psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D121	20.11	Yes	No	1	0	7
2	L:L:?1	R:R:V122	12.04	Yes	No	0	0	6
3	L:L:?1	R:R:F201	7.38	Yes	Yes	1	0	4
4	L:L:?1	R:R:T203	3.97	Yes	Yes	1	0	4
5	L:L:?1	R:R:S211	10.11	Yes	No	0	0	6
6	L:L:?1	R:R:S215	4.04	Yes	No	0	0	6
7	L:L:?1	R:R:F306	9.84	Yes	Yes	1	0	7
8	L:L:?1	R:R:F307	6.56	Yes	Yes	1	0	7
9	L:L:?1	R:R:N310	7.4	Yes	No	1	0	6
10	L:L:?1	R:R:N329	11.1	Yes	No	1	0	6
11	L:L:?1	R:R:Y333	3.95	Yes	Yes	1	0	7
12	R:R:M44	R:R:M48	5.78	No	Yes	1	4	6
13	R:R:A99	R:R:M48	4.83	No	Yes	0	6	6
14	R:R:M48	R:R:V102	6.09	Yes	No	1	6	5
15	R:R:M48	R:R:W330	18.61	Yes	Yes	1	6	6
16	R:R:G91	R:R:I55	3.53	No	Yes	0	7	7
17	R:R:I55	R:R:S336	4.64	Yes	No	0	7	9
18	R:R:L92	R:R:V56	4.47	No	No	0	5	6
19	R:R:G58	R:R:P340	4.06	No	No	0	8	9
20	R:R:D87	R:R:N59	8.08	Yes	No	0	9	9
21	R:R:N59	R:R:P340	8.15	No	No	0	9	9
22	R:R:P340	R:R:V62	3.53	No	No	0	9	9
23	R:R:C344	R:R:V62	5.12	No	No	0	6	9
24	R:R:I66	R:R:N77	9.91	No	Yes	3	7	9
25	R:R:I66	R:R:T81	4.56	No	No	0	7	5
26	R:R:F349	R:R:I66	5.02	Yes	No	3	8	7
27	R:R:L72	R:R:T69	10.32	Yes	No	0	8	6
28	R:R:R355	R:R:T69	6.47	No	No	0	4	6
29	R:R:Q70	R:R:Q73	7.68	No	No	0	6	7
30	R:R:D348	R:R:R71	7.15	No	No	0	6	5
31	R:R:L72	R:R:N77	4.12	Yes	Yes	3	8	9
32	R:R:F349	R:R:L72	9.74	Yes	Yes	3	8	8
33	R:R:L75	R:R:M153	7.07	No	No	0	6	6
34	R:R:D138	R:R:T76	4.34	Yes	No	0	9	8
35	R:R:I80	R:R:N77	5.66	No	Yes	0	7	9
36	R:R:F349	R:R:N77	7.25	Yes	Yes	3	8	9
37	R:R:L78	R:R:R155	6.07	No	No	0	5	3
38	R:R:F79	R:R:V134	7.87	Yes	No	0	8	5
39	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
40	R:R:D138	R:R:F79	7.17	Yes	Yes	0	9	8
41	R:R:F79	R:R:I162	5.02	Yes	No	0	8	7
42	R:R:S82	R:R:T131	7.99	No	No	0	9	8
43	R:R:I162	R:R:S82	4.64	No	No	0	7	9
44	R:R:S82	R:R:W166	6.18	No	No	0	9	9
45	R:R:D87	R:R:L83	4.07	Yes	Yes	4	9	9
46	R:R:L83	R:R:T131	5.9	Yes	No	0	9	8
47	R:R:L132	R:R:L83	5.54	No	Yes	0	8	9
48	R:R:L83	R:R:N339	10.98	Yes	Yes	4	9	9
49	R:R:D87	R:R:S128	5.89	Yes	No	0	9	9
50	R:R:D87	R:R:S336	11.78	Yes	No	0	9	9
51	R:R:D87	R:R:N339	6.73	Yes	Yes	4	9	9
52	R:R:L88	R:R:L92	5.54	No	No	0	7	5
53	R:R:C124	R:R:V89	5.12	No	No	0	6	6
54	R:R:G91	R:R:V90	3.68	No	No	0	7	8
55	R:R:S336	R:R:V90	4.85	No	No	0	9	8
56	R:R:L120	R:R:L93	4.15	No	No	0	5	4
57	R:R:D121	R:R:V94	11.69	No	No	1	7	7
58	R:R:V94	R:R:Y333	3.79	No	Yes	1	7	7
59	R:R:P96	R:R:V95	3.53	No	No	0	9	7
60	R:R:V95	R:R:Y333	6.31	No	Yes	0	7	7
61	R:R:F97	R:R:W109	6.01	No	Yes	0	4	5
62	R:R:F97	R:R:W117	10.02	No	No	0	4	6
63	R:R:T100	R:R:W109	4.85	No	Yes	0	4	5
64	R:R:V102	R:R:W330	3.68	No	Yes	1	5	6
65	R:R:L108	R:R:R104	3.64	No	No	0	4	4
66	R:R:W107	R:R:W109	13.12	Yes	Yes	0	7	5
67	R:R:C114	R:R:W107	5.22	No	Yes	6	9	7
68	R:R:W107	R:R:W117	11.25	Yes	No	0	7	6
69	R:R:C199	R:R:W107	15.67	No	Yes	6	9	7
70	R:R:L108	R:R:W109	9.11	No	Yes	0	4	5
71	R:R:P196	R:R:S111	3.56	No	No	0	3	4
72	R:R:C114	R:R:C199	7.28	No	No	6	9	9
73	R:R:E115	R:R:M178	9.47	No	No	0	6	4
74	R:R:E115	R:R:H180	7.39	No	No	0	6	5
75	R:R:F201	R:R:T118	5.19	Yes	No	0	4	6
76	R:R:F174	R:R:S119	11.89	Yes	No	0	5	6
77	R:R:I177	R:R:S119	10.84	No	No	0	6	6
78	R:R:D121	R:R:Y333	10.34	No	Yes	1	7	7
79	R:R:L123	R:R:S173	7.51	No	No	7	5	7
80	R:R:F174	R:R:L123	6.09	Yes	No	7	5	5
81	R:R:V125	R:R:W303	9.81	No	Yes	0	6	8
82	R:R:S169	R:R:T126	6.4	No	No	0	8	6
83	R:R:S215	R:R:T126	9.59	No	No	0	6	6
