psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:S26	R:R:Y34	5.09	No	Yes	1	8	3
2	R:R:P296	R:R:S26	7.13	No	No	0	2	8
3	R:R:S26	W:W:?1	3.94	No	Yes	1	8	0
4	R:R:C27	R:R:P28	3.77	Yes	No	0	6	7
5	R:R:C27	R:R:G30	3.92	Yes	No	0	6	5
6	R:R:C27	R:R:F31	6.98	Yes	Yes	1	6	5
7	R:R:C27	R:R:C40	7.28	Yes	Yes	1	6	4
8	R:R:E43	R:R:P28	4.72	Yes	No	0	5	7
9	R:R:F31	R:R:L29	4.87	Yes	No	0	5	5
10	R:R:F42	R:R:L29	6.09	No	No	0	4	5
11	R:R:F31	R:R:V39	5.24	Yes	No	0	5	4
12	R:R:C40	R:R:F31	5.59	Yes	Yes	1	4	5
13	R:R:C40	R:R:Y34	5.38	Yes	Yes	1	4	3
14	R:R:E43	R:R:Y34	6.73	Yes	Yes	1	5	3
15	R:R:Y34	W:W:?1	14.77	Yes	Yes	1	3	0
16	R:R:D38	R:R:E191	5.2	No	No	1	1	3
17	R:R:D38	W:W:?1	6.41	No	Yes	1	1	0
18	R:R:C40	R:R:E43	4.56	Yes	Yes	1	4	5
19	R:R:E43	R:R:F300	11.66	Yes	Yes	1	5	4
20	R:R:V46	R:R:W304	4.9	No	No	0	4	4
21	R:R:I47	R:R:T98	4.56	No	No	0	5	6
22	R:R:F300	R:R:I47	5.02	Yes	No	1	4	5
23	R:R:I47	W:W:?1	6	No	Yes	1	5	0
24	R:R:L50	R:R:W304	10.25	No	No	0	6	4
25	R:R:L50	R:R:S308	4.5	No	No	5	6	6
26	R:R:F311	R:R:L50	6.09	Yes	No	5	6	6
27	R:R:L95	R:R:T51	7.37	Yes	No	0	7	6
28	R:R:F311	R:R:L53	9.74	Yes	No	0	6	5
29	R:R:I54	R:R:N58	4.25	Yes	Yes	0	7	9
30	R:R:G91	R:R:I54	3.53	No	Yes	0	6	7
31	R:R:I54	R:R:S310	4.64	Yes	No	0	7	9
32	R:R:F311	R:R:I54	5.02	Yes	Yes	0	6	7
33	R:R:G91	R:R:I55	3.53	No	No	0	6	6
34	R:R:I55	R:R:V92	4.61	No	No	0	6	4
35	R:R:I55	R:R:L95	5.71	No	Yes	0	6	7
36	R:R:G57	R:R:T60	3.64	No	No	0	8	6
37	R:R:G57	R:R:P314	4.06	No	No	0	8	9
38	R:R:D87	R:R:N58	8.08	No	Yes	0	9	9
39	R:R:N58	R:R:P314	4.89	Yes	No	0	9	9
40	R:R:F63	R:R:L59	10.96	No	No	0	4	5
41	R:R:V61	R:R:Y317	6.31	No	No	0	9	9
42	R:R:F65	R:R:I62	5.02	No	No	0	7	8
43	R:R:I62	R:R:Y85	7.25	No	No	0	8	6
44	R:R:F65	R:R:Q81	11.71	No	No	0	7	6
45	R:R:L71	R:R:Y263	14.07	No	Yes	0	8	7
46	R:R:H72	R:R:Y74	4.36	No	No	0	8	4
47	R:R:H72	R:R:S77	13.95	No	No	0	8	8
48	R:R:H73	R:R:Y263	7.62	No	Yes	0	7	7
49	R:R:P155	R:R:Y74	5.56	No	No	0	3	4
50	R:R:D138	R:R:T75	8.67	No	No	6	9	6
51	R:R:T75	R:R:Y149	4.99	No	Yes	6	6	8
52	R:R:I135	R:R:T76	6.08	No	No	0	9	8
53	R:R:Q81	R:R:Y78	4.51	No	No	0	6	4
54	R:R:L158	R:R:Y78	8.21	No	No	0	7	4
55	R:R:R159	R:R:Y78	7.2	No	No	0	3	4
56	R:R:C134	R:R:F79	11.17	No	Yes	7	6	8
57	R:R:F79	R:R:I135	5.02	Yes	No	0	8	9
58	R:R:C161	R:R:F79	4.19	No	Yes	7	6	8
59	R:R:F79	R:R:I162	6.28	Yes	No	0	8	8
60	R:R:I80	R:R:N313	4.25	No	No	0	8	9
61	R:R:Q81	R:R:Y85	4.51	No	No	0	6	6
62	R:R:I162	R:R:T82	6.08	No	No	0	8	9
63	R:R:T82	R:R:W166	3.64	No	No	0	9	9
64	R:R:L132	R:R:M83	7.07	No	No	0	8	9
65	R:R:M83	R:R:N313	9.82	No	No	0	9	9
66	R:R:D87	R:R:S310	11.78	No	No	0	9	9
67	R:R:G91	R:R:V90	3.68	No	No	0	6	8
68	R:R:L124	R:R:V90	4.47	No	No	0	7	8
69	R:R:C94	R:R:I121	4.91	No	Yes	0	7	6
70	R:R:C94	W:W:?1	4.17	No	Yes	0	7	0
71	R:R:P97	R:R:V96	3.53	No	No	0	4	7
72	R:R:E110	R:R:W192	5.45	No	Yes	0	7	4
