psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:D14	L:L:I15	5.6	No	No	0	0	0
2	L:L:N16	L:L:P17	4.89	Yes	No	0	0	0
3	L:L:N16	L:L:Y20	8.14	Yes	Yes	2	0	0
4	L:L:N16	R:R:V201	4.43	Yes	No	0	0	1
5	L:L:N16	R:R:F214	13.29	Yes	Yes	2	0	4
6	L:L:S22	L:L:W19	6.18	No	No	0	0	0
7	L:L:R23	L:L:W19	4	No	No	0	0	0
8	L:L:Y20	R:R:L210	7.03	Yes	Yes	2	0	4
9	L:L:Y20	R:R:E212	7.86	Yes	Yes	2	0	4
10	L:L:Y20	R:R:F214	7.22	Yes	Yes	2	0	4
11	L:L:I25	L:L:R23	8.77	Yes	No	0	0	0
12	L:L:R23	R:R:H306	13.54	No	No	0	0	2
13	L:L:I25	L:L:P27	5.08	Yes	Yes	2	0	0
14	L:L:I25	R:R:F313	12.56	Yes	Yes	2	0	4
15	L:L:R26	R:R:L53	10.93	No	No	0	0	3
16	L:L:R26	R:R:Y120	10.29	No	No	0	0	5
17	L:L:P27	R:R:E212	7.86	Yes	Yes	2	0	4
18	L:L:P27	R:R:R301	12.97	Yes	No	0	0	4
19	L:L:P27	R:R:F313	4.33	Yes	Yes	2	0	4
20	L:L:P27	R:R:Q317	4.74	Yes	Yes	2	0	4
21	L:L:V28	R:R:Q317	5.73	No	Yes	0	0	4
22	L:L:R30	R:R:Y225	5.14	Yes	No	1	0	5
23	L:L:R30	R:R:L229	4.86	Yes	No	1	0	4
24	L:L:R30	R:R:N298	9.64	Yes	No	0	0	6
25	L:L:R30	R:R:D302	4.76	Yes	No	0	0	5
26	L:L:?33	L:L:F31	6.03	Yes	Yes	1	0	0
27	L:L:F31	R:R:P142	4.33	Yes	No	1	0	5
28	L:L:F31	R:R:V145	19.66	Yes	No	1	0	7
29	L:L:F31	R:R:Y146	6.19	Yes	Yes	1	0	7
30	L:L:F31	R:R:L294	3.65	Yes	No	0	0	7
31	L:L:F31	R:R:H295	4.53	Yes	Yes	0	0	8
32	L:L:?33	R:R:C113	3.93	Yes	No	1	0	7
33	L:L:?33	R:R:T117	7.3	Yes	No	1	0	6
34	L:L:?33	R:R:Q141	16.47	Yes	Yes	1	0	6
35	L:L:?33	R:R:H321	6.36	Yes	Yes	1	0	5
36	R:R:L55	R:R:Q58	5.32	No	No	0	3	2
37	R:R:L55	R:R:Y311	4.69	No	No	0	3	3
38	R:R:L315	R:R:L55	5.54	No	No	0	1	3
39	R:R:L59	R:R:Q58	5.32	No	No	0	4	2
40	R:R:F122	R:R:K60	13.65	Yes	No	0	4	5
41	R:R:F122	R:R:I63	6.28	Yes	No	0	4	5
42	R:R:L66	R:R:W322	14.81	No	Yes	0	5	5
43	R:R:V114	R:R:Y67	6.31	No	Yes	0	7	8
44	R:R:H321	R:R:Y67	9.8	Yes	Yes	0	5	8
45	R:R:W322	R:R:Y67	16.4	Yes	Yes	0	5	8
46	R:R:V70	R:R:W322	7.36	No	Yes	5	7	5
47	R:R:S326	R:R:V70	4.85	No	No	5	5	7
48	R:R:V114	R:R:V71	9.62	No	No	0	7	7
49	R:R:G77	R:R:V76	3.68	No	Yes	0	8	5
50	R:R:G77	R:R:P332	4.06	No	No	0	8	9
51	R:R:A103	R:R:N78	4.69	Yes	No	0	9	9
52	R:R:D106	R:R:N78	8.08	Yes	No	0	9	9
53	R:R:N78	R:R:P332	9.77	No	No	0	9	9
54	R:R:I85	R:R:L81	5.71	No	No	0	7	9
55	R:R:A103	R:R:L81	4.73	Yes	No	0	9	9
56	R:R:A336	R:R:L81	4.73	No	No	0	7	9
57	R:R:E345	R:R:V84	7.13	Yes	No	0	5	8
58	R:R:I85	R:R:N96	12.74	No	Yes	0	7	8
59	R:R:L91	R:R:V88	4.47	Yes	No	0	7	5
60	R:R:E345	R:R:V88	7.13	Yes	No	0	5	5
61	R:R:H92	R:R:R89	11.28	No	No	0	6	6
62	R:R:L91	R:R:R90	4.86	Yes	No	0	7	5
63	R:R:L91	R:R:N96	6.87	Yes	Yes	7	7	8
64	R:R:F342	R:R:L91	3.65	Yes	Yes	7	8	7
65	R:R:N93	R:R:T95	5.85	No	No	0	7	8
66	R:R:N93	R:R:N96	4.09	No	Yes	0	7	8
67	R:R:R170	R:R:V94	3.92	Yes	No	0	4	6
68	R:R:D158	R:R:T95	5.78	Yes	No	0	8	8
69	R:R:F342	R:R:N96	7.25	Yes	Yes	7	8	8
70	R:R:F97	R:R:S176	7.93	No	No	0	6	7
71	R:R:I155	R:R:L98	4.28	No	No	0	8	7
72	R:R:D158	R:R:L98	4.07	Yes	No	0	8	7
73	R:R:I99	R:R:Y335	3.63	No	Yes	0	8	9
74	R:R:N101	R:R:T151	4.39	No	No	0	9	7
75	R:R:N101	R:R:V180	7.39	No	No	0	9	7
76	R:R:D106	R:R:L102	4.07	Yes	Yes	4	9	9
77	R:R:L102	R:R:T151	7.37	Yes	No	0	9	7
78	R:R:L102	R:R:L152	4.15	Yes	Yes	4	9	8
79	R:R:I155	R:R:L102	4.28	No	Yes	0	8	9
80	R:R:L102	R:R:N331	4.12	Yes	Yes	4	9	9
81	R:R:S105	R:R:V147	4.85	No	No	0	8	7
82	R:R:S105	R:R:S148	6.52	No	No	0	8	9
83	R:R:D106	R:R:S148	4.42	Yes	No	0	9	9
84	R:R:A328	R:R:D106	6.18	No	Yes	0	9	9
85	R:R:D106	R:R:N331	4.04	Yes	Yes	4	9	9
86	R:R:M109	R:R:V145	4.56	No	No	0	8	7
