Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7DFL | A | Amine | Histamine | H1 | Homo sapiens | Histamine | - | chim(NtGi1L-Gq)/Beta1/Gamma2 | 3.3 | 2021-03-31 | 10.1038/s41467-021-22427-2 |
![](/psngpcr/ligands/HSM/HSM_7DFL_L_L_1.png)
A 2D representation of the interactions of HSM in 7DFL colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V76 | R:R:V80 | 3.21 | 1 | No | No | 9 | 9 | 2 | 2 | R:R:V76 | R:R:Y458 | 3.79 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:D107 | R:R:V80 | 13.15 | 1 | Yes | No | 9 | 9 | 1 | 2 | R:R:V80 | R:R:Y458 | 5.05 | 1 | No | Yes | 9 | 9 | 2 | 1 | R:R:M81 | R:R:W455 | 4.65 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:M81 | R:R:Y458 | 3.59 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:I454 | R:R:N84 | 7.08 | 1 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:N84 | R:R:W455 | 3.39 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:N84 | R:R:Y458 | 11.63 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:D107 | R:R:S111 | 4.42 | 1 | Yes | No | 9 | 9 | 1 | 1 | R:R:D107 | R:R:Y458 | 13.79 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:D107 | 9.84 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:W158 | R:R:Y108 | 15.43 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:I162 | R:R:Y108 | 3.63 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:F184 | R:R:Y108 | 6.19 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:Y108 | R:R:Y431 | 2.98 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:Y108 | 19.12 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:S111 | R:R:W428 | 4.94 | 1 | No | Yes | 9 | 9 | 1 | 2 | L:L:?1 | R:R:S111 | 6.8 | 1 | Yes | No | 0 | 9 | 0 | 1 | R:R:F116 | R:R:T112 | 6.49 | 1 | No | Yes | 8 | 9 | 2 | 1 | R:R:S155 | R:R:T112 | 3.2 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:T112 | R:R:W158 | 9.7 | 1 | Yes | Yes | 9 | 8 | 1 | 2 | R:R:N198 | R:R:T112 | 10.24 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:T112 | 5.34 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F116 | R:R:N198 | 7.25 | 1 | No | Yes | 8 | 9 | 2 | 1 | R:R:F184 | R:R:W158 | 4.01 | 1 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:F432 | R:R:N198 | 6.04 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | L:L:?1 | R:R:N198 | 7.46 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F199 | R:R:W428 | 3.01 | 1 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:F199 | R:R:F432 | 23.58 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:W428 | R:R:Y431 | 2.89 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F432 | R:R:W428 | 4.01 | 1 | Yes | Yes | 9 | 9 | 1 | 2 | R:R:F432 | R:R:Y431 | 6.19 | 1 | Yes | Yes | 9 | 9 | 1 | 1 | R:R:T453 | R:R:Y431 | 4.99 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:I454 | R:R:Y431 | 4.84 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | L:L:?1 | R:R:Y431 | 23.36 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F432 | R:R:F435 | 8.57 | 1 | Yes | No | 9 | 8 | 1 | 2 | L:L:?1 | R:R:F432 | 8.83 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:I454 | R:R:W455 | 3.52 | 1 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:I454 | R:R:Y458 | 9.67 | 1 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:W455 | R:R:Y458 | 3.86 | 1 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:Y458 | 4.25 | 1 | Yes | Yes | 0 | 9 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 10.62 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 17.00 | Average Links In Shell | 42.00 | Average Links Mediated by Hubs In Shell | 41.00 |
