psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W117	5.56	Yes	Yes	0	0	6
2	L:L:?1	R:R:D121	22.08	Yes	Yes	1	0	7
3	L:L:?1	R:R:V122	10.9	Yes	No	0	0	6
4	L:L:?1	R:R:V125	6.06	Yes	No	1	0	6
5	L:L:?1	R:R:F201	20.8	Yes	No	0	0	4
6	L:L:?1	R:R:S211	8.55	Yes	No	0	0	6
7	L:L:?1	R:R:F306	7.92	Yes	Yes	1	0	7
8	L:L:?1	R:R:F307	4.95	Yes	Yes	1	0	7
9	L:L:?1	R:R:N310	4.47	Yes	No	0	0	6
10	L:L:?1	R:R:N329	10.05	Yes	No	1	0	6
11	L:L:?1	R:R:Y333	8.58	Yes	Yes	1	0	7
12	R:R:E41	R:R:V103	7.13	No	No	0	5	5
13	R:R:L47	R:R:M44	4.24	No	No	0	5	4
14	R:R:L46	R:R:S45	4.5	No	No	0	4	5
15	R:R:A99	R:R:M48	6.44	No	No	0	6	6
16	R:R:V52	R:R:V95	6.41	No	No	5	5	7
17	R:R:P96	R:R:V52	3.53	No	No	5	9	5
18	R:R:A337	R:R:L54	3.15	No	No	0	6	5
19	R:R:D87	R:R:I55	7	No	Yes	6	9	7
20	R:R:I55	R:R:S336	4.64	Yes	No	6	7	9
21	R:R:A84	R:R:N59	3.13	No	No	0	8	9
22	R:R:D87	R:R:N59	10.77	No	No	0	9	9
23	R:R:L88	R:R:N59	19.22	No	No	0	7	9
24	R:R:L88	R:R:V60	4.47	No	No	0	7	3
25	R:R:A84	R:R:V62	3.39	No	No	0	8	9
26	R:R:C344	R:R:V62	6.83	No	No	0	6	9
27	R:R:A84	R:R:I63	3.25	No	No	0	8	7
28	R:R:C85	R:R:I63	4.91	No	No	0	5	7
29	R:R:I66	R:R:N77	8.5	No	Yes	4	7	9
30	R:R:I66	R:R:T81	6.08	No	No	0	7	5
31	R:R:F349	R:R:I66	5.02	Yes	No	4	8	7
32	R:R:L72	R:R:T69	7.37	Yes	No	0	8	6
33	R:R:L72	R:R:N77	4.12	Yes	Yes	4	8	9
34	R:R:F349	R:R:L72	7.31	Yes	Yes	4	8	8
35	R:R:A352	R:R:L72	3.15	No	Yes	0	7	8
36	R:R:N77	R:R:T74	7.31	Yes	No	0	9	7
37	R:R:L75	R:R:Y149	4.69	No	Yes	7	6	7
38	R:R:L75	R:R:M153	5.65	No	No	7	6	6
39	R:R:D138	R:R:T76	4.34	No	No	0	9	8
40	R:R:F349	R:R:N77	7.25	Yes	Yes	4	8	9
41	R:R:K159	R:R:L78	7.05	No	No	0	4	5
42	R:R:I162	R:R:L78	4.28	No	No	0	7	5
43	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
44	R:R:D138	R:R:F79	4.78	No	Yes	0	9	8
45	R:R:F79	R:R:I162	5.02	Yes	No	0	8	7
46	R:R:I80	R:R:Y343	3.63	No	Yes	0	7	9
47	R:R:S82	R:R:T131	4.8	No	No	0	9	8
48	R:R:S82	R:R:W166	4.94	No	No	0	9	9
49	R:R:L83	R:R:T131	5.9	No	No	0	9	8
50	R:R:L83	R:R:N339	5.49	No	No	0	9	9
51	R:R:D87	R:R:S336	5.89	No	No	6	9	9
52	R:R:C124	R:R:V89	3.42	No	No	0	6	6
53	R:R:G91	R:R:V90	3.68	No	No	0	7	8
54	R:R:C124	R:R:V90	3.42	No	No	0	6	8
55	R:R:S336	R:R:V90	3.23	No	No	0	9	8
56	R:R:G91	R:R:V95	3.68	No	No	0	7	7
57	R:R:L92	R:R:L93	6.92	No	No	0	5	4
58	R:R:V94	R:R:W117	6.13	No	Yes	0	7	6
59	R:R:D121	R:R:V94	5.84	Yes	No	1	7	7
60	R:R:V94	R:R:Y333	3.79	No	Yes	1	7	7
61	R:R:P96	R:R:V95	3.53	No	No	5	9	7
62	R:R:F97	R:R:W109	4.01	No	Yes	0	4	5
63	R:R:F97	R:R:W117	9.02	No	Yes	0	4	6
64	R:R:G98	R:R:W117	4.22	No	Yes	0	6	6
65	R:R:T100	R:R:W109	8.49	No	Yes	0	4	5
66	R:R:L101	R:R:W107	6.83	No	Yes	0	5	7
67	R:R:L108	R:R:R104	4.86	No	No	0	4	4
68	R:R:W107	R:R:W109	22.49	Yes	Yes	3	7	5
69	R:R:L113	R:R:W107	4.56	No	Yes	3	4	7
70	R:R:C114	R:R:W107	7.84	No	Yes	3	9	7
71	R:R:W107	R:R:W117	14.99	Yes	Yes	0	7	6
72	R:R:C199	R:R:W107	19.59	No	Yes	3	9	7
73	R:R:L108	R:R:W109	20.5	No	Yes	0	4	5
74	R:R:L113	R:R:W109	11.39	No	Yes	3	4	5
75	R:R:C114	R:R:C199	7.28	No	No	3	9	9
76	R:R:E115	R:R:H180	6.15	No	No	2	6	5
77	R:R:E115	R:R:R183	4.65	No	Yes	2	6	4
78	R:R:F174	R:R:S119	3.96	Yes	No	0	5	6
79	R:R:I177	R:R:S119	9.29	No	No	0	6	6
80	R:R:D121	R:R:V125	4.38	Yes	No	1	7	6
81	R:R:D121	R:R:Y333	11.49	Yes	Yes	1	7	7
82	R:R:S173	R:R:V122	3.23	No	No	0	7	6
83	R:R:V122	R:R:Y207	3.79	No	Yes	0	6	7
84	R:R:C124	R:R:L123	3.17	No	Yes	0	6	5
