psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E23	R:R:S100	7.19	No	No	0	7	4
2	R:R:E23	R:R:S105	8.62	No	No	0	7	4
3	R:R:E191	R:R:R24	19.77	No	No	0	3	6
4	R:R:H25	R:R:S100	6.97	No	No	0	6	4
5	R:R:H25	R:R:L101	11.57	No	Yes	0	6	4
6	R:R:C27	R:R:C40	7.28	No	No	0	6	4
7	R:R:C27	R:R:E43	10.64	No	Yes	0	6	5
8	R:R:P28	R:R:P296	3.9	No	No	0	7	2
9	R:R:E43	R:R:L29	11.93	Yes	No	0	5	5
10	R:R:F31	R:R:G30	4.52	No	No	0	5	5
11	R:R:F31	R:R:T297	3.89	No	No	0	5	1
12	R:R:D38	R:R:Y34	8.05	No	Yes	0	1	3
13	R:R:V39	R:R:Y34	5.05	No	Yes	0	4	3
14	R:R:F42	R:R:Y34	7.22	No	Yes	0	4	3
15	R:R:E43	R:R:Y34	10.1	Yes	Yes	0	5	3
16	R:R:D38	R:R:S35	5.89	No	No	0	1	5
17	R:R:D38	R:R:I41	4.2	No	No	0	1	6
18	R:R:F42	R:R:I41	3.77	No	No	0	4	6
19	R:R:E43	R:R:F300	7	Yes	Yes	0	5	4
20	R:R:L101	R:R:T44	8.84	Yes	No	0	4	6
21	R:R:I47	R:R:P97	5.08	Yes	Yes	0	5	4
22	R:R:I47	R:R:T98	4.56	Yes	Yes	1	5	6
23	R:R:I47	R:R:L101	5.71	Yes	Yes	1	5	4
24	R:R:I189	R:R:I47	5.89	Yes	Yes	1	4	5
25	R:R:F300	R:R:I47	3.77	Yes	Yes	1	4	5
26	R:R:I47	R:R:W304	18.79	Yes	Yes	1	5	4
27	R:R:T98	R:R:V48	4.76	Yes	No	0	6	4
28	R:R:C94	R:R:T51	5.07	No	No	0	7	6
29	R:R:T51	R:R:T98	9.42	No	Yes	1	6	6
30	R:R:F311	R:R:L53	14.61	No	No	0	6	5
31	R:R:I54	R:R:S310	4.64	No	Yes	0	7	9
32	R:R:I55	R:R:L95	4.28	No	No	0	6	7
33	R:R:G57	R:R:P314	4.06	No	No	0	8	9
34	R:R:D87	R:R:N58	6.73	Yes	No	0	9	9
35	R:R:L88	R:R:N58	4.12	No	No	0	6	9
36	R:R:N58	R:R:P314	13.03	No	No	0	9	9
37	R:R:L59	R:R:L88	5.54	No	No	0	5	6
38	R:R:F65	R:R:V61	3.93	Yes	No	2	7	9
39	R:R:H66	R:R:V61	4.15	Yes	No	2	3	9
40	R:R:H66	R:R:I62	6.63	Yes	No	0	3	8
41	R:R:I62	R:R:Y85	8.46	No	No	0	8	6
42	R:R:F65	R:R:V64	10.49	Yes	No	2	7	8
43	R:R:F324	R:R:V64	3.93	Yes	No	2	8	8
44	R:R:F65	R:R:H66	4.53	Yes	Yes	2	7	3
45	R:R:F65	R:R:Y317	7.22	Yes	Yes	2	7	9
46	R:R:F324	R:R:F65	5.36	Yes	Yes	2	8	7
47	R:R:H66	R:R:Q81	9.89	Yes	No	0	3	6
48	R:R:H66	R:R:Y317	4.36	Yes	Yes	2	3	9
49	R:R:H72	R:R:H73	8.36	No	No	2	8	7
50	R:R:H72	R:R:Y263	17.42	No	Yes	2	8	7
51	R:R:H73	R:R:Y263	14.16	No	Yes	2	7	7
52	R:R:Y74	R:R:Y78	3.97	No	No	0	4	4
53	R:R:D138	R:R:T75	11.56	No	No	5	9	6
54	R:R:T75	R:R:Y149	3.75	No	Yes	5	6	8
55	R:R:I135	R:R:T76	7.6	No	No	0	9	8
56	R:R:R139	R:R:T76	6.47	Yes	No	0	9	8
57	R:R:T76	R:R:Y263	6.24	No	Yes	0	8	7
58	R:R:L158	R:R:Y78	7.03	No	No	0	7	4
59	R:R:C134	R:R:F79	11.17	No	Yes	0	6	8
