psnGPCR

Press and hold down the left mouse button and move the mouse to rotate.
Press and hold down the central mouse button and move the mouse to translate.
Use the mouse wheel to zoom in or out.
Click on any atom on your molecule and the corresponding residue label will be placed beneath the viewer.

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L71	3.95	Yes	Yes	0	0	7
2	L:L:?1	R:R:L74	6.58	Yes	No	0	0	5
3	L:L:?1	R:R:N93	6.52	Yes	No	1	0	6
4	L:L:?1	R:R:F96	12.73	Yes	Yes	1	0	6
5	L:L:?1	R:R:S157	8.56	Yes	No	0	0	5
6	L:L:?1	R:R:F161	3.47	Yes	No	1	0	5
7	L:L:?1	R:R:L166	3.95	Yes	No	0	0	5
8	L:L:?1	R:R:E169	8.81	Yes	Yes	1	0	6
9	L:L:?1	R:R:Y240	4.46	Yes	Yes	1	0	7
10	L:L:?1	R:R:L244	5.26	Yes	No	0	0	5
11	L:L:?1	R:R:S247	7.13	Yes	No	0	0	5
12	L:L:?1	R:R:L266	3.95	Yes	No	0	0	7
13	R:R:L18	R:R:P72	3.28	No	Yes	0	3	6
14	R:R:L68	R:R:S21	3	Yes	No	0	6	7
15	R:R:P72	R:R:S21	3.56	Yes	No	0	6	7
16	R:R:S21	R:R:S267	3.26	No	No	0	7	6
17	R:R:L22	R:R:P69	4.93	No	No	0	3	9
18	R:R:A25	R:R:L68	3.15	No	Yes	5	7	6
19	R:R:A25	R:R:P69	3.74	No	No	5	7	9
20	R:R:I28	R:R:N32	2.83	No	No	0	8	9
21	R:R:A274	R:R:I28	3.25	No	No	0	8	8
22	R:R:I29	R:R:L62	5.71	No	No	0	6	6
23	R:R:I29	R:R:L66	4.28	No	No	0	6	5
24	R:R:L58	R:R:N32	4.12	No	No	0	9	9
25	R:R:L33	R:R:L62	4.15	No	No	0	5	6
26	R:R:L35	R:R:L58	4.15	No	No	0	9	9
27	R:R:G38	R:R:W291	4.22	No	No	0	8	6
28	R:R:I39	R:R:L55	2.85	No	No	0	8	7
29	R:R:I39	R:R:Y287	4.84	No	Yes	0	8	7
30	R:R:D42	R:R:W41	4.47	Yes	No	0	7	4
31	R:R:D42	R:R:R44	3.57	Yes	No	2	7	6
32	R:R:D42	R:R:L45	8.14	Yes	No	2	7	8
33	R:R:R43	R:R:S47	7.91	No	No	0	7	7
34	R:R:L45	R:R:R44	7.29	No	No	2	8	6
35	R:R:L45	R:R:Y287	4.69	No	Yes	2	8	7
36	R:R:E109	R:R:P49	3.14	Yes	No	0	9	7
37	R:R:C52	R:R:I124	4.91	No	Yes	0	3	6
38	R:R:F53	R:R:L105	18.27	Yes	No	0	8	6
39	R:R:E109	R:R:F53	5.83	Yes	Yes	0	9	8
40	R:R:F53	R:R:I124	5.02	Yes	Yes	3	8	6
41	R:R:F53	R:R:L128	6.09	Yes	No	3	8	7
42	R:R:F54	R:R:L58	7.31	No	No	0	8	9
43	R:R:F54	R:R:G281	3.01	No	No	0	8	7
44	R:R:F54	R:R:Y287	8.25	No	Yes	0	8	7
45	R:R:N102	R:R:S56	7.45	Yes	No	3	8	9
46	R:R:L128	R:R:S56	3	No	No	3	7	9
47	R:R:S56	R:R:W132	6.18	No	Yes	3	9	9
48	R:R:L57	R:R:V106	2.98	No	No	0	9	9
49	R:R:L57	R:R:P277	4.93	No	No	0	9	9
50	R:R:L59	R:R:W132	5.69	No	Yes	0	7	9
51	R:R:A60	R:R:L99	3.15	No	No	0	9	9
52	R:R:A60	R:R:N102	4.69	No	Yes	0	9	8
53	R:R:G61	R:R:T64	3.64	No	Yes	0	9	8
54	R:R:L63	R:R:S95	7.51	No	No	0	6	5
55	R:R:S95	R:R:T64	4.8	No	Yes	0	5	8
56	R:R:F96	R:R:T64	5.19	Yes	Yes	0	6	8
57	R:R:L99	R:R:T64	8.84	No	Yes	0	9	8
58	R:R:A274	R:R:T64	3.36	No	Yes	0	8	8
59	R:R:A67	R:R:S95	3.42	No	No	0	7	5
