psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E110	R:R:R24	17.45	No	No	5	7	6
2	R:R:E191	R:R:R24	18.61	No	No	0	3	6
3	R:R:R24	R:R:W192	7	No	Yes	5	6	4
4	R:R:H25	R:R:V36	5.54	No	No	0	6	7
5	R:R:E191	R:R:H25	17.23	No	No	0	3	6
6	R:R:S26	R:R:Y34	3.82	No	No	0	8	3
7	R:R:C27	R:R:P28	3.77	Yes	No	4	6	7
8	R:R:C27	R:R:D38	4.67	Yes	No	0	6	1
9	R:R:C27	R:R:C40	5.46	Yes	No	4	6	4
10	R:R:C27	R:R:E43	4.56	Yes	Yes	4	6	5
11	R:R:E43	R:R:P28	11	Yes	No	4	5	7
12	R:R:F300	R:R:P28	10.11	Yes	No	4	4	7
13	R:R:L29	R:R:T297	5.9	No	No	0	5	1
14	R:R:I41	R:R:V39	6.14	No	No	0	6	4
15	R:R:C40	R:R:E43	4.56	No	Yes	4	4	5
16	R:R:E43	R:R:F42	7	Yes	No	0	5	4
17	R:R:F42	R:R:V46	7.87	No	No	0	4	4
18	R:R:E43	R:R:F300	4.66	Yes	Yes	4	5	4
19	R:R:L101	R:R:T44	11.79	No	No	0	4	6
20	R:R:I47	R:R:T98	4.56	No	No	0	5	6
21	R:R:F300	R:R:I47	5.02	Yes	No	4	4	5
22	R:R:I47	R:R:W304	16.44	No	Yes	4	5	4
23	R:R:L50	R:R:S308	4.5	No	No	6	6	6
24	R:R:F311	R:R:L50	4.87	Yes	No	6	6	6
25	R:R:F311	R:R:L53	6.09	Yes	No	0	6	5
26	R:R:I54	R:R:V90	6.14	No	Yes	7	7	8
27	R:R:G91	R:R:I54	7.05	No	No	0	6	7
28	R:R:I54	R:R:S310	7.74	No	No	7	7	9
29	R:R:G57	R:R:P314	4.06	No	No	0	8	9
30	R:R:D87	R:R:N58	6.73	No	No	0	9	9
31	R:R:N58	R:R:P314	9.77	No	No	0	9	9
32	R:R:F63	R:R:L59	10.96	No	No	0	4	5
33	R:R:V61	R:R:Y317	5.05	No	Yes	0	9	9
34	R:R:I62	R:R:Y85	16.92	No	No	0	8	6
35	R:R:I62	R:R:L88	4.28	No	No	0	8	6
36	R:R:F324	R:R:V64	9.18	Yes	No	0	8	8
37	R:R:F65	R:R:S77	3.96	No	No	0	7	8
38	R:R:F65	R:R:I80	3.77	No	No	0	7	8
39	R:R:F65	R:R:Q81	21.08	No	No	0	7	6
40	R:R:L71	R:R:Y74	14.07	No	No	0	8	4
41	R:R:H72	R:R:H73	9.55	No	No	2	8	7
42	R:R:H72	R:R:Y263	5.44	No	Yes	2	8	7
43	R:R:H73	R:R:R139	5.64	No	Yes	2	7	9
44	R:R:H73	R:R:Y263	21.78	No	Yes	2	7	7
45	R:R:D138	R:R:T75	10.12	Yes	Yes	2	9	6
46	R:R:T75	R:R:Y149	4.99	Yes	Yes	2	6	8
47	R:R:T75	R:R:V153	4.76	Yes	Yes	2	6	7
48	R:R:L158	R:R:T75	4.42	No	Yes	0	7	6
49	R:R:D138	R:R:T76	5.78	Yes	Yes	2	9	8
50	R:R:R139	R:R:T76	5.17	Yes	Yes	2	9	8
51	R:R:T76	R:R:Y263	8.74	Yes	Yes	2	8	7
52	R:R:L267	R:R:T76	4.42	No	Yes	2	8	8
53	R:R:L158	R:R:Y78	5.86	No	No	0	7	4
54	R:R:C134	R:R:F79	11.17	No	No	0	6	8
55	R:R:F79	R:R:I135	3.77	No	No	0	8	9
56	R:R:I80	R:R:Y317	7.25	No	Yes	0	8	9
57	R:R:Q81	R:R:Y85	5.64	No	No	0	6	6
58	R:R:T82	R:R:W166	4.85	No	No	0	9	9
59	R:R:M83	R:R:S128	7.67	Yes	No	0	9	9
60	R:R:C131	R:R:M83	4.86	No	Yes	0	8	9
61	R:R:L132	R:R:M83	7.07	No	Yes	0	8	9
62	R:R:M83	R:R:N313	4.21	Yes	Yes	0	9	9
63	R:R:F89	R:R:Y85	4.13	No	No	0	7	6
64	R:R:D87	R:R:S310	8.83	No	No	0	9	9
65	R:R:D87	R:R:N313	4.04	No	Yes	0	9	9
66	R:R:I121	R:R:V90	6.14	Yes	Yes	0	6	8
67	R:R:L124	R:R:V90	5.96	No	Yes	0	7	8