60	R:R:F79	R:R:I135	6.28	Yes	No	0	8	9
61	R:R:F79	R:R:L158	4.87	Yes	No	0	8	7
62	R:R:I80	R:R:Y317	8.46	No	Yes	0	8	9
63	R:R:I162	R:R:T82	9.12	No	No	0	8	9
64	R:R:M83	R:R:S128	6.13	Yes	No	0	9	9
65	R:R:C131	R:R:M83	4.86	No	Yes	0	8	9
66	R:R:L132	R:R:M83	7.07	No	Yes	0	8	9
67	R:R:M83	R:R:N313	5.61	Yes	No	0	9	9
68	R:R:D87	R:R:S128	5.89	Yes	No	0	9	9
69	R:R:D87	R:R:S310	8.83	Yes	Yes	0	9	9
70	R:R:D87	R:R:N313	9.42	Yes	No	0	9	9
71	R:R:F89	R:R:V92	7.87	No	No	0	7	4
72	R:R:I121	R:R:V90	4.61	Yes	No	0	6	8
73	R:R:S310	R:R:V90	8.08	Yes	No	0	9	8
74	R:R:I120	R:R:S93	4.64	No	No	0	5	4
75	R:R:I121	R:R:S93	4.64	Yes	No	0	6	4
76	R:R:P97	R:R:V96	5.3	Yes	No	0	4	7
77	R:R:F117	R:R:P97	11.56	No	Yes	0	5	4
78	R:R:F190	R:R:P97	4.33	Yes	Yes	0	3	4
79	R:R:L99	R:R:Y104	7.03	No	No	0	6	4
80	R:R:F190	R:R:S100	5.28	Yes	No	0	3	4
81	R:R:I189	R:R:L101	4.28	Yes	Yes	1	4	4
82	R:R:E110	R:R:F190	10.49	No	Yes	0	7	3
83	R:R:E110	R:R:E191	6.34	No	No	0	7	3
84	R:R:S111	R:R:W192	12.36	No	Yes	0	3	4
85	R:R:F190	R:R:T113	3.89	Yes	No	0	3	5
86	R:R:C114	R:R:F190	8.38	Yes	Yes	0	9	3
87	R:R:C114	R:R:W192	3.92	Yes	Yes	0	9	4
88	R:R:C114	R:R:C193	7.28	Yes	No	6	9	9
89	R:R:F177	R:R:Q115	8.2	No	No	0	5	6
90	R:R:F117	R:R:I121	11.3	No	Yes	0	5	6
91	R:R:V123	R:R:Y119	6.31	No	No	0	5	6
92	R:R:F177	R:R:Y119	13.41	No	No	0	5	6
93	R:R:H186	R:R:I121	10.61	Yes	Yes	0	2	6
94	R:R:F173	R:R:S122	11.89	No	No	0	6	5
95	R:R:H186	R:R:S122	5.58	Yes	No	0	2	5
96	R:R:F173	R:R:V123	3.93	No	No	0	6	5
97	R:R:K125	R:R:N309	8.39	No	Yes	0	6	9
98	R:R:K125	R:R:S310	4.59	No	Yes	0	6	9
99	R:R:S126	R:R:W130	4.94	No	Yes	3	6	5
100	R:R:L211	R:R:S126	9.01	No	No	3	7	6
101	R:R:I165	R:R:V127	4.61	No	No	0	6	6
102	R:R:V127	R:R:W166	12.26	No	No	0	6	9
103	R:R:M129	R:R:Y212	5.99	Yes	No	0	7	5
104	R:R:A215	R:R:M129	4.83	No	Yes	3	5	7
105	R:R:M129	R:R:Y275	13.17	Yes	No	3	7	5
106	R:R:M129	R:R:Q278	5.44	Yes	No	3	7	8
107	R:R:I165	R:R:W130	4.7	No	Yes	0	6	5
108	R:R:W130	R:R:Y168	6.75	Yes	No	0	5	4
109	R:R:L211	R:R:W130	5.69	No	Yes	3	7	5
110	R:R:A215	R:R:W130	3.89	No	Yes	3	5	5
111	R:R:L132	R:R:T271	5.9	No	No	0	8	8
112	R:R:F274	R:R:L132	7.31	Yes	No	0	9	8
113	R:R:I135	R:R:L267	5.71	No	No	0	9	8
114	R:R:S136	R:R:T222	9.59	No	No	4	8	7
115	R:R:S136	R:R:Y223	5.09	No	Yes	4	8	9
116	R:R:D138	R:R:R139	4.76	No	Yes	5	9	9
117	R:R:D138	R:R:Y149	11.49	No	Yes	5	9	8