60	R:R:L68	R:R:P69	3.28	Yes	No	5	6	9
61	R:R:L71	R:R:S270	3	Yes	No	0	7	8
62	R:R:L74	R:R:Q77	5.32	No	No	0	5	4
63	R:R:N76	R:R:W75	4.52	No	No	0	3	4
64	R:R:N76	R:R:S78	2.98	No	No	0	3	3
65	R:R:Q77	R:R:R80	10.51	No	No	0	4	4
66	R:R:Q77	R:R:V88	10.03	No	No	0	4	5
67	R:R:N154	R:R:S78	5.96	No	No	0	3	3
68	R:R:R80	R:R:S84	3.95	No	No	0	4	3
69	R:R:W83	R:R:Y82	6.75	No	Yes	0	1	4
70	R:R:L86	R:R:Y82	4.69	Yes	Yes	0	6	4
71	R:R:N147	R:R:Y82	8.14	No	Yes	0	8	4
72	R:R:W149	R:R:Y82	24.12	No	Yes	0	3	4
73	R:R:C155	R:R:C85	7.28	No	No	0	9	9
74	R:R:L86	R:R:L90	5.54	Yes	No	0	6	5
75	R:R:A143	R:R:L86	4.73	No	Yes	0	6	6
76	R:R:I160	R:R:L86	4.28	No	Yes	0	5	6
77	R:R:S157	R:R:Y89	10.17	No	Yes	0	5	5
78	R:R:I160	R:R:Y89	8.46	No	Yes	1	5	5
79	R:R:F161	R:R:Y89	4.13	No	Yes	1	5	5
80	R:R:N93	R:R:Y165	4.65	No	Yes	1	6	7
81	R:R:E169	R:R:N93	11.83	Yes	No	1	6	6
82	R:R:F94	R:R:P135	2.89	No	Yes	0	5	8
83	R:R:F94	R:R:L136	3.65	No	No	0	5	5
84	R:R:A139	R:R:F94	4.16	No	No	0	7	5
85	R:R:F96	R:R:Y240	6.19	Yes	Yes	1	6	7
86	R:R:F96	R:R:S270	3.96	Yes	No	0	6	8
87	R:R:L97	R:R:P135	3.28	No	Yes	0	7	8
88	R:R:E169	R:R:L97	6.63	Yes	No	0	6	7
89	R:R:S98	R:R:W132	6.18	No	Yes	0	7	9
90	R:R:L99	R:R:P277	3.28	No	No	0	9	9
91	R:R:L100	R:R:W237	6.83	No	Yes	0	8	8
92	R:R:A101	R:R:P135	3.74	No	Yes	0	5	8
93	R:R:N102	R:R:T131	4.39	Yes	No	0	8	6
94	R:R:N102	R:R:W132	14.69	Yes	Yes	3	8	9
95	R:R:H107	R:R:L103	5.14	Yes	No	6	9	9
96	R:R:L103	R:R:W237	3.42	No	Yes	0	9	8
97	R:R:L103	R:R:M280	2.83	No	Yes	6	9	8
98	R:R:L105	R:R:T131	11.79	No	No	0	6	6
99	R:R:H107	R:R:R110	3.39	Yes	No	0	9	9
100	R:R:H107	R:R:M280	3.94	Yes	Yes	6	9	8
101	R:R:R110	R:R:V188	3.92	No	No	0	9	9
102	R:R:L115	R:R:Y111	10.55	Yes	No	7	6	9
103	R:R:L184	R:R:Y111	14.07	No	No	0	7	9
104	R:R:R187	R:R:Y111	5.14	No	No	7	6	9
105	R:R:M112	R:R:R116	4.96	No	No	0	5	5
106	R:R:L115	R:R:V114	2.98	Yes	No	0	6	8
107	R:R:L115	R:R:R187	6.07	Yes	No	7	6	6
108	R:R:L115	R:R:V188	2.98	Yes	No	0	6	9
109	R:R:L115	R:R:T191	7.37	Yes	No	0	6	6
110	R:R:Q119	R:R:R116	7.01	No	No	0	5	5
111	R:R:P120	R:R:Q119	3.16	No	No	0	8	5
112	R:R:I124	R:R:R125	5.01	Yes	No	0	6	1
113	R:R:I124	R:R:L128	2.85	Yes	No	3	6	7
114	R:R:L126	R:R:L130	5.54	No	No	0	3	2
115	R:R:G134	R:R:P135	4.06	No	Yes	0	2	8
116	R:R:F138	R:R:Y165	14.44	Yes	Yes	1	5	7
117	R:R:E169	R:R:F138	8.16	Yes	Yes	1	6	5
118	R:R:F138	R:R:L173	7.31	Yes	No	0	5	4
119	R:R:L141	R:R:P142	3.28	No	No	1	5	8
120	R:R:L141	R:R:W146	9.11	No	No	0	5	6
121	R:R:L141	R:R:Y165	3.52	No	Yes	1	5	7
122	R:R:P142	R:R:Y165	12.52	No	Yes	1	8	7
123	R:R:G145	R:R:L144	5.13	No	No	0	7	4
124	R:R:P162	R:R:W146	5.4	Yes	No	0	5	6
125	R:R:H148	R:R:P162	3.05	No	Yes	0	4	5
