CodeHSM
NameHistamine
Synonyms1H-Imidazole-4-ethanamine
Identifier
FormulaC5 H9 N3
Molecular Weight111.145
SMILES
PubChem774
Formal Charge0
Total Atoms17
Total Chiral Atoms0
Total Bonds17
Total Aromatic Bonds5
Networks31
 missing image

This ligand is also present in the following 31 networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7DFL A Amine Histamine H1 Homo Sapiens Histamine - chim(NtGi1L-Gq)/Beta1/Gamma2 3.3 2021-03-31 doi.org/10.1038/s41467-021-22427-2

A 2D representation of the interactions of HSM in 7DFL
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V76 R:R:V80 3.21 1 No No 9 9 2 2
R:R:V76 R:R:Y458 3.79 1 No Yes 9 9 2 1
R:R:D107 R:R:V80 13.15 1 Yes No 9 9 1 2
R:R:V80 R:R:Y458 5.05 1 No Yes 9 9 2 1
R:R:M81 R:R:W455 4.65 1 Yes Yes 9 9 2 2
R:R:M81 R:R:Y458 3.59 1 Yes Yes 9 9 2 1
R:R:I454 R:R:N84 7.08 1 Yes Yes 8 8 2 2
R:R:N84 R:R:W455 3.39 1 Yes Yes 8 9 2 2
R:R:N84 R:R:Y458 11.63 1 Yes Yes 8 9 2 1
R:R:D107 R:R:S111 4.42 1 Yes No 9 9 1 1
R:R:D107 R:R:Y458 13.79 1 Yes Yes 9 9 1 1
L:L:?1 R:R:D107 9.92 1 Yes Yes 0 9 0 1
R:R:W158 R:R:Y108 15.43 1 Yes Yes 8 9 2 1
R:R:I162 R:R:Y108 3.63 0 No Yes 9 9 2 1
R:R:F184 R:R:Y108 6.19 1 Yes Yes 9 9 2 1
R:R:Y108 R:R:Y431 2.98 1 Yes Yes 9 9 1 1
L:L:?1 R:R:Y108 19.28 1 Yes Yes 0 9 0 1
R:R:S111 R:R:W428 4.94 1 No Yes 9 9 1 2
L:L:?1 R:R:S111 6.86 1 Yes No 0 9 0 1
R:R:F116 R:R:T112 6.49 1 No Yes 8 9 2 1
R:R:S155 R:R:T112 3.2 1 Yes Yes 9 9 2 1
R:R:T112 R:R:W158 9.7 1 Yes Yes 9 8 1 2
R:R:N198 R:R:T112 10.24 1 Yes Yes 9 9 1 1
L:L:?1 R:R:T112 5.39 1 Yes Yes 0 9 0 1
R:R:F116 R:R:N198 7.25 1 No Yes 8 9 2 1
R:R:F184 R:R:W158 4.01 1 Yes Yes 9 8 2 2
R:R:F432 R:R:N198 6.04 1 Yes Yes 9 9 1 1
L:L:?1 R:R:N198 7.53 1 Yes Yes 0 9 0 1
R:R:F199 R:R:W428 3.01 1 Yes Yes 9 9 2 2
R:R:F199 R:R:F432 23.58 1 Yes Yes 9 9 2 1
R:R:W428 R:R:Y431 2.89 1 Yes Yes 9 9 2 1
R:R:F432 R:R:W428 4.01 1 Yes Yes 9 9 1 2
R:R:F432 R:R:Y431 6.19 1 Yes Yes 9 9 1 1
R:R:T453 R:R:Y431 4.99 0 No Yes 9 9 2 1
R:R:I454 R:R:Y431 4.84 1 Yes Yes 8 9 2 1
L:L:?1 R:R:Y431 23.56 1 Yes Yes 0 9 0 1
R:R:F432 R:R:F435 8.57 1 Yes No 9 8 1 2
L:L:?1 R:R:F432 8.9 1 Yes Yes 0 9 0 1
R:R:I454 R:R:W455 3.52 1 Yes Yes 8 9 2 2
R:R:I454 R:R:Y458 9.67 1 Yes Yes 8 9 2 1
R:R:W455 R:R:Y458 3.86 1 Yes Yes 9 9 2 1
L:L:?1 R:R:Y458 4.28 1 Yes Yes 0 9 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.72
Average Nodes In Shell24.00
Average Hubs In Shell17.00
Average Links In Shell42.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7YFC A Amine Histamine H4 Homo Sapiens Histamine - chim(NtGi1-Gs-CtGq)/Beta1/Gamma2 3 2023-10-25 doi.org/10.1038/s41467-023-42260-z

A 2D representation of the interactions of HSM in 7YFC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:D94 R:R:S68 5.89 2 Yes Yes 8 8 1 2
R:R:S68 R:R:W348 7.41 2 Yes Yes 8 8 2 2
R:R:C98 R:R:D94 3.11 2 No Yes 8 8 1 1
R:R:D94 R:R:F344 2.39 2 Yes Yes 8 6 1 1
R:R:D94 R:R:W348 3.35 2 Yes Yes 8 8 1 2
L:L:?1 R:R:D94 11.5 2 Yes Yes 0 8 0 1
R:R:N147 R:R:Y95 11.63 0 No No 8 8 2 1
R:R:P166 R:R:Y95 5.56 2 Yes No 7 8 2 1
L:L:?1 R:R:Y95 32 2 Yes No 0 8 0 1
R:R:C98 R:R:W316 2.61 2 No Yes 8 9 1 1
L:L:?1 R:R:C98 5.97 2 Yes No 0 8 0 1
R:R:E182 R:R:T99 4.23 2 No No 8 8 1 2
R:R:F312 R:R:V102 5.24 2 Yes Yes 9 8 2 2
R:R:V102 R:R:W316 7.36 2 Yes Yes 8 9 2 1
R:R:E182 R:R:W316 9.81 2 No Yes 8 9 1 1
L:L:?1 R:R:E182 8.73 2 Yes No 0 8 0 1
R:R:F312 R:R:W316 10.02 2 Yes Yes 9 9 2 1
R:R:F312 R:R:N350 2.42 2 Yes Yes 9 9 2 2
R:R:Q347 R:R:W316 17.52 2 No Yes 8 9 1 1
R:R:N350 R:R:W316 6.78 2 Yes Yes 9 9 2 1
L:L:?1 R:R:W316 3.22 2 Yes Yes 0 9 0 1
R:R:T323 R:R:Y319 7.49 2 Yes Yes 7 7 2 1
R:R:Y319 R:R:Y340 10.92 2 Yes Yes 7 5 1 2
R:R:A343 R:R:Y319 2.67 0 No Yes 5 7 2 1
R:R:F344 R:R:Y319 7.22 2 Yes Yes 6 7 1 1
R:R:Q347 R:R:Y319 6.76 2 No Yes 8 7 1 1
L:L:?1 R:R:Y319 4.41 2 Yes Yes 0 7 0 1
R:R:T323 R:R:Y340 6.24 2 Yes Yes 7 5 2 2
R:R:F344 R:R:W348 5.01 2 Yes Yes 6 8 1 2
L:L:?1 R:R:F344 6.88 2 Yes Yes 0 6 0 1
L:L:?1 R:R:Q347 17.54 2 Yes No 0 8 0 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub4.00
Average Interaction Strength11.28
Average Nodes In Shell20.00
Average Hubs In Shell13.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8HN8 A Amine Histamine H4 Homo Sapiens Histamine - Gi1/Beta1/Gamma2 3 2023-12-20 To be published

