psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E41	R:R:Q38	17.84	No	No	0	5	3
2	R:R:E41	R:R:R104	8.14	No	No	0	5	4
3	R:R:L47	R:R:M44	2.83	No	No	0	5	4
4	R:R:A99	R:R:M48	3.22	No	No	0	6	6
5	R:R:M48	R:R:V102	4.56	No	No	0	6	5
6	R:R:V52	R:R:V95	3.21	No	No	0	5	7
7	R:R:A57	R:R:L53	3.15	No	No	0	4	5
8	R:R:A337	R:R:L54	4.73	No	No	0	6	5
9	R:R:I55	R:R:N59	4.25	Yes	Yes	1	7	9
10	R:R:G91	R:R:I55	7.05	No	Yes	0	7	7
11	R:R:I55	R:R:S336	6.19	Yes	Yes	1	7	9
12	R:R:G58	R:R:P340	4.06	No	Yes	0	8	9
13	R:R:D87	R:R:N59	6.73	Yes	Yes	1	9	9
14	R:R:L88	R:R:N59	2.75	No	Yes	0	7	9
15	R:R:N59	R:R:S336	2.98	Yes	Yes	1	9	9
16	R:R:N59	R:R:P340	9.77	Yes	Yes	0	9	9
17	R:R:L88	R:R:V60	2.98	No	No	0	7	3
18	R:R:L356	R:R:L61	4.15	No	No	0	6	6
19	R:R:I66	R:R:V62	3.07	Yes	Yes	0	7	9
20	R:R:P340	R:R:V62	3.53	Yes	Yes	0	9	9
21	R:R:V62	R:R:Y343	3.79	Yes	No	5	9	9
22	R:R:F349	R:R:V62	5.24	Yes	Yes	5	8	9
23	R:R:A84	R:R:I63	3.25	No	No	0	8	7
24	R:R:A64	R:R:L356	4.73	No	No	0	4	6
25	R:R:A65	R:R:F349	4.16	No	Yes	0	7	8
26	R:R:G67	R:R:I66	3.53	No	Yes	0	2	7
27	R:R:I66	R:R:I80	2.94	Yes	No	0	7	7
28	R:R:I66	R:R:T81	3.04	Yes	No	0	7	5
29	R:R:R71	R:R:T69	3.88	No	No	0	5	6
30	R:R:L72	R:R:T69	8.84	No	No	0	8	6
31	R:R:A352	R:R:T69	5.03	No	No	0	7	6
32	R:R:Q70	R:R:R71	5.84	No	No	0	6	5
33	R:R:Q70	R:R:Q73	3.84	No	No	0	6	7
34	R:R:D348	R:R:L72	2.71	No	No	0	6	8
35	R:R:N77	R:R:T74	5.85	No	No	0	9	7
36	R:R:L75	R:R:M153	4.24	No	No	0	6	6
37	R:R:L75	R:R:R155	3.64	No	No	0	6	3
38	R:R:D138	R:R:T76	2.89	No	Yes	0	9	8
39	R:R:R139	R:R:T76	6.47	No	Yes	0	9	8
40	R:R:T76	R:R:Y149	3.75	Yes	No	0	8	7
41	R:R:L78	R:R:T81	7.37	No	No	0	5	5
42	R:R:I162	R:R:L78	4.28	No	No	0	7	5
43	R:R:F79	R:R:V134	6.55	Yes	No	0	8	5
44	R:R:F79	R:R:I135	5.02	Yes	No	0	8	9
45	R:R:A158	R:R:F79	2.77	No	Yes	0	7	8
46	R:R:I135	R:R:I80	2.94	No	No	0	9	7
47	R:R:I80	R:R:Y343	16.92	No	No	0	7	9
48	R:R:S82	R:R:T131	6.4	No	No	0	9	8
49	R:R:I162	R:R:S82	9.29	No	No	0	7	9
50	R:R:S82	R:R:W166	6.18	No	No	0	9	9
51	R:R:D87	R:R:L83	4.07	Yes	Yes	1	9	9
52	R:R:L83	R:R:S128	4.5	Yes	No	1	9	9
53	R:R:L83	R:R:T131	5.9	Yes	No	0	9	8
54	R:R:L132	R:R:L83	2.77	Yes	Yes	1	8	9
55	R:R:L83	R:R:N339	4.12	Yes	Yes	1	9	9
56	R:R:D87	R:R:S128	2.94	Yes	No	1	9	9
57	R:R:D87	R:R:S336	8.83	Yes	Yes	1	9	9
58	R:R:D87	R:R:N339	10.77	Yes	Yes	1	9	9
59	R:R:C124	R:R:V89	3.42	No	No	0	6	6
60	R:R:G91	R:R:V90	3.68	No	No	0	7	8
61	R:R:C124	R:R:V90	5.12	No	No	0	6	8
62	R:R:S336	R:R:V90	8.08	Yes	No	0	9	8
63	R:R:G91	R:R:V95	3.68	No	No	0	7	7
64	R:R:V94	R:R:W117	3.68	No	Yes	0	7	6
65	R:R:D121	R:R:V94	4.38	No	No	3	7	7
66	R:R:V94	R:R:Y333	5.05	No	Yes	3	7	7
67	R:R:P96	R:R:V95	3.53	No	No	0	9	7
68	R:R:F97	R:R:P96	2.89	Yes	No	0	4	9
69	R:R:F97	R:R:W109	7.02	Yes	Yes	4	4	5
