psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E23	R:R:S100	7.19	No	No	0	7	4
2	R:R:E23	R:R:S105	11.5	No	No	0	7	4
3	R:R:E191	R:R:R24	19.77	No	No	0	3	6
4	R:R:H25	R:R:S100	6.97	No	No	0	6	4
5	R:R:H25	R:R:L101	11.57	No	Yes	0	6	4
6	R:R:C27	R:R:C40	7.28	No	No	0	6	4
7	R:R:C27	R:R:E43	10.64	No	Yes	0	6	5
8	R:R:P28	R:R:P296	3.9	No	No	0	7	2
9	R:R:E43	R:R:L29	11.93	Yes	No	1	5	5
10	R:R:F300	R:R:L29	3.65	Yes	No	1	4	5
11	R:R:F31	R:R:G30	4.52	No	No	0	5	5
12	R:R:F31	R:R:T297	3.89	No	No	0	5	1
13	R:R:D38	R:R:Y34	8.05	No	Yes	1	1	3
14	R:R:V39	R:R:Y34	5.05	No	Yes	0	4	3
15	R:R:I41	R:R:Y34	3.63	No	Yes	1	6	3
16	R:R:F42	R:R:Y34	7.22	No	Yes	1	4	3
17	R:R:E43	R:R:Y34	10.1	Yes	Yes	1	5	3
18	R:R:D38	R:R:S35	5.89	No	No	0	1	5
19	R:R:D38	R:R:I41	4.2	No	No	1	1	6
20	R:R:F42	R:R:I41	3.77	No	No	1	4	6
21	R:R:E43	R:R:F300	7	Yes	Yes	1	5	4
22	R:R:L101	R:R:T44	8.84	Yes	No	0	4	6
23	R:R:I47	R:R:P97	5.08	Yes	Yes	0	5	4
24	R:R:I47	R:R:T98	4.56	Yes	Yes	1	5	6
25	R:R:I47	R:R:L101	5.71	Yes	Yes	1	5	4
26	R:R:I189	R:R:I47	5.89	Yes	Yes	1	4	5
27	R:R:F300	R:R:I47	3.77	Yes	Yes	1	4	5
28	R:R:I47	R:R:W304	18.79	Yes	Yes	1	5	4
29	R:R:T98	R:R:V48	4.76	Yes	No	0	6	4
30	R:R:C94	R:R:T51	5.07	No	No	0	7	6
31	R:R:T51	R:R:T98	9.42	No	Yes	1	6	6
32	R:R:F311	R:R:L53	14.61	No	No	0	6	5
33	R:R:G91	R:R:I54	3.53	No	No	0	6	7
34	R:R:I54	R:R:S310	4.64	No	Yes	0	7	9
35	R:R:I55	R:R:L95	4.28	No	No	0	6	7
36	R:R:G57	R:R:P314	4.06	No	No	0	8	9
37	R:R:D87	R:R:N58	6.73	Yes	No	0	9	9
38	R:R:L88	R:R:N58	4.12	No	No	0	6	9
39	R:R:N58	R:R:P314	13.03	No	No	0	9	9
40	R:R:L59	R:R:L88	5.54	No	No	0	5	6
41	R:R:F65	R:R:V61	3.93	Yes	No	2	7	9
42	R:R:H66	R:R:V61	4.15	Yes	No	2	3	9
43	R:R:P314	R:R:V61	3.53	No	No	0	9	9
44	R:R:H66	R:R:I62	6.63	Yes	No	0	3	8
45	R:R:I62	R:R:Y85	8.46	No	No	0	8	6
46	R:R:F65	R:R:V64	10.49	Yes	No	2	7	8
47	R:R:F324	R:R:V64	3.93	Yes	No	2	8	8
48	R:R:F65	R:R:H66	4.53	Yes	Yes	2	7	3
49	R:R:F65	R:R:Y317	7.22	Yes	Yes	2	7	9
50	R:R:D321	R:R:F65	3.58	No	Yes	2	8	7
51	R:R:F324	R:R:F65	5.36	Yes	Yes	2	8	7
52	R:R:H66	R:R:Q81	9.89	Yes	No	0	3	6
53	R:R:H66	R:R:Y317	4.36	Yes	Yes	2	3	9
54	R:R:H72	R:R:H73	8.36	No	No	2	8	7
55	R:R:H72	R:R:Y263	17.42	No	Yes	2	8	7
56	R:R:H73	R:R:Y263	14.16	No	Yes	2	7	7
57	R:R:Y74	R:R:Y78	3.97	No	No	0	4	4
58	R:R:D138	R:R:T75	11.56	No	No	5	9	6
59	R:R:T75	R:R:Y149	3.75	No	Yes	5	6	8
60	R:R:I135	R:R:T76	7.6	No	No	0	9	8
61	R:R:R139	R:R:T76	6.47	Yes	No	0	9	8
62	R:R:T76	R:R:Y263	6.24	No	Yes	0	8	7
63	R:R:L158	R:R:Y78	7.03	No	No	0	7	4
64	R:R:C134	R:R:F79	11.17	No	Yes	0	6	8
65	R:R:F79	R:R:I135	6.28	Yes	No	0	8	9