87	R:R:M109	R:R:S148	6.13	No	No	0	8	9
88	R:R:M109	R:R:W291	4.65	No	Yes	0	8	8
89	R:R:C113	R:R:Q141	4.58	No	Yes	1	7	6
90	R:R:C113	R:R:M325	4.86	No	No	0	7	7
91	R:R:P115	R:R:V114	7.07	No	No	0	8	7
92	R:R:L116	R:R:V137	7.45	No	No	0	6	6
93	R:R:Q141	R:R:T117	5.67	Yes	No	1	6	6
94	R:R:H321	R:R:T117	8.21	Yes	No	1	5	6
95	R:R:F122	R:R:L118	3.65	Yes	No	0	4	7
96	R:R:W127	R:R:Y120	3.86	Yes	No	0	8	5
97	R:R:E123	R:R:P124	4.72	No	No	0	4	4
98	R:R:E123	R:R:G126	4.91	No	No	0	4	5
99	R:R:R125	R:R:V128	3.92	Yes	No	3	5	3
100	R:R:D207	R:R:R125	21.44	No	Yes	0	4	5
101	R:R:R125	R:R:R209	9.6	Yes	No	3	5	5
102	R:R:F129	R:R:W127	21.05	No	Yes	0	7	8
103	R:R:C134	R:R:W127	5.22	No	Yes	3	9	8
104	R:R:H200	R:R:W127	8.46	No	Yes	0	5	8
105	R:R:C211	R:R:W127	7.84	No	Yes	3	9	8
106	R:R:R209	R:R:V128	9.15	No	No	3	5	3
107	R:R:F129	R:R:L133	6.09	No	No	0	7	6
108	R:R:G131	R:R:H200	6.35	No	No	0	2	5
109	R:R:C134	R:R:C211	7.28	No	No	3	9	9
110	R:R:H135	R:R:T198	6.85	No	No	0	7	5
111	R:R:F138	R:R:V137	3.93	No	No	0	5	6
112	R:R:Q141	R:R:V137	4.3	Yes	No	0	6	6
113	R:R:C211	R:R:F138	11.17	No	No	0	9	5
114	R:R:F139	R:R:V143	3.93	Yes	No	0	6	5
115	R:R:F139	R:R:L192	4.87	Yes	No	0	6	4
116	R:R:P142	R:R:Y146	4.17	No	Yes	1	5	7
117	R:R:A191	R:R:P142	3.74	No	No	0	7	5
118	R:R:S187	R:R:V143	6.46	No	No	0	8	5
119	R:R:V145	R:R:Y146	3.79	No	Yes	1	7	7
120	R:R:L190	R:R:Y146	4.69	Yes	Yes	0	5	7
121	R:R:L229	R:R:Y146	5.86	No	Yes	1	4	7
122	R:R:T233	R:R:Y146	7.49	No	Yes	0	5	7
123	R:R:V147	R:R:W184	9.81	No	No	0	7	9
124	R:R:P237	R:R:V149	3.53	No	No	0	9	8
125	R:R:F287	R:R:V149	5.24	Yes	No	0	9	8
126	R:R:F150	R:R:I183	6.28	No	No	0	6	7
127	R:R:I241	R:R:L152	4.28	No	Yes	0	8	8
128	R:R:F287	R:R:L152	4.87	Yes	Yes	0	9	8
129	R:R:L152	R:R:N331	4.12	Yes	Yes	4	8	9
130	R:R:L152	R:R:Y335	4.69	Yes	Yes	0	8	9
131	R:R:I155	R:R:Y335	3.63	No	Yes	0	8	9
132	R:R:A156	R:R:I241	4.87	No	No	0	9	8
133	R:R:A156	R:R:Y245	4	No	Yes	0	9	9
134	R:R:D158	R:R:V162	4.38	Yes	No	8	8	8
135	R:R:D158	R:R:R170	8.34	Yes	Yes	8	8	4
136	R:R:R159	R:R:Y245	7.2	No	Yes	0	9	9
137	R:R:R159	R:R:Y335	6.17	No	Yes	0	9	9
138	R:R:V164	R:R:Y160	12.62	No	Yes	0	7	8
139	R:R:S244	R:R:Y160	5.09	No	Yes	0	8	8
140	R:R:R247	R:R:Y160	7.2	No	Yes	0	4	8
141	R:R:R170	R:R:V162	5.23	Yes	No	8	4	8
142	R:R:H165	R:R:V164	8.3	No	No	0	6	7
143	R:R:L175	R:R:S172	4.5	No	No	0	4	4
144	R:R:P193	R:R:Y225	11.13	No	No	0	8	5
145	R:R:H197	R:R:V196	5.54	No	No	0	5	4
146	R:R:E213	R:R:H197	4.92	No	No	9	5	5
147	R:R:H197	R:R:W215	28.56	No	Yes	9	5	5
148	R:R:L210	R:R:V201	4.47	Yes	No	0	4	1
149	R:R:E202	R:R:K204	12.15	No	No	0	2	1
150	R:R:L203	R:R:P205	13.14	No	No	0	1	4
151	R:R:D207	R:R:H206	16.39	No	No	0	4	1
152	R:R:H206	R:R:V208	6.92	No	No	0	1	3
153	R:R:E212	R:R:L210	14.58	Yes	Yes	2	4	4
154	R:R:F214	R:R:L210	12.18	Yes	Yes	2	4	4
155	R:R:E212	R:R:F214	8.16	Yes	Yes	2	4	4
156	R:R:E213	R:R:W215	13.08	No	Yes	9	5	5
157	R:R:Q221	R:R:W215	6.57	No	Yes	0	4	5
158	R:R:R222	R:R:W215	13	No	Yes	0	4	5
159	R:R:Q218	R:R:Q221	23.04	No	No	0	1	4
160	R:R:E219	R:R:R220	16.28	No	No	0	4	4
161	R:R:E219	R:R:Q223	11.47	No	No	0	4	3
162	R:R:D302	R:R:R222	15.48	No	No	0	5	4
163	R:R:P305	R:R:R222	8.65	No	No	0	3	4
164	R:R:L303	R:R:Q223	3.99	No	No	0	4	3
165	R:R:L229	R:R:Y225	15.24	No	No	1	4	5
166	R:R:L299	R:R:W227	14.81	No	No	0	5	5
167	R:R:L230	R:R:L235	4.15	No	No	0	6	4
168	R:R:L231	R:R:L235	4.15	No	No	0	5	4
169	R:R:H295	R:R:T233	5.48	Yes	No	0	8	5
170	R:R:L235	R:R:Y234	4.69	No	No	0	4	8
