psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T15	R:R:W16	3.64	No	Yes	0	6	7
2	R:R:D185	R:R:T15	4.34	No	No	0	4	6
3	R:R:T15	R:R:Y268	8.74	No	Yes	0	6	4
4	R:R:D17	R:R:W16	4.47	No	Yes	0	7	7
5	R:R:F192	R:R:W16	17.04	No	Yes	0	2	7
6	R:R:G18	R:R:L21	5.13	No	Yes	0	5	3
7	R:R:L21	R:R:R272	3.64	Yes	No	0	3	3
8	R:R:R26	R:R:Y23	14.4	No	No	0	2	6
9	R:R:C25	R:R:C278	7.28	No	No	0	9	7
10	R:R:N28	R:R:Y33	9.3	No	No	0	5	5
11	R:R:E29	R:R:K32	8.1	No	No	0	2	3
12	R:R:K32	R:R:M286	14.4	No	Yes	0	3	1
13	R:R:Y33	R:R:Y93	10.92	No	No	0	5	6
14	R:R:M286	R:R:Y33	3.59	Yes	No	0	1	5
15	R:R:L35	R:R:V38	5.96	No	No	0	6	5
16	R:R:L36	R:R:Y93	12.89	No	No	0	5	6
17	R:R:P37	R:R:Y93	6.95	No	No	0	5	6
18	R:R:A94	R:R:P37	3.74	No	No	0	5	5
19	R:R:Y40	R:R:Y82	3.97	No	Yes	0	8	7
20	R:R:L89	R:R:Y40	7.03	No	No	0	6	8
21	R:R:C44	R:R:L86	6.35	Yes	No	0	7	8
22	R:R:G47	R:R:N51	5.09	No	Yes	0	8	9
23	R:R:D79	R:R:N51	5.39	No	Yes	0	9	9
24	R:R:A80	R:R:N51	4.69	No	Yes	0	7	9
25	R:R:N51	R:R:P303	6.52	Yes	No	0	9	9
26	R:R:F73	R:R:L55	3.65	Yes	No	0	6	7
27	R:R:R61	R:R:Y56	11.32	No	No	0	4	4
28	R:R:F58	R:R:L62	9.74	Yes	No	2	7	5
29	R:R:F58	R:R:W65	35.08	Yes	Yes	2	7	6
30	R:R:F58	R:R:T69	11.67	Yes	No	0	7	7
31	R:R:F58	R:R:F73	16.08	Yes	Yes	2	7	6
32	R:R:F307	R:R:F58	8.57	Yes	Yes	0	7	7
33	R:R:L62	R:R:W65	5.69	No	Yes	2	5	6
34	R:R:T70	R:R:W65	4.85	No	Yes	0	7	6
35	R:R:F73	R:R:W65	11.02	Yes	Yes	2	6	6
36	R:R:N66	R:R:T69	8.77	No	No	0	7	7
37	R:R:A67	R:R:H130	7.32	No	No	0	7	8
38	R:R:H130	R:R:S68	6.97	No	No	0	8	8
39	R:R:A150	R:R:T70	5.03	No	No	0	8	7
40	R:R:I127	R:R:Y71	7.25	No	Yes	0	9	7
41	R:R:A150	R:R:Y71	4	No	Yes	0	8	7
42	R:R:V153	R:R:Y71	6.31	No	Yes	0	5	7
43	R:R:M72	R:R:Y306	7.18	No	Yes	0	8	9
44	R:R:F307	R:R:M72	7.46	Yes	No	0	7	8
45	R:R:F123	R:R:H74	5.66	Yes	Yes	3	8	9
46	R:R:A154	R:R:H74	5.85	No	Yes	0	7	9
47	R:R:H74	R:R:W158	11.64	Yes	Yes	3	9	9
48	R:R:F123	R:R:L75	8.53	Yes	No	0	8	9
49	R:R:L75	R:R:N302	5.49	No	No	0	9	9
50	R:R:S78	R:R:W158	4.94	No	Yes	0	8	9
51	R:R:D79	R:R:N116	5.39	No	No	1	9	8
52	R:R:D79	R:R:S299	8.83	No	No	1	9	8
53	R:R:L86	R:R:Y82	19.93	No	Yes	0	8	7
54	R:R:F113	R:R:Y82	12.38	Yes	Yes	1	6	7
55	R:R:N116	R:R:Y82	17.44	No	Yes	1	8	7
56	R:R:S296	R:R:Y82	6.36	No	Yes	1	7	7
57	R:R:L105	R:R:L88	4.15	No	No	0	6	7
58	R:R:L88	R:R:V109	4.47	No	No	0	7	5
59	R:R:L89	R:R:V109	4.47	No	No	0	6	5
60	R:R:R95	R:R:Y91	4.12	No	No	0	5	5
61	R:R:H98	R:R:Y92	11.98	No	Yes	4	5	6
62	R:R:P100	R:R:Y92	8.34	No	Yes	0	3	6
63	R:R:T182	R:R:Y92	3.75	Yes	Yes	4	4	6
