Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:R42 5.6575419
2A:A:L46 2.735418
3A:A:F219 4.8575408
4A:A:Q227 5.356519
5A:A:K233 4.19333619
6A:A:W234 3.85429719
7A:A:F238 6.5419
8A:A:I244 2.205418
9A:A:I245 2.795407
10A:A:Y253 8.354538
11A:A:N254 11.515439
12A:A:F273 6.195499
13A:A:W277 7.07696
14A:A:W281 7.5225405
15A:A:F290 3.3575409
16A:A:K293 6.9054159
17A:A:S306 6.6175437
18A:A:I308 4.7325437
19A:A:F312 5.02738
20A:A:F315 9.57406
21A:A:Y318 5.58536
22A:A:E327 4.8975404
23A:A:F340 7.74143737
24A:A:F345 7.015408
25A:A:S349 3.1975497
26A:A:Y360 8.5478
27A:A:H362 6.87479
28A:A:R373 4.6275405
29A:A:D378 6.8725477
30A:A:R385 7.054505
31B:B:L14 3.02508
32B:B:R22 8.0754106
33B:B:R48 9.815427
34B:B:H54 7.80167649
35B:B:W63 5.198527
36B:B:R68 7.4554195
37B:B:V71 2.1875408
38B:B:D76 4.43649
39B:B:K78 5.4825448
40B:B:I80 8448
41B:B:W82 7.2925849
42B:B:W99 5.24167619
43B:B:M101 5.245409
44B:B:Y105 2.57406
45B:B:N110 8.19254124
46B:B:C114 3.82408
47B:B:G115 2.3275409
48B:B:L117 3.732519
49B:B:C121 2.8475418
50B:B:Y124 5.402506
51B:B:V133 3.8985204
52B:B:L139 7.5275419
53B:B:H142 5.34714719
54B:B:Y145 3.6718
55B:B:L146 3.7175417
56B:B:C148 2.8885116
57B:B:F151 7.6154219
58B:B:T159 3.172519
59B:B:S160 3.5365116
60B:B:G162 2.7525419
61B:B:D163 5.674519
62B:B:W169 8.52667618
63B:B:F180 3.58833687
64B:B:H183 7.21409
65B:B:D186 3.748519
66B:B:F199 7.6175489
67B:B:C204 5.135417
68B:B:W211 7.028588
69B:B:H225 10.876519
70B:B:D228 4.77519
71B:B:F234 3.32405
72B:B:F235 6.23429716
73B:B:N237 10.72415
74B:B:N239 6.21412
75B:B:F241 4.598516
76B:B:T243 5.405418
77B:B:G244 2.76415
78B:B:S245 6.255419
79B:B:D247 6.416519
80B:B:T249 7.5125416
81B:B:C250 3.0075418
82B:B:R251 12.068518
83B:B:F253 4.438516
84B:B:D254 3.82519
85B:B:R256 8.022519
86B:B:Y264 9.475405
87B:B:I269 5.6825404
88B:B:C271 4.79415
89B:B:I273 5.4475416
90B:B:T274 2.695458
91B:B:S275 3.16408
92B:B:V276 2.5925416
93B:B:F278 4.295617
94B:B:S281 2.695409
95B:B:R283 4.8525469
96B:B:A287 2.3375416
97B:B:Y289 6.586517
98B:B:N295 5.24516
99B:B:W297 8.4475418
100B:B:D298 3.8225469
101B:B:L300 4.17333666
102B:B:K301 3.9575465
103B:B:H311 8.06559
104B:B:R314 9.835408
105B:B:V315 3.0975457
106B:B:L318 3.705406
107B:B:T321 5.545427
108B:B:T329 4.4125458
109B:B:W332 8.4045189
110B:B:D333 6.715459
111B:B:K337 6.298556
112B:B:W339 7.946559
113B:B:N340 7.18529
114G:G:Q18 8.83409
115G:G:R27 5.48754108
116G:G:V30 3.4575408
117G:G:M38 1.85404
118G:G:H44 10.945406
119G:G:D48 5.05833609
120G:G:L51 3.48406
121G:G:V54 3.585426
122G:G:N59 5.3075429
123G:G:P60 6.8375429
124G:G:F61 4.87857728
125R:R:I28 2.30754238
126R:R:N32 5.2825409
127R:R:G61 1.875409
128R:R:G65 2.2054239
129R:R:L68 4.61406
130R:R:C85 4.2154149
131R:R:Y89 2.2275405
132R:R:S95 2.82754255
133R:R:N102 5.14254138
134R:R:H107 5.4525409
135R:R:E109 4.6775409
136R:R:Q119 3.72254285
137R:R:P135 3.025408
138R:R:P142 3.58754268
139R:R:F233 4.8925409
140R:R:W237 6.936508
141R:R:Y240 7.6885277
142R:R:P255 2.9404
143R:R:P277 2.62409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:H54 B:B:S74 10.182712.55YesNo499
2A:A:I245 A:A:V247 78.28561.54YesNo077
3A:A:S51 A:A:V247 78.46011.62NoNo097
4A:A:A249 A:A:S51 78.63423.42NoNo089
5A:A:A249 A:A:K293 78.7563.21NoYes1589
6A:A:K293 A:A:S251 79.3287.65YesNo099
7A:A:L296 A:A:S251 79.50079.01NoNo069
8A:A:K300 A:A:L296 79.6738.46NoNo096
9A:A:K300 A:A:Y253 79.58027.17NoYes398
10A:A:L266 A:A:Y253 90.29652.34NoYes088
11A:A:L266 A:A:V248 97.16031.49NoNo087
12A:A:A269 A:A:V248 97.29851.7NoNo097
13A:A:A269 A:A:F246 98.79912.77NoNo099
14A:A:F246 A:A:L46 99.20213.65NoYes098
15A:A:L44 A:A:L46 99.25254.15NoYes198
16A:A:F238 A:A:L44 1008.53YesNo199
17A:A:F238 B:B:W99 23.072911.02YesYes199
18B:B:Q75 B:B:W99 14.62272.19NoYes099
19B:B:A56 B:B:Q75 10.3763.03NoNo079
20A:A:F290 A:A:H362 37.82294.53YesYes099