68	R:R:S310	R:R:V90	8.08	No	Yes	7	9	8
69	R:R:I120	R:R:S93	6.19	No	No	0	5	4
70	R:R:I121	R:R:S93	4.64	Yes	No	0	6	4
71	R:R:C94	R:R:P97	3.77	No	Yes	0	7	4
72	R:R:F117	R:R:P97	11.56	No	Yes	0	5	4
73	R:R:F190	R:R:P97	8.67	Yes	Yes	0	3	4
74	R:R:F190	R:R:S100	9.25	Yes	No	0	3	4
75	R:R:I189	R:R:L101	4.28	No	No	0	4	4
76	R:R:E110	R:R:T106	5.64	No	No	0	7	4
77	R:R:E110	R:R:W192	9.81	No	Yes	5	7	4
78	R:R:S111	R:R:W192	13.59	No	Yes	0	3	4
79	R:R:C114	R:R:F190	8.38	No	Yes	0	9	3
80	R:R:C114	R:R:C193	7.28	No	No	0	9	9
81	R:R:F177	R:R:Q115	11.71	Yes	No	0	5	6
82	R:R:F117	R:R:I121	5.02	No	Yes	0	5	6
83	R:R:V123	R:R:Y119	6.31	No	Yes	0	5	6
84	R:R:S176	R:R:Y119	3.82	No	Yes	9	5	6
85	R:R:F177	R:R:Y119	6.19	Yes	Yes	9	5	6
86	R:R:H186	R:R:I121	9.28	Yes	Yes	0	2	6
87	R:R:F173	R:R:S122	7.93	Yes	No	0	6	5
88	R:R:H186	R:R:S122	5.58	Yes	No	0	2	5
89	R:R:F173	R:R:V123	3.93	Yes	No	0	6	5
90	R:R:H186	R:R:K125	13.1	Yes	Yes	1	2	6
91	R:R:K125	R:R:Q278	23.05	Yes	No	1	6	8
92	R:R:K125	R:R:Y281	8.36	Yes	Yes	1	6	6
93	R:R:A306	R:R:K125	4.82	No	Yes	1	7	6
94	R:R:S126	R:R:S169	6.52	No	No	0	6	8
95	R:R:L211	R:R:S126	6.01	Yes	No	0	7	6
96	R:R:I165	R:R:V127	4.61	No	Yes	0	6	6
97	R:R:V127	R:R:W166	13.48	Yes	No	0	6	9
98	R:R:S169	R:R:V127	4.85	No	Yes	0	8	6
99	R:R:L211	R:R:M129	4.24	Yes	No	0	7	7
100	R:R:F274	R:R:M129	4.98	Yes	No	0	9	7
101	R:R:M129	R:R:Y275	4.79	No	No	0	7	5
102	R:R:I165	R:R:W130	5.87	No	Yes	0	6	5
103	R:R:W130	R:R:Y168	6.75	Yes	No	0	5	4
104	R:R:L211	R:R:W130	4.56	Yes	Yes	0	7	5
105	R:R:P214	R:R:W130	5.4	No	Yes	0	9	5
106	R:R:A215	R:R:W130	7.78	No	Yes	0	5	5
107	R:R:L132	R:R:T271	11.79	No	No	0	8	8
108	R:R:F274	R:R:L132	7.31	Yes	No	0	9	8
109	R:R:S136	R:R:T222	9.59	No	No	3	8	7
110	R:R:S136	R:R:Y223	6.36	No	Yes	3	8	9
111	R:R:D138	R:R:R139	8.34	Yes	Yes	2	9	9
112	R:R:D138	R:R:Y149	10.34	Yes	Yes	2	9	8
113	R:R:D138	R:R:V153	4.38	Yes	Yes	2	9	7
114	R:R:A142	R:R:R139	5.53	No	Yes	0	8	9
115	R:R:T144	R:R:Y140	9.99	No	Yes	0	6	8
116	R:R:F221	R:R:Y140	6.19	No	Yes	3	4	8
117	R:R:H225	R:R:Y140	5.44	No	Yes	3	5	8
118	R:R:A142	R:R:Y149	4	No	Yes	0	8	8
119	R:R:I143	R:R:I226	7.36	No	No	0	9	9
120	R:R:I143	R:R:I229	4.42	No	No	0	9	6
121	R:R:K145	R:R:S148	12.24	No	No	0	6	5
122	R:R:N150	R:R:Y149	5.81	No	Yes	0	4	8
123	R:R:V153	R:R:Y149	13.88	Yes	Yes	2	7	8
124	R:R:P155	R:R:T154	5.25	No	No	0	3	8
125	R:R:R157	R:R:T154	5.17	No	No	0	5	8
126	R:R:I172	R:R:Y168	8.46	Yes	No	10	5	4
127	R:R:L210	R:R:Y168	5.86	No	No	10	5	4
128	R:R:F173	R:R:I172	5.02	Yes	Yes	0	6	5
129	R:R:I172	R:R:L210	4.28	Yes	No	10	5	5
130	R:R:I172	R:R:L211	5.71	Yes	Yes	0	5	7
131	R:R:F173	R:R:P183	4.33	Yes	No	0	6	4