70	R:R:F97	R:R:L113	6.09	Yes	No	4	4	4
71	R:R:F97	R:R:W117	7.02	Yes	Yes	0	4	6
72	R:R:G98	R:R:W117	5.63	No	Yes	0	6	6
73	R:R:G98	R:R:W330	2.81	No	Yes	0	6	6
74	R:R:T100	R:R:W109	13.34	No	Yes	0	4	5
75	R:R:L101	R:R:W107	3.42	No	Yes	0	5	7
76	R:R:V102	R:R:W330	3.68	No	Yes	0	5	6
77	R:R:W107	R:R:W109	14.99	Yes	Yes	4	7	5
78	R:R:G110	R:R:W107	2.81	No	Yes	0	7	7
79	R:R:C114	R:R:W107	5.22	No	Yes	4	9	7
80	R:R:W107	R:R:W117	14.06	Yes	Yes	0	7	6
81	R:R:C199	R:R:W107	7.84	No	Yes	4	9	7
82	R:R:L108	R:R:W109	3.42	No	Yes	0	4	5
83	R:R:L113	R:R:W109	5.69	No	Yes	4	4	5
84	R:R:C114	R:R:S111	5.16	No	No	0	9	4
85	R:R:F112	R:R:L116	6.09	No	No	0	2	4
86	R:R:C114	R:R:C199	7.28	No	No	4	9	9
87	R:R:E115	R:R:I177	2.73	No	Yes	0	6	6
88	R:R:E115	R:R:H180	9.85	No	No	0	6	5
89	R:R:T118	R:R:W117	3.64	No	Yes	0	6	6
90	R:R:I177	R:R:T118	3.04	Yes	No	0	6	6
91	R:R:C199	R:R:T118	3.38	No	No	0	9	6
92	R:R:F174	R:R:S119	10.57	Yes	No	2	5	6
93	R:R:I177	R:R:S119	10.84	Yes	No	2	6	6
94	R:R:M178	R:R:S119	4.6	Yes	No	2	4	6
95	R:R:F174	R:R:L120	6.09	Yes	No	0	5	5
96	R:R:D121	R:R:N329	4.04	No	Yes	3	7	6
97	R:R:D121	R:R:Y333	9.2	No	Yes	3	7	7
98	R:R:S173	R:R:V122	4.85	No	No	0	7	6
99	R:R:L123	R:R:S169	3	No	No	0	5	8
100	R:R:L123	R:R:S173	3	No	No	0	5	7
101	R:R:V125	R:R:W303	4.9	No	Yes	3	6	8
102	R:R:F307	R:R:V125	2.62	Yes	No	3	7	6
103	R:R:E130	R:R:T126	7.06	No	No	0	6	6
104	R:R:S169	R:R:T126	4.8	No	No	0	8	6
105	R:R:S215	R:R:T126	9.59	No	No	0	6	6
106	R:R:A127	R:R:W166	6.48	No	No	0	7	9
107	R:R:F299	R:R:S128	3.96	Yes	No	0	9	9
108	R:R:C133	R:R:I129	3.27	No	Yes	1	6	8
109	R:R:I129	R:R:P219	5.08	Yes	No	0	8	9
110	R:R:I129	R:R:M223	4.37	Yes	Yes	1	8	8
111	R:R:F299	R:R:I129	6.28	Yes	Yes	0	9	8
112	R:R:E130	R:R:I168	4.1	No	No	0	6	4
113	R:R:T131	R:R:V165	3.17	No	No	0	8	6
114	R:R:L132	R:R:M223	2.83	Yes	Yes	1	8	8
115	R:R:L132	R:R:M296	2.83	Yes	Yes	1	8	8
116	R:R:F299	R:R:L132	6.09	Yes	Yes	0	9	8
117	R:R:C133	R:R:M223	8.1	No	Yes	1	6	8
118	R:R:I161	R:R:V134	3.07	No	No	0	6	5
119	R:R:I135	R:R:L292	4.28	No	No	0	9	8
120	R:R:D138	R:R:M153	6.93	No	No	0	9	6
121	R:R:A142	R:R:R139	5.53	No	No	0	8	9
122	R:R:E285	R:R:R139	5.82	Yes	No	0	7	9
123	R:R:T144	R:R:Y140	16.23	No	Yes	0	7	8
124	R:R:R229	R:R:Y140	15.43	No	Yes	0	5	8
125	R:R:A142	R:R:Y149	5.34	No	No	0	8	7
126	R:R:E233	R:R:I143	5.47	No	No	0	6	9
127	R:R:E233	R:R:T144	7.06	No	No	0	6	7
128	R:R:F147	R:R:P146	11.56	No	No	0	6	8
129	R:R:R148	R:R:S151	6.59	No	No	0	5	5
130	R:R:L152	R:R:R148	6.07	No	No	0	5	5
131	R:R:A156	R:R:T154	3.36	No	No	0	5	8
132	R:R:R157	R:R:T154	7.76	No	No	0	7	8
133	R:R:I161	R:R:V160	4.61	No	No	0	6	3
134	R:R:I168	R:R:T164	3.04	No	No	0	4	3
135	R:R:F174	R:R:M178	4.98	Yes	Yes	2	5	4
136	R:R:L175	R:R:P176	3.28	No	No	0	6	7
