psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:Q55	R:R:Q56	6.4	No	No	5	2	2
2	R:R:Q55	R:R:W57	9.86	No	No	5	2	1
3	R:R:Q56	R:R:W57	28.48	No	No	5	2	1
4	R:R:M65	R:R:V119	4.56	No	No	1	6	5
5	R:R:M65	R:R:W364	10.47	No	Yes	1	6	7
6	R:R:L67	R:R:L71	6.92	No	No	0	4	4
7	R:R:I68	R:R:I72	5.89	No	Yes	6	7	8
8	R:R:V112	R:R:V69	6.41	Yes	No	0	7	6
9	R:R:I72	R:R:S370	4.64	Yes	No	0	8	9
10	R:R:L105	R:R:V73	4.47	Yes	No	7	7	5
11	R:R:L109	R:R:V73	5.96	No	No	7	5	5
12	R:R:G75	R:R:P374	4.06	No	No	0	8	9
13	R:R:A101	R:R:N76	4.69	No	No	0	9	9
14	R:R:D104	R:R:N76	6.73	Yes	No	0	9	9
15	R:R:N76	R:R:P374	9.77	No	No	0	9	9
16	R:R:C378	R:R:V79	6.83	No	No	0	8	9
17	R:R:I80	R:R:M98	5.83	No	No	0	7	6
18	R:R:L390	R:R:V81	5.96	No	No	0	5	4
19	R:R:I83	R:R:L89	5.71	Yes	Yes	4	7	8
20	R:R:I83	R:R:N94	4.25	Yes	Yes	4	7	9
21	R:R:I83	R:R:M98	4.37	Yes	No	0	7	6
22	R:R:F383	R:R:I83	5.02	Yes	Yes	4	8	7
23	R:R:L89	R:R:T86	5.9	Yes	No	0	8	6
24	R:R:A386	R:R:T86	5.03	No	No	0	7	6
25	R:R:D382	R:R:R88	14.29	No	No	0	7	6
26	R:R:L89	R:R:N94	4.12	Yes	Yes	4	8	9
27	R:R:F383	R:R:L89	9.74	Yes	Yes	4	8	8
28	R:R:N94	R:R:T91	4.39	Yes	No	0	9	7
29	R:R:L170	R:R:L92	6.92	Yes	No	0	7	6
30	R:R:D155	R:R:T93	8.67	Yes	No	0	9	8
31	R:R:I97	R:R:N94	5.66	No	Yes	0	8	9
32	R:R:F383	R:R:N94	7.25	Yes	Yes	4	8	9
33	R:R:L95	R:R:R176	8.5	No	No	0	5	4
34	R:R:L95	R:R:V179	8.94	No	Yes	0	5	7
35	R:R:F96	R:R:V151	9.18	Yes	No	2	8	7
36	R:R:D155	R:R:F96	10.75	Yes	Yes	2	9	8
37	R:R:F96	R:R:L178	4.87	Yes	No	2	8	6
38	R:R:F96	R:R:V179	3.93	Yes	Yes	0	8	7
39	R:R:S99	R:R:T148	7.99	No	No	0	9	7
40	R:R:S99	R:R:W183	6.18	No	Yes	0	9	9
41	R:R:D104	R:R:L100	8.14	Yes	Yes	1	9	9
42	R:R:L100	R:R:T148	5.9	Yes	No	0	9	7
43	R:R:L100	R:R:L149	5.54	Yes	Yes	1	9	8
44	R:R:L100	R:R:N373	8.24	Yes	Yes	1	9	9
45	R:R:L100	R:R:Y377	4.69	Yes	Yes	1	9	9
46	R:R:D104	R:R:S145	7.36	Yes	No	0	9	9
47	R:R:D104	R:R:S370	11.78	Yes	No	0	9	9
48	R:R:D104	R:R:N373	8.08	Yes	Yes	1	9	9
49	R:R:L105	R:R:L109	8.3	Yes	No	7	7	5
50	R:R:L110	R:R:V106	4.47	No	No	0	6	7
51	R:R:C141	R:R:V106	6.83	No	No	0	7	7
52	R:R:C141	R:R:V107	5.12	No	No	0	7	7
53	R:R:V107	R:R:Y367	3.79	No	Yes	0	7	8
54	R:R:S370	R:R:V107	9.7	No	No	0	9	7
55	R:R:V111	R:R:W134	4.9	No	Yes	1	7	5
56	R:R:D138	R:R:V111	10.22	Yes	No	1	7	7
57	R:R:V111	R:R:Y367	6.31	No	Yes	1	7	8
58	R:R:V112	R:R:W364	7.36	Yes	Yes	1	7	7
59	R:R:V112	R:R:Y367	3.79	Yes	Yes	1	7	8
60	R:R:F114	R:R:W124	5.01	No	Yes	1	5	7
61	R:R:F114	R:R:Y126	8.25	No	Yes	1	5	5
62	R:R:F114	R:R:W134	7.02	No	Yes	1	5	5
63	R:R:I118	R:R:T117	4.56	No	No	0	6	5
64	R:R:T117	R:R:W121	8.49	No	Yes	0	5	4
65	R:R:T117	R:R:Y126	3.75	No	Yes	0	5	5
66	R:R:V119	R:R:W364	4.9	No	Yes	1	5	7
67	R:R:R123	R:R:W121	12	No	Yes	8	3	4
68	R:R:E125	R:R:W121	6.54	No	Yes	8	3	4
69	R:R:E125	R:R:R123	11.63	No	No	8	3	3
70	R:R:W124	R:R:Y126	23.15	Yes	Yes	1	7	5
71	R:R:C131	R:R:W124	9.14	No	Yes	1	9	7
72	R:R:W124	R:R:W134	9.37	Yes	Yes	1	7	5
73	R:R:C216	R:R:W124	10.45	No	Yes	1	9	7
74	R:R:F130	R:R:Y126	4.13	No	Yes	0	4	5
75	R:R:F129	R:R:F130	8.57	No	No	0	1	4
76	R:R:F129	R:R:L133	6.09	No	No	0	1	4
77	R:R:C131	R:R:C216	7.28	No	No	1	9	9
78	R:R:E132	R:R:Y210	11.22	No	Yes	0	6	4
79	L:L:?1	R:R:W134	5.56	Yes	Yes	1	0	5
80	R:R:I194	R:R:T135	6.08	Yes	No	0	6	5
81	R:R:F191	R:R:S136	7.93	Yes	No	1	4	6
82	R:R:I194	R:R:S136	7.74	Yes	No	1	6	6
83	R:R:L195	R:R:S136	10.51	No	No	1	4	6
84	R:R:D138	R:R:V142	4.38	Yes	No	1	7	6
85	R:R:D138	R:R:Y367	10.34	Yes	Yes	1	7	8
86	L:L:?1	R:R:D138	19.87	Yes	Yes	1	0	7
87	R:R:V139	R:R:Y224	3.79	No	Yes	0	7	7
88	L:L:?1	R:R:V139	14.54	Yes	No	0	0	7
89	R:R:L140	R:R:W183	5.69	Yes	Yes	0	6	9
90	R:R:L140	R:R:S190	6.01	Yes	No	1	6	7
91	R:R:F191	R:R:L140	9.74	Yes	Yes	1	4	6
92	R:R:V142	R:R:W337	12.26	No	Yes	1	6	8
93	L:L:?1	R:R:V142	9.69	Yes	No	1	0	6
94	R:R:S186	R:R:T143	6.4	No	No	0	8	7
95	R:R:T143	R:R:V189	4.76	No	No	0	7	6
96	R:R:S232	R:R:T143	9.59	No	No	0	7	7
97	R:R:A144	R:R:W183	7.78	No	Yes	0	8	9
98	R:R:F333	R:R:V146	6.55	Yes	No	0	9	8
99	R:R:C150	R:R:W147	7.84	No	Yes	0	7	6
