psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L47	R:R:M44	5.65	No	No	0	5	4
2	R:R:A99	R:R:M48	4.83	No	No	0	6	6
3	R:R:G91	R:R:I55	3.53	No	No	0	7	7
4	R:R:D87	R:R:N59	8.08	Yes	No	0	9	9
5	R:R:N59	R:R:P340	4.89	No	No	0	9	9
6	R:R:F353	R:R:L61	14.61	No	No	0	7	6
7	R:R:A84	R:R:V62	3.39	No	No	0	8	9
8	R:R:C344	R:R:V62	5.12	No	No	0	6	9
9	R:R:I66	R:R:T81	6.08	No	No	0	7	5
10	R:R:F349	R:R:I66	3.77	Yes	No	0	8	7
11	R:R:R355	R:R:T69	7.76	No	Yes	0	4	6
12	R:R:Q70	R:R:Q73	19.2	No	No	0	6	7
13	R:R:L72	R:R:N77	4.12	Yes	No	3	8	9
14	R:R:D348	R:R:L72	4.07	No	Yes	0	6	8
15	R:R:F349	R:R:L72	8.53	Yes	Yes	3	8	8
16	R:R:N77	R:R:T74	14.62	No	No	0	9	7
17	R:R:D138	R:R:T76	4.34	Yes	No	0	9	8
18	R:R:F349	R:R:N77	4.83	Yes	No	3	8	9
19	R:R:K159	R:R:L78	5.64	No	Yes	0	4	5
20	R:R:I162	R:R:L78	4.28	No	Yes	0	7	5
21	R:R:F79	R:R:V134	3.93	Yes	No	0	8	5
22	R:R:F79	R:R:I135	3.77	Yes	No	0	8	9
23	R:R:D138	R:R:F79	3.58	Yes	Yes	0	9	8
24	R:R:F79	R:R:I162	5.02	Yes	No	0	8	7
25	R:R:I80	R:R:Y343	3.63	No	Yes	0	7	9
26	R:R:S82	R:R:T131	4.8	No	No	0	9	8
27	R:R:S82	R:R:W166	4.94	No	Yes	0	9	9
28	R:R:D87	R:R:L83	5.43	Yes	Yes	2	9	9
29	R:R:L83	R:R:T131	4.42	Yes	No	0	9	8
30	R:R:L132	R:R:L83	6.92	No	Yes	2	8	9
31	R:R:L83	R:R:N339	6.87	Yes	Yes	2	9	9
32	R:R:D87	R:R:S128	5.89	Yes	No	0	9	9
33	R:R:D87	R:R:S336	10.31	Yes	No	0	9	9
34	R:R:D87	R:R:N339	6.73	Yes	Yes	2	9	9
35	R:R:L88	R:R:L92	6.92	No	No	0	7	5
36	R:R:C124	R:R:V89	3.42	No	No	0	6	6
37	R:R:G91	R:R:V90	3.68	No	No	0	7	8
38	R:R:C124	R:R:V90	3.42	No	No	0	6	8
39	R:R:S336	R:R:V90	6.46	No	No	0	9	8
40	R:R:L120	R:R:L93	4.15	No	No	0	5	4
41	R:R:D121	R:R:V94	7.3	Yes	No	1	7	7
42	R:R:V94	R:R:Y333	3.79	No	Yes	1	7	7
43	R:R:P96	R:R:V95	3.53	No	No	0	9	7
44	R:R:V95	R:R:W330	3.68	No	Yes	0	7	6
45	R:R:F97	R:R:W107	5.01	No	Yes	1	4	7
46	R:R:F97	R:R:W117	8.02	No	Yes	1	4	6
47	R:R:G98	R:R:W117	4.22	No	Yes	0	6	6
48	R:R:T100	R:R:W109	8.49	No	Yes	0	4	5
49	R:R:L108	R:R:R104	6.07	No	No	0	4	4
50	R:R:G197	R:R:T106	3.64	No	No	0	4	3
51	R:R:W107	R:R:W109	4.69	Yes	Yes	1	7	5
52	R:R:L113	R:R:W107	3.42	No	Yes	1	4	7
53	R:R:C114	R:R:W107	7.84	No	Yes	1	9	7
54	R:R:W107	R:R:W117	5.62	Yes	Yes	1	7	6
55	R:R:C199	R:R:W107	7.84	No	Yes	1	9	7
56	R:R:L108	R:R:W109	3.42	No	Yes	0	4	5
57	R:R:L113	R:R:W109	5.69	No	Yes	1	4	5
58	R:R:E115	R:R:S111	4.31	No	No	0	6	4
59	R:R:C114	R:R:C199	7.28	No	No	1	9	9
60	R:R:E115	R:R:H180	9.85	No	No	5	6	5
61	R:R:E115	R:R:R183	4.65	No	Yes	5	6	4
62	R:R:T118	R:R:W117	3.64	No	Yes	0	6	6
63	L:L:?1	R:R:W117	6.48	Yes	Yes	1	0	6
64	R:R:F174	R:R:S119	9.25	Yes	No	0	5	6
65	R:R:I177	R:R:S119	10.84	No	No	0	6	6
66	R:R:D121	R:R:V125	4.38	Yes	No	1	7	6
67	R:R:D121	R:R:Y333	12.64	Yes	Yes	1	7	7
68	L:L:?1	R:R:D121	18.76	Yes	Yes	1	0	7
69	L:L:?1	R:R:V122	13.33	Yes	No	0	0	6
70	R:R:L123	R:R:S169	4.5	Yes	No	0	5	8
71	R:R:L123	R:R:S173	6.01	Yes	No	0	5	7
72	R:R:F174	R:R:L123	4.87	Yes	Yes	0	5	5
73	R:R:V125	R:R:W303	9.81	No	Yes	1	6	8
74	L:L:?1	R:R:V125	8.48	Yes	No	1	0	6
75	R:R:E130	R:R:T126	4.23	No	No	0	6	6
76	R:R:S169	R:R:T126	6.4	No	No	0	8	6
77	R:R:S215	R:R:T126	7.99	No	No	0	6	6
78	R:R:A127	R:R:W166	7.78	No	Yes	0	7	9
79	R:R:A127	R:R:S169	3.42	No	No	0	7	8
80	R:R:I129	R:R:P219	3.39	No	No	0	8	9
81	R:R:F299	R:R:I129	6.28	No	No	0	9	8
82	R:R:I129	R:R:W303	10.57	No	Yes	0	8	8
83	R:R:E130	R:R:V165	5.7	No	No	0	6	6
84	R:R:E130	R:R:I168	4.1	No	No	0	6	4
85	R:R:L132	R:R:N339	10.98	No	Yes	2	8	9
86	R:R:L132	R:R:Y343	5.86	No	Yes	0	8	9
87	R:R:C133	R:R:I222	6.55	No	No	0	6	6
88	R:R:I135	R:R:R139	3.76	No	No	0	9	9
89	R:R:A136	R:R:Y227	6.67	No	Yes	0	8	9
90	R:R:D138	R:R:Y149	11.49	Yes	No	4	9	7
91	R:R:D138	R:R:M153	4.16	Yes	No	4	9	6
