C132	R:R:M221	3.24	No	No	0	8	8
220	R:R:C300	R:R:L46	3.17	No	Yes	0	8	6
221	R:R:T115	R:R:V161	3.17	No	No	0	5	7
222	R:R:T125	R:R:V213	3.17	No	No	0	7	7
223	R:R:C132	R:R:L136	3.17	No	No	0	8	7
224	R:R:C164	R:R:L160	3.17	No	No	0	5	4
225	R:R:A83	R:R:L48	3.15	No	No	0	6	6
226	R:R:A76	R:R:L55	3.15	No	No	0	9	7
227	R:R:K107	R:R:V172	3.04	No	No	0	6	5
228	R:R:L35	R:R:V290	2.98	No	No	0	6	4
229	R:R:L46	R:R:V42	2.98	Yes	No	0	6	5
230	R:R:L46	R:R:V45	2.98	Yes	No	0	6	5
231	R:R:L225	R:R:V135	2.98	No	No	0	8	8
232	R:R:L205	R:R:V201	2.98	No	No	0	4	3
233	R:R:L220	R:R:V216	2.98	No	No	0	4	4
234	R:R:L305	R:R:V249	2.98	Yes	No	0	8	4
235	R:R:L305	R:R:V250	2.98	Yes	No	0	8	8
236	R:R:L259	R:R:V263	2.98	Yes	No	0	6	6
237	R:R:L162	R:R:T115	2.95	No	No	0	3	5
238	R:R:F101	R:R:P100	2.89	Yes	No	0	7	3
239	R:R:C25	R:R:F27	2.79	No	Yes	0	9	2
240	R:R:H184	R:R:S175	2.79	No	No	0	4	2
241	R:R:P37	R:R:Y93	2.78	No	Yes	0	5	6
242	R:R:A54	R:R:F307	2.77	No	Yes	0	9	7
243	R:R:A255	R:R:F211	2.77	No	Yes	0	5	6
244	R:R:R137	R:R:S141	2.64	No	Yes	0	7	5
245	R:R:R223	R:R:V219	2.62	No	No	0	3	4
246	R:R:T291	R:R:Y288	2.5	No	Yes	0	7	5
247	R:R:F211	R:R:L215	2.44	Yes	No	0	6	5
248	R:R:F271	R:R:L267	2.44	Yes	No	0	3	4
249	R:R:F307	R:R:L308	2.44	Yes	No	0	7	7
250	R:R:F27	R:R:N282	2.42	Yes	No	0	2	3
251	R:R:G178	R:R:G179	2.11	No	No	0	3	4
252	R:R:R148	R:R:Y149	2.06	No	No	0	4	3
253	R:R:C44	R:R:G41	1.96	No	No	0	7	5
254	R:R:A83	R:R:G47	1.95	No	No	0	6	8
255	R:R:A154	R:R:G155	1.95	No	No	0	7	3
256	R:R:A208	R:R:G204	1.95	No	No	0	5	5
257	R:R:A166	R:R:P167	1.87	No	No	0	4	8
258	R:R:A188	R:R:P189	1.87	No	No	0	5	3
259	R:R:G134	R:R:S141	1.86	No	Yes	0	8	5
260	R:R:P293	R:R:S296	1.78	No	Yes	0	5	7
261	R:R:P37	R:R:V90	1.77	No	No	0	5	7
262	R:R:C49	R:R:V45	1.71	No	No	0	4	5
263	R:R:G47	R:R:L46	1.71	No	Yes	0	8	6
264	R:R:A188	R:R:S187	1.71	No	No	0	5	5
265	R:R:A188	R:R:T173	1.68	No	No	0	5	4
266	R:R:A287	R:R:T264	1.68	No	No	0	5	5
267	R:R:K227	R:R:P228	1.67	No	No	0	3	6
268	R:R:L50	R:R:P303	1.64	No	No	0	8	9
269	R:R:S102	R:R:V104	1.62	No	No	0	7	2
270	R:R:S277	R:R:T280	1.6	No	No	0	6	2
271	R:R:T246	R:R:V250	1.59	No	No	0	7	8
272	R:R:A80	R:R:L55	1.58	No	No	0	7	7
273	R:R:I57	R:R:V53	1.54	No	No	0	7	6
274	R:R:M202	R:R:V201	1.52	No	No	0	6	3
275	R:R:L35	R:R:S39	1.5	No	No	0	6	5
276	R:R:L225	R:R:S243	1.5	No	No	0	8	7
277	R:R:K242	R:R:T246	1.5	No	No	0	7	7
278	R:R:L274	R:R:S270	1.5	No	No	0	1	5
279	R:R:L50	R:R:V304	1.49	No	No	0	8	7
280	R:R:L301	R:R:V304	1.49	No	No	0	7	7
281	R:R:L305	R:R:V304	1.49	Yes	No	0	8	7
282	R:R:P237	R:R:R241	1.44	No	No	0	3	4
283	R:R:I57	R:R:L62	1.43	No	No	0	7	5
284	R:R:H279	R:R:S277	1.39	No	No	0	3	6
285	R:R:N28	R:R:N282	1.36	No	No	0	5	3
286	R:R:R194	R:R:S193	1.32	Yes	No	0	4	1
287	R:R:R152	R:R:V153	1.31	No	No	0	3	5
288	R:R:R245	R:R:V249	1.31	No	No	0	5	4
289	R:R:F271	R:R:T280	1.3	Yes	No	0	3	2