137	R:R:P176	R:R:Y207	5.56	No	Yes	0	7	7
138	R:R:I177	R:R:M178	4.37	Yes	Yes	2	6	4
139	R:R:I177	R:R:W182	4.7	Yes	Yes	2	6	5
140	R:R:M179	R:R:W181	9.31	No	No	0	5	6
141	R:R:H180	R:R:W182	6.35	No	Yes	0	5	5
142	R:R:W182	R:R:Y193	8.68	Yes	Yes	2	5	3
143	R:R:F201	R:R:W182	13.03	No	Yes	2	4	5
144	R:R:T203	R:R:W182	6.06	Yes	Yes	2	4	5
145	R:R:W182	R:R:Y207	5.79	Yes	Yes	2	5	7
146	R:R:R183	R:R:Y193	3.09	No	Yes	0	4	3
147	R:R:D184	R:R:D186	3.99	No	No	0	4	1
148	R:R:D184	R:R:N204	4.04	No	No	0	4	5
149	R:R:D186	R:R:P187	6.44	No	No	0	1	1
150	R:R:P187	R:R:Q188	3.16	No	No	0	1	2
151	R:R:A189	R:R:Y193	5.34	No	Yes	2	4	3
152	R:R:A189	R:R:V202	5.09	No	No	2	4	4
153	R:R:C192	R:R:C198	7.28	No	No	0	4	5
154	R:R:V202	R:R:Y193	8.83	No	Yes	2	4	3
155	R:R:D195	R:R:P196	4.83	No	No	0	3	3
156	R:R:D195	R:R:G197	5.03	No	No	0	3	4
157	R:R:C198	R:R:D200	3.11	No	No	0	5	5
158	R:R:F201	R:R:T203	9.08	No	Yes	2	4	4
159	R:R:T203	R:R:Y207	6.24	Yes	Yes	2	4	7
160	R:R:N204	R:R:Y207	4.65	No	Yes	0	5	7
161	R:R:A206	R:R:R205	2.77	No	No	0	4	5
162	R:R:S211	R:R:Y207	5.09	No	Yes	0	6	7
163	R:R:I213	R:R:I214	2.94	No	No	0	4	4
164	R:R:I214	R:R:S215	4.64	No	No	0	4	6
165	R:R:F216	R:R:Y217	4.13	Yes	No	0	7	5
166	R:R:F216	R:R:L220	7.31	Yes	Yes	0	7	6
167	R:R:F216	R:R:L304	4.87	Yes	Yes	0	7	7
168	R:R:F216	R:R:F307	21.43	Yes	Yes	0	7	7
169	R:R:L221	R:R:Y217	3.52	No	No	0	3	5
170	R:R:L308	R:R:Y217	4.69	No	No	0	6	5
171	R:R:I218	R:R:P219	3.39	No	No	0	5	9
172	R:R:L220	R:R:L221	2.77	Yes	No	0	6	3
173	R:R:I224	R:R:L220	4.28	No	Yes	0	5	6
174	R:R:L220	R:R:T300	2.95	Yes	No	0	6	5
175	R:R:I224	R:R:M223	4.37	No	Yes	0	5	8
176	R:R:M223	R:R:M296	8.66	Yes	Yes	1	8	8
177	R:R:F225	R:R:V226	2.62	No	No	0	5	6
178	R:R:A227	R:R:Y231	2.67	No	No	0	9	6
179	R:R:L289	R:R:Y231	5.86	No	No	0	7	6
180	R:R:G293	R:R:Y231	2.9	No	No	0	5	6
181	R:R:E233	R:R:E236	7.61	No	No	0	6	4
182	R:R:I238	R:R:Q237	16.47	No	No	0	5	7
183	R:R:H286	R:R:Q237	19.78	No	No	0	5	7
184	R:R:P347	R:R:R284	7.21	No	No	0	6	6
185	R:R:D348	R:R:R284	4.76	No	No	0	6	6
186	R:R:R345	R:R:T291	11.64	No	No	0	7	8
187	R:R:I294	R:R:I342	5.89	No	No	0	7	8
188	R:R:I294	R:R:R345	6.26	No	No	0	7	7
189	R:R:I295	R:R:N339	2.83	No	Yes	0	8	9
190	R:R:I295	R:R:I342	7.36	No	No	0	8	8
191	R:R:M338	R:R:V298	3.04	No	No	0	6	6
192	R:R:F299	R:R:W303	4.01	Yes	Yes	0	9	8
193	R:R:F299	R:R:N335	9.67	Yes	No	0	9	9
194	R:R:L304	R:R:T300	4.42	Yes	No	0	7	5
195	R:R:C302	R:R:L331	3.17	No	No	0	8	7
196	R:R:C302	R:R:M338	3.24	No	No	0	8	6
197	R:R:F306	R:R:W303	3.01	Yes	Yes	3	7	8
198	R:R:F307	R:R:W303	8.02	Yes	Yes	3	7	8
199	R:R:N329	R:R:W303	6.78	Yes	Yes	3	6	8
200	R:R:G332	R:R:W303	8.44	No	Yes	0	6	8
201	R:R:L304	R:R:P305	3.28	Yes	No	0	7	9
202	R:R:L304	R:R:L308	9.69	Yes	No	0	7	6
