Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Q19 5.99414
2A:A:L45 4.242548
3A:A:S51 2.55409
4A:A:M60 7.554549
5A:A:F212 9.2925409
6A:A:F219 7.9225408
7A:A:M221 5.7425448
8A:A:V224 3.8125409
9A:A:R228 5.23754189
10A:A:W234 6.0325409
11A:A:F238 8.50254169
12A:A:I245 4.1425447
13A:A:F246 6.7454179
14A:A:F273 6.0275409
15A:A:W277 9.82406
16A:A:I288 4.8325409
17A:A:F290 5.232549
18A:A:K293 4.354549
19A:A:F312 2.0425408
20A:A:F315 8.1554196
21A:A:Y318 6.5525406
22A:A:P321 3.795405
23A:A:P328 3.1585201
24A:A:V334 2.0125404
25A:A:F340 4.6545197
26A:A:R342 5.482554
27A:A:F345 6.175408
28A:A:L346 4.754554
29A:A:Y358 11.615454
30A:A:F363 6.2775455
31A:A:D368 4.172549
32A:A:R385 10.8375455
33B:B:R22 7.0125436
34B:B:D27 5.7654228
35B:B:I37 4.02622
36B:B:V40 4.5775423
37B:B:M45 5.4975424
38B:B:H54 8.565619
39B:B:K57 6.725409
40B:B:W63 6.255617
41B:B:L79 3.3475407
42B:B:I80 6.8725418
43B:B:W82 9.71719
44B:B:D83 5.3518
45B:B:Y85 12.06414
46B:B:K89 6.415619
47B:B:L95 3.1725408
48B:B:W99 6.11509
49B:B:M101 4.5725409
50B:B:I120 3.63506
51B:B:Y124 6.5075406
52B:B:H142 8.042579
53B:B:Y145 6.075408
54B:B:L146 3.9925477
55B:B:C148 3.195406
56B:B:F151 3.132509
57B:B:L152 3.6485133
58B:B:D163 7.7875479
59B:B:T165 4.8675477
60B:B:L168 3.9285136
61B:B:W169 10.7733678
62B:B:F180 7.132567
63B:B:H183 8.5725469
64B:B:D186 6.15254189
65B:B:V187 5.7225469
66B:B:L190 3.8775465
67B:B:F199 5.31469
68B:B:K209 7.228566
69B:B:W211 7.63333668
70B:B:F222 6.435438
71B:B:H225 7.32667639
72B:B:S227 4.154536
73B:B:I232 3.91667638
74B:B:F235 8.7965116
75B:B:P236 6.0154117
76B:B:N237 8.77254115
77B:B:F241 6.956536
78B:B:T243 3.5575438
79B:B:S245 5.125439
80B:B:D247 5.9325439
81B:B:T249 4.6875436
82B:B:R251 7.91538
83B:B:F253 6.034536
84B:B:D254 4.8825259
85B:B:R256 5.8925259
86B:B:D258 10.0875437
87B:B:E260 5.7725436
88B:B:Y264 4.038585
89B:B:F278 6.607147117
90B:B:G282 3.8254119
91B:B:R283 7.622529
92B:B:Y289 7.85667687
93B:B:N293 5.908585
94B:B:C294 3.8975425
95B:B:N295 8.36586
96B:B:W297 6.2575488
97B:B:K301 6.77333625
98B:B:H311 8.8825429
99B:B:R314 8.8145108
100B:B:L318 3.25526
101B:B:V327 4.6125426
102B:B:T329 4.964528
103B:B:W332 6.9765109
104B:B:D333 9.5775409
105B:B:L336 5.0475417
106B:B:K337 5426
107B:B:W339 8.04667629
108B:B:N340 5.5025419
109G:G:Q18 5.04569
110G:G:R27 6.932538
111G:G:Y40 7.29254116
112G:G:D48 5.176509
113G:G:N59 6.104519
114G:G:F61 5.11167618
115G:G:R62 8.885417
116R:R:T44 2.6825406
117R:R:F79 5.8325408
118R:R:T98 3.07506
119R:R:F117 5.2425405
120R:R:L132 5.6125408
121R:R:I135 3.275409
122R:R:R139 5.24409
123R:R:Y149 8.88408
124R:R:L158 3.6475407