84	R:R:A127	R:R:W166	7.78	No	No	0	7	9
85	R:R:F299	R:R:I129	6.28	Yes	No	0	9	8
86	R:R:I129	R:R:W303	8.22	No	Yes	0	8	8
87	R:R:E130	R:R:P219	6.29	No	Yes	0	6	9
88	R:R:L132	R:R:Y343	8.21	No	Yes	0	8	9
89	R:R:C133	R:R:P219	3.77	No	Yes	0	6	9
90	R:R:C133	R:R:I222	6.55	No	No	0	6	6
91	R:R:I135	R:R:R139	3.76	No	No	0	9	9
92	R:R:A136	R:R:Y227	5.34	No	Yes	0	8	9
93	R:R:D138	R:R:Y149	9.2	Yes	No	5	9	7
94	R:R:D138	R:R:M153	4.16	Yes	No	5	9	6
95	R:R:R139	R:R:Y227	7.2	No	Yes	0	9	9
96	R:R:R139	R:R:Y343	6.17	No	Yes	0	9	9
97	R:R:T144	R:R:Y140	12.48	No	Yes	2	7	8
98	R:R:V226	R:R:Y140	8.83	No	Yes	0	6	8
99	R:R:R229	R:R:Y140	5.14	Yes	Yes	2	5	8
100	R:R:A142	R:R:Y149	9.34	No	No	0	8	7
101	R:R:R229	R:R:T144	7.76	Yes	No	2	5	7
102	R:R:R148	R:R:S145	5.27	No	No	0	5	6
103	R:R:M153	R:R:Y149	8.38	No	No	5	6	7
104	R:R:R157	R:R:T154	5.17	No	No	0	7	8
105	R:R:F174	R:R:S173	6.61	Yes	No	7	5	7
106	R:R:L175	R:R:P176	4.93	No	No	0	6	7
107	R:R:L175	R:R:W181	4.56	No	No	0	6	6
108	R:R:I177	R:R:W182	7.05	No	Yes	0	6	5
109	R:R:M179	R:R:W181	8.14	No	No	0	5	6
110	R:R:H180	R:R:R183	14.67	No	No	0	5	4
111	R:R:R183	R:R:W182	14.99	No	Yes	1	4	5
112	R:R:W182	R:R:Y193	9.65	Yes	No	1	5	3
113	R:R:F201	R:R:W182	7.02	Yes	Yes	1	4	5
114	R:R:T203	R:R:W182	3.64	Yes	Yes	1	4	5
115	R:R:W182	R:R:Y207	4.82	Yes	Yes	1	5	7
116	R:R:R183	R:R:Y193	31.9	No	No	1	4	3
117	R:R:D186	R:R:P187	8.05	Yes	No	0	1	1
118	R:R:D186	R:R:Q188	3.92	Yes	No	0	1	2
119	R:R:K191	R:R:Q188	6.78	No	No	0	3	2
120	R:R:A189	R:R:Y193	5.34	No	No	0	4	3
121	R:R:C192	R:R:C198	7.28	No	No	8	4	5
122	R:R:C192	R:R:D200	4.67	No	No	8	4	5
123	R:R:D195	R:R:P196	6.44	No	No	0	3	3
124	R:R:C198	R:R:D200	7.78	No	No	8	5	5
125	R:R:F201	R:R:T203	7.78	Yes	Yes	1	4	4
126	R:R:F201	R:R:Y207	4.13	Yes	Yes	1	4	7
127	R:R:R317	R:R:V202	3.92	No	No	0	1	4
128	R:R:T203	R:R:Y207	4.99	Yes	Yes	1	4	7
129	R:R:N204	R:R:Y207	3.49	No	Yes	0	5	7
130	R:R:S211	R:R:Y207	13.99	No	Yes	0	6	7
131	R:R:N310	R:R:S212	4.47	No	No	0	6	6
132	R:R:I311	R:R:S212	6.19	No	No	0	5	6
133	R:R:F216	R:R:Y217	9.28	Yes	No	0	7	5
134	R:R:F216	R:R:L220	3.65	Yes	No	1	7	6
135	R:R:F216	R:R:F299	4.29	Yes	Yes	1	7	9
136	R:R:F216	R:R:L304	3.65	Yes	No	0	7	7
137	R:R:F216	R:R:F307	24.65	Yes	Yes	1	7	7
138	R:R:I311	R:R:Y217	4.84	No	No	0	5	5
139	R:R:F299	R:R:L220	6.09	Yes	No	1	9	6
140	R:R:M223	R:R:M296	4.33	No	No	0	8	8
141	R:R:F299	R:R:M223	8.71	Yes	No	0	9	8
142	R:R:L292	R:R:Y227	3.52	No	Yes	0	8	9
143	R:R:I295	R:R:Y227	7.25	No	Yes	0	8	9
144	R:R:M296	R:R:Y227	3.59	No	Yes	0	8	9
145	R:R:R229	R:R:R232	7.46	Yes	No	2	5	4
146	R:R:E233	R:R:R229	8.14	No	Yes	2	6	5
147	R:R:K235	R:R:Y231	11.94	No	No	0	5	6
148	R:R:L289	R:R:Y231	8.21	No	No	0	7	6
149	R:R:L292	R:R:Y231	3.52	No	No	0	8	6
150	R:R:E233	R:R:R232	5.82	No	No	2	6	4
151	R:R:E236	R:R:R232	8.14	No	No	0	4	4
152	R:R:E285	R:R:K235	14.85	No	No	0	7	5
153	R:R:K240	R:R:Q237	5.42	No	No	0	5	7
154	R:R:K240	R:R:R239	4.95	No	No	0	5	5
155	R:R:I241	R:R:R284	3.76	No	No	0	5	6
156	R:R:D242	R:R:R284	8.34	No	No	0	4	6
157	R:R:E285	R:R:R247	6.98	No	No	0	7	3
158	R:R:K290	R:R:T291	4.5	No	No	0	7	8
159	R:R:I294	R:R:K290	4.36	No	No	0	7	7
160	R:R:F338	R:R:V298	5.24	No	No	0	6	6
161	R:R:I342	R:R:V298	4.61	No	No	0	8	6
162	R:R:L304	R:R:T300	4.42	No	No	0	7	5
163	R:R:C302	R:R:N335	9.45	No	No	0	8	9
164	R:R:F306	R:R:W303	7.02	Yes	Yes	1	7	8