118	R:R:A142	R:R:R139	4.15	No	Yes	5	8	9
119	R:R:R139	R:R:Y149	5.14	Yes	Yes	5	9	8
120	R:R:T144	R:R:Y140	13.73	No	Yes	0	6	8
121	R:R:F221	R:R:Y140	6.19	No	Yes	4	4	8
122	R:R:T222	R:R:Y140	7.49	No	Yes	4	7	8
123	R:R:H225	R:R:Y140	5.44	Yes	Yes	4	5	8
124	R:R:A142	R:R:Y149	9.34	No	Yes	5	8	8
125	R:R:I143	R:R:I229	5.89	No	No	0	9	6
126	R:R:K145	R:R:T144	10.51	No	No	0	6	6
127	R:R:V153	R:R:Y149	11.36	No	Yes	0	7	8
128	R:R:I172	R:R:Y168	12.09	No	No	0	5	4
129	R:R:I172	R:R:I207	4.42	No	No	0	5	6
130	R:R:F173	R:R:I207	7.54	No	No	0	6	6
131	R:R:P175	R:R:W180	5.4	No	No	7	6	6
132	R:R:F203	R:R:P175	11.56	Yes	No	7	5	6
133	R:R:P183	R:R:S176	7.13	No	No	8	4	5
134	R:R:S176	R:R:W197	4.94	No	Yes	8	5	5
135	R:R:F203	R:R:W180	4.01	Yes	No	7	5	6
136	R:R:D188	R:R:K182	9.68	No	No	0	4	3
137	R:R:K182	R:R:W197	12.76	No	Yes	0	3	5
138	R:R:K182	R:R:T199	9.01	No	Yes	0	3	3
139	R:R:P183	R:R:W197	6.76	No	Yes	8	4	5
140	R:R:F285	R:R:G184	4.52	Yes	No	0	5	2
141	R:R:D188	R:R:Y185	9.2	No	Yes	0	4	7
142	R:R:T199	R:R:Y185	3.75	Yes	Yes	1	3	7
143	R:R:Y185	R:R:Y281	6.95	Yes	Yes	1	7	6
144	R:R:Y185	R:R:Y284	11.91	Yes	Yes	1	7	4
145	R:R:F285	R:R:Y185	13.41	Yes	Yes	1	5	7
146	R:R:E288	R:R:Y185	14.59	Yes	Yes	1	3	7
147	R:R:S299	R:R:Y185	5.09	No	Yes	1	4	7
148	R:R:T303	R:R:Y185	3.75	No	Yes	1	5	7
149	R:R:H186	R:R:Y281	14.16	Yes	Yes	0	2	6
150	R:R:H186	R:R:I307	3.98	Yes	No	0	2	6
151	R:R:A194	R:R:D188	6.18	No	No	0	4	4
152	R:R:F190	R:R:I189	3.77	Yes	Yes	0	3	4
153	R:R:F300	R:R:I189	5.02	Yes	Yes	1	4	4
154	R:R:E191	R:R:T195	7.06	No	No	0	3	4
155	R:R:S196	R:R:W192	13.59	No	Yes	0	3	4
156	R:R:W192	R:R:W197	8.43	Yes	Yes	0	4	5
157	R:R:L198	R:R:R291	4.86	No	No	0	5	1
158	R:R:F285	R:R:T199	3.89	Yes	Yes	1	5	3
159	R:R:E288	R:R:T199	12.7	Yes	Yes	1	3	3
160	R:R:S289	R:R:T199	7.99	No	Yes	0	4	3
161	R:R:R291	R:R:T199	5.17	No	Yes	1	1	3
162	R:R:F203	R:R:F206	4.29	Yes	No	0	5	5
163	R:R:F203	R:R:I207	10.05	Yes	No	0	5	6
164	R:R:F285	R:R:T204	16.86	Yes	No	0	5	5
165	R:R:S289	R:R:T204	9.59	No	No	0	4	5
166	R:R:F206	R:R:L210	7.31	No	No	0	5	5
167	R:R:V208	R:R:Y212	3.79	No	No	0	4	5
168	R:R:L286	R:R:V208	5.96	No	No	0	5	4
169	R:R:I282	R:R:Y212	7.25	No	No	0	6	5
170	R:R:A215	R:R:Y275	4	No	No	3	5	5
171	R:R:T271	R:R:V219	4.76	No	No	0	8	5
172	R:R:V219	R:R:Y275	12.62	No	No	0	5	5
173	R:R:F221	R:R:H225	12.44	No	Yes	4	4	5
174	R:R:T222	R:R:Y223	4.99	No	Yes	4	7	9