A 2D representation of the interactions of HSM in 8HN8
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:S68 R:R:V64 3.23 2 Yes Yes 8 8 2 2
R:R:V64 R:R:W348 2.45 2 Yes Yes 8 8 2 1
R:R:S68 R:R:W90 2.47 2 Yes Yes 8 7 2 2
R:R:D94 R:R:S68 7.36 2 Yes Yes 8 8 1 2
R:R:S68 R:R:W348 6.18 2 Yes Yes 8 8 2 1
R:R:I69 R:R:W345 5.87 2 Yes Yes 8 8 2 2
R:R:I69 R:R:W348 3.52 2 Yes Yes 8 8 2 1
R:R:W90 R:R:Y72 10.61 2 Yes Yes 7 7 2 2
R:R:F344 R:R:Y72 12.38 2 Yes Yes 6 7 1 2
R:R:W345 R:R:Y72 4.82 2 Yes Yes 8 7 2 2
R:R:W348 R:R:Y72 5.79 2 Yes Yes 8 7 1 2
R:R:W348 R:R:W90 1.87 2 Yes Yes 8 7 1 2
R:R:C98 R:R:D94 3.11 2 Yes Yes 8 8 1 1
R:R:D94 R:R:W348 12.28 2 Yes Yes 8 8 1 1
L:L:?1 R:R:D94 8.94 2 Yes Yes 0 8 0 1
R:R:N147 R:R:Y95 15.12 2 Yes Yes 8 8 2 1
R:R:I151 R:R:Y95 4.84 2 Yes Yes 7 8 2 1
R:R:P166 R:R:Y95 6.95 2 Yes Yes 7 8 2 1
R:R:F169 R:R:Y95 3.09 2 Yes Yes 6 8 2 1
L:L:?1 R:R:Y95 13.24 2 Yes Yes 0 8 0 1
R:R:C98 R:R:W316 2.61 2 Yes Yes 8 9 1 1
R:R:C98 R:R:W348 2.61 2 Yes Yes 8 8 1 1
L:L:?1 R:R:C98 7.47 2 Yes Yes 0 8 0 1
R:R:F312 R:R:V102 7.87 2 Yes Yes 9 8 2 2
R:R:V102 R:R:W316 6.13 2 Yes Yes 8 9 2 1
R:R:I151 R:R:N147 4.25 2 Yes Yes 7 8 2 2
R:R:E182 R:R:N147 2.63 2 No Yes 8 8 1 2
R:R:I151 R:R:P166 3.39 2 Yes Yes 7 7 2 2
R:R:F169 R:R:P166 13 2 Yes Yes 6 7 2 2
R:R:F169 R:R:Y319 2.06 2 Yes Yes 6 7 2 2
R:R:E182 R:R:W316 8.72 2 No Yes 8 9 1 1
L:L:?1 R:R:E182 2.49 2 Yes No 0 8 0 1
R:R:F183 R:R:W316 3.01 0 No Yes 9 9 2 1
R:R:F312 R:R:W316 8.02 2 Yes Yes 9 9 2 1
R:R:Q347 R:R:W316 12.05 2 Yes Yes 8 9 1 1
R:R:N350 R:R:W316 6.78 0 No Yes 9 9 2 1
L:L:?1 R:R:W316 2.14 2 Yes Yes 0 9 0 1
R:R:F344 R:R:Y319 10.32 2 Yes Yes 6 7 1 2
R:R:Q347 R:R:Y319 11.27 2 Yes Yes 8 7 1 2
R:R:F344 R:R:W345 2 2 Yes Yes 6 8 1 2
R:R:F344 R:R:W348 8.02 2 Yes Yes 6 8 1 1
L:L:?1 R:R:F344 17.19 2 Yes Yes 0 6 0 1
R:R:W345 R:R:W348 13.12 2 Yes Yes 8 8 2 1
L:L:?1 R:R:Q347 16.28 2 Yes Yes 0 8 0 1
L:L:?1 R:R:W348 11.79 2 Yes Yes 0 8 0 1
R:R:Q347 R:R:S320 1.44 2 Yes No 8 8 1 2
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub7.00
Average Interaction Strength9.94
Average Nodes In Shell25.00
Average Hubs In Shell21.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell46.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8JXT A Amine Histamine H4 Homo Sapiens Histamine PO4 Gi1/Beta1/Gamma2 3.07 2024-03-20 doi.org/10.1038/s41467-024-46840-5

A 2D representation of the interactions of HSM in 8JXT
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D94 11.16 2 Yes No 0 8 0 1
L:L:?1 R:R:Y95 12.85 2 Yes Yes 0 8 0 1
L:L:?1 R:R:Y319 4.28 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F344 21.14 2 Yes No 0 6 0 1
L:L:?1 R:R:Q347 6.08 2 Yes No 0 8 0 1
L:L:?1 R:R:W348 11.45 2 Yes Yes 0 8 0 1
L:L:?1 W:W:?1 4.36 2 Yes Yes 0 0 0 1
R:R:V64 R:R:W348 2.45 0 No Yes 8 8 2 1
R:R:D94 R:R:S68 5.89 2 No No 8 8 1 2
R:R:S68 R:R:W348 4.94 2 No Yes 8 8 2 1
R:R:I69 R:R:W348 2.35 0 No Yes 8 8 2 1
R:R:D94 R:R:W348 12.28 2 No Yes 8 8 1 1
R:R:N147 R:R:Y95 15.12 0 No Yes 8 8 2 1
R:R:I151 R:R:Y95 2.42 0 Yes Yes 7 8 2 1
R:R:P166 R:R:Y95 6.95 2 Yes Yes 7 8 2 1
R:R:F168 R:R:Y95 3.09 2 Yes Yes 6 8 2 1
R:R:Y95 W:W:?1 8.09 2 Yes Yes 8 0 1 1
R:R:C98 R:R:W316 2.61 0 No Yes 8 9 2 2
R:R:C98 R:R:W348 2.61 0 No Yes 8 8 2 1
R:R:F168 R:R:P166 10.11 2 Yes Yes 6 7 2 2
R:R:F169 R:R:P166 4.33 2 Yes Yes 6 7 2 2
R:R:F168 R:R:F169 4.29 2 Yes Yes 6 6 2 2
R:R:F169 R:R:Y319 2.06 2 Yes Yes 6 7 2 1
R:R:E182 R:R:W316 10.9 2 Yes Yes 8 9 2 2
R:R:E182 W:W:?1 18.29 2 Yes Yes 8 0 2 1
R:R:Q347 R:R:W316 24.09 2 No Yes 8 9 1 2
R:R:W316 W:W:?1 6.55 2 Yes Yes 9 0 2 1
R:R:T323 R:R:Y319 8.74 0 No Yes 7 7 2 1
R:R:Y319 R:R:Y340 4.96 2 Yes No 7 5 1 2
R:R:A343 R:R:Y319 2.67 0 No Yes 5 7 2 1
R:R:F344 R:R:Y319 10.32 2 No Yes 6 7 1 1
R:R:Q347 R:R:Y319 3.38 2 No Yes 8 7 1 1
R:R:F344 R:R:W348 2 2 No Yes 6 8 1 1
R:R:W345 R:R:W348 6.56 0 No Yes 8 8 2 1
R:R:S320 W:W:?1 1.73 0 No Yes 8 0 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub4.00
Average Interaction Strength10.19
Average Nodes In Shell24.00
Average Hubs In Shell11.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell34.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8POK A Amine Histamine H2 Homo Sapiens Histamine - Gs/Beta1/Gamma2 3.4 2024-03-06 doi.org/10.1038/s41467-024-46096-z