132	R:R:F173	R:R:I207	5.02	Yes	No	0	6	6
133	R:R:F178	R:R:L174	4.87	No	No	0	5	4
134	R:R:P175	R:R:W180	5.4	No	No	0	6	6
135	R:R:F203	R:R:P175	11.56	Yes	No	0	5	6
136	R:R:F177	R:R:S176	3.96	Yes	No	9	5	5
137	R:R:P183	R:R:S176	7.13	No	No	0	4	5
138	R:R:K182	R:R:W197	23.21	No	Yes	0	3	5
139	R:R:F203	R:R:P183	5.78	Yes	No	0	5	4
140	R:R:F285	R:R:G184	4.52	Yes	No	0	5	2
141	R:R:D188	R:R:Y185	10.34	No	Yes	1	4	7
142	R:R:Y185	R:R:Y281	3.97	Yes	Yes	1	7	6
143	R:R:Y185	R:R:Y284	17.87	Yes	Yes	1	7	4
144	R:R:F285	R:R:Y185	12.38	Yes	Yes	1	5	7
145	R:R:E288	R:R:Y185	14.59	No	Yes	1	3	7
146	R:R:S299	R:R:Y185	5.09	No	Yes	1	4	7
147	R:R:H186	R:R:Y281	17.42	Yes	Yes	1	2	6
148	R:R:C193	R:R:G187	3.92	No	No	1	9	4
149	R:R:G187	R:R:W197	4.22	No	Yes	1	4	5
150	R:R:D188	R:R:W197	11.17	No	Yes	1	4	5
151	R:R:D188	R:R:S299	5.89	No	No	1	4	4
152	R:R:I189	R:R:W304	4.7	No	Yes	0	4	4
153	R:R:S196	R:R:W192	6.18	No	Yes	0	3	4
154	R:R:C193	R:R:W197	18.28	No	Yes	1	9	5
155	R:R:S289	R:R:T199	7.99	No	No	0	4	3
156	R:R:F203	R:R:F206	4.29	Yes	No	0	5	5
157	R:R:F285	R:R:T204	12.97	Yes	No	1	5	5
158	R:R:S289	R:R:T204	9.59	No	No	1	4	5
159	R:R:F206	R:R:L210	6.09	No	No	0	5	5
160	R:R:I207	R:R:Y212	4.84	No	Yes	0	6	5
161	R:R:F285	R:R:I207	3.77	Yes	No	0	5	6
162	R:R:V208	R:R:Y212	3.79	No	Yes	0	4	5
163	R:R:L211	R:R:Y212	8.21	Yes	Yes	0	7	5
164	R:R:I282	R:R:Y212	4.84	No	Yes	0	6	5
165	R:R:A216	R:R:Y275	4	No	No	0	4	5
166	R:R:V219	R:R:Y275	3.79	No	No	0	5	5
167	R:R:F221	R:R:H225	12.44	No	No	3	4	5
168	R:R:T222	R:R:Y223	4.99	No	Yes	3	7	9
169	R:R:F227	R:R:Y223	5.16	Yes	Yes	3	7	9
170	R:R:F268	R:R:Y223	12.38	No	Yes	3	5	9
171	R:R:T271	R:R:Y223	4.99	No	Yes	0	8	9
172	R:R:F224	R:R:H225	4.53	No	No	0	4	5
173	R:R:F224	R:R:K228	4.96	No	No	0	4	4
174	R:R:F227	R:R:I226	3.77	Yes	No	0	7	9
175	R:R:F227	R:R:F268	9.65	Yes	No	3	7	5
176	R:R:H233	R:R:K235	6.55	No	No	0	7	6
177	R:R:L267	R:R:Y263	5.86	No	Yes	2	8	7
178	R:R:F268	R:R:S272	3.96	No	No	0	5	5
179	R:R:I270	R:R:N313	7.08	Yes	Yes	8	8	9
180	R:R:I270	R:R:I316	4.42	Yes	No	0	8	8
181	R:R:I270	R:R:Y317	6.04	Yes	Yes	8	8	9
182	R:R:F274	R:R:Q278	9.37	Yes	No	0	9	8
183	R:R:F274	R:R:N309	12.08	Yes	No	0	9	9
184	R:R:L277	R:R:L305	4.15	No	No	0	8	7
185	R:R:L277	R:R:N309	9.61	No	No	0	8	9
186	R:R:A306	R:R:Q278	6.06	No	No	1	7	8
187	R:R:L305	R:R:P280	4.93	No	No	0	7	9
188	R:R:T303	R:R:Y281	4.99	No	Yes	0	5	6
189	R:R:E288	R:R:Y284	21.32	No	Yes	1	3	4
190	R:R:L298	R:R:Y284	7.03	No	Yes	0	4	4
191	R:R:S299	R:R:Y284	7.63	No	Yes	1	4	4
192	R:R:T302	R:R:Y284	6.24	No	Yes	0	5	4
193	R:R:F285	R:R:S289	7.93	Yes	No	1	5	4
194	R:R:L287	R:R:V292	8.94	No	No	0	4	3
195	R:R:D294	R:R:E288	12.99	No	No	0	3	3