175	R:R:F268	R:R:Y223	9.28	No	Yes	0	5	9
176	R:R:T271	R:R:Y223	7.49	No	Yes	0	8	9
177	R:R:F224	R:R:H225	9.05	No	Yes	0	4	5
178	R:R:H225	R:R:K228	7.86	Yes	No	0	5	4
179	R:R:I226	R:R:L264	4.28	No	No	0	9	7
180	R:R:F227	R:R:L264	8.53	No	No	0	7	7
181	R:R:F227	R:R:F268	11.79	No	No	0	7	5
182	R:R:L267	R:R:Y263	10.55	No	Yes	0	8	7
183	R:R:Y263	R:R:Y317	4.96	Yes	Yes	2	7	9
184	R:R:S320	R:R:V266	8.08	No	No	0	7	8
185	R:R:F268	R:R:S272	7.93	No	No	0	5	5
186	R:R:I316	R:R:R269	5.01	No	No	0	8	7
187	R:R:R269	R:R:S320	5.27	No	No	0	7	7
188	R:R:I316	R:R:V273	4.61	No	No	0	8	7
189	R:R:F274	R:R:Q278	5.86	Yes	No	3	9	8
190	R:R:F274	R:R:N309	24.17	Yes	Yes	3	9	9
191	R:R:F274	R:R:N313	10.87	Yes	No	0	9	9
192	R:R:L277	R:R:S308	6.01	No	No	0	8	6
193	R:R:L277	R:R:N309	5.49	No	Yes	0	8	9
194	R:R:N309	R:R:Q278	5.28	Yes	No	3	9	8
195	R:R:I283	R:R:L279	5.71	No	No	0	5	6
196	R:R:L305	R:R:P280	4.93	No	No	0	7	9
197	R:R:T302	R:R:Y281	3.75	No	Yes	0	5	6
198	R:R:T303	R:R:Y281	4.99	No	Yes	1	5	6
199	R:R:E288	R:R:Y284	8.98	Yes	Yes	1	3	4
200	R:R:S299	R:R:Y284	11.45	No	Yes	1	4	4
201	R:R:L287	R:R:L293	5.54	No	No	0	4	1
202	R:R:E288	R:R:R291	4.65	Yes	No	1	3	1
203	R:R:N295	R:R:P296	4.89	No	No	0	3	2
204	R:R:N295	R:R:T297	7.31	No	No	0	3	1
205	R:R:L298	R:R:N295	15.1	No	No	0	4	3
206	R:R:F300	R:R:W304	15.03	Yes	Yes	1	4	4
207	R:R:T303	R:R:W304	7.28	No	Yes	1	5	4
208	R:R:I307	R:R:W304	15.27	No	Yes	0	6	4
209	R:R:F311	R:R:V315	5.24	No	No	0	6	7
210	R:R:A318	R:R:F324	8.32	No	Yes	0	7	8
211	R:R:D321	R:R:T323	8.67	No	No	0	8	7
212	R:R:R325	R:R:S322	5.27	No	No	0	9	5
213	R:R:F324	R:R:L328	7.31	Yes	No	0	8	7
214	R:R:L326	R:R:R329	7.29	No	No	0	4	5
215	R:R:L326	R:R:R330	9.72	No	No	0	4	5
216	R:R:D321	R:R:F65	3.58	No	Yes	2	8	7
217	R:R:D321	R:R:F324	3.58	No	Yes	2	8	8
218	R:R:G91	R:R:I54	3.53	No	No	0	6	7
219	R:R:P314	R:R:V61	3.53	No	No	0	9	9
220	R:R:L102	R:R:Y104	3.52	No	No	0	4	4
221	R:R:L293	R:R:Y284	3.52	No	Yes	0	1	4
222	R:R:P155	R:R:T154	3.5	No	No	0	3	8
223	R:R:P280	R:R:T302	3.5	No	No	0	9	5
224	R:R:A194	R:R:S26	3.42	No	No	0	4	8
225	R:R:C312	R:R:V273	3.42	No	No	0	5	7
226	R:R:A86	R:R:V127	3.39	No	No	0	8	6
227	R:R:A133	R:R:V218	3.39	No	No	0	7	8
228	R:R:C131	R:R:T82	3.38	No	No	0	8	9
229	R:R:L279	R:R:P280	3.28	No	No	0	6	9
230	R:R:S126	R:R:S169	3.26	No	No	0	6	8
231	R:R:S136	R:R:V137	3.23	No	No	0	8	6