21A:A:F290 A:A:I245 72.31362.51YesYes097
22A:A:F238 A:A:W234 38.76334.01YesYes199
23B:B:M101 B:B:Y145 23.11534.79YesYes098
24B:B:L117 B:B:Y145 39.54332.34YesYes198
25A:A:K233 B:B:Y145 50.52142.39YesYes198
26A:A:K233 B:B:D228 52.37545.53YesYes199
27A:A:I308 A:A:Y253 16.47318.46YesYes378
28A:A:F345 A:A:L266 10.76392.44YesNo088
29A:A:F290 A:A:I288 34.12493.77YesNo099
30A:A:D378 A:A:I288 33.7982.8YesNo079
31A:A:D378 A:A:H362 33.862915.13YesYes779
32A:A:F340 A:A:I308 14.54872.51YesYes377
33A:A:D378 A:A:D381 67.34442.66YesNo778
34A:A:D381 A:A:Q384 66.43842.61NoNo786
35A:A:Q384 R:R:V114 66.29172.87NoNo068
36R:R:L115 R:R:V114 60.02312.98NoNo068
37R:R:L115 R:R:Y111 58.672211.72NoNo069
38R:R:V188 R:R:Y111 56.41482.52NoNo099
39A:A:L393 R:R:V188 53.24181.49NoNo089
40A:A:L393 R:R:R110 52.78743.64NoNo089
41A:A:Y391 R:R:R110 15.15527.2NoNo049
42A:A:Y391 R:R:E109 14.20995.61NoYes049
43B:B:G116 B:B:M101 24.74331.75NoYes099
44B:B:G115 B:B:G116 24.55352.11YesNo099
45B:B:G115 B:B:T102 24.58241.82YesNo098
46B:B:C148 B:B:T102 24.59573.38YesNo068
47B:B:H183 B:B:V187 10.84474.15YesNo099
48B:B:C218 G:G:Q18 17.74629.16NoYes059
49G:G:E22 G:G:Q18 12.689315.29NoYes099
50G:G:E22 G:G:L19 11.00122.65NoNo099
51B:B:C148 B:B:S160 17.91941.72YesYes1166
52B:B:Q259 G:G:V30 10.53115.73NoYes068
53B:B:N239 B:B:R256 10.492910.85YesYes129
54B:B:L300 G:G:C41 13.40171.59YesNo067
55G:G:C41 G:G:M38 11.91381.62NoYes074
56B:B:L30 B:B:L300 14.90584.15NoYes656
57B:B:L30 B:B:M262 21.63894.24NoNo054
58B:B:H142 B:B:W169 13.48492.12YesYes198
59B:B:G162 B:B:Y145 14.33465.79YesYes198
60B:B:D163 B:B:G162 10.23531.68YesYes199
61B:B:F234 B:B:G238 15.16493.01YesNo057
62B:B:D228 B:B:S227 40.63552.94YesNo196
63B:B:D247 B:B:S227 41.507311.78YesNo196
64B:B:D247 B:B:H225 18.68195.04YesYes199
65B:B:H225 B:B:T243 17.15068.21YesYes198
66B:B:F241 B:B:T243 15.21222.59YesYes168
67B:B:F234 B:B:F241 15.94852.14YesYes056
68B:B:D247 B:B:S245 20.32774.42YesYes199
69B:B:D228 B:B:D246 14.575.32YesNo199
70B:B:G244 B:B:S245 20.59133.71YesYes159
71B:B:C271 B:B:D291 15.58099.34YesNo058
72B:B:M262 B:B:Y264 23.02417.18NoYes045
73B:B:W297 B:B:Y289 12.15646.75YesYes187
74B:B:W297 B:B:Y264 26.148522.19YesYes085
75R:R:H107 R:R:R110 37.31275.64YesNo099
76R:R:H107 R:R:L103 35.92076.43YesNo099
77R:R:L103 R:R:W237 35.4593.42NoYes098
78R:R:W237 R:R:Y240 10.03625.79YesYes087
79R:R:V276 R:R:W237 20.963211.03NoYes098
80R:R:P277 R:R:V276 19.70463.53YesNo099
81R:R:G61 R:R:P277 18.33612.03YesYes099
82R:R:G61 R:R:T64 13.07251.82YesNo098
83R:R:E109 R:R:F53 11.87337YesNo098
84R:R:F53 R:R:L105 11.412310.96NoNo086
85A:A:W234 B:B:Y145 38.47721.93YesYes198
86B:B:D246 B:B:G272 15.42315.03NoNo194
87B:B:A287 B:B:W297 11.41972.59YesYes168
88B:B:G238 B:B:N239 11.921.7NoYes172
89A:A:F238 B:B:L117 38.46142.44YesYes199
90B:B:C271 B:B:G272 13.95841.96YesNo154
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7BW0
Class A
SubFamily Steroid
Type Bile Acid
SubType GPBA
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.9
Date 2020-09-02
D.O.I. doi.org/10.1038/s41392-020-00262-z
Net Summary
Imin 1.64
Number of Linked Nodes 824
Number of Links 981
Number of Hubs 143
Number of Links mediated by Hubs 516
Number of Communities 28
Number of Nodes involved in Communities 204
Number of Links involved in Communities 282
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 1069045
Length Of Smallest Path 3
Average Path Length 30.3584
Length of Longest Path 62
Minimum Path Strength 1.085
Average Path Strength 4.89319
Maximum Path Strength 24.075
Minimum Path Correlation 0.7
Average Path Correlation 0.982047
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 48.2751
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 45.3023
