psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:G50	R:R:P51	4.06	No	No	0	2	1
2	R:R:G50	R:R:S53	3.71	No	No	0	2	5
3	R:R:N52	R:R:P51	4.89	Yes	No	1	3	1
4	R:R:H219	R:R:P51	4.58	Yes	No	1	3	1
5	R:R:H133	R:R:N52	5.1	Yes	Yes	1	5	3
6	R:R:N52	R:R:S214	4.47	Yes	No	0	3	4
7	R:R:H219	R:R:N52	14.03	Yes	Yes	1	3	3
8	R:R:G221	R:R:N52	3.39	No	Yes	1	4	3
9	R:R:G222	R:R:N52	5.09	No	Yes	0	2	3
10	R:R:D54	R:R:S53	4.42	No	No	0	4	5
11	R:R:H133	R:R:L55	9	Yes	No	1	5	2
12	L:L:Y11	R:R:L55	7.03	Yes	No	1	0	2
13	R:R:D56	R:R:H133	5.04	No	Yes	0	2	5
14	R:R:T59	R:R:V57	3.17	Yes	No	0	2	2
15	R:R:H132	R:R:V57	23.52	No	No	0	5	2
16	R:R:H348	R:R:V57	15.22	Yes	No	0	4	2
17	R:R:K64	R:R:T59	7.51	No	Yes	0	5	2
18	R:R:T59	R:R:Y349	11.24	Yes	No	0	2	1
19	R:R:M352	R:R:T59	6.02	No	Yes	0	4	2
20	R:R:D60	R:R:Y62	4.6	No	No	0	6	3
21	R:R:D60	R:R:S63	10.31	No	No	8	6	2
22	R:R:D60	R:R:Y349	6.9	No	No	8	6	1
23	R:R:I61	R:R:V65	3.07	No	No	0	3	5
24	R:R:S63	R:R:Y349	7.63	No	No	8	2	1
25	R:R:M352	R:R:S63	3.07	No	No	0	4	2
26	R:R:K64	R:R:W130	10.44	No	Yes	0	5	7
27	R:R:H132	R:R:K64	3.93	No	No	0	5	5
28	R:R:I70	R:R:L66	4.28	No	No	0	4	5
29	R:R:V67	R:R:Y71	6.31	No	Yes	1	5	7
30	R:R:I129	R:R:V67	4.61	Yes	No	1	5	5
31	R:R:M352	R:R:V67	10.65	No	No	0	4	5
32	R:R:L125	R:R:T68	5.9	Yes	No	1	6	6
33	R:R:T68	R:R:W130	7.28	No	Yes	1	6	7
34	R:R:L121	R:R:Y71	3.52	Yes	Yes	1	7	7
35	R:R:D124	R:R:Y71	6.9	Yes	Yes	1	7	7
36	R:R:L125	R:R:Y71	7.03	Yes	Yes	1	6	7
37	R:R:I129	R:R:Y71	6.04	Yes	Yes	1	5	7
38	R:R:N355	R:R:Y71	4.65	Yes	Yes	1	6	7
39	R:R:Y359	R:R:Y71	13.9	Yes	Yes	1	7	7
40	R:R:L74	R:R:V360	4.47	No	No	0	7	6
41	R:R:F75	R:R:T79	7.78	No	No	0	6	6
42	R:R:F75	R:R:L121	3.65	No	Yes	0	6	7
43	R:R:G81	R:R:P366	4.06	No	No	0	8	9
44	R:R:A110	R:R:N82	3.13	Yes	Yes	0	9	9
45	R:R:D113	R:R:N82	13.46	No	Yes	0	9	9
46	R:R:L114	R:R:N82	4.12	No	Yes	0	8	9
47	R:R:N82	R:R:P366	9.77	Yes	No	0	9	9
48	R:R:G83	R:R:L114	3.42	No	No	0	4	8
49	R:R:A110	R:R:T85	3.36	Yes	No	0	9	9
50	R:R:P366	R:R:T85	3.5	No	No	0	9	9
51	R:R:A110	R:R:L86	3.15	Yes	No	0	9	7
52	R:R:D103	R:R:L89	5.43	No	No	0	8	7
53	R:R:K92	R:R:S94	4.59	No	No	6	5	4
54	R:R:K92	R:R:Q99	4.07	No	Yes	6	5	7
55	R:R:D103	R:R:K92	8.3	No	No	6	8	5
56	R:R:Q99	R:R:S94	5.78	Yes	No	6	7	4
57	R:R:S100	R:R:S94	3.26	No	No	6	7	4
58	R:R:R101	R:R:S97	6.59	Yes	No	0	6	5
59	R:R:R183	R:R:S97	9.22	No	No	0	4	5
60	R:R:L98	R:R:R101	8.5	No	Yes	0	8	6
61	R:R:A170	R:R:L98	3.15	No	No	0	8	8
62	R:R:L98	R:R:R299	3.64	No	No	0	8	5
63	R:R:D103	R:R:Q99	9.14	No	Yes	6	8	7
64	R:R:S100	R:R:Y104	5.09	No	No	6	7	4
65	R:R:R183	R:R:S100	13.18	No	No	6	4	7
66	R:R:E166	R:R:R101	12.79	Yes	Yes	4	9	6
67	R:R:M181	R:R:R101	11.17	No	Yes	4	6	6
68	R:R:R101	R:R:T186	11.64	Yes	No	4	6	7
69	R:R:L163	R:R:V102	4.47	No	No	0	9	8
70	R:R:R183	R:R:Y104	8.23	No	No	6	4	4
71	R:R:K187	R:R:Y104	17.91	No	No	0	4	4
72	R:R:S162	R:R:Y105	6.36	Yes	Yes	4	7	8
73	R:R:L163	R:R:Y105	5.86	No	Yes	0	9	8
74	R:R:E166	R:R:Y105	11.22	Yes	Yes	4	9	8
75	R:R:T186	R:R:Y105	4.99	No	Yes	4	7	8
76	R:R:I190	R:R:Y105	8.46	No	Yes	0	7	8
77	R:R:L106	R:R:Y369	7.03	No	No	0	8	9
78	R:R:N159	R:R:S108	8.94	No	No	0	8	9
79	R:R:I190	R:R:S108	4.64	No	No	0	7	9
80	R:R:S108	R:R:W194	4.94	No	No	0	9	9
81	R:R:L109	R:R:T156	4.42	No	No	0	9	9
82	R:R:L111	R:R:W194	3.42	No	No	0	6	9
83	R:R:S112	R:R:T156	4.8	No	No	0	8	9
84	R:R:A362	R:R:D113	4.63	No	No	0	9	9
85	R:R:C152	R:R:L115	3.17	No	No	0	7	6
86	R:R:A120	R:R:I116	3.25	No	No	0	6	7
87	R:R:C152	R:R:I116	6.55	No	No	0	7	7
88	R:R:A362	R:R:L117	4.73	No	No	0	9	6
89	R:R:F119	R:R:L118	3.65	No	No	0	5	5
90	R:R:A120	R:R:R149	4.15	No	Yes	0	6	7
91	R:R:L121	R:R:P122	4.93	Yes	No	0	7	9
92	R:R:L121	R:R:Y359	19.93	Yes	Yes	1	7	7
93	R:R:V123	R:R:W135	3.68	No	Yes	1	5	9
94	R:R:F137	R:R:V123	7.87	Yes	No	1	7	5
95	R:R:V123	R:R:Y145	6.31	No	Yes	1	5	6
96	R:R:D124	R:R:F128	7.17	Yes	Yes	1	7	6
97	R:R:D124	R:R:Y145	6.9	Yes	Yes	1	7	6
98	R:R:D124	R:R:Y351	9.2	Yes	Yes	1	7	4
99	R:R:D124	R:R:N355	6.73	Yes	Yes	1	7	6
100	R:R:D124	R:R:Y359	8.05	Yes	Yes	1	7	7
101	R:R:I129	R:R:L125	4.28	Yes	Yes	1	5	6
102	R:R:L125	R:R:W130	3.42	Yes	Yes	1	6	7
103	R:R:N127	R:R:Y126	9.3	No	No	0	5	4
104	R:R:V131	R:R:Y126	12.62	No	No	0	5	4
105	R:R:N127	R:R:W135	11.3	No	Yes	1	5	9
106	R:R:F137	R:R:N127	8.46	Yes	No	1	7	5
107	R:R:F128	R:R:W135	7.02	Yes	Yes	1	6	9
108	R:R:F128	R:R:Y145	8.25	Yes	Yes	1	6	6
109	R:R:F128	R:R:Y146	6.19	Yes	Yes	1	6	5
110	R:R:F128	R:R:Y351	9.28	Yes	Yes	1	6	4
111	L:L:I12	R:R:F128	10.05	No	Yes	1	0	6
112	R:R:I129	R:R:W130	4.7	Yes	Yes	1	5	7
113	L:L:Y11	R:R:H133	3.27	Yes	Yes	1	0	5
114	R:R:G221	R:R:P134	6.09	No	No	0	4	5
115	R:R:F137	R:R:W135	13.03	Yes	Yes	1	7	9
116	R:R:C142	R:R:W135	5.22	No	Yes	1	9	9
117	R:R:L210	R:R:W135	4.56	Yes	Yes	1	5	9
118	R:R:C225	R:R:W135	15.67	No	Yes	1	9	9
119	R:R:A136	R:R:F137	8.32	No	Yes	0	4	7
120	R:R:D139	R:R:K143	5.53	No	No	0	3	7
121	R:R:D139	R:R:L210	6.79	No	Yes	0	3	5
122	R:R:C142	R:R:L210	3.17	No	Yes	1	9	5
123	R:R:C142	R:R:C225	7.28	No	No	1	9	9
124	R:R:Y145	R:R:Y146	11.91	Yes	Yes	1	6	5
125	R:R:R149	R:R:Y145	16.46	Yes	Yes	0	7	6
126	R:R:M204	R:R:Y146	4.79	No	Yes	0	6	5
127	R:R:M208	R:R:Y146	16.76	Yes	Yes	1	5	5
128	L:L:L13	R:R:Y146	9.38	Yes	Yes	1	0	5
129	R:R:F147	R:R:L205	9.74	No	No	0	5	5
130	R:R:C152	R:R:L148	3.17	No	No	0	7	5
131	R:R:N355	R:R:R149	6.03	Yes	Yes	0	6	7
132	R:R:R149	R:R:V358	3.92	Yes	No	0	7	7
133	R:R:R149	R:R:Y359	6.17	Yes	Yes	0	7	7
134	R:R:A201	R:R:E150	3.02	No	Yes	0	7	6
135	R:R:E150	R:R:M204	14.89	Yes	No	0	6	6
136	R:R:E150	R:R:N241	17.09	Yes	Yes	1	6	5
137	R:R:E150	R:R:R328	10.47	Yes	No	1	6	6
138	R:R:N241	R:R:T153	4.39	Yes	No	1	5	7
139	R:R:S245	R:R:T153	6.4	No	No	1	6	7
140	R:R:T153	R:R:W321	4.85	No	Yes	1	7	8
141	R:R:L200	R:R:Y154	11.72	No	No	0	5	6
142	R:R:N241	R:R:Y154	10.47	Yes	No	1	5	6
143	R:R:S245	R:R:Y154	5.09	No	No	1	6	6
144	R:R:A155	R:R:W194	7.78	No	No	0	7	9
145	R:R:A155	R:R:S197	3.42	No	No	0	7	8
146	R:R:F317	R:R:T156	5.19	No	No	0	9	9
147	R:R:A157	R:R:P249	3.74	No	No	0	7	9
148	R:R:I193	R:R:L158	4.28	Yes	No	0	8	7