232	R:R:R325	R:R:R329	3.2	No	No	0	9	5
233	R:R:T106	R:R:V108	3.17	No	No	0	4	1
234	R:R:T113	R:R:V108	3.17	No	No	0	5	1
235	R:R:C312	R:R:L277	3.17	No	No	0	5	8
236	R:R:E43	R:R:P28	3.14	Yes	No	0	5	7
237	R:R:I120	R:R:V116	3.07	No	No	0	5	4
238	R:R:I270	R:R:V266	3.07	No	No	0	8	8
239	R:R:F117	R:R:G118	3.01	No	No	0	5	5
240	R:R:L50	R:R:S308	3	No	No	0	6	6
241	R:R:L152	R:R:S148	3	No	No	0	4	5
242	R:R:L88	R:R:V92	2.98	No	No	0	6	4
243	R:R:L124	R:R:V90	2.98	No	No	0	7	8
244	R:R:L112	R:R:V108	2.98	No	No	0	1	1
245	R:R:L141	R:R:V137	2.98	No	No	0	5	6
246	R:R:L287	R:R:V292	2.98	No	No	0	4	3
247	R:R:L95	R:R:T51	2.95	No	No	1	7	6
248	R:R:L95	R:R:T98	2.95	No	Yes	1	7	6
249	R:R:A84	R:R:H66	2.93	No	Yes	0	9	3
250	R:R:W180	R:R:Y202	2.89	No	No	0	6	6
251	R:R:E333	R:R:S332	2.87	No	No	0	4	5
252	R:R:I167	R:R:L171	2.85	No	No	0	4	4
253	R:R:L331	R:R:M335	2.83	No	No	0	6	4
254	R:R:C161	R:R:F79	2.79	No	Yes	0	6	8
255	R:R:H109	R:R:S111	2.79	No	No	0	6	3
256	R:R:P214	R:R:W130	2.7	No	Yes	0	9	5
257	R:R:C170	R:R:Y119	2.69	No	No	0	4	6
258	R:R:A306	R:R:Y281	2.67	No	Yes	0	7	6
259	R:R:H233	R:R:I229	2.65	No	No	0	7	6
260	R:R:N150	R:R:Q151	2.64	No	No	0	4	4
261	R:R:F203	R:R:S200	2.64	Yes	No	0	5	3
262	R:R:F300	R:R:V46	2.62	Yes	No	0	4	4
263	R:R:D294	R:R:E288	2.6	No	Yes	0	3	3
264	R:R:A133	R:R:W130	2.59	No	Yes	0	7	5
265	R:R:R157	R:R:T154	2.59	No	No	0	5	8
266	R:R:F311	R:R:I54	2.51	No	No	0	6	7
267	R:R:F227	R:R:M265	2.49	No	No	0	7	7
268	R:R:H233	R:R:Q232	2.47	No	No	0	7	4
269	R:R:F63	R:R:L59	2.44	No	No	0	4	5
270	R:R:F178	R:R:L174	2.44	No	No	0	5	4
271	R:R:F324	R:R:L319	2.44	Yes	No	0	8	5
272	R:R:Q232	R:R:R231	2.34	No	No	0	4	5
273	R:R:C114	R:R:G187	1.96	Yes	No	6	9	4
274	R:R:C193	R:R:G187	1.96	No	No	6	9	4
275	R:R:A56	R:R:G57	1.95	No	No	0	4	8
276	R:R:A213	R:R:P214	1.87	No	No	0	5	9
277	R:R:G181	R:R:S200	1.86	No	No	0	6	3
278	R:R:K145	R:R:P146	1.67	No	No	0	6	8
279	R:R:C156	R:R:I160	1.64	No	No	0	4	3
280	R:R:L174	R:R:P175	1.64	No	No	0	4	6
281	R:R:C230	R:R:I226	1.64	No	No	0	8	9
282	R:R:S35	R:R:V37	1.62	No	No	0	5	2
283	R:R:S290	R:R:V292	1.62	No	No	0	4	3
284	R:R:C336	R:R:M340	1.62	No	No	0	4	2
285	R:R:V36	R:R:V37	1.6	No	No	0	7	2
286	R:R:V45	R:R:V46	1.6	No	No	0	6	4
287	R:R:G32	R:R:H33	1.59	No	No	0	4	4
288	R:R:T60	R:R:V64	1.59	No	No	0	6	8
289	R:R:C209	R:R:L210	1.59	No	No	0	4	5