171	R:R:L292	R:R:Y234	7.03	No	No	0	5	8
172	R:R:H295	R:R:Y234	13.07	Yes	No	0	8	8
173	R:R:L236	R:R:P237	6.57	No	No	0	5	9
174	R:R:F287	R:R:L238	6.09	Yes	No	0	9	6
175	R:R:S244	R:R:Y245	3.82	No	Yes	0	8	9
176	R:R:L280	R:R:Y245	12.89	No	Yes	0	7	9
177	R:R:V284	R:R:Y245	3.79	No	Yes	0	7	9
178	R:R:K251	R:R:R247	9.9	No	No	0	5	4
179	R:R:F277	R:R:S249	11.89	Yes	No	0	6	5
180	R:R:F277	R:R:R253	8.55	Yes	No	0	6	5
181	R:R:P258	R:R:V257	3.53	No	No	0	4	4
182	R:R:Q263	R:R:S264	10.11	No	No	0	4	4
183	R:R:Q263	R:R:Q265	10.24	No	No	0	4	1
184	R:R:D269	R:R:R270	10.72	No	No	0	4	3
185	R:R:R270	R:R:R273	14.93	No	No	0	3	7
186	R:R:F277	R:R:R273	7.48	Yes	No	0	6	7
187	R:R:F277	R:R:T276	3.89	Yes	No	0	6	7
188	R:R:I283	R:R:I334	5.89	No	Yes	10	7	8
189	R:R:V286	R:R:Y330	3.79	No	No	0	7	6
190	R:R:F287	R:R:W291	7.02	Yes	Yes	0	9	8
191	R:R:H295	R:R:W291	4.23	Yes	Yes	0	8	8
192	R:R:S327	R:R:W291	3.71	No	Yes	0	9	8
193	R:R:C320	R:R:P293	3.77	No	No	0	7	9
194	R:R:L323	R:R:P293	4.93	No	No	0	8	9
195	R:R:L294	R:R:N298	4.12	No	No	0	7	6
196	R:R:A324	R:R:L294	4.73	No	No	0	8	7
197	R:R:F297	R:R:F313	10.72	No	Yes	2	4	4
198	R:R:F297	R:R:V316	6.55	No	No	0	4	5
199	R:R:F297	R:R:Q317	9.37	No	Yes	2	4	4
200	R:R:I308	R:R:L300	4.28	No	No	0	1	5
201	R:R:D302	R:R:R301	7.15	No	No	0	5	4
202	R:R:A307	R:R:D304	6.18	No	No	0	2	3
203	R:R:D309	R:R:I308	12.59	No	No	0	1	1
204	R:R:D309	R:R:F313	4.78	No	Yes	0	1	4
205	R:R:D309	R:R:V316	5.84	No	No	0	1	5
206	R:R:F313	R:R:Q317	7.03	Yes	Yes	2	4	4
207	R:R:H321	R:R:M325	6.57	Yes	No	0	5	7
208	R:R:S326	R:R:W322	7.41	No	Yes	5	5	5
209	R:R:N331	R:R:S327	4.47	Yes	No	0	9	9
210	R:R:C329	R:R:Y330	4.03	No	No	0	7	6
211	R:R:F333	R:R:W337	9.02	No	No	0	6	7
212	R:R:I334	R:R:Y335	3.63	Yes	Yes	0	8	9
213	R:R:A336	R:R:F342	5.55	No	Yes	0	7	8
214	R:R:L346	R:R:W337	4.56	No	No	0	7	7
215	R:R:D340	R:R:R343	3.57	No	No	0	5	8
216	R:R:F342	R:R:S341	3.96	Yes	No	0	8	6
217	R:R:E345	R:R:K348	6.75	Yes	No	0	5	4
218	R:R:E345	R:R:L349	5.3	Yes	No	0	5	6
219	R:R:L118	R:R:Y67	3.52	No	Yes	0	7	8
220	R:R:L318	R:R:Y67	3.52	No	Yes	0	3	8
221	R:R:P237	R:R:T153	3.5	No	No	0	9	7
222	R:R:Q221	R:R:R220	3.5	No	No	0	4	4
223	R:R:E123	R:R:R125	3.49	No	Yes	0	4	5
224	R:R:C290	R:R:S327	3.44	No	No	0	9	9
225	R:R:C110	R:R:V71	3.42	No	No	0	6	7
226	R:R:C329	R:R:V73	3.42	No	No	0	7	5
227	R:R:C260	R:R:V257	3.42	No	No	0	3	4
228	R:R:H165	R:R:R168	3.39	No	No	0	6	4
229	R:R:L292	R:R:P293	3.28	No	No	0	5	9
230	R:R:S68	R:R:V69	3.23	No	No	0	5	4
231	R:R:S187	R:R:V147	3.23	No	No	0	8	7
232	R:R:D304	R:R:P305	3.22	No	No	0	3	3
233	R:R:G130	R:R:H200	3.18	No	No	0	8	5
234	R:R:T153	R:R:V240	3.17	No	No	0	7	7
235	R:R:A288	R:R:L238	3.15	No	No	0	6	6
236	R:R:A312	R:R:L315	3.15	No	No	0	4	1
237	R:R:I334	R:R:V282	3.07	Yes	No	0	8	6
238	R:R:I183	R:R:T154	3.04	No	No	0	7	7
239	R:R:K251	R:R:V250	3.04	No	No	0	5	3
240	R:R:L173	R:R:S176	3	No	No	0	6	7
241	R:R:R272	R:R:W268	3	No	No	0	5	3
242	R:R:L80	R:R:V76	2.98	No	Yes	0	6	5
243	R:R:L346	R:R:V84	2.98	No	No	0	7	8
244	R:R:L163	R:R:V248	2.98	No	No	0	8	8
245	R:R:L98	R:R:T154	2.95	No	No	0	7	7
246	R:R:L108	R:R:T144	2.95	No	No	0	7	8
247	R:R:C134	R:R:H135	2.95	No	No	0	9	7
248	R:R:L280	R:R:T276	2.95	No	No	0	7	7
249	R:R:I171	R:R:L175	2.85	No	No	0	4	4
250	R:R:I334	R:R:L338	2.85	Yes	No	0	8	7
251	R:R:A119	R:R:F129	2.77	No	No	0	5	7
252	R:R:A188	R:R:F139	2.77	No	Yes	0	4	6
253	R:R:A195	R:R:F139	2.77	No	Yes	0	5	6
254	R:R:L230	R:R:L299	2.77	No	No	0	6	5
