Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:Y37 3.465414
2A:A:R42 5.955419
3A:A:L46 2.735418
4A:A:F219 4.8575408
5A:A:Q227 5.356519
6A:A:K233 4.19333619
7A:A:W234 3.85429719
8A:A:F238 6.5419
9A:A:A243 1.956548
10A:A:I244 2.205418
11A:A:I245 2.795407
12A:A:Y253 7.876538
13A:A:N254 9.4175439
14A:A:F273 6.195499
15A:A:W277 7.07696
16A:A:W281 7.5225405
17A:A:I288 2.7825449
18A:A:F290 3.3575409
19A:A:K293 6.9054159
20A:A:S306 6.6175437
21A:A:I308 4.11537
22A:A:F312 5.02738
23A:A:F315 9.57406
24A:A:Y318 5.58536
25A:A:E327 4.8975404
26A:A:F340 7.74143737
27A:A:F345 7.015408
28A:A:S349 3.1975497
29A:A:Y360 8.5448
30A:A:H362 6.87449
31A:A:R373 4.6275405
32A:A:D378 6.8725447
33A:A:I382 5.965446
34A:A:R385 7.054505
35B:B:L14 3.02508
36B:B:I18 4.5875477
37B:B:R22 8.075476
38B:B:H54 7.80167619
39B:B:W63 5.198527
40B:B:R68 7.4554185
41B:B:V71 2.1875408
42B:B:D76 4.43619
43B:B:K78 5.4825418
44B:B:I80 8418
45B:B:W82 7.2925819
46B:B:W99 5.24167619
47B:B:M101 5.245409
48B:B:Y105 2.57406
49B:B:N110 8.19254114
50B:B:C114 3.82408
51B:B:G115 2.3275409
52B:B:L117 3.732519
53B:B:C121 2.8475418
54B:B:Y124 5.402506
55B:B:E130 3.855403
56B:B:V133 3.8985194
57B:B:L139 7.5275419
58B:B:H142 5.34714719
59B:B:Y145 3.6718
60B:B:L146 3.7175417
61B:B:C148 2.8885106
62B:B:F151 7.615419
63B:B:T159 3.172519
64B:B:S160 3.5365106
65B:B:G162 2.7525419
66B:B:D163 5.674519
67B:B:W169 8.52667618
68B:B:F180 3.58833687
69B:B:H183 7.21409
70B:B:D186 3.748519
71B:B:F199 7.6175489
72B:B:C204 5.135417
73B:B:W211 7.028588
74B:B:H225 10.876519
75B:B:S227 4.8225416
76B:B:D228 4.77519
77B:B:F234 3.32405
78B:B:F235 6.23429716
79B:B:N237 10.72415
80B:B:N239 6.21412
81B:B:F241 4.598516
82B:B:T243 5.405418
83B:B:G244 2.76415
84B:B:S245 5.33519
85B:B:D247 6.416519
86B:B:T249 7.5125416
87B:B:C250 3.0075418
88B:B:R251 12.068518
89B:B:F253 4.438516
90B:B:D254 3.82519
91B:B:R256 8.022519
92B:B:Y264 9.475405
93B:B:I269 5.6825404
94B:B:C271 4.79415
95B:B:I273 5.4475416
96B:B:T274 2.695458
97B:B:S275 3.16408
98B:B:V276 2.5925416
99B:B:F278 4.295617
100B:B:S281 2.695409
101B:B:R283 4.8525469
102B:B:A287 2.3375416
103B:B:Y289 6.586517
104B:B:N295 5.24516
105B:B:W297 8.4475418
106B:B:D298 3.8225469
107B:B:L300 4.17333666
108B:B:K301 3.9575465
109B:B:H311 8.06559
110B:B:R314 9.835408
111B:B:V315 3.0975457
112B:B:L318 3.705406
113B:B:T321 5.545427
114B:B:T329 4.4125458
115B:B:W332 8.404519
116B:B:D333 6.715459
117B:B:K337 6.298556
118B:B:W339 7.946559
119B:B:N340 7.18529
120G:G:Q18 8.83409
121G:G:R27 5.4875478
122G:G:V30 3.4575408
123G:G:M38 1.85404
124G:G:H44 10.945406
125G:G:D48 5.05833609
126G:G:L51 3.48406
127G:G:V54 3.585426
128G:G:N59 4.488529
129G:G:P60 6.8375429
130G:G:F61 4.87857728
131R:R:I28 2.30754218
132R:R:N32 4.5525229
133R:R:G61 1.8754229
134R:R:G65 2.2054219
135R:R:L68 4.61406
136R:R:C85 4.2154139
137R:R:Y89 2.2275405
138R:R:S95 2.82754245
139R:R:N102 5.14254128
140R:R:H107 5.4525409
141R:R:E109 4.6775409
142R:R:Q119 3.72254145
143R:R:P135 3.025408
144R:R:P142 3.58754258
145R:R:F233 4.8925409
146R:R:W237 6.936508
147R:R:Y240 7.6885267
148R:R:P255 2.9404
149R:R:P277 2.4225229
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1B:B:Q75 B:B:W99 12.61752.19NoYes099
2A:A:F238 B:B:W99 20.772511.02YesYes199