A 2D representation of the interactions of HSM in 8POK
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D98 8.68 2 Yes Yes 0 5 0 1
L:L:?1 R:R:V99 5.44 2 Yes No 0 4 0 1
L:L:?1 R:R:C102 2.9 2 Yes No 0 7 0 1
L:L:?1 R:R:D186 2.48 2 Yes Yes 0 4 0 1
L:L:?1 R:R:W247 2.08 2 Yes Yes 0 8 0 1
L:L:?1 R:R:Y250 20.35 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F251 3.34 2 Yes Yes 0 7 0 1
R:R:V71 R:R:Y94 2.52 2 No Yes 6 5 2 2
R:R:D98 R:R:V71 5.84 2 Yes No 5 6 1 2
R:R:D98 R:R:Y94 2.3 2 Yes Yes 5 5 1 2
R:R:D98 R:R:Y278 4.6 2 Yes No 5 6 1 2
R:R:S150 R:R:V99 3.23 9 No No 7 4 2 1
R:R:V176 R:R:V99 3.21 0 No No 5 4 2 1
R:R:C102 R:R:W247 5.22 2 No Yes 7 8 1 1
R:R:F191 R:R:I106 2.51 2 Yes Yes 8 7 2 2
R:R:I106 R:R:W247 2.35 2 Yes Yes 7 8 2 1
R:R:D186 R:R:Y182 6.9 2 Yes Yes 4 5 1 2
R:R:F254 R:R:Y182 2.06 2 Yes Yes 4 5 2 2
R:R:D186 R:R:T190 7.23 2 Yes No 4 5 1 2
R:R:D186 R:R:F251 4.78 2 Yes Yes 4 7 1 1
R:R:D186 R:R:F254 2.39 2 Yes Yes 4 4 1 2
R:R:F191 R:R:W247 3.01 2 Yes Yes 8 8 2 1
R:R:F191 R:R:F251 11.79 2 Yes Yes 8 7 2 1
R:R:W247 R:R:Y250 4.82 2 Yes Yes 8 6 1 1
R:R:F251 R:R:W247 4.01 2 Yes Yes 7 8 1 1
R:R:G277 R:R:W247 2.81 0 No Yes 7 8 2 1
R:R:N280 R:R:W247 6.78 0 Yes Yes 9 8 2 1
R:R:F251 R:R:Y250 4.13 2 Yes Yes 7 6 1 1
R:R:F254 R:R:Y250 5.16 2 Yes Yes 4 6 2 1
R:R:L274 R:R:Y250 2.34 0 No Yes 5 6 2 1
R:R:L274 R:R:Y278 4.69 0 No No 5 6 2 2
R:R:F251 R:R:G187 1.51 2 Yes No 7 5 1 2
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength6.47
Average Nodes In Shell22.00
Average Hubs In Shell12.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell29.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YN2 A Amine Histamine H1 Homo Sapiens Histamine - chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2 2.66 2024-10-09 doi.org/10.1038/s41467-024-52585-y

A 2D representation of the interactions of HSM in 8YN2
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D107 10.22 1 Yes No 0 9 0 1
L:L:?1 R:R:Y108 22.07 1 Yes Yes 0 9 0 1
L:L:?1 R:R:S111 12.72 1 Yes No 0 9 0 1
L:L:?1 R:R:T112 5.55 1 Yes Yes 0 9 0 1
L:L:?1 R:R:W158 7.5 1 Yes Yes 0 8 0 1
L:L:?1 R:R:N198 6.46 1 Yes Yes 0 9 0 1
L:L:?1 R:R:Y431 18.76 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F432 3.44 1 Yes Yes 0 9 0 1
R:R:D107 R:R:V80 7.3 1 No Yes 9 9 1 2
R:R:V80 R:R:Y458 5.05 1 Yes Yes 9 9 2 2
R:R:D107 R:R:Y458 11.49 1 No Yes 9 9 1 2
R:R:W158 R:R:Y108 14.47 1 Yes Yes 8 9 1 1
R:R:I162 R:R:Y108 4.84 1 Yes Yes 9 9 2 1
R:R:T182 R:R:Y108 6.24 0 No Yes 9 9 2 1
R:R:F435 R:R:Y108 3.09 0 No Yes 8 9 2 1
R:R:S111 R:R:W428 3.71 0 No Yes 9 9 1 2
R:R:F116 R:R:T112 6.49 0 No Yes 8 9 2 1
R:R:S155 R:R:T112 6.4 0 No Yes 9 9 2 1
R:R:T112 R:R:W158 9.7 1 Yes Yes 9 8 1 1
R:R:N198 R:R:T112 13.16 1 Yes Yes 9 9 1 1
R:R:I115 R:R:N198 5.66 0 No Yes 9 9 2 1
R:R:I115 R:R:W428 5.87 0 No Yes 9 9 2 2
R:R:F184 R:R:W158 4.01 1 Yes Yes 9 8 2 1
R:R:T194 R:R:W158 7.28 0 No Yes 8 8 2 1
R:R:N198 R:R:W158 5.65 1 Yes Yes 9 8 1 1
R:R:F184 R:R:T182 11.67 1 Yes No 9 9 2 2
R:R:F432 R:R:N198 7.25 1 Yes Yes 9 9 1 1
R:R:F199 R:R:Y200 6.19 1 Yes No 9 8 2 2
R:R:F199 R:R:W428 3.01 1 Yes Yes 9 9 2 2
R:R:F199 R:R:F432 19.29 1 Yes Yes 9 9 2 1
R:R:F432 R:R:Y200 3.09 1 Yes No 9 8 1 2
R:R:F432 R:R:W428 6.01 1 Yes Yes 9 9 1 2
R:R:F432 R:R:Y431 11.35 1 Yes Yes 9 9 1 1
R:R:F435 R:R:Y431 9.28 0 No Yes 8 9 2 1
R:R:T453 R:R:Y431 4.99 0 No Yes 9 9 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength10.84
Average Nodes In Shell23.00
Average Hubs In Shell13.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YN3 A Amine Histamine H2 Homo sapiens Histamine - Gs/Beta1/Gamma2 2.56 2024-10-09 doi.org/10.1038/s41467-024-52585-y