| ![](/psngpcr/ligands/HSM/HSM_7DFL_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/HSM/HSM_7DFL_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 7YFC | A | Amine | Histamine | H4 | Homo Sapiens | Histamine | - | chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 | 3 | 2023-10-25 | 10.1038/s41467-023-42260-z |
![](/psngpcr/ligands/HSM/HSM_7YFC_L_L_1.png)
A 2D representation of the interactions of HSM in 7YFC colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:D94 | R:R:S68 | 5.89 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:S68 | R:R:W348 | 7.41 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:C98 | R:R:D94 | 3.11 | 2 | No | Yes | 8 | 8 | 1 | 1 | R:R:D94 | R:R:F344 | 2.39 | 2 | Yes | Yes | 8 | 6 | 1 | 1 | R:R:D94 | R:R:W348 | 3.35 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | L:L:?1 | R:R:D94 | 11.06 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:N147 | R:R:Y95 | 11.63 | 0 | No | No | 8 | 8 | 2 | 1 | R:R:P166 | R:R:Y95 | 5.56 | 2 | Yes | No | 7 | 8 | 2 | 1 | L:L:?1 | R:R:Y95 | 30.8 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:C98 | R:R:W316 | 2.61 | 2 | No | Yes | 8 | 9 | 1 | 1 | L:L:?1 | R:R:C98 | 5.75 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:E182 | R:R:T99 | 4.23 | 2 | No | No | 8 | 8 | 1 | 2 | R:R:F312 | R:R:V102 | 5.24 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:V102 | R:R:W316 | 7.36 | 2 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:E182 | R:R:W316 | 9.81 | 2 | No | Yes | 8 | 9 | 1 | 1 | L:L:?1 | R:R:E182 | 8.4 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:F312 | R:R:W316 | 10.02 | 2 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:F312 | R:R:N350 | 2.42 | 2 | Yes | Yes | 9 | 9 | 2 | 2 | R:R:Q347 | R:R:W316 | 17.52 | 2 | No | Yes | 8 | 9 | 1 | 1 | R:R:N350 | R:R:W316 | 6.78 | 2 | Yes | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W316 | 3.1 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:T323 | R:R:Y319 | 7.49 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:Y319 | R:R:Y340 | 10.92 | 2 | Yes | Yes | 7 | 5 | 1 | 2 | R:R:A343 | R:R:Y319 | 2.67 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:F344 | R:R:Y319 | 7.22 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:Q347 | R:R:Y319 | 6.76 | 2 | No | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:Y319 | 4.25 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:T323 | R:R:Y340 | 6.24 | 2 | Yes | Yes | 7 | 5 | 2 | 2 | R:R:F344 | R:R:W348 | 5.01 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | L:L:?1 | R:R:F344 | 6.62 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | L:L:?1 | R:R:Q347 | 16.88 | 2 | Yes | No | 0 | 8 | 0 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 10.86 | Average Nodes In Shell | 20.00 | Average Hubs In Shell | 13.00 | Average Links In Shell | 31.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/HSM/HSM_7YFC_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/HSM/HSM_7YFC_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8HN8 | A | Amine | Histamine | H4 | Homo Sapiens | Histamine | - | Gi1/Beta1/Gamma2 | 3 | 2023-12-20 | To be published |