255	R:R:F122	R:R:V56	2.62	Yes	No	0	4	2
256	R:R:F122	R:R:V64	2.62	Yes	No	0	4	5
257	R:R:F97	R:R:V180	2.62	No	No	0	6	7
258	R:R:V248	R:R:Y160	2.52	No	Yes	0	8	8
259	R:R:I171	R:R:R170	2.51	No	Yes	0	4	4
260	R:R:F277	R:R:L252	2.44	Yes	No	0	6	8
261	R:R:L349	R:R:R87	2.43	No	No	0	6	5
262	R:R:N254	R:R:R253	2.41	No	No	0	4	5
263	R:R:L108	R:R:W184	2.28	No	No	0	7	9
264	R:R:R168	R:R:R169	2.13	No	No	0	4	6
265	R:R:R273	R:R:R274	2.13	No	No	0	7	5
266	R:R:G131	R:R:G132	2.11	No	No	0	2	2
267	R:R:G259	R:R:P258	2.03	No	No	0	2	4
268	R:R:R209	R:R:W127	2	No	Yes	3	5	8
269	R:R:C329	R:R:G74	1.96	No	No	0	7	8
270	R:R:A103	R:R:G100	1.95	Yes	No	0	9	6
271	R:R:G216	R:R:S217	1.86	No	No	0	3	3
272	R:R:G314	R:R:V56	1.84	No	No	0	3	2
273	R:R:G61	R:R:K60	1.74	No	No	0	3	5
274	R:R:G61	R:R:L65	1.71	No	No	0	3	6
275	R:R:C79	R:R:V107	1.71	No	No	0	4	7
276	R:R:A266	R:R:S264	1.71	No	No	0	3	4
277	R:R:C278	R:R:V282	1.71	No	No	0	5	6
278	R:R:C290	R:R:V286	1.71	No	No	0	9	7
279	R:R:C290	R:R:V289	1.71	No	No	0	9	6
280	L:L:V28	R:R:A121	1.7	No	No	0	0	5
281	R:R:A103	R:R:V82	1.7	Yes	No	0	9	7
282	L:L:I25	R:R:P310	1.69	Yes	No	0	0	3
283	R:R:C260	R:R:T262	1.69	No	No	0	3	3
284	R:R:A112	R:R:T144	1.68	No	No	0	3	8
285	R:R:K204	R:R:P205	1.67	No	No	0	1	4
286	L:L:G24	R:R:Q54	1.64	No	No	0	0	3
287	R:R:V69	R:R:V73	1.6	No	No	0	4	5
288	R:R:V72	R:R:V73	1.6	No	No	0	6	5
289	R:R:V72	R:R:V76	1.6	No	Yes	6	6	5
290	R:R:V157	R:R:V161	1.6	No	No	0	6	5
291	R:R:V157	R:R:V240	1.6	No	No	0	6	7
292	R:R:V246	R:R:V250	1.6	No	No	0	3	3
293	R:R:V285	R:R:V286	1.6	No	No	0	4	7
294	R:R:A112	R:R:L140	1.58	No	No	0	3	5
295	R:R:A226	R:R:L299	1.58	No	No	0	5	5
296	R:R:H165	R:R:P166	1.53	No	No	0	6	8
297	R:R:A194	R:R:E213	1.51	No	No	0	4	5
298	L:L:G29	R:R:R301	1.5	No	No	0	0	4
299	R:R:L315	R:R:V56	1.49	No	No	0	1	2
300	R:R:L75	R:R:V71	1.49	No	No	0	6	7
301	R:R:L75	R:R:V72	1.49	No	No	6	6	6
302	R:R:L75	R:R:V76	1.49	No	Yes	6	6	5
303	R:R:L104	R:R:V82	1.49	No	No	0	6	7
304	R:R:L104	R:R:V107	1.49	No	No	0	6	7
305	R:R:L190	R:R:V189	1.49	Yes	No	0	5	4
306	R:R:L190	R:R:V232	1.49	Yes	No	0	5	4
307	R:R:L203	R:R:V208	1.49	No	No	0	1	3
308	R:R:L242	R:R:V246	1.49	No	No	0	4	3
309	R:R:L242	R:R:V284	1.49	No	No	0	4	7
310	R:R:L108	R:R:T111	1.47	No	No	0	7	4
311	R:R:D340	R:R:S341	1.47	No	No	0	5	6
312	R:R:I63	R:R:L319	1.43	No	No	0	5	5
313	R:R:I283	R:R:L279	1.43	No	No	10	7	8
314	R:R:I334	R:R:L279	1.43	Yes	No	10	8	8
315	R:R:Q263	R:R:T262	1.42	No	No	0	4	3
316	R:R:H339	R:R:S341	1.39	No	No	0	8	6
317	R:R:L186	R:R:L190	1.38	No	Yes	0	4	5
318	R:R:L53	R:R:Q54	1.33	No	No	0	3	3
319	R:R:R174	R:R:S172	1.32	No	No	0	6	4
320	R:R:H57	R:R:L53	1.29	No	No	0	4	3
321	R:R:V201	R:R:Y199	1.26	No	No	0	1	4
322	R:R:L252	R:R:R255	1.21	No	No	0	8	6
323	R:R:L279	R:R:R275	1.21	No	No	0	8	7
324	R:R:L346	R:R:R347	1.21	No	No	0	7	5
325	R:R:E344	R:R:R347	1.16	No	No	0	4	5
326	L:L:D14	R:R:Y199	1.15	No	No	0	0	4
327	R:R:R174	R:R:Y178	1.03	No	No	0	6	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:N16	7.6875	4	2	0
2	L:L:Y20	7.5625	4	2	0
3	L:L:I25	7.025	4	2	0
4	L:L:P27	6.996	5	2	0
5	L:L:R30	6.1	4	1	0
6	L:L:F31	7.39833	6	1	0
7	L:L:?33	8.018	5	1	0
8	R:R:Y67	7.91	5	0	8
9	R:R:V76	2.4375	4	6	5
10	R:R:L91	4.9625	4	7	7
11	R:R:N96	7.7375	4	7	8
12	R:R:L102	4.798	5	4	9
13	R:R:A103	3.2675	4	0	9
14	R:R:D106	5.358	5	4	9
15	R:R:F122	5.764	5	0	4
16	R:R:R125	9.6125	4	3	5
17	R:R:W127	8.07167	6	3	8
18	R:R:F139	3.585	4	0	6
19	R:R:Q141	7.755	4	1	6
20	R:R:Y146	5.365	6	1	7