126	R:R:G152	R:R:W149	7.04	No	No	0	1	3
127	R:R:P151	R:R:T150	3.5	No	No	0	2	3
128	R:R:N154	R:R:S156	2.98	No	No	0	3	4
129	R:R:Q158	R:R:Y251	3.38	No	No	0	3	4
130	R:R:F161	R:R:I160	3.77	No	No	1	5	5
131	R:R:P162	R:R:Y165	4.17	Yes	Yes	0	5	7
132	R:R:E169	R:R:Y165	3.37	Yes	Yes	1	6	7
133	R:R:L166	R:R:Y251	8.21	No	No	0	5	4
134	R:R:Y167	R:R:Y171	6.95	No	Yes	4	6	5
135	R:R:V248	R:R:Y167	3.79	No	No	4	6	6
136	R:R:E252	R:R:Y167	10.1	No	No	0	1	6
137	R:R:E169	R:R:L174	3.98	Yes	No	0	6	7
138	R:R:V170	R:R:Y171	5.05	No	Yes	4	4	5
139	R:R:L244	R:R:V170	4.47	No	No	0	5	4
140	R:R:V170	R:R:V248	4.81	No	No	4	4	6
141	R:R:L245	R:R:Y171	3.52	No	Yes	0	5	5
142	R:R:V248	R:R:Y171	5.05	No	Yes	4	6	5
143	R:R:G172	R:R:P176	4.06	No	No	0	4	3
144	R:R:L174	R:R:L244	5.54	No	No	0	7	5
145	R:R:L175	R:R:V241	4.47	No	No	0	6	6
146	R:R:V178	R:R:W237	3.68	No	Yes	0	7	8
147	R:R:F183	R:R:L184	3.65	No	No	0	3	7
148	R:R:L189	R:R:Q226	7.99	No	No	0	7	7
149	R:R:A192	R:R:Q222	3.03	No	No	0	9	7
150	R:R:H193	R:R:Q197	8.65	No	No	0	7	6
151	R:R:C200	R:R:L196	3.17	No	Yes	0	4	5
152	R:R:L196	R:R:L218	4.15	Yes	Yes	0	5	6
153	R:R:L196	R:R:T219	2.95	Yes	No	0	5	7
154	R:R:L196	R:R:Q222	13.31	Yes	No	0	5	7
155	R:R:D198	R:R:R201	5.96	No	No	0	6	5
156	R:R:E203	R:R:S212	12.94	No	No	0	3	3
157	R:R:E203	R:R:L214	6.63	No	No	0	3	3
158	R:R:D209	R:R:E210	3.9	No	No	0	1	2
159	R:R:P211	R:R:R216	5.76	No	No	0	3	3
160	R:R:L214	R:R:L218	6.92	No	Yes	0	3	6
161	R:R:L232	R:R:M280	4.24	No	Yes	0	6	8
162	R:R:F233	R:R:W237	4.01	No	Yes	0	9	8
163	R:R:C236	R:R:V276	3.42	No	Yes	0	8	9
164	R:R:W237	R:R:Y240	6.75	Yes	Yes	0	8	7
165	R:R:V276	R:R:W237	12.26	Yes	Yes	0	9	8
166	R:R:G238	R:R:P239	4.06	No	No	0	6	9
167	R:R:A273	R:R:Y240	4	No	Yes	0	9	7
168	R:R:G269	R:R:T243	5.46	No	No	0	9	5
169	R:R:L246	R:R:L262	5.54	No	No	0	5	2
170	R:R:L249	R:R:R254	3.64	No	No	0	4	1
171	R:R:E252	R:R:Y251	4.49	No	No	0	1	4
172	R:R:G258	R:R:P259	4.06	No	No	0	4	5
173	R:R:P277	R:R:V276	3.53	No	Yes	0	9	9
174	R:R:M280	R:R:V276	3.04	Yes	Yes	0	8	9
175	R:R:D284	R:R:R286	13.1	No	No	2	8	5
176	R:R:D284	R:R:Y287	13.79	No	Yes	2	8	7
177	R:R:R286	R:R:Y287	14.4	No	Yes	2	5	7
178	R:R:H107	R:R:S185	2.79	Yes	No	0	9	9
179	R:R:L20	R:R:L24	2.77	No	No	0	4	7
180	R:R:A127	R:R:F53	2.77	No	Yes	0	5	8
181	R:R:A181	R:R:F233	2.77	No	No	0	8	9
182	R:R:A182	R:R:F233	2.77	No	No	0	5	9
183	R:R:L231	R:R:L235	2.77	No	No	0	5	4
184	R:R:L246	R:R:L265	2.77	No	No	0	5	7
185	R:R:C85	R:R:Y89	2.69	No	Yes	0	9	5
186	R:R:H193	R:R:Q222	2.47	No	No	0	7	7
187	R:R:F138	R:R:L168	2.44	Yes	No	0	5	6
188	R:R:L175	R:R:Y171	2.34	No	Yes	0	6	5
189	R:R:Q195	R:R:R194	2.34	No	No	0	8	5