125R:R:F173 4.71833696
126R:R:K182 9.852593
127R:R:P183 4.6625494
128R:R:Y185 8.138597
129R:R:H186 4.82502
130R:R:F190 5.6845143
131R:R:F203 4.322505
132R:R:Y212 5.648336125
133R:R:Y223 5.607147299
134R:R:H233 6.732557
135R:R:R240 7.2175453
136R:R:F244 5.682503
137R:R:L267 3.568508
138R:R:F274 5.89409
139R:R:W278 7.87754128
140R:R:Y281 8.2985126
141R:R:F285 8.615405
142R:R:W304 5.47667604
143R:R:N309 5.285409
144R:R:F311 5.5725276
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:C317 B:B:M61 17.22184.86NoNo076
2B:B:C317 B:B:S316 17.65423.44NoNo079
3B:B:S316 B:B:W332 17.91687.41NoYes099
4B:B:K57 B:B:W332 11.785810.44YesYes099
5B:B:K57 B:B:Q75 10.53789.49YesNo099
6B:B:Q75 B:B:W99 10.77165.48NoYes099
7A:A:Q236 B:B:W332 24.30184.38NoYes1089
8A:A:Q236 A:A:W281 24.24344.38NoNo1085
9A:A:N279 A:A:W281 48.45293.39NoNo085
10A:A:L282 A:A:N279 48.33816.87NoNo098
11A:A:I244 A:A:L282 48.42874.28NoNo089
12A:A:I244 A:A:V287 48.01044.61NoNo086
13A:A:F273 A:A:V287 48.09235.24YesNo096
14A:A:C359 A:A:F273 1002.79NoYes059
15A:A:C359 A:A:L346 99.18043.17NoYes054
16A:A:L346 R:R:R240 91.24663.64YesYes543
17A:A:Y358 R:R:R240 93.05813.38YesYes543
18A:A:Y358 A:A:Y360 49.318115.89YesNo548
19A:A:D378 A:A:Y360 57.53949.2NoNo078
20A:A:D378 A:A:I288 28.9015.6NoYes079
21A:A:F290 A:A:I288 28.07577.54YesYes099
22A:A:F290 A:A:I245 36.82375.02YesYes497
23A:A:I245 A:A:L43 18.44442.85YesNo077
24B:B:R314 B:B:W332 24.58427YesYes1089
25A:A:W281 B:B:R314 24.40874NoYes1058
26A:A:D378 A:A:H362 28.452913.87NoNo079
27A:A:F290 A:A:H362 28.04033.39YesNo099
28A:A:L43 A:A:M221 11.26185.65NoYes078
29A:A:I245 A:A:L45 17.99394.28YesYes478
30A:A:L45 A:A:M221 22.55265.65YesYes488
31A:A:F290 A:A:V247 18.41263.93YesNo097
32A:A:L45 A:A:V247 17.97142.98YesNo087
33A:A:R231 A:A:W234 55.87344NoYes099
34A:A:L272 A:A:R231 55.82386.07NoNo089
35A:A:M221 A:A:M60 28.37268.66YesYes489
36A:A:M60 A:A:Q59 25.70636.8YesNo499
37A:A:N371 A:A:Q59 24.358410.56NoNo499
38A:A:N371 A:A:T364 13.53385.85NoNo499
39A:A:N292 A:A:T364 12.19067.31NoNo499
40B:B:L117 B:B:M101 16.02912.83NoYes099
41B:B:G116 B:B:M101 22.55493.49NoYes099
42B:B:G115 B:B:G116 22.31652.11NoNo099
43B:B:G115 B:B:L146 22.12963.42NoYes097
44B:B:C121 B:B:L146 20.12083.17NoYes087
45B:B:A113 B:B:C121 19.90531.81NoNo098
46B:B:A113 B:B:F151 12.41792.77NoYes099
47B:B:F151 B:B:Y111 12.98432.06YesNo094
48B:B:N125 B:B:Y111 12.19198.14NoNo044
49B:B:K127 B:B:N125 11.66229.79NoNo044
50B:B:K127 B:B:N110 11.39711.19NoNo044
51B:B:N110 B:B:S108 11.13148.94NoNo046
52A:A:Q227 B:B:L117 12.73453.99NoNo099
53A:A:Q227 B:B:Y145 46.7053.38NoYes098