21	R:R:L152	4.422	5	4	8
22	R:R:D158	5.6425	4	8	8
23	R:R:Y160	6.8575	4	0	8
24	R:R:R170	5	4	8	4
25	R:R:L190	2.2625	4	0	5
26	R:R:L210	9.565	4	2	4
27	R:R:E212	9.615	4	2	4
28	R:R:F214	10.2125	4	2	4
29	R:R:W215	15.3025	4	9	5
30	R:R:Y245	6.34	5	0	9
31	R:R:F277	6.85	5	0	6
32	R:R:F287	5.805	4	0	9
33	R:R:W291	4.9025	4	0	8
34	R:R:H295	6.8275	4	0	8
35	R:R:F313	7.884	5	2	4
36	R:R:Q317	6.7175	4	2	4
37	R:R:H321	7.735	4	1	5
38	R:R:W322	11.495	4	5	5
39	R:R:N331	4.1875	4	4	9
40	R:R:I334	3.374	5	10	8
41	R:R:Y335	4.35	5	0	9
42	R:R:F342	5.1025	4	7	8
43	R:R:E345	6.5775	4	0	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E212	R:R:L210	10.8253	14.58	Yes	Yes	2	4	4
2	L:L:P27	R:R:E212	25.898	7.86	Yes	Yes	2	0	4
3	L:L:I25	L:L:P27	12.9164	5.08	Yes	Yes	2	0	0
4	L:L:P27	R:R:F313	14.995	4.33	Yes	Yes	2	0	4
5	L:L:P27	R:R:R301	64.9453	12.97	Yes	No	0	0	4
6	R:R:D302	R:R:R301	68.9691	7.15	No	No	0	5	4
7	L:L:R30	R:R:D302	100	4.76	Yes	No	0	0	5
8	L:L:R30	R:R:L229	73.3936	4.86	Yes	No	1	0	4
9	R:R:L229	R:R:Y146	77.6442	5.86	No	Yes	1	4	7
10	L:L:F31	R:R:Y146	32.4292	6.19	Yes	Yes	1	0	7
11	L:L:?33	L:L:F31	72.7846	6.03	Yes	Yes	1	0	0
12	L:L:?33	R:R:Q141	43.7609	16.47	Yes	Yes	1	0	6
13	R:R:Q141	R:R:V137	46.8245	4.3	Yes	No	0	6	6
14	R:R:F138	R:R:V137	44.3171	3.93	No	No	0	5	6
15	R:R:C211	R:R:F138	43.0245	11.17	No	No	0	9	5
16	R:R:C211	R:R:W127	37.5715	7.84	No	Yes	3	9	8
17	L:L:R30	R:R:N298	28.278	9.64	Yes	No	0	0	6
18	R:R:L294	R:R:N298	29.148	4.12	No	No	0	7	6
19	L:L:F31	R:R:L294	30.9129	3.65	Yes	No	0	0	7
20	L:L:P27	R:R:Q317	10.6668	4.74	Yes	Yes	2	0	4
21	R:R:V145	R:R:Y146	33.4545	3.79	No	Yes	1	7	7
22	L:L:F31	R:R:H295	70.4822	4.53	Yes	Yes	0	0	8
23	R:R:T233	R:R:Y146	19.2891	7.49	No	Yes	0	5	7
24	R:R:H295	R:R:T233	19.7645	5.48	Yes	No	0	8	5
25	L:L:?33	R:R:H321	32.9356	6.36	Yes	Yes	1	0	5
26	R:R:H321	R:R:Y67	34.9459	9.8	Yes	Yes	0	5	8
27	R:R:L118	R:R:Y67	22.7163	3.52	No	Yes	0	7	8
28	R:R:F122	R:R:L118	21.3429	3.65	Yes	No	0	4	7
29	R:R:F122	R:R:V56	11.5554	2.62	Yes	No	0	4	2
30	R:R:V114	R:R:Y67	12.4565	6.31	No	Yes	0	7	8
31	R:R:V114	R:R:V71	10.9651	9.62	No	No	0	7	7
32	R:R:M109	R:R:V145	49.0865	4.56	No	No	0	8	7
33	R:R:M109	R:R:S148	35.7383	6.13	No	No	0	8	9
34	R:R:D106	R:R:S148	40.3057	4.42	Yes	No	0	9	9
35	R:R:D106	R:R:N78	39.0225	8.08	Yes	No	0	9	9
36	R:R:N78	R:R:P332	12.5715	9.77	No	No	0	9	9
37	R:R:G77	R:R:P332	11.3908	4.06	No	No	0	8	9
38	R:R:L75	R:R:V71	11.1888	1.49	No	No	0	6	7
39	R:R:G77	R:R:V76	10.5611	3.68	No	Yes	0	8	5
40	R:R:A103	R:R:N78	35.2535	4.69	Yes	No	0	9	9
41	R:R:A103	R:R:L81	28.3371	4.73	Yes	No	0	9	9
42	R:R:I85	R:R:L81	12.5062	5.71	No	No	0	7	9
43	R:R:A336	R:R:L81	14.6999	4.73	No	No	0	7	9
44	R:R:I85	R:R:N96	11.4529	12.74	No	Yes	0	7	8
45	R:R:L91	R:R:N96	13.2985	6.87	Yes	Yes	7	7	8
46	R:R:L91	R:R:V88	19.7241	4.47	Yes	No	0	7	5
47	R:R:E345	R:R:V88	17.953	7.13	Yes	No	0	5	5
48	R:R:A336	R:R:F342	13.5254	5.55	No	Yes	0	7	8
49	R:R:E345	R:R:V84	10.8594	7.13	Yes	No	0	5	8
50	R:R:D106	R:R:L102	26.1248	4.07	Yes	Yes	4	9	9
51	R:R:I155	R:R:L102	23.7478	4.28	No	Yes	0	8	9
52	R:R:I155	R:R:L98	26.9202	4.28	No	No	0	8	7
53	R:R:D158	R:R:L98	21.0788	4.07	Yes	No	0	8	7
54	R:R:D158	R:R:R170	11.6766	8.34	Yes	Yes	8	8	4
55	R:R:H295	R:R:W291	90.604	4.23	Yes	Yes	0	8	8
56	R:R:F287	R:R:W291	86.8599	7.02	Yes	Yes	0	9	8
57	R:R:F287	R:R:L152	83.6596	4.87	Yes	Yes	0	9	8
58	R:R:L152	R:R:Y335	53.6664	4.69	Yes	Yes	0	8	9
59	R:R:M109	R:R:W291	20.6966	4.65	No	Yes	0	8	8