190	R:R:L34	R:R:W291	2.28	No	No	0	7	6
191	R:R:R43	R:R:R46	2.13	No	No	0	7	8
192	R:R:G73	R:R:P72	2.03	No	Yes	0	2	6
193	R:R:G260	R:R:P259	2.03	No	No	0	1	5
194	R:R:P48	R:R:P49	1.95	No	No	0	3	7
195	R:R:A50	R:R:G51	1.95	No	No	0	8	8
196	R:R:P120	R:R:P121	1.95	No	No	0	8	3
197	R:R:P162	R:R:P164	1.95	Yes	No	0	5	4
198	R:R:P255	R:R:P256	1.95	No	No	0	4	4
199	R:R:A91	R:R:P92	1.87	No	No	0	3	6
200	R:R:A163	R:R:P164	1.87	No	No	0	4	4
201	R:R:A289	R:R:P290	1.87	No	No	0	4	6
202	R:R:G81	R:R:S84	1.86	No	No	0	5	3
203	R:R:G269	R:R:S272	1.86	No	No	0	9	9
204	R:R:A215	R:R:C200	1.81	No	No	0	4	4
205	R:R:P48	R:R:S47	1.78	No	No	0	3	7
206	R:R:P239	R:R:S272	1.78	No	No	0	9	9
207	R:R:C236	R:R:S272	1.72	No	No	0	8	9
208	R:R:G19	R:R:L18	1.71	No	No	0	4	3
209	R:R:G19	R:R:L22	1.71	No	No	0	4	3
210	R:R:G65	R:R:L68	1.71	No	Yes	0	9	6
211	R:R:G108	R:R:L184	1.71	No	No	0	6	7
212	R:R:A143	R:R:S140	1.71	No	No	0	6	5
213	R:R:A229	R:R:S185	1.71	No	No	0	8	9
214	R:R:C207	R:R:V206	1.71	No	No	0	4	4
215	R:R:A31	R:R:V278	1.7	No	No	0	8	6
216	R:R:A275	R:R:V278	1.7	No	No	0	6	6
217	R:R:L71	R:R:P72	1.64	Yes	Yes	0	7	6
218	R:R:L71	R:R:P92	1.64	Yes	No	0	7	6
219	R:R:L263	R:R:P72	1.64	No	Yes	0	5	6
220	R:R:L175	R:R:P176	1.64	No	No	0	6	3
221	R:R:L262	R:R:P255	1.64	No	No	0	2	4
222	R:R:L257	R:R:P256	1.64	No	No	0	1	4
223	R:R:A275	R:R:I28	1.62	No	No	0	6	8
224	R:R:D42	R:R:P290	1.61	Yes	No	0	7	6
225	R:R:S26	R:R:T30	1.6	No	No	0	4	2
226	R:R:T70	R:R:V88	1.59	No	No	0	4	5
227	R:R:A36	R:R:L55	1.58	No	No	0	8	7
228	R:R:A271	R:R:L68	1.58	No	Yes	0	6	6
229	R:R:A177	R:R:L100	1.58	No	No	0	8	8
230	R:R:A177	R:R:L104	1.58	No	No	0	8	7
231	R:R:A180	R:R:L104	1.58	No	No	0	5	7
232	R:R:A229	R:R:L189	1.58	No	No	0	8	7
233	R:R:A250	R:R:L262	1.58	No	No	0	4	2
234	R:R:E210	R:R:P211	1.57	No	No	0	2	3
235	R:R:A50	R:R:E109	1.51	No	Yes	0	8	9
236	R:R:A113	R:R:E109	1.51	No	Yes	0	9	9
237	R:R:L282	R:R:V278	1.49	No	No	0	6	6
238	R:R:L265	R:R:T243	1.47	No	No	0	7	5
239	R:R:P117	R:R:R116	1.44	No	No	0	9	5
240	R:R:P255	R:R:R254	1.44	No	No	0	4	1
241	R:R:I199	R:R:L218	1.43	No	Yes	0	7	6
242	R:R:E203	R:R:V206	1.43	No	No	0	3	4
243	R:R:G73	R:R:W75	1.41	No	No	0	2	4
244	R:R:L24	R:R:L68	1.38	No	Yes	0	7	6
245	R:R:L62	R:R:N32	1.37	No	No	0	6	9
246	R:R:R79	R:R:S78	1.32	No	No	0	3	3
247	R:R:R125	R:R:S123	1.32	No	No	0	1	6
248	R:R:D198	R:R:Q195	1.31	No	No	0	6	8
249	R:R:R194	R:R:T191	1.29	No	No	0	5	6
250	R:R:Q158	R:R:Q253	1.28	No	No	0	3	2
251	R:R:H193	R:R:Q226	1.24	No	No	0	7	7
252	R:R:L218	R:R:R221	1.21	Yes	No	0	6	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	6.28083	12	1	0
2	R:R:D42	4.4475	4	2	7
3	R:R:F53	7.596	5	3	8