73	R:R:Q115	R:R:S111	5.78	No	No	3	6	3
74	R:R:S111	R:R:W192	11.12	No	Yes	3	3	4
75	R:R:C114	R:R:F190	11.17	No	Yes	0	9	3
76	R:R:C114	R:R:C193	7.28	No	No	0	9	9
77	R:R:Q115	R:R:W192	5.48	No	Yes	3	6	4
78	R:R:Q115	R:R:W197	13.14	No	Yes	3	6	5
79	R:R:F117	R:R:G118	4.52	Yes	No	0	5	5
80	R:R:F117	R:R:I121	8.79	Yes	Yes	0	5	6
81	R:R:F117	R:R:I189	8.79	Yes	Yes	1	5	4
82	R:R:F117	R:R:F190	8.57	Yes	Yes	1	5	3
83	R:R:F117	W:W:?1	5.76	Yes	Yes	1	5	0
84	R:R:V123	R:R:Y119	8.83	No	Yes	0	5	6
85	R:R:L174	R:R:Y119	9.38	No	Yes	0	4	6
86	R:R:F177	R:R:Y119	15.47	No	Yes	0	5	6
87	R:R:H186	R:R:I121	11.93	Yes	Yes	0	2	6
88	R:R:F173	R:R:S122	15.85	Yes	No	0	6	5
89	R:R:S169	R:R:V123	4.85	No	No	0	8	5
90	R:R:F173	R:R:V123	5.24	Yes	No	0	6	5
91	R:R:K125	R:R:S128	6.12	Yes	No	0	6	9
92	R:R:K125	R:R:W278	6.96	Yes	Yes	2	6	8
93	R:R:K125	R:R:N309	8.39	Yes	Yes	2	6	9
94	R:R:K125	R:R:S310	6.12	Yes	No	0	6	9
95	R:R:F173	R:R:S126	3.96	Yes	No	4	6	6
96	R:R:L211	R:R:S126	7.51	Yes	No	4	7	6
97	R:R:V127	R:R:W166	14.71	No	No	0	6	9
98	R:R:M129	R:R:Y212	5.99	No	Yes	0	7	5
99	R:R:A215	R:R:M129	4.83	No	No	2	5	7
100	R:R:M129	R:R:Y275	5.99	No	Yes	2	7	5
101	R:R:I165	R:R:W130	3.52	No	Yes	0	6	5
102	R:R:W130	R:R:Y168	4.82	Yes	No	0	5	4
103	R:R:P214	R:R:W130	4.05	No	Yes	0	9	5
104	R:R:F274	R:R:L132	8.53	Yes	No	0	9	8
105	R:R:C134	R:R:C161	3.64	No	No	7	6	6
106	R:R:C134	R:R:I165	4.91	No	No	0	6	6
107	R:R:S136	R:R:V219	6.46	No	No	2	8	5
108	R:R:S136	R:R:T222	6.4	No	No	2	8	7
109	R:R:S136	R:R:Y223	3.82	No	Yes	2	8	9
110	R:R:D138	R:R:R139	3.57	No	No	0	9	9
111	R:R:D138	R:R:Y149	9.2	No	Yes	6	9	8
112	R:R:L141	R:R:Y140	3.52	No	Yes	0	5	8
113	R:R:T144	R:R:Y140	18.73	No	Yes	0	6	8
114	R:R:T222	R:R:Y140	3.75	No	Yes	0	7	8
115	R:R:H225	R:R:Y140	7.62	Yes	Yes	0	5	8
116	R:R:A142	R:R:Y149	4	No	Yes	0	8	8
117	R:R:I143	R:R:I229	4.42	No	No	0	9	6
118	R:R:N150	R:R:Y149	5.81	No	Yes	0	4	8
119	R:R:V153	R:R:Y149	7.57	No	Yes	0	7	8
120	R:R:R157	R:R:T154	6.47	No	No	0	5	8
121	R:R:I172	R:R:Y168	12.09	Yes	No	0	5	4
122	R:R:F173	R:R:I172	3.77	Yes	Yes	4	6	5
123	R:R:I172	R:R:L211	8.56	Yes	Yes	4	5	7
124	R:R:F173	R:R:V208	3.93	Yes	No	0	6	4
125	R:R:F173	R:R:L211	7.31	Yes	Yes	4	6	7
126	R:R:P175	R:R:W180	5.4	No	No	0	6	6
127	R:R:F177	R:R:S176	3.96	No	No	0	5	5
128	R:R:P183	R:R:S176	8.91	No	No	0	4	5
129	R:R:W180	R:R:Y202	7.72	No	No	8	6	6
130	R:R:F203	R:R:W180	23.05	No	No	8	5	6
131	R:R:G181	R:R:S200	3.71	No	No	0	6	3
132	R:R:D188	R:R:K182	4.15	Yes	No	0	4	3
133	R:R:K182	R:R:W197	19.73	No	Yes	0	3	5
134	R:R:P183	R:R:W197	4.05	No	Yes	0	4	5
135	R:R:D188	R:R:Y185	4.6	Yes	Yes	0	4	7
136	R:R:T199	R:R:Y185	8.74	No	Yes	1	3	7
137	R:R:Y185	R:R:Y281	7.94	Yes	Yes	1	7	6
138	R:R:F285	R:R:Y185	9.28	Yes	Yes	0	5	7
139	R:R:E288	R:R:Y185	14.59	Yes	Yes	1	3	7
140	R:R:H186	R:R:Y281	5.44	Yes	Yes	1	2	6