85	R:R:L123	R:R:S169	6.01	Yes	No	0	5	8
86	R:R:L123	R:R:S173	6.01	Yes	No	8	5	7
87	R:R:F174	R:R:L123	6.09	Yes	Yes	8	5	5
88	R:R:V125	R:R:W303	9.81	No	Yes	1	6	8
89	R:R:E130	R:R:T126	5.64	No	Yes	0	6	6
90	R:R:S169	R:R:T126	3.2	No	Yes	0	8	6
91	R:R:S215	R:R:T126	9.59	No	Yes	0	6	6
92	R:R:I129	R:R:P219	3.39	No	No	0	8	9
93	R:R:F299	R:R:I129	5.02	No	No	0	9	8
94	R:R:I129	R:R:W303	8.22	No	Yes	0	8	8
95	R:R:E130	R:R:V165	8.56	No	No	0	6	6
96	R:R:L132	R:R:N339	8.24	No	No	0	8	9
97	R:R:L132	R:R:Y343	4.69	No	Yes	0	8	9
98	R:R:C133	R:R:P219	3.77	No	No	0	6	9
99	R:R:A136	R:R:Y227	5.34	No	Yes	0	8	9
100	R:R:D138	R:R:Y149	12.64	No	Yes	0	9	7
101	R:R:R139	R:R:Y343	6.17	No	Yes	0	9	9
102	R:R:T144	R:R:Y140	11.24	No	Yes	9	7	8
103	R:R:V226	R:R:Y140	6.31	No	Yes	0	6	8
104	R:R:R229	R:R:Y140	6.17	Yes	Yes	9	5	8
105	R:R:A142	R:R:Y149	8.01	No	Yes	0	8	7
106	R:R:S145	R:R:T144	4.8	No	No	0	6	7
107	R:R:R229	R:R:T144	3.88	Yes	No	9	5	7
108	R:R:F147	R:R:P146	5.78	No	No	0	6	8
109	R:R:M153	R:R:Y149	11.97	No	Yes	7	6	7
110	R:R:L152	R:R:S151	4.5	No	No	0	5	5
111	R:R:R157	R:R:T154	5.17	No	No	0	7	8
112	R:R:F174	R:R:S173	5.28	Yes	No	8	5	7
113	R:R:P176	R:R:Y207	4.17	No	Yes	0	7	7
114	R:R:I177	R:R:W182	5.87	No	Yes	2	6	5
115	R:R:I177	R:R:Y207	3.63	No	Yes	2	6	7
116	R:R:M179	R:R:W181	18.61	No	No	0	5	6
117	R:R:H180	R:R:R183	13.54	No	Yes	2	5	4
118	R:R:R183	R:R:W182	9	Yes	Yes	2	4	5
119	R:R:W182	R:R:Y193	8.68	Yes	Yes	2	5	3
120	R:R:T203	R:R:W182	3.64	Yes	Yes	2	4	5
121	R:R:W182	R:R:Y207	3.86	Yes	Yes	2	5	7
122	R:R:R183	R:R:Y193	20.58	Yes	Yes	2	4	3
123	R:R:D184	R:R:D186	5.32	No	No	0	4	1
124	R:R:A189	R:R:D184	4.63	No	No	0	4	4
125	R:R:D186	R:R:P187	8.05	No	No	0	1	1
126	R:R:D186	R:R:Q188	3.92	No	No	0	1	2
127	R:R:Q188	R:R:V202	4.3	No	No	0	2	4
128	R:R:A189	R:R:Y193	5.34	No	Yes	0	4	3
129	R:R:C192	R:R:C198	7.28	No	No	0	4	5
130	R:R:D195	R:R:P196	4.83	No	No	0	3	3
131	R:R:D195	R:R:G197	5.03	No	No	0	3	4
132	R:R:C198	R:R:D195	4.67	No	No	0	5	3
133	R:R:C198	R:R:D200	4.67	No	No	0	5	5
134	R:R:N204	R:R:T203	4.39	No	Yes	2	5	4
135	R:R:T203	R:R:Y207	4.99	Yes	Yes	2	4	7
136	R:R:A208	R:R:T203	3.36	No	Yes	0	6	4
137	R:R:N204	R:R:Y207	4.65	No	Yes	2	5	7
138	R:R:R205	R:R:V314	9.15	No	No	0	5	5
139	R:R:S211	R:R:Y207	3.82	No	Yes	0	6	7
140	R:R:F307	R:R:S212	5.28	Yes	No	0	7	6
141	R:R:F216	R:R:Y217	8.25	Yes	No	0	7	5
142	R:R:F216	R:R:L220	3.65	Yes	No	0	7	6
143	R:R:F216	R:R:F299	5.36	Yes	No	0	7	9
144	R:R:F216	R:R:W303	4.01	Yes	Yes	1	7	8
145	R:R:F216	R:R:L304	7.31	Yes	Yes	0	7	7
146	R:R:F216	R:R:F307	18.22	Yes	Yes	1	7	7
147	R:R:I311	R:R:Y217	6.04	No	No	0	5	5
148	R:R:I218	R:R:P219	3.39	No	No	0	5	9
149	R:R:I224	R:R:L220	7.14	No	No	0	5	6
150	R:R:M223	R:R:Y227	3.59	No	Yes	0	8	9
151	R:R:I224	R:R:M296	4.37	No	No	0	5	8
152	R:R:L292	R:R:Y227	3.52	No	Yes	0	8	9
153	R:R:M296	R:R:Y227	3.59	No	Yes	0	8	9
154	R:R:R229	R:R:R232	8.53	Yes	No	0	5	4
155	R:R:E233	R:R:R229	3.49	No	Yes	0	6	5
156	R:R:L289	R:R:Y231	8.21	No	No	0	7	6
157	R:R:L292	R:R:Y231	3.52	No	No	0	8	6
158	R:R:E285	R:R:H286	4.92	No	No	0	7	5
159	R:R:I295	R:R:Y343	6.04	No	Yes	0	8	9
160	R:R:C302	R:R:N335	3.15	No	No	0	8	9
161	R:R:F306	R:R:W303	6.01	Yes	Yes	1	7	8
162	R:R:F307	R:R:W303	5.01	Yes	Yes	1	7	8
163	R:R:G332	R:R:W303	9.85	No	Yes	0	6	8
164	R:R:N335	R:R:W303	9.04	No	Yes	0	9	8
165	R:R:L304	R:R:P305	3.28	Yes	No	0	7	9