149	R:R:I193	R:R:N159	4.25	Yes	No	0	8	8
150	R:R:M250	R:R:V160	3.04	Yes	No	0	7	8
151	R:R:V161	S:S:F248	5.24	No	Yes	0	7	5
152	R:R:F189	R:R:S162	6.61	Yes	Yes	4	5	7
153	R:R:I193	R:R:S162	4.64	Yes	Yes	4	8	7
154	R:R:S162	S:S:F248	6.61	Yes	Yes	4	7	5
155	R:R:L163	R:R:L310	4.15	No	No	0	9	8
156	R:R:A253	R:R:S164	3.42	No	No	0	8	9
157	R:R:L256	R:R:S164	6.01	No	No	0	7	9
158	R:R:E166	R:R:M181	10.83	Yes	No	4	9	6
159	R:R:E166	R:R:T186	7.06	Yes	No	4	9	7
160	R:R:C172	R:R:Y168	16.13	Yes	Yes	3	7	8
161	R:R:H173	R:R:Y168	5.44	Yes	Yes	3	6	8
162	R:R:V259	R:R:Y168	3.79	Yes	Yes	3	5	8
163	R:R:Y168	S:S:I255	18.13	Yes	No	0	8	4
164	R:R:Y168	S:S:V259	3.79	Yes	Yes	3	8	5
165	R:R:H173	R:R:L169	3.86	Yes	No	0	6	4
166	R:R:C172	R:R:I171	3.27	Yes	No	3	7	8
167	R:R:I171	R:R:L264	4.28	No	Yes	3	8	8
168	R:R:I171	R:R:L303	7.14	No	No	3	8	8
169	R:R:C172	R:R:H173	4.42	Yes	Yes	3	7	6
170	R:R:C172	R:R:R263	11.14	Yes	No	0	7	5
171	R:R:F175	R:R:K178	3.72	No	No	0	6	4
172	R:R:R185	R:R:S182	14.5	No	No	0	6	7
173	R:R:K188	S:S:Q239	9.49	No	No	0	3	6
174	R:R:F189	R:R:I193	6.28	Yes	Yes	4	5	8
175	R:R:F189	S:S:F243	16.08	Yes	No	0	5	4
176	R:R:F189	S:S:F248	12.86	Yes	Yes	4	5	5
177	R:R:A192	S:S:F243	4.16	No	No	0	3	4
178	R:R:L195	R:R:L199	5.54	No	No	0	3	4
179	R:R:L195	S:S:L240	9.69	No	No	0	3	4
180	R:R:L199	S:S:P203	9.85	No	No	0	4	8
181	R:R:I202	R:R:P203	3.39	No	No	0	4	8
182	R:R:I202	S:S:I202	4.42	No	No	0	4	4
183	R:R:P203	R:R:V237	3.53	No	No	0	8	7
184	R:R:P203	S:S:L199	9.85	No	No	0	8	4
185	R:R:M204	R:R:T207	3.01	No	Yes	0	6	4
186	R:R:M208	R:R:T207	3.01	Yes	Yes	0	5	4
187	R:R:T207	R:R:V229	4.76	Yes	No	0	4	5
188	R:R:T207	R:R:V237	7.93	Yes	No	0	4	7
189	R:R:M208	R:R:P227	8.39	Yes	Yes	1	5	5
190	L:L:L13	R:R:M208	4.24	Yes	Yes	1	0	5
191	R:R:G209	R:R:I228	3.53	No	No	0	3	3
192	R:R:L210	R:R:L223	5.54	Yes	No	0	5	3
193	R:R:L213	R:R:Q211	3.99	No	No	0	2	3
194	R:R:Q211	R:R:T226	5.67	No	No	0	3	3
195	R:R:I228	R:R:Q211	5.49	No	No	0	3	3
196	R:R:N212	R:R:S214	7.45	No	No	0	2	4
197	R:R:G217	R:R:N212	5.09	No	No	0	2	2
198	R:R:L213	R:R:V224	4.47	No	No	0	2	5
199	R:R:D216	R:R:T218	13.01	No	No	0	3	2
200	R:R:H219	R:R:P220	10.68	Yes	No	0	3	3
201	R:R:G221	R:R:H219	3.18	No	Yes	1	4	3
202	R:R:T226	R:R:V224	3.17	No	No	0	3	5
203	L:L:Y11	R:R:V224	7.57	Yes	No	0	0	5
204	R:R:P227	R:R:T226	6.99	Yes	No	0	5	3
205	R:R:L234	R:R:P227	6.57	No	Yes	1	5	5
206	R:R:F331	R:R:P227	5.78	No	Yes	1	3	5
207	L:L:L13	R:R:P227	3.28	Yes	Yes	1	0	5
208	R:R:T233	R:R:V229	7.93	No	No	0	4	5
209	R:R:A232	R:R:D230	3.09	No	No	0	3	4
210	R:R:D230	R:R:T233	8.67	No	No	0	4	4
211	R:R:R235	R:R:T231	6.47	No	No	0	4	1
212	R:R:I238	R:R:L234	7.14	No	No	1	5	5
213	R:R:L234	R:R:V332	4.47	No	Yes	1	5	4
214	R:R:R235	R:R:V332	3.92	No	Yes	1	4	4
215	R:R:R235	R:R:Y333	16.46	No	Yes	1	4	5
216	R:R:I238	R:R:V332	4.61	No	Yes	1	5	4
217	R:R:Q239	R:R:Y333	6.76	No	Yes	0	6	5
218	R:R:Q239	S:S:K188	9.49	No	No	0	6	3
219	R:R:L240	S:S:L195	9.69	No	No	0	4	3
220	R:R:N241	R:R:S245	10.43	Yes	No	1	5	6
221	R:R:H325	R:R:N241	5.1	Yes	Yes	1	7	5
222	R:R:N241	R:R:R328	4.82	Yes	No	1	5	6
223	R:R:H325	R:R:T242	10.95	Yes	No	0	7	5
224	R:R:F243	S:S:F189	15	No	Yes	0	4	5
225	R:R:F243	S:S:A192	4.16	No	No	0	4	3
226	R:R:F246	R:R:L247	4.87	No	No	0	8	5
227	R:R:F246	R:R:L322	3.65	No	No	0	8	6
228	R:R:F246	R:R:H325	13.58	No	Yes	0	8	7
229	R:R:F248	R:R:V252	3.93	Yes	No	0	5	5
230	R:R:F248	S:S:V161	3.93	Yes	No	0	5	7
231	R:R:F248	S:S:S162	5.28	Yes	Yes	5	5	7
232	R:R:F248	S:S:V165	3.93	Yes	No	0	5	6
233	R:R:F248	S:S:F189	12.86	Yes	Yes	5	5	5
234	R:R:M250	R:R:V314	3.04	Yes	No	0	7	8
235	R:R:F317	R:R:M250	9.95	No	Yes	0	9	7
236	R:R:M250	R:R:V318	3.04	Yes	No	0	7	6
237	R:R:I255	S:S:Y168	18.13	No	Yes	0	4	8
238	R:R:I255	S:S:L256	4.28	No	No	0	4	7
239	R:R:N257	R:R:V307	5.91	No	Yes	0	9	7
240	R:R:L310	R:R:N257	4.12	No	No	0	8	9
241	R:R:N257	R:R:R311	4.82	No	No	0	9	5
242	R:R:R262	R:R:V259	3.92	No	Yes	0	5	5
243	R:R:V259	S:S:Y168	3.79	Yes	Yes	3	5	8
244	R:R:V259	S:S:V259	4.81	Yes	Yes	3	5	5
245	R:R:R263	S:S:R262	4.26	No	No	0	5	5
246	R:R:L264	R:R:L303	4.15	Yes	No	3	8	8
247	R:R:L264	R:R:R304	13.36	Yes	No	0	8	6
248	R:R:R304	R:R:T265	5.17	No	No	0	6	5
249	R:R:Q270	R:R:V266	5.73	No	No	0	4	5
250	R:R:V268	R:R:V300	4.81	No	No	0	5	3
251	R:R:I295	R:R:V300	3.07	No	No	0	5	3
252	R:R:E296	R:R:R299	12.79	No	No	0	5	5
253	R:R:G298	R:R:Q301	3.29	No	No	0	3	5
254	R:R:L303	R:R:R299	3.64	No	No	0	8	5
255	R:R:Q301	R:R:R305	3.5	No	No	0	5	8
256	R:R:L308	R:R:R304	3.64	No	No	0	7	6
257	R:R:I315	R:R:R311	6.26	No	No	0	5	5
258	R:R:A312	R:R:L368	3.15	No	No	0	6	8
259	R:R:N365	R:R:V313	5.91	No	No	0	9	8
260	R:R:A316	R:R:I364	3.25	No	No	0	5	6
261	R:R:F317	R:R:W321	14.03	No	Yes	0	9	8
262	R:R:C320	R:R:L357	3.17	No	No	0	8	7
263	R:R:C320	R:R:V360	3.42	No	No	0	8	6
264	R:R:C320	R:R:S361	5.16	No	No	0	8	9
265	R:R:W321	R:R:Y324	10.61	Yes	Yes	1	8	5
266	R:R:H325	R:R:W321	4.23	Yes	Yes	1	7	8
267	R:R:V358	R:R:W321	13.48	No	Yes	1	7	8
268	R:R:S361	R:R:W321	6.18	No	Yes	0	9	8
269	R:R:L322	R:R:P323	3.28	No	No	0	6	9
270	R:R:L357	R:R:P323	3.28	No	No	0	7	9
271	R:R:H325	R:R:Y324	8.71	Yes	Yes	1	7	5
272	R:R:R327	R:R:Y324	4.12	Yes	Yes	1	5	5
273	R:R:R328	R:R:Y324	16.46	No	Yes	1	6	5
274	R:R:V358	R:R:Y324	3.79	No	Yes	1	7	5
275	R:R:F350	R:R:V326	3.93	Yes	No	0	5	5
276	R:R:R327	R:R:Y347	9.26	Yes	Yes	1	5	4
277	R:R:F350	R:R:R327	5.34	Yes	Yes	0	5	5
278	R:R:R327	R:R:Y351	14.4	Yes	Yes	1	5	4
279	R:R:R327	R:R:S354	7.91	Yes	No	0	5	5
280	R:R:N355	R:R:R327	4.82	Yes	Yes	1	6	5
281	R:R:L329	R:R:Y333	3.52	No	Yes	0	5	5
282	R:R:I334	R:R:M330	5.83	No	No	0	3	5
283	R:R:F350	R:R:M330	4.98	Yes	No	0	5	5
284	R:R:F331	R:R:Y347	7.22	No	Yes	1	3	4
285	L:L:L13	R:R:F331	8.53	Yes	No	1	0	3
286	R:R:V332	R:R:Y333	3.79	Yes	Yes	1	4	5
287	R:R:I334	R:R:Q338	4.12	No	No	0	3	1
288	R:R:I334	R:R:W339	12.92	No	Yes	0	3	7
289	R:R:E337	R:R:S335	4.31	No	No	0	2	3
290	R:R:Q338	R:R:S335	8.66	No	No	0	1	3
291	L:L:R9	R:R:D336	5.96	No	No	0	0	2
292	R:R:L343	R:R:W339	7.97	No	Yes	0	2	7
293	R:R:W339	R:R:Y347	4.82	Yes	Yes	1	7	4
294	L:L:R9	R:R:W339	15.99	No	Yes	0	0	7