![](/psngpcr/ligands/HSM/HSM_8HN8_L_L_1.png)
A 2D representation of the interactions of HSM in 8HN8 colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:S68 | R:R:V64 | 3.23 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:V64 | R:R:W348 | 2.45 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:S68 | R:R:W90 | 2.47 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:D94 | R:R:S68 | 7.36 | 2 | Yes | Yes | 8 | 8 | 1 | 2 | R:R:S68 | R:R:W348 | 6.18 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:I69 | R:R:W345 | 5.87 | 2 | Yes | Yes | 8 | 8 | 2 | 2 | R:R:I69 | R:R:W348 | 3.52 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:W90 | R:R:Y72 | 10.61 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:F344 | R:R:Y72 | 12.38 | 2 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:W345 | R:R:Y72 | 4.82 | 2 | Yes | Yes | 8 | 7 | 2 | 2 | R:R:W348 | R:R:Y72 | 5.79 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:W348 | R:R:W90 | 1.87 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:C98 | R:R:D94 | 3.11 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | R:R:D94 | R:R:W348 | 12.28 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:D94 | 8.61 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:N147 | R:R:Y95 | 15.12 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | R:R:I151 | R:R:Y95 | 4.84 | 2 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:P166 | R:R:Y95 | 6.95 | 2 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:F169 | R:R:Y95 | 3.09 | 2 | Yes | Yes | 6 | 8 | 2 | 1 | L:L:?1 | R:R:Y95 | 12.74 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:C98 | R:R:W316 | 2.61 | 2 | Yes | Yes | 8 | 9 | 1 | 1 | R:R:C98 | R:R:W348 | 2.61 | 2 | Yes | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:C98 | 7.19 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:F312 | R:R:V102 | 7.87 | 2 | Yes | Yes | 9 | 8 | 2 | 2 | R:R:V102 | R:R:W316 | 6.13 | 2 | Yes | Yes | 8 | 9 | 2 | 1 | R:R:I151 | R:R:N147 | 4.25 | 2 | Yes | Yes | 7 | 8 | 2 | 2 | R:R:E182 | R:R:N147 | 2.63 | 2 | No | Yes | 8 | 8 | 1 | 2 | R:R:I151 | R:R:P166 | 3.39 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:F169 | R:R:P166 | 13 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F169 | R:R:Y319 | 2.06 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:E182 | R:R:W316 | 8.72 | 2 | No | Yes | 8 | 9 | 1 | 1 | L:L:?1 | R:R:E182 | 2.4 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:F183 | R:R:W316 | 3.01 | 0 | No | Yes | 9 | 9 | 2 | 1 | R:R:F312 | R:R:W316 | 8.02 | 2 | Yes | Yes | 9 | 9 | 2 | 1 | R:R:Q347 | R:R:W316 | 12.05 | 2 | Yes | Yes | 8 | 9 | 1 | 1 | R:R:N350 | R:R:W316 | 6.78 | 0 | No | Yes | 9 | 9 | 2 | 1 | L:L:?1 | R:R:W316 | 2.06 | 2 | Yes | Yes | 0 | 9 | 0 | 1 | R:R:F344 | R:R:Y319 | 10.32 | 2 | Yes | Yes | 6 | 7 | 1 | 2 | R:R:Q347 | R:R:Y319 | 11.27 | 2 | Yes | Yes | 8 | 7 | 1 | 2 | R:R:F344 | R:R:W345 | 2 | 2 | Yes | Yes | 6 | 8 | 1 | 2 | R:R:F344 | R:R:W348 | 8.02 | 2 | Yes | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:F344 | 16.55 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:W345 | R:R:W348 | 13.12 | 2 | Yes | Yes | 8 | 8 | 2 | 1 | L:L:?1 | R:R:Q347 | 15.67 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | R:R:W348 | 11.35 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:Q347 | R:R:S320 | 1.44 | 2 | Yes | No | 8 | 8 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 8.00 | Average Number Of Links With An Hub | 7.00 | Average Interaction Strength | 9.57 | Average Nodes In Shell | 25.00 | Average Hubs In Shell | 21.00 | Average Links In Shell | 46.00 | Average Links Mediated by Hubs In Shell | 46.00 |