165	R:R:F307	R:R:W303	9.02	Yes	Yes	1	7	8
166	R:R:G332	R:R:W303	11.26	No	Yes	0	6	8
167	R:R:N335	R:R:W303	6.78	No	Yes	0	9	8
168	R:R:L304	R:R:L308	6.92	No	No	0	7	6
169	R:R:F328	R:R:P305	10.11	Yes	No	0	5	9
170	R:R:F306	R:R:F307	11.79	Yes	Yes	1	7	7
171	R:R:F306	R:R:F325	6.43	Yes	No	1	7	4
172	R:R:F306	R:R:N329	9.67	Yes	No	1	7	6
173	R:R:F307	R:R:N310	3.62	Yes	No	1	7	6
174	R:R:N313	R:R:V309	4.43	No	Yes	1	4	4
175	R:R:V309	R:R:V320	8.02	Yes	No	0	4	5
176	R:R:F325	R:R:V309	7.87	No	Yes	1	4	4
177	R:R:F328	R:R:V309	3.93	Yes	Yes	0	5	4
178	R:R:N313	R:R:R317	4.82	No	No	0	4	1
179	R:R:F325	R:R:N313	6.04	No	No	1	4	4
180	R:R:F315	R:R:V314	5.24	No	No	0	5	5
181	R:R:L319	R:R:N316	5.49	No	No	0	6	4
182	R:R:P321	R:R:V320	3.53	No	No	0	5	5
183	R:R:P321	R:R:W323	9.46	No	No	0	5	3
184	R:R:D322	R:R:V326	4.38	No	No	0	3	4
185	R:R:L324	R:R:W323	7.97	No	No	0	4	3
186	R:R:F328	R:R:L324	9.74	Yes	No	0	5	4
187	R:R:F327	R:R:F328	4.29	No	Yes	0	5	5
188	R:R:F327	R:R:L331	8.53	No	No	0	5	7
189	R:R:N329	R:R:Y333	11.63	No	Yes	1	6	7
190	R:R:W330	R:R:Y333	7.72	Yes	Yes	1	6	7
191	R:R:N335	R:R:N339	5.45	No	Yes	0	9	9
192	R:R:N339	R:R:Y343	3.49	Yes	Yes	0	9	9
193	R:R:I342	R:R:Y343	7.25	No	Yes	0	8	9
194	R:R:C344	R:R:F349	16.76	No	Yes	0	6	8
195	R:R:R345	R:R:R350	6.4	No	No	0	7	8
196	R:R:P347	R:R:S346	3.56	No	No	0	6	8
197	R:R:F349	R:R:S346	6.61	Yes	No	0	8	8
198	R:R:F349	R:R:F353	7.5	Yes	No	0	8	7
199	R:R:L101	R:R:W107	3.42	No	Yes	0	5	7
200	R:R:A84	R:R:V62	3.39	No	No	0	8	9
201	R:R:I129	R:R:P219	3.39	No	Yes	0	8	9
202	R:R:I218	R:R:P219	3.39	No	Yes	0	5	9
203	R:R:D195	R:R:G197	3.35	No	No	0	3	4
204	R:R:A84	R:R:I63	3.25	No	No	0	8	7
205	R:R:V52	R:R:V95	3.21	No	No	0	5	7
206	R:R:A64	R:R:L356	3.15	No	No	0	4	6
207	R:R:A158	R:R:L75	3.15	No	No	0	7	6
208	R:R:C198	R:R:D195	3.11	No	No	0	5	3
209	R:R:F225	R:R:Y140	3.09	No	Yes	0	5	8
210	R:R:A189	R:R:D186	3.09	No	Yes	0	4	1
211	L:L:?1	R:R:W117	3.07	Yes	No	0	0	6
212	R:R:I161	R:R:V134	3.07	No	No	0	6	5
213	R:R:I143	R:R:V230	3.07	No	No	0	9	9
214	R:R:I214	R:R:V172	3.07	No	Yes	0	4	5
215	R:R:I168	R:R:T164	3.04	No	No	0	4	3
216	R:R:L120	R:R:V89	2.98	No	No	0	5	6
217	R:R:L108	R:R:T106	2.95	No	No	0	4	3
218	R:R:I137	R:R:I222	2.94	No	No	0	6	6
219	R:R:I213	R:R:I218	2.94	No	No	0	4	5
220	R:R:I294	R:R:I342	2.94	No	No	0	7	8
221	R:R:D200	R:R:V202	2.92	No	No	0	5	4
222	R:R:I224	R:R:M296	2.92	No	No	0	5	8
223	R:R:E130	R:R:V165	2.85	No	No	0	6	6
224	R:R:I137	R:R:L141	2.85	No	No	0	6	5
225	R:R:I224	R:R:L228	2.85	No	No	0	5	2
226	R:R:L116	R:R:M178	2.83	No	No	0	4	4
227	R:R:G110	R:R:W107	2.81	No	Yes	0	7	7
228	R:R:P176	R:R:Y207	2.78	No	Yes	0	7	7
229	R:R:L357	R:R:L61	2.77	No	No	0	6	6
230	R:R:A65	R:R:F353	2.77	No	No	0	7	7
231	R:R:L171	R:R:L175	2.77	No	No	0	4	6
232	R:R:E233	R:R:I143	2.73	No	No	0	6	9
233	R:R:E285	R:R:I238	2.73	No	No	0	7	5
234	R:R:D348	R:R:L72	2.71	No	Yes	0	6	8
235	R:R:D318	R:R:N316	2.69	No	No	0	2	4
236	R:R:D184	R:R:D186	2.66	No	Yes	0	4	1
237	R:R:R205	R:R:V314	2.62	No	No	0	5	5
238	R:R:D184	R:R:E185	2.6	No	No	0	4	2
239	R:R:A86	R:R:W166	2.59	No	No	0	8	9
240	R:R:V226	R:R:Y227	2.52	No	Yes	0	6	9
241	R:R:F315	R:R:I209	2.51	No	No	0	5	5
242	R:R:I238	R:R:R284	2.51	No	No	0	5	6
243	R:R:V326	R:R:W330	2.45	No	Yes	0	4	6
244	R:R:F353	R:R:L61	2.44	No	No	0	7	6
245	R:R:F112	R:R:L113	2.44	No	No	0	2	4
246	R:R:F174	R:R:L120	2.44	Yes	No	0	5	5