295	L:L:P10	R:R:W339	17.57	No	Yes	1	0	7
296	R:R:A342	R:R:T340	3.36	No	No	0	3	7
297	R:R:F344	R:R:H348	14.71	No	Yes	0	3	4
298	L:L:R8	R:R:F344	26.72	No	No	0	0	3
299	R:R:F346	R:R:F350	7.5	No	Yes	0	4	5
300	R:R:H348	R:R:Y347	8.71	Yes	Yes	1	4	4
301	L:L:P10	R:R:Y347	15.3	No	Yes	1	0	4
302	L:L:P10	R:R:H348	4.58	No	Yes	1	0	4
303	R:R:N355	R:R:Y351	16.28	Yes	Yes	1	6	4
304	L:L:I12	R:R:Y351	4.84	No	Yes	1	0	4
305	R:R:I364	R:R:L368	5.71	No	No	0	6	8
306	R:R:N365	R:R:Y369	6.98	No	No	0	9	9
307	S:S:G50	S:S:P51	4.06	No	No	0	2	1
308	S:S:G50	S:S:S53	3.71	No	No	0	2	5
309	S:S:N52	S:S:P51	4.89	Yes	No	2	3	1
310	S:S:H219	S:S:P51	6.1	Yes	No	2	3	1
311	S:S:H133	S:S:N52	5.1	Yes	Yes	2	5	3
312	S:S:N52	S:S:S214	4.47	Yes	No	0	3	4
313	S:S:H219	S:S:N52	14.03	Yes	Yes	2	3	3
314	S:S:G221	S:S:N52	3.39	No	Yes	2	4	3
315	S:S:G222	S:S:N52	5.09	No	Yes	0	2	3
316	S:S:D54	S:S:S53	4.42	No	No	0	4	5
317	S:S:H133	S:S:L55	9	Yes	No	2	5	2
318	S:S:L213	S:S:L55	4.15	No	No	0	2	2
319	M:M:Y11	S:S:L55	5.86	Yes	No	2	0	2
320	S:S:D56	S:S:H133	5.04	No	Yes	0	2	5
321	S:S:T59	S:S:V57	3.17	Yes	No	0	2	2
322	S:S:H132	S:S:V57	23.52	No	No	0	5	2
323	S:S:H348	S:S:V57	15.22	Yes	No	0	4	2
324	S:S:K64	S:S:T59	7.51	No	Yes	0	5	2
325	S:S:T59	S:S:Y349	12.48	Yes	No	0	2	1
326	S:S:M352	S:S:T59	7.53	No	Yes	0	4	2
327	S:S:D60	S:S:Y62	4.6	No	No	0	6	3
328	S:S:D60	S:S:S63	10.31	No	No	9	6	2
329	S:S:D60	S:S:Y349	6.9	No	No	9	6	1
330	S:S:I61	S:S:V65	3.07	No	No	0	3	5
331	S:S:S63	S:S:Y349	7.63	No	No	9	2	1
332	S:S:M352	S:S:S63	3.07	No	No	0	4	2
333	S:S:K64	S:S:W130	10.44	No	Yes	0	5	7
334	S:S:H132	S:S:K64	3.93	No	No	0	5	5
335	S:S:I70	S:S:L66	4.28	No	No	0	4	5
336	S:S:V67	S:S:Y71	6.31	No	Yes	2	5	7
337	S:S:I129	S:S:V67	4.61	Yes	No	2	5	5
338	S:S:M352	S:S:V67	10.65	No	No	0	4	5
339	S:S:L125	S:S:T68	5.9	Yes	No	2	6	6
340	S:S:T68	S:S:W130	7.28	No	Yes	2	6	7
341	S:S:L121	S:S:Y71	3.52	Yes	Yes	2	7	7
342	S:S:D124	S:S:Y71	6.9	Yes	Yes	2	7	7
343	S:S:L125	S:S:Y71	7.03	Yes	Yes	2	6	7
344	S:S:I129	S:S:Y71	6.04	Yes	Yes	2	5	7
345	S:S:N355	S:S:Y71	4.65	Yes	Yes	2	6	7
346	S:S:Y359	S:S:Y71	13.9	Yes	Yes	2	7	7
347	S:S:F75	S:S:T79	7.78	No	No	0	6	6
348	S:S:F75	S:S:L121	3.65	No	Yes	0	6	7
349	S:S:G81	S:S:P366	4.06	No	No	0	8	9
350	S:S:A110	S:S:N82	3.13	Yes	Yes	0	9	9
351	S:S:D113	S:S:N82	13.46	No	Yes	0	9	9
352	S:S:L114	S:S:N82	4.12	No	Yes	0	8	9
353	S:S:N82	S:S:P366	9.77	Yes	No	0	9	9
354	S:S:G83	S:S:L114	3.42	No	No	0	4	8
355	S:S:A110	S:S:T85	3.36	Yes	No	0	9	9
356	S:S:P366	S:S:T85	3.5	No	No	0	9	9
357	S:S:A110	S:S:L86	3.15	Yes	No	0	9	7
358	S:S:D103	S:S:L89	5.43	No	No	0	8	7
359	S:S:K92	S:S:S94	4.59	No	No	7	5	4
360	S:S:K92	S:S:Q99	4.07	No	Yes	7	5	7
361	S:S:D103	S:S:K92	8.3	No	No	7	8	5
362	S:S:Q99	S:S:S94	5.78	Yes	No	7	7	4
363	S:S:S100	S:S:S94	3.26	No	No	7	7	4
364	S:S:R101	S:S:S97	6.59	Yes	No	0	6	5
365	S:S:R183	S:S:S97	7.91	No	No	0	4	5
366	S:S:L98	S:S:R101	8.5	No	Yes	0	8	6
367	S:S:A170	S:S:L98	3.15	No	No	0	8	8
368	S:S:L98	S:S:R299	4.86	No	No	0	8	5
369	S:S:D103	S:S:Q99	9.14	No	Yes	7	8	7
370	S:S:S100	S:S:Y104	5.09	No	No	7	7	4
371	S:S:R183	S:S:S100	13.18	No	No	7	4	7
372	S:S:E166	S:S:R101	12.79	Yes	Yes	5	9	6
373	S:S:M181	S:S:R101	12.41	No	Yes	5	6	6
374	S:S:R101	S:S:T186	11.64	Yes	No	5	6	7
375	S:S:L163	S:S:V102	4.47	No	No	0	9	8
376	S:S:R183	S:S:Y104	8.23	No	No	7	4	4
377	S:S:K187	S:S:Y104	17.91	No	No	0	4	4
378	S:S:N159	S:S:Y105	3.49	No	Yes	0	8	8
379	S:S:S162	S:S:Y105	6.36	Yes	Yes	5	7	8
380	S:S:L163	S:S:Y105	5.86	No	Yes	0	9	8
381	S:S:E166	S:S:Y105	11.22	Yes	Yes	5	9	8
382	S:S:T186	S:S:Y105	4.99	No	Yes	5	7	8
383	S:S:I190	S:S:Y105	8.46	No	Yes	0	7	8
384	S:S:L106	S:S:Y369	7.03	No	No	0	8	9
385	S:S:N159	S:S:S108	8.94	No	No	0	8	9
386	S:S:I190	S:S:S108	4.64	No	No	0	7	9
387	S:S:S108	S:S:W194	4.94	No	No	0	9	9
388	S:S:L109	S:S:T156	4.42	No	No	0	9	9
389	S:S:L111	S:S:L115	4.15	No	No	0	6	6
390	S:S:L111	S:S:W194	4.56	No	No	0	6	9
391	S:S:S112	S:S:T156	4.8	No	No	0	8	9
392	S:S:A362	S:S:D113	4.63	No	No	0	9	9
393	S:S:C152	S:S:L115	3.17	No	No	0	7	6
394	S:S:A120	S:S:I116	3.25	No	No	0	6	7
395	S:S:C152	S:S:I116	6.55	No	No	0	7	7
396	S:S:A362	S:S:L117	4.73	No	No	0	9	6
397	S:S:F119	S:S:L118	4.87	No	No	0	5	5
398	S:S:A120	S:S:R149	4.15	No	Yes	0	6	7
399	S:S:L121	S:S:P122	4.93	Yes	No	0	7	9
400	S:S:L121	S:S:Y359	19.93	Yes	Yes	2	7	7
401	S:S:V123	S:S:W135	3.68	No	Yes	2	5	9
402	S:S:F137	S:S:V123	6.55	Yes	No	2	7	5
403	S:S:V123	S:S:Y145	6.31	No	Yes	2	5	6
404	S:S:D124	S:S:F128	7.17	Yes	Yes	2	7	6
405	S:S:D124	S:S:Y145	6.9	Yes	Yes	2	7	6
406	S:S:D124	S:S:Y351	9.2	Yes	Yes	2	7	4
407	S:S:D124	S:S:N355	6.73	Yes	Yes	2	7	6
408	S:S:D124	S:S:Y359	8.05	Yes	Yes	2	7	7
409	S:S:I129	S:S:L125	4.28	Yes	Yes	2	5	6
410	S:S:L125	S:S:W130	3.42	Yes	Yes	2	6	7
411	S:S:N127	S:S:Y126	9.3	No	No	0	5	4
412	S:S:V131	S:S:Y126	12.62	No	No	0	5	4
413	S:S:N127	S:S:W135	11.3	No	Yes	2	5	9
414	S:S:F137	S:S:N127	8.46	Yes	No	2	7	5
415	S:S:F128	S:S:W135	7.02	Yes	Yes	2	6	9
416	S:S:F128	S:S:Y145	8.25	Yes	Yes	2	6	6
417	S:S:F128	S:S:Y146	6.19	Yes	Yes	2	6	5
418	S:S:F128	S:S:Y351	9.28	Yes	Yes	2	6	4
419	M:M:I12	S:S:F128	11.3	No	Yes	2	0	6
420	S:S:I129	S:S:W130	4.7	Yes	Yes	2	5	7
421	M:M:Y11	S:S:H132	3.27	Yes	No	0	0	5
422	M:M:Y11	S:S:H133	3.27	Yes	Yes	2	0	5
423	S:S:G221	S:S:P134	6.09	No	No	0	4	5
424	S:S:F137	S:S:W135	13.03	Yes	Yes	2	7	9
425	S:S:C142	S:S:W135	5.22	No	Yes	2	9	9
426	S:S:L210	S:S:W135	3.42	Yes	Yes	2	5	9
427	S:S:C225	S:S:W135	15.67	No	Yes	2	9	9
428	S:S:A136	S:S:F137	5.55	No	Yes	0	4	7
429	S:S:D139	S:S:K143	5.53	No	No	0	3	7
430	S:S:D139	S:S:L210	6.79	No	Yes	0	3	5
431	S:S:C142	S:S:L210	3.17	No	Yes	2	9	5
432	S:S:C142	S:S:C225	7.28	No	No	2	9	9
433	S:S:Y145	S:S:Y146	9.93	Yes	Yes	2	6	5
434	S:S:R149	S:S:Y145	16.46	Yes	Yes	0	7	6
435	S:S:M204	S:S:Y146	4.79	No	Yes	0	6	5
436	S:S:M208	S:S:Y146	16.76	Yes	Yes	2	5	5
437	M:M:L13	S:S:Y146	8.21	Yes	Yes	2	0	5
438	S:S:F147	S:S:L205	10.96	No	No	0	5	5
439	S:S:C152	S:S:L148	3.17	No	No	0	7	5
440	S:S:N355	S:S:R149	6.03	Yes	Yes	0	6	7
441	S:S:R149	S:S:V358	3.92	Yes	No	0	7	7