290	R:R:F111	R:R:L108	1.22	No	No	0	6	5
291	R:R:I57	R:R:Y56	1.21	No	No	0	7	4
292	R:R:D275	R:R:R24	1.19	No	No	0	1	2
293	R:R:R238	R:R:R241	1.07	No	No	0	3	4
294	R:R:F101	R:R:Y91	1.03	Yes	No	0	7	5
295	R:R:R143	R:R:W144	1	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	11.1627	11	1	0
2	R:R:F27	8.38571	7	1	2
3	R:R:E29	6.5125	4	1	2
4	R:R:K32	6.1825	4	1	3
5	R:R:Y40	4.715	4	1	8
6	R:R:L46	2.71	4	0	6
7	R:R:Y71	6.314	5	0	7
8	R:R:F73	4.59	5	0	6
9	R:R:H74	6.802	5	3	9
10	R:R:D79	6.28	4	0	9
11	R:R:Y82	7.81667	6	0	7
12	R:R:Y92	7.695	4	1	6
13	R:R:Y93	6.076	5	1	6
14	R:R:H98	8.4325	4	0	5
15	R:R:W99	8.285	6	1	8
16	R:R:F101	4.6475	4	1	7
17	R:R:R110	10.5375	4	0	6
18	R:R:L124	6.1275	4	2	8
19	R:R:H130	7.7475	4	0	8
20	R:R:S141	4.03	4	5	5
21	R:R:R146	7.5975	4	5	7
22	R:R:W158	7	4	3	9
23	R:R:F171	7.35	5	1	5
24	R:R:C183	8.82	4	1	9
25	R:R:D185	10.435	4	1	4
26	R:R:T186	9.1075	4	1	3
27	R:R:R194	5.6	4	1	4
28	R:R:F195	6.378	5	1	2
29	R:R:Y198	9.62	4	0	4
30	R:R:F211	5.076	5	2	6
31	R:R:F254	5.984	5	2	9
32	R:R:L259	4.305	4	2	6
33	R:R:H262	13.6175	4	0	8
34	R:R:Y268	9.665	6	1	4
35	R:R:Y269	9.8875	4	1	5
36	R:R:F271	4.0275	4	0	3
37	R:R:R272	13.71	4	1	3
38	R:R:Y288	8.486	5	0	5
39	R:R:K289	8.104	5	1	5
40	R:R:R292	7.915	6	1	6
41	R:R:S296	5.0975	4	0	7
42	R:R:N302	7.1525	4	2	9
43	R:R:L305	2.98	4	0	8
44	R:R:Y306	5.48	4	2	9
45	R:R:F307	6.078	5	4	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:H184	16.192	3.55	Yes	No	0	0	4
2	L:L:?1	R:R:Y268	14.1	6.47	Yes	Yes	1	0	4
3	L:L:?1	R:R:R292	29.9606	9.38	Yes	Yes	1	0	6
4	R:R:R292	R:R:Y93	13.7997	5.14	Yes	Yes	1	6	6
5	R:R:R292	R:R:Y40	31.2966	4.12	Yes	Yes	1	6	8
6	R:R:L86	R:R:Y40	27.7392	4.69	No	Yes	0	8	8
7	R:R:S296	R:R:Y40	34.4708	5.09	Yes	Yes	0	7	8
8	R:R:S296	R:R:V43	12.8573	9.7	Yes	No	0	7	7
9	L:L:?1	R:R:D185	13.7169	7.49	Yes	Yes	1	0	4
10	R:R:F113	R:R:Y114	16.57	7.22	No	No	0	6	5
11	R:R:F113	R:R:Y82	38.3751	15.47	No	Yes	0	6	7
12	R:R:S299	R:R:Y82	92.3001	8.9	No	Yes	0	8	7
13	R:R:D79	R:R:S299	91.3577	5.89	Yes	No	0	9	8
14	R:R:L86	R:R:Y82	27.8014	8.21	No	Yes	0	8	7
15	R:R:S296	R:R:Y82	34.6883	3.82	Yes	Yes	0	7	7
16	R:R:D79	R:R:N51	22.6284	6.73	Yes	No	0	9	9
17	R:R:N51	R:R:P303	20.6659	6.52	No	No	0	9	9
18	R:R:D79	R:R:N302	75.1657	8.08	Yes	Yes	0	9	9
19	R:R:L124	R:R:N302	70.873	8.24	Yes	Yes	2	8	9
20	R:R:L124	R:R:Y306	100	5.86	Yes	Yes	2	8	9
21	R:R:I127	R:R:Y306	79.1995	4.84	No	Yes	2	9	9
22	R:R:I127	R:R:Y71	84.564	3.63	No	Yes	0	9	7
23	R:R:A150	R:R:Y71	58.9633	5.34	No	Yes	0	8	7
24	R:R:A150	R:R:T70	57.327	5.03	No	No	0	8	7
25	R:R:T70	R:R:W65	55.6804	7.28	No	No	0	7	6
26	R:R:F73	R:R:W65	38.6288	7.02	Yes	No	0	6	6
27	R:R:Y268	R:R:Y288	25.7923	5.96	Yes	Yes	0	4	5
28	R:R:F261	R:R:Y288	48.2343	8.25	No	Yes	0	7	5
29	R:R:F261	R:R:H262	47.6232	12.44	No	Yes	0	7	8
30	R:R:F207	R:R:H262	55.059	30.55	No	Yes	0	8	8
31	R:R:F207	R:R:F211	52.2007	6.43	No	Yes	2	8	6
