psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P2	L:L:V1	5.3	No	No	0	0	0
2	L:L:P2	R:R:W204	12.16	No	Yes	0	0	3
3	L:L:L4	L:L:P5	3.28	No	No	0	0	0
4	L:L:L4	R:R:I293	2.85	No	No	0	0	4
5	L:L:L4	R:R:T307	2.95	No	No	0	0	4
6	L:L:P5	R:R:N104	3.26	No	No	0	0	4
7	L:L:P5	R:R:F311	5.78	No	Yes	0	0	4
8	L:L:Q6	R:R:C203	4.58	No	Yes	0	0	9
9	L:L:F8	L:L:R7	8.55	No	No	0	0	0
10	L:L:R7	R:R:E205	5.82	No	Yes	0	0	4
11	L:L:R7	R:R:R213	5.33	No	No	0	0	4
12	L:L:F8	R:R:W287	7.02	No	Yes	0	0	7
13	R:R:F189	R:R:L30	9.74	No	No	0	1	2
14	R:R:H188	R:R:T31	10.95	No	No	0	1	4
15	R:R:F189	R:R:F32	3.22	No	No	0	1	5
16	R:R:S33	R:R:T107	7.99	No	No	0	5	4
17	R:R:Y35	R:R:Y36	7.94	Yes	No	0	4	4
18	R:R:I106	R:R:Y35	8.46	No	Yes	0	4	4
19	R:R:M190	R:R:Y35	7.18	No	Yes	0	2	4
20	R:R:D192	R:R:Y35	6.9	Yes	Yes	0	5	4
21	R:R:H38	R:R:Q37	4.95	No	No	0	4	1
22	R:R:Q37	R:R:T107	7.09	No	No	0	1	4
23	R:R:H38	R:R:V42	8.3	No	No	0	4	4
24	R:R:H38	R:R:V308	4.15	No	No	0	4	3
25	R:R:P41	R:R:T39	5.25	No	No	0	1	3
26	R:R:T39	R:R:V42	3.17	No	No	0	3	4
27	R:R:P41	R:R:S40	3.56	No	No	0	1	2
28	R:R:F46	R:R:M45	4.98	No	No	0	5	4
29	R:R:F46	R:R:P312	5.78	No	No	0	5	3
30	R:R:I47	R:R:L105	2.85	No	Yes	0	5	5
31	R:R:A49	R:R:W316	3.89	No	Yes	0	5	5
32	R:R:L101	R:R:Y50	14.07	No	No	0	7	7
33	R:R:W316	R:R:Y50	7.72	Yes	No	0	5	7
34	R:R:L52	R:R:L55	4.15	No	No	0	5	5
35	R:R:I53	R:R:W316	11.74	No	Yes	0	7	5
36	R:R:F320	R:R:I53	3.77	No	No	0	5	7
37	R:R:I53	R:R:S323	3.1	No	No	0	7	7
38	R:R:F54	R:R:M58	11.2	No	Yes	0	6	6
39	R:R:L56	R:R:S323	6.01	No	No	0	5	7
40	R:R:C57	R:R:M58	3.24	No	Yes	0	8	6
41	R:R:C57	R:R:N61	4.72	No	Yes	0	8	9
42	R:R:C57	R:R:S323	5.16	No	No	0	8	7
43	R:R:L90	R:R:M58	2.83	No	Yes	5	7	6
44	R:R:I94	R:R:M58	2.92	No	Yes	5	5	6
45	R:R:G60	R:R:V59	3.68	No	No	0	8	5
46	R:R:L63	R:R:V59	2.98	No	No	0	6	5
47	R:R:G60	R:R:P326	4.06	No	No	0	8	9
48	R:R:D89	R:R:N61	6.73	Yes	Yes	0	9	9
49	R:R:L90	R:R:N61	6.87	No	Yes	0	7	9
50	R:R:N61	R:R:P326	4.89	Yes	No	0	9	9
51	R:R:C65	R:R:L83	3.17	No	No	0	7	6
52	R:R:F66	R:R:I67	3.77	No	No	0	4	7
53	R:R:F336	R:R:I67	5.02	Yes	No	0	8	7
54	R:R:N79	R:R:V68	4.43	Yes	No	2	8	6
55	R:R:L83	R:R:V68	5.96	No	No	0	6	6
56	R:R:F336	R:R:V68	6.55	Yes	No	2	8	6
57	R:R:H73	R:R:N71	6.38	No	No	0	5	5
58	R:R:M74	R:R:N71	7.01	No	No	0	7	5
59	R:R:M74	R:R:N79	5.61	No	Yes	0	7	8
60	R:R:M74	R:R:N335	2.8	No	No	0	7	6
61	R:R:N79	R:R:T76	5.85	Yes	No	0	8	7
62	R:R:L153	R:R:V77	8.94	No	Yes	0	6	7
63	R:R:E140	R:R:T78	14.11	No	No	0	8	8