247	R:R:D318	R:R:R317	2.38	No	No	0	2	1
248	R:R:L113	R:R:W109	2.28	No	Yes	0	4	5
249	L:L:?1	R:R:A208	2.12	Yes	No	0	0	6
250	R:R:A57	R:R:G58	1.95	No	No	0	4	8
251	R:R:G91	R:R:V56	1.84	No	No	0	7	6
252	R:R:G105	R:R:T106	1.82	No	No	0	4	3
253	R:R:A352	R:R:A65	1.79	No	No	0	7	7
254	R:R:P146	R:R:S145	1.78	No	No	0	8	6
255	R:R:G98	R:R:L101	1.71	No	No	0	6	5
256	R:R:A208	R:R:V314	1.7	No	No	0	6	5
257	R:R:C85	R:R:T81	1.69	No	No	0	5	5
258	R:R:A156	R:R:T154	1.68	No	No	0	5	8
259	R:R:G67	R:R:Q73	1.64	No	No	0	2	7
260	R:R:A337	R:R:I55	1.62	No	Yes	0	6	7
261	R:R:S211	R:R:V172	1.62	No	Yes	0	6	5
262	R:R:S215	R:R:V172	1.62	No	Yes	0	6	5
263	R:R:T164	R:R:V160	1.59	No	No	0	3	3
264	R:R:A337	R:R:L54	1.58	No	No	0	6	5
265	R:R:A65	R:R:L356	1.58	No	No	0	7	6
266	R:R:A158	R:R:L78	1.58	No	No	0	7	5
267	R:R:A170	R:R:L123	1.58	No	No	0	3	5
268	R:R:A206	R:R:N204	1.56	No	No	0	4	5
269	R:R:I55	R:R:V51	1.54	Yes	No	0	7	6
270	R:R:I168	R:R:V172	1.54	No	Yes	0	4	5
271	R:R:M44	R:R:V103	1.52	No	No	1	4	5
272	R:R:M48	R:R:V103	1.52	Yes	No	1	6	5
273	R:R:L152	R:R:S145	1.5	No	No	0	5	6
274	R:R:L319	R:R:V312	1.49	No	No	0	6	5
275	R:R:L50	R:R:L54	1.38	No	No	0	4	5
276	R:R:L141	R:R:L152	1.38	No	No	0	5	5
277	R:R:R355	R:R:S68	1.32	No	No	0	4	5
278	R:R:K351	R:R:R71	1.24	No	No	0	4	5
279	R:R:K290	R:R:R345	1.24	No	No	0	7	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.82231	13	1	0
2	R:R:M48	7.366	5	1	6
3	R:R:I55	2.8325	4	0	7
4	R:R:L72	6.7225	4	3	8
5	R:R:N77	6.735	4	3	9
6	R:R:F79	5.9575	4	0	8
7	R:R:L83	6.6225	4	4	9
8	R:R:D87	7.31	5	4	9
9	R:R:W107	8.58167	6	6	7
10	R:R:W109	7.074	5	0	5
11	R:R:D138	6.2175	4	5	9
12	R:R:Y140	7.385	4	2	8
13	R:R:V172	1.9625	4	0	5
14	R:R:F174	6.7575	4	7	5
15	R:R:W182	7.86167	6	1	5
16	R:R:D186	4.43	4	0	1
17	R:R:F201	6.3	5	1	4
18	R:R:T203	5.095	4	1	4
19	R:R:Y207	5.7	6	1	7
20	R:R:F216	9.104	5	1	7
21	R:R:P219	4.21	4	0	9
22	R:R:Y227	4.90333	6	0	9
23	R:R:R229	7.125	4	2	5
24	R:R:F299	6.3425	4	1	9
25	R:R:W303	8.685	6	1	8
26	R:R:F306	8.95	5	1	7
27	R:R:F307	11.128	5	1	7
28	R:R:V309	6.0625	4	1	4
29	R:R:F328	7.0175	4	0	5
30	R:R:W330	8.115	4	1	6
31	R:R:Y333	7.29	6	1	7
32	R:R:N339	6.6625	4	4	9
33	R:R:Y343	6.28	4	0	9
34	R:R:F349	8.81333	6	3	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y333	17.1866	3.95	Yes	Yes	1	0	7
2	R:R:W330	R:R:Y333	14.021	7.72	Yes	Yes	1	6	7
3	L:L:?1	R:R:F306	59.6514	9.84	Yes	Yes	1	0	7
4	R:R:F306	R:R:W303	65.7158	7.02	Yes	Yes	1	7	8
5	R:R:N335	R:R:W303	100	6.78	No	Yes	0	9	8
6	R:R:N335	R:R:N339	98.307	5.45	No	Yes	0	9	9
7	R:R:D87	R:R:N339	65.7051	6.73	Yes	Yes	4	9	9
8	R:R:D87	R:R:S336	23.7916	11.78	Yes	No	0	9	9
9	R:R:I55	R:R:S336	14.3233	4.64	Yes	No	0	7	9
10	L:L:?1	R:R:F307	63.8094	6.56	Yes	Yes	1	0	7
11	R:R:F307	R:R:W303	50.0729	9.02	Yes	Yes	1	7	8
12	R:R:D87	R:R:N59	45.8296	8.08	Yes	No	0	9	9
13	R:R:N59	R:R:P340	44.3998	8.15	No	No	0	9	9
14	R:R:P340	R:R:V62	40.0676	3.53	No	No	0	9	9
15	R:R:C344	R:R:V62	35.6571	5.12	No	No	0	6	9
16	R:R:C344	R:R:F349	34.1775	16.76	No	Yes	0	6	8
17	R:R:F349	R:R:L72	11.2502	9.74	Yes	Yes	3	8	8
18	R:R:N339	R:R:Y343	39.0397	3.49	Yes	Yes	0	9	9
19	R:R:R139	R:R:Y343	27.0247	6.17	No	Yes	0	9	9
20	R:R:I135	R:R:R139	20	3.76	No	No	0	9	9
21	R:R:F79	R:R:I135	18.6769	3.77	Yes	No	0	8	9
22	R:R:D138	R:R:F79	15.3655	7.17	Yes	Yes	0	9	8
23	R:R:L83	R:R:N339	10.1476	10.98	Yes	Yes	4	9	9