66	R:R:F79	R:R:L158	4.87	Yes	No	0	8	7
67	R:R:I80	R:R:Y317	8.46	No	Yes	0	8	9
68	R:R:I162	R:R:T82	9.12	No	No	0	8	9
69	R:R:M83	R:R:S128	6.13	Yes	No	0	9	9
70	R:R:C131	R:R:M83	4.86	No	Yes	0	8	9
71	R:R:L132	R:R:M83	7.07	No	Yes	0	8	9
72	R:R:M83	R:R:N313	5.61	Yes	No	0	9	9
73	R:R:D87	R:R:S128	5.89	Yes	No	0	9	9
74	R:R:D87	R:R:S310	8.83	Yes	Yes	0	9	9
75	R:R:D87	R:R:N313	9.42	Yes	No	0	9	9
76	R:R:F89	R:R:V92	7.87	No	No	0	7	4
77	R:R:I121	R:R:V90	4.61	Yes	No	0	6	8
78	R:R:S310	R:R:V90	8.08	Yes	No	0	9	8
79	R:R:I120	R:R:S93	4.64	No	No	0	5	4
80	R:R:I121	R:R:S93	4.64	Yes	No	0	6	4
81	R:R:P97	R:R:V96	5.3	Yes	No	0	4	7
82	R:R:F117	R:R:P97	11.56	No	Yes	0	5	4
83	R:R:F190	R:R:P97	4.33	Yes	Yes	0	3	4
84	R:R:L99	R:R:Y104	7.03	No	No	0	6	4
85	R:R:F190	R:R:S100	5.28	Yes	No	0	3	4
86	R:R:I189	R:R:L101	4.28	Yes	Yes	1	4	4
87	R:R:E110	R:R:F190	10.49	No	Yes	0	7	3
88	R:R:E110	R:R:E191	6.34	No	No	0	7	3
89	R:R:S111	R:R:W192	12.36	No	Yes	0	3	4
90	R:R:F190	R:R:T113	3.89	Yes	No	0	3	5
91	R:R:C114	R:R:F190	8.38	Yes	Yes	0	9	3
92	R:R:C114	R:R:W192	3.92	Yes	Yes	0	9	4
93	R:R:C114	R:R:C193	7.28	Yes	No	6	9	9
94	R:R:F177	R:R:Q115	8.2	No	No	0	5	6
95	R:R:F117	R:R:I121	11.3	No	Yes	0	5	6
96	R:R:V123	R:R:Y119	6.31	No	No	0	5	6
97	R:R:F177	R:R:Y119	13.41	No	No	0	5	6
98	R:R:H186	R:R:I121	10.61	Yes	Yes	0	2	6
99	R:R:F173	R:R:S122	11.89	No	No	0	6	5
100	R:R:H186	R:R:S122	5.58	Yes	No	0	2	5
101	R:R:F173	R:R:V123	3.93	No	No	0	6	5
102	R:R:K125	R:R:N309	8.39	No	Yes	0	6	9
103	R:R:K125	R:R:S310	4.59	No	Yes	0	6	9
104	R:R:S126	R:R:W130	4.94	No	Yes	3	6	5
105	R:R:L211	R:R:S126	9.01	No	No	3	7	6
106	R:R:I165	R:R:V127	4.61	No	No	0	6	6
107	R:R:V127	R:R:W166	12.26	No	No	0	6	9
108	R:R:M129	R:R:Y212	5.99	Yes	Yes	0	7	5
109	R:R:A215	R:R:M129	4.83	No	Yes	3	5	7
110	R:R:F274	R:R:M129	3.73	Yes	Yes	3	9	7
111	R:R:M129	R:R:Y275	13.17	Yes	No	3	7	5
112	R:R:M129	R:R:Q278	5.44	Yes	No	3	7	8
113	R:R:I165	R:R:W130	4.7	No	Yes	0	6	5
114	R:R:W130	R:R:Y168	6.75	Yes	No	0	5	4
115	R:R:L211	R:R:W130	5.69	No	Yes	3	7	5
116	R:R:A215	R:R:W130	3.89	No	Yes	3	5	5
117	R:R:L132	R:R:T271	5.9	No	No	0	8	8
118	R:R:F274	R:R:L132	7.31	Yes	No	0	9	8
119	R:R:I135	R:R:L267	5.71	No	No	0	9	8
120	R:R:S136	R:R:T222	9.59	No	No	4	8	7
121	R:R:S136	R:R:Y223	5.09	No	Yes	4	8	9
122	R:R:D138	R:R:R139	4.76	No	Yes	5	9	9
123	R:R:D138	R:R:Y149	11.49	No	Yes	5	9	8
124	R:R:A142	R:R:R139	4.15	No	Yes	5	8	9
125	R:R:R139	R:R:Y149	5.14	Yes	Yes	5	9	8
126	R:R:T144	R:R:Y140	13.73	No	Yes	0	6	8
127	R:R:F221	R:R:Y140	6.19	No	Yes	4	4	8
128	R:R:T222	R:R:Y140	7.49	No	Yes	4	7	8