442	S:S:R149	S:S:Y359	6.17	Yes	Yes	0	7	7
443	S:S:A201	S:S:E150	3.02	No	Yes	0	7	6
444	S:S:E150	S:S:M204	14.89	Yes	No	0	6	6
445	S:S:E150	S:S:N241	17.09	Yes	Yes	2	6	5
446	S:S:E150	S:S:R328	10.47	Yes	No	2	6	6
447	S:S:N241	S:S:T153	4.39	Yes	No	2	5	7
448	S:S:S245	S:S:T153	6.4	No	No	2	6	7
449	S:S:T153	S:S:W321	4.85	No	Yes	2	7	8
450	S:S:L200	S:S:Y154	11.72	No	No	0	5	6
451	S:S:N241	S:S:Y154	10.47	Yes	No	2	5	6
452	S:S:S245	S:S:Y154	5.09	No	No	2	6	6
453	S:S:A155	S:S:W194	7.78	No	No	0	7	9
454	S:S:A155	S:S:S197	3.42	No	No	0	7	8
455	S:S:F317	S:S:T156	3.89	No	No	0	9	9
456	S:S:A157	S:S:P249	3.74	No	No	0	7	9
457	S:S:I193	S:S:L158	4.28	Yes	No	0	8	7
458	S:S:I193	S:S:N159	4.25	Yes	No	0	8	8
459	S:S:M250	S:S:V160	3.04	No	No	0	7	8
460	S:S:V161	S:S:V252	3.21	No	No	0	7	5
461	S:S:F189	S:S:S162	6.61	Yes	Yes	5	5	7
462	S:S:I193	S:S:S162	4.64	Yes	Yes	5	8	7
463	S:S:L163	S:S:L310	4.15	No	No	0	9	8
464	S:S:A253	S:S:S164	3.42	No	No	0	8	9
465	S:S:L256	S:S:S164	6.01	No	No	0	7	9
466	S:S:E166	S:S:M181	10.83	Yes	No	5	9	6
467	S:S:E166	S:S:T186	7.06	Yes	No	5	9	7
468	S:S:C172	S:S:Y168	16.13	Yes	Yes	3	7	8
469	S:S:H173	S:S:Y168	5.44	Yes	Yes	3	6	8
470	S:S:V259	S:S:Y168	3.79	Yes	Yes	3	5	8
471	S:S:H173	S:S:L169	3.86	Yes	No	0	6	4
472	S:S:C172	S:S:I171	3.27	Yes	No	3	7	8
473	S:S:I171	S:S:L264	4.28	No	Yes	3	8	8
474	S:S:I171	S:S:L303	7.14	No	No	3	8	8
475	S:S:C172	S:S:H173	4.42	Yes	Yes	3	7	6
476	S:S:C172	S:S:R263	11.14	Yes	No	0	7	5
477	S:S:F175	S:S:K178	8.69	No	No	0	6	4
478	S:S:R185	S:S:S182	14.5	No	No	0	6	7
479	S:S:F189	S:S:I193	6.28	Yes	Yes	5	5	8
480	S:S:L195	S:S:L199	5.54	No	No	0	3	4
481	S:S:I202	S:S:P203	3.39	No	No	0	4	8
482	S:S:P203	S:S:V237	3.53	No	No	0	8	7
483	S:S:M204	S:S:T207	3.01	No	Yes	0	6	4
484	S:S:M208	S:S:T207	3.01	Yes	Yes	0	5	4
485	S:S:T207	S:S:V229	4.76	Yes	No	0	4	5
486	S:S:T207	S:S:V237	6.35	Yes	No	0	4	7
487	S:S:M208	S:S:P227	8.39	Yes	Yes	2	5	5
488	M:M:L13	S:S:M208	4.24	Yes	Yes	2	0	5
489	S:S:G209	S:S:I228	3.53	No	No	0	3	3
490	S:S:L210	S:S:L223	5.54	Yes	No	0	5	3
491	S:S:L213	S:S:Q211	3.99	No	No	0	2	3
492	S:S:I228	S:S:Q211	4.12	No	No	0	3	3
493	S:S:N212	S:S:S214	7.45	No	No	0	2	4
494	S:S:G217	S:S:N212	5.09	No	No	0	2	2
495	S:S:L213	S:S:V224	4.47	No	No	0	2	5
496	S:S:D216	S:S:T218	14.45	No	No	0	3	2
497	S:S:H219	S:S:P220	6.1	Yes	No	0	3	3
498	S:S:G221	S:S:H219	3.18	No	Yes	2	4	3
499	S:S:T226	S:S:V224	3.17	No	No	0	3	5
500	M:M:Y11	S:S:V224	8.83	Yes	No	0	0	5
501	S:S:P227	S:S:T226	6.99	Yes	No	0	5	3
502	S:S:L234	S:S:P227	6.57	No	Yes	2	5	5
503	S:S:F331	S:S:P227	5.78	No	Yes	2	3	5
504	M:M:L13	S:S:P227	3.28	Yes	Yes	2	0	5
505	S:S:T233	S:S:V229	7.93	No	No	0	4	5
506	S:S:A232	S:S:D230	3.09	No	No	0	3	4
507	S:S:D230	S:S:T233	7.23	No	No	0	4	4
508	S:S:R235	S:S:T231	6.47	No	No	0	4	1
509	S:S:I238	S:S:L234	7.14	No	No	2	5	5
510	S:S:L234	S:S:V332	4.47	No	Yes	2	5	4
511	S:S:R235	S:S:V332	3.92	No	Yes	2	4	4
512	S:S:R235	S:S:Y333	15.43	No	Yes	2	4	5
513	S:S:I238	S:S:V332	4.61	No	Yes	2	5	4
514	S:S:Q239	S:S:Y333	6.76	No	Yes	0	6	5
515	S:S:N241	S:S:S245	10.43	Yes	No	2	5	6
516	S:S:H325	S:S:N241	5.1	Yes	Yes	2	7	5
517	S:S:N241	S:S:R328	4.82	Yes	No	2	5	6
518	S:S:H325	S:S:T242	12.32	Yes	No	0	7	5
519	S:S:F246	S:S:L247	4.87	No	No	0	8	5
520	S:S:F246	S:S:L322	3.65	No	No	0	8	6
521	S:S:F246	S:S:H325	12.44	No	Yes	0	8	7
522	S:S:F248	S:S:V252	3.93	Yes	No	0	5	5
523	S:S:F317	S:S:M250	9.95	No	No	0	9	7
524	S:S:M250	S:S:V318	3.04	No	No	0	7	6
525	S:S:N257	S:S:V307	5.91	No	Yes	0	9	7
526	S:S:L310	S:S:N257	4.12	No	No	0	8	9
527	S:S:N257	S:S:R311	4.82	No	No	0	9	5
528	S:S:R262	S:S:V259	3.92	No	Yes	0	5	5
529	S:S:M267	S:S:R263	8.69	No	No	0	6	5
530	S:S:L264	S:S:L303	4.15	Yes	No	3	8	8
531	S:S:L264	S:S:R304	13.36	Yes	No	0	8	6
532	S:S:R304	S:S:T265	5.17	No	No	0	6	5
533	S:S:Q270	S:S:V266	5.73	No	No	0	4	5
534	S:S:V268	S:S:V300	4.81	No	No	0	5	3
535	S:S:I295	S:S:V300	3.07	No	No	0	5	3
536	S:S:E296	S:S:R299	11.63	No	No	0	5	5
537	S:S:G298	S:S:Q301	3.29	No	No	0	3	5
538	S:S:Q301	S:S:R305	3.5	No	No	0	5	8
539	S:S:L308	S:S:R304	3.64	No	No	0	7	6
540	S:S:I315	S:S:R311	6.26	No	No	0	5	5
541	S:S:A312	S:S:L368	3.15	No	No	0	6	8
542	S:S:N365	S:S:V313	8.87	No	No	0	9	8
543	S:S:A316	S:S:I364	3.25	No	No	0	5	6
544	S:S:F317	S:S:W321	14.03	No	Yes	0	9	8
545	S:S:C320	S:S:V360	3.42	No	No	0	8	6
546	S:S:C320	S:S:S361	5.16	No	No	0	8	9
547	S:S:W321	S:S:Y324	10.61	Yes	Yes	2	8	5
548	S:S:H325	S:S:W321	4.23	Yes	Yes	2	7	8
549	S:S:V358	S:S:W321	13.48	No	Yes	2	7	8
550	S:S:S361	S:S:W321	6.18	No	Yes	0	9	8
551	S:S:L322	S:S:P323	3.28	No	No	0	6	9
552	S:S:L357	S:S:P323	3.28	No	No	0	7	9
553	S:S:H325	S:S:Y324	8.71	Yes	Yes	2	7	5
554	S:S:R327	S:S:Y324	4.12	Yes	Yes	2	5	5
555	S:S:R328	S:S:Y324	16.46	No	Yes	2	6	5
556	S:S:V358	S:S:Y324	3.79	No	Yes	2	7	5
557	S:S:F350	S:S:V326	3.93	Yes	No	0	5	5
558	S:S:R327	S:S:Y347	9.26	Yes	Yes	2	5	4
559	S:S:F350	S:S:R327	6.41	Yes	Yes	0	5	5
560	S:S:R327	S:S:Y351	14.4	Yes	Yes	2	5	4
561	S:S:R327	S:S:S354	7.91	Yes	No	0	5	5
562	S:S:N355	S:S:R327	4.82	Yes	Yes	2	6	5
563	S:S:L329	S:S:Y333	3.52	No	Yes	0	5	5
564	S:S:I334	S:S:M330	5.83	No	No	0	3	5
565	S:S:F350	S:S:M330	4.98	Yes	No	0	5	5
566	S:S:F331	S:S:Y347	7.22	No	Yes	2	3	4
567	M:M:L13	S:S:F331	10.96	Yes	No	2	0	3
568	S:S:V332	S:S:Y333	3.79	Yes	Yes	2	4	5
569	S:S:I334	S:S:Q338	4.12	No	No	0	3	1
570	S:S:I334	S:S:W339	12.92	No	Yes	0	3	7
571	S:S:E337	S:S:S335	4.31	No	No	0	2	3
572	S:S:Q338	S:S:S335	8.66	No	No	0	1	3
573	M:M:R9	S:S:D336	9.53	No	No	0	0	2
574	S:S:L343	S:S:W339	7.97	No	Yes	0	2	7
575	S:S:W339	S:S:Y347	4.82	Yes	Yes	2	7	4
576	M:M:R9	S:S:W339	15.99	No	Yes	0	0	7
577	M:M:P10	S:S:W339	14.86	No	Yes	2	0	7
578	S:S:A342	S:S:T340	3.36	No	No	0	3	7
579	M:M:R8	S:S:T341	3.88	No	No	0	0	4
580	S:S:F344	S:S:H348	14.71	No	Yes	0	3	4
581	M:M:R8	S:S:F344	21.38	No	No	0	0	3
582	S:S:F346	S:S:F350	6.43	No	Yes	0	4	5
583	S:S:H348	S:S:Y347	8.71	Yes	Yes	2	4	4
584	M:M:P10	S:S:Y347	15.3	No	Yes	2	0	4
585	M:M:P10	S:S:H348	4.58	No	Yes	2	0	4
586	S:S:N355	S:S:Y351	16.28	Yes	Yes	2	6	4