4	R:R:T64	5.166	5	0	8
5	R:R:L68	2.35	6	5	6
6	R:R:L71	2.5575	4	0	7
7	R:R:P72	2.43	5	0	6
8	R:R:Y82	10.925	4	0	4
9	R:R:L86	4.81	4	0	6
10	R:R:Y89	6.3625	4	1	5
11	R:R:F96	7.0175	4	1	6
12	R:R:N102	7.805	4	3	8
13	R:R:H107	3.815	4	6	9
14	R:R:E109	2.9975	4	0	9
15	R:R:L115	5.99	5	7	6
16	R:R:I124	4.4475	4	3	6
17	R:R:W132	8.185	4	3	9
18	R:R:P135	3.4925	4	0	8
19	R:R:F138	8.0875	4	1	5
20	R:R:P162	3.6425	4	0	5
21	R:R:Y165	7.11167	6	1	7
22	R:R:E169	7.13	6	1	6
23	R:R:Y171	4.582	5	4	5
24	R:R:L196	5.895	4	0	5
25	R:R:L218	3.4275	4	0	6
26	R:R:W237	6.15833	6	0	8
27	R:R:Y240	5.35	4	1	7
28	R:R:V276	5.5625	4	0	9
29	R:R:M280	3.5125	4	6	8
30	R:R:Y287	9.194	5	2	7

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L71	50.0472	3.95	Yes	Yes	0	0	7
2	R:R:L71	R:R:P72	58.4781	1.64	Yes	Yes	0	7	6
3	R:R:P72	R:R:S21	25.9158	3.56	Yes	No	0	6	7
4	R:R:L68	R:R:S21	20.2889	3	Yes	No	0	6	7
5	L:L:?1	R:R:F96	69.2409	12.73	Yes	Yes	1	0	6
6	R:R:F96	R:R:T64	100	5.19	Yes	Yes	0	6	8
7	R:R:A274	R:R:T64	69.071	3.36	No	Yes	0	8	8
8	R:R:A274	R:R:I28	66.7579	3.25	No	No	0	8	8
9	R:R:I28	R:R:N32	54.9094	2.83	No	No	0	8	9
10	R:R:L62	R:R:N32	11.0933	1.37	No	No	0	6	9
11	R:R:L58	R:R:N32	42.5887	4.12	No	No	0	9	9
12	R:R:F54	R:R:L58	37.5283	7.31	No	No	0	8	9
13	R:R:F54	R:R:Y287	32.3924	8.25	No	Yes	0	8	7
14	R:R:L45	R:R:Y287	16.5313	4.69	No	Yes	2	8	7
15	R:R:D42	R:R:L45	11.0555	8.14	Yes	No	2	7	8
16	R:R:L99	R:R:T64	75.2266	8.84	No	Yes	0	9	8
17	R:R:A60	R:R:L99	75.6609	3.15	No	No	0	9	9
18	R:R:A60	R:R:N102	73.8199	4.69	No	Yes	0	9	8
19	R:R:N102	R:R:S56	37.094	7.45	Yes	No	3	8	9
20	R:R:L128	R:R:S56	35.5079	3	No	No	3	7	9
21	R:R:F53	R:R:L128	24.5279	6.09	Yes	No	3	8	7
22	R:R:E109	R:R:F53	40.3512	5.83	Yes	Yes	0	9	8
23	R:R:E109	R:R:P49	22.602	3.14	Yes	No	0	9	7
24	R:R:P48	R:R:P49	18.1174	1.95	No	No	0	3	7
25	R:R:P48	R:R:S47	13.614	1.78	No	No	0	3	7
26	R:R:N102	R:R:T131	28.4271	4.39	Yes	No	0	8	6
27	R:R:L105	R:R:T131	26.3595	11.79	No	No	0	6	6
28	R:R:F53	R:R:L105	24.2919	18.27	Yes	No	0	8	6
29	R:R:L99	R:R:P277	43.2779	3.28	No	No	0	9	9
30	L:L:?1	R:R:Y240	66.4936	4.46	Yes	Yes	1	0	7
31	R:R:W237	R:R:Y240	80.8346	6.75	Yes	Yes	0	8	7
32	R:R:V276	R:R:W237	26.114	12.26	Yes	Yes	0	9	8
33	R:R:P277	R:R:V276	42.4849	3.53	No	Yes	0	9	9
34	R:R:F96	R:R:S270	18.344	3.96	Yes	No	0	6	8
35	L:L:?1	R:R:L74	15.5589	6.58	Yes	No	0	0	5
36	R:R:L74	R:R:Q77	13.5291	5.32	No	No	0	5	4
37	R:R:G73	R:R:P72	20.4116	2.03	No	Yes	0	2	6
38	R:R:G73	R:R:W75	17.551	1.41	No	No	0	2	4
39	R:R:N76	R:R:W75	14.6715	4.52	No	No	0	3	4
40	R:R:N76	R:R:S78	11.773	2.98	No	No	0	3	3
41	L:L:?1	R:R:F161	29.7205	3.47	Yes	No	1	0	5