141	R:R:H186	R:R:T303	6.85	Yes	No	1	2	5
142	R:R:H186	R:R:I307	5.3	Yes	No	0	2	6
143	R:R:A194	R:R:D188	4.63	No	Yes	0	4	4
144	R:R:D188	W:W:?1	5.7	Yes	Yes	0	4	0
145	R:R:F190	R:R:I189	12.56	Yes	Yes	1	3	4
146	R:R:I189	W:W:?1	11.24	Yes	Yes	1	4	0
147	R:R:E191	W:W:?1	5.57	No	Yes	1	3	0
148	R:R:C193	R:R:W192	3.92	No	Yes	3	9	4
149	R:R:S196	R:R:W192	14.83	No	Yes	0	3	4
150	R:R:W192	R:R:W197	6.56	Yes	Yes	3	4	5
151	R:R:C193	R:R:W197	5.22	No	Yes	3	9	5
152	R:R:E288	R:R:T199	4.23	Yes	No	1	3	3
153	R:R:S200	R:R:T204	7.99	No	No	0	3	5
154	R:R:F203	R:R:Y202	5.16	No	No	8	5	6
155	R:R:F203	R:R:I207	5.02	No	No	0	5	6
156	R:R:F285	R:R:T204	3.89	Yes	No	0	5	5
157	R:R:C209	R:R:G205	3.92	No	No	0	4	4
158	R:R:F285	R:R:V208	5.24	Yes	No	0	5	4
159	R:R:C209	R:R:L286	4.76	No	No	0	4	5
160	R:R:L211	R:R:Y212	7.03	Yes	Yes	0	7	5
161	R:R:W278	R:R:Y212	8.68	Yes	Yes	0	8	5
162	R:R:I282	R:R:Y212	8.46	No	Yes	0	6	5
163	R:R:A215	R:R:Y275	4	No	Yes	2	5	5
164	R:R:F217	R:R:V218	3.93	No	No	0	6	8
165	R:R:V219	R:R:Y223	3.79	No	Yes	2	5	9
166	R:R:V219	R:R:Y275	11.36	No	Yes	2	5	5
167	R:R:F221	R:R:H225	13.58	No	Yes	0	4	5
168	R:R:T222	R:R:Y223	3.75	No	Yes	2	7	9
169	R:R:F268	R:R:Y223	4.13	Yes	Yes	0	5	9
170	R:R:T271	R:R:Y223	8.74	No	Yes	0	8	9
171	R:R:F224	R:R:H225	5.66	No	Yes	0	4	5
172	R:R:H225	R:R:K228	3.93	Yes	No	0	5	4
173	R:R:F268	R:R:I226	5.02	Yes	No	0	5	9
174	R:R:F227	R:R:F268	6.43	No	Yes	0	7	5
175	R:R:D239	R:R:K235	6.91	No	No	0	4	6
176	R:R:I237	R:R:R241	3.76	No	No	0	7	4
177	R:R:N238	R:R:R241	12.05	No	No	0	3	4
178	R:R:F244	R:R:R243	12.83	No	No	0	3	4
179	R:R:R262	R:R:Y263	5.14	No	Yes	0	8	7
180	R:R:M265	R:R:R269	9.93	No	No	0	7	7
181	R:R:I316	R:R:L267	5.71	No	No	0	8	8
182	R:R:I270	R:R:I316	5.89	No	No	0	8	8
183	R:R:F274	R:R:Y275	7.22	Yes	Yes	2	9	5
184	R:R:F274	R:R:W278	10.02	Yes	Yes	2	9	8
185	R:R:F274	R:R:N309	9.67	Yes	Yes	2	9	9
186	R:R:C312	R:R:F274	4.19	No	Yes	0	5	9
187	R:R:L277	R:R:L305	5.54	No	No	0	8	7
188	R:R:L277	R:R:N309	4.12	No	Yes	0	8	9
189	R:R:N309	R:R:W278	14.69	Yes	Yes	2	9	8
190	R:R:T303	R:R:Y281	7.49	No	Yes	1	5	6
191	R:R:A306	R:R:Y281	4	No	Yes	0	7	6
192	R:R:E288	R:R:Y284	4.49	Yes	Yes	0	3	4
193	R:R:S299	R:R:Y284	3.82	No	Yes	0	4	4
194	R:R:T302	R:R:Y284	6.24	No	Yes	0	5	4
195	R:R:L287	R:R:R291	3.64	No	No	0	4	1
196	R:R:D294	R:R:E288	9.09	No	Yes	0	3	3
197	R:R:R291	R:R:V292	5.23	No	No	0	1	3
198	R:R:L293	R:R:R291	12.15	No	No	0	1	1
199	R:R:N295	R:R:P296	6.52	No	No	0	3	2
200	R:R:N295	R:R:T297	7.31	No	No	0	3	1
201	R:R:L298	R:R:N295	15.1	No	No	0	4	3
202	R:R:F300	W:W:?1	10.23	Yes	Yes	1	4	0
203	R:R:T303	W:W:?1	3.87	No	Yes	1	5	0
204	R:R:I307	W:W:?1	4.5	No	Yes	0	6	0
205	R:R:F311	R:R:S308	3.96	Yes	No	5	6	6
206	R:R:I316	R:R:Y317	3.63	No	No	0	8	9
207	R:R:N321	R:R:S320	8.94	No	No	0	8	7
208	R:R:P155	R:R:T154	3.5	No	No	0	3	8