587	M:M:I12	S:S:Y351	4.84	No	Yes	2	0	4
588	S:S:I364	S:S:L368	5.71	No	No	0	6	8
589	S:S:N365	S:S:Y369	6.98	No	No	0	9	9
590	L:L:I12	L:L:Y11	6.04	No	Yes	1	0	0
591	M:M:I12	M:M:Y11	8.46	No	Yes	2	0	0
592	R:R:L106	R:R:V102	2.98	No	No	0	8	8
593	R:R:L169	R:R:V165	2.98	No	No	0	4	6
594	R:R:L256	R:R:V165	2.98	No	No	0	7	6
595	R:R:V165	S:S:L251	2.98	No	No	0	6	3
596	R:R:L251	S:S:V165	2.98	No	No	0	3	6
597	R:R:L256	R:R:V252	2.98	No	No	0	7	5
598	R:R:L264	R:R:V268	2.98	Yes	No	0	8	5
599	S:S:L74	S:S:V360	2.98	No	No	0	7	6
600	S:S:L106	S:S:V102	2.98	No	No	0	8	8
601	S:S:L264	S:S:V268	2.98	Yes	No	0	8	5
602	R:R:L72	R:R:T68	2.95	No	No	0	3	6
603	R:R:L117	R:R:T79	2.95	No	No	0	6	6
604	R:R:L118	R:R:T79	2.95	No	No	0	5	6
605	R:R:L89	R:R:T85	2.95	No	No	0	7	9
606	R:R:L180	R:R:T179	2.95	No	No	0	5	4
607	S:S:L72	S:S:T68	2.95	No	No	0	3	6
608	S:S:L117	S:S:T79	2.95	No	No	0	6	6
609	S:S:L118	S:S:T79	2.95	No	No	0	5	6
610	S:S:L89	S:S:T85	2.95	No	No	0	7	9
611	S:S:L180	S:S:T179	2.95	No	No	0	5	4
612	R:R:F248	R:R:P249	2.89	Yes	No	0	5	9
613	S:S:F248	S:S:P249	2.89	Yes	No	0	5	9
614	R:R:I70	R:R:L74	2.85	No	No	0	4	7
615	S:S:I70	S:S:L74	2.85	No	No	0	4	7
616	R:R:K176	R:R:L180	2.82	No	No	0	5	5
617	S:S:K176	S:S:L180	2.82	No	No	0	5	5
618	R:R:G138	R:R:W135	2.81	No	Yes	0	8	9
619	S:S:G138	S:S:W135	2.81	No	Yes	0	8	9
620	R:R:A201	R:R:F147	2.77	No	No	0	7	5
621	R:R:L353	R:R:L357	2.77	No	No	0	5	7
622	S:S:A201	S:S:F147	2.77	No	No	0	7	5
623	S:S:L353	S:S:L357	2.77	No	No	0	5	7
624	S:S:M267	S:S:Q270	2.72	No	No	0	6	4
625	R:R:H173	R:R:K176	2.62	Yes	No	0	6	5
626	S:S:H173	S:S:K176	2.62	Yes	No	0	6	5
627	L:L:R8	R:R:T341	2.59	No	No	0	0	4
628	S:S:R262	S:S:T258	2.59	No	No	0	5	1
629	R:R:V309	R:R:Y369	2.52	No	No	0	8	9
630	S:S:V309	S:S:Y369	2.52	No	No	0	8	9
631	R:R:F206	R:R:I202	2.51	No	No	0	4	4
632	S:S:F206	S:S:I202	2.51	No	No	0	4	4
633	R:R:M244	S:S:F189	2.49	No	Yes	0	4	5
634	S:S:K93	S:S:R91	2.48	No	No	0	7	6
635	R:R:V65	R:R:W130	2.45	No	Yes	0	5	7
636	S:S:D345	S:S:F344	2.39	No	No	0	3	3
637	S:S:I61	S:S:W130	2.35	No	Yes	0	3	7
638	R:R:R185	S:S:F243	2.14	No	No	0	6	4
639	R:R:F243	S:S:R185	2.14	No	No	0	4	6
640	L:L:G6	L:L:G7	2.11	No	No	0	0	0
641	M:M:G6	M:M:G7	2.11	No	No	0	0	0
642	R:R:G298	R:R:P297	2.03	No	No	0	3	3
643	S:S:G298	S:S:P297	2.03	No	No	0	3	3
644	R:R:A363	R:R:G78	1.95	No	No	0	6	8
645	R:R:A110	R:R:G107	1.95	Yes	No	0	9	5
646	S:S:A363	S:S:G78	1.95	No	No	0	6	8
647	S:S:A110	S:S:G107	1.95	Yes	No	0	9	5
648	R:R:G81	R:R:V80	1.84	No	No	0	8	4
649	S:S:G81	S:S:V80	1.84	No	No	0	8	4
650	R:R:A151	R:R:A201	1.79	No	No	0	5	7
651	S:S:A151	S:S:A201	1.79	No	No	0	5	7
652	R:R:G144	R:R:K143	1.74	No	No	0	4	7
653	S:S:G144	S:S:K143	1.74	No	No	0	4	7
654	R:R:G78	R:R:L117	1.71	No	No	0	8	6
655	R:R:G306	R:R:L167	1.71	No	No	0	8	9
656	S:S:G78	S:S:L117	1.71	No	No	0	8	6
657	S:S:G306	S:S:L167	1.71	No	No	0	8	9
658	R:R:A260	R:R:V307	1.7	No	Yes	0	8	7
659	R:R:A261	R:R:V307	1.7	No	Yes	0	6	7
660	S:S:A363	S:S:V77	1.7	No	No	0	6	5
661	S:S:A253	S:S:V314	1.7	No	No	0	8	8
662	S:S:A260	S:S:V307	1.7	No	Yes	0	8	7
663	S:S:A261	S:S:V307	1.7	No	Yes	0	6	7
664	R:R:D216	R:R:G217	1.68	No	No	0	3	2
665	L:L:G7	R:R:D336	1.68	No	No	0	0	2
666	S:S:D216	S:S:G217	1.68	No	No	0	3	2
667	M:M:G7	S:S:D336	1.68	No	No	0	0	2
668	R:R:S182	R:R:S184	1.63	No	No	0	7	4
669	S:S:S182	S:S:S184	1.63	No	No	0	7	4
670	R:R:A356	R:R:I70	1.62	No	No	0	5	4
671	R:R:S254	R:R:V314	1.62	No	No	0	5	8
672	S:S:A356	S:S:I70	1.62	No	No	0	5	4
673	S:S:S254	S:S:V314	1.62	No	No	0	5	8
674	R:R:A196	S:S:M244	1.61	Yes	No	0	5	4
675	R:R:M244	S:S:A196	1.61	No	No	0	4	5
676	R:R:V76	R:R:V77	1.6	No	No	0	5	5
677	R:R:V80	R:R:V84	1.6	No	No	0	4	6
678	S:S:V76	S:S:V77	1.6	No	No	0	5	5
679	S:S:V80	S:S:V84	1.6	No	No	0	4	6
680	R:R:T88	R:R:V84	1.59	No	No	0	7	6
681	S:S:T88	S:S:V84	1.59	No	No	0	7	6
682	R:R:A196	R:R:L158	1.58	Yes	No	0	5	7
683	R:R:A177	R:R:L169	1.58	No	No	0	6	4
684	R:R:A196	S:S:L200	1.58	Yes	No	0	5	5
685	R:R:A196	S:S:L240	1.58	Yes	No	0	5	4
686	S:S:A177	S:S:L169	1.58	No	No	0	6	4
687	R:R:E296	R:R:P297	1.57	No	No	0	5	3
688	S:S:E296	S:S:P297	1.57	No	No	0	5	3
689	R:R:I367	R:R:V77	1.54	No	No	0	7	5
690	R:R:I315	R:R:V319	1.54	No	No	0	5	5
691	R:R:I364	R:R:V360	1.54	No	No	0	6	6
692	S:S:I367	S:S:V77	1.54	No	No	0	7	5
693	S:S:I315	S:S:V319	1.54	No	No	0	5	5
694	S:S:I364	S:S:V360	1.54	No	No	0	6	6
695	R:R:H173	R:R:P174	1.53	Yes	No	0	6	9
696	S:S:H173	S:S:P174	1.53	Yes	No	0	6	9
697	R:R:F137	R:R:G141	1.51	Yes	No	0	7	4
698	S:S:F137	S:S:G141	1.51	Yes	No	0	7	4
699	R:R:K178	R:R:T179	1.5	No	No	0	4	4
700	R:R:L167	R:R:V102	1.49	No	No	0	9	8
701	R:R:L167	R:R:V307	1.49	No	Yes	0	9	7
702	R:R:L195	S:S:V236	1.49	No	No	0	3	4
703	R:R:V236	S:S:L195	1.49	No	No	0	4	3
704	S:S:L167	S:S:V102	1.49	No	No	0	9	8
705	S:S:L167	S:S:V307	1.49	No	Yes	0	9	7
706	R:R:L343	R:R:T340	1.47	No	No	0	2	7
707	S:S:L343	S:S:T340	1.47	No	No	0	2	7
708	R:R:I367	R:R:L371	1.43	No	No	0	7	5
709	S:S:I367	S:S:L371	1.43	No	No	0	7	5
710	R:R:A198	R:R:F147	1.39	No	No	0	2	5
711	S:S:A198	S:S:F147	1.39	No	No	0	2	5
712	R:R:A302	R:R:R305	1.38	No	No	0	6	8
713	S:S:A302	S:S:R305	1.38	No	No	0	6	8
714	R:R:D56	R:R:N58	1.35	No	No	0	2	3
715	R:R:D345	R:R:N58	1.35	No	No	0	3	3
716	S:S:D56	S:S:N58	1.35	No	No	0	2	3
717	S:S:D345	S:S:N58	1.35	No	No	0	3	3
718	R:R:L95	R:R:Q96	1.33	No	No	0	5	4
719	R:R:F75	R:R:V76	1.31	No	No	0	6	5
720	R:R:R262	R:R:T258	1.29	No	No	0	5	1
721	R:R:Q96	R:R:Q99	1.28	No	Yes	0	4	7
722	S:S:Q96	S:S:Q99	1.28	No	Yes	0	4	7
723	R:R:K93	R:R:R91	1.24	No	No	0	7	6
724	R:R:M267	R:R:R263	1.24	No	No	0	6	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N52	6.16167	6	1	3
2	R:R:T59	6.985	4	0	2
3	R:R:Y71	6.90714	7	1	7
4	R:R:N82	7.62	4	0	9
5	R:R:Q99	5.0675	4	6	7
6	R:R:R101	10.138	5	4	6
7	R:R:Y105	7.378	5	4	8
8	R:R:A110	2.8975	4	0	9
9	R:R:L121	8.0075	4	1	7
10	R:R:D124	7.49167	6	1	7
11	R:R:L125	5.1575	4	1	6
12	R:R:F128	7.99333	6	1	6
13	R:R:I129	4.9075	4	1	5
14	R:R:W130	5.658	5	1	7
15	R:R:H133	5.6025	4	1	5
16	R:R:W135	7.91125	8	1	9
17	R:R:F137	7.838	5	1	7