129	R:R:H225	R:R:Y140	5.44	Yes	Yes	4	5	8
130	R:R:I226	R:R:Y140	3.63	No	Yes	0	9	8
131	R:R:K145	R:R:L141	4.23	Yes	No	0	6	5
132	R:R:A142	R:R:Y149	9.34	No	Yes	5	8	8
133	R:R:I143	R:R:I229	5.89	No	No	0	9	6
134	R:R:V153	R:R:Y149	11.36	No	Yes	0	7	8
135	R:R:I172	R:R:Y168	12.09	No	No	0	5	4
136	R:R:I172	R:R:I207	4.42	No	Yes	0	5	6
137	R:R:F173	R:R:I207	7.54	No	Yes	0	6	6
138	R:R:P175	R:R:W180	5.4	No	No	7	6	6
139	R:R:F203	R:R:P175	11.56	Yes	No	7	5	6
140	R:R:P183	R:R:S176	7.13	No	No	8	4	5
141	R:R:S176	R:R:W197	4.94	No	Yes	8	5	5
142	R:R:F203	R:R:W180	4.01	Yes	No	7	5	6
143	R:R:D188	R:R:K182	9.68	No	No	0	4	3
144	R:R:K182	R:R:W197	12.76	No	Yes	0	3	5
145	R:R:K182	R:R:T199	9.01	No	Yes	0	3	3
146	R:R:P183	R:R:W197	6.76	No	Yes	8	4	5
147	R:R:F285	R:R:G184	4.52	Yes	No	0	5	2
148	R:R:D188	R:R:Y185	9.2	No	Yes	0	4	7
149	R:R:T199	R:R:Y185	3.75	Yes	Yes	1	3	7
150	R:R:Y185	R:R:Y281	6.95	Yes	Yes	1	7	6
151	R:R:Y185	R:R:Y284	11.91	Yes	Yes	1	7	4
152	R:R:F285	R:R:Y185	13.41	Yes	Yes	1	5	7
153	R:R:E288	R:R:Y185	14.59	Yes	Yes	1	3	7
154	R:R:S299	R:R:Y185	5.09	No	Yes	1	4	7
155	R:R:T303	R:R:Y185	3.75	No	Yes	1	5	7
156	R:R:H186	R:R:Y281	14.16	Yes	Yes	0	2	6
157	R:R:H186	R:R:I307	3.98	Yes	No	0	2	6
158	R:R:A194	R:R:D188	6.18	No	No	0	4	4
159	R:R:F190	R:R:I189	3.77	Yes	Yes	0	3	4
160	R:R:F300	R:R:I189	5.02	Yes	Yes	1	4	4
161	R:R:E191	R:R:T195	7.06	No	No	0	3	4
162	R:R:S196	R:R:W192	13.59	No	Yes	0	3	4
163	R:R:W192	R:R:W197	8.43	Yes	Yes	0	4	5
164	R:R:L198	R:R:R291	4.86	No	No	0	5	1
165	R:R:F285	R:R:T199	3.89	Yes	Yes	1	5	3
166	R:R:E288	R:R:T199	12.7	Yes	Yes	1	3	3
167	R:R:S289	R:R:T199	7.99	No	Yes	0	4	3
168	R:R:R291	R:R:T199	5.17	No	Yes	1	1	3
169	R:R:F203	R:R:F206	4.29	Yes	No	0	5	5
170	R:R:F203	R:R:I207	10.05	Yes	Yes	0	5	6
171	R:R:F285	R:R:T204	16.86	Yes	No	0	5	5
172	R:R:S289	R:R:T204	9.59	No	No	0	4	5
173	R:R:F206	R:R:L210	7.31	No	No	0	5	5
174	R:R:I207	R:R:Y212	3.63	Yes	Yes	0	6	5
175	R:R:V208	R:R:Y212	3.79	No	Yes	0	4	5
176	R:R:L286	R:R:V208	5.96	No	No	0	5	4
177	R:R:I282	R:R:Y212	7.25	No	Yes	0	6	5
178	R:R:A215	R:R:Y275	4	No	No	3	5	5
179	R:R:T271	R:R:V219	4.76	No	No	0	8	5
180	R:R:V219	R:R:Y275	12.62	No	No	0	5	5
181	R:R:F221	R:R:H225	12.44	No	Yes	4	4	5
182	R:R:T222	R:R:Y223	4.99	No	Yes	4	7	9
183	R:R:F268	R:R:Y223	9.28	No	Yes	0	5	9
184	R:R:T271	R:R:Y223	7.49	No	Yes	0	8	9
185	R:R:F224	R:R:H225	9.05	No	Yes	4	4	5
186	R:R:F224	R:R:K228	3.72	No	No	4	4	4
187	R:R:H225	R:R:K228	7.86	Yes	No	4	5	4
188	R:R:I226	R:R:L264	4.28	No	No	0	9	7
189	R:R:F227	R:R:L264	8.53	No	No	0	7	7
190	R:R:F227	R:R:F268	11.79	No	No	0	7	5