290	R:R:K145	R:R:S148	1.53	No	No	0	6	5
291	R:R:I229	R:R:T144	1.52	No	No	0	6	6
292	R:R:L147	R:R:S148	1.5	No	No	0	7	5
293	R:R:L102	R:R:V48	1.49	No	No	0	4	4
294	R:R:I163	R:R:I167	1.47	No	No	0	3	4
295	R:R:L279	R:R:M276	1.41	No	No	0	6	4
296	R:R:C67	R:R:F63	1.4	No	No	0	5	4
297	R:R:H72	R:R:S77	1.39	No	No	0	8	8
298	R:R:P155	R:R:Y74	1.39	No	No	0	3	4
299	R:R:L29	R:R:L301	1.38	No	No	0	5	3
300	R:R:L171	R:R:L174	1.38	No	No	0	4	4
301	R:R:F52	R:R:L53	1.22	No	No	0	5	5
302	R:R:R159	R:R:Y78	1.03	No	No	0	3	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:Y34	7.605	4	0	3
2	R:R:E43	8.562	5	0	5
3	R:R:I47	7.3	6	1	5
4	R:R:F65	5.85167	6	2	7
5	R:R:H66	5.415	6	2	3
6	R:R:F79	6.2775	4	0	8
7	R:R:M83	5.9175	4	0	9
8	R:R:D87	7.7175	4	0	9
9	R:R:P97	6.5675	4	0	4
10	R:R:T98	5.4225	4	1	6
11	R:R:L101	7.6	4	1	4
12	R:R:C114	5.385	4	6	9
13	R:R:I121	7.79	4	0	6
14	R:R:M129	7.3575	4	3	7
15	R:R:W130	4.46571	7	3	5
16	R:R:R139	5.13	4	5	9
17	R:R:Y140	8.2125	4	4	8
18	R:R:Y149	8.216	5	5	8
19	R:R:Y185	8.58125	8	1	7
20	R:R:H186	8.5825	4	0	2
21	R:R:I189	4.74	4	1	4
22	R:R:F190	6.02333	6	0	3
23	R:R:W192	9.575	4	0	4
24	R:R:W197	8.2225	4	8	5
25	R:R:T199	7.085	6	1	3
26	R:R:F203	6.51	5	7	5
27	R:R:Y223	6.7125	4	4	9
28	R:R:H225	8.6975	4	4	5
29	R:R:Y263	10.666	5	2	7
30	R:R:F274	12.0525	4	3	9
31	R:R:Y281	6.504	5	1	6
32	R:R:Y284	8.965	4	1	4
33	R:R:F285	9.67	4	1	5
34	R:R:E288	8.704	5	1	3
35	R:R:F300	6.688	5	1	4
36	R:R:W304	14.0925	4	1	4
37	R:R:N309	10.8325	4	3	9
38	R:R:S310	6.535	4	0	9
39	R:R:Y317	6.25	4	2	9
40	R:R:F324	5.15667	6	2	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E43	R:R:F300	35.387	7	Yes	Yes	0	5	4
2	R:R:E43	R:R:P28	12.0984	3.14	Yes	No	0	5	7
3	R:R:P28	R:R:P296	10.3851	3.9	No	No	0	7	2
4	R:R:E43	R:R:Y34	15.3474	10.1	Yes	Yes	0	5	3
5	R:R:F190	R:R:P97	20.4152	4.33	Yes	Yes	0	3	4
6	R:R:I47	R:R:P97	28.1326	5.08	Yes	Yes	0	5	4
7	R:R:F300	R:R:W304	22.0873	15.03	Yes	Yes	1	4	4
8	R:R:F117	R:R:P97	46.9297	11.56	No	Yes	0	5	4
9	R:R:F117	R:R:I121	48.3343	11.3	No	Yes	0	5	6
10	R:R:I121	R:R:V90	99.398	4.61	Yes	No	0	6	8
11	R:R:S310	R:R:V90	100	8.08	Yes	No	0	9	8
12	R:R:D87	R:R:S310	85.1336	8.83	Yes	Yes	0	9	9
13	R:R:D87	R:R:N58	80.1482	6.73	Yes	No	0	9	9
14	R:R:N58	R:R:P314	76.0965	13.03	No	No	0	9	9
15	R:R:P314	R:R:V61	74.2829	3.53	No	No	0	9	9
16	R:R:F65	R:R:V61	38.4766	3.93	Yes	No	2	7	9