92	R:R:R139	R:R:Y227	5.14	No	Yes	0	9	9
93	R:R:R139	R:R:Y343	6.17	No	Yes	0	9	9
94	R:R:T144	R:R:Y140	13.73	No	Yes	0	7	8
95	R:R:V226	R:R:Y140	6.31	No	Yes	0	6	8
96	R:R:R229	R:R:Y140	11.32	Yes	Yes	0	5	8
97	R:R:A142	R:R:Y149	8.01	No	No	0	8	7
98	R:R:S145	R:R:T144	4.8	No	No	0	6	7
99	R:R:E233	R:R:T144	4.23	No	No	0	6	7
100	R:R:F147	R:R:P146	7.22	No	No	0	6	8
101	R:R:M153	R:R:Y149	11.97	No	No	4	6	7
102	R:R:L152	R:R:S151	4.5	No	No	0	5	5
103	R:R:R157	R:R:T154	3.88	No	No	0	7	8
104	R:R:I214	R:R:V172	7.68	No	No	0	4	5
105	R:R:F174	R:R:M178	6.22	Yes	No	0	5	4
106	R:R:P176	R:R:Y207	5.56	No	Yes	0	7	7
107	R:R:I177	R:R:W182	3.52	No	Yes	0	6	5
108	R:R:I177	R:R:Y207	4.84	No	Yes	0	6	7
109	R:R:M179	R:R:W181	19.78	No	No	0	5	6
110	R:R:H180	R:R:R183	19.18	No	Yes	5	5	4
111	R:R:R183	R:R:W182	5	Yes	Yes	0	4	5
112	R:R:F201	R:R:W182	5.01	No	Yes	0	4	5
113	R:R:T203	R:R:W182	3.64	Yes	Yes	0	4	5
114	R:R:R183	R:R:Y193	17.49	Yes	No	0	4	3
115	R:R:A189	R:R:D184	4.63	No	No	7	4	4
116	R:R:D184	R:R:Y193	12.64	No	No	0	4	3
117	R:R:D184	R:R:V202	4.38	No	Yes	7	4	4
118	R:R:D186	R:R:P187	6.44	No	No	0	1	1
119	R:R:A189	R:R:V202	5.09	No	Yes	7	4	4
120	R:R:K191	R:R:L190	9.87	No	No	0	3	1
121	R:R:C192	R:R:C198	7.28	No	No	0	4	5
122	R:R:D195	R:R:P196	8.05	No	No	0	3	3
123	R:R:D195	R:R:G197	5.03	No	No	0	3	4
124	R:R:C198	R:R:D200	6.22	No	No	0	5	5
125	L:L:?1	R:R:F201	17.83	Yes	No	0	0	4
126	R:R:R317	R:R:V202	6.54	No	Yes	0	1	4
127	R:R:N204	R:R:T203	4.39	No	Yes	0	5	4
128	R:R:T203	R:R:Y207	3.75	Yes	Yes	0	4	7
129	R:R:A208	R:R:T203	3.36	No	Yes	0	6	4
130	R:R:I209	R:R:R205	3.76	No	No	0	5	5
131	R:R:R205	R:R:V314	9.15	No	No	0	5	5
132	R:R:F315	R:R:R205	7.48	No	No	0	5	5
133	R:R:S211	R:R:Y207	6.36	No	Yes	0	6	7
134	L:L:?1	R:R:S211	9.77	Yes	No	0	0	6
135	R:R:F307	R:R:S212	3.96	Yes	No	0	7	6
136	R:R:N310	R:R:S212	5.96	Yes	No	0	6	6
137	R:R:F307	R:R:S215	6.61	Yes	No	1	7	6
138	L:L:?1	R:R:S215	3.66	Yes	No	1	0	6
139	R:R:F216	R:R:Y217	5.16	Yes	No	0	7	5
140	R:R:F216	R:R:L220	6.09	Yes	No	0	7	6
141	R:R:F216	R:R:F299	9.65	Yes	No	0	7	9
142	R:R:F216	R:R:W303	5.01	Yes	Yes	1	7	8
143	R:R:F216	R:R:L304	7.31	Yes	Yes	0	7	7
144	R:R:F216	R:R:F307	19.29	Yes	Yes	1	7	7
145	R:R:I311	R:R:Y217	4.84	No	No	0	5	5
146	R:R:I218	R:R:P219	3.39	No	No	0	5	9
147	R:R:I224	R:R:L220	4.28	No	No	0	5	6
148	R:R:M223	R:R:Y227	4.79	No	Yes	6	8	9
149	R:R:M223	R:R:M296	4.33	No	No	6	8	8
150	R:R:F299	R:R:M223	4.98	No	No	0	9	8
151	R:R:I224	R:R:M296	4.37	No	No	0	5	8
152	R:R:L292	R:R:Y227	3.52	No	Yes	0	8	9
153	R:R:I295	R:R:Y227	3.63	No	Yes	0	8	9
154	R:R:M296	R:R:Y227	4.79	No	Yes	6	8	9
155	R:R:R229	R:R:R232	5.33	Yes	No	0	5	4
156	R:R:E233	R:R:R229	6.98	No	Yes	0	6	5
157	R:R:K235	R:R:Y231	9.55	No	No	0	5	6
158	R:R:L289	R:R:Y231	11.72	No	No	0	7	6
159	R:R:L292	R:R:Y231	3.52	No	No	0	8	6
160	R:R:I238	R:R:R284	3.76	No	No	0	5	6
161	R:R:I342	R:R:V298	4.61	No	No	0	8	6
162	R:R:L304	R:R:T300	4.42	Yes	No	0	7	5
163	R:R:C302	R:R:N335	6.3	No	No	0	8	9
164	R:R:F306	R:R:W303	5.01	Yes	Yes	1	7	8
165	R:R:F307	R:R:W303	7.02	Yes	Yes	1	7	8
166	R:R:G332	R:R:W303	8.44	No	Yes	0	6	8
167	R:R:N335	R:R:W303	5.65	No	Yes	0	9	8
168	R:R:L304	R:R:L308	8.3	Yes	No	0	7	6
169	R:R:F328	R:R:P305	5.78	No	No	0	5	9
170	R:R:F306	R:R:F307	12.86	Yes	Yes	1	7	7
171	R:R:F306	R:R:N310	4.83	Yes	Yes	1	7	6
172	R:R:F306	R:R:F325	7.5	Yes	No	1	7	4
173	R:R:F306	R:R:N329	13.29	Yes	No	1	7	6
174	L:L:?1	R:R:F306	8.92	Yes	Yes	1	0	7
175	L:L:?1	R:R:F307	7.92	Yes	Yes	1	0	7
176	R:R:N313	R:R:V309	4.43	No	No	0	4	4
177	R:R:V309	R:R:V320	8.02	No	No	0	4	5
178	R:R:F325	R:R:N310	3.62	No	Yes	1	4	6
179	L:L:?1	R:R:N310	5.58	Yes	Yes	1	0	6
180	R:R:N313	R:R:R317	6.03	No	No	0	4	1