A 2D representation of the interactions of HSM in 8YN3
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D98 11.5 5 Yes No 0 5 0 1
L:L:?1 R:R:V99 14.02 5 Yes No 0 4 0 1
L:L:?1 R:R:C102 10.46 5 Yes Yes 0 7 0 1
L:L:?1 R:R:T103 2.77 5 Yes Yes 0 6 0 1
L:L:?1 R:R:D186 7.66 5 Yes Yes 0 4 0 1
L:L:?1 R:R:W247 3.22 5 Yes Yes 0 8 0 1
L:L:?1 R:R:Y250 22.07 5 Yes Yes 0 6 0 1
L:L:?1 R:R:F251 4.59 5 Yes Yes 0 7 0 1
L:L:?1 R:R:F254 5.73 5 Yes Yes 0 4 0 1
L:L:?1 R:R:Y278 4.41 5 Yes Yes 0 6 0 1
R:R:L67 R:R:V71 5.96 0 Yes No 8 6 2 2
R:R:L67 R:R:L72 2.77 0 Yes Yes 8 7 2 2
R:R:C102 R:R:L67 3.17 5 Yes Yes 7 8 1 2
R:R:D98 R:R:V71 4.38 5 No No 5 6 1 2
R:R:L72 R:R:Y278 8.21 0 Yes Yes 7 6 2 1
R:R:S75 R:R:Y278 7.63 0 No Yes 6 6 2 1
R:R:D98 R:R:Y278 11.49 5 No Yes 5 6 1 1
R:R:S150 R:R:V99 3.23 13 No No 7 4 2 1
R:R:V176 R:R:V99 3.21 0 No No 5 4 2 1
R:R:C102 R:R:W247 5.22 5 Yes Yes 7 8 1 1
R:R:C102 R:R:Y278 2.69 5 Yes Yes 7 6 1 1
R:R:L107 R:R:T103 2.95 0 No Yes 5 6 2 1
R:R:S146 R:R:T103 6.4 0 No Yes 8 6 2 1
R:R:T103 R:R:T190 10.99 0 Yes Yes 6 5 1 2
R:R:I106 R:R:T190 4.56 0 No Yes 7 5 2 2
R:R:I106 R:R:W247 14.09 0 No Yes 7 8 2 1
R:R:D186 R:R:L149 2.71 5 Yes No 4 5 1 2
R:R:F254 R:R:V178 14.42 5 Yes No 4 1 1 2
R:R:R257 R:R:V178 10.46 5 Yes No 4 1 2 2
R:R:D186 R:R:Y182 10.34 5 Yes Yes 4 5 1 2
R:R:F254 R:R:Y182 4.13 5 Yes Yes 4 5 1 2
R:R:F254 R:R:G183 3.01 5 Yes No 4 5 1 2
R:R:D186 R:R:T190 5.78 5 Yes Yes 4 5 1 2
R:R:D186 R:R:F254 5.97 5 Yes Yes 4 4 1 1
R:R:G187 R:R:Y192 2.9 5 No Yes 5 4 2 2
R:R:F251 R:R:G187 3.01 5 Yes No 7 5 1 2
R:R:F251 R:R:T190 5.19 5 Yes Yes 7 5 1 2
R:R:F191 R:R:Y192 9.28 5 Yes Yes 8 4 2 2
R:R:F191 R:R:W247 3.01 5 Yes Yes 8 8 2 1
R:R:F191 R:R:F251 17.15 5 Yes Yes 8 7 2 1
R:R:F251 R:R:Y192 3.09 5 Yes Yes 7 4 1 2
R:R:W247 R:R:Y250 6.75 5 Yes Yes 8 6 1 1
R:R:F251 R:R:W247 8.02 5 Yes Yes 7 8 1 1
R:R:G277 R:R:W247 8.44 0 No Yes 7 8 2 1
R:R:N280 R:R:W247 10.17 0 No Yes 9 8 2 1
R:R:F251 R:R:Y250 3.09 5 Yes Yes 7 6 1 1
R:R:F254 R:R:Y250 7.22 5 Yes Yes 4 6 1 1
R:R:V273 R:R:Y250 3.79 0 No Yes 5 6 2 1
R:R:L274 R:R:Y250 3.52 0 No Yes 5 6 2 1
R:R:F254 R:R:R257 3.21 5 Yes Yes 4 4 1 2
R:R:L274 R:R:Y278 9.38 0 No Yes 5 6 2 1
R:R:W275 R:R:Y278 12.54 0 No Yes 5 6 2 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub8.00
Average Interaction Strength8.64
Average Nodes In Shell34.00
Average Hubs In Shell16.00
Average Links In Shell52.00
Average Links Mediated by Hubs In Shell49.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YN4 A Amine Histamine H2 Homo sapiens Histamine - chim(NtGi1L-Gs-CtGq)/Beta1/Gamma2 2.97 2024-10-09 doi.org/10.1038/s41467-024-52585-y

A 2D representation of the interactions of HSM in 8YN4
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D98 11.5 2 Yes Yes 0 5 0 1
L:L:?1 R:R:V99 7.01 2 Yes No 0 4 0 1
L:L:?1 R:R:C102 8.96 2 Yes Yes 0 7 0 1
L:L:?1 R:R:D186 8.94 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Y250 20.96 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F251 3.44 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F254 5.73 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Y278 4.41 2 Yes Yes 0 6 0 1
R:R:L67 R:R:V71 4.47 0 Yes No 8 6 2 2
R:R:C102 R:R:L67 4.76 2 Yes Yes 7 8 1 2
R:R:D98 R:R:V71 7.3 2 Yes No 5 6 1 2
R:R:V71 R:R:Y278 3.79 2 No Yes 6 6 2 1
R:R:L72 R:R:W275 3.42 2 Yes Yes 7 5 2 2
R:R:L72 R:R:Y278 5.86 2 Yes Yes 7 6 2 1
R:R:S75 R:R:Y278 5.09 0 No Yes 6 6 2 1
R:R:C102 R:R:D98 4.67 2 Yes Yes 7 5 1 1
R:R:D98 R:R:Y278 12.64 2 Yes Yes 5 6 1 1
R:R:S150 R:R:V99 3.23 20 No No 7 4 2 1
R:R:V176 R:R:V99 3.21 0 No No 5 4 2 1
R:R:C102 R:R:W247 6.53 2 Yes Yes 7 8 1 2
R:R:V178 R:R:Y182 3.79 2 Yes Yes 1 5 2 2
R:R:F254 R:R:V178 11.8 2 Yes Yes 4 1 1 2
R:R:R257 R:R:V178 6.54 2 Yes Yes 4 1 2 2
R:R:D186 R:R:Y182 11.49 2 Yes Yes 4 5 1 2
R:R:F254 R:R:Y182 4.13 2 Yes Yes 4 5 1 2
R:R:D186 R:R:T190 5.78 2 Yes Yes 4 5 1 2
R:R:D186 R:R:F254 5.97 2 Yes Yes 4 4 1 1
R:R:G187 R:R:Y192 2.9 2 No Yes 5 4 2 2
R:R:F251 R:R:G187 3.01 2 Yes No 7 5 1 2
R:R:F251 R:R:T190 5.19 2 Yes Yes 7 5 1 2
R:R:F191 R:R:Y192 10.32 2 Yes Yes 8 4 2 2
R:R:F191 R:R:W247 3.01 2 Yes Yes 8 8 2 2
R:R:F191 R:R:F251 13.93 2 Yes Yes 8 7 2 1
R:R:F251 R:R:Y192 3.09 2 Yes Yes 7 4 1 2
R:R:W247 R:R:Y250 2.89 2 Yes Yes 8 6 2 1
R:R:F251 R:R:W247 4.01 2 Yes Yes 7 8 1 2
R:R:F251 R:R:Y250 5.16 2 Yes Yes 7 6 1 1
R:R:F254 R:R:Y250 5.16 2 Yes Yes 4 6 1 1
R:R:V273 R:R:Y250 3.79 0 No Yes 5 6 2 1
R:R:L274 R:R:Y250 7.03 0 No Yes 5 6 2 1
R:R:F254 R:R:R257 3.21 2 Yes Yes 4 4 1 2
R:R:L274 R:R:Y278 10.55 0 No Yes 5 6 2 1
R:R:W275 R:R:Y278 10.61 2 Yes Yes 5 6 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub7.00
Average Interaction Strength8.87
Average Nodes In Shell26.00
Average Hubs In Shell18.00
Average Links In Shell43.00
Average Links Mediated by Hubs In Shell41.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YN5 A Amine Histamine H3 Homo sapiens Histamine - Gi1/Beta1/Gamma2 2.7 2024-10-09 doi.org/10.1038/s41467-024-52585-y