166	R:R:L304	R:R:L308	6.92	Yes	No	0	7	6
167	R:R:F328	R:R:P305	11.56	Yes	No	0	5	9
168	R:R:F306	R:R:F307	5.36	Yes	Yes	1	7	7
169	R:R:F306	R:R:F325	11.79	Yes	No	0	7	4
170	R:R:F306	R:R:N329	13.29	Yes	No	1	7	6
171	R:R:N313	R:R:V309	4.43	No	No	0	4	4
172	R:R:V309	R:R:V320	6.41	No	No	0	4	5
173	R:R:F328	R:R:V309	3.93	Yes	No	0	5	4
174	R:R:N313	R:R:R317	3.62	No	No	0	4	1
175	R:R:F325	R:R:N313	4.83	No	No	0	4	4
176	R:R:L319	R:R:N316	5.49	No	No	0	6	4
177	R:R:D322	R:R:R317	5.96	No	No	0	3	1
178	R:R:P321	R:R:V320	3.53	No	No	0	5	5
179	R:R:P321	R:R:W323	6.76	No	No	0	5	3
180	R:R:L324	R:R:W323	3.42	No	No	0	4	3
181	R:R:F328	R:R:L324	6.09	Yes	No	0	5	4
182	R:R:F327	R:R:F328	4.29	No	Yes	0	5	5
183	R:R:N329	R:R:Y333	16.28	No	Yes	1	6	7
184	R:R:W330	R:R:Y333	3.86	No	Yes	0	6	7
185	R:R:N335	R:R:N339	14.98	No	No	0	9	9
186	R:R:I342	R:R:Y343	4.84	No	Yes	0	8	9
187	R:R:C344	R:R:F349	12.57	No	Yes	0	6	8
188	R:R:P347	R:R:S346	3.56	No	No	0	6	8
189	R:R:F353	R:R:R350	4.28	No	No	0	7	8
190	R:R:I162	R:R:S82	3.1	No	No	0	7	9
191	R:R:I55	R:R:V51	3.07	Yes	No	0	7	6
192	R:R:I168	R:R:T164	3.04	No	No	0	4	3
193	R:R:K287	R:R:T291	3	No	No	0	8	8
194	R:R:L47	R:R:V51	2.98	No	No	0	5	6
195	R:R:L88	R:R:V56	2.98	No	No	0	7	6
196	R:R:L304	R:R:T300	2.95	Yes	No	0	7	5
197	R:R:I137	R:R:I222	2.94	No	No	0	6	6
198	R:R:I218	R:R:I222	2.94	No	No	0	5	6
199	R:R:I294	R:R:I342	2.94	No	No	0	7	8
200	R:R:I294	R:R:K290	2.91	No	No	0	7	7
201	R:R:I137	R:R:L141	2.85	No	No	0	6	5
202	R:R:G110	R:R:W107	2.81	No	Yes	0	7	7
203	R:R:C302	R:R:F338	2.79	No	No	0	8	6
204	R:R:A158	R:R:F79	2.77	No	Yes	0	7	8
205	R:R:L120	R:R:L93	2.77	No	No	0	5	4
206	R:R:L113	R:R:L116	2.77	No	No	0	4	4
207	R:R:L116	R:R:L120	2.77	No	No	0	4	5
208	R:R:A170	R:R:F174	2.77	No	Yes	0	3	5
209	R:R:A334	R:R:F338	2.77	No	No	0	4	6
210	R:R:E130	R:R:I168	2.73	No	No	0	6	4
211	R:R:D348	R:R:L72	2.71	No	Yes	0	6	8
212	R:R:R148	R:R:S145	2.64	No	No	0	5	6
213	R:R:F79	R:R:V134	2.62	Yes	No	0	8	5
214	R:R:F338	R:R:V298	2.62	No	No	0	6	6
215	R:R:F315	R:R:V314	2.62	No	No	0	5	5
216	R:R:R71	R:R:T69	2.59	No	No	0	5	6
217	R:R:A99	R:R:W330	2.59	No	No	0	6	6
218	R:R:F201	R:R:T118	2.59	No	No	0	4	6
219	R:R:A127	R:R:W166	2.59	No	No	0	7	9
220	R:R:Q70	R:R:Q73	2.56	No	No	0	6	7
221	R:R:V230	R:R:Y140	2.52	No	Yes	0	9	8
222	R:R:V226	R:R:Y227	2.52	No	Yes	0	6	9
223	R:R:I209	R:R:R205	2.51	No	No	0	5	5
224	R:R:V326	R:R:W330	2.45	No	No	0	4	6
225	R:R:F112	R:R:L116	2.44	No	No	0	2	4
226	R:R:F315	R:R:N316	2.42	No	No	0	5	4
227	R:R:A57	R:R:G58	1.95	No	No	0	4	8
228	R:R:G297	R:R:T300	1.82	No	No	0	5	5
229	R:R:A352	R:R:A65	1.79	No	No	0	7	7
230	R:R:A127	R:R:A86	1.79	No	No	0	7	8
231	R:R:A234	R:R:A288	1.79	No	No	0	8	8
232	R:R:P146	R:R:S145	1.78	No	No	0	8	6
233	R:R:P340	R:R:V62	1.77	No	No	0	9	9
234	R:R:G58	R:R:L61	1.71	No	No	0	8	6
235	R:R:G332	R:R:L331	1.71	No	No	0	6	7
236	R:R:A208	R:R:V314	1.7	No	No	0	6	5
237	R:R:A156	R:R:T154	1.68	No	No	0	5	8
238	R:R:L175	R:R:P176	1.64	No	No	0	6	7
239	R:R:A337	R:R:I55	1.62	No	Yes	0	6	7
240	R:R:A49	R:R:M48	1.61	No	No	0	4	6
241	R:R:S68	R:R:T69	1.6	No	No	0	5	6
242	R:R:V102	R:R:V103	1.6	No	No	0	5	5
243	R:R:V312	R:R:V320	1.6	No	No	0	5	5
244	R:R:T126	R:R:V172	1.59	Yes	No	0	6	5
245	R:R:T164	R:R:V160	1.59	No	No	0	3	3
246	R:R:A65	R:R:L356	1.58	No	No	0	7	6
247	R:R:A189	R:R:L190	1.58	No	No	0	4	1