18	R:R:Y145	9.966	5	1	6
19	R:R:Y146	9.806	5	1	5
20	R:R:R149	7.346	5	0	7
21	R:R:E150	11.3675	4	1	6
22	R:R:S162	6.055	4	4	7
23	R:R:E166	10.475	4	4	9
24	R:R:Y168	9.456	5	3	8
25	R:R:C172	8.74	4	3	7
26	R:R:H173	3.574	5	3	6
27	R:R:F189	10.4575	4	4	5
28	R:R:I193	4.8625	4	4	8
29	R:R:A196	1.5875	4	0	5
30	R:R:T207	4.6775	4	0	4
31	R:R:M208	8.1	4	1	5
32	R:R:L210	5.015	4	1	5
33	R:R:H219	8.1175	4	1	3
34	R:R:P227	6.202	5	1	5
35	R:R:N241	8.71667	6	1	5
36	R:R:F248	5.47	6	5	5
37	R:R:M250	4.7675	4	0	7
38	R:R:V259	4.0775	4	3	5
39	R:R:L264	6.1925	4	3	8
40	R:R:V307	2.7	4	0	7
41	R:R:W321	8.89667	6	1	8
42	R:R:Y324	8.738	5	1	5
43	R:R:H325	8.514	5	1	7
44	R:R:R327	7.64167	6	1	5
45	R:R:V332	4.1975	4	1	4
46	R:R:Y333	7.6325	4	1	5
47	R:R:W339	11.854	5	1	7
48	R:R:Y347	9.062	5	1	4
49	R:R:H348	10.805	4	1	4
50	R:R:F350	5.4375	4	0	5
51	R:R:Y351	10.8	5	1	4
52	R:R:N355	7.702	5	1	6
53	R:R:Y359	12.0125	4	1	7
54	S:S:N52	6.16167	6	2	3
55	S:S:T59	7.6725	4	0	2
56	S:S:Y71	6.90714	7	2	7
57	S:S:N82	7.62	4	0	9
58	S:S:Q99	5.0675	4	7	7
59	S:S:R101	10.386	5	5	6
60	S:S:Y105	6.73	6	5	8
61	S:S:A110	2.8975	4	0	9
62	S:S:L121	8.0075	4	2	7
63	S:S:D124	7.49167	6	2	7
64	S:S:L125	5.1575	4	2	6
65	S:S:F128	8.20167	6	2	6
66	S:S:I129	4.9075	4	2	5
67	S:S:W130	5.638	5	2	7
68	S:S:H133	5.6025	4	2	5
69	S:S:W135	7.76875	8	2	9
70	S:S:F137	7.02	5	2	7
71	S:S:Y145	9.57	5	2	6
72	S:S:Y146	9.176	5	2	5
73	S:S:R149	7.346	5	0	7
74	S:S:E150	11.3675	4	2	6
75	S:S:S162	5.7225	4	5	7
76	S:S:E166	10.475	4	5	9
77	S:S:Y168	9.456	5	3	8
78	S:S:C172	8.74	4	3	7
79	S:S:H173	3.574	5	3	6
80	S:S:F189	8.648	5	5	5
81	S:S:I193	4.8625	4	5	8
82	S:S:T207	4.2825	4	0	4
83	S:S:M208	8.1	4	2	5
84	S:S:L210	4.73	4	2	5
85	S:S:H219	7.3525	4	2	3
86	S:S:P227	6.202	5	2	5
87	S:S:N241	8.71667	6	2	5
88	S:S:F248	6.306	5	4	5
89	S:S:V259	4.0775	4	3	5
90	S:S:L264	6.1925	4	3	8
91	S:S:V307	2.7	4	0	7
92	S:S:W321	8.89667	6	2	8
93	S:S:Y324	8.738	5	2	5
94	S:S:H325	8.56	5	2	7
95	S:S:R327	7.82	6	2	5
96	S:S:V332	4.1975	4	2	4
97	S:S:Y333	7.375	4	2	5
98	S:S:W339	11.312	5	2	7
99	S:S:Y347	9.062	5	2	4
100	S:S:H348	10.805	4	2	4
101	S:S:F350	5.4375	4	0	5
102	S:S:Y351	10.8	5	2	4
103	S:S:N355	7.702	5	2	6
104	S:S:Y359	12.0125	4	2	7
105	L:L:Y11	5.9775	4	1	0
106	L:L:L13	6.3575	4	1	0
107	M:M:Y11	5.938	5	2	0
108	M:M:L13	6.6725	4	2	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:H133	R:R:N52	10.2323	5.1	Yes	Yes	1	5	3
2	L:L:Y11	R:R:H133	12.9458	3.27	Yes	Yes	1	0	5
3	L:L:I12	L:L:Y11	10.5867	6.04	No	Yes	1	0	0
4	R:R:D124	R:R:F128	17.6347	7.17	Yes	Yes	1	7	6
5	R:R:D124	R:R:Y71	22.7968	6.9	Yes	Yes	1	7	7
6	R:R:L121	R:R:Y71	13.6092	3.52	Yes	Yes	1	7	7
7	R:R:D124	R:R:Y359	11.1318	8.05	Yes	Yes	1	7	7
8	R:R:L121	R:R:Y359	17.7637	19.93	Yes	Yes	1	7	7
9	R:R:F75	R:R:L121	28.1767	3.65	No	Yes	0	6	7
10	R:R:F75	R:R:T79	22.357	7.78	No	No	0	6	6
11	R:R:L117	R:R:T79	19.2397	2.95	No	No	0	6	6
12	R:R:A362	R:R:L117	16.3145	4.73	No	No	0	9	6
13	R:R:A362	R:R:D113	15.3987	4.63	No	No	0	9	9
14	R:R:D113	R:R:N82	14.7882	13.46	No	Yes	0	9	9
15	R:R:D103	R:R:L89	17.8373	5.43	No	No	0	8	7
16	R:R:L89	R:R:T85	17.5204	2.95	No	No	0	7	9
17	R:R:S100	R:R:S94	18.3111	3.26	No	No	6	7	4
18	R:R:M208	R:R:P227	14.705	8.39	Yes	Yes	1	5	5
19	R:R:M208	R:R:T207	50.1288	3.01	Yes	Yes	0	5	4
20	R:R:T207	R:R:V237	99.1738	7.93	Yes	No	0	4	7
21	R:R:P203	R:R:V237	99.2426	3.53	No	No	0	8	7
22	R:R:I202	R:R:P203	99.6549	3.39	No	No	0	4	8
23	R:R:I202	S:S:I202	99.8214	4.42	No	No	0	4	4
24	S:S:I202	S:S:P203	100	3.39	No	No	0	4	8
25	R:R:L199	S:S:P203	27.1482	9.85	No	No	0	4	8
26	R:R:L195	R:R:L199	27.0309	5.54	No	No	0	3	4
27	R:R:L195	S:S:L240	26.8671	9.69	No	No	0	3	4
28	R:R:A196	S:S:L240	26.9339	1.58	Yes	No	0	5	4
29	R:R:A196	R:R:L158	49.4471	1.58	Yes	No	0	5	7
30	R:R:I193	R:R:L158	49.3603	4.28	Yes	No	0	8	7
31	R:R:I193	R:R:S162	38.9705	4.64	Yes	Yes	4	8	7
32	R:R:S162	R:R:Y105	36.8558	6.36	Yes	Yes	4	7	8
33	R:R:E166	R:R:Y105	17.2376	11.22	Yes	Yes	4	9	8
34	R:R:E166	R:R:R101	16.924	12.79	Yes	Yes	4	9	6
35	R:R:F128	R:R:Y146	34.5172	6.19	Yes	Yes	1	6	5
36	R:R:M208	R:R:Y146	30.3897	16.76	Yes	Yes	1	5	5
37	R:R:M204	R:R:Y146	30.0659	4.79	No	Yes	0	6	5
38	R:R:M204	R:R:T207	48.8048	3.01	No	Yes	0	6	4
39	R:R:T186	R:R:Y105	17.0585	4.99	No	Yes	4	7	8
40	R:R:R101	R:R:T186	16.9242	11.64	Yes	No	4	6	7
41	R:R:R183	R:R:S100	17.4759	13.18	No	No	6	4	7
42	R:R:R183	R:R:S97	18.1056	9.22	No	No	0	4	5
43	R:R:L98	R:R:R101	26.6461	8.5	No	Yes	0	8	6
44	R:R:L98	R:R:R299	25.8765	3.64	No	No	0	8	5
45	R:R:E150	R:R:M204	19.5579	14.89	Yes	No	0	6	6
46	R:R:E150	R:R:N241	11.8588	17.09	Yes	Yes	1	6	5
47	R:R:F248	S:S:V161	21.5788	3.93	Yes	No	0	5	7
48	S:S:V161	S:S:V252	21.8119	3.21	No	No	0	7	5
49	S:S:F248	S:S:V252	22.1203	3.93	Yes	No	0	5	5
50	R:R:S162	S:S:F248	14.6297	6.61	Yes	Yes	4	7	5
51	R:R:L256	R:R:V252	14.4572	2.98	No	No	0	7	5
52	R:R:F248	R:R:V252	14.865	3.93	Yes	No	0	5	5
53	R:R:C172	R:R:I171	20.8027	3.27	Yes	No	3	7	8
54	R:R:I171	R:R:L303	20.7692	7.14	No	No	3	8	8
55	R:R:L303	R:R:R299	23.3814	3.64	No	No	0	8	5
56	R:R:C172	R:R:Y168	17.0476	16.13	Yes	Yes	3	7	8
57	R:R:L256	R:R:V165	13.2803	2.98	No	No	0	7	6
58	R:R:L169	R:R:V165	12.5736	2.98	No	No	0	4	6
59	R:R:H173	R:R:L169	11.9673	3.86	Yes	No	0	6	4
60	R:R:V259	R:R:Y168	12.7953	3.79	Yes	Yes	3	5	8
61	R:R:Y168	S:S:V259	12.1165	3.79	Yes	Yes	3	8	5
62	S:S:P203	S:S:V237	75.8894	3.53	No	No	0	8	7
63	S:S:T207	S:S:V237	75.8753	6.35	Yes	No	0	4	7
64	S:S:M208	S:S:T207	40.6582	3.01	Yes	Yes	0	5	4
65	S:S:M208	S:S:P227	10.4639	8.39	Yes	Yes	2	5	5
66	R:R:F248	S:S:S162	24.7612	5.28	Yes	Yes	5	5	7
67	R:R:V259	S:S:Y168	11.5678	3.79	Yes	Yes	3	5	8
68	S:S:V259	S:S:Y168	11.5847	3.79	Yes	Yes	3	5	8
69	S:S:M204	S:S:T207	37.2052	3.01	No	Yes	0	6	4
70	S:S:M204	S:S:Y146	32.8366	4.79	No	Yes	0	6	5
71	S:S:F128	S:S:Y146	29.9354	6.19	Yes	Yes	2	6	5
72	M:M:I12	M:M:Y11	14.3429	8.46	No	Yes	2	0	0
73	M:M:Y11	S:S:H133	11.4686	3.27	Yes	Yes	2	0	5
74	S:S:M208	S:S:Y146	29.9999	16.76	Yes	Yes	2	5	5
75	S:S:D124	S:S:F128	19.234	7.17	Yes	Yes	2	7	6