191	R:R:L267	R:R:Y263	10.55	No	Yes	0	8	7
192	R:R:Y263	R:R:Y317	4.96	Yes	Yes	2	7	9
193	R:R:S320	R:R:V266	8.08	No	No	0	7	8
194	R:R:F268	R:R:S272	7.93	No	No	0	5	5
195	R:R:I316	R:R:R269	5.01	No	No	0	8	7
196	R:R:R269	R:R:S320	5.27	No	No	0	7	7
197	R:R:I316	R:R:V273	4.61	No	No	0	8	7
198	R:R:F274	R:R:Q278	5.86	Yes	No	3	9	8
199	R:R:F274	R:R:N309	24.17	Yes	Yes	3	9	9
200	R:R:F274	R:R:N313	10.87	Yes	No	0	9	9
201	R:R:L277	R:R:S308	6.01	No	No	0	8	6
202	R:R:L277	R:R:N309	5.49	No	Yes	0	8	9
203	R:R:N309	R:R:Q278	5.28	Yes	No	3	9	8
204	R:R:I283	R:R:L279	5.71	No	No	0	5	6
205	R:R:L305	R:R:P280	4.93	No	No	0	7	9
206	R:R:T302	R:R:Y281	3.75	No	Yes	0	5	6
207	R:R:T303	R:R:Y281	4.99	No	Yes	1	5	6
208	R:R:E288	R:R:Y284	8.98	Yes	Yes	1	3	4
209	R:R:S299	R:R:Y284	11.45	No	Yes	1	4	4
210	R:R:L287	R:R:L293	5.54	No	No	0	4	1
211	R:R:E288	R:R:R291	4.65	Yes	No	1	3	1
212	R:R:N295	R:R:P296	4.89	No	No	0	3	2
213	R:R:N295	R:R:T297	7.31	No	No	0	3	1
214	R:R:L298	R:R:N295	15.1	No	No	0	4	3
215	R:R:F300	R:R:W304	15.03	Yes	Yes	1	4	4
216	R:R:T303	R:R:W304	7.28	No	Yes	1	5	4
217	R:R:I307	R:R:W304	15.27	No	Yes	0	6	4
218	R:R:F311	R:R:V315	5.24	No	No	0	6	7
219	R:R:A318	R:R:F324	8.32	No	Yes	0	7	8
220	R:R:D321	R:R:T323	8.67	No	No	0	8	7
221	R:R:D321	R:R:F324	3.58	No	Yes	2	8	8
222	R:R:R325	R:R:S322	5.27	No	No	0	9	5
223	R:R:F324	R:R:L328	7.31	Yes	No	0	8	7
224	R:R:L326	R:R:R329	7.29	No	No	0	4	5
225	R:R:L326	R:R:R330	9.72	No	No	0	4	5
226	R:R:L102	R:R:Y104	3.52	No	No	0	4	4
227	R:R:L293	R:R:Y284	3.52	No	Yes	0	1	4
228	R:R:P155	R:R:T154	3.5	No	No	0	3	8
229	R:R:P280	R:R:T302	3.5	No	No	0	9	5
230	R:R:A194	R:R:S26	3.42	No	No	0	4	8
231	R:R:C312	R:R:V273	3.42	No	No	0	5	7
232	R:R:A86	R:R:V127	3.39	No	No	0	8	6
233	R:R:A133	R:R:V218	3.39	No	No	0	7	8
234	R:R:C131	R:R:T82	3.38	No	No	0	8	9
235	R:R:L279	R:R:P280	3.28	No	No	0	6	9
236	R:R:S126	R:R:S169	3.26	No	No	0	6	8
237	R:R:S136	R:R:V137	3.23	No	No	0	8	6
238	R:R:R325	R:R:R329	3.2	No	No	0	9	5
239	R:R:T106	R:R:V108	3.17	No	No	0	4	1
240	R:R:T113	R:R:V108	3.17	No	No	0	5	1
241	R:R:C312	R:R:L277	3.17	No	No	0	5	8
242	R:R:E43	R:R:P28	3.14	Yes	No	0	5	7
243	R:R:I120	R:R:V116	3.07	No	No	0	5	4
244	R:R:I270	R:R:V266	3.07	No	No	0	8	8
245	R:R:K145	R:R:S148	3.06	Yes	No	0	6	5
246	R:R:F117	R:R:G118	3.01	No	No	0	5	5
247	R:R:L50	R:R:S308	3	No	No	0	6	6
248	R:R:K145	R:R:T144	3	Yes	No	0	6	6
249	R:R:L152	R:R:S148	3	No	No	0	4	5
250	R:R:L88	R:R:V92	2.98	No	No	0	6	4
251	R:R:L124	R:R:V90	2.98	No	No	0	7	8
252	R:R:L112	R:R:V108	2.98	No	No	0	1	1
253	R:R:L287	R:R:V292	2.98	No	No	0	4	3