203	R:R:F328	R:R:P305	5.78	Yes	No	0	5	9
204	R:R:F306	R:R:F307	12.86	Yes	Yes	3	7	7
205	R:R:F306	R:R:F328	4.29	Yes	Yes	0	7	5
206	R:R:F306	R:R:N329	15.71	Yes	Yes	3	7	6
207	R:R:F325	R:R:V309	2.62	No	No	0	4	4
208	R:R:F328	R:R:V309	2.62	Yes	No	0	5	4
209	R:R:N310	R:R:N313	8.17	No	No	0	6	4
210	R:R:V312	R:R:V320	3.21	No	No	0	5	5
211	R:R:F315	R:R:V314	3.93	No	No	0	5	5
212	R:R:L319	R:R:N316	13.73	No	No	0	6	4
213	R:R:D322	R:R:F325	4.78	No	No	0	3	4
214	R:R:L324	R:R:W323	7.97	No	No	0	4	3
215	R:R:F328	R:R:L324	4.87	Yes	No	0	5	4
216	R:R:F328	R:R:L331	3.65	Yes	No	0	5	7
217	R:R:N329	R:R:Y333	6.98	Yes	Yes	3	6	7
218	R:R:W330	R:R:Y333	22.19	Yes	Yes	0	6	7
219	R:R:A334	R:R:M338	3.22	No	No	0	4	6
220	R:R:N335	R:R:N339	5.45	No	Yes	0	9	9
221	R:R:F349	R:R:Y343	6.19	Yes	No	5	8	9
222	R:R:P347	R:R:S346	3.56	No	No	0	6	8
223	R:R:A86	R:R:W166	2.59	No	No	0	8	9
224	R:R:V230	R:R:Y140	2.52	No	Yes	0	9	8
225	R:R:F79	R:R:M153	2.49	Yes	No	0	8	6
226	R:R:K354	R:R:R355	2.48	No	No	0	4	4
227	R:R:E285	R:R:H286	2.46	Yes	No	0	7	5
228	R:R:V326	R:R:W330	2.45	No	Yes	0	4	6
229	R:R:F349	R:R:L72	2.44	Yes	No	0	8	8
230	R:R:F174	R:R:L123	2.44	Yes	No	0	5	5
231	R:R:L108	R:R:R104	2.43	No	No	0	4	4
232	R:R:F325	R:R:N310	2.42	No	No	0	4	6
233	R:R:L141	R:R:Y140	2.34	No	Yes	0	5	8
234	R:R:Q150	R:R:R155	2.34	No	No	0	5	3
235	R:R:A57	R:R:G58	1.95	No	No	0	4	8
236	R:R:G105	R:R:T106	1.82	No	No	0	4	3
237	R:R:P196	R:R:S111	1.78	No	No	0	3	4
238	R:R:P146	R:R:S145	1.78	No	No	0	8	6
239	R:R:P321	R:R:V320	1.77	No	No	0	5	5
240	R:R:G293	R:R:M296	1.75	No	Yes	0	5	8
241	R:R:A42	R:R:S45	1.71	No	No	0	5	5
242	R:R:C192	R:R:V202	1.71	No	No	0	4	4
243	R:R:A84	R:R:V62	1.7	No	Yes	0	8	9
244	R:R:A99	R:R:V103	1.7	No	No	0	6	5
245	R:R:A136	R:R:V226	1.7	No	No	0	8	6
246	R:R:A208	R:R:V314	1.7	No	No	0	6	5
247	R:R:I341	R:R:P340	1.69	No	Yes	0	6	9
248	R:R:A208	R:R:T203	1.68	No	Yes	0	6	4
249	R:R:C344	R:R:I341	1.64	No	No	0	6	6
250	R:R:S211	R:R:S212	1.63	No	No	0	6	6
251	R:R:S45	R:R:V103	1.62	No	No	0	5	5
252	R:R:A337	R:R:I55	1.62	No	Yes	0	6	7
253	R:R:S215	R:R:V172	1.62	No	No	0	6	5
254	R:R:A206	R:R:I209	1.62	No	No	0	4	5
255	R:R:A136	R:R:M223	1.61	No	Yes	1	8	8
256	R:R:A136	R:R:M296	1.61	No	Yes	1	8	8
257	R:R:V52	R:R:V56	1.6	No	No	0	5	6
258	R:R:S145	R:R:T144	1.6	No	No	0	6	7
259	R:R:V309	R:R:V320	1.6	No	No	0	4	5
260	R:R:A57	R:R:L61	1.58	No	No	0	4	6
261	R:R:A65	R:R:L356	1.58	No	No	0	7	6
262	R:R:A234	R:R:L289	1.58	No	No	0	8	7
263	R:R:T74	R:R:T76	1.57	No	Yes	0	7	8
264	R:R:I137	R:R:V134	1.54	No	No	0	6	5
265	R:R:I222	R:R:V226	1.54	No	No	0	6	6
266	R:R:M281	R:R:V280	1.52	No	No	0	4	3
267	R:R:L47	R:R:V51	1.49	No	No	0	5	6
268	R:R:L50	R:R:V51	1.49	No	No	0	4	6
269	R:R:L92	R:R:V56	1.49	No	No	0	5	6