100	R:R:V182	R:R:W147	3.68	No	Yes	0	6	6
101	R:R:I185	R:R:W147	7.05	No	Yes	0	5	6
102	R:R:V235	R:R:W147	3.68	No	Yes	0	6	6
103	R:R:P236	R:R:W147	12.16	No	Yes	0	9	6
104	R:R:T148	R:R:V182	4.76	No	No	0	7	6
105	R:R:F333	R:R:L149	4.87	Yes	Yes	1	9	8
106	R:R:L149	R:R:N373	8.24	Yes	Yes	1	8	9
107	R:R:L149	R:R:Y377	8.21	Yes	Yes	1	8	9
108	R:R:C150	R:R:I239	6.55	No	No	0	7	6
109	R:R:L178	R:R:V151	7.45	No	No	2	6	7
110	R:R:I152	R:R:R156	6.26	No	No	0	9	9
111	R:R:I152	R:R:Y377	4.84	No	Yes	0	9	9
112	R:R:A153	R:R:V243	5.09	No	Yes	3	9	7
113	R:R:A153	R:R:Y244	6.67	No	Yes	3	9	9
114	R:R:I239	R:R:L154	4.28	No	No	0	6	6
115	R:R:D155	R:R:Y166	10.34	Yes	Yes	2	9	8
116	R:R:D155	R:R:L170	4.07	Yes	Yes	2	9	7
117	R:R:T161	R:R:Y157	23.72	No	Yes	0	6	8
118	R:R:F242	R:R:Y157	4.13	No	Yes	3	5	8
119	R:R:V243	R:R:Y157	10.09	Yes	Yes	3	7	8
120	R:R:R246	R:R:Y157	10.29	No	Yes	3	5	8
121	R:R:L158	R:R:Y166	4.69	No	Yes	0	5	8
122	R:R:A159	R:R:Y166	8.01	No	Yes	0	8	8
123	R:R:I160	R:R:V247	4.61	No	No	0	9	9
124	R:R:R165	R:R:S162	5.27	No	No	0	6	6
125	R:R:Q167	R:R:Y166	4.51	No	Yes	0	6	8
126	R:R:L170	R:R:Y166	7.03	Yes	Yes	2	7	8
127	R:R:R174	R:R:T171	5.17	No	No	0	7	8
128	R:R:V189	R:R:V231	6.41	No	No	0	6	4
129	R:R:F191	R:R:S190	6.61	Yes	No	1	4	7
130	R:R:F191	R:R:L195	6.09	Yes	No	1	4	4
131	R:R:L192	R:R:P193	4.93	No	No	1	7	7
132	R:R:L192	R:R:W198	10.25	No	No	1	7	5
133	R:R:P193	R:R:W198	4.05	No	No	1	7	5
134	R:R:P193	R:R:Y224	4.17	No	Yes	1	7	7
135	R:R:I194	R:R:W199	8.22	Yes	Yes	1	6	6
136	R:R:I194	R:R:Y224	4.84	Yes	Yes	1	6	7
137	R:R:M196	R:R:W198	10.47	No	No	0	4	5
138	R:R:H197	R:R:Y210	9.8	No	Yes	0	3	4
139	R:R:W199	R:R:Y210	4.82	Yes	Yes	0	6	4
140	R:R:F218	R:R:W199	9.02	Yes	Yes	1	6	6
141	R:R:T220	R:R:W199	8.49	No	Yes	1	5	6
142	R:R:W199	R:R:Y224	11.58	Yes	Yes	1	6	7
143	R:R:E202	R:R:R222	13.96	No	No	0	2	3
144	R:R:E205	R:R:R208	12.79	No	No	0	2	1
145	R:R:A206	R:R:R351	4.15	No	No	0	3	4
146	R:R:D212	R:R:R208	5.96	Yes	No	0	3	1
147	R:R:C209	R:R:C215	7.28	No	No	9	5	4
148	R:R:C209	R:R:V219	5.12	No	Yes	0	5	4
149	R:R:D212	R:R:P213	4.83	Yes	No	0	3	3
150	R:R:C215	R:R:D212	6.22	No	Yes	0	4	3
151	R:R:F218	R:R:T220	5.19	Yes	No	1	6	5
152	R:R:F218	R:R:N344	4.83	Yes	Yes	1	6	6
153	R:R:F218	R:R:F359	6.43	Yes	Yes	1	6	5
154	L:L:?1	R:R:F218	19.81	Yes	Yes	1	0	6
155	R:R:N221	R:R:Y224	4.65	No	Yes	0	5	7
156	R:R:F349	R:R:R222	9.62	Yes	No	0	5	3
157	R:R:S228	R:R:Y224	15.26	No	Yes	0	6	7
158	R:R:F349	R:R:I226	5.02	Yes	No	0	5	5
159	L:L:?1	R:R:S228	7.33	Yes	No	0	0	6
160	R:R:F341	R:R:S229	7.93	Yes	No	1	7	7
161	R:R:N344	R:R:S229	5.96	Yes	No	1	6	7
162	L:L:?1	R:R:S232	4.88	Yes	No	0	0	7
163	R:R:F233	R:R:Y234	9.28	Yes	Yes	0	8	5
164	R:R:F233	R:R:L237	12.18	Yes	No	1	8	6
165	R:R:F233	R:R:F333	6.43	Yes	Yes	1	8	9
166	R:R:F233	R:R:W337	4.01	Yes	Yes	1	8	8
167	R:R:F233	R:R:L338	4.87	Yes	Yes	0	8	6
168	R:R:F233	R:R:F341	27.86	Yes	Yes	1	8	7
169	R:R:L342	R:R:Y234	4.69	No	Yes	0	5	5
170	R:R:F333	R:R:L237	4.87	Yes	No	1	9	6
171	R:R:L237	R:R:T334	4.42	No	No	0	6	6
172	R:R:M240	R:R:M330	4.33	No	Yes	0	8	8
173	R:R:F333	R:R:M240	7.46	Yes	No	0	9	8
174	R:R:F242	R:R:R246	14.97	No	No	3	5	5
175	R:R:V243	R:R:Y244	3.79	Yes	Yes	3	7	9
176	R:R:L326	R:R:Y244	8.21	No	Yes	0	8	9
177	R:R:I329	R:R:Y244	6.04	No	Yes	0	8	9
178	R:R:M330	R:R:Y244	4.79	Yes	Yes	0	8	9
179	R:R:L245	R:R:R249	15.79	No	No	0	2	4
180	R:R:F248	R:R:Q252	15.23	Yes	No	0	6	6
181	R:R:F248	R:R:L323	4.87	Yes	No	0	6	8
182	R:R:E250	R:R:K253	10.8	No	No	0	6	4
183	R:R:E319	R:R:Q252	3.82	No	No	0	8	6
184	R:R:D259	R:R:V255	4.38	No	No	0	4	6
185	R:R:E262	R:R:I258	6.83	No	No	0	3	5
186	R:R:R263	R:R:R264	5.33	No	No	0	2	4
187	R:R:I328	R:R:I376	4.42	No	No	0	6	8
188	R:R:I329	R:R:Y377	9.67	No	Yes	0	8	9
189	R:R:M372	R:R:V332	6.09	No	No	0	6	6
190	R:R:I376	R:R:V332	4.61	No	No	0	8	6
191	R:R:F333	R:R:W337	4.01	Yes	Yes	1	9	8
192	R:R:L338	R:R:T334	4.42	Yes	No	0	6	6
193	R:R:C336	R:R:N369	7.87	No	No	0	8	9
194	R:R:F340	R:R:W337	7.02	Yes	Yes	1	7	8
195	R:R:F341	R:R:W337	11.02	Yes	Yes	1	7	8