A 2D representation of the interactions of HSM in 8YN5
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D114 14.05 1 Yes Yes 0 9 0 1
L:L:?1 R:R:Y115 8.83 1 Yes Yes 0 9 0 1
L:L:?1 R:R:C118 8.96 1 Yes No 0 8 0 1
L:L:?1 R:R:E206 4.99 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Y374 17.65 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F398 26.36 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L401 11.72 1 Yes No 0 8 0 1
L:L:?1 R:R:W402 11.79 1 Yes Yes 0 8 0 1
R:R:I88 R:R:V83 3.07 1 Yes Yes 9 9 2 2
R:R:V83 R:R:W402 3.68 1 Yes Yes 9 8 2 1
R:R:C87 R:R:D114 6.22 0 No Yes 9 9 2 1
R:R:I88 R:R:W402 12.92 1 Yes Yes 9 8 2 1
R:R:W110 R:R:Y91 10.61 0 Yes Yes 6 8 2 2
R:R:F398 R:R:Y91 11.35 1 Yes Yes 7 8 1 2
R:R:W399 R:R:Y91 5.79 1 Yes Yes 9 8 2 2
R:R:W402 R:R:Y91 8.68 1 Yes Yes 8 8 1 2
R:R:D114 R:R:W110 7.82 1 Yes Yes 9 6 1 2
R:R:D114 R:R:W402 6.7 1 Yes Yes 9 8 1 1
R:R:Y115 R:R:Y167 15.89 1 Yes Yes 9 8 1 2
R:R:I171 R:R:Y115 6.04 1 Yes Yes 7 9 2 1
R:R:A190 R:R:Y115 2.67 1 No Yes 7 9 2 1
R:R:F192 R:R:Y115 5.16 1 Yes Yes 7 9 2 1
R:R:E206 R:R:T119 5.64 0 Yes No 8 9 1 2
R:R:F192 R:R:Y167 4.13 1 Yes Yes 7 8 2 2
R:R:E206 R:R:Y167 15.71 0 Yes Yes 8 8 1 2
R:R:F192 R:R:I171 3.77 1 Yes Yes 7 7 2 2
R:R:A190 R:R:F192 8.32 1 No Yes 7 7 2 2
R:R:E206 R:R:W371 8.72 0 Yes Yes 8 8 1 2
R:R:L401 R:R:W371 17.08 1 No Yes 8 8 1 2
R:R:M378 R:R:Y374 17.96 1 No Yes 8 9 2 1
R:R:S397 R:R:Y374 6.36 0 No Yes 7 9 2 1
R:R:F398 R:R:Y374 9.28 1 Yes Yes 7 9 1 1
R:R:L401 R:R:Y374 5.86 1 No Yes 8 9 1 1
R:R:F398 R:R:Y394 5.16 1 Yes No 7 4 1 2
R:R:F398 R:R:W399 3.01 1 Yes Yes 7 9 1 2
R:R:F398 R:R:W402 9.02 1 Yes Yes 7 8 1 1
R:R:W399 R:R:W402 11.25 1 Yes Yes 9 8 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub6.00
Average Interaction Strength13.04
Average Nodes In Shell24.00
Average Hubs In Shell16.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YN9 A Amine Histamine H4 Homo sapiens Histamine - Gi1/Beta1/Gamma2 2.3 2024-10-09 doi.org/10.1038/s41467-024-52585-y

A 2D representation of the interactions of HSM in 8YN9
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D94 11.5 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Y95 16.55 1 Yes Yes 0 8 0 1
L:L:?1 R:R:C98 7.47 1 Yes Yes 0 8 0 1
L:L:?1 R:R:Y319 7.72 1 Yes Yes 0 7 0 1
L:L:?1 R:R:F344 28.66 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Q347 25.05 1 Yes No 0 8 0 1
L:L:?1 R:R:W348 13.93 1 Yes Yes 0 8 0 1
R:R:I69 R:R:V64 3.07 1 Yes Yes 8 8 2 2
R:R:V64 R:R:W348 3.68 1 Yes Yes 8 8 2 1
R:R:D94 R:R:S68 8.83 1 Yes No 8 8 1 2
R:R:S68 R:R:W348 3.71 1 No Yes 8 8 2 1
R:R:I69 R:R:W345 3.52 1 Yes Yes 8 8 2 2
R:R:I69 R:R:W348 14.09 1 Yes Yes 8 8 2 1
R:R:F344 R:R:Y72 8.25 1 Yes Yes 6 7 1 2
R:R:W345 R:R:Y72 4.82 1 Yes Yes 8 7 2 2
R:R:W348 R:R:Y72 8.68 1 Yes Yes 8 7 1 2
R:R:C98 R:R:D94 4.67 1 Yes Yes 8 8 1 1
R:R:D94 R:R:W348 11.17 1 Yes Yes 8 8 1 1
R:R:N147 R:R:Y95 10.47 1 Yes Yes 8 8 2 1
R:R:I151 R:R:Y95 6.04 1 Yes Yes 7 8 2 1
R:R:P166 R:R:Y95 9.74 1 Yes Yes 7 8 2 1
R:R:C98 R:R:W316 2.61 1 Yes Yes 8 9 1 2
R:R:C98 R:R:W348 2.61 1 Yes Yes 8 8 1 1
R:R:I151 R:R:P166 3.39 1 Yes Yes 7 7 2 2
R:R:F169 R:R:P166 14.45 1 Yes Yes 6 7 2 2
R:R:F169 R:R:Y319 3.09 1 Yes Yes 6 7 2 1
R:R:F169 R:R:T323 2.59 1 Yes Yes 6 7 2 2
R:R:Q347 R:R:W316 26.29 1 No Yes 8 9 1 2
R:R:T323 R:R:Y319 8.74 1 Yes Yes 7 7 2 1
R:R:Y319 R:R:Y340 10.92 1 Yes Yes 7 5 1 2
R:R:F344 R:R:Y319 10.32 1 Yes Yes 6 7 1 1
R:R:Q347 R:R:Y319 6.76 1 No Yes 8 7 1 1
R:R:T323 R:R:Y340 3.75 1 Yes Yes 7 5 2 2
R:R:F344 R:R:W348 8.02 1 Yes Yes 6 8 1 1
R:R:W345 R:R:W348 9.37 1 Yes Yes 8 8 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength15.84
Average Nodes In Shell20.00
Average Hubs In Shell18.00
Average Links In Shell35.00
Average Links Mediated by Hubs In Shell35.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YUU A Amine Histamine H3 Homo Sapiens Histamine - Gi1/Beta1/Gamma1 2.7 2024-06-05 doi.org/10.1002/advs.202310120