270	R:R:L93	R:R:V89	1.49	No	No	0	4	6
271	R:R:L108	R:R:T106	1.47	No	No	0	4	3
272	R:R:K351	R:R:K354	1.44	No	No	0	4	4
273	R:R:L47	R:R:M48	1.41	No	No	0	5	6
274	R:R:K159	R:R:L78	1.41	No	No	0	4	5
275	R:R:L116	R:R:M178	1.41	No	Yes	0	4	4
276	R:R:L175	R:R:M179	1.41	No	No	0	6	5
277	R:R:L141	R:R:L152	1.38	No	No	0	5	5
278	R:R:E285	R:R:I143	1.37	Yes	No	0	7	9
279	R:R:D318	R:R:L319	1.36	No	No	0	2	6
280	R:R:L36	R:R:Q39	1.33	No	No	0	1	2
281	R:R:E185	R:R:L190	1.33	No	No	0	2	1
282	R:R:L282	R:R:Q237	1.33	No	No	0	3	7
283	R:R:E285	R:R:L282	1.33	Yes	No	0	7	3
284	R:R:F315	R:R:I311	1.26	No	No	0	5	5
285	R:R:L152	R:R:R157	1.21	No	No	0	5	7
286	R:R:N204	R:R:R205	1.21	No	No	0	5	5
287	R:R:E185	R:R:R183	1.16	No	No	0	2	4
288	R:R:L36	R:R:W40	1.14	No	No	0	1	3
289	R:R:F349	R:R:F353	1.07	Yes	No	0	8	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I55	4.7775	4	1	7
2	R:R:N59	5.296	5	1	9
3	R:R:V62	3.466	5	5	9
4	R:R:I66	3.145	4	0	7
5	R:R:T76	3.67	4	0	8
6	R:R:F79	4.2075	4	0	8
7	R:R:L83	4.272	5	1	9
8	R:R:D87	6.668	5	1	9
9	R:R:F97	5.755	4	4	4
10	R:R:W107	8.05667	6	4	7
11	R:R:W109	8.892	5	4	5
12	R:R:W117	6.806	5	0	6
13	R:R:I129	4.75	4	1	8
14	R:R:L132	3.63	4	1	8
15	R:R:Y140	9.13	4	0	8
16	R:R:F174	6.02	4	2	5
17	R:R:I177	5.136	5	2	6
18	R:R:M178	3.84	4	2	4
19	R:R:W182	7.435	6	2	5
20	R:R:Y193	6.485	4	2	3
21	R:R:T203	5.765	4	2	4
22	R:R:Y207	5.466	5	2	7
23	R:R:F216	9.435	4	0	7
24	R:R:L220	4.3275	4	0	6
25	R:R:M223	4.99	6	1	8
26	R:R:E285	2.745	4	0	7
27	R:R:M296	3.7125	4	1	8
28	R:R:F299	6.002	5	0	9
29	R:R:W303	5.86	6	3	8
30	R:R:L304	5.565	4	0	7
31	R:R:F306	8.9675	4	3	7
32	R:R:F307	11.2325	4	3	7
33	R:R:F328	4.242	5	0	5
34	R:R:N329	8.3775	4	3	6
35	R:R:W330	7.7825	4	0	6
36	R:R:Y333	10.855	4	3	7
37	R:R:S336	6.52	4	1	9
38	R:R:N339	5.7925	4	1	9
39	R:R:P340	4.7625	4	0	9
40	R:R:F349	3.82	5	5	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L108	R:R:W109	16.3326	3.42	No	Yes	0	4	5
2	R:R:F97	R:R:W109	17.1583	7.02	Yes	Yes	4	4	5
3	R:R:F97	R:R:W117	52.9446	7.02	Yes	Yes	0	4	6
4	R:R:V102	R:R:W330	12.5023	3.68	No	Yes	0	5	6
5	R:R:M48	R:R:V102	11.3419	4.56	No	No	0	6	5
6	R:R:W107	R:R:W109	14.0373	14.99	Yes	Yes	4	7	5
7	R:R:W107	R:R:W117	19.9083	14.06	Yes	Yes	0	7	6
8	R:R:F97	R:R:P96	55.4763	2.89	Yes	No	0	4	9
9	R:R:P96	R:R:V95	55.6291	3.53	No	No	0	9	7
10	R:R:N59	R:R:P340	86.9339	9.77	Yes	Yes	0	9	9
11	R:R:I55	R:R:N59	52.2025	4.25	Yes	Yes	1	7	9
12	R:R:G91	R:R:I55	53.8322	7.05	No	Yes	0	7	7
13	R:R:G91	R:R:V95	57.1569	3.68	No	No	0	7	7
14	R:R:D87	R:R:N59	39.0055	6.73	Yes	Yes	1	9	9
15	R:R:P340	R:R:V62	82.8307	3.53	Yes	Yes	0	9	9
16	R:R:F349	R:R:V62	11.8402	5.24	Yes	Yes	5	8	9
17	R:R:I66	R:R:V62	37.0703	3.07	Yes	Yes	0	7	9
