Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

All columns can be sorted in ascending/descending alphabetical order, clicking on the corresponding column header.

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.


Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1Node2LinkStrengthCommIsNode1Hub?IsNode2Hub?Node1ConsNode2ConsNode1ShellNode2Shell
1x392x608.1951YesYes7621
2x533x359.060YesNo6822
2x533x363.7350YesYes6721
2x537x428.2550YesYes6721
2x602x633.3751YesNo6512
2x60Lig9.421YesYes6010
2x63E1.Y9311.910NoNo5421
2x63E2.Q1809.020NoYes5222
2x67E1.Y934.60NoNo6421
E1.Y93Lig7.4551NoYes4010
3x323x333.141NoYes6511
3x323x352.831NoNo6812
3x32Lig17.1851NoYes6010
3x333x372.5751YesYes5612
3x334x619.8351YesNo5412
3x33E2x522.491YesYes5511
3x33Lig11.6151YesYes5010
3x363x373.5951YesYes7612
3x366x484.071YesYes7912
3x36Lig4.9751YesYes7010
4x614x653.9250NoYes4522
4x65E2x522.480YesYes5521
E2.L173E2x512.930NoYes3421
E2.E174E2.N1756.571NoNo2212
E2.E174Lig2.3251NoYes2010
E2.Q180E2x519.0151YesYes2421
E2x51Lig5.6451YesYes4010
E2x52Lig8.241YesYes5010
5x36E2.Y1856.1751YesNo4522
6x486x526.3451YesYes9822
6x487x415.561YesNo9722
6x516x524.91YesYes6812
6x516x5513.7351YesNo6511
6x517x343.611YesYes6411
6x517x413.181YesNo6712
6x51Lig9.661YesYes6010
6x547x343.2750NoYes4421
6x557x344.341NoYes5411
6x55Lig5.7051NoYes5010
6x586x592.3951YesNo4512
6x587x319.581YesNo4412
6x58Lig8.911YesYes4010
7x28Lig6.681NoYes3010
7x347x354.331YesNo4411
7x34Lig12.8151YesYes4010
7x35Lig4.811NoYes4010
7x387x429.9851NoYes5711
7x38Lig2.6451NoYes5010
7x42Lig3.941YesYes7010
1x397x384.371YesNo7521
1x397x423.971YesYes7721
2x603x284.941YesNo6512
4x64E2x522.8250NoYes5521
E2.T169E2x512.4950NoYes4421
E2.Y185E2x524.191NoYes5521
5x36E2x524.7351YesYes4521
6x586x625.0851YesNo4412
1x427x421.8950NoYes7721
7x287x291.221NoNo3112
LigNT.G280.751YesNo0301
7x36NT.G280.7250NoNo5321

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Consensus Members
Id Members
7W0P 7W0P-Apelin-Elabela-Gi1/&β;1/&γ;2
7W0M 7W0M-Apelin-PubChem 122701908-Gi1/&β;1/&γ;2
Net Summary
Imin 2.26
Number of Linked Nodes 284
Number of Links 333
Number of Hubs 42
Number of Links mediated by Hubs 166
Number of Communities 3
Number of Nodes involved in Communities 62
Number of Links involved in Communities 90
Path Summary
Number Of Nodes in MetaPath 72
Number Of Links MetaPath 71
Number of Shortest Paths 64434
Length Of Smallest Path 3
Average Path Length 11.1588
Length of Longest Path 25
Minimum Path Strength 0.6975
Average Path Strength 4.5617
Maximum Path Strength 12.6025
Minimum Path Correlation 0.7
Average Path Correlation 0.934002
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5.88235
Average % Of Corr. Nodes 55.674
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.139
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .

This network is also present in following consensuses:
IdComponents
peptide_onopioid_on
angiotensin_on
bombesin_on
cck_on
endothelin_on
ghrelin_on
npy_on
nts_on
orexin_on
vasopressin-ot_on
tachykinin_on
sst_on
relaxin_on
trh_on
nmur_on
motilin_on
melanocortin_on
galanin_on
fpr-alx_on
compl-peptide_on
bradykinin_on
apelin_on



You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download apelin_on.zip



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