64	R:R:F336	R:R:N79	8.46	Yes	Yes	2	8	8
65	R:R:A158	R:R:M80	4.83	No	No	0	7	5
66	R:R:L159	R:R:M80	2.83	No	No	0	3	5
67	R:R:I162	R:R:M80	4.37	No	No	0	8	5
68	R:R:A136	R:R:F81	2.77	No	No	0	7	8
69	R:R:F81	R:R:I137	3.77	No	No	0	8	9
70	R:R:I137	R:R:I82	2.94	No	No	2	9	8
71	R:R:I82	R:R:Y329	3.63	No	Yes	2	8	9
72	R:R:N84	R:R:T133	8.77	Yes	No	0	9	8
73	R:R:I162	R:R:N84	8.5	No	Yes	0	8	9
74	R:R:N84	R:R:W166	5.65	Yes	Yes	0	9	9
75	R:R:D89	R:R:L85	5.43	Yes	No	0	9	9
76	R:R:L85	R:R:T133	5.9	No	No	0	9	8
77	R:R:L134	R:R:L85	5.54	No	No	0	8	9
78	R:R:A129	R:R:S88	3.42	No	No	0	7	8
79	R:R:S130	R:R:S88	3.26	No	No	0	9	8
80	R:R:D89	R:R:S322	8.83	Yes	No	0	9	9
81	R:R:D89	R:R:N325	5.39	Yes	No	0	9	9
82	R:R:I94	R:R:L90	2.85	No	No	5	5	7
83	R:R:L91	R:R:S126	6.01	No	No	0	7	8
84	R:R:L91	R:R:W166	3.42	No	Yes	0	7	9
85	R:R:C96	R:R:V92	3.42	No	No	0	7	7
86	R:R:S322	R:R:V92	4.85	No	No	0	9	7
87	R:R:G93	R:R:M97	3.49	No	No	0	7	7
88	R:R:F95	R:R:I94	5.02	No	No	0	6	5
89	R:R:F95	R:R:V122	9.18	No	No	0	6	5
90	R:R:C96	R:R:Q123	4.58	No	No	0	7	7
91	R:R:C96	R:R:F319	2.79	No	No	0	7	7
92	R:R:M97	R:R:P98	3.35	No	No	0	7	8
93	R:R:F319	R:R:M97	8.71	No	No	0	7	7
94	R:R:H315	R:R:T100	8.21	No	No	0	6	6
95	R:R:F319	R:R:T100	6.49	No	No	0	7	6
96	R:R:L101	R:R:L105	2.77	No	Yes	0	7	5
97	R:R:D103	R:R:W109	10.05	No	Yes	0	4	8
98	R:R:N104	R:R:P312	6.52	No	No	0	4	3
99	R:R:I106	R:R:L105	2.85	No	Yes	0	4	5
100	R:R:F111	R:R:W109	14.03	No	Yes	0	7	8
101	R:R:C116	R:R:W109	3.92	Yes	Yes	1	9	8
102	R:R:C203	R:R:W109	6.53	Yes	Yes	1	9	8
103	R:R:F111	R:R:P110	8.67	No	No	0	7	3
104	R:R:F111	R:R:T115	5.19	No	No	0	7	6
105	R:R:D112	R:R:T115	5.78	No	No	0	8	6
106	R:R:K117	R:R:N113	9.79	No	No	0	7	3
107	R:R:C116	R:R:L180	4.76	Yes	Yes	1	9	5
108	R:R:C116	R:R:V182	3.42	Yes	No	0	9	5
109	R:R:C116	R:R:C203	7.28	Yes	Yes	1	9	9
110	R:R:G120	R:R:S119	3.71	No	No	0	5	5
111	R:R:Q123	R:R:S119	4.33	No	No	0	7	5
112	R:R:L121	R:R:L170	2.77	No	No	0	6	4
113	R:R:L121	R:R:M173	2.83	No	Yes	0	6	7
114	R:R:A177	R:R:L121	6.3	No	No	0	5	6
115	R:R:G124	R:R:M173	3.49	No	Yes	0	5	7
116	R:R:M125	R:R:W166	6.98	No	Yes	0	6	9
117	R:R:L170	R:R:M125	2.83	No	No	0	4	6
118	R:R:V127	R:R:W283	3.68	No	Yes	0	7	8
119	R:R:I224	R:R:S128	4.64	No	No	0	6	6
120	R:R:A129	R:R:W166	7.78	No	Yes	0	7	9
121	R:R:S130	R:R:V131	3.23	No	No	0	9	8
122	R:R:P228	R:R:V131	3.53	No	No	0	9	8
123	R:R:I165	R:R:W132	3.52	No	No	0	7	6
124	R:R:L134	R:R:N325	4.12	No	No	0	8	9