76	S:S:D124	S:S:Y71	21.7741	6.9	Yes	Yes	2	7	7
77	S:S:Y145	S:S:Y146	31.08	9.93	Yes	Yes	2	6	5
78	S:S:D124	S:S:Y145	18.648	6.9	Yes	Yes	2	7	6
79	S:S:E150	S:S:M204	13.4269	14.89	Yes	No	0	6	6
80	S:S:E150	S:S:N241	10.337	17.09	Yes	Yes	2	6	5
81	S:S:H325	S:S:N241	10.5004	5.1	Yes	Yes	2	7	5
82	S:S:L121	S:S:Y71	17.215	3.52	Yes	Yes	2	7	7
83	S:S:D124	S:S:Y359	15.7655	8.05	Yes	Yes	2	7	7
84	S:S:L121	S:S:Y359	26.5636	19.93	Yes	Yes	2	7	7
85	S:S:R149	S:S:Y145	16.429	16.46	Yes	Yes	0	7	6
86	S:S:R149	S:S:Y359	13.4693	6.17	Yes	Yes	0	7	7
87	S:S:F75	S:S:L121	41.0998	3.65	No	Yes	0	6	7
88	S:S:F75	S:S:T79	39.761	7.78	No	No	0	6	6
89	S:S:L117	S:S:T79	35.7833	2.95	No	No	0	6	6
90	S:S:A362	S:S:L117	26.5063	4.73	No	No	0	9	6
91	S:S:A362	S:S:D113	25.4008	4.63	No	No	0	9	9
92	S:S:D113	S:S:N82	24.3401	13.46	No	Yes	0	9	9
93	S:S:N82	S:S:P366	11.9222	9.77	Yes	No	0	9	9
94	S:S:L89	S:S:T85	13.3494	2.95	No	No	0	7	9
95	S:S:D103	S:S:L89	11.5944	5.43	No	No	0	8	7
96	S:S:S162	S:S:Y105	21.533	6.36	Yes	Yes	5	7	8
97	S:S:A120	S:S:R149	17.352	4.15	No	Yes	0	6	7
98	S:S:A120	S:S:I116	17.0513	3.25	No	No	0	6	7
99	S:S:C152	S:S:I116	16.7737	6.55	No	No	0	7	7
100	S:S:C152	S:S:L115	16.6543	3.17	No	No	0	7	6
101	S:S:L111	S:S:L115	16.622	4.15	No	No	0	6	6
102	S:S:L111	S:S:W194	16.6012	4.56	No	No	0	6	9
103	S:S:S108	S:S:W194	16.6727	4.94	No	No	0	9	9
104	S:S:N159	S:S:S108	11.327	8.94	No	No	0	8	9
105	R:R:A196	S:S:L200	23.3326	1.58	Yes	No	0	5	5
106	S:S:L200	S:S:Y154	23.2588	11.72	No	No	0	5	6
107	S:S:N241	S:S:Y154	21.2718	10.47	Yes	No	2	5	6
108	S:S:C172	S:S:Y168	11.605	16.13	Yes	Yes	3	7	8
109	S:S:R327	S:S:Y324	10.9515	4.12	Yes	Yes	2	5	5
110	R:R:R101	R:R:S97	18.2051	6.59	Yes	No	0	6	5
111	R:R:F331	R:R:Y347	12.6023	7.22	No	Yes	1	3	4
112	R:R:D124	R:R:Y145	16.6626	6.9	Yes	Yes	1	7	6
113	R:R:Y145	R:R:Y146	26.3194	11.91	Yes	Yes	1	6	5

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
S:S:H133	S:S:N52	5.1	2	Yes	Yes	5	3	1	2
S:S:H133	S:S:L55	9	2	Yes	No	5	2	1	1
S:S:L213	S:S:L55	4.15	0	No	No	2	2	2	1
M:M:Y11	S:S:L55	5.86	2	Yes	No	0	2	0	1
S:S:D56	S:S:H133	5.04	0	No	Yes	2	5	2	1
S:S:H132	S:S:V57	23.52	0	No	No	5	2	1	2
S:S:H348	S:S:V57	15.22	2	Yes	No	4	2	1	2
S:S:H132	S:S:K64	3.93	0	No	No	5	5	1	2
S:S:D124	S:S:F128	7.17	2	Yes	Yes	7	6	2	1
S:S:D124	S:S:Y145	6.9	2	Yes	Yes	7	6	2	2
S:S:D124	S:S:Y351	9.2	2	Yes	Yes	7	4	2	1
S:S:D124	S:S:N355	6.73	2	Yes	Yes	7	6	2	2
S:S:F128	S:S:W135	7.02	2	Yes	Yes	6	9	1	2
S:S:F128	S:S:Y145	8.25	2	Yes	Yes	6	6	1	2
S:S:F128	S:S:Y146	6.19	2	Yes	Yes	6	5	1	1
S:S:F128	S:S:Y351	9.28	2	Yes	Yes	6	4	1	1
M:M:I12	S:S:F128	11.3	2	No	Yes	0	6	0	1
M:M:Y11	S:S:H132	3.27	2	Yes	No	0	5	0	1
M:M:Y11	S:S:H133	3.27	2	Yes	Yes	0	5	0	1
S:S:Y145	S:S:Y146	9.93	2	Yes	Yes	6	5	2	1
S:S:M204	S:S:Y146	4.79	0	No	Yes	6	5	2	1
S:S:M208	S:S:Y146	16.76	2	Yes	Yes	5	5	1	1
M:M:L13	S:S:Y146	8.21	2	Yes	Yes	0	5	0	1
S:S:M204	S:S:T207	3.01	0	No	Yes	6	4	2	2
S:S:M208	S:S:T207	3.01	2	Yes	Yes	5	4	1	2
S:S:M208	S:S:P227	8.39	2	Yes	Yes	5	5	1	1
M:M:L13	S:S:M208	4.24	2	Yes	Yes	0	5	0	1
S:S:L213	S:S:V224	4.47	0	No	No	2	5	2	1
S:S:T226	S:S:V224	3.17	0	No	No	3	5	2	1
M:M:Y11	S:S:V224	8.83	2	Yes	No	0	5	0	1
S:S:P227	S:S:T226	6.99	2	Yes	No	5	3	1	2
S:S:L234	S:S:P227	6.57	2	No	Yes	5	5	2	1
S:S:F331	S:S:P227	5.78	2	No	Yes	3	5	1	1
M:M:L13	S:S:P227	3.28	2	Yes	Yes	0	5	0	1
S:S:R327	S:S:Y347	9.26	2	Yes	Yes	5	4	2	1
S:S:R327	S:S:Y351	14.4	2	Yes	Yes	5	4	2	1
S:S:N355	S:S:R327	4.82	2	Yes	Yes	6	5	2	2
S:S:F331	S:S:Y347	7.22	2	No	Yes	3	4	1	1
M:M:L13	S:S:F331	10.96	2	Yes	No	0	3	0	1
S:S:I334	S:S:W339	12.92	0	No	Yes	3	7	2	1
M:M:R9	S:S:D336	9.53	0	No	No	0	2	0	1
S:S:L343	S:S:W339	7.97	0	No	Yes	2	7	2	1
S:S:W339	S:S:Y347	4.82	2	Yes	Yes	7	4	1	1
M:M:R9	S:S:W339	15.99	0	No	Yes	0	7	0	1
M:M:P10	S:S:W339	14.86	2	No	Yes	0	7	0	1
M:M:R8	S:S:T341	3.88	0	No	No	0	4	0	1
S:S:F344	S:S:H348	14.71	0	No	Yes	3	4	1	1
M:M:R8	S:S:F344	21.38	0	No	No	0	3	0	1
S:S:H348	S:S:Y347	8.71	2	Yes	Yes	4	4	1	1
M:M:P10	S:S:Y347	15.3	2	No	Yes	0	4	0	1
M:M:P10	S:S:H348	4.58	2	No	Yes	0	4	0	1
S:S:N355	S:S:Y351	16.28	2	Yes	Yes	6	4	2	1
M:M:I12	S:S:Y351	4.84	2	No	Yes	0	4	0	1
S:S:D345	S:S:F344	2.39	0	No	No	3	3	2	1
M:M:G7	S:S:D336	1.68	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:H133	R:R:N52	5.1	1	Yes	Yes	5	3	1	2
R:R:H133	R:R:L55	9	1	Yes	No	5	2	1	1
L:L:Y11	R:R:L55	7.03	1	Yes	No	0	2	0	1
R:R:D56	R:R:H133	5.04	0	No	Yes	2	5	2	1
R:R:H348	R:R:V57	15.22	1	Yes	No	4	2	1	2
R:R:D124	R:R:F128	7.17	1	Yes	Yes	7	6	2	1
R:R:D124	R:R:Y145	6.9	1	Yes	Yes	7	6	2	2
R:R:D124	R:R:Y351	9.2	1	Yes	Yes	7	4	2	1
R:R:D124	R:R:N355	6.73	1	Yes	Yes	7	6	2	2
R:R:F128	R:R:W135	7.02	1	Yes	Yes	6	9	1	2
R:R:F128	R:R:Y145	8.25	1	Yes	Yes	6	6	1	2
R:R:F128	R:R:Y146	6.19	1	Yes	Yes	6	5	1	1
R:R:F128	R:R:Y351	9.28	1	Yes	Yes	6	4	1	1
L:L:I12	R:R:F128	10.05	1	No	Yes	0	6	0	1
L:L:Y11	R:R:H133	3.27	1	Yes	Yes	0	5	0	1
R:R:Y145	R:R:Y146	11.91	1	Yes	Yes	6	5	2	1
R:R:M204	R:R:Y146	4.79	0	No	Yes	6	5	2	1
R:R:M208	R:R:Y146	16.76	1	Yes	Yes	5	5	1	1
L:L:L13	R:R:Y146	9.38	1	Yes	Yes	0	5	0	1
R:R:M204	R:R:T207	3.01	0	No	Yes	6	4	2	2
R:R:M208	R:R:T207	3.01	1	Yes	Yes	5	4	1	2
R:R:M208	R:R:P227	8.39	1	Yes	Yes	5	5	1	1
L:L:L13	R:R:M208	4.24	1	Yes	Yes	0	5	0	1
R:R:L213	R:R:V224	4.47	0	No	No	2	5	2	1
R:R:T226	R:R:V224	3.17	0	No	No	3	5	2	1
L:L:Y11	R:R:V224	7.57	1	Yes	No	0	5	0	1
R:R:P227	R:R:T226	6.99	1	Yes	No	5	3	1	2
R:R:L234	R:R:P227	6.57	1	No	Yes	5	5	2	1
R:R:F331	R:R:P227	5.78	1	No	Yes	3	5	1	1
L:L:L13	R:R:P227	3.28	1	Yes	Yes	0	5	0	1
R:R:R327	R:R:Y347	9.26	1	Yes	Yes	5	4	2	1
R:R:R327	R:R:Y351	14.4	1	Yes	Yes	5	4	2	1
R:R:N355	R:R:R327	4.82	1	Yes	Yes	6	5	2	2
R:R:F331	R:R:Y347	7.22	1	No	Yes	3	4	1	1
L:L:L13	R:R:F331	8.53	1	Yes	No	0	3	0	1
R:R:I334	R:R:W339	12.92	0	No	Yes	3	7	2	1
L:L:R9	R:R:D336	5.96	0	No	No	0	2	0	1
R:R:L343	R:R:W339	7.97	0	No	Yes	2	7	2	1
R:R:W339	R:R:Y347	4.82	1	Yes	Yes	7	4	1	1
L:L:R9	R:R:W339	15.99	0	No	Yes	0	7	0	1
L:L:P10	R:R:W339	17.57	1	No	Yes	0	7	0	1
R:R:F344	R:R:H348	14.71	0	No	Yes	3	4	1	1
L:L:R8	R:R:F344	26.72	0	No	No	0	3	0	1
R:R:H348	R:R:Y347	8.71	1	Yes	Yes	4	4	1	1