248	R:R:A206	R:R:N204	1.56	No	No	0	4	5
249	R:R:I161	R:R:V134	1.54	No	No	0	6	5
250	R:R:I143	R:R:V230	1.54	No	No	0	9	9
251	R:R:I214	R:R:V172	1.54	No	No	0	4	5
252	R:R:M48	R:R:S45	1.53	No	No	0	6	5
253	R:R:C192	R:R:Q188	1.53	No	No	0	4	2
254	R:R:I295	R:R:T291	1.52	No	No	0	8	8
255	R:R:L83	R:R:S128	1.5	No	No	0	9	9
256	R:R:I209	R:R:I213	1.47	No	No	0	5	4
257	R:R:I213	R:R:I214	1.47	No	No	0	4	4
258	R:R:M178	R:R:M179	1.44	No	No	0	4	5
259	R:R:I224	R:R:L228	1.43	No	No	0	5	2
260	R:R:K240	R:R:Q237	1.36	No	No	0	5	7
261	R:R:P176	R:R:W181	1.35	No	No	0	7	6
262	R:R:R104	R:R:V103	1.31	No	No	0	4	5
263	R:R:F225	R:R:V226	1.31	No	No	0	5	6
264	R:R:H286	R:R:L289	1.29	No	No	0	5	7
265	R:R:R345	R:R:T291	1.29	No	No	0	7	8
266	R:R:E233	R:R:E236	1.27	No	No	0	6	4
267	R:R:K354	R:R:R355	1.24	No	No	0	4	4
268	R:R:F353	R:R:L61	1.22	No	No	0	7	6
269	R:R:L78	R:R:R155	1.21	No	No	0	5	3
270	R:R:L356	R:R:R355	1.21	No	No	0	6	4
271	R:R:Q70	R:R:R71	1.17	No	No	0	6	5
272	R:R:Q194	R:R:Y193	1.13	No	Yes	0	3	3
273	R:R:R345	R:R:R350	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.99273	11	1	0
2	R:R:I55	4.0825	4	6	7
3	R:R:L72	4.932	5	4	8
4	R:R:N77	6.795	4	4	9
5	R:R:F79	3.792	5	0	8
6	R:R:W107	11.3014	7	3	7
7	R:R:W109	13.376	5	3	5
8	R:R:W117	7.984	5	0	6
9	R:R:D121	10.9475	4	1	7
10	R:R:L123	5.32	4	8	5
11	R:R:T126	5.005	4	0	6
12	R:R:Y140	6.56	4	9	8
13	R:R:Y149	9.3275	4	7	7
14	R:R:F174	4.525	4	8	5
15	R:R:W182	6.21	5	2	5
16	R:R:R183	11.9425	4	2	4
17	R:R:Y193	8.9325	4	2	3
18	R:R:T203	4.095	4	2	4
19	R:R:Y207	4.13	7	2	7
20	R:R:F216	7.8	6	1	7
21	R:R:Y227	3.712	5	0	9
22	R:R:R229	5.5175	4	9	5
23	R:R:W303	7.42143	7	1	8
24	R:R:L304	5.115	4	0	7
25	R:R:F306	8.874	5	1	7
26	R:R:F307	7.764	5	1	7
27	R:R:F328	6.4675	4	0	5
28	R:R:Y333	8.8	5	1	7
29	R:R:Y343	5.074	5	0	9
30	R:R:F349	8.0375	4	4	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:W117	39.0983	5.56	Yes	Yes	0	0	6
2	R:R:F97	R:R:W117	11.4122	9.02	No	Yes	0	4	6
3	R:R:F97	R:R:W109	10.0156	4.01	No	Yes	0	4	5
4	R:R:L108	R:R:W109	14.3952	20.5	No	Yes	0	4	5
5	R:R:L108	R:R:R104	11.4729	4.86	No	No	0	4	4
6	R:R:W107	R:R:W117	25.6746	14.99	Yes	Yes	0	7	6
7	R:R:W107	R:R:W109	10.0991	22.49	Yes	Yes	3	7	5
8	L:L:?1	R:R:V122	96.3262	10.9	Yes	No	0	0	6
9	R:R:S173	R:R:V122	65.1714	3.23	No	No	0	7	6
10	R:R:L123	R:R:S173	61.0991	6.01	Yes	No	8	5	7
11	R:R:C124	R:R:L123	53.6795	3.17	No	Yes	0	6	5
12	R:R:C124	R:R:V90	51.4175	3.42	No	No	0	6	8
13	R:R:S336	R:R:V90	45.6298	3.23	No	No	0	9	8
14	L:L:?1	R:R:Y333	12.2471	8.58	Yes	Yes	1	0	7
15	R:R:W330	R:R:Y333	14.1372	3.86	No	Yes	0	6	7
16	R:R:A99	R:R:W330	10.0687	2.59	No	No	0	6	6
17	R:R:D87	R:R:S336	36.5706	5.89	No	No	6	9	9
18	R:R:D87	R:R:N59	35.9748	10.77	No	No	0	9	9
19	R:R:A84	R:R:N59	30.9651	3.13	No	No	0	8	9
20	R:R:A84	R:R:V62	27.1282	3.39	No	No	0	8	9
21	R:R:C344	R:R:V62	24.5247	6.83	No	No	0	6	9
22	R:R:C344	R:R:F349	23.3064	12.57	No	Yes	0	6	8
23	R:R:F349	R:R:L72	16.6648	7.31	Yes	Yes	4	8	8
24	L:L:?1	R:R:V125	36.2367	6.06	Yes	No	1	0	6
25	R:R:V125	R:R:W303	38.2443	9.81	No	Yes	1	6	8
26	R:R:N335	R:R:W303	100	9.04	No	Yes	0	9	8
27	R:R:N335	R:R:N339	89.1837	14.98	No	No	0	9	9
28	R:R:L83	R:R:N339	51.9792	5.49	No	No	0	9	9
29	R:R:L83	R:R:T131	47.3415	5.9	No	No	0	9	8
30	R:R:S82	R:R:T131	45.0112	4.8	No	No	0	9	8
31	R:R:I162	R:R:S82	35.6143	3.1	No	No	0	7	9
32	R:R:F79	R:R:I162	26.316	5.02	Yes	No	0	8	7