209	R:R:P280	R:R:T302	3.5	No	No	0	9	5
210	R:R:F65	R:R:H66	3.39	No	No	0	7	3
211	R:R:I189	R:R:P97	3.39	Yes	No	0	4	4
212	R:R:C131	R:R:T82	3.38	No	No	0	8	9
213	R:R:C156	R:R:T154	3.38	No	No	0	4	8
214	R:R:A84	R:R:I62	3.25	No	No	0	9	8
215	R:R:S35	R:R:V36	3.23	No	No	0	5	7
216	R:R:S318	R:R:V315	3.23	No	No	0	7	7
217	R:R:V37	R:R:V39	3.21	No	No	0	2	4
218	R:R:V61	R:R:V64	3.21	No	No	0	9	8
219	R:R:V137	R:R:V218	3.21	No	No	0	6	8
220	R:R:F227	R:R:R231	3.21	No	No	0	7	5
221	R:R:F268	R:R:R269	3.21	Yes	No	0	5	7
222	R:R:S196	R:R:T195	3.2	No	No	0	3	4
223	R:R:T98	R:R:V48	3.17	No	No	0	6	4
224	R:R:I120	R:R:S93	3.1	No	No	0	5	4
225	R:R:I121	R:R:S93	3.1	Yes	No	0	6	4
226	R:R:K145	R:R:S148	3.06	No	No	0	6	5
227	R:R:F117	R:R:G187	3.01	Yes	No	0	5	4
228	R:R:K145	R:R:T144	3	No	No	0	6	6
229	R:R:L319	R:R:S318	3	No	No	0	5	7
230	R:R:L112	R:R:V116	2.98	No	No	0	1	4
231	R:R:L102	R:R:T44	2.95	No	Yes	0	4	6
232	R:R:L158	R:R:T75	2.95	No	No	0	7	6
233	R:R:I163	R:R:I167	2.94	No	No	0	3	4
234	R:R:I172	R:R:I207	2.94	Yes	No	0	5	6
235	R:R:N238	R:R:T234	2.92	No	No	0	3	5
236	R:R:I80	R:R:L267	2.85	No	No	0	8	8
237	R:R:I162	R:R:L158	2.85	No	No	0	8	7
238	R:R:I167	R:R:L171	2.85	No	No	0	4	4
239	R:R:I283	R:R:L287	2.85	No	No	0	5	4
240	R:R:L279	R:R:M276	2.83	No	No	0	6	4
241	R:R:L88	R:R:N58	2.75	No	Yes	0	6	9
242	R:R:C170	R:R:Y119	2.69	No	Yes	0	4	6
243	R:R:A216	R:R:Y275	2.67	No	Yes	0	4	5
244	R:R:A264	R:R:Y263	2.67	No	Yes	0	7	7
245	R:R:H233	R:R:I229	2.65	No	No	0	7	6
246	R:R:F177	R:R:V116	2.62	No	No	0	5	4
247	R:R:A86	R:R:W166	2.59	No	No	0	8	9
248	R:R:A133	R:R:W130	2.59	No	Yes	0	7	5
249	R:R:H109	R:R:L112	2.57	No	No	0	6	1
250	R:R:S320	R:R:Y263	2.54	No	Yes	0	7	7
251	R:R:T106	R:R:Y104	2.5	Yes	No	0	4	4
252	R:R:F89	R:R:L124	2.44	No	No	0	7	7
253	R:R:F190	R:R:L101	2.44	Yes	No	0	3	4
254	R:R:L293	R:R:Y284	2.34	No	Yes	0	1	4
255	R:R:F217	R:R:F221	2.14	No	No	0	6	4
256	R:R:F244	R:R:R240	2.14	No	No	0	3	3
257	R:R:A56	R:R:G57	1.95	No	No	0	4	8
258	R:R:A68	R:R:P69	1.87	No	No	0	6	6
259	R:R:A213	R:R:P214	1.87	No	No	0	5	9
260	R:R:G205	R:R:V208	1.84	No	No	0	4	4
261	R:R:G107	R:R:T106	1.82	No	Yes	0	7	4
262	R:R:C230	R:R:T234	1.69	No	No	0	8	5
263	R:R:K145	R:R:P146	1.67	No	No	0	6	8
264	R:R:L279	R:R:P280	1.64	No	No	0	6	9
265	R:R:S105	R:R:V36	1.62	No	No	0	4	7
266	R:R:S100	R:R:V96	1.62	No	No	0	4	7
267	R:R:S320	R:R:V266	1.62	No	No	0	7	8
268	R:R:S272	R:R:V273	1.62	No	No	0	5	7
269	R:R:S290	R:R:T199	1.6	No	No	0	4	3
270	R:R:T44	R:R:V45	1.59	Yes	No	0	6	6
271	R:R:T106	R:R:V108	1.59	Yes	No	0	4	1
272	R:R:A68	R:R:L70	1.58	No	No	0	6	5
273	R:R:T44	W:W:?1	1.55	Yes	Yes	0	6	0
274	R:R:I270	R:R:V266	1.54	No	No	0	8	8
275	R:R:I270	R:R:V315	1.54	No	No	0	8	7
276	R:R:H72	R:R:P69	1.53	No	No	0	8	6
277	R:R:M276	R:R:S272	1.53	No	No	0	4	5
278	R:R:I41	R:R:T44	1.52	No	Yes	0	6	6