64	R:R:C183	R:R:Y92	4.03	No	Yes	0	9	6
65	R:R:D97	R:R:H98	23.95	No	No	0	4	5
66	R:R:H98	R:R:T182	5.48	No	Yes	4	5	4
67	R:R:T182	R:R:W99	3.64	Yes	No	0	4	8
68	R:R:F101	R:R:L105	3.65	No	No	0	7	6
69	R:R:T103	R:R:T174	6.28	No	No	0	3	5
70	R:R:C106	R:R:C183	7.28	No	No	0	9	9
71	R:R:R110	R:R:R292	4.26	No	Yes	0	6	6
72	R:R:F111	R:R:L169	3.65	Yes	No	0	6	5
73	R:R:F113	R:R:Y114	5.16	Yes	Yes	1	6	5
74	R:R:F113	R:R:R292	9.62	Yes	Yes	0	6	6
75	R:R:F113	R:R:S296	3.96	Yes	No	1	6	7
76	R:R:Q165	R:R:Y114	4.51	Yes	Yes	1	7	5
77	R:R:V168	R:R:Y114	10.09	No	Yes	1	4	5
78	R:R:R265	R:R:Y114	10.29	Yes	Yes	1	6	5
79	R:R:N116	R:R:S299	7.45	No	No	1	8	8
80	R:R:F258	R:R:L117	9.74	Yes	No	0	9	7
81	R:R:F261	R:R:L117	3.65	Yes	No	0	7	7
82	R:R:Q165	R:R:Y118	9.02	Yes	Yes	1	7	7
83	R:R:M202	R:R:Y118	8.38	Yes	Yes	1	6	7
84	R:R:L206	R:R:Y118	7.03	No	Yes	1	6	7
85	R:R:H262	R:R:Y118	7.62	Yes	Yes	1	8	7
86	R:R:C119	R:R:F123	5.59	No	Yes	3	7	8
87	R:R:C119	R:R:W158	7.84	No	Yes	3	7	9
88	R:R:F258	R:R:S120	3.96	Yes	No	0	9	9
89	R:R:F254	R:R:I121	6.28	Yes	No	1	9	8
90	R:R:F258	R:R:I121	12.56	Yes	No	1	9	8
91	R:R:L122	R:R:V157	5.96	No	No	0	6	7
92	R:R:F123	R:R:V157	5.24	Yes	No	0	8	7
93	R:R:F123	R:R:W158	6.01	Yes	Yes	3	8	9
94	R:R:F254	R:R:L124	8.53	Yes	No	1	9	8
95	R:R:L124	R:R:N302	4.12	No	No	1	8	9
96	R:R:L124	R:R:Y306	8.21	No	Yes	1	8	9
97	R:R:P210	R:R:T125	5.25	No	No	0	9	7
98	R:R:I127	R:R:R131	3.76	No	No	0	9	9
99	R:R:I127	R:R:Y306	7.25	No	Yes	0	9	9
100	R:R:I214	R:R:S128	7.74	Yes	No	1	7	9
101	R:R:S128	R:R:Y218	10.17	No	Yes	1	9	9
102	R:R:H130	R:R:R146	13.54	No	Yes	0	8	7
103	R:R:R131	R:R:Y218	5.14	No	Yes	0	9	9
104	R:R:M221	R:R:R131	6.2	No	No	0	8	9
105	R:R:C132	R:R:C217	7.28	No	No	0	8	8
106	R:R:C132	R:R:M221	6.48	No	No	0	8	8
107	R:R:L133	R:R:R146	4.86	No	Yes	0	5	7
108	R:R:G134	R:R:R146	4.5	No	Yes	0	8	7
109	R:R:M221	R:R:V135	7.61	No	No	0	8	8
110	R:R:L136	R:R:R224	8.5	No	No	0	7	5
111	R:R:R137	R:R:R140	12.79	Yes	No	5	7	4
112	R:R:R146	R:R:S141	6.59	Yes	No	0	7	5
113	R:R:R148	R:R:R152	5.33	No	No	0	4	3
114	R:R:R152	R:R:Y149	10.29	No	No	0	3	3
115	R:R:Q165	R:R:V168	4.3	Yes	No	1	7	4
116	R:R:P167	R:R:Y198	11.13	No	No	0	8	4
117	R:R:V168	R:R:Y198	5.05	No	No	0	4	4
118	R:R:F171	R:R:Y170	8.25	Yes	No	0	5	4
119	R:R:F171	R:R:S187	5.28	Yes	No	1	5	5
120	R:R:F171	R:R:F195	8.57	Yes	Yes	1	5	2
121	R:R:D185	R:R:H184	5.04	No	No	0	4	4
122	R:R:H184	R:R:T186	12.32	No	No	0	4	3
123	R:R:F192	R:R:T186	6.49	No	No	0	2	3