18	R:R:V62	R:R:Y343	34.1348	3.79	Yes	No	5	9	9
19	R:R:I66	R:R:I80	35.2625	2.94	Yes	No	0	7	7
20	R:R:I80	R:R:Y343	36.0882	16.92	No	No	0	7	9
21	R:R:I135	R:R:I80	69.8556	2.94	No	No	0	9	7
22	R:R:F79	R:R:I135	67.102	5.02	Yes	No	0	8	9
23	R:R:F79	R:R:M153	58.2736	2.49	Yes	No	0	8	6
24	R:R:D138	R:R:M153	52.3771	6.93	No	No	0	9	6
25	R:R:D138	R:R:T76	50.8457	2.89	No	Yes	0	9	8
26	R:R:R139	R:R:T76	43.0432	6.47	No	Yes	0	9	8
27	R:R:D87	R:R:L83	14.1755	4.07	Yes	Yes	1	9	9
28	R:R:L83	R:R:T131	17.3802	5.9	Yes	No	0	9	8
29	R:R:S82	R:R:T131	13.8009	6.4	No	No	0	9	8
30	R:R:D87	R:R:S128	25.8812	2.94	Yes	No	1	9	9
31	R:R:V94	R:R:W117	74.2461	3.68	No	Yes	0	7	6
32	R:R:D121	R:R:V94	37.5432	4.38	No	No	3	7	7
33	R:R:D121	R:R:N329	38.0197	4.04	No	Yes	3	7	6
34	R:R:N329	R:R:W303	60.0815	6.78	Yes	Yes	3	6	8
35	R:R:F299	R:R:W303	67.3311	4.01	Yes	Yes	0	9	8
36	R:R:F299	R:R:S128	33.9093	3.96	Yes	No	0	9	9
37	R:R:V94	R:R:Y333	37.5832	5.05	No	Yes	3	7	7
38	R:R:N329	R:R:Y333	48.4158	6.98	Yes	Yes	3	6	7
39	R:R:F299	R:R:L132	22.1745	6.09	Yes	Yes	0	9	8
40	R:R:T118	R:R:W117	98.3558	3.64	No	Yes	0	6	6
41	R:R:I177	R:R:T118	100	3.04	Yes	No	0	6	6
42	R:R:I177	R:R:M178	27.6199	4.37	Yes	Yes	2	6	4
43	R:R:I177	R:R:W182	51.5551	4.7	Yes	Yes	2	6	5
44	R:R:I177	R:R:S119	24.368	10.84	Yes	No	2	6	6
45	R:R:F174	R:R:S119	22.8111	10.57	Yes	No	2	5	6
46	R:R:F174	R:R:M178	22.913	4.98	Yes	Yes	2	5	4
47	R:R:F174	R:R:L123	39.2819	2.44	Yes	No	0	5	5
48	R:R:L123	R:R:S169	29.5588	3	No	No	0	5	8
49	R:R:F307	R:R:W303	13.7827	8.02	Yes	Yes	3	7	8
50	R:R:F306	R:R:N329	26.4341	15.71	Yes	Yes	3	7	6
51	R:R:F306	R:R:F307	10.0251	12.86	Yes	Yes	3	7	7
52	R:R:S169	R:R:T126	26.3032	4.8	No	No	0	8	6
53	R:R:S215	R:R:T126	13.208	9.59	No	No	0	6	6
54	R:R:F299	R:R:I129	11.2182	6.28	Yes	Yes	0	9	8
55	R:R:L132	R:R:M223	11.8548	2.83	Yes	Yes	1	8	8
56	R:R:L132	R:R:M296	14.6266	2.83	Yes	Yes	1	8	8
57	R:R:E285	R:R:R139	39.9658	5.82	Yes	No	0	7	9
58	R:R:E285	R:R:I143	28.9804	1.37	Yes	No	0	7	9
59	R:R:E233	R:R:I143	27.3435	5.47	No	No	0	6	9
60	R:R:E233	R:R:T144	24.026	7.06	No	No	0	6	7
61	R:R:T144	R:R:Y140	17.3038	16.23	No	Yes	0	7	8
62	R:R:L141	R:R:Y140	12.1858	2.34	No	Yes	0	5	8
63	R:R:L141	R:R:L152	10.4652	1.38	No	No	0	5	5
64	R:R:W182	R:R:Y207	25.0409	5.79	Yes	Yes	2	5	7
65	R:R:W182	R:R:Y193	15.1286	8.68	Yes	Yes	2	5	3
66	R:R:N204	R:R:Y207	13.7318	4.65	No	Yes	0	5	7
67	R:R:F216	R:R:F307	21.4106	21.43	Yes	Yes	0	7	7
68	R:R:F306	R:R:F328	28.8567	4.29	Yes	Yes	0	7	5
69	R:R:A136	R:R:V226	11.782	1.7	No	No	0	8	6
70	R:R:F328	R:R:V309	13.1498	2.62	Yes	No	0	5	4
71	R:R:W330	R:R:Y333	10.5307	22.19	Yes	Yes	0	6	7
72	R:R:L132	R:R:L83	21.1124	2.77	Yes	Yes	1	8	9
73	R:R:F306	R:R:W303	12.9097	3.01	Yes	Yes	3	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 4GPO