A 2D representation of the interactions of HSM in 8YUU
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:C87 R:R:V83 3.42 0 No Yes 9 9 2 2
R:R:V83 R:R:W402 4.9 0 Yes Yes 9 8 2 1
R:R:C87 R:R:D114 7.78 0 No Yes 9 9 2 1
R:R:I88 R:R:W402 10.57 0 Yes Yes 9 8 2 1
R:R:F398 R:R:Y91 10.32 1 Yes Yes 7 8 1 2
R:R:W399 R:R:Y91 7.72 1 Yes Yes 9 8 2 2
R:R:W402 R:R:Y91 6.75 1 Yes Yes 8 8 1 2
R:R:C118 R:R:D114 4.67 1 No Yes 8 9 1 1
R:R:D114 R:R:W402 7.82 1 Yes Yes 9 8 1 1
L:L:?1 R:R:D114 11.16 1 Yes Yes 0 9 0 1
R:R:Y115 R:R:Y167 15.89 0 Yes Yes 9 8 1 2
R:R:I171 R:R:Y115 6.04 0 Yes Yes 7 9 2 1
R:R:F193 R:R:Y115 6.19 5 Yes Yes 5 9 2 1
L:L:?1 R:R:Y115 7.5 1 Yes Yes 0 9 0 1
L:L:?1 R:R:C118 8.7 1 Yes No 0 8 0 1
R:R:L401 R:R:W371 13.67 1 No Yes 8 8 1 2
R:R:M378 R:R:Y374 4.79 0 No Yes 8 9 2 1
R:R:S397 R:R:Y374 8.9 0 No Yes 7 9 2 1
R:R:L401 R:R:Y374 8.21 1 No Yes 8 9 1 1
L:L:?1 R:R:Y374 8.57 1 Yes Yes 0 9 0 1
R:R:F398 R:R:W399 4.01 1 Yes Yes 7 9 1 2
R:R:F398 R:R:W402 12.03 1 Yes Yes 7 8 1 1
L:L:?1 R:R:F398 23.37 1 Yes Yes 0 7 0 1
R:R:W399 R:R:W402 11.25 1 Yes Yes 9 8 2 1
L:L:?1 R:R:L401 8.85 1 Yes No 0 8 0 1
L:L:?1 R:R:W402 10.41 1 Yes Yes 0 8 0 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub5.00
Average Interaction Strength11.22
Average Nodes In Shell19.00
Average Hubs In Shell14.00
Average Links In Shell26.00
Average Links Mediated by Hubs In Shell26.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9LRB A Amine Histamine H1 Homo Sapiens Histamine - Gs/Beta1/Gamma2 2.77 2025-06-11 To be published

A 2D representation of the interactions of HSM in 9LRB
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D107 7.66 1 Yes No 0 9 0 1
L:L:?1 R:R:Y108 27.58 1 Yes Yes 0 9 0 1
L:L:?1 R:R:S111 9.89 1 Yes No 0 9 0 1
L:L:?1 R:R:W158 8.58 1 Yes Yes 0 8 0 1
L:L:?1 R:R:N198 5.17 1 Yes Yes 0 9 0 1
L:L:?1 R:R:W428 4.29 1 Yes Yes 0 9 0 1
L:L:?1 R:R:Y431 19.86 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F432 3.44 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F435 4.59 1 Yes Yes 0 8 0 1
R:R:D107 R:R:V80 7.3 1 No No 9 9 1 2
R:R:V80 R:R:Y458 6.31 1 No Yes 9 9 2 2
R:R:D107 R:R:Y458 12.64 1 No Yes 9 9 1 2
R:R:W158 R:R:Y108 21.22 1 Yes Yes 8 9 1 1
R:R:I162 R:R:Y108 4.84 1 No Yes 9 9 2 1
R:R:T182 R:R:Y108 4.99 1 Yes Yes 9 9 2 1
R:R:F184 R:R:Y108 3.09 1 Yes Yes 9 9 2 1
R:R:S111 R:R:W428 4.94 1 No Yes 9 9 1 1
R:R:T112 R:R:W158 8.49 1 Yes Yes 9 8 2 1
R:R:N198 R:R:T112 11.7 1 Yes Yes 9 9 1 2
R:R:F424 R:R:I115 7.54 1 Yes No 9 9 2 2
R:R:I115 R:R:W428 15.27 1 No Yes 9 9 2 1
R:R:P161 R:R:W158 5.4 0 No Yes 9 8 2 1
R:R:F184 R:R:W158 6.01 1 Yes Yes 9 8 2 1
R:R:F190 R:R:W158 4.01 1 Yes Yes 9 8 2 1
R:R:T194 R:R:W158 4.85 1 No Yes 8 8 2 1
R:R:N198 R:R:W158 3.39 1 Yes Yes 9 8 1 1
R:R:I162 R:R:T182 3.04 1 No Yes 9 9 2 2
R:R:F184 R:R:T182 18.16 1 Yes Yes 9 9 2 2
R:R:F184 R:R:F190 10.72 1 Yes Yes 9 9 2 2
R:R:F190 R:R:T194 7.78 1 Yes No 9 8 2 2
R:R:F435 R:R:K191 22.33 1 Yes No 8 9 1 2
R:R:F435 R:R:T194 5.19 1 Yes No 8 8 1 2
R:R:F432 R:R:N198 7.25 1 Yes Yes 9 9 1 1
R:R:F199 R:R:Y200 8.25 1 Yes No 9 8 2 2
R:R:F199 R:R:F424 4.29 1 Yes Yes 9 9 2 2
R:R:F199 R:R:W428 5.01 1 Yes Yes 9 9 2 1
R:R:F199 R:R:F432 17.15 1 Yes Yes 9 9 2 1
R:R:F432 R:R:Y200 3.09 1 Yes No 9 8 1 2
R:R:F424 R:R:W428 6.01 1 Yes Yes 9 9 2 1
R:R:W428 R:R:Y431 3.86 1 Yes Yes 9 9 1 1
R:R:F432 R:R:W428 7.02 1 Yes Yes 9 9 1 1
R:R:G457 R:R:W428 7.04 0 No Yes 9 9 2 1
R:R:N460 R:R:W428 13.56 0 No Yes 9 9 2 1
R:R:F432 R:R:Y431 8.25 1 Yes Yes 9 9 1 1
R:R:F435 R:R:Y431 7.22 1 Yes Yes 8 9 1 1
R:R:T453 R:R:Y431 4.99 0 No Yes 9 9 2 1
StatisticsValue
Average Number Of Links9.00
Average Number Of Links With An Hub7.00
Average Interaction Strength10.12
Average Nodes In Shell27.00
Average Hubs In Shell15.00
Average Links In Shell46.00
Average Links Mediated by Hubs In Shell45.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9LRC A Amine Histamine H4 Homo Sapiens Histamine - - 2.84 2025-06-11 To be published