279	R:R:I143	R:R:T144	1.52	No	No	0	9	6
280	R:R:F285	R:R:G184	1.51	Yes	No	0	5	2
281	R:R:L152	R:R:V153	1.49	No	No	0	4	7
282	R:R:Q151	R:R:S148	1.44	No	No	0	4	5
283	R:R:F244	R:R:P245	1.44	No	No	0	3	3
284	R:R:I160	R:R:L164	1.43	No	No	0	3	3
285	R:R:I207	R:R:L210	1.43	No	No	0	6	5
286	R:R:E110	R:R:T106	1.41	No	Yes	0	7	4
287	R:R:L59	R:R:L88	1.38	No	No	0	5	6
288	R:R:L95	R:R:L99	1.38	Yes	No	0	7	6
289	R:R:L171	R:R:L174	1.38	No	No	0	4	4
290	R:R:H33	R:R:T195	1.37	No	No	0	4	4
291	R:R:H109	R:R:T113	1.37	No	No	0	6	5
292	R:R:I229	R:R:Q232	1.37	No	No	0	6	4
293	R:R:E236	R:R:H233	1.23	No	No	0	5	7
294	R:R:F52	R:R:L95	1.22	No	Yes	0	5	7
295	R:R:F178	R:R:L174	1.22	No	No	0	5	4
296	R:R:F300	R:R:L301	1.22	Yes	No	0	4	3
297	R:R:H103	R:R:Y104	1.09	No	No	0	4	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:C27	5.4875	4	1	6
2	R:R:F31	5.67	4	1	5
3	R:R:Y34	7.9925	4	1	3
4	R:R:C40	5.7025	4	1	4
5	R:R:E43	6.9175	4	1	5
6	R:R:T44	1.9025	4	0	6
7	R:R:I54	4.36	4	0	7
8	R:R:N58	4.9925	4	0	9
9	R:R:F79	6.665	4	7	8
10	R:R:L95	3.92	4	0	7
11	R:R:T106	1.83	4	0	4
12	R:R:F117	6.57333	6	1	5
13	R:R:Y119	9.0925	4	0	6
14	R:R:I121	7.1825	4	0	6
15	R:R:K125	6.8975	4	2	6
16	R:R:W130	3.745	4	0	5
17	R:R:Y140	8.405	4	0	8
18	R:R:Y149	6.314	5	6	8
19	R:R:I172	6.84	4	4	5
20	R:R:F173	6.67667	6	4	6
21	R:R:Y185	9.03	5	1	7
22	R:R:H186	7.38	4	1	2
23	R:R:D188	4.77	4	0	4
24	R:R:I189	8.995	4	1	4
25	R:R:F190	8.685	4	1	3
26	R:R:W192	7.89333	6	3	4
27	R:R:W197	9.74	5	3	5
28	R:R:L211	7.6025	4	4	7
29	R:R:Y212	7.54	4	0	5
30	R:R:Y223	4.846	5	2	9
31	R:R:H225	7.6975	4	0	5
32	R:R:Y263	6.408	5	0	7
33	R:R:F268	4.6975	4	0	5
34	R:R:F274	7.926	5	2	9
35	R:R:Y275	6.248	5	2	5
36	R:R:W278	10.0875	4	2	8
37	R:R:Y281	6.2175	4	1	6
38	R:R:Y284	4.2225	4	0	4
39	R:R:F285	4.98	4	0	5
40	R:R:E288	8.1	4	1	3
41	R:R:F300	7.0325	4	1	4
42	R:R:N309	9.2175	4	2	9
43	R:R:F311	6.2025	4	5	6
44	W:W:?1	6.43923	13	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:C40	R:R:Y34	10.4511	5.38	Yes	Yes	1	4	3
2	R:R:D188	W:W:?1	48.6907	5.7	Yes	Yes	0	4	0
3	R:R:D188	R:R:Y185	60.9032	4.6	Yes	Yes	0	4	7
4	R:R:F285	R:R:Y185	77.5659	9.28	Yes	Yes	0	5	7
5	R:R:F285	R:R:V208	79.7676	5.24	Yes	No	0	5	4
6	R:R:F173	R:R:V208	81.3979	3.93	Yes	No	0	6	4
7	R:R:F173	R:R:L211	75.3267	7.31	Yes	Yes	4	6	7
8	R:R:L211	R:R:Y212	100	7.03	Yes	Yes	0	7	5
9	R:R:W278	R:R:Y212	54.3308	8.68	Yes	Yes	0	8	5
10	R:R:K125	R:R:W278	44.8869	6.96	Yes	Yes	2	6	8
11	R:R:K125	R:R:S310	55.7409	6.12	Yes	No	0	6	9
12	R:R:I54	R:R:S310	40.0103	4.64	Yes	No	0	7	9
13	R:R:F311	R:R:I54	10.17	5.02	Yes	Yes	0	6	7
14	R:R:G91	R:R:I55	10.17	3.53	No	No	0	6	6
15	R:R:G91	R:R:I54	16.7658	3.53	No	Yes	0	6	7
16	R:R:I54	R:R:N58	13.4914	4.25	Yes	Yes	0	7	9
17	R:R:D87	R:R:N58	12.8917	8.08	No	Yes	0	9	9
18	R:R:D87	R:R:S310	14.4517	11.78	No	No	0	9	9