196	R:R:N295	R:R:P296	4.89	No	No	0	3	2
197	R:R:N295	R:R:T297	4.39	No	No	0	3	1
198	R:R:L298	R:R:N295	6.87	No	No	0	4	3
199	R:R:F300	R:R:W304	16.04	Yes	Yes	4	4	4
200	R:R:T303	R:R:W304	7.28	No	Yes	0	5	4
201	R:R:I307	R:R:W304	16.44	No	Yes	0	6	4
202	R:R:F311	R:R:S308	6.61	Yes	No	6	6	6
203	R:R:C312	R:R:F311	4.19	No	Yes	0	5	6
204	R:R:N313	R:R:Y317	6.98	Yes	Yes	8	9	9
205	R:R:F324	R:R:Y317	5.16	Yes	Yes	0	8	9
206	R:R:F324	R:R:L328	7.31	Yes	No	0	8	7
207	R:R:R325	R:R:R329	6.4	No	No	0	9	5
208	R:R:E333	R:R:R330	10.47	No	No	0	4	5
209	R:R:L331	R:R:M335	4.24	No	No	0	6	4
210	R:R:I316	R:R:R269	3.76	No	No	0	8	7
211	R:R:T222	R:R:Y140	3.75	No	Yes	3	7	8
212	R:R:F52	R:R:L53	3.65	No	No	0	5	5
213	R:R:F79	R:R:L158	3.65	No	No	0	8	7
214	R:R:F227	R:R:L264	3.65	Yes	No	0	7	7
215	R:R:I135	R:R:Y223	3.63	No	Yes	0	9	9
216	R:R:D321	R:R:F324	3.58	No	Yes	0	8	8
217	R:R:G91	R:R:I55	3.53	No	No	0	6	6
218	R:R:P97	R:R:V96	3.53	Yes	No	0	4	7
219	R:R:A84	R:R:V61	3.39	No	No	0	9	9
220	R:R:A86	R:R:V127	3.39	No	Yes	0	8	6
221	R:R:A133	R:R:V218	3.39	No	No	0	7	8
222	R:R:C94	R:R:T51	3.38	No	No	0	7	6
223	R:R:C161	R:R:I165	3.27	No	No	0	6	6
224	R:R:C230	R:R:I226	3.27	No	No	0	8	9
225	R:R:S35	R:R:V37	3.23	No	No	0	5	2
226	R:R:S320	R:R:V266	3.23	No	No	0	7	8
227	R:R:S100	R:R:T106	3.2	No	No	0	4	4
228	R:R:S196	R:R:T195	3.2	No	No	0	3	4
229	R:R:T98	R:R:V48	3.17	No	No	0	6	4
230	R:R:I55	R:R:V92	3.07	No	No	0	6	4
231	R:R:I270	R:R:V266	3.07	Yes	No	0	8	8
232	R:R:M276	R:R:S272	3.07	No	No	0	4	5
233	R:R:I316	R:R:V273	3.07	No	No	0	8	7
234	R:R:I162	R:R:T82	3.04	No	No	0	8	9
235	R:R:L141	R:R:V137	2.98	No	No	0	5	6
236	R:R:L141	R:R:V153	2.98	No	Yes	0	5	7
237	R:R:L102	R:R:T44	2.95	No	No	0	4	6
238	R:R:L328	R:R:T60	2.95	No	No	0	7	6
239	R:R:D38	R:R:S35	2.94	No	No	0	1	5
240	R:R:D321	R:R:T323	2.89	No	No	0	8	7
241	R:R:I307	R:R:L50	2.85	No	No	0	6	6
242	R:R:I55	R:R:L59	2.85	No	No	0	6	5
243	R:R:I160	R:R:L164	2.85	No	No	0	3	3
244	R:R:I282	R:R:L279	2.85	No	No	0	6	6
245	R:R:H33	R:R:S35	2.79	No	No	0	4	5
246	R:R:A56	R:R:F52	2.77	No	No	0	4	5
247	R:R:H109	R:R:V108	2.77	No	No	0	6	1
248	R:R:L286	R:R:L287	2.77	No	No	0	5	4
249	R:R:A318	R:R:F324	2.77	No	Yes	0	7	8
250	R:R:C170	R:R:Y119	2.69	No	Yes	0	4	6
251	R:R:H66	R:R:I62	2.65	No	No	0	3	8
252	R:R:F203	R:R:S200	2.64	Yes	No	0	5	3
253	R:R:R262	R:R:S320	2.64	No	No	0	8	7
254	R:R:R325	R:R:S322	2.64	No	No	0	9	5
255	R:R:F177	R:R:V116	2.62	Yes	No	0	5	4
256	R:R:F190	R:R:T113	2.59	Yes	No	0	3	5
257	R:R:A133	R:R:W130	2.59	No	Yes	0	7	5
258	R:R:I163	R:R:R159	2.51	No	No	0	3	3
259	R:R:M265	R:R:R262	2.48	No	No	0	7	8
260	R:R:F63	R:R:L331	2.44	No	No	0	4	6