181	R:R:F325	R:R:N313	8.46	No	No	0	4	4
182	R:R:L319	R:R:N316	5.49	No	No	0	6	4
183	R:R:P321	R:R:V320	3.53	No	No	0	5	5
184	R:R:P321	R:R:W323	6.76	No	No	0	5	3
185	R:R:L324	R:R:W323	11.39	No	No	0	4	3
186	R:R:F327	R:R:F328	5.36	No	No	0	5	5
187	R:R:F327	R:R:L331	13.4	No	No	0	5	7
188	R:R:N329	R:R:Y333	12.79	No	Yes	1	6	7
189	L:L:?1	R:R:N329	15.63	Yes	No	1	0	6
190	R:R:W330	R:R:Y333	10.61	Yes	Yes	0	6	7
191	L:L:?1	R:R:Y333	6.67	Yes	Yes	1	0	7
192	R:R:N335	R:R:N339	12.26	No	Yes	0	9	9
193	R:R:I342	R:R:Y343	4.84	No	Yes	0	8	9
194	R:R:C344	R:R:F349	13.97	No	Yes	0	6	8
195	R:R:P347	R:R:S346	5.34	No	No	0	6	8
196	R:R:D348	R:R:S346	5.89	No	No	0	6	8
197	R:R:K354	R:R:R350	11.14	No	No	0	4	8
198	R:R:K351	R:R:K354	5.75	No	No	0	4	4
199	R:R:L304	R:R:P305	3.28	Yes	No	0	7	9
200	R:R:C133	R:R:I137	3.27	No	No	0	6	6
201	R:R:A337	R:R:I55	3.25	No	No	0	6	7
202	R:R:V312	R:R:V320	3.21	No	No	0	5	5
203	R:R:F353	R:R:R350	3.21	No	No	0	7	8
204	R:R:T74	R:R:T76	3.14	No	No	0	7	8
205	R:R:I161	R:R:V134	3.07	No	No	0	6	5
206	R:R:I143	R:R:V230	3.07	No	No	0	9	9
207	R:R:L92	R:R:V56	2.98	No	No	0	5	6
208	R:R:L171	R:R:V172	2.98	No	No	0	4	5
209	R:R:L72	R:R:T69	2.95	Yes	Yes	0	8	6
210	R:R:L108	R:R:T106	2.95	No	No	0	4	3
211	R:R:I209	R:R:I213	2.94	No	No	0	5	4
212	R:R:I213	R:R:I214	2.94	No	No	0	4	4
213	R:R:I213	R:R:I218	2.94	No	No	0	4	5
214	R:R:I218	R:R:I222	2.94	No	No	0	5	6
215	R:R:I294	R:R:I342	2.94	No	No	0	7	8
216	R:R:I137	R:R:L141	2.85	No	No	0	6	5
217	R:R:I224	R:R:L228	2.85	No	No	0	5	2
218	R:R:G110	R:R:W107	2.81	No	Yes	0	7	7
219	R:R:L356	R:R:L61	2.77	No	No	0	6	6
220	R:R:L92	R:R:L93	2.77	No	No	0	5	4
221	R:R:A334	R:R:F338	2.77	No	No	0	4	6
222	R:R:A352	R:R:R355	2.77	No	No	0	7	4
223	R:R:E236	R:R:K240	2.7	No	No	0	4	5
224	R:R:R148	R:R:S145	2.64	No	No	0	5	6
225	R:R:F338	R:R:V298	2.62	No	No	0	6	6
226	R:R:R71	R:R:T69	2.59	No	Yes	0	5	6
227	R:R:A86	R:R:W166	2.59	No	Yes	0	8	9
228	R:R:A99	R:R:W330	2.59	No	Yes	0	6	6
229	R:R:R345	R:R:T291	2.59	No	No	0	7	8
230	R:R:V230	R:R:Y140	2.52	No	Yes	0	9	8
231	R:R:V226	R:R:Y227	2.52	No	Yes	0	6	9
232	R:R:I241	R:R:R284	2.51	No	No	0	5	6
233	R:R:I294	R:R:R345	2.51	No	No	0	7	7
234	R:R:F338	R:R:I341	2.51	No	No	0	6	6
235	R:R:V326	R:R:W330	2.45	No	Yes	0	4	6
236	R:R:F112	R:R:L116	2.44	No	No	0	2	4
237	R:R:F174	R:R:L120	2.44	Yes	No	0	5	5
238	R:R:Q194	R:R:Y193	2.25	No	No	0	3	3
239	R:R:F225	R:R:R229	2.14	No	Yes	0	5	5
240	R:R:G58	R:R:P340	2.03	No	No	0	8	9
241	R:R:A57	R:R:G58	1.95	No	No	0	4	8
242	R:R:G91	R:R:V52	1.84	No	No	0	7	5
243	R:R:G297	R:R:T300	1.82	No	No	0	5	5
244	R:R:A352	R:R:A65	1.79	No	No	0	7	7
245	R:R:P146	R:R:S145	1.78	No	No	0	8	6
246	R:R:G98	R:R:L101	1.71	No	No	0	6	5
247	R:R:A156	R:R:T154	1.68	No	No	0	5	8
248	R:R:G67	R:R:Q73	1.64	No	No	0	2	7
249	R:R:L175	R:R:P176	1.64	No	No	0	6	7
250	R:R:L190	R:R:P187	1.64	No	No	0	1	1
251	R:R:S45	R:R:V103	1.62	No	No	0	5	5
252	R:R:A84	R:R:I63	1.62	No	No	0	8	7
253	R:R:V56	R:R:V60	1.6	No	No	0	6	3
254	R:R:S68	R:R:T69	1.6	No	Yes	0	5	6
255	R:R:T164	R:R:V160	1.59	No	No	0	3	3
256	R:R:A337	R:R:L54	1.58	No	No	0	6	5
257	R:R:A158	R:R:L78	1.58	No	Yes	0	7	5
258	R:R:A170	R:R:L123	1.58	No	Yes	0	3	5
259	R:R:A206	R:R:N204	1.56	No	No	0	4	5
260	R:R:I55	R:R:V51	1.54	No	No	0	7	6
261	R:R:I168	R:R:T164	1.52	No	No	0	4	3
262	R:R:G105	R:R:R104	1.5	No	No	0	4	4
263	R:R:K287	R:R:T291	1.5	No	No	0	8	8
264	R:R:L53	R:R:V52	1.49	No	No	0	5	5
265	R:R:D200	R:R:V202	1.46	No	Yes	0	5	4
266	R:R:I294	R:R:K290	1.45	No	No	0	7	7
267	R:R:L75	R:R:M153	1.41	No	No	0	6	6
268	R:R:L50	R:R:L53	1.38	No	No	0	4	5
269	R:R:K240	R:R:Q237	1.36	No	No	0	5	7
270	R:R:E285	R:R:K235	1.35	No	No	0	7	5
271	R:R:L72	R:R:Q73	1.33	Yes	No	0	8	7