125	R:R:L134	R:R:Y329	3.52	No	Yes	0	8	9
126	R:R:P228	R:R:V135	3.53	No	No	0	9	7
127	R:R:I232	R:R:V135	3.07	No	No	0	8	7
128	R:R:I137	R:R:Y329	3.63	No	Yes	2	9	9
129	R:R:A138	R:R:M235	3.22	No	Yes	6	9	7
130	R:R:A138	R:R:Y236	5.34	No	Yes	6	9	9
131	R:R:M235	R:R:V139	3.04	Yes	No	0	7	6
132	R:R:C144	R:R:E140	4.56	No	No	0	8	8
133	R:R:R141	R:R:Y236	3.09	No	Yes	0	9	9
134	R:R:F142	R:R:V146	10.49	No	No	0	8	6
135	R:R:F142	R:R:M235	7.46	No	Yes	0	8	7
136	R:R:R143	R:R:R150	7.46	No	No	0	5	4
137	R:R:I145	R:R:I239	7.36	No	No	0	8	8
138	R:R:H147	R:R:V146	8.3	No	No	0	6	6
139	R:R:K242	R:R:V146	3.04	No	No	0	4	6
140	R:R:H147	R:R:R150	4.51	No	No	0	6	4
141	R:R:K157	R:R:T154	10.51	No	No	0	5	7
142	R:R:H223	R:R:I172	3.98	No	No	0	5	5
143	R:R:M173	R:R:Y216	3.59	Yes	Yes	0	7	6
144	R:R:L220	R:R:M173	5.65	No	Yes	0	5	7
145	R:R:P175	R:R:Y216	8.34	No	Yes	0	7	6
146	R:R:L180	R:R:S176	3	Yes	No	1	5	6
147	R:R:E205	R:R:S176	2.87	Yes	No	1	4	6
148	R:R:S176	R:R:Y216	3.82	No	Yes	0	6	6
149	R:R:T179	R:R:W207	10.92	No	Yes	0	5	5
150	R:R:C203	R:R:L180	3.17	Yes	Yes	1	9	5
151	R:R:E205	R:R:L180	5.3	Yes	Yes	1	4	5
152	R:R:V182	R:R:Y201	3.79	No	No	0	5	3
153	R:R:R184	R:R:Y201	3.09	No	No	0	1	3
154	R:R:E185	R:R:L200	7.95	No	No	0	1	1
155	R:R:E185	R:R:S202	4.31	No	No	0	1	4
156	R:R:H188	R:R:L200	5.14	No	No	0	1	1
157	R:R:D192	R:R:R194	9.53	Yes	No	0	5	4
158	R:R:D192	R:R:R196	3.57	Yes	No	4	5	6
159	R:R:D192	R:R:Y198	10.34	Yes	No	4	5	2
160	R:R:R196	R:R:S197	3.95	No	No	0	6	3
161	R:R:R196	R:R:Y198	14.4	No	No	4	6	2
162	R:R:P199	R:R:Y201	6.95	No	No	0	4	3
163	R:R:A206	R:R:W204	3.89	No	Yes	0	3	3
164	R:R:E205	R:R:W207	6.54	Yes	Yes	0	4	5
165	R:R:P208	R:R:W207	5.4	No	Yes	0	3	5
166	R:R:M212	R:R:W207	5.82	No	Yes	0	3	5
167	R:R:W207	R:R:Y216	4.82	Yes	Yes	0	5	6
168	R:R:E209	R:R:M212	6.77	No	No	0	2	3
169	R:R:G211	R:R:R214	3	No	No	0	3	3
170	R:R:D294	R:R:R213	8.34	No	No	0	5	4
171	R:R:R214	R:R:Y295	19.55	No	Yes	0	3	4
172	R:R:D294	R:R:T217	10.12	No	No	0	5	5
173	R:R:T218	R:R:Y295	3.75	No	Yes	0	4	4
174	R:R:F221	R:R:Y225	4.13	No	Yes	3	6	8
175	R:R:F221	R:R:W287	14.03	No	Yes	3	6	7
176	R:R:H223	R:R:S222	6.97	No	No	0	5	5
177	R:R:I224	R:R:W287	4.7	No	Yes	0	6	7
178	R:R:T280	R:R:Y225	3.75	No	Yes	0	5	8
179	R:R:L284	R:R:Y225	8.21	No	Yes	0	5	8
180	R:R:W287	R:R:Y225	5.79	Yes	Yes	3	7	8
181	R:R:L229	R:R:V233	2.98	No	No	0	6	4
182	R:R:F279	R:R:L229	6.09	No	No	0	9	6
183	R:R:L229	R:R:T280	7.37	No	No	0	6	5