196	R:R:G366	R:R:W337	11.26	No	Yes	0	7	8
197	R:R:N369	R:R:W337	6.78	No	Yes	0	9	8
198	L:L:?1	R:R:W337	3.71	Yes	Yes	1	0	8
199	R:R:L338	R:R:L342	8.3	Yes	No	0	6	5
200	R:R:F362	R:R:P339	10.11	No	No	0	5	9
201	R:R:F340	R:R:F341	9.65	Yes	Yes	1	7	7
202	R:R:F340	R:R:N344	14.5	Yes	Yes	1	7	6
203	R:R:F340	R:R:F359	10.72	Yes	Yes	1	7	5
204	R:R:F340	R:R:N363	14.5	Yes	No	1	7	6
205	L:L:?1	R:R:F340	11.89	Yes	Yes	1	0	7
206	R:R:F341	R:R:N344	4.83	Yes	Yes	1	7	6
207	L:L:?1	R:R:F341	14.86	Yes	Yes	1	0	7
208	R:R:F359	R:R:N344	6.04	Yes	Yes	1	5	6
209	L:L:?1	R:R:N344	4.47	Yes	Yes	1	0	6
210	R:R:L353	R:R:V346	5.96	No	No	0	3	5
211	R:R:V346	R:R:V354	6.41	No	No	0	5	5
212	R:R:F359	R:R:K347	9.93	Yes	No	0	5	4
213	R:R:A348	R:R:F349	4.16	No	Yes	0	5	5
214	R:R:L358	R:R:V354	4.47	No	No	0	5	5
215	R:R:L358	R:R:P355	6.57	No	No	0	5	5
216	R:R:D356	R:R:R357	5.96	No	No	0	2	1
217	R:R:F362	R:R:L358	14.61	No	No	0	5	5
218	R:R:N363	R:R:Y367	15.12	No	Yes	1	6	8
219	L:L:?1	R:R:N363	16.75	Yes	No	1	0	6
220	R:R:W364	R:R:Y367	14.47	Yes	Yes	1	7	8
221	L:L:?1	R:R:Y367	5.72	Yes	Yes	1	0	8
222	R:R:N369	R:R:N373	13.62	No	Yes	0	9	9
223	R:R:I375	R:R:M372	4.37	No	No	0	6	6
224	R:R:N373	R:R:Y377	8.14	Yes	Yes	1	9	9
225	R:R:I375	R:R:R379	3.76	No	No	0	6	5
226	R:R:I376	R:R:Y377	13.3	No	Yes	0	8	9
227	R:R:C378	R:R:F383	15.36	No	Yes	0	8	8
228	R:R:F387	R:R:R379	4.28	Yes	No	0	7	5
229	R:R:F383	R:R:S380	6.61	Yes	No	0	8	9
230	R:R:P381	R:R:R384	11.53	No	No	0	5	9
231	R:R:F383	R:R:F387	7.5	Yes	Yes	0	8	7
232	R:R:F387	R:R:L78	3.65	Yes	No	0	7	7
233	R:R:F248	R:R:L326	3.65	Yes	No	0	6	8
234	R:R:L92	R:R:R172	3.64	No	No	0	6	3
235	R:R:P213	R:R:S128	3.56	No	No	0	3	4
236	R:R:P381	R:R:S380	3.56	No	No	0	5	9
237	R:R:G108	R:R:I72	3.53	No	Yes	0	7	8
238	R:R:P113	R:R:V112	3.53	No	Yes	0	9	7
239	R:R:P87	R:R:T86	3.5	No	No	0	7	6
240	R:R:E352	R:R:R351	3.49	No	No	0	5	4
241	R:R:A206	R:R:S203	3.42	No	No	0	3	2
242	R:R:H197	R:R:R200	3.39	No	No	0	3	5
243	R:R:A201	R:R:V219	3.39	No	Yes	0	4	4
244	R:R:A206	R:R:V219	3.39	No	Yes	0	3	4
245	R:R:A343	R:R:V354	3.39	No	No	0	4	5
246	R:R:L338	R:R:P339	3.28	Yes	No	0	6	9
247	R:R:S85	R:R:V81	3.23	No	No	0	5	4
248	R:R:S99	R:R:V179	3.23	No	Yes	0	9	7
249	R:R:A116	R:R:M65	3.22	No	No	0	6	6
250	R:R:C336	R:R:L365	3.17	No	No	0	8	7
251	R:R:A175	R:R:L170	3.15	No	Yes	0	7	7
252	R:R:I226	R:R:V345	3.07	No	No	0	5	5
253	R:R:I185	R:R:T181	3.04	No	No	0	5	3
254	R:R:L105	R:R:V77	2.98	Yes	No	0	7	3
255	R:R:L110	R:R:V137	2.98	No	No	0	6	5
256	R:R:L133	R:R:V137	2.98	No	No	0	4	5
257	R:R:D204	R:R:S203	2.94	No	No	0	2	2
258	R:R:D382	R:R:S380	2.94	No	No	0	7	9
259	R:R:I80	R:R:L105	2.85	No	Yes	0	7	7
260	R:R:G115	R:R:W364	2.81	No	Yes	0	6	7
261	R:R:A82	R:R:F387	2.77	No	Yes	0	8	7
262	R:R:L158	R:R:L169	2.77	No	No	0	5	5
263	R:R:L188	R:R:L192	2.77	No	No	0	4	7
264	R:R:A201	R:R:R207	2.77	No	No	0	4	3
265	R:R:A322	R:R:F248	2.77	No	Yes	0	8	6
266	R:R:E250	R:R:I160	2.73	No	No	0	6	9
267	R:R:A103	R:R:W183	2.59	No	Yes	0	8	9
268	R:R:V219	R:R:Y210	2.52	Yes	Yes	0	4	4
269	R:R:V230	R:R:Y234	2.52	No	Yes	0	4	5
270	R:R:V345	R:R:Y234	2.52	No	Yes	0	5	5
271	R:R:S102	R:R:W183	2.47	No	Yes	0	6	9
272	R:R:V120	R:R:W121	2.45	No	Yes	0	5	4
273	R:R:V360	R:R:W364	2.45	No	Yes	0	5	7
274	R:R:L169	R:R:R165	2.43	No	No	0	5	6
275	R:R:Q252	R:R:R249	2.34	No	No	0	6	4
276	R:R:A59	R:R:G60	1.95	No	No	0	4	3
277	R:R:A74	R:R:G75	1.95	No	No	0	3	8
278	R:R:G62	R:R:V120	1.84	No	No	0	5	5
279	R:R:A225	R:R:A348	1.79	No	No	0	6	5
280	R:R:A251	R:R:A322	1.79	No	No	0	9	8
281	R:R:P163	R:R:S162	1.78	No	No	0	8	6
282	R:R:G331	R:R:M330	1.75	No	Yes	0	6	8
283	R:R:C261	R:R:S260	1.72	No	No	0	4	4
284	R:R:C180	R:R:V179	1.71	No	Yes	0	3	7
285	R:R:A173	R:R:T171	1.68	No	No	0	5	8
286	R:R:A368	R:R:I68	1.62	No	No	0	4	7
287	R:R:A371	R:R:I68	1.62	No	No	6	6	7
288	R:R:A371	R:R:I72	1.62	No	Yes	6	6	8
289	R:R:A84	R:R:M98	1.61	No	No	0	3	6
290	R:R:A241	R:R:M330	1.61	No	Yes	0	4	8
291	R:R:D356	R:R:P355	1.61	No	No	0	2	5
292	R:R:V77	R:R:V81	1.6	No	No	0	3	4