19	R:R:N58	R:R:P314	13.1869	4.89	Yes	No	0	9	9
20	R:R:F274	R:R:W278	32.918	10.02	Yes	Yes	2	9	8
21	R:R:F274	R:R:L132	30.8849	8.53	Yes	No	0	9	8
22	R:R:L132	R:R:M83	29.5077	7.07	No	No	0	8	9
23	R:R:M83	R:R:N313	28.121	9.82	No	No	0	9	9
24	R:R:I80	R:R:N313	26.7251	4.25	No	No	0	8	9
25	R:R:I80	R:R:L267	25.3197	2.85	No	No	0	8	8
26	R:R:I316	R:R:L267	23.905	5.71	No	No	0	8	8
27	R:R:Q81	R:R:Y78	10.9008	4.51	No	No	0	6	4
28	R:R:L158	R:R:Y78	13.5335	8.21	No	No	0	7	4
29	R:R:I162	R:R:L158	24.9028	2.85	No	No	0	8	7
30	R:R:F79	R:R:I162	32.0701	6.28	Yes	No	0	8	8
31	R:R:C134	R:R:F79	35.3961	11.17	No	Yes	7	6	8
32	R:R:C134	R:R:I165	37.7852	4.91	No	No	0	6	6
33	R:R:I165	R:R:W130	38.9001	3.52	No	Yes	0	6	5
34	R:R:W130	R:R:Y168	43.2613	4.82	Yes	No	0	5	4
35	R:R:I172	R:R:Y168	44.3294	12.09	Yes	No	0	5	4
36	R:R:F173	R:R:I172	26.9687	3.77	Yes	Yes	4	6	5
37	R:R:S320	R:R:V266	10.7509	1.62	No	No	0	7	8
38	R:R:I270	R:R:V266	12.25	1.54	No	No	0	8	8
39	R:R:I270	R:R:I316	18.1524	5.89	No	No	0	8	8
40	R:R:L158	R:R:T75	10.8868	2.95	No	No	0	7	6
41	R:R:E110	R:R:W192	12.3624	5.45	No	Yes	0	7	4
42	R:R:W192	R:R:W197	21.5862	6.56	Yes	Yes	3	4	5
43	R:R:K182	R:R:W197	21.3613	19.73	No	Yes	0	3	5
44	R:R:D188	R:R:K182	22.3544	4.15	Yes	No	0	4	3
45	R:R:F173	R:R:V123	29.0439	5.24	Yes	No	0	6	5
46	R:R:P183	R:R:W197	18.2274	4.05	No	Yes	0	4	5
47	R:R:P183	R:R:S176	18.5928	8.91	No	No	0	4	5
48	R:R:F177	R:R:S176	18.9863	3.96	No	No	0	5	5
49	R:R:F177	R:R:Y119	21.4222	15.47	No	Yes	0	5	6
50	R:R:V123	R:R:Y119	27.0296	8.83	No	Yes	0	5	6
51	R:R:M129	R:R:Y212	45.8425	5.99	No	Yes	0	7	5
52	R:R:M129	R:R:Y275	44.1514	5.99	No	Yes	2	7	5
53	R:R:S136	R:R:V219	28.1023	6.46	No	No	2	8	5
54	R:R:V219	R:R:Y275	66.6932	11.36	No	Yes	2	5	5
55	R:R:S136	R:R:T222	26.8562	6.4	No	No	2	8	7
56	R:R:V219	R:R:Y223	37.4807	3.79	No	Yes	2	5	9
57	R:R:T222	R:R:Y223	27.5121	3.75	No	Yes	2	7	9
58	R:R:T222	R:R:Y140	51.7403	3.75	No	Yes	0	7	8
59	R:R:T144	R:R:Y140	27.6245	18.73	No	Yes	0	6	8
60	R:R:H225	R:R:Y140	19.4735	7.62	Yes	Yes	0	5	8
61	R:R:I143	R:R:T144	13.8989	1.52	No	No	0	9	6
62	R:R:I143	R:R:I229	11.121	4.42	No	No	0	9	6
63	R:R:E288	R:R:Y185	18.9675	14.59	Yes	Yes	1	3	7
64	R:R:F221	R:R:H225	11.1819	13.58	No	Yes	0	4	5
65	R:R:E288	R:R:Y284	16.6815	4.49	Yes	Yes	0	3	4
66	R:R:K145	R:R:T144	11.1819	3	No	No	0	6	6
67	R:R:E110	R:R:T106	10.3246	1.41	No	Yes	0	7	4
68	R:R:Y34	W:W:?1	14.0441	14.77	Yes	Yes	1	3	0
69	R:R:K125	R:R:N309	13.6881	8.39	Yes	Yes	2	6	9
70	R:R:F274	R:R:N309	14.2502	9.67	Yes	Yes	2	9	9
71	R:R:I172	R:R:L211	24.5702	8.56	Yes	Yes	4	5	7
72	R:R:F274	R:R:Y275	25.1932	7.22	Yes	Yes	2	9	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:S26	R:R:Y34	5.09	1	No	Yes	8	3	1	1
R:R:P296	R:R:S26	7.13	0	No	No	2	8	2	1
R:R:S26	W:W:?1	3.94	1	No	Yes	8	0	1	0