60	R:R:S327	R:R:W291	19.4786	3.71	No	Yes	0	9	8
61	R:R:N331	R:R:S327	13.3327	4.47	Yes	No	0	9	9
62	R:R:D106	R:R:N331	13.0904	4.04	Yes	Yes	4	9	9
63	R:R:S105	R:R:S148	18.7453	6.52	No	No	0	8	9
64	R:R:S105	R:R:V147	17.4466	4.85	No	No	0	8	7
65	R:R:R209	R:R:W127	18.7795	2	No	Yes	3	5	8
66	R:R:R125	R:R:R209	15.9241	9.6	Yes	No	3	5	5
67	R:R:D207	R:R:R125	10.2411	21.44	No	Yes	0	4	5
68	R:R:F287	R:R:V149	12.6119	5.24	Yes	No	0	9	8
69	R:R:P237	R:R:V149	10.8284	3.53	No	No	0	9	8
70	R:R:I241	R:R:L152	39.0256	4.28	No	Yes	0	8	8
71	R:R:A156	R:R:I241	37.4254	4.87	No	No	0	9	8
72	R:R:A156	R:R:Y245	35.9433	4	No	Yes	0	9	9
73	R:R:R159	R:R:Y335	44.8142	6.17	No	Yes	0	9	9
74	R:R:R159	R:R:Y245	43.3973	7.2	No	Yes	0	9	9
75	R:R:S244	R:R:Y245	31.6741	3.82	No	Yes	0	8	9
76	R:R:S244	R:R:Y160	28.8249	5.09	No	Yes	0	8	8
77	R:R:V164	R:R:Y160	14.5227	12.62	No	Yes	0	7	8
78	R:R:H165	R:R:V164	11.63	8.3	No	No	0	6	7
79	R:R:D302	R:R:R222	32.2956	15.48	No	No	0	5	4
80	R:R:R222	R:R:W215	23.8193	13	No	Yes	0	4	5
81	R:R:Q221	R:R:W215	13.0841	6.57	No	Yes	0	4	5
82	R:R:H295	R:R:Y234	17.5305	13.07	Yes	No	0	8	8
83	R:R:L280	R:R:Y245	34.3463	12.89	No	Yes	0	7	9
84	R:R:V284	R:R:Y245	11.5554	3.79	No	Yes	0	7	9
85	R:R:L280	R:R:T276	31.497	2.95	No	No	0	7	7
86	R:R:F277	R:R:T276	28.7255	3.89	Yes	No	0	6	7
87	R:R:F277	R:R:R273	11.6238	7.48	Yes	No	0	6	7
88	R:R:I334	R:R:Y335	11.3255	3.63	Yes	Yes	0	8	9
89	R:R:C290	R:R:S327	13.4725	3.44	No	No	0	9	9
90	R:R:C290	R:R:V286	10.5208	1.71	No	No	0	9	7
91	L:L:F31	R:R:V145	15.5232	19.66	Yes	No	1	0	7
92	R:R:L102	R:R:L152	18.1457	4.15	Yes	Yes	4	9	8
93	R:R:I155	R:R:Y335	14.5445	3.63	No	Yes	0	8	9
94	R:R:L152	R:R:N331	11.9563	4.12	Yes	Yes	4	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:N16	R:R:V201	4.43	2	Yes	No	0	1	0	1
L:L:N16	R:R:F214	13.29	2	Yes	Yes	0	4	0	1
L:L:Y20	R:R:L210	7.03	2	Yes	Yes	0	4	0	1
L:L:Y20	R:R:E212	7.86	2	Yes	Yes	0	4	0	1
L:L:Y20	R:R:F214	7.22	2	Yes	Yes	0	4	0	1
L:L:R23	R:R:H306	13.54	0	No	No	0	2	0	1
L:L:I25	R:R:F313	12.56	2	Yes	Yes	0	4	0	1
L:L:R26	R:R:L53	10.93	0	No	No	0	3	0	1
L:L:R26	R:R:Y120	10.29	0	No	No	0	5	0	1
L:L:P27	R:R:E212	7.86	2	Yes	Yes	0	4	0	1
L:L:P27	R:R:R301	12.97	2	Yes	No	0	4	0	1
L:L:P27	R:R:F313	4.33	2	Yes	Yes	0	4	0	1
L:L:P27	R:R:Q317	4.74	2	Yes	Yes	0	4	0	1
L:L:V28	R:R:Q317	5.73	0	No	Yes	0	4	0	1
L:L:R30	R:R:Y225	5.14	1	Yes	No	0	5	0	1
L:L:R30	R:R:L229	4.86	1	Yes	No	0	4	0	1
L:L:R30	R:R:N298	9.64	1	Yes	No	0	6	0	1
L:L:R30	R:R:D302	4.76	1	Yes	No	0	5	0	1
L:L:F31	R:R:P142	4.33	1	Yes	No	0	5	0	1
L:L:F31	R:R:V145	19.66	1	Yes	No	0	7	0	1
L:L:F31	R:R:Y146	6.19	1	Yes	Yes	0	7	0	1
L:L:F31	R:R:L294	3.65	1	Yes	No	0	7	0	1
L:L:F31	R:R:H295	4.53	1	Yes	Yes	0	8	0	1
L:L:?33	R:R:C113	3.93	1	Yes	No	0	7	0	1
L:L:?33	R:R:T117	7.3	1	Yes	No	0	6	0	1
L:L:?33	R:R:Q141	16.47	1	Yes	Yes	0	6	0	1
L:L:?33	R:R:H321	6.36	1	Yes	Yes	0	5	0	1
R:R:H321	R:R:Y67	9.8	1	Yes	Yes	5	8	1	2
R:R:M109	R:R:V145	4.56	0	No	No	8	7	2	1
R:R:M109	R:R:W291	4.65	0	No	Yes	8	8	2	2
R:R:C113	R:R:Q141	4.58	1	No	Yes	7	6	1	1
R:R:C113	R:R:M325	4.86	1	No	No	7	7	1	2
R:R:Q141	R:R:T117	5.67	1	Yes	No	6	6	1	1
R:R:H321	R:R:T117	8.21	1	Yes	No	5	6	1	1
R:R:W127	R:R:Y120	3.86	3	Yes	No	8	5	2	1
R:R:Q141	R:R:V137	4.3	1	Yes	No	6	6	1	2
R:R:P142	R:R:Y146	4.17	1	No	Yes	5	7	1	1
R:R:A191	R:R:P142	3.74	0	No	No	7	5	2	1
R:R:V145	R:R:Y146	3.79	1	No	Yes	7	7	1	1
R:R:L190	R:R:Y146	4.69	0	Yes	Yes	5	7	2	1
R:R:L229	R:R:Y146	5.86	1	No	Yes	4	7	1	1