293	R:R:V243	R:R:V247	1.6	Yes	No	0	7	9
294	R:R:T58	R:R:V120	1.59	No	No	0	3	5
295	R:R:A371	R:R:L71	1.58	No	No	0	6	4
296	R:R:A187	R:R:L140	1.58	No	Yes	0	4	6
297	R:R:C209	R:R:D217	1.56	No	No	9	5	4
298	R:R:C215	R:R:D217	1.56	No	No	9	4	4
299	R:R:A223	R:R:N221	1.56	No	No	0	3	5
300	R:R:M61	R:R:V119	1.52	No	No	0	4	5
301	R:R:I329	R:R:T325	1.52	No	No	0	8	9
302	R:R:F130	R:R:G127	1.51	No	No	0	4	5
303	R:R:G122	R:R:R123	1.5	No	No	0	4	3
304	R:R:G177	R:R:R176	1.5	No	No	0	2	4
305	R:R:L70	R:R:V69	1.49	No	No	0	4	6
306	R:R:I328	R:R:K324	1.45	No	No	0	6	7
307	R:R:Q167	R:R:S168	1.44	No	No	0	6	5
308	R:R:L64	R:R:M61	1.41	No	No	0	4	4
309	R:R:L391	R:R:L78	1.38	No	No	0	6	7
310	R:R:D212	R:R:K214	1.38	Yes	No	0	3	1
311	R:R:I83	R:R:Q90	1.37	Yes	No	0	7	8
312	R:R:L391	R:R:Q388	1.33	No	No	0	6	5
313	R:R:L169	R:R:R174	1.21	No	No	0	5	7
314	R:R:L170	R:R:R174	1.21	Yes	No	0	7	7
315	R:R:F349	R:R:H350	1.13	Yes	No	0	5	4
316	R:R:F265	R:R:R264	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:I72	3.92	4	6	8
2	R:R:I83	4.144	5	4	7
3	R:R:L89	6.3675	4	4	8
4	R:R:N94	5.134	5	4	9
5	R:R:F96	7.1825	4	2	8
6	R:R:L100	6.502	5	1	9
7	R:R:D104	8.418	5	1	9
8	R:R:L105	4.65	4	7	7
9	R:R:V112	5.2725	4	1	7
10	R:R:W121	7.37	4	8	4
11	R:R:W124	11.424	5	1	7
12	R:R:Y126	9.82	4	1	5
13	R:R:W134	6.7125	4	1	5
14	R:R:D138	11.2025	4	1	7
15	R:R:L140	5.755	4	1	6
16	R:R:W147	6.882	5	0	6
17	R:R:L149	6.715	4	1	8
18	R:R:D155	8.4575	4	2	9
19	R:R:Y157	12.0575	4	3	8
20	R:R:Y166	6.916	5	2	8
21	R:R:L170	4.476	5	2	7
22	R:R:V179	4.4525	4	0	7
23	R:R:W183	4.942	5	0	9
24	R:R:F191	7.5925	4	1	4
25	R:R:I194	6.72	4	1	6
26	R:R:W199	8.426	5	1	6
27	R:R:Y210	7.09	4	0	4
28	R:R:D212	4.5975	4	0	3
29	R:R:F218	9.056	5	1	6
30	R:R:V219	3.605	4	0	4
31	R:R:Y224	7.38167	6	1	7
32	R:R:F233	10.7717	6	1	8
33	R:R:Y234	4.7525	4	0	5
34	R:R:V243	5.1425	4	3	7
35	R:R:Y244	5.9	5	3	9
36	R:R:F248	6.63	4	0	6
37	R:R:M330	3.12	4	0	8
38	R:R:F333	5.69833	6	1	9
39	R:R:W337	7.50875	8	1	8
40	R:R:L338	5.2175	4	0	6
41	R:R:F340	11.38	6	1	7
42	R:R:F341	12.6917	6	1	7
43	R:R:N344	6.77167	6	1	6
44	R:R:F349	4.9825	4	0	5
45	R:R:F359	8.28	4	1	5
46	R:R:W364	7.07667	6	1	7
47	R:R:Y367	8.50571	7	1	8
48	R:R:N373	9.264	5	1	9
49	R:R:Y377	8.14167	6	1	9
50	R:R:F383	8.58	6	4	8
51	R:R:F387	4.55	4	0	7
52	L:L:?1	10.6985	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I72	R:R:S370	15.8096	4.64	Yes	No	0	8	9
2	R:R:S370	R:R:V107	26.0761	9.7	No	No	0	9	7
3	R:R:V107	R:R:Y367	24.778	3.79	No	Yes	0	7	8
4	R:R:W364	R:R:Y367	17.4174	14.47	Yes	Yes	1	7	8
5	R:R:I80	R:R:L105	14.4386	2.85	No	Yes	0	7	7
6	R:R:I80	R:R:M98	16.4655	5.83	No	No	0	7	6
7	R:R:I83	R:R:M98	20.4919	4.37	Yes	No	0	7	6
8	R:R:F383	R:R:I83	24.0993	5.02	Yes	Yes	4	8	7
9	R:R:F383	R:R:F387	53.2453	7.5	Yes	Yes	0	8	7
10	R:R:F387	R:R:R379	62.3776	4.28	Yes	No	0	7	5
11	R:R:I375	R:R:R379	64.1767	3.76	No	No	0	6	5
12	R:R:I375	R:R:M372	65.9668	4.37	No	No	0	6	6
13	R:R:M372	R:R:V332	67.7477	6.09	No	No	0	6	6
14	R:R:I376	R:R:V332	69.5195	4.61	No	No	0	8	6
15	R:R:I376	R:R:Y377	74.7802	13.3	No	Yes	0	8	9
16	R:R:L100	R:R:Y377	24.9693	4.69	Yes	Yes	1	9	9
17	R:R:D104	R:R:L100	19.8041	8.14	Yes	Yes	1	9	9
18	R:R:D104	R:R:S370	29.0276	11.78	Yes	No	0	9	9
19	R:R:N373	R:R:Y377	33.7554	8.14	Yes	Yes	1	9	9
20	R:R:D104	R:R:N373	16.552	8.08	Yes	Yes	1	9	9
21	R:R:L149	R:R:Y377	30.1389	8.21	Yes	Yes	1	8	9
22	R:R:F333	R:R:L149	56.215	4.87	Yes	Yes	1	9	8
23	R:R:F333	R:R:W337	53.2863	4.01	Yes	Yes	1	9	8
24	L:L:?1	R:R:W337	100	3.71	Yes	Yes	1	0	8
25	L:L:?1	R:R:Y367	29.9021	5.72	Yes	Yes	1	0	8
26	R:R:N369	R:R:N373	44.0173	13.62	No	Yes	0	9	9
27	R:R:N369	R:R:W337	44.4546	6.78	No	Yes	0	9	8
28	R:R:D104	R:R:N76	11.8379	6.73	Yes	No	0	9	9
29	R:R:F383	R:R:S380	10.3575	6.61	Yes	No	0	8	9
30	R:R:D155	R:R:L170	16.174	4.07	Yes	Yes	2	9	7
31	R:R:D155	R:R:F96	32.0701	10.75	Yes	Yes	2	9	8
32	R:R:F96	R:R:V179	36.1193	3.93	Yes	Yes	0	8	7
33	R:R:S99	R:R:V179	42.6782	3.23	No	Yes	0	9	7
34	R:R:S99	R:R:T148	46.6545	7.99	No	No	0	9	7