33	R:R:D138	R:R:F79	14.2169	4.78	No	Yes	0	9	8
34	L:L:?1	R:R:F306	45.1516	7.92	Yes	Yes	1	0	7
35	R:R:F306	R:R:W303	40.0053	6.01	Yes	Yes	1	7	8
36	L:L:?1	R:R:F307	63.5584	4.95	Yes	Yes	1	0	7
37	R:R:F307	R:R:W303	35.971	5.01	Yes	Yes	1	7	8
38	R:R:L132	R:R:N339	37.5802	8.24	No	No	0	8	9
39	R:R:L132	R:R:Y343	35.1968	4.69	No	Yes	0	8	9
40	R:R:V122	R:R:Y207	44.5254	3.79	No	Yes	0	6	7
41	R:R:W182	R:R:Y207	42.2141	3.86	Yes	Yes	2	5	7
42	L:L:?1	R:R:S211	38.6314	8.55	Yes	No	0	0	6
43	R:R:S211	R:R:Y207	37.7889	3.82	No	Yes	0	6	7
44	R:R:L123	R:R:S169	15.1049	6.01	Yes	No	0	5	8
45	R:R:S169	R:R:T126	13.7766	3.2	No	Yes	0	8	6
46	R:R:I129	R:R:W303	17.3175	8.22	No	Yes	0	8	8
47	R:R:I129	R:R:P219	15.5717	3.39	No	No	0	8	9
48	R:R:F216	R:R:F307	27.6519	18.22	Yes	Yes	1	7	7
49	R:R:F216	R:R:L220	27.1358	3.65	Yes	No	0	7	6
50	R:R:I224	R:R:L220	26.1794	7.14	No	No	0	5	6
51	R:R:I224	R:R:M296	24.24	4.37	No	No	0	5	8
52	R:R:M296	R:R:Y227	23.2533	3.59	No	Yes	0	8	9
53	R:R:V226	R:R:Y227	15.3516	2.52	No	Yes	0	6	9
54	R:R:V226	R:R:Y140	13.2491	6.31	No	Yes	0	6	8
55	R:R:P176	R:R:Y207	11.7614	4.17	No	Yes	0	7	7
56	R:R:W182	R:R:Y193	37.4435	8.68	Yes	Yes	2	5	3
57	R:R:T203	R:R:Y207	19.3859	4.99	Yes	Yes	2	4	7
58	R:R:A189	R:R:Y193	32.7071	5.34	No	Yes	0	4	3
59	R:R:A189	R:R:D184	27.7582	4.63	No	No	0	4	4
60	R:R:D184	R:R:D186	25.2723	5.32	No	No	0	4	1
61	R:R:D186	R:R:Q188	20.2778	3.92	No	No	0	1	2
62	R:R:C192	R:R:Q188	15.253	1.53	No	No	0	4	2
63	R:R:C192	R:R:C198	12.7291	7.28	No	No	0	4	5
64	R:R:A208	R:R:T203	18.2777	3.36	No	Yes	0	6	4
65	R:R:A208	R:R:V314	16.0082	1.7	No	No	0	6	5
66	R:R:F216	R:R:L304	10.118	7.31	Yes	Yes	0	7	7
67	R:R:I218	R:R:P219	10.4103	3.39	No	No	0	5	9
68	R:R:I295	R:R:Y343	21.2949	6.04	No	Yes	0	8	9
69	R:R:F306	R:R:F325	12.1371	11.79	Yes	No	0	7	4
70	R:R:F325	R:R:N313	10.9795	4.83	No	No	0	4	4
71	R:R:I295	R:R:T291	19.1089	1.52	No	No	0	8	8
72	R:R:R345	R:R:T291	14.4901	1.29	No	No	0	7	8
73	R:R:R345	R:R:R350	12.0612	1.07	No	No	0	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:W117	5.56	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:D121	22.08	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V122	10.9	1	Yes	No	0	6	0	1
L:L:?1	R:R:V125	6.06	1	Yes	No	0	6	0	1
L:L:?1	R:R:F201	20.8	1	Yes	No	0	4	0	1
L:L:?1	R:R:S211	8.55	1	Yes	No	0	6	0	1
L:L:?1	R:R:F306	7.92	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F307	4.95	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N310	4.47	1	Yes	No	0	6	0	1
L:L:?1	R:R:N329	10.05	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y333	8.58	1	Yes	Yes	0	7	0	1
R:R:V94	R:R:W117	6.13	1	No	Yes	7	6	2	1
R:R:D121	R:R:V94	5.84	1	Yes	No	7	7	1	2
R:R:V94	R:R:Y333	3.79	1	No	Yes	7	7	2	1
R:R:F97	R:R:W117	9.02	0	No	Yes	4	6	2	1
R:R:G98	R:R:W117	4.22	0	No	Yes	6	6	2	1
R:R:W107	R:R:W117	14.99	3	Yes	Yes	7	6	2	1
R:R:D121	R:R:V125	4.38	1	Yes	No	7	6	1	1
R:R:D121	R:R:Y333	11.49	1	Yes	Yes	7	7	1	1
R:R:S173	R:R:V122	3.23	8	No	No	7	6	2	1
R:R:V122	R:R:Y207	3.79	0	No	Yes	6	7	1	2
R:R:V125	R:R:W303	9.81	1	No	Yes	6	8	1	2
R:R:S211	R:R:Y207	3.82	0	No	Yes	6	7	1	2
R:R:F307	R:R:S212	5.28	1	Yes	No	7	6	1	2
R:R:F216	R:R:W303	4.01	1	Yes	Yes	7	8	2	2
R:R:F216	R:R:F307	18.22	1	Yes	Yes	7	7	2	1
R:R:F306	R:R:W303	6.01	1	Yes	Yes	7	8	1	2
R:R:F307	R:R:W303	5.01	1	Yes	Yes	7	8	1	2