261	R:R:L326	R:R:R330	2.43	No	No	0	4	5
262	R:R:L70	R:R:Y74	2.34	No	No	0	5	4
263	R:R:L174	R:R:Y119	2.34	No	Yes	0	4	6
264	R:R:R262	R:R:R325	2.13	No	No	0	8	9
265	R:R:G118	R:R:G187	2.11	No	No	0	5	4
266	R:R:C27	R:R:G30	1.96	Yes	No	0	6	5
267	R:R:A68	R:R:P69	1.87	No	No	0	6	6
268	R:R:A213	R:R:P214	1.87	No	No	0	5	9
269	R:R:G181	R:R:S200	1.86	No	No	0	6	3
270	R:R:G327	R:R:V64	1.84	No	No	0	7	8
271	R:R:G107	R:R:V108	1.84	No	No	0	7	1
272	R:R:G205	R:R:V208	1.84	No	No	0	4	4
273	R:R:A201	R:R:S290	1.71	No	No	0	4	4
274	R:R:C156	R:R:T154	1.69	No	No	0	4	8
275	R:R:K145	R:R:P146	1.67	No	No	0	6	8
276	R:R:L70	R:R:P69	1.64	No	No	0	5	6
277	R:R:C156	R:R:I160	1.64	No	No	0	4	3
278	R:R:S290	R:R:V292	1.62	No	No	0	4	3
279	R:R:L71	R:R:S77	1.5	No	No	0	8	8
280	R:R:K145	R:R:T144	1.5	No	No	0	6	6
281	R:R:L95	R:R:V92	1.49	No	No	0	7	4
282	R:R:L152	R:R:V153	1.49	No	Yes	0	4	7
283	R:R:L293	R:R:V292	1.49	No	No	0	1	3
284	R:R:I163	R:R:I167	1.47	No	No	0	3	4
285	R:R:I282	R:R:I283	1.47	No	No	0	6	5
286	R:R:G32	R:R:Y34	1.45	No	No	0	4	3
287	R:R:I167	R:R:L171	1.43	No	No	0	4	4
288	R:R:H25	R:R:S26	1.39	No	No	0	6	8
289	R:R:H103	R:R:V39	1.38	No	No	0	4	4
290	R:R:L49	R:R:L53	1.38	No	No	0	4	5
291	R:R:L171	R:R:L174	1.38	No	No	0	4	4
292	R:R:L147	R:R:Q151	1.33	No	No	0	7	4
293	R:R:H109	R:R:L112	1.29	No	No	0	6	1
294	R:R:M265	R:R:R261	1.24	No	No	0	7	5
295	R:R:F31	R:R:L29	1.22	No	No	0	5	5
296	R:R:F300	R:R:L301	1.22	Yes	No	0	4	3
297	R:R:L152	R:R:R157	1.21	No	No	0	4	5
298	R:R:Q232	R:R:R231	1.17	No	No	0	4	5
299	R:R:R329	R:R:R330	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C27	4.084	5	4	6
2	R:R:E43	6.356	5	4	5
3	R:R:T75	6.0725	4	2	6
4	R:R:T76	6.0275	4	2	8
5	R:R:M83	5.9525	4	0	9
6	R:R:V90	6.58	4	7	8
7	R:R:P97	6.8825	4	0	4
8	R:R:Y119	4.27	5	9	6
9	R:R:I121	6.27	4	0	6
10	R:R:K125	12.3325	4	1	6
11	R:R:V127	6.5825	4	0	6
12	R:R:W130	5.49167	6	0	5
13	R:R:D138	7.792	5	2	9
14	R:R:R139	6.17	4	2	9
15	R:R:Y140	6.3425	4	3	8
16	R:R:Y149	7.804	5	2	8
17	R:R:V153	5.498	5	2	7
18	R:R:I172	5.8675	4	10	5
19	R:R:F173	5.246	5	0	6
20	R:R:F177	6.12	4	9	5
21	R:R:Y185	10.7067	6	1	7
22	R:R:H186	11.345	4	1	2
23	R:R:F190	7.2225	4	0	3
24	R:R:W192	9.145	4	5	4
25	R:R:W197	14.22	4	1	5
26	R:R:F203	6.0675	4	0	5
27	R:R:L211	5.746	5	0	7
28	R:R:Y212	5.42	4	0	5
29	R:R:Y223	6.25167	6	3	9
30	R:R:F227	5.5575	4	3	7
31	R:R:Y263	10.455	4	2	7
32	R:R:I270	5.1525	4	8	8
33	R:R:F274	8.435	4	0	9
34	R:R:Y281	8.685	4	1	6
35	R:R:Y284	12.018	5	1	4
36	R:R:F285	8.314	5	1	5
37	R:R:F300	7.41	5	4	4
38	R:R:W304	12.18	5	4	4
39	R:R:F311	5.44	4	6	6
40	R:R:N313	5.5775	4	8	9
41	R:R:Y317	6.096	5	8	9