R:R:C40	R:R:Y34	5.38	1	Yes	Yes	4	3	2	1
R:R:E43	R:R:Y34	6.73	1	Yes	Yes	5	3	2	1
R:R:Y34	W:W:?1	14.77	1	Yes	Yes	3	0	1	0
R:R:D38	R:R:E191	5.2	1	No	No	1	3	1	1
R:R:D38	W:W:?1	6.41	1	No	Yes	1	0	1	0
R:R:C40	R:R:E43	4.56	1	Yes	Yes	4	5	2	2
R:R:E43	R:R:F300	11.66	1	Yes	Yes	5	4	2	1
R:R:I47	R:R:T98	4.56	1	No	No	5	6	1	2
R:R:F300	R:R:I47	5.02	1	Yes	No	4	5	1	1
R:R:I47	W:W:?1	6	1	No	Yes	5	0	1	0
R:R:C94	R:R:I121	4.91	0	No	Yes	7	6	1	2
R:R:C94	W:W:?1	4.17	0	No	Yes	7	0	1	0
R:R:F117	R:R:G118	4.52	1	Yes	No	5	5	1	2
R:R:F117	R:R:I121	8.79	1	Yes	Yes	5	6	1	2
R:R:F117	R:R:I189	8.79	1	Yes	Yes	5	4	1	1
R:R:F117	R:R:F190	8.57	1	Yes	Yes	5	3	1	2
R:R:F117	W:W:?1	5.76	1	Yes	Yes	5	0	1	0
R:R:H186	R:R:I121	11.93	1	Yes	Yes	2	6	2	2
R:R:D188	R:R:K182	4.15	0	Yes	No	4	3	1	2
R:R:D188	R:R:Y185	4.6	0	Yes	Yes	4	7	1	2
R:R:Y185	R:R:Y281	7.94	1	Yes	Yes	7	6	2	2
R:R:H186	R:R:Y281	5.44	1	Yes	Yes	2	6	2	2
R:R:H186	R:R:T303	6.85	1	Yes	No	2	5	2	1
R:R:H186	R:R:I307	5.3	1	Yes	No	2	6	2	1
R:R:A194	R:R:D188	4.63	0	No	Yes	4	4	2	1
R:R:D188	W:W:?1	5.7	0	Yes	Yes	4	0	1	0
R:R:F190	R:R:I189	12.56	1	Yes	Yes	3	4	2	1
R:R:I189	W:W:?1	11.24	1	Yes	Yes	4	0	1	0
R:R:E191	W:W:?1	5.57	1	No	Yes	3	0	1	0
R:R:T303	R:R:Y281	7.49	1	No	Yes	5	6	1	2
R:R:F300	W:W:?1	10.23	1	Yes	Yes	4	0	1	0
R:R:T303	W:W:?1	3.87	1	No	Yes	5	0	1	0
R:R:I307	W:W:?1	4.5	0	No	Yes	6	0	1	0
R:R:I189	R:R:P97	3.39	1	Yes	No	4	4	1	2
R:R:F117	R:R:G187	3.01	1	Yes	No	5	4	1	2
R:R:L102	R:R:T44	2.95	0	No	Yes	4	6	2	1
R:R:T44	R:R:V45	1.59	0	Yes	No	6	6	1	2
R:R:T44	W:W:?1	1.55	0	Yes	Yes	6	0	1	0
R:R:I41	R:R:T44	1.52	0	No	Yes	6	6	2	1
R:R:F300	R:R:L301	1.22	1	Yes	No	4	3	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	8HMP_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.52
Number of Linked Nodes	270
Number of Links	297
Number of Hubs	44
Number of Links mediated by Hubs	158
Number of Communities	8
Number of Nodes involved in Communities	52
Number of Links involved in Communities	68

Path Summary
Number Of Nodes in MetaPath	73
Number Of Links MetaPath	72
Number of Shortest Paths	44456
Length Of Smallest Path	3
Average Path Length	14.0687
Length of Longest Path	28
Minimum Path Strength	1.3
Average Path Strength	6.52928
Maximum Path Strength	16.435
Minimum Path Correlation	0.7
Average Path Correlation	0.952988
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	64.5564
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	50.1124
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development