R:R:F306	R:R:F307	5.36	1	Yes	Yes	7	7	1	1
R:R:F306	R:R:F325	11.79	1	Yes	No	7	4	1	2
R:R:F306	R:R:N329	13.29	1	Yes	No	7	6	1	1
R:R:N329	R:R:Y333	16.28	1	No	Yes	6	7	1	1
R:R:W330	R:R:Y333	3.86	0	No	Yes	6	7	2	1
R:R:F201	R:R:T118	2.59	0	No	No	4	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7S0G_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.13
Number of Linked Nodes	248
Number of Links	273
Number of Hubs	30
Number of Links mediated by Hubs	123
Number of Communities	9
Number of Nodes involved in Communities	43
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	74
Number Of Links MetaPath	73
Number of Shortest Paths	57905
Length Of Smallest Path	3
Average Path Length	13.7472
Length of Longest Path	33
Minimum Path Strength	1.18
Average Path Strength	6.28534
Maximum Path Strength	21.495
Minimum Path Correlation	0.7
Average Path Correlation	0.92319
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.16667
Average % Of Corr. Nodes	49.3114
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	35.8674
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • peptide hormone receptor binding • protein binding • binding • corticotropin-releasing hormone receptor binding • signaling receptor binding • G protein-coupled receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • D2 dopamine receptor binding • adenylate cyclase inhibitor activity • molecular function inhibitor activity • cyclase inhibitor activity • enzyme inhibitor activity • GTPase activating protein binding • magnesium ion binding • GDP binding • G protein-coupled serotonin receptor binding • G protein activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle • protein localization to postsynapse • intracellular protein localization • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • cell surface receptor signaling pathway • response to cytokine • response to chemokine • cytokine-mediated signaling pathway • cellular response to chemokine • chemokine-mediated signaling pathway • response to peptide • cellular response to cytokine stimulus • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to endogenous stimulus • response to alcohol • response to prostaglandin E • trans-synaptic signaling • modulation of chemical synaptic transmission • negative regulation of synaptic transmission • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • cellular response to forskolin • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • intracellular anatomical structure • cytoplasm • midbody • membrane-bounded organelle • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • intracellular membrane-bounded organelle • nucleolus • intracellular organelle lumen • intracellular organelle • organelle lumen • organelle • membraneless organelle • nuclear lumen • cell cortex • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • synapse • cell junction • glutamatergic synapse • Golgi apparatus • endomembrane system • postsynapse • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • organelle membrane • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta1-adrenergic receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • identical protein binding • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • positive