42	R:R:F324	5.6	5	0	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E110	R:R:R24	13.4951	17.45	No	No	5	7	6
2	R:R:E191	R:R:R24	11.7707	18.61	No	No	0	3	6
3	R:R:C27	R:R:P28	14.1494	3.77	Yes	No	4	6	7
4	R:R:F300	R:R:P28	16.4531	10.11	Yes	No	4	4	7
5	R:R:F300	R:R:W304	44.0226	16.04	Yes	Yes	4	4	4
6	R:R:T303	R:R:W304	79.8596	7.28	No	Yes	0	5	4
7	R:R:T303	R:R:Y281	81.8293	4.99	No	Yes	0	5	6
8	R:R:H186	R:R:Y281	47.2328	17.42	Yes	Yes	1	2	6
9	R:R:H186	R:R:I121	67.3051	9.28	Yes	Yes	0	2	6
10	R:R:F117	R:R:I121	36.2664	5.02	No	Yes	0	5	6
11	R:R:F117	R:R:P97	34.726	11.56	No	Yes	0	5	4
12	R:R:F190	R:R:P97	28.5987	8.67	Yes	Yes	0	3	4
13	R:R:F190	R:R:S100	26.7107	9.25	Yes	No	0	3	4
14	R:R:S100	R:R:T106	24.8909	3.2	No	No	0	4	4
15	R:R:E110	R:R:T106	23.0575	5.64	No	No	0	7	4
16	R:R:C27	R:R:E43	14.2244	4.56	Yes	Yes	4	6	5
17	R:R:E43	R:R:F300	23.5074	4.66	Yes	Yes	4	5	4
18	R:R:C27	R:R:D38	18.9954	4.67	Yes	No	0	6	1
19	R:R:D188	R:R:W197	14.0472	11.17	No	Yes	1	4	5
20	R:R:D188	R:R:Y185	14.3198	10.34	No	Yes	1	4	7
21	R:R:Y185	R:R:Y284	16.3509	17.87	Yes	Yes	1	7	4
22	R:R:L298	R:R:Y284	13.4065	7.03	No	Yes	0	4	4
23	R:R:L298	R:R:N295	11.205	6.87	No	No	0	4	3
24	R:R:I307	R:R:W304	21.6467	16.44	No	Yes	0	6	4
25	R:R:I307	R:R:L50	19.2953	2.85	No	No	0	6	6
26	R:R:F311	R:R:L50	14.5106	4.87	Yes	No	6	6	6
27	R:R:I121	R:R:V90	49.148	6.14	Yes	Yes	0	6	8
28	R:R:I54	R:R:V90	10.5303	6.14	No	Yes	7	7	8
29	R:R:G91	R:R:I54	15.1854	7.05	No	No	0	6	7
30	R:R:S310	R:R:V90	37.7522	8.08	No	Yes	7	9	8
31	R:R:D87	R:R:S310	43.9613	8.83	No	No	0	9	9
32	R:R:G91	R:R:I55	13.3111	3.53	No	No	0	6	6
33	R:R:D87	R:R:N313	44.0703	4.04	No	Yes	0	9	9
34	R:R:N313	R:R:Y317	54.5802	6.98	Yes	Yes	8	9	9
35	R:R:I80	R:R:Y317	32.9948	7.25	No	Yes	0	8	9
36	R:R:F65	R:R:I80	30.7047	3.77	No	No	0	7	8
37	R:R:F65	R:R:Q81	14.497	21.08	No	No	0	7	6
38	R:R:Q81	R:R:Y85	12.1251	5.64	No	No	0	6	6
39	R:R:F324	R:R:Y317	19.2407	5.16	Yes	Yes	0	8	9
40	R:R:F65	R:R:S77	14.497	3.96	No	No	0	7	8
41	R:R:L71	R:R:S77	12.1251	1.5	No	No	0	8	8
42	R:R:H186	R:R:K125	12.8817	13.1	Yes	Yes	1	2	6
43	R:R:K125	R:R:Q278	61.2595	23.05	Yes	No	1	6	8
44	R:R:F274	R:R:Q278	62.2955	9.37	Yes	No	0	9	8
45	R:R:F274	R:R:L132	100	7.31	Yes	No	0	9	8
46	R:R:L132	R:R:T271	75.7225	11.79	No	No	0	8	8
47	R:R:T271	R:R:Y223	74.4684	4.99	No	Yes	0	8	9
48	R:R:I135	R:R:Y223	45.6925	3.63	No	Yes	0	9	9
49	R:R:F79	R:R:I135	44.193	3.77	No	No	0	8	9
50	R:R:F79	R:R:L158	41.0919	3.65	No	No	0	8	7
51	R:R:L158	R:R:T75	38.0248	4.42	No	Yes	0	7	6
52	R:R:D138	R:R:T75	13.8086	10.12	Yes	Yes	2	9	6
53	R:R:T75	R:R:V153	17.4414	4.76	Yes	Yes	2	6	7
54	R:R:H186	R:R:S122	42.7822	5.58	Yes	No	0	2	5