124	R:R:F195	R:R:T186	5.19	Yes	No	0	2	3
125	R:R:F195	R:R:S187	3.96	Yes	No	1	2	5
126	R:R:E190	R:R:L191	3.98	No	No	0	1	3
127	R:R:F192	R:R:V196	3.93	No	No	0	2	3
128	R:R:F195	R:R:Y269	11.35	Yes	Yes	1	2	5
129	R:R:S270	R:R:V196	8.08	No	No	0	5	3
130	R:R:M202	R:R:Y198	8.38	Yes	No	0	6	4
131	R:R:R265	R:R:S199	13.18	Yes	No	1	6	5
132	R:R:S199	R:R:Y269	5.09	No	Yes	1	5	5
133	R:R:L206	R:R:M202	4.24	No	Yes	1	6	6
134	R:R:F207	R:R:L203	4.87	Yes	Yes	1	8	5
135	R:R:H262	R:R:L203	5.14	Yes	Yes	1	8	5
136	R:R:F207	R:R:F211	6.43	Yes	Yes	1	8	6
137	R:R:F207	R:R:L259	4.87	Yes	No	1	8	6
138	R:R:F207	R:R:H262	22.63	Yes	Yes	1	8	8
139	R:R:F211	R:R:L215	9.74	Yes	No	0	6	5
140	R:R:F211	R:R:F254	6.43	Yes	Yes	1	6	9
141	R:R:F211	R:R:L259	3.65	Yes	No	1	6	6
142	R:R:I214	R:R:Y218	3.63	Yes	Yes	1	7	9
143	R:R:I214	R:R:L251	4.28	Yes	No	1	7	8
144	R:R:F254	R:R:I214	7.54	Yes	Yes	1	9	7
145	R:R:L215	R:R:L251	4.15	No	No	0	5	8
146	R:R:I247	R:R:Y218	9.67	No	Yes	0	8	9
147	R:R:V250	R:R:Y218	6.31	No	Yes	0	8	9
148	R:R:L251	R:R:Y218	5.86	No	Yes	1	8	9
149	R:R:L225	R:R:S243	4.5	No	No	0	8	7
150	R:R:K240	R:R:R241	9.9	No	No	0	6	4
151	R:R:K242	R:R:R245	7.43	No	No	0	7	5
152	R:R:V250	R:R:Y306	5.05	No	Yes	0	8	9
153	R:R:L301	R:R:V253	4.47	No	No	0	7	7
154	R:R:L305	R:R:V253	4.47	No	No	0	8	7
155	R:R:F254	R:R:F258	8.57	Yes	Yes	1	9	9
156	R:R:C257	R:R:N298	9.45	No	No	0	8	9
157	R:R:F258	R:R:N298	16.92	Yes	No	0	9	9
158	R:R:L259	R:R:P260	4.93	No	No	0	6	9
159	R:R:F261	R:R:H262	5.66	Yes	Yes	0	7	8
160	R:R:F261	R:R:R265	5.34	Yes	Yes	0	7	6
161	R:R:F261	R:R:Y288	4.13	Yes	Yes	0	7	5
162	R:R:F261	R:R:T291	5.19	Yes	No	0	7	7
163	R:R:A295	R:R:F261	4.16	No	Yes	0	8	7
164	R:R:T264	R:R:T291	4.71	No	No	0	5	7
165	R:R:R265	R:R:Y269	11.32	Yes	Yes	1	6	5
166	R:R:I284	R:R:L267	5.71	No	No	0	5	4
167	R:R:Y268	R:R:Y269	5.96	Yes	Yes	0	4	5
168	R:R:R272	R:R:Y268	7.2	No	Yes	0	3	4
169	R:R:I284	R:R:Y268	3.63	No	Yes	0	5	4
170	R:R:N285	R:R:Y268	4.65	No	Yes	0	3	4
171	R:R:Y268	R:R:Y288	5.96	Yes	Yes	0	4	5
172	R:R:L281	R:R:R272	4.86	Yes	No	0	1	3
173	R:R:L276	R:R:L281	4.15	No	Yes	0	1	1
174	R:R:S277	R:R:T280	6.4	No	No	0	6	2
175	R:R:M286	R:R:N282	4.21	Yes	No	0	1	3
176	R:R:K289	R:R:M286	5.76	No	Yes	0	5	1
177	R:R:K289	R:R:Y288	3.58	No	Yes	0	5	5
178	R:R:R292	R:R:Y288	8.23	Yes	Yes	0	6	5
179	R:R:N302	R:R:Y306	12.79	No	Yes	1	9	9
180	R:R:L308	R:R:V304	4.47	No	No	0	7	7
181	R:R:L305	R:R:Y306	5.86	No	Yes	0	8	9
182	R:R:P293	R:R:S39	3.56	No	No	0	5	5
183	R:R:P210	R:R:V209	3.53	No	No	0	9	5