35	R:R:L100	R:R:T148	58.5425	5.9	Yes	No	0	9	7
36	R:R:S99	R:R:W183	15.6593	6.18	No	Yes	0	9	9
37	R:R:F114	R:R:W134	28.4036	7.02	No	Yes	1	5	5
38	L:L:?1	R:R:W134	59.335	5.56	Yes	Yes	1	0	5
39	R:R:W124	R:R:W134	32.4026	9.37	Yes	Yes	1	7	5
40	R:R:F114	R:R:Y126	26.4769	8.25	No	Yes	1	5	5
41	R:R:W124	R:R:Y126	26.6226	23.15	Yes	Yes	1	7	5
42	R:R:T117	R:R:Y126	36.1694	3.75	No	Yes	0	5	5
43	R:R:T117	R:R:W121	28.1621	8.49	No	Yes	0	5	4
44	R:R:F130	R:R:Y126	13.5778	4.13	No	Yes	0	4	5
45	R:R:W199	R:R:Y210	36.8435	4.82	Yes	Yes	0	6	4
46	R:R:F218	R:R:W199	39.5992	9.02	Yes	Yes	1	6	6
47	L:L:?1	R:R:F218	38.1508	19.81	Yes	Yes	1	0	6
48	R:R:I194	R:R:W199	12.8809	8.22	Yes	Yes	1	6	6
49	R:R:F191	R:R:S136	16.0419	7.93	Yes	No	1	4	6
50	R:R:I194	R:R:S136	20.246	7.74	Yes	No	1	6	6
51	R:R:I194	R:R:Y224	14.5343	4.84	Yes	Yes	1	6	7
52	R:R:V139	R:R:Y224	16.921	3.79	No	Yes	0	7	7
53	L:L:?1	R:R:V139	18.2327	14.54	Yes	No	0	0	7
54	R:R:S228	R:R:Y224	16.9802	15.26	No	Yes	0	6	7
55	L:L:?1	R:R:S228	18.2783	7.33	Yes	No	0	0	6
56	R:R:F191	R:R:L140	13.2726	9.74	Yes	Yes	1	4	6
57	R:R:V182	R:R:W147	14.8987	3.68	No	Yes	0	6	6
58	R:R:T148	R:R:V182	16.7206	4.76	No	No	0	7	6
59	R:R:M330	R:R:Y244	15.9235	4.79	Yes	Yes	0	8	9
60	R:R:M240	R:R:M330	17.3582	4.33	No	Yes	0	8	8
61	R:R:F333	R:R:M240	18.5698	7.46	Yes	No	0	9	8
62	R:R:V243	R:R:Y244	12.6122	3.79	Yes	Yes	3	7	9
63	R:R:D155	R:R:Y166	13.2362	10.34	Yes	Yes	2	9	8
64	R:R:L170	R:R:R174	10.476	1.21	Yes	No	0	7	7
65	R:R:P193	R:R:Y224	15.1173	4.17	No	Yes	1	7	7
66	R:R:F349	R:R:I226	13.933	5.02	Yes	No	0	5	5
67	R:R:I226	R:R:V345	16.2241	3.07	No	No	0	5	5
68	R:R:V345	R:R:Y234	18.4423	2.52	No	Yes	0	5	5
69	R:R:F233	R:R:Y234	24.573	9.28	Yes	Yes	0	8	5
70	R:R:F233	R:R:W337	19.0025	4.01	Yes	Yes	1	8	8
71	R:R:F233	R:R:F341	22.1954	27.86	Yes	Yes	1	8	7
72	L:L:?1	R:R:F341	16.8618	14.86	Yes	Yes	1	0	7
73	R:R:C215	R:R:D212	10.9542	6.22	No	Yes	0	4	3
74	R:R:C209	R:R:C215	12.7169	7.28	No	No	9	5	4
75	R:R:C209	R:R:V219	16.3106	5.12	No	Yes	0	5	4
76	R:R:V219	R:R:Y210	30.1936	2.52	Yes	Yes	0	4	4
77	R:R:F233	R:R:L338	28.0938	4.87	Yes	Yes	0	8	6
78	R:R:L326	R:R:Y244	12.7442	8.21	No	Yes	0	8	9
79	R:R:I329	R:R:Y377	18.4742	9.67	No	Yes	0	8	9
80	R:R:F248	R:R:L326	11.3642	3.65	Yes	No	0	6	8
81	R:R:F362	R:R:P339	20.6969	10.11	No	No	0	5	9
82	R:R:L338	R:R:P339	22.9515	3.28	Yes	No	0	6	9
83	R:R:F362	R:R:L358	18.4332	14.61	No	No	0	5	5
84	R:R:V120	R:R:W121	12.0383	2.45	No	Yes	0	5	4
85	R:R:L100	R:R:L149	23.6484	5.54	Yes	Yes	1	9	8
86	R:R:L140	R:R:W183	13.5277	5.69	Yes	Yes	0	6	9
87	R:R:I329	R:R:Y244	14.7392	6.04	No	Yes	0	8	9
88	R:R:F233	R:R:F333	18.0733	6.43	Yes	Yes	1	8	9
89	R:R:L100	R:R:N373	14.2655	8.24	Yes	Yes	1	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V107	R:R:Y367	3.79	0	No	Yes	7	8	2	1
R:R:V111	R:R:W134	4.9	1	No	Yes	7	5	2	1
R:R:D138	R:R:V111	10.22	1	Yes	No	7	7	1	2
R:R:V111	R:R:Y367	6.31	1	No	Yes	7	8	2	1
R:R:V112	R:R:W364	7.36	1	Yes	Yes	7	7	2	2
R:R:V112	R:R:Y367	3.79	1	Yes	Yes	7	8	2	1
R:R:F114	R:R:W124	5.01	1	No	Yes	5	7	2	2
R:R:F114	R:R:W134	7.02	1	No	Yes	5	5	2	1
R:R:W124	R:R:W134	9.37	1	Yes	Yes	7	5	2	1
L:L:?1	R:R:W134	5.56	1	Yes	Yes	0	5	0	1
R:R:D138	R:R:V142	4.38	1	Yes	No	7	6	1	1
R:R:D138	R:R:Y367	10.34	1	Yes	Yes	7	8	1	1
L:L:?1	R:R:D138	19.87	1	Yes	Yes	0	7	0	1
R:R:V139	R:R:Y224	3.79	0	No	Yes	7	7	1	2
L:L:?1	R:R:V139	14.54	1	Yes	No	0	7	0	1
R:R:V142	R:R:W337	12.26	1	No	Yes	6	8	1	1
L:L:?1	R:R:V142	9.69	1	Yes	No	0	6	0	1
R:R:S232	R:R:T143	9.59	0	No	No	7	7	1	2
R:R:F218	R:R:W199	9.02	1	Yes	Yes	6	6	1	2
R:R:T220	R:R:W199	8.49	1	No	Yes	5	6	2	2
R:R:W199	R:R:Y224	11.58	1	Yes	Yes	6	7	2	2
R:R:F218	R:R:T220	5.19	1	Yes	No	6	5	1	2
R:R:F218	R:R:N344	4.83	1	Yes	Yes	6	6	1	1
R:R:F218	R:R:F359	6.43	1	Yes	Yes	6	5	1	2
L:L:?1	R:R:F218	19.81	1	Yes	Yes	0	6	0	1
R:R:S228	R:R:Y224	15.26	0	No	Yes	6	7	1	2
L:L:?1	R:R:S228	7.33	1	Yes	No	0	6	0	1
R:R:F341	R:R:S229	7.93	1	Yes	No	7	7	1	2
R:R:N344	R:R:S229	5.96	1	Yes	No	6	7	1	2
L:L:?1	R:R:S232	4.88	1	Yes	No	0	7	0	1