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process• cellular response to nitrogen compound   • cellular response to stimulus   • response to dopamine   • regulation of cellular process   • response to stimulus   • signaling   • cellular response to dopamine   • response to monoamine   • cell communication   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • signal transduction   • regulation of biological process   • G protein-coupled dopamine receptor signaling pathway   • biological regulation   • response to oxygen-containing compound   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to oxygen-containing compound   • cellular response to chemical stimulus   • cellular response to monoamine stimulus   • response to chemical   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • cellular process   • G protein-coupled receptor signaling pathway   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • response to hormone   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cell periphery   • cellular anatomical structure   • plasma membrane   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • cytoskeletal protein binding   • spectrin binding   • protein-containing complex binding   • protein binding   • binding   • enzyme binding   • GTPase binding   • phosphoric ester hydrolase activity   • alkylglycerophosphoethanolamine phosphodiesterase activity   • hydrolase activity, acting on ester bonds   • phosphoric diester hydrolase activity   • hydrolase activity   • catalytic activity   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity, acting on acid anhydrides   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • positive regulation of cytosolic calcium ion concentration   • biological regulation   • regulation of biological quality   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • response to decreased oxygen levels   • cellular response to stimulus   • response to stimulus   • cellular response to oxygen levels   • cellular response to hypoxia   • cellular response to decreased oxygen levels   • cellular response to chemical stimulus   • cellular response to stress   • response to hypoxia   • response to stress   • response to chemical   • response to oxygen levels   • response to abiotic stimulus   • cellular process   • cell population proliferation   • regulation of biological process   • regulation of cellular process   • signaling   • phospholipase C-activating G protein-coupled receptor signaling pathway   • cell communication   • G protein-coupled receptor signaling pathway   • signal transduction   • muscle cell apoptotic process   • striated muscle cell apoptotic process   • apoptotic process   • cell death   • programmed cell death   • cardiac muscle cell apoptotic process   • photoreceptor inner segment   • somatodendritic compartment   • cell projection   • dendrite   • dendritic tree   • neuron projection   • plasma membrane bounded cell projection   • intracellular anatomical structure   • cytoplasm   • membrane-bounded organelle   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • photoreceptor outer segment   • photoreceptor cell cilium   • organelle   • ciliary membrane   • photoreceptor outer segment membrane   • bounding membrane of organelle   • plasma membrane region   • organelle membrane   • cell projection membrane   • synapse   • cell junction   • cell body   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • G-protein beta/gamma-subunit complex binding   • G protein activity   • molecular function regulator activity   • enzyme regulator activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • molecular function activator activity   • adenylate cyclase regulator activity   • adenylate cyclase activator activity   • cation binding   • metal ion binding   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • cellular homeostasis   • chemical homeostasis   • homeostatic