24	R:R:L83	R:R:T131	10.923	5.9	Yes	No	0	9	8
25	L:L:?1	R:R:F201	37.1759	7.38	Yes	Yes	1	0	4
26	R:R:F201	R:R:W182	26.477	7.02	Yes	Yes	1	4	5
27	R:R:I177	R:R:W182	23.1193	7.05	No	Yes	0	6	5
28	R:R:I177	R:R:S119	20.8216	10.84	No	No	0	6	6
29	R:R:F174	R:R:S119	18.5168	11.89	Yes	No	0	5	6
30	L:L:?1	R:R:T203	36.3543	3.97	Yes	Yes	1	0	4
31	R:R:T203	R:R:W182	26.5232	3.64	Yes	Yes	1	4	5
32	L:L:?1	R:R:W117	31.6699	3.07	Yes	No	0	0	6
33	R:R:F97	R:R:W117	12.0221	10.02	No	No	0	4	6
34	R:R:F97	R:R:W109	10.7131	6.01	No	Yes	0	4	5
35	R:R:W107	R:R:W117	18.563	11.25	Yes	No	0	7	6
36	R:R:W107	R:R:W109	10.859	13.12	Yes	Yes	0	7	5
37	R:R:L108	R:R:W109	10.8234	9.11	No	Yes	0	4	5
38	R:R:F306	R:R:F325	30.0729	6.43	Yes	No	1	7	4
39	R:R:F325	R:R:N313	16.7348	6.04	No	No	1	4	4
40	R:R:N313	R:R:R317	16.1515	4.82	No	No	0	4	1
41	R:R:R183	R:R:W182	11.3676	14.99	No	Yes	1	4	5
42	R:R:F216	R:R:F307	21.7855	24.65	Yes	Yes	1	7	7
43	R:R:F216	R:R:F299	17.6774	4.29	Yes	Yes	1	7	9
44	R:R:I129	R:R:W303	23.475	8.22	No	Yes	0	8	8
45	R:R:I129	R:R:P219	20.7114	3.39	No	Yes	0	8	9
46	R:R:C133	R:R:P219	12.8864	3.77	No	Yes	0	6	9
47	R:R:C133	R:R:I222	11.3	6.55	No	No	0	6	6
48	R:R:F299	R:R:M223	22.2408	8.71	Yes	No	0	9	8
49	R:R:M223	R:R:M296	21.6575	4.33	No	No	0	8	8
50	R:R:M296	R:R:Y227	20.3735	3.59	No	Yes	0	8	9
51	R:R:V226	R:R:Y227	12.4097	2.52	No	Yes	0	6	9
52	R:R:V226	R:R:Y140	11.2004	8.83	No	Yes	0	6	8
53	R:R:P176	R:R:Y207	17.3359	2.78	No	Yes	0	7	7
54	R:R:L175	R:R:P176	13.8823	4.93	No	No	0	6	7
55	L:L:?1	R:R:S211	15.5433	10.11	Yes	No	0	0	6
56	R:R:W182	R:R:Y193	18.531	9.65	Yes	No	1	5	3
57	R:R:A189	R:R:Y193	16.3792	5.34	No	No	0	4	3
58	R:R:A189	R:R:D186	14.0601	3.09	No	Yes	0	4	1
59	R:R:L292	R:R:Y227	12.079	3.52	No	Yes	0	8	9
60	R:R:L292	R:R:Y231	10.9194	3.52	No	No	0	8	6
61	R:R:I342	R:R:Y343	12.3351	7.25	No	Yes	0	8	9
62	R:R:F325	R:R:V309	12.1963	7.87	No	Yes	1	4	4
63	R:R:F349	R:R:F353	11.2751	7.5	Yes	No	0	8	7
64	R:R:R139	R:R:Y227	11.3071	7.2	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D121	20.11	1	Yes	No	0	7	0	1
L:L:?1	R:R:V122	12.04	1	Yes	No	0	6	0	1
L:L:?1	R:R:F201	7.38	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:T203	3.97	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:S211	10.11	1	Yes	No	0	6	0	1
L:L:?1	R:R:S215	4.04	1	Yes	No	0	6	0	1
L:L:?1	R:R:F306	9.84	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F307	6.56	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N310	7.4	1	Yes	No	0	6	0	1
L:L:?1	R:R:N329	11.1	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y333	3.95	1	Yes	Yes	0	7	0	1
R:R:D121	R:R:V94	11.69	1	No	No	7	7	1	2
R:R:V94	R:R:Y333	3.79	1	No	Yes	7	7	2	1
R:R:V95	R:R:Y333	6.31	0	No	Yes	7	7	2	1
R:R:F97	R:R:W117	10.02	0	No	No	4	6	2	1
R:R:W107	R:R:W117	11.25	6	Yes	No	7	6	2	1
R:R:F201	R:R:T118	5.19	1	Yes	No	4	6	1	2
R:R:D121	R:R:Y333	10.34	1	No	Yes	7	7	1	1
R:R:S215	R:R:T126	9.59	0	No	No	6	6	1	2
R:R:F201	R:R:W182	7.02	1	Yes	Yes	4	5	1	2
R:R:T203	R:R:W182	3.64	1	Yes	Yes	4	5	1	2
R:R:W182	R:R:Y207	4.82	1	Yes	Yes	5	7	2	2
R:R:F201	R:R:T203	7.78	1	Yes	Yes	4	4	1	1
R:R:F201	R:R:Y207	4.13	1	Yes	Yes	4	7	1	2
R:R:T203	R:R:Y207	4.99	1	Yes	Yes	4	7	1	2
R:R:S211	R:R:Y207	13.99	0	No	Yes	6	7	1	2
R:R:N310	R:R:S212	4.47	1	No	No	6	6	1	2
R:R:F216	R:R:F307	24.65	1	Yes	Yes	7	7	2	1