L:L:P10	R:R:Y347	15.3	1	No	Yes	0	4	0	1
L:L:P10	R:R:H348	4.58	1	No	Yes	0	4	0	1
R:R:N355	R:R:Y351	16.28	1	Yes	Yes	6	4	2	1
L:L:I12	R:R:Y351	4.84	1	No	Yes	0	4	0	1
L:L:R8	R:R:T341	2.59	0	No	No	0	4	0	1
L:L:G7	R:R:D336	1.68	0	No	No	0	2	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	6YVR_poly
Class	A
SubFamily	Peptide
Type	Neurotensin
SubType	NTS1
Species	Rattus norvegicus
Ligand	NTS8-13
Other Ligand(s)	-
Protein Partners	-
PDB Resolution	2.46
Date	2021-02-10
D.O.I.	10.1126/sciadv.abe5504

Net Summary
I_min	3.01
Number of Linked Nodes	593
Number of Links	724
Number of Hubs	108
Number of Links mediated by Hubs	383
Number of Communities	9
Number of Nodes involved in Communities	158
Number of Links involved in Communities	245

Path Summary
Number Of Nodes in MetaPath	114
Number Of Links MetaPath	113
Number of Shortest Paths	1121690
Length Of Smallest Path	3
Average Path Length	23.6774
Length of Longest Path	42
Minimum Path Strength	1.305
Average Path Strength	6.29787
Maximum Path Strength	20.715
Minimum Path Correlation	0.7
Average Path Correlation	0.966953
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	2.94118
Average % Of Corr. Nodes	40.6726
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.1342
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function
Gene Ontology	Biological Process
Gene Ontology	Cellular Component
SCOP2	Domain Identifier
SCOP2	Family Identifier
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P20789
Sequence	>6YVR_poly_Chain_R G P N S D L D V N T D I Y S K V L V T A I Y L A L F V V G T V G N G V T L F T L A R K K S L Q S L Q S R V D Y Y L G S L A L S D L L I L L F A L P V D L Y N F I W V H H P W A F G D A G C K G Y Y F L R E A C T Y A T A L N V V S L S V E L Y L A I C H P F K A K T L M S R S R T K K F I S A I W L A S A L L A I P M L F T M G L Q N L S G D G T H P G G L V C T P I V D T A T L R V V I Q L N T F M S F L F P M L V A S I L N T V A A R R L T V M V H Q I E P G R V Q A L R R G V L V L R A V V I A F V V C W L P Y H V R R L M F V Y I S D E Q W T T A L F D F Y H Y F Y M L S N A L V Y V S A A I N P I L Y N L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	3ZEV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3	2014-01-29	10.1073/pnas.1317903111
	4BUO	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.75	2014-01-29	10.1073/pnas.1317903111
	4BV0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.1	2014-01-29	10.1073/pnas.1317903111
	4BWB	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.57	2014-01-29	10.1073/pnas.1317903111
	4GRV	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin 8-13	-	-	2.8	2012-10-17	10.1038/nature11558
	4XEE	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.9	2015-07-29	10.1038/ncomms8895
	4XES	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	2.6	2015-07-29	10.1038/ncomms8895
	5T04	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	-	3.3	2016-12-21	10.1038/srep38564
	6OS9	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/&β;1/&γ;2	3	2019-07-10	10.1038/s41586-019-1337-6
	6OSA	A	Peptide	Neurotensin	NTS₁	Homo sapiens	JMV449	-	Gi1/&β;1/&γ;2	3	2019-07-10	10.1038/s41586-019-1337-6
	6PWC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.9	2019-12-04	10.1038/s41422-019-0256-2
	6UP7	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	-	Arrestin2	4.2	2020-02-26	10.1038/s41586-020-1953-1
	6YVR	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504
	6Z4Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR142948A	-	-	2.92	2021-02-10	10.1126/sciadv.abe5504
	6Z4S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.71	2021-02-10	10.1126/sciadv.abe5504
	6Z4V	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.6	2021-02-10	10.1126/sciadv.abe5504
	6Z66	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	-	-	-	3.19	2021-02-10	10.1126/sciadv.abe5504
	6Z8N	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SRI-9829	-	-	2.8	2021-02-10	10.1126/sciadv.abe5504
	6ZA8	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	RTI-3a	-	-	2.72	2021-02-10	10.1126/sciadv.abe5504
	6ZIN	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	SR48692	-	-	2.64	2021-02-10	10.1126/sciadv.abe5504
	7L0P	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/&γ;1	4.1	2021-01-06	10.1038/s41594-020-00554-6
	7L0Q	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/&γ;1	4.3	2021-01-06	10.1038/s41594-020-00554-6
	7L0R	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/&γ;1	4.2	2021-01-06	10.1038/s41594-020-00554-6
	7L0S	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin	-	Gi1/&β;1/γ1	4.5	2021-01-06	10.1038/s41594-020-00554-6
	7UL2	A	Peptide	Neurotensin	NTS₁	Homo sapiens	SR48692	Na	-	2.4	2022-06-29	10.1038/s41594-022-00859-8
	8FMZ	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/neuromedin N	-	chim(NtGi2L-Gs-CtGq)/&β;1/&γ;2	2.59	2023-03-29	10.1021/acs.biochem.3c00029
	8FN0	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/neuromedin N	PubChem 118610427	chim(NtGi1-Go)/&β;1/&γ;2	2.89	2023-03-29	10.1021/acs.biochem.3c00029
	8FN1	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	Neurotensin/neuromedin N	-	chim(NtGi1-Go)/&β;1/&γ;2	2.88	2023-03-29	10.1021/acs.biochem.3c00029
	8JPB	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin 8-13	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPC	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin 8-13	PubChem 118610427; GDP; Mg	Gq; GRK2	3.07	2023-08-09	10.1038/s41586-023-06395-9
	8JPF	A	Peptide	Neurotensin	NTS₁	Homo sapiens	Neurotensin	PubChem 118610427	-	3.02	2023-08-09	10.1038/s41586-023-06395-9
	6YVR (Dimer)	A	Peptide	Neurotensin	NTS₁	Rattus norvegicus	NTS8-13	-	-	2.46	2021-02-10	10.1126/sciadv.abe5504

You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 6YVR_poly.zip

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