R:R:T233	R:R:Y146	7.49	0	No	Yes	5	7	2	1
R:R:P193	R:R:Y225	11.13	0	No	No	8	5	2	1
R:R:L210	R:R:V201	4.47	2	Yes	No	4	1	1	1
R:R:E212	R:R:L210	14.58	2	Yes	Yes	4	4	1	1
R:R:F214	R:R:L210	12.18	2	Yes	Yes	4	4	1	1
R:R:E212	R:R:F214	8.16	2	Yes	Yes	4	4	1	1
R:R:D302	R:R:R222	15.48	0	No	No	5	4	1	2
R:R:L229	R:R:Y225	15.24	1	No	No	4	5	1	1
R:R:H295	R:R:T233	5.48	0	Yes	No	8	5	1	2
R:R:H295	R:R:Y234	13.07	0	Yes	No	8	8	1	2
R:R:H295	R:R:W291	4.23	0	Yes	Yes	8	8	1	2
R:R:L294	R:R:N298	4.12	0	No	No	7	6	1	1
R:R:A324	R:R:L294	4.73	0	No	No	8	7	2	1
R:R:F297	R:R:F313	10.72	2	No	Yes	4	4	2	1
R:R:F297	R:R:Q317	9.37	2	No	Yes	4	4	2	1
R:R:D302	R:R:R301	7.15	0	No	No	5	4	1	1
R:R:D309	R:R:F313	4.78	0	No	Yes	1	4	2	1
R:R:F313	R:R:Q317	7.03	2	Yes	Yes	4	4	1	1
R:R:H321	R:R:M325	6.57	1	Yes	No	5	7	1	2
L:L:V28	R:R:A121	1.7	0	No	No	0	5	0	1
L:L:I25	R:R:P310	1.69	2	Yes	No	0	3	0	1
L:L:G24	R:R:Q54	1.64	0	No	No	0	3	0	1
L:L:G29	R:R:R301	1.5	0	No	No	0	4	0	1
R:R:L53	R:R:Q54	1.33	0	No	No	3	3	1	1
R:R:H57	R:R:L53	1.29	0	No	No	4	3	2	1
R:R:V201	R:R:Y199	1.26	0	No	No	1	4	1	1
L:L:D14	R:R:Y199	1.15	0	No	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9K26_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.53
Number of Linked Nodes	294
Number of Links	327
Number of Hubs	43
Number of Links mediated by Hubs	154
Number of Communities	10
Number of Nodes involved in Communities	50
Number of Links involved in Communities	63

Path Summary
Number Of Nodes in MetaPath	95
Number Of Links MetaPath	94
Number of Shortest Paths	82221
Length Of Smallest Path	3
Average Path Length	14.6848
Length of Longest Path	32
Minimum Path Strength	1.175
Average Path Strength	6.09235
Maximum Path Strength	20.78
Minimum Path Correlation	0.7
Average Path Correlation	0.948165
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	59.7238
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.8128
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• multi-multicellular organism process • multicellular organismal process • reproductive process • female pregnancy • multi-organism reproductive process • regulation of hormone levels • biological regulation • metabolic process • cellular process • regulation of biological quality • hormone metabolic process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • G protein-coupled receptor signaling pathway • signal transduction • cell communication • behavior • feeding behavior • membrane-bounded organelle • cell projection • cellular anatomical structure • organelle • cilium • plasma membrane bounded cell projection • cell periphery • plasma membrane • membrane • neuron projection • protein binding • binding • prolactin-releasing peptide receptor binding • signaling receptor binding • G protein-coupled receptor binding • neuropeptide receptor binding • hormone activity • molecular function activator activity • molecular function regulator activity • signaling receptor regulator activity • receptor ligand activity • signaling receptor activator activity • neuropeptide activity • neuropeptide hormone activity • reduction of food intake in response to dietary excess • response to nutrient levels • homeostatic process • eating behavior • multicellular organismal-level homeostasis • response to dietary excess • energy homeostasis • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • developmental process • multicellular organism development • anatomical structure development • autonomic nervous system development • nervous system development • system development • response to insulin • fat cell differentiation • cellular developmental process • cell differentiation • anatomical structure homeostasis • tissue homeostasis • primary metabolic process • lipid metabolic process • energy derivation by oxidation of organic compounds • energy reserve metabolic process • generation of precursor metabolites and energy • response to hexose • response to monosaccharide • response to carbohydrate • response to glucose • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • regulation of developmental process • developmental growth • growth • multicellular organism growth • regulation of multicellular organismal process • extracellular region • intracellular anatomical structure • cytoplasm • D2 dopamine receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • organelle membrane • lysosome • Golgi apparatus • endomembrane system • ciliary basal body • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • camera-type eye development • sensory system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	NH2
PDB Residues	L:L:?33
Environment Details	Open EMBL-EBI Page
Code	NH2
Name	AMINO GROUP
Synonyms
Identifier
Formula	H2 N
Molecular Weight	16.023
SMILES
PubChem	123329
Formal Charge	0
Total Atoms	3
Total Chiral Atoms	0
Total Bonds	2
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P49683
Sequence	>9K26_nogp_Chain_R L Q L V H Q L K G L I V L L Y S V V V V V G L V G N C L L V L V I A R V R R L H N V T N F L I G N L A L S D V L M C T A C V P L T L A Y A F E P R G W V F G G G L C H L V F F L Q P V T V Y V S V F T L T T I A V D R Y V V L V H P L R R R I S L R L S A Y A V L A I W A L S A V L A L P A A V H T Y H V E L K P H D V R L C E E F W G S Q E R Q R Q L Y A W G L L L V T Y L L P L L V I L L S Y V R V S V K L R N R V V P G C V T Q S Q A D W D R A R R R R T F C L L V V I V V V F A V C W L P L H V F N L L R D L D P H A I D P Y A F G L V Q L L C H W L A M S S A C Y N P F I Y A W L H D S F R E E L R K L L V Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8ZPS	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP20	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.97	2024-09-25	doi.org/10.1038/s41421-024-00724-6
	8ZPS (No Gprot)	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP20	-		2.97	2024-09-25	doi.org/10.1038/s41421-024-00724-6
	8ZPT	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP20	-	chim(NtGi1-Gs-CtGq)/β1/γ2	2.96	2024-09-25	doi.org/10.1038/s41421-024-00724-6
	8ZPT (No Gprot)	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP20	-		2.96	2024-09-25	doi.org/10.1038/s41421-024-00724-6
	9K26	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP31	-	Gi1/β1/γ2	3	2025-01-29	To be published
	9K26 (No Gprot)	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP31	-		3	2025-01-29	To be published
	9K27	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP31	-	chim(NtGi1-Gq)/β1/γ2	2.68	2025-01-29	To be published
	9K27 (No Gprot)	A	Peptide	Prolactin-releasing peptide	PrRP	Homo sapiens	PrRP31	-		2.68	2025-01-29	To be published

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Download 9K26_nogp.zip

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