184	R:R:I232	R:R:Y236	3.63	No	Yes	0	8	9
185	R:R:M235	R:R:Y236	5.99	Yes	Yes	6	7	9
186	R:R:L272	R:R:Y236	5.86	No	Yes	0	8	9
187	R:R:V275	R:R:Y236	5.05	No	Yes	0	8	9
188	R:R:I239	R:R:L243	2.85	No	No	0	8	8
189	R:R:I239	R:R:L272	4.28	No	No	0	8	8
190	R:R:K242	R:R:Q245	4.07	No	No	0	4	4
191	R:R:L243	R:R:R265	6.07	No	No	0	8	6
192	R:R:R263	R:R:R264	6.4	No	No	0	3	5
193	R:R:R267	R:R:V268	6.54	No	No	0	7	8
194	R:R:M271	R:R:R267	7.44	No	No	0	8	7
195	R:R:L272	R:R:V268	2.98	No	No	0	8	8
196	R:R:M271	R:R:M274	2.89	No	No	0	8	6
197	R:R:F332	R:R:M271	4.98	No	No	0	6	8
198	R:R:F278	R:R:M274	4.98	No	No	0	5	6
199	R:R:V275	R:R:Y329	3.79	No	Yes	0	8	9
200	R:R:L277	R:R:L281	6.92	No	No	0	5	6
201	R:R:F278	R:R:F320	5.36	No	No	0	5	5
202	R:R:F279	R:R:W283	8.02	No	Yes	0	9	8
203	R:R:N321	R:R:S282	8.94	No	No	0	9	8
204	R:R:W283	R:R:W287	2.81	Yes	Yes	0	8	7
205	R:R:A318	R:R:W283	5.19	No	Yes	0	7	8
206	R:R:A314	R:R:L286	3.15	No	No	0	6	7
207	R:R:A310	R:R:L289	3.15	No	No	0	5	5
208	R:R:F311	R:R:L289	4.87	Yes	No	0	4	5
209	R:R:F311	R:R:L290	4.87	Yes	No	0	4	5
210	R:R:L292	R:R:L298	9.69	No	No	0	4	2
211	R:R:L298	R:R:Q302	6.65	No	No	0	2	2
212	R:R:L298	R:R:V306	4.47	No	No	0	2	3
213	R:R:P301	R:R:S299	5.34	No	No	0	4	3
214	R:R:Q302	R:R:S299	11.55	No	No	0	2	3
215	R:R:L303	R:R:T307	2.95	No	No	0	3	4
216	R:R:H304	R:R:V308	8.3	No	No	0	2	3
217	R:R:V308	R:R:Y309	12.62	No	No	0	3	1
218	R:R:F311	R:R:H315	7.92	Yes	No	0	4	6
219	R:R:F313	R:R:L317	9.74	No	No	0	5	7
220	R:R:L317	R:R:W316	3.42	No	Yes	0	7	5
221	R:R:A324	R:R:F320	5.55	No	No	0	6	5
222	R:R:I328	R:R:Y329	3.63	No	Yes	0	8	9
223	R:R:F332	R:R:Y331	6.19	No	No	0	6	5
224	R:R:N333	R:R:N335	6.81	No	No	0	8	6
225	R:R:F336	R:R:N333	10.87	Yes	No	0	8	8
226	R:R:F46	R:R:V42	2.62	No	No	0	5	4
227	R:R:F81	R:R:V77	2.62	No	Yes	0	8	7
228	R:R:V219	R:R:Y216	2.52	No	Yes	0	3	6
229	R:R:F336	R:R:I82	2.51	Yes	No	2	8	8
230	R:R:E186	R:R:H187	2.46	No	No	0	1	3
231	R:R:F311	R:R:L286	2.44	Yes	No	0	4	7
232	R:R:T181	R:R:W204	2.43	No	Yes	0	5	3
233	R:R:T183	R:R:W204	2.43	No	Yes	0	3	3
234	R:R:F278	R:R:N321	2.42	No	No	0	5	9
235	R:R:L291	R:R:Y295	2.34	No	Yes	0	6	4
236	R:R:L305	R:R:Y309	2.34	No	No	0	2	1
237	R:R:E186	R:R:R184	2.33	No	No	0	1	1
238	R:R:F142	R:R:R238	2.14	No	No	0	8	4
239	R:R:C174	R:R:P175	1.88	No	No	0	4	7
240	R:R:A227	R:R:P228	1.87	No	No	0	5	9
241	R:R:A300	R:R:P301	1.87	No	No	0	1	4
242	R:R:G108	R:R:T107	1.82	No	No	0	4	4
243	R:R:A86	R:R:C65	1.81	No	No	0	9	7