272	R:R:C85	R:R:W166	1.31	No	Yes	0	5	9
273	R:R:R104	R:R:V103	1.31	No	No	0	4	5
274	R:R:R155	R:R:T154	1.29	No	No	0	3	8
275	R:R:E233	R:R:Q237	1.27	No	No	0	6	7
276	R:R:K351	R:R:R355	1.24	No	No	0	4	4
277	R:R:V102	R:R:W330	1.23	No	Yes	0	5	6
278	R:R:L75	R:R:R155	1.21	No	No	0	6	3
279	R:R:L78	R:R:R155	1.21	Yes	No	0	5	3
280	R:R:F147	R:R:Q150	1.17	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:T69	3.725	4	0	6
2	R:R:L72	4.2	5	3	8
3	R:R:L78	3.1775	4	0	5
4	R:R:F79	4.075	4	0	8
5	R:R:L83	5.91	4	2	9
6	R:R:D87	7.288	5	2	9
7	R:R:W107	5.31857	7	1	7
8	R:R:W109	5.5725	4	1	5
9	R:R:W117	5.596	5	1	6
10	R:R:D121	10.77	4	1	7
11	R:R:L123	4.24	4	0	5
12	R:R:D138	5.8925	4	4	9
13	R:R:Y140	8.47	4	0	8
14	R:R:W166	4.155	4	0	9
15	R:R:F174	5.695	4	0	5
16	R:R:W182	4.2925	4	0	5
17	R:R:R183	11.58	4	5	4
18	R:R:V202	4.3675	4	7	4
19	R:R:T203	3.785	4	0	4
20	R:R:Y207	5.1275	4	0	7
21	R:R:F216	8.75167	6	1	7
22	R:R:Y227	4.43714	7	6	9
23	R:R:R229	6.4425	4	0	5
24	R:R:W303	7.35857	7	1	8
25	R:R:L304	5.8275	4	0	7
26	R:R:F306	8.735	6	1	7
27	R:R:F307	9.61	6	1	7
28	R:R:N310	4.9975	4	1	6
29	R:R:W330	4.112	5	0	6
30	R:R:Y333	9.3	5	1	7
31	R:R:N339	9.21	4	2	9
32	R:R:Y343	5.125	4	0	9
33	R:R:F349	7.775	4	3	8
34	L:L:?1	10.2525	12	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:W330	R:R:Y333	24.6516	10.61	Yes	Yes	0	6	7
2	R:R:V125	R:R:W303	30.1466	9.81	No	Yes	1	6	8
3	R:R:N335	R:R:W303	72.6699	5.65	No	Yes	0	9	8
4	R:R:N335	R:R:N339	69.6937	12.26	No	Yes	0	9	9
5	R:R:D87	R:R:N339	44.4178	6.73	Yes	Yes	2	9	9
6	R:R:D87	R:R:S336	39.8011	10.31	Yes	No	0	9	9
7	R:R:S336	R:R:V90	36.5636	6.46	No	No	0	9	8
8	R:R:G91	R:R:V90	26.7639	3.68	No	No	0	7	8
9	L:L:?1	R:R:Y333	22.6336	6.67	Yes	Yes	1	0	7
10	L:L:?1	R:R:V125	21.944	8.48	Yes	No	1	0	6
11	R:R:F306	R:R:W303	59.3568	5.01	Yes	Yes	1	7	8
12	L:L:?1	R:R:F306	29.1449	8.92	Yes	Yes	1	0	7
13	L:L:?1	R:R:F307	61.7668	7.92	Yes	Yes	1	0	7
14	R:R:F307	R:R:W303	26.6986	7.02	Yes	Yes	1	7	8
15	R:R:G91	R:R:I55	13.4945	3.53	No	No	0	7	7
16	R:R:D87	R:R:N59	13.4945	8.08	Yes	No	0	9	9
17	R:R:N59	R:R:P340	10.1408	4.89	No	No	0	9	9
18	R:R:F216	R:R:F307	67.6249	19.29	Yes	Yes	1	7	7
19	R:R:F216	R:R:F299	78.7674	9.65	Yes	No	0	7	9
20	R:R:F299	R:R:M223	100	4.98	No	No	0	9	8
21	R:R:M223	R:R:Y227	97.9675	4.79	No	Yes	6	8	9
22	R:R:R139	R:R:Y227	84.2843	5.14	No	Yes	0	9	9
23	R:R:I135	R:R:R139	98.6353	3.76	No	No	0	9	9
24	R:R:F79	R:R:I135	96.8423	3.77	Yes	No	0	8	9
25	R:R:D138	R:R:F79	74.7822	3.58	Yes	Yes	0	9	8
26	R:R:D138	R:R:T76	65.8174	4.34	Yes	No	0	9	8
27	R:R:T74	R:R:T76	63.7268	3.14	No	No	0	7	8
28	R:R:N77	R:R:T74	61.5926	14.62	No	No	0	9	7
29	R:R:L72	R:R:N77	43.9315	4.12	Yes	No	3	8	9
30	R:R:L72	R:R:T69	28.7239	2.95	Yes	Yes	0	8	6
31	R:R:R355	R:R:T69	21.5738	7.76	No	Yes	0	4	6
32	R:R:K351	R:R:R355	14.6051	1.24	No	No	0	4	4
33	R:R:K351	R:R:K354	12.1516	5.75	No	No	0	4	4
34	R:R:F349	R:R:N77	15.4617	4.83	Yes	No	3	8	9
35	R:R:F79	R:R:I162	18.162	5.02	Yes	No	0	8	7
36	R:R:I162	R:R:L78	16.0569	4.28	No	Yes	0	7	5
37	R:R:L132	R:R:N339	43.7064	10.98	No	Yes	2	8	9
38	R:R:L132	R:R:Y343	63.9808	5.86	No	Yes	0	8	9
39	L:L:?1	R:R:S215	12.5871	3.66	Yes	No	1	0	6
40	R:R:S215	R:R:T126	31.8598	7.99	No	No	0	6	6
41	R:R:S169	R:R:T126	21.7117	6.4	No	No	0	8	6
42	R:R:A127	R:R:S169	13.5453	3.42	No	No	0	7	8
43	R:R:A127	R:R:W166	12.8484	7.78	No	Yes	0	7	9
44	R:R:S82	R:R:W166	11.8031	4.94	No	Yes	0	9	9
45	R:R:L83	R:R:T131	14.5906	4.42	Yes	No	0	9	8
46	L:L:?1	R:R:F201	35.6707	17.83	Yes	No	0	0	4
47	R:R:F201	R:R:W182	33.689	5.01	No	Yes	0	4	5
48	R:R:I177	R:R:W182	10.0973	3.52	No	Yes	0	6	5
49	R:R:I177	R:R:S119	13.6542	10.84	No	No	0	6	6
50	R:R:F174	R:R:L120	18.0677	2.44	Yes	No	0	5	5