32	R:R:F211	R:R:F254	53.4952	6.43	Yes	Yes	2	6	9
33	R:R:F254	R:R:L124	38.6858	4.87	Yes	Yes	2	9	8
34	R:R:R292	R:R:Y288	26.134	15.43	Yes	Yes	0	6	5
35	R:R:T69	R:R:W65	17.3312	4.85	No	No	0	7	6
36	R:R:N66	R:R:T69	15.4464	4.39	No	No	0	7	7
37	R:R:N66	R:R:T64	13.5512	4.39	No	No	0	7	6
38	R:R:L62	R:R:T64	11.6456	5.9	No	No	0	5	6
39	R:R:F307	R:R:P303	11.9045	4.33	Yes	No	0	7	9
40	R:R:H130	R:R:Y71	24.0524	4.36	Yes	Yes	0	8	7
41	R:R:F73	R:R:H74	28.4227	3.39	Yes	Yes	0	6	9
42	R:R:H74	R:R:W158	17.238	6.35	Yes	Yes	3	9	9
43	R:R:C119	R:R:W158	13.5149	5.22	No	Yes	3	7	9
44	R:R:D97	R:R:Y92	10.553	8.05	No	Yes	0	4	6
45	R:R:W99	R:R:Y92	32.2494	7.72	Yes	Yes	1	8	6
46	R:R:Y92	R:R:Y93	34.6106	6.95	Yes	Yes	1	6	6
47	R:R:C183	R:R:R110	16.4509	5.57	Yes	Yes	0	9	6
48	R:R:C183	R:R:W99	11.8734	14.37	Yes	Yes	1	9	8
49	R:R:L89	R:R:R110	13.6185	7.29	No	Yes	0	6	6
50	R:R:L89	R:R:V109	10.4029	4.47	No	No	0	6	5
51	R:R:F101	R:R:W99	35.8792	11.02	Yes	Yes	1	7	8
52	R:R:F101	R:R:P100	28.9095	2.89	Yes	No	0	7	3
53	R:R:H98	R:R:P100	25.3314	18.3	Yes	No	0	5	3
54	R:R:H98	R:R:R180	10.9155	6.77	Yes	No	0	5	2
55	R:R:L105	R:R:W99	10.7601	5.69	No	Yes	1	6	8
56	R:R:C119	R:R:V161	11.6456	5.12	No	No	0	7	7
57	L:L:?1	R:R:T186	16.249	12.2	Yes	Yes	1	0	3
58	R:R:R265	R:R:Y269	11.278	18.52	No	Yes	0	6	5
59	R:R:F195	R:R:T186	13.722	3.89	Yes	Yes	1	2	3
60	R:R:F171	R:R:F195	11.9925	12.86	Yes	Yes	1	5	2
61	R:R:F171	R:R:Y198	12.9039	7.22	Yes	Yes	0	5	4
62	R:R:V168	R:R:Y198	10.553	3.79	No	Yes	0	4	4
63	R:R:Q165	R:R:V168	10.6307	4.3	No	No	0	7	4
64	R:R:H262	R:R:Y118	14.4056	7.62	Yes	No	0	8	7
65	R:R:Q165	R:R:Y118	11.832	9.02	No	No	0	7	7
66	R:R:F254	R:R:I214	21.7947	6.28	Yes	No	0	9	7
67	R:R:R131	R:R:Y306	14.8664	6.17	No	Yes	2	9	9
68	R:R:I214	R:R:S128	15.7104	6.19	No	No	0	7	9
69	R:R:S128	R:R:Y218	15.0528	6.36	No	No	0	9	9
70	R:R:H130	R:R:R146	18.7034	12.41	Yes	Yes	0	8	7
71	R:R:I247	R:R:Y218	29.7742	4.84	No	No	0	8	9
72	R:R:I247	R:R:M221	26.5793	4.37	No	No	0	8	8
73	R:R:C132	R:R:M221	16.3059	3.24	No	No	0	8	8
74	R:R:C132	R:R:L136	10.9621	3.17	No	No	0	8	7
75	R:R:R146	R:R:S141	11.3194	7.91	Yes	Yes	5	7	5
76	R:R:V250	R:R:Y306	17.1758	5.05	No	Yes	0	8	9
77	R:R:L50	R:R:P303	11.2572	1.64	No	No	0	8	9
78	R:R:L50	R:R:V304	10.1284	1.49	No	No	0	8	7
79	R:R:L305	R:R:V250	12.0909	2.98	Yes	No	0	8	8
80	R:R:I284	R:R:Y268	16.9584	8.46	No	Yes	0	5	4
81	R:R:F271	R:R:I284	14.5661	6.28	Yes	No	0	3	5
82	R:R:C300	R:R:V43	11.4696	3.42	No	No	0	8	7
83	R:R:C300	R:R:L46	10.0715	3.17	No	Yes	0	8	6
84	R:R:Y40	R:R:Y93	29.7225	4.96	Yes	Yes	1	8	6
85	R:R:R131	R:R:Y218	20.1999	8.23	No	No	0	9	9
86	R:R:F113	R:R:L89	22.9184	3.65	No	No	0	6	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:Y23	32.33	1	Yes	No	0	6	0	1
L:L:?1	R:R:F27	20.83	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:E29	8.04	1	Yes	Yes	0	2	0	1