A 2D representation of the interactions of HSM in 9LRC
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V64 R:R:W348 3.68 0 No Yes 8 8 2 1
R:R:D94 R:R:S68 8.83 1 Yes No 8 8 1 2
R:R:S68 R:R:W348 3.71 1 No Yes 8 8 2 1
R:R:I69 R:R:W345 3.52 1 Yes Yes 8 8 2 2
R:R:I69 R:R:W348 16.44 1 Yes Yes 8 8 2 1
R:R:W90 R:R:Y72 5.79 1 Yes Yes 7 7 2 2
R:R:F344 R:R:Y72 9.28 1 Yes Yes 6 7 1 2
R:R:W345 R:R:Y72 5.79 1 Yes Yes 8 7 2 2
R:R:W348 R:R:Y72 8.68 1 Yes Yes 8 7 1 2
R:R:D94 R:R:W90 3.35 1 Yes Yes 8 7 1 2
R:R:W348 R:R:W90 3.75 1 Yes Yes 8 7 1 2
R:R:C98 R:R:D94 3.11 1 No Yes 8 8 1 1
R:R:D94 R:R:W348 10.05 1 Yes Yes 8 8 1 1
L:L:?1 R:R:D94 14.05 1 Yes Yes 0 8 0 1
R:R:N147 R:R:Y95 15.12 5 Yes Yes 8 8 2 1
R:R:I151 R:R:Y95 4.84 0 No Yes 7 8 2 1
R:R:P166 R:R:Y95 9.74 1 Yes Yes 7 8 2 1
L:L:?1 R:R:Y95 12.14 1 Yes Yes 0 8 0 1
R:R:C98 R:R:Q347 3.05 1 No Yes 8 8 1 1
L:L:?1 R:R:C98 7.47 1 Yes No 0 8 0 1
R:R:F169 R:R:P166 15.89 1 Yes Yes 6 7 2 2
R:R:F169 R:R:Y319 3.09 1 Yes Yes 6 7 2 1
R:R:F169 R:R:T323 11.67 1 Yes Yes 6 7 2 2
R:R:F169 R:R:Y340 3.09 1 Yes Yes 6 5 2 2
R:R:Q347 R:R:W316 21.9 1 Yes Yes 8 9 1 2
R:R:T323 R:R:Y319 8.74 1 Yes Yes 7 7 2 1
R:R:Y319 R:R:Y340 12.91 1 Yes Yes 7 5 1 2
R:R:F344 R:R:Y319 11.35 1 Yes Yes 6 7 1 1
R:R:Q347 R:R:Y319 5.64 1 Yes Yes 8 7 1 1
L:L:?1 R:R:Y319 3.31 1 Yes Yes 0 7 0 1
R:R:T323 R:R:Y340 6.24 1 Yes Yes 7 5 2 2
R:R:F344 R:R:W348 9.02 1 Yes Yes 6 8 1 1
L:L:?1 R:R:F344 28.66 1 Yes Yes 0 6 0 1
R:R:W345 R:R:W348 13.12 1 Yes Yes 8 8 2 1
L:L:?1 R:R:Q347 25.05 1 Yes Yes 0 8 0 1
L:L:?1 R:R:W348 12.86 1 Yes Yes 0 8 0 1
R:R:A343 R:R:Y319 2.67 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength14.79
Average Nodes In Shell22.00
Average Hubs In Shell17.00
Average Links In Shell37.00
Average Links Mediated by Hubs In Shell37.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9LRD A Amine Histamine H1 Homo Sapiens Histamine - Gi1/Beta1/Gamma2 3.23 2025-06-11 To be published

A 2D representation of the interactions of HSM in 9LRD
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:M81 R:R:V76 3.04 1 Yes Yes 9 9 2 2
R:R:V76 R:R:Y458 3.79 1 Yes Yes 9 9 2 1
R:R:V80 R:R:W103 3.68 1 No Yes 9 9 2 2
R:R:D107 R:R:V80 10.22 1 Yes No 9 9 1 2
R:R:V80 R:R:Y458 5.05 1 No Yes 9 9 2 1
R:R:M81 R:R:W455 4.65 1 Yes Yes 9 9 2 2
R:R:M81 R:R:Y458 11.97 1 Yes Yes 9 9 2 1
R:R:N84 R:R:W103 6.78 1 Yes Yes 8 9 2 2
R:R:N84 R:R:W455 5.65 1 Yes Yes 8 9 2 2
R:R:N84 R:R:Y458 4.65 1 Yes Yes 8 9 2 1
R:R:D107 R:R:W103 3.35 1 Yes Yes 9 9 1 2
R:R:D107 R:R:Y458 11.49 1 Yes Yes 9 9 1 1
L:L:?1 R:R:D107 10.22 1 Yes Yes 0 9 0 1
R:R:W158 R:R:Y108 11.58 1 Yes Yes 8 9 1 1
R:R:I162 R:R:Y108 6.04 1 Yes Yes 9 9 2 1
R:R:T182 R:R:Y108 6.24 1 Yes Yes 9 9 2 1
R:R:F184 R:R:Y108 3.09 1 Yes Yes 9 9 2 1
L:L:?1 R:R:Y108 16.55 1 Yes Yes 0 9 0 1
R:R:S111 R:R:W428 4.94 1 No Yes 9 9 1 1
L:L:?1 R:R:S111 14.13 1 Yes No 0 9 0 1
R:R:F116 R:R:T112 7.78 0 No Yes 8 9 2 1
R:R:S155 R:R:T112 7.99 0 No Yes 9 9 2 1
R:R:T112 R:R:W158 9.7 1 Yes Yes 9 8 1 1
R:R:N198 R:R:T112 10.24 1 Yes Yes 9 9 1 1
L:L:?1 R:R:T112 2.77 1 Yes Yes 0 9 0 1
R:R:F116 R:R:I115 3.77 0 No Yes 8 9 2 2
R:R:I115 R:R:N198 7.08 1 Yes Yes 9 9 2 1
R:R:F424 R:R:I115 3.77 1 Yes Yes 9 9 2 2
R:R:I115 R:R:W428 9.4 1 Yes Yes 9 9 2 1
R:R:I162 R:R:W158 3.52 1 Yes Yes 9 8 2 1
R:R:F184 R:R:W158 4.01 1 Yes Yes 9 8 2 1
R:R:F190 R:R:W158 3.01 1 Yes Yes 9 8 2 1
R:R:T194 R:R:W158 8.49 1 No Yes 8 8 2 1
R:R:N198 R:R:W158 4.52 1 Yes Yes 9 8 1 1
L:L:?1 R:R:W158 4.29 1 Yes Yes 0 8 0 1
R:R:F184 R:R:I162 2.51 1 Yes Yes 9 9 2 2
R:R:F184 R:R:T182 18.16 1 Yes Yes 9 9 2 2
R:R:F184 R:R:F190 15 1 Yes Yes 9 9 2 2
R:R:F190 R:R:T194 7.78 1 Yes No 9 8 2 2
R:R:F435 R:R:K191 23.58 1 Yes No 8 9 1 2
R:R:F435 R:R:T194 5.19 1 Yes No 8 8 1 2
R:R:A195 R:R:F432 2.77 1 Yes Yes 9 9 2 2
R:R:A195 R:R:F435 2.77 1 Yes Yes 9 8 2 1
R:R:F432 R:R:N198 9.67 1 Yes Yes 9 9 2 1
L:L:?1 R:R:N198 5.17 1 Yes Yes 0 9 0 1
R:R:F199 R:R:F424 8.57 1 Yes Yes 9 9 2 2
R:R:F199 R:R:W428 7.02 1 Yes Yes 9 9 2 1
R:R:F199 R:R:F432 12.86 1 Yes Yes 9 9 2 2
R:R:F424 R:R:W428 4.01 1 Yes Yes 9 9 2 1
R:R:W428 R:R:Y431 4.82 1 Yes Yes 9 9 1 1
R:R:F432 R:R:W428 4.01 1 Yes Yes 9 9 2 1
R:R:G457 R:R:W428 8.44 0 No Yes 9 9 2 1
R:R:N460 R:R:W428 13.56 0 No Yes 9 9 2 1
L:L:?1 R:R:W428 3.22 1 Yes Yes 0 9 0 1
R:R:F432 R:R:Y431 7.22 1 Yes Yes 9 9 2 1
R:R:F435 R:R:Y431 8.25 1 Yes Yes 8 9 1 1
R:R:H450 R:R:Y431 3.27 1 No Yes 7 9 2 1
R:R:T453 R:R:Y431 8.74 0 No Yes 9 9 2 1
R:R:I454 R:R:Y431 4.84 1 No Yes 8 9 2 1
L:L:?1 R:R:Y431 16.55 1 Yes Yes 0 9 0 1
L:L:?1 R:R:F435 4.59 1 Yes Yes 0 8 0 1
R:R:H450 R:R:I454 9.28 1 No No 7 8 2 2
R:R:I454 R:R:Y458 8.46 1 No Yes 8 9 2 1
R:R:W455 R:R:Y458 2.89 1 Yes Yes 9 9 2 1
L:L:?1 R:R:Y458 4.41 1 Yes Yes 0 9 0 1
StatisticsValue
Average Number Of Links10.00
Average Number Of Links With An Hub9.00
Average Interaction Strength8.19
Average Nodes In Shell35.00
Average Hubs In Shell24.00
Average Links In Shell65.00
Average Links Mediated by Hubs In Shell64.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9LRE A Amine Histamine H4 Homo Sapiens Histamine - Gi1/Beta1/Gamma2 2.84 2025-06-11 To be published