17	R:R:H66	R:R:V61	35.1889	4.15	Yes	No	2	3	9
18	R:R:F65	R:R:Y317	31.7958	7.22	Yes	Yes	2	7	9
19	R:R:H66	R:R:Y317	31.446	4.36	Yes	Yes	2	3	9
20	R:R:Y263	R:R:Y317	59.9774	4.96	Yes	Yes	2	7	9
21	R:R:T76	R:R:Y263	32.7194	6.24	No	Yes	0	8	7
22	R:R:I135	R:R:T76	19.183	7.6	No	No	0	9	8
23	R:R:F79	R:R:I135	34.659	6.28	Yes	No	0	8	9
24	R:R:F79	R:R:L158	24.3871	4.87	Yes	No	0	8	7
25	R:R:L158	R:R:Y78	21.0815	7.03	No	No	0	7	4
26	R:R:Y74	R:R:Y78	14.074	3.97	No	No	0	4	4
27	R:R:L267	R:R:Y263	20.7007	10.55	No	Yes	0	8	7
28	R:R:I135	R:R:L267	18.99	5.71	No	No	0	9	8
29	R:R:R139	R:R:T76	12.2579	6.47	Yes	No	0	9	8
30	R:R:D87	R:R:S128	22.9568	5.89	Yes	No	0	9	9
31	R:R:M83	R:R:S128	22.4552	6.13	Yes	No	0	9	9
32	R:R:D87	R:R:N313	51.3956	9.42	Yes	No	0	9	9
33	R:R:M83	R:R:N313	22.8333	5.61	Yes	No	0	9	9
34	R:R:L132	R:R:M83	40.2387	7.07	No	Yes	0	8	9
35	R:R:F274	R:R:N313	29.3494	10.87	Yes	No	0	9	9
36	R:R:F274	R:R:L132	32.8223	7.31	Yes	No	0	9	8
37	R:R:K125	R:R:S310	23.1266	4.59	No	Yes	0	6	9
38	R:R:K125	R:R:N309	22.6095	8.39	No	Yes	0	6	9
39	R:R:F274	R:R:N309	16.096	24.17	Yes	Yes	3	9	9
40	R:R:C114	R:R:F190	10.079	8.38	Yes	Yes	0	9	3
41	R:R:H186	R:R:I121	55.4472	10.61	Yes	Yes	0	2	6
42	R:R:H186	R:R:S122	18.8434	5.58	Yes	No	0	2	5
43	R:R:F173	R:R:S122	18.0922	11.89	No	No	0	6	5
44	R:R:F173	R:R:I207	15.2677	7.54	No	No	0	6	6
45	R:R:M129	R:R:Q278	10.7144	5.44	Yes	No	3	7	8
46	R:R:L132	R:R:T271	69.5727	5.9	No	No	0	8	8
47	R:R:T271	R:R:Y223	67.8877	7.49	No	Yes	0	8	9
48	R:R:T222	R:R:Y223	41.6124	4.99	No	Yes	4	7	9
49	R:R:T222	R:R:Y140	39.3204	7.49	No	Yes	4	7	8
50	R:R:T144	R:R:Y140	27.1242	13.73	No	Yes	0	6	8
51	R:R:I229	R:R:T144	12.3196	1.52	No	No	0	6	6
52	R:R:K145	R:R:T144	12.474	10.51	No	No	0	6	6
53	R:R:F203	R:R:I207	11.5942	10.05	Yes	No	0	5	6
54	R:R:H186	R:R:Y281	31.4151	14.16	Yes	Yes	0	2	6
55	R:R:I307	R:R:W304	21.596	15.27	No	Yes	0	6	4
56	R:R:F268	R:R:Y223	17.4208	9.28	No	Yes	0	5	9
57	R:R:F227	R:R:F268	12.4662	11.79	No	No	0	7	5
58	R:R:L277	R:R:N309	11.2134	5.49	No	Yes	0	8	9
59	R:R:P155	R:R:Y74	10.5626	1.39	No	No	0	3	4
60	R:R:F300	R:R:I47	17.5109	3.77	Yes	Yes	1	4	5
61	R:R:H186	R:R:I307	22.1362	3.98	Yes	No	0	2	6
62	R:R:A215	R:R:W130	10.1407	3.89	No	Yes	3	5	5
63	R:R:Y185	R:R:Y281	24.809	6.95	Yes	Yes	1	7	6

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

there is no ligand in network 6LI2