L:L:?1	R:R:K32	3.89	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:D185	7.49	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:T186	12.2	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:Y268	6.47	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:R272	10.05	1	Yes	Yes	0	3	0	1
L:L:?1	R:R:K289	8.56	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R292	9.38	1	Yes	Yes	0	6	0	1
R:R:E29	R:R:F27	4.66	1	Yes	Yes	2	2	1	1
R:R:F27	R:R:Y268	6.19	1	Yes	Yes	2	4	1	1
R:R:F27	R:R:L281	7.31	1	Yes	No	2	1	1	2
R:R:F27	R:R:N285	14.5	1	Yes	No	2	3	1	2
R:R:E29	R:R:K32	9.45	1	Yes	Yes	2	3	1	1
R:R:D97	R:R:E29	3.9	0	No	Yes	4	2	2	1
R:R:F31	R:R:K289	4.96	0	No	Yes	5	5	2	1
R:R:K32	R:R:L36	5.64	1	Yes	No	3	5	1	2
R:R:K289	R:R:K32	5.75	1	Yes	Yes	5	3	1	1
R:R:L36	R:R:Y93	10.55	0	No	Yes	5	6	2	2
R:R:Y40	R:R:Y93	4.96	1	Yes	Yes	8	6	2	2
R:R:R292	R:R:Y40	4.12	1	Yes	Yes	6	8	1	2
R:R:R292	R:R:Y93	5.14	1	Yes	Yes	6	6	1	2
R:R:D185	R:R:R110	21.44	1	Yes	Yes	4	6	1	2
R:R:D185	R:R:Y114	8.05	1	Yes	No	4	5	1	2
R:R:H184	R:R:T182	4.11	0	No	No	4	4	1	2
R:R:D185	R:R:R292	4.76	1	Yes	Yes	4	6	1	1
R:R:F195	R:R:T186	3.89	1	Yes	Yes	2	3	2	1
R:R:T186	R:R:Y269	9.99	1	Yes	Yes	3	5	1	2
R:R:R272	R:R:T186	10.35	1	Yes	Yes	3	3	1	1
R:R:F192	R:R:R272	12.83	0	No	Yes	2	3	2	1
R:R:F195	R:R:Y269	7.22	1	Yes	Yes	2	5	2	2
R:R:R272	R:R:Y268	21.61	1	Yes	Yes	3	4	1	1
R:R:I284	R:R:Y268	8.46	0	No	Yes	5	4	2	1
R:R:N285	R:R:Y268	9.3	1	No	Yes	3	4	2	1
R:R:Y268	R:R:Y288	5.96	1	Yes	Yes	4	5	1	2
R:R:K289	R:R:N285	12.59	1	Yes	No	5	3	1	2
R:R:R292	R:R:Y288	15.43	1	Yes	Yes	6	5	1	2
R:R:K289	R:R:R292	8.66	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:H184	3.55	1	Yes	No	0	4	0	1
R:R:C25	R:R:F27	2.79	0	No	Yes	9	2	2	1
R:R:H184	R:R:S175	2.79	0	No	No	4	2	1	2
R:R:F27	R:R:N282	2.42	1	Yes	No	2	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K0X_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.63
Number of Linked Nodes	257
Number of Links	295
Number of Hubs	45
Number of Links mediated by Hubs	161
Number of Communities	5
Number of Nodes involved in Communities	49
Number of Links involved in Communities	70

Path Summary
Number Of Nodes in MetaPath	87
Number Of Links MetaPath	86
Number of Shortest Paths	48841
Length Of Smallest Path	3
Average Path Length	13.1339
Length of Longest Path	30
Minimum Path Strength	1.255
Average Path Strength	7.12841
Maximum Path Strength	26.58
Minimum Path Correlation	0.7
Average Path Correlation	0.916607
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	47.8326
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.8404