R:R:F306	R:R:W303	7.02	1	Yes	Yes	7	8	1	2
R:R:F307	R:R:W303	9.02	1	Yes	Yes	7	8	1	2
R:R:F306	R:R:F307	11.79	1	Yes	Yes	7	7	1	1
R:R:F306	R:R:F325	6.43	1	Yes	No	7	4	1	2
R:R:F306	R:R:N329	9.67	1	Yes	No	7	6	1	1
R:R:F307	R:R:N310	3.62	1	Yes	No	7	6	1	1
R:R:N329	R:R:Y333	11.63	1	No	Yes	6	7	1	1
R:R:W330	R:R:Y333	7.72	1	Yes	Yes	6	7	2	1
L:L:?1	R:R:W117	3.07	1	Yes	No	0	6	0	1
L:L:?1	R:R:A208	2.12	1	Yes	No	0	6	0	1
R:R:A208	R:R:V314	1.7	0	No	No	6	5	1	2
R:R:S211	R:R:V172	1.62	0	No	Yes	6	5	1	2
R:R:S215	R:R:V172	1.62	0	No	Yes	6	5	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8DCS_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.49
Number of Linked Nodes	248
Number of Links	279
Number of Hubs	34
Number of Links mediated by Hubs	137
Number of Communities	8
Number of Nodes involved in Communities	50
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	65
Number Of Links MetaPath	64
Number of Shortest Paths	58180
Length Of Smallest Path	3
Average Path Length	12.2312
Length of Longest Path	23
Minimum Path Strength	1.44
Average Path Strength	6.56906
Maximum Path Strength	23.285
Minimum Path Correlation	0.7
Average Path Correlation	0.919848
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	48.3272
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.0877
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein-containing complex binding • binding • protein binding • enzyme binding • GTPase binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus
Gene Ontology	Biological Process	• cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • cellular process • signal transduction • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle • organelle membrane • synapse • cell junction • intracellular anatomical structure • cytoplasm • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • G-protein beta-subunit binding • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta1-adrenergic receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • identical protein binding • hydrolase activity, acting on glycosyl bonds • peptidoglycan muralytic activity • hydrolase activity, hydrolyzing O-glycosyl compounds • lysozyme activity • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • behavior • circadian behavior • regulation of multicellular organismal process • sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • heart process • regulation of heart contraction • regulation of system process • positive regulation of blood circulation • positive regulation of heart contraction • regulation of blood circulation • positive regulation of multicellular organismal process • heart contraction • biological process involved in interspecies interaction between organisms • response to other organism • defense response • response to external stimulus • response to biotic stimulus • defense response to bacterium • defense response to other organism • response to stress • response to bacterium • response to external biotic stimulus • carbohydrate derivative catabolic process • catabolic process • peptidoglycan catabolic process • glycosaminoglycan metabolic process • carbohydrate derivative metabolic process • aminoglycan catabolic process • macromolecule catabolic process • glycosaminoglycan