254	R:R:L95	R:R:T51	2.95	No	No	1	7	6
255	R:R:L95	R:R:T98	2.95	No	Yes	1	7	6
256	R:R:A84	R:R:H66	2.93	No	Yes	0	9	3
257	R:R:W180	R:R:Y202	2.89	No	No	0	6	6
258	R:R:E333	R:R:S332	2.87	No	No	0	4	5
259	R:R:I167	R:R:L171	2.85	No	No	0	4	4
260	R:R:L331	R:R:M335	2.83	No	No	0	6	4
261	R:R:C161	R:R:F79	2.79	No	Yes	0	6	8
262	R:R:H109	R:R:S111	2.79	No	No	0	6	3
263	R:R:P214	R:R:W130	2.7	No	Yes	0	9	5
264	R:R:C170	R:R:Y119	2.69	No	No	0	4	6
265	R:R:A306	R:R:Y281	2.67	No	Yes	0	7	6
266	R:R:H233	R:R:I229	2.65	No	No	0	7	6
267	R:R:N150	R:R:Q151	2.64	No	No	0	4	4
268	R:R:F203	R:R:S200	2.64	Yes	No	0	5	3
269	R:R:F300	R:R:V46	2.62	Yes	No	0	4	4
270	R:R:D294	R:R:E288	2.6	No	Yes	0	3	3
271	R:R:A133	R:R:W130	2.59	No	Yes	0	7	5
272	R:R:R157	R:R:T154	2.59	No	No	0	5	8
273	R:R:F311	R:R:I54	2.51	No	No	0	6	7
274	R:R:F227	R:R:M265	2.49	No	No	0	7	7
275	R:R:H233	R:R:Q232	2.47	No	No	0	7	4
276	R:R:F63	R:R:L59	2.44	No	No	0	4	5
277	R:R:F178	R:R:L174	2.44	No	No	0	5	4
278	R:R:F324	R:R:L319	2.44	Yes	No	0	8	5
279	R:R:Q232	R:R:R231	2.34	No	No	0	4	5
280	R:R:C114	R:R:G187	1.96	Yes	No	6	9	4
281	R:R:C193	R:R:G187	1.96	No	No	6	9	4
282	R:R:A56	R:R:G57	1.95	No	No	0	4	8
283	R:R:A213	R:R:P214	1.87	No	No	0	5	9
284	R:R:G181	R:R:S200	1.86	No	No	0	6	3
285	R:R:K145	R:R:P146	1.67	Yes	No	0	6	8
286	R:R:C156	R:R:I160	1.64	No	No	0	4	3
287	R:R:L174	R:R:P175	1.64	No	No	0	4	6
288	R:R:C230	R:R:I226	1.64	No	No	0	8	9
289	R:R:S35	R:R:V37	1.62	No	No	0	5	2
290	R:R:S290	R:R:V292	1.62	No	No	0	4	3
291	R:R:C336	R:R:M340	1.62	No	No	0	4	2
292	R:R:V45	R:R:V46	1.6	No	No	0	6	4
293	R:R:G32	R:R:H33	1.59	No	No	0	4	4
294	R:R:T60	R:R:V64	1.59	No	No	0	6	8
295	R:R:C209	R:R:L210	1.59	No	No	0	4	5
296	R:R:I229	R:R:T144	1.52	No	No	0	6	6
297	R:R:L147	R:R:S148	1.5	No	No	0	7	5
298	R:R:L102	R:R:V48	1.49	No	No	0	4	4
299	R:R:I163	R:R:I167	1.47	No	No	0	3	4
300	R:R:L279	R:R:M276	1.41	No	No	0	6	4
301	R:R:C67	R:R:F63	1.4	No	No	0	5	4
302	R:R:H72	R:R:S77	1.39	No	No	0	8	8
303	R:R:P155	R:R:Y74	1.39	No	No	0	3	4
304	R:R:L29	R:R:L301	1.38	No	No	0	5	3
305	R:R:L171	R:R:L174	1.38	No	No	0	4	4
306	R:R:F52	R:R:L53	1.22	No	No	0	5	5
307	R:R:R159	R:R:Y78	1.03	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y34	6.81	5	1	3
2	R:R:E43	8.562	5	1	5
3	R:R:I47	7.3	6	1	5
4	R:R:F65	5.85167	6	2	7
5	R:R:H66	5.415	6	2	3
6	R:R:F79	6.2775	4	0	8
7	R:R:M83	5.9175	4	0	9
8	R:R:D87	7.7175	4	0	9
9	R:R:P97	6.5675	4	0	4
10	R:R:T98	5.4225	4	1	6
11	R:R:L101	7.6	4	1	4
12	R:R:C114	5.385	4	6	9
13	R:R:I121	7.79	4	0	6
14	R:R:M129	6.632	5	3	7
15	R:R:W130	4.46571	7	3	5