55	R:R:F173	R:R:S122	41.9916	7.93	Yes	No	0	6	5
56	R:R:F173	R:R:I172	41.4122	5.02	Yes	Yes	0	6	5
57	R:R:I172	R:R:Y168	10.0804	8.46	Yes	No	10	5	4
58	R:R:I165	R:R:W130	20.2358	5.87	No	Yes	0	6	5
59	R:R:I165	R:R:V127	14.5515	4.61	No	Yes	0	6	6
60	R:R:V127	R:R:W166	15.1854	13.48	Yes	No	0	6	9
61	R:R:T82	R:R:W166	10.135	4.85	No	No	0	9	9
62	R:R:I172	R:R:L211	36.6753	5.71	Yes	Yes	0	5	7
63	R:R:L211	R:R:W130	28.7146	4.56	Yes	Yes	0	7	5
64	R:R:L211	R:R:S126	15.2604	6.01	Yes	No	0	7	6
65	R:R:S126	R:R:S169	13.0248	6.52	No	No	0	6	8
66	R:R:S169	R:R:V127	10.837	4.85	No	Yes	0	8	6
67	R:R:M83	R:R:N313	61.3686	4.21	Yes	Yes	0	9	9
68	R:R:F173	R:R:V123	24.3389	3.93	Yes	No	0	6	5
69	R:R:V123	R:R:Y119	22.3419	6.31	No	Yes	0	5	6
70	R:R:F173	R:R:P183	19.9019	4.33	Yes	No	0	6	4
71	R:R:F274	R:R:M129	57.3337	4.98	Yes	No	0	9	7
72	R:R:T222	R:R:Y223	18.123	4.99	No	Yes	3	7	9
73	R:R:T222	R:R:Y140	16.4327	3.75	No	Yes	3	7	8
74	R:R:F227	R:R:Y223	10.7961	5.16	Yes	Yes	3	7	9
75	R:R:L152	R:R:V153	12.8749	1.49	No	Yes	0	4	7
76	R:R:L152	R:R:R157	11.0755	1.21	No	No	0	4	5
77	R:R:F285	R:R:Y185	24.0526	12.38	Yes	Yes	1	5	7
78	R:R:F285	R:R:I207	21.2923	3.77	Yes	No	0	5	6
79	R:R:L174	R:R:Y119	12.7113	2.34	No	Yes	0	4	6
80	R:R:F203	R:R:P183	10.3394	5.78	Yes	No	0	5	4
81	R:R:I207	R:R:Y212	19.5543	4.84	No	Yes	0	6	5
82	R:R:I270	R:R:N313	32.7017	7.08	Yes	Yes	8	8	9
83	R:R:I270	R:R:V266	26.1246	3.07	Yes	No	0	8	8
84	R:R:S320	R:R:V266	23.8073	3.23	No	No	0	7	8
85	R:R:R262	R:R:S320	21.5853	2.64	No	No	0	8	7
86	R:R:R262	R:R:R325	14.5106	2.13	No	No	0	8	9
87	R:R:D38	R:R:S35	14.2653	2.94	No	No	0	1	5
88	R:R:Y185	R:R:Y281	39.7833	3.97	Yes	Yes	1	7	6
89	R:R:K125	R:R:Y281	49.3661	8.36	Yes	Yes	1	6	6
90	R:R:L132	R:R:M83	63.5973	7.07	No	Yes	0	8	9
91	R:R:L211	R:R:M129	53.9531	4.24	Yes	No	0	7	7
92	R:R:L211	R:R:Y212	19.3089	8.21	Yes	Yes	0	7	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6LI1

PDB Summary
PDB	6LI1
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR52
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.9
Date	2020-02-26
D.O.I.	doi.org/10.1038/s41586-020-2019-0

Net Summary
I_min	3.77
Number of Linked Nodes	269
Number of Links	299
Number of Hubs	42
Number of Links mediated by Hubs	155
Number of Communities	10
Number of Nodes involved in Communities	59
Number of Links involved in Communities	76

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	42534
Length Of Smallest Path	3
Average Path Length	12.8101
Length of Longest Path	31
Minimum Path Strength	1.35
Average Path Strength	6.96385
Maximum Path Strength	20.745
Minimum Path Correlation	0.7
Average Path Correlation	0.934354