3A:A:F238 A:A:L44 1008.53YesNo199
4A:A:L44 A:A:L46 99.29214.15NoYes198
5A:A:F246 A:A:L46 99.23923.65NoYes098
6A:A:A269 A:A:F246 98.85532.77NoNo099
7A:A:A269 A:A:V248 97.42741.7NoNo097
8A:A:L266 A:A:V248 97.2961.49NoNo087
9A:A:L266 A:A:Y253 90.70012.34NoYes088
10A:A:K300 A:A:Y253 76.6234.78NoYes398
11A:A:K300 A:A:L296 76.69055.64NoNo096
12A:A:L296 A:A:S251 76.52249.01NoNo069
13A:A:K293 A:A:S251 76.35417.65YesNo099
14A:A:A249 A:A:K293 75.80133.21NoYes1589
15A:A:A249 A:A:S51 75.67823.42NoNo089
16A:A:S51 A:A:V247 75.50861.62NoNo097
17A:A:I245 A:A:V247 75.33871.54YesNo077
18A:A:F290 A:A:H362 35.56624.53YesYes099
19A:A:F290 A:A:I245 67.98422.51YesYes097
20A:A:F238 A:A:W234 39.85964.01YesYes199
21B:B:M101 B:B:Y145 23.53584.79YesYes098
22B:B:L117 B:B:Y145 41.20132.34YesYes198
23A:A:K233 B:B:Y145 57.26622.39YesYes198
24A:A:K233 B:B:D228 59.17915.53YesYes199
25A:A:F290 A:A:I288 32.07133.77YesYes099
26A:A:I308 A:A:Y253 21.47318.46YesYes378
27A:A:F345 A:A:L266 10.05792.44YesNo088
28A:A:D378 A:A:I288 32.69242.8YesYes479
29A:A:D378 A:A:H362 31.809315.13YesYes479
30A:A:D331 A:A:V334 10.49415.84NoNo044
31A:A:D331 A:A:R333 11.98914.76NoNo045
32A:A:R333 A:A:R336 12.736213.86NoNo055
33A:A:F340 A:A:I308 13.56952.51YesYes377
34A:A:D378 A:A:D381 64.12532.66YesNo478
35A:A:D381 A:A:Q384 63.26042.61NoNo486
36A:A:Q384 R:R:V114 63.04192.87NoNo068
37R:R:L115 R:R:V114 57.06172.98NoNo068
38R:R:L115 R:R:Y111 55.773611.72NoNo069
39R:R:V188 R:R:Y111 53.62142.52NoNo099
40A:A:L393 R:R:V188 50.59721.49NoNo089
41A:A:L393 R:R:R110 50.16423.64NoNo089
42A:A:Y391 R:R:R110 14.3977.2NoNo049
43A:A:Y391 R:R:E109 13.49885.61NoYes049
44B:B:G116 B:B:M101 24.76621.75NoYes099
45B:B:G115 B:B:G116 24.59432.11YesNo099
46B:B:G115 B:B:T102 24.39661.82YesNo098
47B:B:C148 B:B:T102 24.48643.38YesNo068
48B:B:H183 B:B:V187 10.04964.15YesNo099
49B:B:C218 G:G:Q18 16.34839.16NoYes059
50G:G:E22 G:G:Q18 11.689115.29NoYes099
51G:G:E22 G:G:L19 10.1342.65NoNo099
52B:B:C148 B:B:S160 18.29411.72YesYes1066
53B:B:L255 B:B:N239 14.13634.12NoYes162
54B:B:D254 B:B:L255 13.65252.71YesNo196
55B:B:A257 B:B:D254 12.6984.63NoYes079
56B:B:A257 G:G:V30 11.72281.7NoYes078
57B:B:Q259 G:G:V30 19.54045.73NoYes068
58B:B:Q259 B:B:R22 15.63442.34NoYes066
59B:B:N239 B:B:R256 17.548510.85YesYes129
60B:B:D254 B:B:R256 13.67415.96YesYes199
61B:B:D254 B:B:L261 12.6982.71YesNo095
62B:B:L261 G:G:V30 11.72282.98NoYes058
63B:B:L30 B:B:M262 13.82324.24NoNo054
64B:B:H142 B:B:W169 10.0192.12YesYes198
65B:B:G162 B:B:Y145 11.2235.79YesYes198
66B:B:F234 B:B:G238 27.02313.01YesNo057
67B:B:D228 B:B:S227 59.16662.94YesYes196
68B:B:S227 B:B:S245 40.31581.63YesYes169
69B:B:H225 B:B:S245 18.726515.34YesYes199
70B:B:H225 B:B:T243 32.92648.21YesYes198
71B:B:F241 B:B:T243 29.4842.59YesYes168
72B:B:D247 B:B:S227 20.502211.78YesYes196
73B:B:D247 B:B:H225 18.11355.04YesYes199
74B:B:F234 B:B:F241 28.90012.14YesYes056
75B:B:G244 B:B:S245 22.62553.71YesYes159
76B:B:M262 B:B:Y264 14.55577.18NoYes045
77B:B:W297 B:B:Y264 16.252222.19YesYes085
78R:R:H107 R:R:R110 35.4535.64YesNo099
79R:R:H107 R:R:L103 34.12866.43YesNo099
80R:R:L103 R:R:W237 33.68923.42NoYes098
81R:R:V276 R:R:W237 19.905711.03NoYes098
82R:R:P277 R:R:V276 18.69873.53YesNo099
83R:R:G61 R:R:P277 13.27522.03YesYes2299