16	R:R:R139	5.13	4	5	9
17	R:R:Y140	7.296	5	4	8
18	R:R:K145	2.99	4	0	6
19	R:R:Y149	8.216	5	5	8
20	R:R:Y185	8.58125	8	1	7
21	R:R:H186	8.5825	4	0	2
22	R:R:I189	4.74	4	1	4
23	R:R:F190	6.02333	6	0	3
24	R:R:W192	9.575	4	0	4
25	R:R:W197	8.2225	4	8	5
26	R:R:T199	7.085	6	1	3
27	R:R:F203	6.51	5	7	5
28	R:R:I207	6.41	4	0	6
29	R:R:Y212	5.165	4	0	5
30	R:R:Y223	6.7125	4	4	9
31	R:R:H225	8.6975	4	4	5
32	R:R:Y263	10.666	5	2	7
33	R:R:F274	10.388	5	3	9
34	R:R:Y281	6.504	5	1	6
35	R:R:Y284	8.965	4	1	4
36	R:R:F285	9.67	4	1	5
37	R:R:E288	8.704	5	1	3
38	R:R:F300	6.18167	6	1	4
39	R:R:W304	14.0925	4	1	4
40	R:R:N309	10.8325	4	3	9
41	R:R:S310	6.535	4	0	9
42	R:R:Y317	6.25	4	2	9
43	R:R:F324	5.15667	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E43	R:R:F300	34.1007	7	Yes	Yes	1	5	4
2	R:R:E43	R:R:P28	14.3435	3.14	Yes	No	0	5	7
3	R:R:P28	R:R:P296	12.3113	3.9	No	No	0	7	2
4	R:R:N295	R:R:P296	10.2733	4.89	No	No	0	3	2
5	R:R:E43	R:R:Y34	14.1828	10.1	Yes	Yes	1	5	3
6	R:R:F190	R:R:P97	23.2706	4.33	Yes	Yes	0	3	4
7	R:R:I47	R:R:P97	28.6813	5.08	Yes	Yes	0	5	4
8	R:R:I47	R:R:T98	10.7182	4.56	Yes	Yes	1	5	6
9	R:R:F300	R:R:W304	26.1754	15.03	Yes	Yes	1	4	4
10	R:R:F117	R:R:P97	50.2268	11.56	No	Yes	0	5	4
11	R:R:F117	R:R:I121	51.8744	11.3	No	Yes	0	5	6
12	R:R:I121	R:R:V90	99.0987	4.61	Yes	No	0	6	8
13	R:R:S310	R:R:V90	100	8.08	Yes	No	0	9	8
14	R:R:D87	R:R:S310	87.4648	8.83	Yes	Yes	0	9	9
15	R:R:D87	R:R:N58	89.9592	6.73	Yes	No	0	9	9
16	R:R:N58	R:R:P314	85.3981	13.03	No	No	0	9	9
17	R:R:P314	R:R:V61	83.3573	3.53	No	No	0	9	9
18	R:R:F65	R:R:V61	43.1741	3.93	Yes	No	2	7	9
19	R:R:H66	R:R:V61	39.4885	4.15	Yes	No	2	3	9
20	R:R:F65	R:R:Y317	35.6737	7.22	Yes	Yes	2	7	9
21	R:R:H66	R:R:Y317	35.2833	4.36	Yes	Yes	2	3	9
22	R:R:Y263	R:R:Y317	67.2915	4.96	Yes	Yes	2	7	9
23	R:R:T76	R:R:Y263	36.7042	6.24	No	Yes	0	8	7
24	R:R:I135	R:R:T76	21.5196	7.6	No	No	0	9	8
25	R:R:F79	R:R:I135	38.88	6.28	Yes	No	0	8	9
26	R:R:F79	R:R:L158	27.3609	4.87	Yes	No	0	8	7
27	R:R:L158	R:R:Y78	23.6609	7.03	No	No	0	7	4
28	R:R:Y74	R:R:Y78	15.796	3.97	No	No	0	4	4
29	R:R:L267	R:R:Y263	23.2246	10.55	No	Yes	0	8	7
30	R:R:I135	R:R:L267	21.3043	5.71	No	No	0	9	8
31	R:R:R139	R:R:T76	13.7465	6.47	Yes	No	0	9	8
32	R:R:D87	R:R:S128	24.5938	5.89	Yes	No	0	9	9
33	R:R:M83	R:R:S128	24.1116	6.13	Yes	No	0	9	9
34	R:R:D87	R:R:N313	62.983	9.42	Yes	No	0	9	9
35	R:R:M83	R:R:N313	24.6053	5.61	Yes	No	0	9	9
36	R:R:L132	R:R:M83	43.1856	7.07	No	Yes	0	8	9
37	R:R:F274	R:R:N313	39.6607	10.87	Yes	No	0	9	9
38	R:R:F274	R:R:L132	43.0363	7.31	Yes	No	0	9	8