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	55.5868
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	46.1648
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• FMN binding • binding • nucleoside phosphate binding • ion binding • anion binding • nucleotide binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • electron transfer activity • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • behavior • multicellular organismal process
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • behavior • multicellular organismal process • locomotory behavior • response to light stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • phototransduction • detection of light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Flavoproteins
SCOP2	Family Identifier	• Flavoproteins
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y2T5
Sequence	>6LI1_Chain_R R H S C P L G F G H Y S V V D V C I F E T V V I V L L T F L I I A G N L T V I F V F H C A P L L H H Y T T S Y F I Q T M A Y A D L F V G V S C L V P T L S L L H Y S T G V H E S L T C Q V F G Y I I S V L K S V S M W C L A C I S V D R Y L A I T K P L S Y N Q L V T P C R L R I C I I L I W I Y S C L I F L P S F F G W G K P G Y H G D I F E W C A T S W L T S A Y F T G F I V C L L Y A P A A F V V C F T Y F H I F K I C R Q H T K E R R Y L M V L F R I T S V F Y M L Q L P Y I I Y F L L E S S R V L D N P T L S F L T T W L A I S N S F C N P V I Y A L S D S T F R L G L R R L S E T M C T S C M C Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HMP	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17	Gs/β1/γ2	2.77	2023-06-21	doi.org/10.1002/mco2.260
	8HMP (No Gprot)	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17		2.77	2023-06-21	doi.org/10.1002/mco2.260
	6LI0	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17	-	2.2	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI1	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.9	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI2	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.8	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI3	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	Gs/β1/γ2	3.32	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI3 (No Gprot)	A	Orphan	Orphan	GPR52	Homo sapiens	-	-		3.32	2020-02-26	doi.org/10.1038/s41586-020-2019-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LI1.zip

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You can also read or download a guide explaining the meaning of all files and numerical data.