84R:R:G61 R:R:T64 12.39861.82YesNo098
85R:R:E109 R:R:F53 11.2777YesNo098
86R:R:F53 R:R:L105 10.838110.96NoNo086
87A:A:W234 B:B:Y145 39.5921.93YesYes198
88B:B:A287 B:B:W297 11.93142.59YesYes168
89B:B:G238 B:B:N239 24.42851.7NoYes172
90A:A:F238 B:B:L117 39.60172.44YesYes199
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7BW0
Class A
SubFamily Steroid
Type Bile acid
SubType GPBA
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners chim(NtGi1-Gs)/Beta1/Gamma2
PDB Resolution 3.9
Date 2020-09-02
D.O.I. 10.1038/s41392-020-00262-z
Net Summary
Imin 1.62
Number of Linked Nodes 831
Number of Links 996
Number of Hubs 149
Number of Links mediated by Hubs 533
Number of Communities 26
Number of Nodes involved in Communities 214
Number of Links involved in Communities 303
Path Summary
Number Of Nodes in MetaPath 91
Number Of Links MetaPath 90
Number of Shortest Paths 1203035
Length Of Smallest Path 3
Average Path Length 30.2719
Length of Longest Path 62
Minimum Path Strength 1.085
Average Path Strength 4.70112
Maximum Path Strength 24.075
Minimum Path Correlation 0.7
Average Path Correlation 0.983614
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.32558
Average % Of Corr. Nodes 48.5475
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 48.1428
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier
SCOP2Family Identifier
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7BW0_Chain_A
TLSAEDKAA VERSKMIEK QLQKDKQVY RATHRLLLL GAGESGKST 
IETKFQVDK VNFHMFDVG GQRDERRKW IQCFNDVTA IIFVVASSS 
YNMTNRLQE ALNLFKSIW NNRWLRTIS VILFLNKQD LLAEKVLAG 
KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF IRDEFLRIS 
TASGDGRHY CYPHFTCAV DTENIRRVF NDCRDIIQR MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP54311
Sequence
>7BW0_Chain_B
GSELDQLRQ EAEQLKNQI RDARKACAD ATLSQITNN IDPVGRIQM 
RTRRTLRGH LAKIYAMHW GTDSRLLVS ASQDGKLII WDSYTTNKV 
HAIPLRSSW VMTCAYAPS GNYVACGGL DNICSIYNL KTREGNVRV 
SRELAGHTG YLSCCRFLD DNQIVTSSG DTTCALWDI ETGQQTTTF 
TGHTGDVMS LSLAPDTRL FVSGACDAS AKLWDVREG MCRQTFTGH 
ESDINAICF FPNGNAFAT GSDDATCRL FDLRADQEL MTYSHDNII 
CGITSVSFS KSGRLLLAG YDDFNCNVW DALKADRAG VLAGHDNRV 
SCLGVTDDG MAVATGSWD SFLKIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP63212
Sequence
>7BW0_Chain_G
NTASIAQAR KLVEQLKME ANIDRIKVS KAAADLMAY CEAHAKEDP 
LLTPVPASE NPFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtQ8TDU6
Sequence
>7BW0_Chain_R
PSPIPKGAL GLSLALASL IITANLLLA LGIAWDRRL RSPPAGCFF 
LSLLLAGLL TGLALPTLP GLWNQSRRG YWSCLLVYL APNFSFLSL 
LANLLLVHG ERYMAVLRP LQPPGSIRL ALLLTWAGP LLFASLPAL 
GWNHWTPGA NCSSPYLYL EVYGLLLPA VGAAAFLSV RVLATAHRQ 
LQDICRLER AVCRDEPSA LARALTWRQ ARAQAGAML LFGLCWGPY 
VATLLLSVL AYEQRPPLG PGTLLSLLS LGSASAAAV PVAMGLGDQ 
RYTAPWRAA A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7BW0ASteroidBile acidGPBAHomo sapiens--chim(NtGi1-Gs)/&β;1/&γ;23.92020-09-0210.1038/s41392-020-00262-z
7CFMASteroidBile acidGPBAHomo sapiensP395-Gs/&β;1/&γ;232020-09-0910.1038/s41586-020-2569-1
7CFNASteroidBile acidGPBAHomo sapiensINT-777-Gs/&β;1/&γ;232020-09-0910.1038/s41586-020-2569-1
7XTQASteroidBile acidGPBAHomo sapiensR399-Gs/&β;1/&γ;23.22022-07-0610.1073/pnas.2117054119




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7BW0.zip



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