51	R:R:L120	R:R:L93	15.0915	4.15	No	No	0	5	4
52	R:R:L92	R:R:L93	12.1008	2.77	No	No	0	5	4
53	L:L:?1	R:R:S211	26.0598	9.77	Yes	No	0	0	6
54	R:R:S211	R:R:Y207	23.8095	6.36	No	Yes	0	6	7
55	R:R:L123	R:R:S169	23.1925	4.5	Yes	No	0	5	8
56	R:R:F174	R:R:L123	17.9225	4.87	Yes	Yes	0	5	5
57	L:L:?1	R:R:W117	55.0378	6.48	Yes	Yes	1	0	6
58	R:R:W107	R:R:W117	42.6321	5.62	Yes	Yes	1	7	6
59	R:R:W107	R:R:W109	29.8127	4.69	Yes	Yes	1	7	5
60	R:R:L108	R:R:W109	24.5499	3.42	No	Yes	0	4	5
61	R:R:L108	R:R:R104	10.9393	6.07	No	No	0	4	4
62	R:R:L108	R:R:T106	11.1426	2.95	No	No	0	4	3
63	R:R:R183	R:R:W182	17.349	5	Yes	Yes	0	4	5
64	R:R:E130	R:R:T126	10.0102	4.23	No	No	0	6	6
65	R:R:I129	R:R:W303	44.563	10.57	No	Yes	0	8	8
66	R:R:I129	R:R:P219	39.7285	3.39	No	No	0	8	9
67	R:R:I218	R:R:P219	36.9846	3.39	No	No	0	5	9
68	R:R:I218	R:R:I222	11.6362	2.94	No	No	0	5	6
69	R:R:V226	R:R:Y227	45.1219	2.52	No	Yes	0	6	9
70	R:R:V226	R:R:Y140	43.1039	6.31	No	Yes	0	6	8
71	R:R:T144	R:R:Y140	21.748	13.73	No	Yes	0	7	8
72	R:R:R229	R:R:Y140	15.4689	11.32	Yes	Yes	0	5	8
73	R:R:S145	R:R:T144	11.3531	4.8	No	No	0	6	7
74	R:R:I213	R:R:I218	23.0473	2.94	No	No	0	4	5
75	R:R:T203	R:R:W182	10.4893	3.64	Yes	Yes	0	4	5
76	R:R:R317	R:R:V202	20.2889	6.54	No	Yes	0	1	4
77	R:R:N313	R:R:R317	23.8749	6.03	No	No	0	4	1
78	R:R:F325	R:R:N313	53.2448	8.46	No	No	0	4	4
79	R:R:F306	R:R:F325	49.833	7.5	Yes	No	1	7	4
80	R:R:D200	R:R:V202	11.0627	1.46	No	Yes	0	5	4
81	R:R:N204	R:R:T203	10.2279	4.39	No	Yes	0	5	4
82	R:R:T203	R:R:Y207	10.1916	3.75	Yes	Yes	0	4	7
83	R:R:I209	R:R:I213	11.6362	2.94	No	No	0	5	4
84	R:R:F216	R:R:L304	17.0078	7.31	Yes	Yes	0	7	7
85	R:R:L292	R:R:Y227	10.7796	3.52	No	Yes	0	8	9
86	R:R:I342	R:R:Y343	28.9925	4.84	No	Yes	0	8	9
87	R:R:I342	R:R:V298	11.8902	4.61	No	No	0	8	6
88	R:R:N313	R:R:V309	26.3429	4.43	No	No	0	4	4
89	R:R:V309	R:R:V320	21.9875	8.02	No	No	0	4	5
90	R:R:P321	R:R:V320	13.2332	3.53	No	No	0	5	5
91	R:R:E233	R:R:Q237	13.3638	1.27	No	No	0	6	7
92	R:R:I294	R:R:I342	14.4599	2.94	No	No	0	7	8
93	R:R:G91	R:R:V52	10.1408	1.84	No	No	0	7	5
94	R:R:R139	R:R:Y343	47.2851	6.17	No	Yes	0	9	9
95	R:R:L132	R:R:L83	21.8569	6.92	No	Yes	2	8	9
96	R:R:D87	R:R:L83	14.4962	5.43	Yes	Yes	2	9	9
97	R:R:S82	R:R:T131	12.304	4.8	No	No	0	9	8
98	R:R:F307	R:R:S215	20.9422	6.61	Yes	No	1	7	6
99	R:R:F299	R:R:I129	25.3992	6.28	No	No	0	9	8
100	R:R:F216	R:R:W303	21.2398	5.01	Yes	Yes	1	7	8
101	R:R:F306	R:R:F307	14.2349	12.86	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:D121	R:R:V94	7.3	1	Yes	No	7	7	1	2
R:R:V94	R:R:Y333	3.79	1	No	Yes	7	7	2	1
R:R:F97	R:R:W107	5.01	1	No	Yes	4	7	2	2
R:R:F97	R:R:W117	8.02	1	No	Yes	4	6	2	1
R:R:G98	R:R:W117	4.22	0	No	Yes	6	6	2	1
R:R:W107	R:R:W117	5.62	1	Yes	Yes	7	6	2	1
R:R:T118	R:R:W117	3.64	0	No	Yes	6	6	2	1
L:L:?1	R:R:W117	6.48	1	Yes	Yes	0	6	0	1
R:R:D121	R:R:V125	4.38	1	Yes	No	7	6	1	1
R:R:D121	R:R:Y333	12.64	1	Yes	Yes	7	7	1	1
L:L:?1	R:R:D121	18.76	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:V122	13.33	1	Yes	No	0	6	0	1
R:R:V125	R:R:W303	9.81	1	No	Yes	6	8	1	2
L:L:?1	R:R:V125	8.48	1	Yes	No	0	6	0	1
R:R:S215	R:R:T126	7.99	1	No	No	6	6	1	2
R:R:F201	R:R:W182	5.01	0	No	Yes	4	5	1	2
L:L:?1	R:R:F201	17.83	1	Yes	No	0	4	0	1
R:R:S211	R:R:Y207	6.36	0	No	Yes	6	7	1	2
L:L:?1	R:R:S211	9.77	1	Yes	No	0	6	0	1
R:R:F307	R:R:S212	3.96	1	Yes	No	7	6	1	2
R:R:N310	R:R:S212	5.96	1	Yes	No	6	6	1	2
R:R:F307	R:R:S215	6.61	1	Yes	No	7	6	1	1
L:L:?1	R:R:S215	3.66	1	Yes	No	0	6	0	1
R:R:F216	R:R:W303	5.01	1	Yes	Yes	7	8	2	2
R:R:F216	R:R:F307	19.29	1	Yes	Yes	7	7	2	1
R:R:F306	R:R:W303	5.01	1	Yes	Yes	7	8	1	2
R:R:F307	R:R:W303	7.02	1	Yes	Yes	7	8	1	2