184	R:R:L89	R:R:Y92	3.52	No	Yes	0	6	6
185	R:R:F111	R:R:Q165	3.51	Yes	Yes	0	6	7
186	R:R:C217	R:R:V129	3.42	No	No	0	8	6
187	R:R:L133	R:R:W144	3.42	No	No	0	5	4
188	R:R:G204	R:R:L203	3.42	No	Yes	0	5	5
189	R:R:I121	R:R:P210	3.39	No	No	0	8	9
190	R:R:C164	R:R:M202	3.24	No	Yes	0	5	6
191	R:R:C44	R:R:L48	3.17	Yes	No	0	7	6
192	R:R:T115	R:R:V161	3.17	No	No	0	5	7
193	R:R:T125	R:R:V213	3.17	No	No	0	7	7
194	R:R:A83	R:R:L48	3.15	No	No	0	6	6
195	R:R:T174	R:R:T182	3.14	No	Yes	0	5	4
196	R:R:I57	R:R:V53	3.07	No	No	0	7	6
197	R:R:M72	R:R:S68	3.07	No	No	0	8	8
198	R:R:K107	R:R:V172	3.04	No	No	0	6	5
199	R:R:L112	R:R:S85	3	No	No	0	5	7
200	R:R:L105	R:R:S102	3	No	No	0	6	7
201	R:R:L191	R:R:S187	3	No	No	0	3	5
202	R:R:L46	R:R:V42	2.98	No	No	0	6	5
203	R:R:L46	R:R:V45	2.98	No	No	0	6	5
204	R:R:L50	R:R:V304	2.98	No	No	0	8	7
205	R:R:L122	R:R:V161	2.98	No	No	0	6	7
206	R:R:L205	R:R:V201	2.98	No	No	0	4	3
207	R:R:L220	R:R:V216	2.98	No	No	0	4	4
208	R:R:L203	R:R:T266	2.95	Yes	No	0	5	5
209	R:R:L294	R:R:T291	2.95	No	No	0	7	7
210	R:R:C278	R:R:F27	2.79	No	No	0	7	2
211	R:R:A54	R:R:F307	2.77	No	Yes	0	9	7
212	R:R:L136	R:R:L220	2.77	No	No	0	7	4
213	R:R:A255	R:R:F211	2.77	No	Yes	0	5	6
214	R:R:P189	R:R:W16	2.7	No	Yes	0	3	7
215	R:R:C60	R:R:Y56	2.69	No	No	0	5	4
216	R:R:C126	R:R:Y71	2.69	No	Yes	0	6	7
217	R:R:A176	R:R:W99	2.59	No	No	0	2	8
218	R:R:F271	R:R:T266	2.59	No	No	0	3	5
219	R:R:F111	R:R:L112	2.44	Yes	No	0	6	5
220	R:R:F111	R:R:L162	2.44	Yes	No	0	6	3
221	R:R:L133	R:R:R137	2.43	No	Yes	0	5	7
222	R:R:L220	R:R:R223	2.43	No	No	0	4	3
223	R:R:F171	R:R:R194	2.14	Yes	No	0	5	4
224	R:R:C44	R:R:G41	1.96	Yes	No	0	7	5
225	R:R:C300	R:R:G47	1.96	No	No	0	8	8
226	R:R:A154	R:R:G155	1.95	No	No	0	7	3
227	R:R:A208	R:R:G204	1.95	No	No	0	5	5
228	R:R:C44	R:R:P87	1.88	Yes	No	0	7	9
229	R:R:A166	R:R:P167	1.87	No	No	0	4	8
230	R:R:A188	R:R:P189	1.87	No	No	0	5	3
231	R:R:G41	R:R:V90	1.84	No	No	0	5	7
232	R:R:A297	R:R:C257	1.81	No	No	0	6	8
233	R:R:G22	R:R:L21	1.71	No	Yes	0	4	3
234	R:R:C300	R:R:V43	1.71	No	No	0	8	7
235	R:R:G47	R:R:L46	1.71	No	No	0	8	6
236	R:R:A287	R:R:T264	1.68	No	No	0	5	5
237	R:R:L50	R:R:P303	1.64	No	No	0	8	9
238	R:R:L139	R:R:P138	1.64	No	No	0	5	7
239	R:R:V38	R:R:V42	1.6	No	No	0	5	5
240	R:R:C25	R:R:L21	1.59	No	Yes	0	9	3
241	R:R:C25	R:R:L281	1.59	No	Yes	0	9	1
242	R:R:C49	R:R:L50	1.59	No	No	0	4	8
243	R:R:T103	R:R:V104	1.59	No	No	0	3	2
244	R:R:C164	R:R:L160	1.59	No	No	0	5	4
245	R:R:T246	R:R:V250	1.59	No	No	0	7	8