process   • glucose homeostasis   • carbohydrate homeostasis   • intracellular chemical homeostasis   • intracellular glucose homeostasis   • neuromuscular process   • regulation of system process   • skeletal muscle contraction   • muscle contraction   • muscle system process   • regulation of muscle system process   • striated muscle contraction   • multicellular organismal movement   • musculoskeletal movement   • regulation of striated muscle contraction   • regulation of muscle contraction   • regulation of skeletal muscle contraction   • regulation of multicellular organismal process   • sensory perception of smell   • cellular response to nitrogen compound   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • response to hormone   • cellular response to hormone stimulus   • skeletal system development   • bone development   • response to pH   • cellular response to pH   • cellular response to acidic pH   • response to acidic pH   • cellular response to abiotic stimulus   • cellular response to environmental stimulus   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • coagulation   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • positive regulation of biological process   • adaptive thermogenesis   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • positive regulation of cell communication   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • positive regulation of establishment of protein localization   • localization   • establishment of localization in cell   • positive regulation of insulin secretion involved in cellular response to glucose stimulus   • positive regulation of insulin secretion   • intracellular protein localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • positive regulation of peptide hormone secretion   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular response to carbohydrate stimulus   • response to glucose   • positive regulation of protein localization   • insulin secretion involved in cellular response to glucose stimulus   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • positive regulation of secretion by cell   • hormone secretion   • protein localization to extracellular region   • positive regulation of protein transport   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • positive regulation of hormone secretion   • response to monosaccharide   • response to carbohydrate   • positive regulation of secretion   • signal release   • cellular response to hexose stimulus   • cellular response to monosaccharide stimulus   • positive regulation of cellular process   • positive regulation of peptide secretion   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • cellular response to glucose stimulus   • regulation of protein transport   • positive regulation of protein secretion   • peptide transport   • response to hexose   • positive regulation of transport   • regulation of cellular localization   • protein transport   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • regulation of insulin secretion involved in cellular response to glucose stimulus   • hormone transport   • regulation of cell communication   • insulin secretion   • positive regulation of signaling   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • cellular response to catecholamine stimulus   • serotonin receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-activating serotonin receptor signaling pathway   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • adenylate cyclase-activating dopamine receptor signaling pathway   • G protein-coupled dopamine receptor signaling pathway   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • renal system process   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • extracellular exosome   • extracellular