R:R:F306	R:R:F307	12.86	1	Yes	Yes	7	7	1	1
R:R:F306	R:R:N310	4.83	1	Yes	Yes	7	6	1	1
R:R:F306	R:R:F325	7.5	1	Yes	No	7	4	1	2
R:R:F306	R:R:N329	13.29	1	Yes	No	7	6	1	1
L:L:?1	R:R:F306	8.92	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F307	7.92	1	Yes	Yes	0	7	0	1
R:R:F325	R:R:N310	3.62	1	No	Yes	4	6	2	1
L:L:?1	R:R:N310	5.58	1	Yes	Yes	0	6	0	1
R:R:N329	R:R:Y333	12.79	1	No	Yes	6	7	1	1
L:L:?1	R:R:N329	15.63	1	Yes	No	0	6	0	1
R:R:W330	R:R:Y333	10.61	0	Yes	Yes	6	7	2	1
L:L:?1	R:R:Y333	6.67	1	Yes	Yes	0	7	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7S0F_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.36
Number of Linked Nodes	255
Number of Links	280
Number of Hubs	34
Number of Links mediated by Hubs	136
Number of Communities	7
Number of Nodes involved in Communities	39
Number of Links involved in Communities	54

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	47036
Length Of Smallest Path	3
Average Path Length	12.3322
Length of Longest Path	31
Minimum Path Strength	1.25
Average Path Strength	6.33376
Maximum Path Strength	18.335
Minimum Path Correlation	0.7
Average Path Correlation	0.916816
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	49.144
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.7405
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cell periphery • cellular anatomical structure • plasma membrane • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • cyclase regulator activity • molecular function regulator activity • adenylate cyclase regulator activity • GTPase activating protein binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • protein localization to postsynaptic specialization membrane • protein localization to postsynaptic membrane • protein localization to cell periphery • cellular localization • protein localization to synapse • biological regulation • localization within membrane • protein localization to membrane • protein-containing complex localization • neurotransmitter receptor localization to postsynaptic specialization membrane • localization • regulation of postsynaptic membrane neurotransmitter receptor levels • macromolecule localization • protein localization to organelle • cellular process • protein localization to postsynapse • intracellular protein localization • regulation of biological quality • protein localization to cell junction • receptor localization to synapse • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • regulation of localization • regulation of protein localization • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to hormone • response to chemical • response to endogenous stimulus • response to alcohol • response to prostaglandin E • response to oxygen-containing compound • trans-synaptic signaling • regulation of signaling • negative regulation of signaling • modulation of chemical synaptic transmission • negative regulation of biological process • cell-cell signaling • negative regulation of synaptic transmission • negative regulation of cell communication • chemical synaptic transmission • synaptic signaling • regulation of trans-synaptic signaling • anterograde trans-synaptic signaling • negative regulation of cellular process • regulation of cell communication • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • cell cortex • intracellular anatomical structure • cytoplasm • intracellular organelle • centrosome • microtubule organizing center • cytoskeleton • organelle • membraneless organelle • intracellular membraneless organelle • microtubule cytoskeleton • cytosol • synapse • cell junction • glutamatergic synapse • postsynapse • membrane-bounded organelle • nucleus • intracellular membrane-bounded organelle • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • phospholipase C-activating G protein-coupled receptor signaling pathway • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta1-adrenergic receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • identical protein binding • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • rhythmic process • circadian sleep/wake cycle, sleep • circadian sleep/wake cycle • rhythmic behavior • regulation of circadian sleep/wake cycle • circadian rhythm • regulation of circadian rhythm • regulation of behavior • behavior • circadian behavior • regulation of multicellular organismal process • sleep • regulation of circadian sleep/wake cycle, sleep • circadian sleep/wake cycle process • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • heart process • regulation of heart contraction • regulation of system process • positive regulation of blood circulation • positive regulation of heart contraction • regulation of blood circulation • positive regulation of multicellular organismal process • heart contraction • early endosome • endosome • intracellular vesicle • endomembrane system • cytoplasmic vesicle • vesicle
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • WD40 repeat-like • G protein-coupled receptor-like
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases • WD40 repeat-like • G protein-coupled receptor-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	5FW
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	5FW
Name	ISOPRENALINE
Synonyms
Identifier
Formula	C11 H17 N O3
Molecular Weight	211.258
SMILES
PubChem	443372
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P07700
Sequence	>7S0F_nogp_Chain_R M S L L M A L V V L L I V A G N V L V I A A I G S T Q R L Q T L T N L F I T S L A C A D L V V G L L V V P F G A T L V V R G T W L W G S F L C E L W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S P F R Y Q S L M T R A R A K V I I C T V W A I S A L V S F L P I M M H W W R D E D P Q A L K C Y Q D P G C C D F V T N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N R D L V P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F R K A F K R L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3ZPQ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	4-(piperazin-1- yl)-1H-indole	Na	-	2.8	2013-04-03	doi.org/10.1021/jm400140q
	3ZPR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	4-methyl-2-(piperazin-1-yl)	Na	-	2.7	2013-04-03	doi.org/10.1021/jm400140q
	5A8E	A	Amine	Adrenergic	β₁	Meleagris gallopavo	7-Methylcyanopindolol	Na	-	2.4	2015-09-30	doi.org/10.1124/mol.115.101030
	4BVN	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	Na	-	2.1	2014-04-02	doi.org/10.1371/journal.pone.0092727
	7JJO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gs/β1/γ2	2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	7JJO (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.6	2020-09-02	doi.org/10.1016/j.molcel.2020.08.001
	4AMI	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Bucindolol	-	-	3.2	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	4AMJ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	S-Carvedilol	-	-	2.3	2012-05-23	doi.org/10.1016/j.str.2012.03.014
	2VT4	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.7	2008-06-24	doi.org/10.1038/nature07101
	2Y00	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.5	2011-01-12	doi.org/10.1038/nature09746