42	R:R:F161	R:R:I160	21.5162	3.77	No	No	1	5	5
43	R:R:I160	R:R:L86	19.7885	4.28	No	Yes	0	5	6
44	R:R:L86	R:R:Y82	11.1782	4.69	Yes	Yes	0	6	4
45	L:L:?1	R:R:E169	41.6446	8.81	Yes	Yes	1	0	6
46	R:R:E169	R:R:Y165	19.7885	3.37	Yes	Yes	1	6	7
47	R:R:E169	R:R:L97	15.6439	6.63	Yes	No	0	6	7
48	R:R:L97	R:R:P135	13.5857	3.28	No	Yes	0	7	8
49	R:R:L103	R:R:W237	52.1809	3.42	No	Yes	0	9	8
50	R:R:H107	R:R:L103	48.4611	5.14	Yes	No	6	9	9
51	R:R:M280	R:R:V276	33.0532	3.04	Yes	Yes	0	8	9
52	R:R:H107	R:R:R110	33.9596	3.39	Yes	No	0	9	9
53	R:R:R110	R:R:V188	31.656	3.92	No	No	0	9	9
54	R:R:L115	R:R:V188	29.3335	2.98	Yes	No	0	6	9
55	R:R:L115	R:R:Y111	10.0359	10.55	Yes	No	7	6	9
56	R:R:L115	R:R:T191	12.5378	7.37	Yes	No	0	6	6
57	L:L:?1	R:R:N93	19.864	6.52	Yes	No	1	0	6
58	R:R:N93	R:R:Y165	18.0797	4.65	No	Yes	1	6	7
59	R:R:P162	R:R:Y165	21.3557	4.17	Yes	Yes	0	5	7
60	L:L:?1	R:R:L166	12.8965	3.95	Yes	No	0	0	5
61	R:R:L166	R:R:Y251	10.895	8.21	No	No	0	5	4
62	L:L:?1	R:R:L244	25.3588	5.26	Yes	No	0	0	5
63	R:R:L244	R:R:V170	23.5461	4.47	No	No	0	5	4
64	R:R:V170	R:R:Y171	16.5597	5.05	No	Yes	4	4	5
65	R:R:H107	R:R:S185	47.281	2.79	Yes	No	0	9	9
66	R:R:A229	R:R:S185	45.0906	1.71	No	No	0	8	9
67	R:R:A229	R:R:L189	42.8814	1.58	No	No	0	8	7
68	R:R:L189	R:R:Q226	40.6533	7.99	No	No	0	7	7
69	R:R:H193	R:R:Q226	38.3875	1.24	No	No	0	7	7
70	R:R:H193	R:R:Q222	33.9218	2.47	No	No	0	7	7
71	R:R:L196	R:R:Q222	29.2863	13.31	Yes	No	0	5	7
72	R:R:L196	R:R:L218	19.8074	4.15	Yes	Yes	0	5	6
73	R:R:R194	R:R:T191	10.0736	1.29	No	No	0	5	6
74	R:R:L214	R:R:L218	12.5283	6.92	No	Yes	0	3	6
75	R:R:E203	R:R:L214	10.0453	6.63	No	No	0	3	3
76	R:R:C236	R:R:V276	31.8542	3.42	No	Yes	0	8	9
77	R:R:C236	R:R:S272	29.8622	1.72	No	No	0	8	9
78	R:R:G269	R:R:S272	23.7727	1.86	No	No	0	9	9
79	R:R:G269	R:R:T243	21.7051	5.46	No	No	0	9	5
80	R:R:L265	R:R:T243	19.6186	1.47	No	No	0	7	5
81	R:R:L246	R:R:L265	17.5132	2.77	No	No	0	5	7
82	R:R:L246	R:R:L262	15.389	5.54	No	No	0	5	2
83	R:R:L262	R:R:P255	11.0838	1.64	No	No	0	2	4
84	R:R:A275	R:R:I28	11.0933	1.62	No	No	0	6	8
85	R:R:L71	R:R:S270	17.1261	3	Yes	No	0	7	8
86	R:R:F96	R:R:Y240	16.1348	6.19	Yes	Yes	1	6	7
87	R:R:H107	R:R:M280	29.3995	3.94	Yes	Yes	6	9	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L71	3.95	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L74	6.58	1	Yes	No	0	5	0	1
L:L:?1	R:R:N93	6.52	1	Yes	No	0	6	0	1
L:L:?1	R:R:F96	12.73	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S157	8.56	1	Yes	No	0	5	0	1
L:L:?1	R:R:F161	3.47	1	Yes	No	0	5	0	1
L:L:?1	R:R:L166	3.95	1	Yes	No	0	5	0	1