R:R:F233	R:R:F333	6.43	1	Yes	Yes	8	9	2	2
R:R:F233	R:R:W337	4.01	1	Yes	Yes	8	8	2	1
R:R:F233	R:R:F341	27.86	1	Yes	Yes	8	7	2	1
R:R:F333	R:R:W337	4.01	1	Yes	Yes	9	8	2	1
R:R:F340	R:R:W337	7.02	1	Yes	Yes	7	8	1	1
R:R:F341	R:R:W337	11.02	1	Yes	Yes	7	8	1	1
R:R:G366	R:R:W337	11.26	0	No	Yes	7	8	2	1
R:R:N369	R:R:W337	6.78	0	No	Yes	9	8	2	1
L:L:?1	R:R:W337	3.71	1	Yes	Yes	0	8	0	1
R:R:F340	R:R:F341	9.65	1	Yes	Yes	7	7	1	1
R:R:F340	R:R:N344	14.5	1	Yes	Yes	7	6	1	1
R:R:F340	R:R:F359	10.72	1	Yes	Yes	7	5	1	2
R:R:F340	R:R:N363	14.5	1	Yes	No	7	6	1	1
L:L:?1	R:R:F340	11.89	1	Yes	Yes	0	7	0	1
R:R:F341	R:R:N344	4.83	1	Yes	Yes	7	6	1	1
L:L:?1	R:R:F341	14.86	1	Yes	Yes	0	7	0	1
R:R:F359	R:R:N344	6.04	1	Yes	Yes	5	6	2	1
L:L:?1	R:R:N344	4.47	1	Yes	Yes	0	6	0	1
R:R:N363	R:R:Y367	15.12	1	No	Yes	6	8	1	1
L:L:?1	R:R:N363	16.75	1	Yes	No	0	6	0	1
R:R:W364	R:R:Y367	14.47	1	Yes	Yes	7	8	2	1
L:L:?1	R:R:Y367	5.72	1	Yes	Yes	0	8	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8S2T_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.68
Number of Linked Nodes	268
Number of Links	316
Number of Hubs	52
Number of Links mediated by Hubs	194
Number of Communities	9
Number of Nodes involved in Communities	74
Number of Links involved in Communities	110

Path Summary
Number Of Nodes in MetaPath	90
Number Of Links MetaPath	89
Number of Shortest Paths	60986
Length Of Smallest Path	3
Average Path Length	12.1633
Length of Longest Path	28
Minimum Path Strength	1.21
Average Path Strength	6.954
Maximum Path Strength	21.36
Minimum Path Correlation	0.7
Average Path Correlation	0.93328
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	57.7519
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.349
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • protein binding • binding • PDZ domain binding • protein domain specific binding • protein heterodimerization activity • protein dimerization activity • beta1-adrenergic receptor activity • adrenergic receptor binding • signaling receptor binding • G protein-coupled receptor binding • alpha-2A adrenergic receptor binding • multicellular organismal process • response to nutrient levels • multicellular organismal-level homeostasis • response to stimulus • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus
Gene Ontology	Biological Process	• multicellular organismal process • response to nutrient levels • multicellular organismal-level homeostasis • response to stimulus • homeostatic process • response to dietary excess • diet induced thermogenesis • temperature homeostasis • energy homeostasis • adaptive thermogenesis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • heart process • system process • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of heart contraction • regulation of system process • positive regulation of biological process • positive regulation of blood pressure • positive regulation of blood circulation • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • circulatory system process • positive regulation of blood pressure by epinephrine-norepinephrine • regulation of multicellular organismal process • regulation of biological quality • blood circulation • regulation of heart rate • regulation of biological process • regulation of blood pressure • biological regulation • positive regulation of heart rate • positive regulation of heart rate by epinephrine-norepinephrine • positive regulation of heart contraction • regulation of blood circulation • regulation of systemic arterial blood pressure • positive regulation of multicellular organismal process • heart contraction • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • behavior • circadian behavior • sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • fear response • multicellular organismal response to stress • positive regulation of cardiac muscle cell apoptotic process • regulation of cellular process • positive regulation of programmed cell death • muscle cell apoptotic process • positive regulation of striated muscle cell apoptotic process • regulation of apoptotic process • regulation of cardiac muscle cell apoptotic process • regulation of muscle cell apoptotic process • regulation of programmed cell death • cell death • positive regulation of apoptotic process • cardiac muscle cell apoptotic process • positive regulation of muscle cell apoptotic process • regulation of striated muscle cell apoptotic process • striated muscle cell apoptotic process • cellular process • apoptotic process • programmed cell death • positive regulation of cellular process • developmental process • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • regulation of developmental process • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • negative regulation of multicellular organismal process • cellular response to stimulus • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • regulation of cold-induced thermogenesis • cold-induced thermogenesis • positive regulation of cold-induced thermogenesis • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • regulation of the force of heart contraction by chemical signal • regulation of the force of heart contraction • positive regulation of the force of heart contraction by chemical signal • positive regulation of the force of heart contraction by epinephrine-norepinephrine • regulation of tube diameter • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • regulation of anatomical structure size • heat generation • membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • dense core granule • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cellular anatomical structure • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • neuronal dense core vesicle • cell periphery • plasma membrane • membrane • early endosome • endosome • Schaffer collateral - CA1 synapse • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • cytosol • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • neuromuscular process • regulation of system process • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • serotonin receptor signaling pathway • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • trans-Golgi network
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	5FW
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	5FW
Name	ISOPRENALINE
Synonyms
Identifier
Formula	C11 H17 N O3
Molecular Weight	211.258
SMILES
PubChem	443372
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P08588
Sequence	>8S2T_nogp_Chain_R Q Q W T A G M G L L M A L I V L L I V A G N V L V I V A I A T P R L Q T L T N L F I M S L A S A D L V G L L V V P F G A T I V V W G R W E Y G S F F C E L W T S V D V L C V T A S T L C V I A L D R Y L A I T S P F R Y Q S L L T R A R A R G L V C T V W A I S A L V S F L P I L M H W W R A E S D E A R R C Y N D P K C C D F V T N R A Y A I A S S V V S F Y V P L C I M A F V Y L R V F R E A Q K Q V K K I D S C E R R F E Q K A L K T L G I I M G V F T L C W L P F F L A N V V K A F H R E L V P D R L F V F N W L G Y A N S A N P I I Y C R S P D F R K A F Q G L L S V V W A M A Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	2VT4	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.7	2008-06-24	doi.org/10.1038/nature07101
	2Y00	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.5	2011-01-12	doi.org/10.1038/nature09746
	2Y02	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carmoterol	-	-	2.6	2011-01-12	doi.org/10.1038/nature09746
	2Y03	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.85	2011-01-12	doi.org/10.1038/nature09746
	2Y04	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	3.05	2011-01-12	doi.org/10.1038/nature09746
	2Y01	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.6	2011-03-30	doi.org/10.1038/nature09746