regulation of signaling • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • behavior • circadian behavior • regulation of multicellular organismal process • sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • heart process • regulation of heart contraction • regulation of system process • positive regulation of blood circulation • positive regulation of heart contraction • regulation of blood circulation • positive regulation of multicellular organismal process • heart contraction • positive regulation of cardiac muscle cell apoptotic process • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of striated muscle cell apoptotic process • regulation of apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • cardiac muscle cell apoptotic process • positive regulation of muscle cell apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • programmed cell death • early endosome • endosome • intracellular vesicle • cytoplasmic vesicle • vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • WD40 repeat-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • WD40 repeat-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	5FW
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	5FW
Name	ISOPRENALINE
Synonyms
Identifier
Formula	C11 H17 N O3
Molecular Weight	211.258
SMILES
PubChem	443372
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07700
Sequence	>7S0G_nogp_Chain_R W E A G M S L L M A L V V L L I V A G N V L V I A A I G S T Q R L Q T L T N L F I T S L A C A D L V V G L L V V P F G A T L V V R G T W L W G S F L C E L W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S P F R Y Q S L M T R A R A K V I I C T V W A I S A L V S F L P I M M H W W R D E D P Q A L K C Y Q D P G C C D F V T N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N R D L V P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F R K A F K R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2VT4	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.7	2008-06-24	doi.org/10.1038/nature07101
	2Y00	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.5	2011-01-12	doi.org/10.1038/nature09746
	2Y02	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carmoterol	-	-	2.6	2011-01-12	doi.org/10.1038/nature09746
	2Y03	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.85	2011-01-12	doi.org/10.1038/nature09746
	2Y04	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	3.05	2011-01-12	doi.org/10.1038/nature09746
	2Y01	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.6	2011-03-30	doi.org/10.1038/nature09746
	2YCW	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carazolol	-	-	3	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCX	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.25	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCZ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Iodocyanopindolol	-	-	3.65	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCY	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.15	2011-06-08	doi.org/10.1073/pnas.1100185108
	4AMI	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Bucindolol	-	-	3.2	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	4AMJ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carvedilol	-	-	2.3	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	4GPO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	-	-	-	3.5	2013-02-27	doi.org/10.1038/nsmb.2504