vesicle   • extracellular organelle   • extracellular region   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • tetrapyrrole binding   • heme binding   • electron transfer activity   • transition metal ion binding   • iron ion binding   • G protein-coupled bile acid receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • electron transport chain   • metabolic process   • generation of precursor metabolites and energy   • energy homeostasis   • bicellular tight junction assembly   • regulation of bicellular tight junction assembly   • regulation of cellular component organization   • tight junction organization   • apical junction assembly   • regulation of cellular component biogenesis   • cellular component organization   • cellular component biogenesis   • regulation of cell junction assembly   • cell junction organization   • cellular component assembly   • cell junction assembly   • tight junction assembly   • cellular component organization or biogenesis   • cell-cell junction assembly   • cell-cell junction organization   • positive regulation of signal transduction   • regulation of signal transduction   • intracellular signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • intracellular signaling cassette   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • MAPK cascade   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • cholangiocyte proliferation   • positive regulation of cell population proliferation   • positive regulation of epithelial cell proliferation   • regulation of cholangiocyte proliferation   • regulation of cell population proliferation   • positive regulation of cholangiocyte proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • cellular response to bile acid   • response to bile acid   • periplasmic space   • receptor complex
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7BW0_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RATHRLLLL GAGESGKST 
IETKFQVDK VNFHMFDVG GQRDERRKW IQCFNDVTA IIFVVASSS 
YNMTNRLQE ALNLFKSIW NNRWLRTIS VILFLNKQD LLAEKVLAG 
KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF IRDEFLRIS 
TASGDGRHY CYPHFTCAV DTENIRRVF NDCRDIIQR MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7BW0_Chain_B
GSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7BW0_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TDU6
Sequence
>7BW0_Chain_R
PSPIPKGAL GLSLALASL IITANLLLA LGIAWDRRL RSPPAGCFF 
LSLLLAGLL TGLALPTLP GLWNQSRRG YWSCLLVYL APNFSFLSL 
LANLLLVHG ERYMAVLRP LQPPGSIRL ALLLTWAGP LLFASLPAL 
GWNHWTPGA NCSSPYLYL EVYGLLLPA VGAAAFLSV RVLATAHRQ 
LQDICRLER AVCRDEPSA LARALTWRQ ARAQAGAML LFGLCWGPY 
VATLLLSVL AYEQRPPLG PGTLLSLLS LGSASAAAV PVAMGLGDQ 
RYTAPWRAA A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7BW0ASteroidBile AcidGPBAHomo sapiens--chim(NtGi1-Gs)/β1/γ23.92020-09-02doi.org/10.1038/s41392-020-00262-z
7BW0 (No Gprot) ASteroidBile AcidGPBAHomo sapiens--3.92020-09-02doi.org/10.1038/s41392-020-00262-z
7CFMASteroidBile AcidGPBAHomo sapiensP395-Gs/β1/γ232020-09-09doi.org/10.1038/s41586-020-2569-1
7CFM (No Gprot) ASteroidBile AcidGPBAHomo sapiensP395-32020-09-09doi.org/10.1038/s41586-020-2569-1
7CFNASteroidBile AcidGPBAHomo sapiensINT-777-Gs/β1/γ232020-09-09doi.org/10.1038/s41586-020-2569-1
7CFN (No Gprot) ASteroidBile AcidGPBAHomo sapiensINT-777-32020-09-09doi.org/10.1038/s41586-020-2569-1
7XTQASteroidBile AcidGPBAHomo sapiensR399-Gs/β1/γ23.22022-07-06doi.org/10.1073/pnas.2117054119
7XTQ (No Gprot) ASteroidBile AcidGPBAHomo sapiensR399-3.22022-07-06doi.org/10.1073/pnas.2117054119
9GYOASteroidBile acidGPBAHomo sapiensP395-chim(NtGi1-Gs)/β1/γ22.52024-10-09doi.org/10.1038/s41598-025-16529-w
9GYO (No Gprot) ASteroidBile acidGPBAHomo sapiensP395-2.52024-10-09doi.org/10.1038/s41598-025-16529-w




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