246	R:R:C257	R:R:L256	1.59	No	No	0	8	6
247	R:R:T264	R:R:V263	1.59	No	No	0	5	6
248	R:R:A84	R:R:L48	1.58	No	No	0	5	6
249	R:R:T103	R:R:T173	1.57	No	No	0	3	4
250	R:R:M202	R:R:V201	1.52	Yes	No	0	6	3
251	R:R:M286	R:R:V290	1.52	Yes	No	0	1	4
252	R:R:G96	R:R:R95	1.5	No	No	0	3	5
253	R:R:K107	R:R:T173	1.5	No	No	0	6	4
254	R:R:L274	R:R:S273	1.5	No	No	0	1	1
255	R:R:L81	R:R:V77	1.49	No	No	0	7	6
256	R:R:L225	R:R:V135	1.49	No	No	0	8	8
257	R:R:L225	R:R:V244	1.49	No	No	0	8	6
258	R:R:L226	R:R:V244	1.49	No	No	0	3	6
259	R:R:L305	R:R:V249	1.49	No	No	0	8	4
260	R:R:L62	R:R:T64	1.47	No	No	0	5	6
261	R:R:L281	R:R:T280	1.47	Yes	No	0	1	2
262	R:R:D30	R:R:V34	1.46	No	No	0	3	4
263	R:R:P138	R:R:R137	1.44	No	Yes	5	7	7
264	R:R:P138	R:R:R140	1.44	No	No	5	7	4
265	R:R:P293	R:R:R292	1.44	No	Yes	0	5	6
266	R:R:H74	R:R:V77	1.38	Yes	No	0	9	6
267	R:R:L108	R:R:L112	1.38	No	No	0	5	5
268	R:R:L108	R:R:L169	1.38	No	No	0	5	5
269	R:R:D30	R:R:N28	1.35	No	No	0	3	5
270	R:R:F31	R:R:V34	1.31	No	No	0	5	4
271	R:R:R245	R:R:V249	1.31	No	No	0	5	4
272	R:R:D17	R:R:E20	1.3	No	No	0	7	3
273	R:R:F307	R:R:I57	1.26	Yes	No	0	7	7
274	R:R:F73	R:R:L59	1.22	Yes	No	0	6	3
275	R:R:I57	R:R:Y56	1.21	No	No	0	7	4
276	R:R:L136	R:R:R137	1.21	No	Yes	0	7	7
277	R:R:R151	R:R:W65	1	No	Yes	0	2	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:W16	6.9625	4	0	7
2	R:R:L21	3.0175	4	0	3
3	R:R:C44	3.34	4	0	7
4	R:R:N51	5.4225	4	0	9
5	R:R:F58	16.228	5	2	7
6	R:R:W65	11.528	5	2	6
7	R:R:Y71	5.0625	4	0	7
8	R:R:F73	7.9925	4	2	6
9	R:R:H74	6.1325	4	3	9
10	R:R:Y82	12.016	5	1	7
11	R:R:Y92	6.324	5	4	6
12	R:R:F111	3.01	4	0	6
13	R:R:F113	7.78	4	1	6
14	R:R:Y114	7.5125	4	1	5
15	R:R:Y118	8.0125	4	1	7
16	R:R:F123	6.206	5	3	8
17	R:R:R137	4.4675	4	5	7
18	R:R:R146	7.3725	4	0	7
19	R:R:W158	7.6075	4	3	9
20	R:R:Q165	5.335	4	1	7
21	R:R:F171	6.06	4	1	5
22	R:R:T182	4.0025	4	4	4
23	R:R:F195	7.2675	4	1	2
24	R:R:M202	5.152	5	1	6
25	R:R:L203	4.095	4	1	5
26	R:R:F207	9.7	4	1	8
27	R:R:F211	5.804	5	1	6
28	R:R:I214	5.7975	4	1	7
29	R:R:Y218	6.79667	6	1	9
30	R:R:F254	7.47	5	1	9
31	R:R:F258	10.35	5	1	9
32	R:R:F261	4.68833	6	0	7
33	R:R:H262	10.2625	4	1	8
34	R:R:R265	10.0325	4	1	6
35	R:R:Y268	6.02333	6	0	4
36	R:R:Y269	8.43	4	1	5
37	R:R:L281	3.0175	4	0	1
38	R:R:M286	5.896	5	0	1
39	R:R:Y288	5.475	4	0	5
40	R:R:R292	5.8875	4	0	6
41	R:R:Y306	7.72333	6	1	9
42	R:R:F307	5.015	4	0	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:T15	R:R:W16	10.4442	3.64	No	Yes	0	6	7