catabolic process • aminoglycan metabolic process • peptidoglycan metabolic process • metabolic process • macromolecule metabolic process • symbiont-mediated cytolysis of host cell • viral life cycle • disruption of cell in another organism • cytolysis • biological process involved in interaction with host • biological process involved in symbiotic interaction • viral release from host cell by cytolysis • exit from host cell • viral process • cytolysis in another organism • viral release from host cell • disruption of anatomical structure in another organism • symbiont-mediated killing of host cell • killing of cells of another organism • cell killing • cell wall organization or biogenesis • cell wall macromolecule catabolic process • cell wall macromolecule metabolic process • early endosome • endosome • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle • vesicle • host cellular component • host intracellular part • host cell cytoplasm • host cell part • host intracellular region
SCOP2	Domain Identifier	• WD40 repeat-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
SCOP2	Family Identifier	• WD40 repeat-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	P32
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	P32
Name	4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
Synonyms	4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile
Identifier
Formula	C16 H21 N3 O2
Molecular Weight	287.357
SMILES
PubChem	46937143
Formal Charge	0
Total Atoms	42
Total Chiral Atoms	1
Total Bonds	43
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07700
Sequence	>8DCS_nogp_Chain_R M S L L M A L V V L L I V A G N V L V I A A I G S T Q R L Q T L T N L F I T S L A C A D L V V G L L V V P F G A T L V V R G T W L W G S F L C E L W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S P F R Y Q S L M T R A R A K V I I C T V W A I S A L V S F L P I M M H W W R D E D P Q A L K C Y Q D P G C C D F V T N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R F R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N R D L V P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F R K A F K R L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8DCS	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	Gs/β1/γ2	2.5	2022-07-27	10.1038/s41467-022-31823-1
	8DCS (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-		2.5	2022-07-27	10.1038/s41467-022-31823-1
	8DCR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	Gs/β1/γ2	2.6	2022-07-27	10.1038/s41467-022-31823-1
	8DCR (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-		2.6	2022-07-27	10.1038/s41467-022-31823-1
	7S0G	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	chim(Gi1-CtGs)/β1/γ2	3.86	2021-11-17	10.1038/s41594-021-00679-2
	7S0G (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		3.86	2021-11-17	10.1038/s41594-021-00679-2
	7S0F	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gi1/β1/γ2	2.96	2021-11-17	10.1038/s41594-021-00679-2
	7S0F (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.96	2021-11-17	10.1038/s41594-021-00679-2
	7BVQ	A	Amine	Adrenergic	β₁	Homo sapiens	S-Carazolol	-	-	2.5	2020-12-02	10.1038/s41422-020-00424-2
	7BU7	A	Amine	Adrenergic	β₁	Homo sapiens	BI167107	-	-	2.6	2020-12-02	10.1038/s41422-020-00424-2