| ![](/psngpcr/ligands/HSM/HSM_8HN8_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/HSM/HSM_8HN8_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8JXT | A | Amine | Histamine | H4 | Homo Sapiens | Histamine | PO4 | Gi1/Beta1/Gamma2 | 3.07 | 2024-03-20 | 10.1038/s41467-024-46840-5 |
![](/psngpcr/ligands/HSM/HSM_8JXT_L_L_1.png)
A 2D representation of the interactions of HSM in 8JXT colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V64 | R:R:W348 | 2.45 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:D94 | R:R:S68 | 5.89 | 2 | No | No | 8 | 8 | 1 | 2 | R:R:S68 | R:R:W348 | 4.94 | 2 | No | Yes | 8 | 8 | 2 | 1 | R:R:I69 | R:R:W348 | 2.35 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:D94 | R:R:W348 | 12.28 | 2 | No | Yes | 8 | 8 | 1 | 1 | L:L:?1 | R:R:D94 | 11.06 | 2 | Yes | No | 0 | 8 | 0 | 1 | R:R:N147 | R:R:Y95 | 15.12 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:I151 | R:R:Y95 | 2.42 | 0 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:P166 | R:R:Y95 | 6.95 | 2 | Yes | Yes | 7 | 8 | 2 | 1 | R:R:F168 | R:R:Y95 | 3.09 | 2 | Yes | Yes | 6 | 8 | 2 | 1 | L:L:?1 | R:R:Y95 | 12.74 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | R:R:Y95 | W:W:?1 | 8.09 | 2 | Yes | Yes | 8 | 0 | 1 | 1 | R:R:C98 | R:R:W316 | 2.61 | 0 | No | Yes | 8 | 9 | 2 | 2 | R:R:C98 | R:R:W348 | 2.61 | 0 | No | Yes | 8 | 8 | 2 | 1 | R:R:F168 | R:R:P166 | 10.11 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F169 | R:R:P166 | 4.33 | 2 | Yes | Yes | 6 | 7 | 2 | 2 | R:R:F168 | R:R:F169 | 4.29 | 2 | Yes | Yes | 6 | 6 | 2 | 2 | R:R:F169 | R:R:Y319 | 2.06 | 2 | Yes | Yes | 6 | 7 | 2 | 1 | R:R:E182 | R:R:W316 | 10.9 | 2 | Yes | Yes | 8 | 9 | 2 | 2 | R:R:E182 | W:W:?1 | 18.29 | 2 | Yes | Yes | 8 | 0 | 2 | 1 | R:R:Q347 | R:R:W316 | 24.09 | 2 | No | Yes | 8 | 9 | 1 | 2 | R:R:W316 | W:W:?1 | 6.55 | 2 | Yes | Yes | 9 | 0 | 2 | 1 | R:R:T323 | R:R:Y319 | 8.74 | 0 | No | Yes | 7 | 7 | 2 | 1 | R:R:Y319 | R:R:Y340 | 4.96 | 2 | Yes | No | 7 | 5 | 1 | 2 | R:R:A343 | R:R:Y319 | 2.67 | 0 | No | Yes | 5 | 7 | 2 | 1 | R:R:F344 | R:R:Y319 | 10.32 | 2 | No | Yes | 6 | 7 | 1 | 1 | R:R:Q347 | R:R:Y319 | 3.38 | 2 | No | Yes | 8 | 7 | 1 | 1 | L:L:?1 | R:R:Y319 | 4.25 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F344 | R:R:W348 | 2 | 2 | No | Yes | 6 | 8 | 1 | 1 | L:L:?1 | R:R:F344 | 20.96 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:W345 | R:R:W348 | 6.56 | 0 | No | Yes | 8 | 8 | 2 | 1 | L:L:?1 | R:R:Q347 | 6.03 | 2 | Yes | No | 0 | 8 | 0 | 1 | L:L:?1 | R:R:W348 | 11.35 | 2 | Yes | Yes | 0 | 8 | 0 | 1 | L:L:?1 | W:W:?1 | 4.33 | 2 | Yes | Yes | 0 | 0 | 0 | 1 | R:R:S320 | W:W:?1 | 1.73 | 0 | No | Yes | 8 | 0 | 2 | 1 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 4.00 | Average Interaction Strength | 10.10 | Average Nodes In Shell | 24.00 | Average Hubs In Shell | 11.00 | Average Links In Shell | 35.00 | Average Links Mediated by Hubs In Shell | 34.00 |