2	R:R:R272	R:R:Y268	19.0504	7.2	No	Yes	0	3	4
3	R:R:T15	R:R:Y268	13.9786	8.74	No	Yes	0	6	4
4	R:R:M286	R:R:Y33	13.5662	3.59	Yes	No	0	1	5
5	R:R:K289	R:R:M286	20.7587	5.76	No	Yes	0	5	1
6	R:R:K289	R:R:Y288	22.1902	3.58	No	Yes	0	5	5
7	R:R:Y268	R:R:Y288	33.5238	5.96	Yes	Yes	0	4	5
8	R:R:G47	R:R:L46	11.1864	1.71	No	No	0	8	6
9	R:R:G47	R:R:N51	17.7604	5.09	No	Yes	0	8	9
10	R:R:D79	R:R:N51	32.6873	5.39	No	Yes	0	9	9
11	R:R:D79	R:R:N116	34.6784	5.39	No	No	1	9	8
12	R:R:N116	R:R:Y82	38.9079	17.44	No	Yes	1	8	7
13	R:R:F113	R:R:Y82	96.4303	12.38	Yes	Yes	1	6	7
14	R:R:F113	R:R:R292	51.237	9.62	Yes	Yes	0	6	6
15	R:R:R292	R:R:Y288	53.3518	8.23	Yes	Yes	0	6	5
16	R:R:L89	R:R:Y40	45.0224	7.03	No	No	0	6	8
17	R:R:Y40	R:R:Y82	46.7778	3.97	No	Yes	0	8	7
18	R:R:C44	R:R:L86	15.5808	6.35	Yes	No	0	7	8
19	R:R:L86	R:R:Y82	17.7604	19.93	No	Yes	0	8	7
20	R:R:N51	R:R:P303	11.1864	6.52	Yes	No	0	9	9
21	R:R:F307	R:R:F58	16.4291	8.57	Yes	Yes	0	7	7
22	R:R:F307	R:R:M72	27.4505	7.46	Yes	No	0	7	8
23	R:R:M72	R:R:Y306	53.1751	7.18	No	Yes	0	8	9
24	R:R:L124	R:R:Y306	63.9079	8.21	No	Yes	1	8	9
25	R:R:F254	R:R:L124	84.5606	8.53	Yes	No	1	9	8
26	R:R:F254	R:R:F258	89.1671	8.57	Yes	Yes	1	9	9
27	R:R:F258	R:R:L117	99.3344	9.74	Yes	No	0	9	7
28	R:R:F261	R:R:L117	100	3.65	Yes	No	0	7	7
29	R:R:F261	R:R:Y288	71.7778	4.13	Yes	Yes	0	7	5
30	R:R:I127	R:R:Y306	12.4057	7.25	No	Yes	0	9	9
31	R:R:H130	R:R:S68	26.1133	6.97	No	No	0	8	8
32	R:R:M72	R:R:S68	27.7274	3.07	No	No	0	8	8
33	R:R:F123	R:R:L75	22.1254	8.53	Yes	No	0	8	9
34	R:R:L75	R:R:N302	23.7453	5.49	No	No	0	9	9
35	R:R:L124	R:R:N302	19.6984	4.12	No	No	1	8	9
36	R:R:L89	R:R:V109	11.1864	4.47	No	No	0	6	5
37	R:R:L89	R:R:Y92	32.6873	3.52	No	Yes	0	6	6
38	R:R:T182	R:R:Y92	19.8221	3.75	Yes	Yes	4	4	6
39	R:R:T103	R:R:T174	11.1864	6.28	No	No	0	3	5
40	R:R:T174	R:R:T182	13.3895	3.14	No	Yes	0	5	4
41	R:R:F111	R:R:Q165	12.7356	3.51	Yes	Yes	0	6	7
42	R:R:Q165	R:R:Y114	13.8254	4.51	Yes	Yes	1	7	5
43	R:R:R265	R:R:Y114	46.984	10.29	Yes	Yes	1	6	5
44	R:R:R265	R:R:Y269	17.2184	11.32	Yes	Yes	1	6	5
45	R:R:F261	R:R:H262	19.2861	5.66	Yes	Yes	0	7	8
46	R:R:H262	R:R:Y118	22.3845	7.62	Yes	Yes	1	8	7
47	R:R:M202	R:R:Y118	10.7328	8.38	Yes	Yes	1	6	7
48	R:R:F254	R:R:I214	21.7719	7.54	Yes	Yes	1	9	7
49	R:R:I214	R:R:Y218	18.0372	3.63	Yes	Yes	1	7	9
50	R:R:M221	R:R:R131	16.9828	6.2	No	No	0	8	9
51	R:R:R131	R:R:Y218	15.033	5.14	No	Yes	0	9	9
52	R:R:L133	R:R:R146	18.4908	4.86	No	Yes	0	5	7
53	R:R:H130	R:R:R146	23.0384	13.54	No	Yes	0	8	7