244	R:R:G211	R:R:M212	1.75	No	No	0	3	3
245	R:R:A169	R:R:S128	1.71	No	No	0	8	6
246	R:R:C174	R:R:V178	1.71	No	No	0	4	4
247	R:R:A86	R:R:V64	1.7	No	No	0	9	9
248	R:R:A240	R:R:V269	1.7	No	No	0	5	7
249	R:R:A310	R:R:V306	1.7	No	No	0	5	3
250	R:R:A206	R:R:T179	1.68	No	No	0	3	5
251	R:R:L284	R:R:P285	1.64	No	No	0	5	9
252	R:R:A136	R:R:I165	1.62	No	No	0	7	7
253	R:R:S197	R:R:V191	1.62	No	No	0	3	4
254	R:R:S222	R:R:V219	1.62	No	No	0	5	3
255	R:R:A276	R:R:I232	1.62	No	No	0	8	8
256	R:R:S202	R:R:T183	1.6	No	No	0	4	3
257	R:R:V269	R:R:V273	1.6	No	No	0	7	5
258	R:R:A43	R:R:L105	1.58	No	Yes	0	4	5
259	R:R:H147	R:R:P148	1.53	No	No	0	6	8
260	R:R:I165	R:R:T161	1.52	No	No	0	7	6
261	R:R:F336	R:R:G330	1.51	Yes	No	0	8	6
262	R:R:L52	R:R:V48	1.49	No	No	0	5	6
263	R:R:L155	R:R:V77	1.49	No	Yes	0	4	7
264	R:R:L101	R:R:V102	1.49	No	No	0	7	4
265	R:R:L231	R:R:V234	1.49	No	No	0	6	3
266	R:R:N84	R:R:V87	1.48	Yes	No	0	9	6
267	R:R:I327	R:R:I328	1.47	No	No	0	7	8
268	R:R:N113	R:R:T181	1.46	No	No	0	3	5
269	R:R:G296	R:R:Y295	1.45	No	Yes	0	3	4
270	R:R:E140	R:R:V77	1.43	No	Yes	0	8	7
271	R:R:I172	R:R:L168	1.43	No	No	0	5	4
272	R:R:Q123	R:R:T99	1.42	No	No	0	7	6
273	R:R:K157	R:R:L153	1.41	No	No	0	5	6
274	R:R:K70	R:R:N71	1.4	No	No	0	5	5
275	R:R:L55	R:R:L56	1.38	No	No	0	5	5
276	R:R:L69	R:R:L83	1.38	No	No	0	3	6
277	R:R:A246	R:R:R265	1.38	No	No	0	5	6
278	R:R:A261	R:R:R265	1.38	No	No	0	4	6
279	R:R:R263	R:R:S262	1.32	No	No	0	3	4
280	R:R:R156	R:R:T154	1.29	No	No	0	5	7
281	R:R:E334	R:R:R338	1.16	No	No	0	4	4
282	R:R:R260	R:R:R264	1.07	No	No	0	2	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y35	7.62	4	0	4
2	R:R:M58	5.0475	4	5	6
3	R:R:N61	5.8025	4	0	9
4	R:R:V77	3.62	4	0	7
5	R:R:N79	6.0875	4	2	8
6	R:R:N84	6.1	4	0	9
7	R:R:D89	6.595	4	0	9
8	R:R:L105	2.5125	4	0	5
9	R:R:W109	8.6325	4	1	8
10	R:R:C116	4.845	4	1	9
11	R:R:W166	5.9575	4	0	9
12	R:R:M173	3.89	4	0	7
13	R:R:L180	4.0575	4	1	5
14	R:R:D192	7.585	4	4	5
15	R:R:C203	5.39	4	1	9
16	R:R:W204	5.2275	4	0	3
17	R:R:E205	5.1325	4	1	4
18	R:R:W207	6.7	5	0	5
19	R:R:Y216	4.618	5	0	6
20	R:R:Y225	5.47	4	3	8
21	R:R:M235	4.9275	4	6	7
22	R:R:Y236	4.82667	6	6	9
23	R:R:W283	4.925	4	0	8
24	R:R:W287	6.87	5	3	7
25	R:R:Y295	6.7725	4	0	4
26	R:R:F311	5.176	5	0	4
27	R:R:W316	6.6925	4	0	5
28	R:R:Y329	3.64	5	2	9
29	R:R:F336	5.82	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:P5	R:R:F311	36.9289	5.78	No	Yes	0	0	4
2	R:R:F311	R:R:H315	56.5003	7.92	Yes	No	0	4	6