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • synapse • cell junction • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled pyrimidinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled UTP receptor activity • A1 adenosine receptor binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • regulation of localization • regulation of body fluid levels • multicellular organismal process • secretion by tissue • regulation of transport • transport • secretion • regulation of mucus secretion • positive regulation of biological process • establishment of localization • mucus secretion • regulation of secretion • localization • body fluid secretion • positive regulation of secretion • positive regulation of transport • positive regulation of mucus secretion • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of biological quality • cellular homeostasis • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • cellular response to ATP • response to organophosphorus • response to ATP • response to purine-containing compound • regulation of tube diameter • system process • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic nucleotide receptor signaling pathway • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ATP
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ATP
Name	ATP
Synonyms	Adenosine triphosphate disodium trihydrate
Identifier
Formula	C10 H16 N5 O13 P3
Molecular Weight	507.181
SMILES
PubChem	5957
Formal Charge	0
Total Atoms	47
Total Chiral Atoms	6
Total Bonds	49
Total Aromatic Bonds	10


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41231
Sequence	>9K0X_nogp_Chain_R L G Y R C R F N E D F K Y V L L P V S Y G V V C V G L C L N A V A L Y I F L C R L K T W N A S T T Y M F H L A V S D A L Y A A S L P L L V Y Y Y A R G D H W P F S T V L C K L V R F L F Y T N L Y C S I L F L T C I S V H R C L G V L R P L R S L R W G R A R Y A R R V A G A V W V L V L A C Q A P V L Y F V T T S A R G G R V T C H D T S A P E L F S R F V A Y S S V M L G L L F A V P F A V I L V C Y V L M A R R L L K P P R A K R K S V R T I A V V L A V F A L C F L P F H V T R T L Y Y S F R S L D L S C H T L N A I N M A Y K V T R P L A S A N S C L P V L Y F L L N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K20	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-	chim(NtGi1-Go)/β1/γ2	2.65	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K20 (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-		2.65	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0X	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.83	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0X (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-		2.83	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K25	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.31	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K25 (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	-	-		3.31	2025-06-11	doi.org/10.1038/s41421-025-00797-x

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