	7BU6	A	Amine	Adrenergic	β₁	Homo sapiens	L-Norepinephrine	-	-	2.7	2020-12-02	10.1038/s41422-020-00424-2
	7BTS	A	Amine	Adrenergic	β₁	Homo sapiens	L-Epinephrine	-	-	3.13	2020-12-02	10.1038/s41422-020-00424-2
	7JJO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gs/β1/γ2	2.6	2020-09-02	10.1016/j.molcel.2020.08.001
	7JJO (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.6	2020-09-02	10.1016/j.molcel.2020.08.001
	6TKO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	Arrestin2	3.3	2020-06-17	10.1038/s41586-020-2419-1
	6IBL	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	-	2.7	2019-01-09	10.1038/s41586-020-2419-1
	6H7O	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.8	2018-10-17	10.1126/science.aau5595
	6H7N	A	Amine	Adrenergic	β₁	Meleagris gallopavo	S-Xamoterol	-	-	2.5	2018-10-17	10.1101/436212
	6H7M	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	2.76	2018-10-17	10.1126/science.aau5595
	6H7L	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.7	2018-10-17	10.1126/science.aau5595
	6H7J	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.8	2018-10-17	10.1126/science.aau5595
	5F8U	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.35	2015-12-23	10.1038/nsmb.3130
	5A8E	A	Amine	Adrenergic	β₁	Meleagris gallopavo	7-Methylcyanopindolol	Na	-	2.4	2015-09-30	10.1124/mol.115.101030
	4BVN	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	Na	-	2.1	2014-04-02	10.1371/journal.pone.0092727
	3ZPR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	4-methyl-2-(piperazin-1-yl)	Na	-	2.7	2013-04-03	10.1021/jm400140q
	3ZPQ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	4-(piperazin-1- yl)-1H-indole	Na	-	2.8	2013-04-03	10.1021/jm400140q
	4GPO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	-	-	-	3.5	2013-02-27	10.1038/nsmb.2504
	4GPO (Multimeric)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	-	-		3.5	2013-02-27	10.1038/nsmb.2504
	4AMJ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	S-Carvedilol	-	-	2.3	2012-05-23	10.1016/j.str.2012.03.014
	4AMI	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Bucindolol	-	-	3.2	2012-05-23	10.1016/j.str.2012.03.014
	2YCY	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.15	2011-06-08	10.1073/pnas.1100185108
	2YCZ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Iodocyanopindolol	-	-	3.65	2011-06-01	10.1073/pnas.1100185108
	2YCX	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.25	2011-06-01	10.1073/pnas.1100185108
	2YCW	A	Amine	Adrenergic	β₁	Meleagris gallopavo	S-Carazolol	-	-	3	2011-06-01	10.1073/pnas.1100185108
	2Y01	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.6	2011-03-30	10.1038/nature09746
	2Y04	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	3.05	2011-01-12	10.1038/nature09746
	2Y03	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.85	2011-01-12	10.1038/nature09746
	2Y02	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carmoterol	-	-	2.6	2011-01-12	10.1038/nature09746
	2Y00	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.5	2011-01-12	10.1038/nature09746
	2VT4	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.7	2008-06-24	10.1038/nature07101

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