PDB Summary
PDB	4GPO
Class	A
SubFamily	Amine
Type	Adrenergic
SubType	Beta1
Species	Meleagris gallopavo
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	3.5
Date	2013-02-27
D.O.I.	10.1038/nsmb.2504

Net Summary
I_min	2.62
Number of Linked Nodes	255
Number of Links	289
Number of Hubs	40
Number of Links mediated by Hubs	137
Number of Communities	5
Number of Nodes involved in Communities	41
Number of Links involved in Communities	56

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	63917
Length Of Smallest Path	3
Average Path Length	14.8632
Length of Longest Path	37
Minimum Path Strength	1.235
Average Path Strength	5.3066
Maximum Path Strength	18.125
Minimum Path Correlation	0.7
Average Path Correlation	0.93149
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.84615
Average % Of Corr. Nodes	46.9926
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.05
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07700
Sequence	>4GPO_Chain_R L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G S T Q R L Q T L T N L F I T S L A C A D L V V G L L V V P F G A T L V V R G T W L W G S F L C E L W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S P F R Y Q S L M T R A R A K V I I C T V W A I S A L V S F L P I M M H W W R D E D P Q A L K C Y Q D P G C C D F V T N R A Y A I A S S I I S F Y I P L L I M I F V A L R V Y R E A K E Q I V M L M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N R D L V P D W L F V A F N W L G Y A N S A M N P I I Y C R S P D F R K A F K R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2VT4	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.7	2008-06-24	10.1038/nature07101
	2Y00	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.5	2011-01-12	10.1038/nature09746
	2Y01	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.6	2011-03-30	10.1038/nature09746
	2Y02	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carmoterol	-	-	2.6	2011-01-12	10.1038/nature09746
	2Y03	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.85	2011-01-12	10.1038/nature09746
	2Y04	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	3.05	2011-01-12	10.1038/nature09746
	2YCW	A	Amine	Adrenergic	β₁	Meleagris gallopavo	(S)-Carazolol	-	-	3	2011-06-01	10.1073/pnas.1100185108
	2YCX	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.25	2011-06-01	10.1073/pnas.1100185108
	2YCY	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.15	2011-06-08	10.1073/pnas.1100185108
	2YCZ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Iodocyanopindolol	-	-	3.65	2011-06-01	10.1073/pnas.1100185108