39	R:R:K125	R:R:S310	23.6409	4.59	No	Yes	0	6	9
40	R:R:K125	R:R:N309	23.3021	8.39	No	Yes	0	6	9
41	R:R:F274	R:R:N309	19.8691	24.17	Yes	Yes	3	9	9
42	R:R:C114	R:R:F190	11.3353	8.38	Yes	Yes	0	9	3
43	R:R:H186	R:R:I121	53.1718	10.61	Yes	Yes	0	2	6
44	R:R:H186	R:R:S122	27.9666	5.58	Yes	No	0	2	5
45	R:R:F173	R:R:S122	27.6681	11.89	No	No	0	6	5
46	R:R:F173	R:R:I207	27.8231	7.54	No	Yes	0	6	6
47	R:R:F274	R:R:M129	25.7076	3.73	Yes	Yes	3	9	7
48	R:R:I207	R:R:Y212	27.8145	3.63	Yes	Yes	0	6	5
49	R:R:M129	R:R:Y212	28.9196	5.99	Yes	Yes	0	7	5
50	R:R:L132	R:R:T271	81.856	5.9	No	No	0	8	8
51	R:R:T271	R:R:Y223	86.5721	7.49	No	Yes	0	8	9
52	R:R:T222	R:R:Y223	62.096	4.99	No	Yes	4	7	9
53	R:R:T222	R:R:Y140	59.1481	7.49	No	Yes	4	7	8
54	R:R:T144	R:R:Y140	37.6313	13.73	No	Yes	0	6	8
55	R:R:K145	R:R:T144	19.0109	3	Yes	No	0	6	6
56	R:R:I229	R:R:T144	15.6668	1.52	No	No	0	6	6
57	R:R:F203	R:R:I207	14.866	10.05	Yes	Yes	0	5	6
58	R:R:H186	R:R:Y281	41.2595	14.16	Yes	Yes	0	2	6
59	R:R:I307	R:R:W304	26.2558	15.27	No	Yes	0	6	4
60	R:R:T271	R:R:V219	10.2015	4.76	No	No	0	8	5
61	R:R:F268	R:R:Y223	15.6697	9.28	No	Yes	0	5	9
62	R:R:L277	R:R:N309	13.6891	5.49	No	Yes	0	8	9
63	R:R:P155	R:R:Y74	11.8549	1.39	No	No	0	3	4
64	R:R:F300	R:R:I47	17.2369	3.77	Yes	Yes	1	4	5
65	R:R:H186	R:R:I307	27.0222	3.98	Yes	No	0	2	6
66	R:R:T199	R:R:Y185	10.2015	3.75	Yes	Yes	1	3	7
67	R:R:Y185	R:R:Y281	32.4617	6.95	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6LI2

PDB Summary
PDB	6LI2
Class	A
SubFamily	Orphan
Type	Orphan
SubType	GPR52
Species	Homo Sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.8
Date	2020-02-26
D.O.I.	10.1038/s41586-020-2019-0

Net Summary
I_min	3.53
Number of Linked Nodes	269
Number of Links	307
Number of Hubs	43
Number of Links mediated by Hubs	164
Number of Communities	8
Number of Nodes involved in Communities	64
Number of Links involved in Communities	87

Path Summary
Number Of Nodes in MetaPath	68
Number Of Links MetaPath	67
Number of Shortest Paths	78024
Length Of Smallest Path	3
Average Path Length	14.8337
Length of Longest Path	30
Minimum Path Strength	1.51
Average Path Strength	7.12804
Maximum Path Strength	17.52
Minimum Path Correlation	0.7
Average Path Correlation	0.941605
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	52.7624
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	47.5411