	2YCW	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carazolol	-	-	3	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCX	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.25	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCZ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Iodocyanopindolol	-	-	3.65	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCY	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.15	2011-06-08	doi.org/10.1073/pnas.1100185108
	4AMI	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Bucindolol	-	-	3.2	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	4AMJ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carvedilol	-	-	2.3	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	4GPO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	-	-	-	3.5	2013-02-27	doi.org/10.1038/nsmb.2504
	3ZPQ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	PubChem 594590	Na	-	2.8	2013-04-03	doi.org/10.1021/jm400140q
	3ZPR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	PubChem 598754	Na	-	2.7	2013-04-03	doi.org/10.1021/jm400140q
	4BVN	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	Na	-	2.1	2014-04-02	doi.org/10.1371/journal.pone.0092727
	5A8E	A	Amine	Adrenergic	β₁	Meleagris gallopavo	7-Methylcyanopindolol	Na	-	2.4	2015-09-30	doi.org/10.1124/mol.115.101030
	5F8U	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.35	2015-12-23	doi.org/10.1038/nsmb.3130
	6H7J	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	6H7L	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.7	2018-10-17	doi.org/10.1126/science.aau5595
	6H7M	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	2.76	2018-10-17	doi.org/10.1126/science.aau5595
	6H7N	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Xamoterol	-	-	2.5	2018-10-17	doi.org/10.1101/436212
	6H7O	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	6IBL	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	-	2.7	2019-01-09	doi.org/10.1038/s41586-020-2419-1
	6TKO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	Arrestin2	3.3	2020-06-17	doi.org/10.1038/s41586-020-2419-1
	7JJO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gs/β1/γ2	2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	7JJO (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	7BTS	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	-	-	3.13	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU6	A	Amine	Adrenergic	β₁	Homo sapiens	Norepinephrine	-	-	2.7	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU7	A	Amine	Adrenergic	β₁	Homo sapiens	BI167107	-	-	2.6	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BVQ	A	Amine	Adrenergic	β₁	Homo sapiens	Carazolol	-	-	2.5	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7S0F	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gi1/β1/γ2	2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0F (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	chim(Gi1-CtGs)/β1/γ2	3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	8DCR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	Gs/β1/γ2	2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCR (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-		2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	Gs/β1/γ2	2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-		2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8S2T	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-05-21	To be published
	8S2T (No Gprot)	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-		3.3	2025-05-21	To be published
	9L84	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	Atazanavir	Gs/β1/γ2	3.22	2025-12-31	To be published
	9L84 (No Gprot)	A	Amine	Adrenergic	β₁	Homo sapiens	Epinephrine	Atazanavir		3.22	2025-12-31	To be published

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