54B:B:M101 B:B:Y145 12.97034.79YesYes098
55B:B:D186 B:B:Y145 38.580510.34YesYes098
56B:B:C204 B:B:D186 37.18233.11NoYes079
57B:B:C204 B:B:D228 37.07556.22NoNo079
58A:A:R385 A:A:Y358 42.849112.35YesYes554
59A:A:R385 R:R:H233 51.038114.67YesYes557
60A:A:Q384 R:R:H233 50.0236.18NoYes567
61A:A:Q384 R:R:P146 49.85634.74NoNo068
62A:A:I383 R:R:P146 49.46015.08NoNo088
63A:A:H387 A:A:I383 49.26162.65NoNo088
64A:A:H387 R:R:A142 46.45252.93NoNo088
65R:R:A142 R:R:Y149 46.24976.67NoYes088
66B:B:S281 G:G:D48 17.62494.42NoYes099
67B:B:G282 B:B:S281 16.19313.71YesNo099
68B:B:A257 B:B:D254 14.90623.09NoYes079
69B:B:A257 G:G:V30 15.18113.39NoNo078
70B:B:Q259 G:G:V30 16.94195.73NoNo068
71B:B:Q259 B:B:R22 17.5434.67NoYes066
72B:B:A113 B:B:C149 10.42391.81NoNo098
73B:B:C149 B:B:T102 11.61638.45NoNo088
74B:B:C148 B:B:T102 11.43683.38YesNo068
75B:B:C148 B:B:L190 10.32233.17YesYes065
76B:B:D258 B:B:R22 19.878210.72YesYes376
77B:B:D254 B:B:L261 12.87994.07YesNo095
78B:B:L252 B:B:L261 11.78958.3NoNo075
79B:B:L252 B:B:Y264 11.42544.69NoYes075
80G:G:D48 G:G:L50 19.50054.07YesNo099
81B:B:M45 G:G:L50 10.12595.65YesNo049
82B:B:M45 B:B:W339 18.55153.49YesYes249
83B:B:K337 B:B:W339 10.10394.64YesYes269
84B:B:N313 B:B:W332 36.44385.65NoYes079
85B:B:D333 B:B:N313 36.06128.08YesNo097
86B:B:D258 B:B:F222 23.29754.78YesYes378
87B:B:I232 B:B:S189 11.50143.1YesNo087
88B:B:D228 B:B:S227 36.62934.42NoYes096
89B:B:H225 B:B:S227 28.0392.79YesYes396
90B:B:H225 B:B:T243 14.12532.74YesYes398
91B:B:C148 B:B:S189 11.26693.44YesNo067
92B:B:F222 B:B:F253 21.55647.5YesYes386
93B:B:V327 G:G:L50 10.1612.98YesNo069
94B:B:L318 B:B:V327 10.68142.98YesYes266
95B:B:T329 B:B:W339 10.0267.28YesYes289
96B:B:H311 B:B:T329 16.71398.21YesYes298
97B:B:H311 B:B:K337 10.42187.86YesYes296
98B:B:D333 B:B:S331 34.612610.31YesNo099
99R:R:V153 R:R:Y149 38.930912.62NoYes078
100R:R:L158 R:R:V153 38.72494.47YesNo077
101R:R:F79 R:R:L158 37.4543.65YesYes087
102R:R:F79 R:R:I135 36.26095.02YesYes089
103R:R:I135 R:R:L132 35.99092.85YesYes098
104R:R:F274 R:R:L132 28.09399.74YesYes098
105R:R:F274 R:R:W278 28.36975.01YesYes098
106R:R:W278 R:R:Y281 24.48447.72YesYes1286
107R:R:H186 R:R:Y281 17.60188.71YesYes026
108B:B:F253 B:B:R251 15.20594.28YesYes368
109B:B:H311 B:B:S331 27.291111.16YesNo299
110A:A:F246 A:A:F273 54.98929.65YesYes099
111A:A:F246 A:A:L272 54.85737.31YesNo1798
112A:A:Q227 A:A:W234 53.43238.76NoYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 6LI3
Class A
SubFamily Orphan
Type A orphans
SubType GPR52
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.32
Date 2020-02-26
D.O.I. 10.1038/s41586-020-2019-0