PDB Summary
PDB	6LI2
Class	A
SubFamily	Orphan
Type	A orphans
SubType	GPR52
Species	Homo sapiens
Ligand	-
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.8
Date	2020-02-26
D.O.I.	10.1038/s41586-020-2019-0

Net Summary
I_min	3.75
Number of Linked Nodes	270
Number of Links	302
Number of Hubs	40
Number of Links mediated by Hubs	151
Number of Communities	8
Number of Nodes involved in Communities	56
Number of Links involved in Communities	74

Path Summary
Number Of Nodes in MetaPath	64
Number Of Links MetaPath	63
Number of Shortest Paths	73567
Length Of Smallest Path	3
Average Path Length	15.0154
Length of Longest Path	30
Minimum Path Strength	1.51
Average Path Strength	7.18396
Maximum Path Strength	17.52
Minimum Path Correlation	0.7
Average Path Correlation	0.941636
Maximum Path Correlation	1
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	52.9848
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	45.24
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q9Y2T5
Sequence	>6LI2_Chain_R E R H S C P L G F G H Y S V V D V C I F E T V V I V L L T F L I I A G N L T V I F V F H C L H H Y T T S Y F I Q T M A Y A D L F V G V S C L V P T L S L L H Y S T G V H E S L T C Q V F G Y I I S V L K S V S M W C L A C I S V D R Y L A I T K P L S Y N Q L V T P C R L R I C I I L I W I Y S C L I F L P S F F G W G K P G Y H G D I F E W C A T S W L T S A Y F T G F I V C L L Y A P A A F V V C F T Y F H I F K I C R Q H T K Y L M V L F R I T S V F Y M L Q L P Y I I Y F L L E S S R V L D N P T L S F L T T W L A I S N S F C N P V I Y A L S D S T F R L G L R R L S E T M C T S C M Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	6LI0	A	Orphan	A orphans	GPR52	Homo sapiens	-	GTPL9804	-	2.2	2020-02-26	10.1038/s41586-020-2019-0
	6LI1	A	Orphan	A orphans	GPR52	Homo sapiens	-	-	-	2.9	2020-02-26	10.1038/s41586-020-2019-0
	6LI2	A	Orphan	A orphans	GPR52	Homo sapiens	-	-	-	2.8	2020-02-26	10.1038/s41586-020-2019-0
	6LI3	A	Orphan	A orphans	GPR52	Homo sapiens	-	-	Gs/&β;1/&γ;2	3.32	2020-02-26	10.1038/s41586-020-2019-0
	8HMP	A	Orphan	A orphans	GPR52	Homo sapiens	-	PubChem 69921479	Gs/&β;1/&γ;2	2.77	2023-06-21	10.1002/mco2.260

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6LI2.zip

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