L:L:?1	R:R:E169	8.81	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y240	4.46	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L244	5.26	1	Yes	No	0	5	0	1
L:L:?1	R:R:S247	7.13	1	Yes	No	0	5	0	1
L:L:?1	R:R:L266	3.95	1	Yes	No	0	7	0	1
R:R:F96	R:R:T64	5.19	1	Yes	Yes	6	8	1	2
R:R:L71	R:R:S270	3	0	Yes	No	7	8	1	2
R:R:L74	R:R:Q77	5.32	0	No	No	5	4	1	2
R:R:S157	R:R:Y89	10.17	0	No	Yes	5	5	1	2
R:R:I160	R:R:Y89	8.46	1	No	Yes	5	5	2	2
R:R:F161	R:R:Y89	4.13	1	No	Yes	5	5	1	2
R:R:N93	R:R:Y165	4.65	1	No	Yes	6	7	1	2
R:R:E169	R:R:N93	11.83	1	Yes	No	6	6	1	1
R:R:F96	R:R:Y240	6.19	1	Yes	Yes	6	7	1	1
R:R:F96	R:R:S270	3.96	1	Yes	No	6	8	1	2
R:R:E169	R:R:L97	6.63	1	Yes	No	6	7	1	2
R:R:F138	R:R:Y165	14.44	1	Yes	Yes	5	7	2	2
R:R:E169	R:R:F138	8.16	1	Yes	Yes	6	5	1	2
R:R:F161	R:R:I160	3.77	1	No	No	5	5	1	2
R:R:E169	R:R:Y165	3.37	1	Yes	Yes	6	7	1	2
R:R:L166	R:R:Y251	8.21	0	No	No	5	4	1	2
R:R:E169	R:R:L174	3.98	1	Yes	No	6	7	1	2
R:R:L244	R:R:V170	4.47	0	No	No	5	4	1	2
R:R:L174	R:R:L244	5.54	0	No	No	7	5	2	1
R:R:W237	R:R:Y240	6.75	0	Yes	Yes	8	7	2	1
R:R:A273	R:R:Y240	4	0	No	Yes	9	7	2	1
R:R:L71	R:R:P72	1.64	0	Yes	Yes	7	6	1	2
R:R:L71	R:R:P92	1.64	0	Yes	No	7	6	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7CFN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.83
Number of Linked Nodes	238
Number of Links	252
Number of Hubs	30
Number of Links mediated by Hubs	122
Number of Communities	7
Number of Nodes involved in Communities	37
Number of Links involved in Communities	45

Path Summary
Number Of Nodes in MetaPath	88
Number Of Links MetaPath	87
Number of Shortest Paths	31151
Length Of Smallest Path	3
Average Path Length	12.0042
Length of Longest Path	28
Minimum Path Strength	1.32
Average Path Strength	4.88422
Maximum Path Strength	16.13
Minimum Path Correlation	0.7
Average Path Correlation	0.931267
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.26316
Average % Of Corr. Nodes	57.8685
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.1761
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled bile acid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • multicellular organismal-level homeostasis • homeostatic process • energy homeostasis • bicellular tight junction assembly • regulation of bicellular tight junction assembly • regulation of cellular component organization • tight junction organization • apical junction assembly • regulation of cellular component biogenesis • cellular component organization • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • cholangiocyte proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cholangiocyte proliferation • regulation of cell population proliferation • positive regulation of cholangiocyte proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • cellular response to bile acid • response to bile acid • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FX0