54	R:R:L133	R:R:R137	15.1803	2.43	No	Yes	0	5	7
55	R:R:F195	R:R:Y269	15.9402	11.35	Yes	Yes	1	2	5
56	R:R:F207	R:R:H262	22.0429	22.63	Yes	Yes	1	8	8
57	R:R:F207	R:R:F211	21.5363	6.43	Yes	Yes	1	8	6
58	R:R:L305	R:R:Y306	10.1673	5.86	No	Yes	0	8	9
59	R:R:F113	R:R:Y114	52.4623	5.16	Yes	Yes	1	6	5
60	R:R:F261	R:R:R265	49.405	5.34	Yes	Yes	0	7	6
61	R:R:Q165	R:R:Y118	14.9564	9.02	Yes	Yes	1	7	7
62	R:R:F211	R:R:F254	16.1463	6.43	Yes	Yes	1	6	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 9K25_nogp

PDB Summary
PDB	9K25_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.58
Number of Linked Nodes	252
Number of Links	277
Number of Hubs	42
Number of Links mediated by Hubs	152
Number of Communities	5
Number of Nodes involved in Communities	47
Number of Links involved in Communities	60

Path Summary
Number Of Nodes in MetaPath	63
Number Of Links MetaPath	62
Number of Shortest Paths	38468
Length Of Smallest Path	3
Average Path Length	12.3248
Length of Longest Path	28
Minimum Path Strength	1.235
Average Path Strength	6.8309
Maximum Path Strength	19.965
Minimum Path Correlation	0.7
Average Path Correlation	0.917236
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	48.4243
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.462
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • G-protein beta/gamma-subunit complex binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Biological Process
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • molecular transducer activity • signaling receptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • G protein-coupled pyrimidinergic nucleotide receptor activity • nucleotide receptor activity • G protein-coupled UTP receptor activity • A1 adenosine receptor binding • signaling receptor binding • G protein-coupled receptor binding • adenosine receptor binding • G protein-coupled purinergic nucleotide receptor activity • purinergic nucleotide receptor activity • regulation of localization • regulation of body fluid levels • secretion by tissue • regulation of transport • transport • secretion • regulation of mucus secretion • positive regulation of biological process • establishment of localization • mucus secretion • regulation of secretion • localization • body fluid secretion • positive regulation of secretion • positive regulation of transport • positive regulation of mucus secretion • positive regulation of multicellular organismal process • regulation of multicellular organismal process • regulation of biological quality • cellular homeostasis • chemical homeostasis • homeostatic process • monoatomic ion homeostasis • intracellular chemical homeostasis • intracellular monoatomic ion homeostasis • cellular response to ATP • response to organophosphorus • response to ATP • response to purine-containing compound • regulation of tube diameter • regulation of tube size • circulatory system process • vascular process in circulatory system • blood vessel diameter maintenance • blood circulation • regulation of anatomical structure size • purinergic nucleotide receptor signaling pathway • cell surface receptor signaling pathway • G protein-coupled purinergic nucleotide receptor signaling pathway • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P41231
Sequence	>9K25_nogp_Chain_R T W D G D E L G Y R C R F N E D F K Y V L L P V S Y G V V C V G L C L N A V A L Y I F L C R L K T W N A S T T Y M F H L A V S D A L Y A A S L P L L V Y Y Y A R G D H W P F S T V L C K L V R F L F Y T N L Y C S I L F L T C I S V H R C L G V L R P L R S L R W G R A R Y A R R V A G A V W V L V L A C Q A P V L Y F V T T S A T C H D T S A P E L F S R F V A Y S S V M L G L L F A V P F A V I L V C Y V L M A R R L L K A K R K S V R T I A V V L A V F A L C F L P F H V T R T L Y Y S F R S L D L S C H T L N A I N M A Y K V T R P L A S A N S C L P V L Y F L L N Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9K20	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-	chim(NtGi1-Go)/β1/γ2	2.65	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K20 (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-		2.65	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0X	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.83	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K0X (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	ATP	-		2.83	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K25	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	-	-	chim(NtGi1-Gs-CtGq)/β1/γ2	3.31	2025-06-11	doi.org/10.1038/s41421-025-00797-x
	9K25 (No Gprot)	A	Nucleotide	P2Y	P2Y₂	Homo sapiens	-	-		3.31	2025-06-11	doi.org/10.1038/s41421-025-00797-x

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9K25_nogp.zip

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