Gene Ontology	Biological Process	• multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • organelle membrane • intracellular anatomical structure • cytoplasm • cytosol • vacuolar membrane • lytic vacuole • vacuole • intracellular membrane-bounded organelle • intracellular organelle • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • protein binding • binding • G-protein beta-subunit binding • fibroblast proliferation • cell population proliferation • cellular process • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • G protein-coupled photoreceptor activity • molecular transducer activity • photoreceptor activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • response to xenobiotic stimulus • behavior • multicellular organismal process • locomotory behavior • response to light stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • phototransduction • detection of light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • endomembrane system • trans-Golgi network
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	EN6
PDB Residues	W:W:?1
Environment Details	Open EMBL-EBI Page
Code	EN6
Name	N-(2-hydroxyethyl)-5-(hydroxymethyl)-3-methyl-1-[2-[[3-(trifluoromethyl)phenyl]methyl]-1-benzothiophen-7-yl]pyrazole-4-carboxamide
Synonyms
Identifier
Formula	C24 H22 F3 N3 O3 S
Molecular Weight	489.51
SMILES
PubChem	69921479
Formal Charge	0
Total Atoms	56
Total Chiral Atoms	0
Total Bonds	59
Total Aromatic Bonds	21


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y2T5
Sequence	>8HMP_nogp_Chain_R S C P L G F G H Y S V V D V C I F E T V V I V L L T F L I I A G N L T V I F V F H C A P L L H H Y T T S Y F I Q T M A Y A D L F V G V S C L V P T L S L L H Y S T G V H E S L T C Q V F G Y I I S V L K S V S M W C L A C I S V D R Y L A I T K P L S Y N Q L V T P C R L R I C I I L I W I Y S C L I F L P S F F G W G K P G Y H G D I F E W C A T S W L T S A Y F T G F I V C L L Y A P A A F V V C F T Y F H I F K I C R Q H T K E I N D R R A R F P S H R Y A M V L F R I T S V F Y M L W L P Y I I Y F L L E S S R V L D N P T L S F L T T W L A I S N S F C N P V I Y S L S N S V F Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HMP	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17	Gs/β1/γ2	2.77	2023-06-21	doi.org/10.1002/mco2.260
	8HMP (No Gprot)	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17		2.77	2023-06-21	doi.org/10.1002/mco2.260
	6LI0	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17	-	2.2	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI1	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.9	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI2	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.8	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI3	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	Gs/β1/γ2	3.32	2020-02-26	doi.org/10.1038/s41586-020-2019-0
	6LI3 (No Gprot)	A	Orphan	Orphan	GPR52	Homo sapiens	-	-		3.32	2020-02-26	doi.org/10.1038/s41586-020-2019-0

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