A 2D representation of the interactions of HSM in 9LRE
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
R:R:V64 R:R:W348 3.68 0 Yes Yes 8 8 2 1
R:R:D94 R:R:S68 8.83 1 Yes No 8 8 1 2
R:R:S68 R:R:W348 3.71 1 No Yes 8 8 2 1
R:R:I69 R:R:W345 3.52 1 Yes Yes 8 8 2 2
R:R:I69 R:R:W348 12.92 1 Yes Yes 8 8 2 1
R:R:F344 R:R:Y72 9.28 1 Yes Yes 6 7 1 2
R:R:W345 R:R:Y72 5.79 1 Yes Yes 8 7 2 2
R:R:W348 R:R:Y72 8.68 1 Yes Yes 8 7 1 2
R:R:D94 R:R:Y95 4.6 1 Yes Yes 8 8 1 1
R:R:C98 R:R:D94 3.11 1 No Yes 8 8 1 1
R:R:D94 R:R:W348 10.05 1 Yes Yes 8 8 1 1
L:L:?1 R:R:D94 14.05 1 Yes Yes 0 8 0 1
R:R:N147 R:R:Y95 16.28 1 Yes Yes 8 8 2 1
R:R:I151 R:R:Y95 4.84 0 No Yes 7 8 2 1
R:R:P166 R:R:Y95 9.74 1 Yes Yes 7 8 2 1
L:L:?1 R:R:Y95 14.34 1 Yes Yes 0 8 0 1
R:R:C98 R:R:Q347 3.05 1 No Yes 8 8 1 1
L:L:?1 R:R:C98 7.47 1 Yes No 0 8 0 1
R:R:Q347 R:R:W316 21.9 1 Yes Yes 8 9 1 2
R:R:T323 R:R:Y319 8.74 1 Yes Yes 7 7 2 1
R:R:Y319 R:R:Y340 12.91 1 Yes Yes 7 5 1 2
R:R:F344 R:R:Y319 9.28 1 Yes Yes 6 7 1 1
R:R:Q347 R:R:Y319 6.76 1 Yes Yes 8 7 1 1
L:L:?1 R:R:Y319 6.62 1 Yes Yes 0 7 0 1
R:R:T323 R:R:Y340 6.24 1 Yes Yes 7 5 2 2
R:R:F344 R:R:W348 9.02 1 Yes Yes 6 8 1 1
L:L:?1 R:R:F344 27.51 1 Yes Yes 0 6 0 1
R:R:W345 R:R:W348 12.18 1 Yes Yes 8 8 2 1
L:L:?1 R:R:Q347 26.31 1 Yes Yes 0 8 0 1
L:L:?1 R:R:W348 11.79 1 Yes Yes 0 8 0 1
R:R:A343 R:R:Y319 2.67 0 No Yes 5 7 2 1
StatisticsValue
Average Number Of Links7.00
Average Number Of Links With An Hub6.00
Average Interaction Strength15.44
Average Nodes In Shell20.00
Average Hubs In Shell16.00
Average Links In Shell31.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9IXJ A Amine Histamine H2 Homo Sapiens Histamine - Gs/Beta1/Gamma2 2.92 2025-07-30 To be published

A 2D representation of the interactions of HSM in 9IXJ
colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

(Click to enlarge 🔍)
Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:D98 10.22 2 Yes No 0 5 0 1
L:L:?1 R:R:V99 11.22 2 Yes No 0 4 0 1
L:L:?1 R:R:C102 5.97 2 Yes No 0 7 0 1
L:L:?1 R:R:D186 5.11 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Y250 14.34 2 Yes Yes 0 6 0 1
L:L:?1 R:R:F251 2.29 2 Yes Yes 0 7 0 1
L:L:?1 R:R:F254 4.59 2 Yes Yes 0 4 0 1
L:L:?1 R:R:Y278 3.31 2 Yes Yes 0 6 0 1
R:R:D98 R:R:V71 4.38 2 No No 5 6 1 2
R:R:L72 R:R:Y278 7.03 0 Yes Yes 7 6 2 1
R:R:S75 R:R:W275 2.47 2 No Yes 6 5 2 2
R:R:S75 R:R:Y278 2.54 2 No Yes 6 6 2 1
R:R:D98 R:R:Y278 9.2 2 No Yes 5 6 1 1
R:R:S150 R:R:V99 6.46 9 Yes No 7 4 2 1
R:R:C102 R:R:W247 3.92 0 No Yes 7 8 1 2
R:R:I106 R:R:W247 2.35 2 No Yes 7 8 2 2
R:R:F251 R:R:I106 2.51 2 Yes No 7 7 1 2
R:R:L149 R:R:Y182 2.34 0 No Yes 5 5 2 2
R:R:D186 R:R:L149 4.07 2 Yes No 4 5 1 2
R:R:F254 R:R:V178 7.87 2 Yes No 4 1 1 2
R:R:F254 R:R:Y182 2.06 2 Yes Yes 4 5 1 2
R:R:F254 R:R:G183 3.01 2 Yes No 4 5 1 2
R:R:D186 R:R:T190 4.34 2 Yes No 4 5 1 2
R:R:D186 R:R:F254 3.58 2 Yes Yes 4 4 1 1
R:R:F191 R:R:W247 4.01 2 Yes Yes 8 8 2 2
R:R:F191 R:R:F251 3.22 2 Yes Yes 8 7 2 1
R:R:W247 R:R:Y250 4.82 2 Yes Yes 8 6 2 1
R:R:F251 R:R:W247 4.01 2 Yes Yes 7 8 1 2
R:R:F251 R:R:Y250 4.13 2 Yes Yes 7 6 1 1
R:R:F254 R:R:Y250 3.09 2 Yes Yes 4 6 1 1
R:R:L274 R:R:Y278 2.34 0 No Yes 5 6 2 1
R:R:W275 R:R:Y278 4.82 2 Yes Yes 5 6 2 1
StatisticsValue
Average Number Of Links8.00
Average Number Of Links With An Hub5.00
Average Interaction Strength7.13
Average Nodes In Shell23.00
Average Hubs In Shell12.00
Average Links In Shell32.00
Average Links Mediated by Hubs In Shell31.00
Physico-chemical properties of the nodes interacting with this ligand (click to enlarge 🔍)
Location of the nodes interacting with this ligand (click to enlarge 🔍)
StatisticsValue
Average Number Of Links7.61
Average Number Of Links With An Hub5.52
Average Interaction Strength11.02
Average Nodes In Shell22.61
Average Hubs In Shell13.97
Average Links In Shell34.61
Average Links Mediated by Hubs In Shell33.65

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Physico-chemical properties of the nodes interacting with this ligand

(Click to enlarge 🔍)

missing image


Location of the nodes interacting with this ligand

(Click to enlarge 🔍)