Net Summary
Imin 2.65
Number of Linked Nodes 852
Number of Links 989
Number of Hubs 144
Number of Links mediated by Hubs 533
Number of Communities 29
Number of Nodes involved in Communities 213
Number of Links involved in Communities 295
Path Summary
Number Of Nodes in MetaPath 113
Number Of Links MetaPath 112
Number of Shortest Paths 1061818
Length Of Smallest Path 3
Average Path Length 29.7278
Length of Longest Path 60
Minimum Path Strength 1.23
Average Path Strength 5.97378
Maximum Path Strength 21.795
Minimum Path Correlation 0.7
Average Path Correlation 0.975776
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.43902
Average % Of Corr. Nodes 41.8698
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.1546
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>6LI3_Chain_A
TEDQRNEEK AQREANKKI EKQLQKDKQ VYRATHRLL LLGADNSGK 
STIVKQMRI LHSGGTSGI FETKFQVDK VNFHMFDVG GQRDERRKW 
IQCFNDVTA IIFVVDSSD YNRLQEALN LFKSIWNNR WLRTISVIL 
FLNKQDLLA EKVLAGKSK IEDYFPEFA RYTTPEDAT PEPGEDPRV 
TRAKYFIRD EFLRISTAS GDGRHYCYP HFTCAVDTE NARRIFNDC 
RDIIQRMHL RQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>6LI3_Chain_B
ELDQLRQEA EQLKNQIRD ARKACADAT LSQITNNID PVGRIQMRT 
RRTLRGHLA KIYAMHWGT DSRLLVSAS QDGKLIIWD SYTTNKVHA 
IPLRSSWVM TCAYAPSGN YVACGGLDN ICSIYNLKT REGNVRVSR 
ELAGHTGYL SCCRFLDDN QIVTSSGDT TCALWDIET GQQTTTFTG 
HTGDVMSLS LAPDTRLFV SGACDASAK LWDVREGMC RQTFTGHES 
DINAICFFP NGNAFATGS DDATCRLFD LRADQELMT YSHDNIICG 
ITSVSFSKS GRLLLAGYD DFNCNVWDA LKADRAGVL AGHDNRVSC 
LGVTDDGMA VATGSWDSF LKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>6LI3_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ9Y2T5
Sequence
>6LI3_Chain_R
VDVCIFETV VIVLLTFLI IAGNLTVIF VFHCAPLLH HYTTSYFIQ 
TMAYADLFV GVSCLVPTL SLLHYSTGV HESLTCQVF GYIISVLKS 
VSMWCLACI SVDRYLAIT KPLSYNQLV TPCRLRICI ILIWIYSCL 
IFLPSFFGW GKPGYHGDI FEWCATSWL TSAYFTGFI VCLLYAPAA 
FVVCFTYFH IFKICRQHT KEINDRRAR FPSHMVLFR ITSVFYMLW 
LPYIIYFLL ESSRVLDNP TLSFLTTWL AISNSFCNP VIYSLSNSV 
FRLGLRRLS ETMCT


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
6LI0AOrphanA orphansGPR52Homo sapiens-GTPL9804-2.22020-02-2610.1038/s41586-020-2019-0
6LI1AOrphanA orphansGPR52Homo sapiens---2.92020-02-2610.1038/s41586-020-2019-0
6LI2AOrphanA orphansGPR52Homo sapiens---2.82020-02-2610.1038/s41586-020-2019-0
6LI3AOrphanA orphansGPR52Homo sapiens--Gs/&β;1/&γ;23.322020-02-2610.1038/s41586-020-2019-0
8HMPAOrphanA orphansGPR52Homo sapiens-PubChem 69921479Gs/&β;1/&γ;22.772023-06-2110.1002/mco2.260




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LI3.zip



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