3	R:R:H315	R:R:T100	57.9425	8.21	No	No	0	6	6
4	R:R:F319	R:R:T100	59.3747	6.49	No	No	0	7	6
5	R:R:C96	R:R:F319	65.0025	2.79	No	No	0	7	7
6	R:R:C96	R:R:V92	71.8104	3.42	No	No	0	7	7
7	R:R:S322	R:R:V92	73.1417	4.85	No	No	0	9	7
8	R:R:D89	R:R:S322	74.4629	8.83	Yes	No	0	9	9
9	R:R:D89	R:R:L85	86.9743	5.43	Yes	No	0	9	9
10	R:R:L85	R:R:T133	100	5.9	No	No	0	9	8
11	R:R:N84	R:R:T133	99.7882	8.77	Yes	No	0	9	8
12	R:R:N84	R:R:W166	98.3661	5.65	Yes	Yes	0	9	9
13	R:R:M125	R:R:W166	99.8437	6.98	No	Yes	0	6	9
14	R:R:L170	R:R:M125	99.4705	2.83	No	No	0	4	6
15	R:R:L121	R:R:L170	99.0872	2.77	No	No	0	6	4
16	R:R:L121	R:R:M173	98.2905	2.83	No	Yes	0	6	7
17	R:R:M173	R:R:Y216	97.0045	3.59	Yes	Yes	0	7	6
18	R:R:W207	R:R:Y216	47.0398	4.82	Yes	Yes	0	5	6
19	R:R:T179	R:R:W207	17.998	10.92	No	Yes	0	5	5
20	R:R:A206	R:R:T179	16.7776	1.68	No	No	0	3	5
21	R:R:A206	R:R:W204	15.5472	3.89	No	Yes	0	3	3
22	L:L:P5	R:R:N104	29.0217	3.26	No	No	0	0	4
23	R:R:E205	R:R:W207	28.5224	6.54	Yes	Yes	0	4	5
24	L:L:F8	L:L:R7	40.6606	8.55	No	No	0	0	0
25	L:L:R7	R:R:E205	49.2032	5.82	No	Yes	0	0	4
26	L:L:F8	R:R:W287	38.4871	7.02	No	Yes	0	0	7
27	R:R:N104	R:R:P312	27.3878	6.52	No	No	0	4	3
28	R:R:F46	R:R:P312	25.7438	5.78	No	No	0	5	3
29	R:R:F46	R:R:V42	22.4256	2.62	No	No	0	5	4
30	R:R:H38	R:R:V42	15.6682	8.3	No	No	0	4	4
31	R:R:D89	R:R:N61	62.2138	6.73	Yes	Yes	0	9	9
32	R:R:C57	R:R:N61	46.4297	4.72	No	Yes	0	8	9
33	R:R:C57	R:R:S323	43.0509	5.16	No	No	0	8	7
34	R:R:I53	R:R:S323	36.3944	3.1	No	No	0	7	7
35	R:R:I53	R:R:W316	31.0741	11.74	No	Yes	0	7	5
36	R:R:W316	R:R:Y50	25.1639	7.72	Yes	No	0	5	7
37	R:R:L101	R:R:Y50	23.6611	14.07	No	No	0	7	7
38	R:R:L101	R:R:L105	20.6253	2.77	No	Yes	0	7	5
39	R:R:I106	R:R:L105	15.996	2.85	No	Yes	0	4	5
40	R:R:I106	R:R:Y35	14.4327	8.46	No	Yes	0	4	4
41	R:R:F320	R:R:I53	11.8709	3.77	No	No	0	5	7
42	R:R:L134	R:R:L85	67.3222	5.54	No	No	0	8	9
43	R:R:L134	R:R:Y329	92.8089	3.52	No	Yes	0	8	9
44	R:R:I82	R:R:Y329	33.182	3.63	No	Yes	2	8	9
45	R:R:F336	R:R:I82	32.9148	2.51	Yes	No	2	8	8
46	R:R:F336	R:R:V68	11.1599	6.55	Yes	No	2	8	6
47	R:R:F336	R:R:N79	11.1044	8.46	Yes	Yes	2	8	8
48	R:R:I137	R:R:Y329	25.9556	3.63	No	Yes	2	9	9
49	R:R:F81	R:R:I137	25.6178	3.77	No	No	0	8	9
50	R:R:F81	R:R:V77	16.6667	2.62	No	Yes	0	8	7
51	R:R:D89	R:R:N325	28.0988	5.39	Yes	No	0	9	9
52	R:R:L134	R:R:N325	27.9778	4.12	No	No	0	8	9
53	R:R:C116	R:R:L180	16.0666	4.76	Yes	Yes	1	9	5