	3ZPQ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	4-(piperazin-1- yl)-1H-indole	Na	-	2.8	2013-04-03	10.1021/jm400140q
	3ZPR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	4-methyl-2-(piperazin-1-yl)	Na	-	2.7	2013-04-03	10.1021/jm400140q
	4AMI	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Bucindolol	-	-	3.2	2012-05-23	10.1016/j.str.2012.03.014
	4AMJ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	(S)-Carvedilol	-	-	2.3	2012-05-23	10.1016/j.str.2012.03.014
	4BVN	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	Na	-	2.1	2014-04-02	10.1371/journal.pone.0092727
	5A8E	A	Amine	Adrenergic	β₁	Meleagris gallopavo	7-Methylcyanopindolol	Na	-	2.4	2015-09-30	10.1124/mol.115.101030
	5F8U	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.35	2015-12-23	10.1038/nsmb.3130
	6H7J	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.8	2018-10-17	10.1126/science.aau5595
	6H7L	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.7	2018-10-17	10.1126/science.aau5595
	6H7M	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	2.76	2018-10-17	10.1126/science.aau5595
	6H7N	A	Amine	Adrenergic	β₁	Meleagris gallopavo	(S)-Xamoterol	-	-	2.5	2018-10-17	10.1101/436212
	6H7O	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.8	2018-10-17	10.1126/science.aau5595
	6IBL	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	-	2.7	2019-01-09	10.1038/s41586-020-2419-1
	6TKO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	Arrestin2	3.3	2020-06-17	10.1038/s41586-020-2419-1
	7BTS	A	Amine	Adrenergic	β₁	Homo sapiens	L-Epinephrine	-	-	3.13	2020-12-02	10.1038/s41422-020-00424-2
	7BU6	A	Amine	Adrenergic	β₁	Homo sapiens	L-Norepinephrine	-	-	2.7	2020-12-02	10.1038/s41422-020-00424-2
	7BU7	A	Amine	Adrenergic	β₁	Homo sapiens	BI167107	-	-	2.6	2020-12-02	10.1038/s41422-020-00424-2
	7BVQ	A	Amine	Adrenergic	β₁	Homo sapiens	(S)-Carazolol	-	-	2.5	2020-12-02	10.1038/s41422-020-00424-2
	7JJO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gs/&β;1/&γ;2	2.6	2020-09-02	10.1016/j.molcel.2020.08.001
	7S0F	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gi1/&β;1/&γ;2	2.96	2021-11-17	10.1038/s41594-021-00679-2
	7S0G	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	chim(Gi1-CtGs)/&β;1/&γ;2	3.86	2021-11-17	10.1038/s41594-021-00679-2
	8DCR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	Gs/&β;1/&γ;2	2.6	2022-07-27	10.1038/s41467-022-31823-1
	8DCS	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	Gs/&β;1/&γ;2	2.5	2022-07-27	10.1038/s41467-022-31823-1
	4GPO (Dimer)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	-	-	-	3.5	2013-02-27	10.1038/nsmb.2504

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