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process	• response to stimulus • response to chemical • response to xenobiotic stimulus • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • G protein-coupled receptor signaling pathway • cellular process • signal transduction • cell communication • behavior • multicellular organismal process • locomotory behavior • response to light stimulus • cellular response to light stimulus • response to radiation • response to abiotic stimulus • cellular response to radiation • cellular response to abiotic stimulus • cellular response to environmental stimulus • phototransduction • detection of light stimulus • detection of external stimulus • response to external stimulus • detection of abiotic stimulus • detection of stimulus • alkane metabolic process • catabolic process • hydrocarbon catabolic process • metabolic process • alkane catabolic process • hydrocarbon metabolic process • cell periphery • cellular anatomical structure • plasma membrane • membrane
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• Rubredoxin-like
SCOP2	Family Identifier	• Rubredoxin-like
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y2T5
Sequence	>6LI2_Chain_R E R H S C P L G F G H Y S V V D V C I F E T V V I V L L T F L I I A G N L T V I F V F H C L H H Y T T S Y F I Q T M A Y A D L F V G V S C L V P T L S L L H Y S T G V H E S L T C Q V F G Y I I S V L K S V S M W C L A C I S V D R Y L A I T K P L S Y N Q L V T P C R L R I C I I L I W I Y S C L I F L P S F F G W G K P G Y H G D I F E W C A T S W L T S A Y F T G F I V C L L Y A P A A F V V C F T Y F H I F K I C R Q H T K Y L M V L F R I T S V F Y M L Q L P Y I I Y F L L E S S R V L D N P T L S F L T T W L A I S N S F C N P V I Y A L S D S T F R L G L R R L S E T M C T S C M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	8HMP	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17	Gs/β1/γ2	2.77	2023-06-21	10.1002/mco2.260
	8HMP (No Gprot)	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17		2.77	2023-06-21	10.1002/mco2.260
	6LI2	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.8	2020-02-26	10.1038/s41586-020-2019-0
	6LI1	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	-	2.9	2020-02-26	10.1038/s41586-020-2019-0
	6LI0	A	Orphan	Orphan	GPR52	Homo sapiens	-	C17	-	2.2	2020-02-26	10.1038/s41586-020-2019-0
	6LI3	A	Orphan	Orphan	GPR52	Homo sapiens	-	-	Gs/β1/γ2	3.32	2020-02-26	10.1038/s41586-020-2019-0
	6LI3 (No Gprot)	A	Orphan	Orphan	GPR52	Homo sapiens	-	-		3.32	2020-02-26	10.1038/s41586-020-2019-0

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LI2.zip

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