	2Y02	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Carmoterol	-	-	2.6	2011-01-12	doi.org/10.1038/nature09746
	2Y03	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.85	2011-01-12	doi.org/10.1038/nature09746
	2Y04	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	3.05	2011-01-12	doi.org/10.1038/nature09746
	2Y01	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.6	2011-03-30	doi.org/10.1038/nature09746
	4GPO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	-	-	-	3.5	2013-02-27	doi.org/10.1038/nsmb.2504
	5F8U	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.35	2015-12-23	doi.org/10.1038/nsmb.3130
	7BTS	A	Amine	Adrenergic	β₁	Homo sapiens	L-Epinephrine	-	-	3.13	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU6	A	Amine	Adrenergic	β₁	Homo sapiens	L-Norepinephrine	-	-	2.7	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BU7	A	Amine	Adrenergic	β₁	Homo sapiens	BI167107	-	-	2.6	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	7BVQ	A	Amine	Adrenergic	β₁	Homo sapiens	S-Carazolol	-	-	2.5	2020-12-02	doi.org/10.1038/s41422-020-00424-2
	8DCR	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	Gs/β1/γ2	2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCR (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-		2.6	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	Gs/β1/γ2	2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	8DCS (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-		2.5	2022-07-27	doi.org/10.1038/s41467-022-31823-1
	6IBL	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	-	2.7	2019-01-09	doi.org/10.1038/s41586-020-2419-1
	6TKO	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Arformoterol	-	Arrestin2	3.3	2020-06-17	doi.org/10.1038/s41586-020-2419-1
	7S0F	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	Gi1/β1/γ2	2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0F (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		2.96	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	chim(Gi1-CtGs)/β1/γ2	3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	7S0G (No Gprot)	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-		3.86	2021-11-17	doi.org/10.1038/s41594-021-00679-2
	2YCW	A	Amine	Adrenergic	β₁	Meleagris gallopavo	S-Carazolol	-	-	3	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCX	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.25	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCZ	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Iodocyanopindolol	-	-	3.65	2011-06-01	doi.org/10.1073/pnas.1100185108
	2YCY	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	3.15	2011-06-08	doi.org/10.1073/pnas.1100185108
	6H7N	A	Amine	Adrenergic	β₁	Meleagris gallopavo	S-Xamoterol	-	-	2.5	2018-10-17	doi.org/10.1101/436212
	6H7J	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Isoprenaline	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	6H7L	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Dobutamine	-	-	2.7	2018-10-17	doi.org/10.1126/science.aau5595
	6H7M	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Salbutamol	-	-	2.76	2018-10-17	doi.org/10.1126/science.aau5595
	6H7O	A	Amine	Adrenergic	β₁	Meleagris gallopavo	Cyanopindolol	-	-	2.8	2018-10-17	doi.org/10.1126/science.aau5595
	8S2T	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-	chim(NtGi1-Gs)/β1/γ2	3.3	2025-05-21	To be published
	8S2T (No Gprot)	A	Amine	Adrenergic	β₁	Homo sapiens	Isoprenaline	-		3.3	2025-05-21	To be published

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