	3ZPQ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	PubChem 594590	Na	-	2.8	2013-04-03	doi.org/10.1021/jm400140q
	3ZPR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	PubChem 598754	Na	-	2.7	2013-04-03	doi.org/10.1021/jm400140q
	4BVN	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	Na	-	2.1	2014-04-02	doi.org/10.1371/journal.pone.0092727
	5A8E	A	Amine	Adrenergic	β₁	Meleagris gallopavo	7-Methylcyanopindolol	Na	-	2.4	2015-09-30	doi.org/10.1124/mol.115.101030
	5F8U	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.35	2015-12-23	doi.org/10.1038/nsmb.3130
	6H7J	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	6H7L	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.7	2018-10-17	doi.org/10.1126/science.aau5595
	6H7M	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	2.76	2018-10-17	doi.org/10.1126/science.aau5595
	6H7N	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Xamoterol	-	-	2.5	2018-10-17	doi.org/10.1101/436212
	6H7O	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	6IBL	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	-	2.7	2019-01-09	doi.org/10.1038/s41586-020-2419-1
	6TKO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	Arrestin2	3.3	2020-06-17	doi.org/10.1038/s41586-020-2419-1
	7JJO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gs/β1/γ2	2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	7JJO (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	7BTS	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	-	-	3.13	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU6	A	Amine	Adrenergic	β₁	Homo sapiens	Norepinephrine	-	-	2.7	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU7	A	Amine	Adrenergic	β₁	Homo sapiens	BI167107	-	-	2.6	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BVQ	A	Amine	Adrenergic	β₁	Homo sapiens	Carazolol	-	-	2.5	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7S0F	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gi1/β1/γ2	2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0F (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	chim(Gi1-CtGs)/β1/γ2	3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	8DCR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	Gs/β1/γ2	2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCR (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-		2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	Gs/β1/γ2	2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-		2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8S2T	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-05-21	To be published
	8S2T (No Gprot)	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-		3.3	2025-05-21	To be published
	9L84	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	Atazanavir	Gs/β1/γ2	3.22	2025-12-31	To be published
	9L84 (No Gprot)	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	Atazanavir		3.22	2025-12-31	To be published

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7S0G_nogp.zip

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