54	R:R:F111	R:R:W109	10.1815	14.03	No	Yes	0	7	8
55	R:R:W283	R:R:W287	13.7973	2.81	Yes	Yes	0	8	7
56	R:R:V275	R:R:Y329	42.8341	3.79	No	Yes	0	8	9
57	R:R:V275	R:R:Y236	41.4221	5.05	No	Yes	0	8	9
58	R:R:M235	R:R:Y236	19.1881	5.99	Yes	Yes	6	7	9
59	R:R:F142	R:R:M235	15.8346	7.46	No	Yes	0	8	7
60	R:R:F142	R:R:V146	12.3853	10.49	No	No	0	8	6
61	R:R:L272	R:R:Y236	19.9193	5.86	No	Yes	0	8	9
62	R:R:I239	R:R:L272	10.3076	4.28	No	No	0	8	8
63	R:R:E205	R:R:S176	23.1921	2.87	Yes	No	1	4	6
64	R:R:S176	R:R:Y216	45.885	3.82	No	Yes	0	6	6
65	R:R:M212	R:R:W207	10.5245	5.82	No	Yes	0	3	5
66	R:R:W287	R:R:Y225	13.7771	5.79	Yes	Yes	3	7	8
67	R:R:L272	R:R:V268	10.4236	2.98	No	No	0	8	8
68	R:R:F311	R:R:L289	15.7892	4.87	Yes	No	0	4	5
69	R:R:A310	R:R:L289	14.0746	3.15	No	No	0	5	5
70	R:R:A310	R:R:V306	12.35	1.7	No	No	0	5	3
71	R:R:L298	R:R:V306	10.6152	4.47	No	No	0	2	3
72	R:R:L180	R:R:S176	21.9264	3	Yes	No	1	5	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:P2	R:R:W204	12.16	0	No	Yes	0	3	0	1
L:L:L4	R:R:I293	2.85	0	No	No	0	4	0	1
L:L:L4	R:R:T307	2.95	0	No	No	0	4	0	1
L:L:P5	R:R:N104	3.26	0	No	No	0	4	0	1
L:L:P5	R:R:F311	5.78	0	No	Yes	0	4	0	1
L:L:Q6	R:R:C203	4.58	0	No	Yes	0	9	0	1
L:L:R7	R:R:E205	5.82	0	No	Yes	0	4	0	1
L:L:R7	R:R:R213	5.33	0	No	No	0	4	0	1
L:L:F8	R:R:W287	7.02	0	No	Yes	0	7	0	1
R:R:N104	R:R:P312	6.52	0	No	No	4	3	1	2
R:R:C116	R:R:W109	3.92	1	Yes	Yes	9	8	2	2
R:R:C203	R:R:W109	6.53	1	Yes	Yes	9	8	1	2
R:R:C116	R:R:L180	4.76	1	Yes	Yes	9	5	2	2
R:R:C116	R:R:C203	7.28	1	Yes	Yes	9	9	2	1
R:R:L180	R:R:S176	3	1	Yes	No	5	6	2	2
R:R:E205	R:R:S176	2.87	1	Yes	No	4	6	1	2
R:R:C203	R:R:L180	3.17	1	Yes	Yes	9	5	1	2
R:R:E205	R:R:L180	5.3	1	Yes	Yes	4	5	1	2
R:R:A206	R:R:W204	3.89	0	No	Yes	3	3	2	1
R:R:E205	R:R:W207	6.54	1	Yes	Yes	4	5	1	2
R:R:D294	R:R:R213	8.34	0	No	No	5	4	2	1
R:R:F221	R:R:Y225	4.13	3	No	Yes	6	8	2	2
R:R:F221	R:R:W287	14.03	3	No	Yes	6	7	2	1
R:R:I224	R:R:W287	4.7	0	No	Yes	6	7	2	1
R:R:W287	R:R:Y225	5.79	3	Yes	Yes	7	8	1	2
R:R:W283	R:R:W287	2.81	0	Yes	Yes	8	7	2	1
R:R:F311	R:R:L289	4.87	0	Yes	No	4	5	1	2
R:R:F311	R:R:L290	4.87	0	Yes	No	4	5	1	2
R:R:L303	R:R:T307	2.95	0	No	No	3	4	2	1
R:R:F311	R:R:H315	7.92	0	Yes	No	4	6	1	2
R:R:F311	R:R:L286	2.44	0	Yes	No	4	7	1	2
R:R:T181	R:R:W204	2.43	0	No	Yes	5	3	2	1
R:R:T183	R:R:W204	2.43	0	No	Yes	3	3	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9VI9_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.77
Number of Linked Nodes	273