| ![](/psngpcr/ligands/HSM/HSM_8JXT_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/HSM/HSM_8JXT_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|
Show | PDB | Class | SubFamily | Type | SubType | Species | Orthosteric Ligand | Other Ligand(s) | Protein Partners | Resolution | Date | DOI |
| 8POK | A | Amine | Histamine | H2 | Homo Sapiens | Histamine | - | Gs/Beta1/Gamma2 | 3.4 | 2024-03-06 | 10.1038/s41467-024-46096-z |
![](/psngpcr/ligands/HSM/HSM_8POK_L_L_1.png)
A 2D representation of the interactions of HSM in 8POK colored according to ConSurf Conservation Grade (See documentation):
(Click to enlarge 🔍) | Node1 | Node2 | LinkStrength | Comm | IsNode1Hub? | IsNode2Hub? | Node1Cons | Node2Cons | Node1Shell | Node2Shell | R:R:V71 | R:R:Y94 | 2.52 | 2 | No | Yes | 6 | 6 | 2 | 2 | R:R:D98 | R:R:V71 | 5.84 | 2 | Yes | No | 5 | 6 | 1 | 2 | R:R:D98 | R:R:Y94 | 2.3 | 2 | Yes | Yes | 5 | 6 | 1 | 2 | R:R:D98 | R:R:Y278 | 4.6 | 2 | Yes | No | 5 | 6 | 1 | 2 | L:L:?1 | R:R:D98 | 8.61 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | R:R:S150 | R:R:V99 | 3.23 | 9 | No | No | 6 | 4 | 2 | 1 | R:R:V176 | R:R:V99 | 3.21 | 0 | No | No | 4 | 4 | 2 | 1 | L:L:?1 | R:R:V99 | 5.4 | 2 | Yes | No | 0 | 4 | 0 | 1 | R:R:C102 | R:R:W247 | 5.22 | 2 | No | Yes | 6 | 7 | 1 | 1 | L:L:?1 | R:R:C102 | 2.88 | 2 | Yes | No | 0 | 6 | 0 | 1 | R:R:F191 | R:R:I106 | 2.51 | 2 | Yes | Yes | 7 | 7 | 2 | 2 | R:R:I106 | R:R:W247 | 2.35 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:D186 | R:R:Y182 | 6.9 | 2 | Yes | Yes | 3 | 6 | 1 | 2 | R:R:F254 | R:R:Y182 | 2.06 | 2 | Yes | Yes | 4 | 6 | 2 | 2 | R:R:D186 | R:R:T190 | 7.23 | 2 | Yes | No | 3 | 5 | 1 | 2 | R:R:D186 | R:R:F251 | 4.78 | 2 | Yes | Yes | 3 | 6 | 1 | 1 | R:R:D186 | R:R:F254 | 2.39 | 2 | Yes | Yes | 3 | 4 | 1 | 2 | L:L:?1 | R:R:D186 | 2.46 | 2 | Yes | Yes | 0 | 3 | 0 | 1 | R:R:F191 | R:R:W247 | 3.01 | 2 | Yes | Yes | 7 | 7 | 2 | 1 | R:R:F191 | R:R:F251 | 11.79 | 2 | Yes | Yes | 7 | 6 | 2 | 1 | R:R:W247 | R:R:Y250 | 4.82 | 2 | Yes | Yes | 7 | 5 | 1 | 1 | R:R:F251 | R:R:W247 | 4.01 | 2 | Yes | Yes | 6 | 7 | 1 | 1 | R:R:G277 | R:R:W247 | 2.81 | 0 | No | Yes | 6 | 7 | 2 | 1 | R:R:N280 | R:R:W247 | 6.78 | 0 | Yes | Yes | 9 | 7 | 2 | 1 | L:L:?1 | R:R:W247 | 2.06 | 2 | Yes | Yes | 0 | 7 | 0 | 1 | R:R:F251 | R:R:Y250 | 4.13 | 2 | Yes | Yes | 6 | 5 | 1 | 1 | R:R:F254 | R:R:Y250 | 5.16 | 2 | Yes | Yes | 4 | 5 | 2 | 1 | R:R:L274 | R:R:Y250 | 2.34 | 0 | No | Yes | 4 | 5 | 2 | 1 | L:L:?1 | R:R:Y250 | 20.18 | 2 | Yes | Yes | 0 | 5 | 0 | 1 | L:L:?1 | R:R:F251 | 3.31 | 2 | Yes | Yes | 0 | 6 | 0 | 1 | R:R:L274 | R:R:Y278 | 4.69 | 0 | No | No | 4 | 6 | 2 | 2 | R:R:F251 | R:R:G187 | 1.51 | 2 | Yes | No | 6 | 4 | 1 | 2 | |
Statistics | Value |
---|
Average Number Of Links | 7.00 | Average Number Of Links With An Hub | 5.00 | Average Interaction Strength | 6.41 | Average Nodes In Shell | 22.00 | Average Hubs In Shell | 12.00 | Average Links In Shell | 32.00 | Average Links Mediated by Hubs In Shell | 29.00 |
| ![](/psngpcr/ligands/HSM/HSM_8POK_L_L_1_res_stats.svg) Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍) | ![](/psngpcr/ligands/HSM/HSM_8POK_L_L_1_pos_stats.svg) Location of the nodes interacting with this ligand (click to enlarge 🔍) |
|