Number of Links	282
Number of Hubs	29
Number of Links mediated by Hubs	109
Number of Communities	6
Number of Nodes involved in Communities	24
Number of Links involved in Communities	27

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	44962
Length Of Smallest Path	3
Average Path Length	16.6805
Length of Longest Path	36
Minimum Path Strength	1.38
Average Path Strength	5.20861
Maximum Path Strength	12.04
Minimum Path Correlation	0.7
Average Path Correlation	0.929657
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	46.4338
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	32.5489
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9GZQ6
Sequence	>9VI9_nogp_Chain_R N L T F S S Y Y Q H T S P V A A M F I V A Y A L I F L L C M V G N T L V C F I V L K N R H M H T V T N M F I L N L A V S D L L V G I F C M P T T L V D N L I T G W P F D N A T C K M S G L V Q G M S V S A S V T L V A I A V E R F R C I V H P F R E K L T L R K A L V T I A V I W A L A L L I M C P S A V T L T V T R E E H H F M V D A R N R S Y P L Y S C W E A W P E K G M R R V Y T T V L F S H I Y L A P L A L I V V M Y A R I A R K L C Q A P R A S R R R A R V V H M L V M V A L F F T L S W L P L W A L L L L I D Y G Q L S A P Q L H L V T V Y A F P F A H W L A F F N S S A N P I I Y G Y F N E N F R R W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9M0R	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-	Gi1/β1/γ2	2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M0R (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-		2.47	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-	Gi1/β1/γ2	2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9M2F (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-FF	-		2.93	2025-07-23	doi.org/10.1016/j.celrep.2025.116160
	9VI9	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	RFRP-3	-	Gi1/β1/γ2	3.02	2025-12-03	10.1093/procel/pwaf090
	9VI9 (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	RFRP-3	-		3.02	2025-12-03	10.1093/procel/pwaf090
	9VIF	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-	Gi1/β1/γ2	3.19	2025-12-03	10.1093/procel/pwaf090
	9VIF (No Gprot)	A	Peptide	Neuropeptide FF	NPFF1	Homo sapiens	Neuropeptide-VF	-		3.19	2025-12-03	10.1093/procel/pwaf090

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 9VI9_nogp.zip

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