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FX0
Name	(2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid
Synonyms
Identifier
Formula	C27 H46 O5
Molecular Weight	450.651
SMILES
PubChem	45483949
Formal Charge	0
Total Atoms	78
Total Chiral Atoms	13
Total Bonds	81
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDU6
Sequence	>7CFN_nogp_Chain_R L G L S L A L A S L I I T A N L L L A L G I A W D R R L R S P P A G C F F L S L L L A G L L T G L A L P T L P G L W N Q S R R G Y W S C L L V Y L A P N F S F L S L L A N L L L V H G E R Y M A V L R P L Q P P G S I R L A L L L T W A G P L L F A S L P A L G W N H W T P G A N C S S Q A I F P A P Y L Y L E V Y G L L L P A V G A A A F L S V R V L A T A H R Q L Q D I C R L E R A V C R D E P S A L A R A L T W R Q A R A Q A G A M L L F G L C W G P Y V A T L L L S V L A Y E Q R P P L G P G T L L S L L S L G S A S A A A V P V A M G L G D Q R Y T A P W Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7BW0	A	Steroid	Bile Acid	GPBA	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.9	2020-09-02	doi.org/10.1038/s41392-020-00262-z
	7BW0 (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	-	-		3.9	2020-09-02	doi.org/10.1038/s41392-020-00262-z
	7CFM	A	Steroid	Bile Acid	GPBA	Homo sapiens	P395	-	Gs/β1/γ2	3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7CFM (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	P395	-		3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7CFN	A	Steroid	Bile Acid	GPBA	Homo sapiens	INT-777	-	Gs/β1/γ2	3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7CFN (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	INT-777	-		3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7XTQ	A	Steroid	Bile Acid	GPBA	Homo sapiens	R399	-	Gs/β1/γ2	3.2	2022-07-06	doi.org/10.1073/pnas.2117054119
	7XTQ (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	R399	-		3.2	2022-07-06	doi.org/10.1073/pnas.2117054119
	9GYO	A	Steroid	Bile acid	GPBA	Homo sapiens	P395	-	chim(NtGi1-Gs)/β1/γ2	2.5	2024-10-09	doi.org/10.1038/s41598-025-16529-w
	9GYO (No Gprot)	A	Steroid	Bile acid	GPBA	Homo sapiens	P395	-		2.5	2024-10-09	doi.org/10.1038/s41598-025-16529-w

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

Data downloads are temporarily suspended for technical reasons. We apologize for the inconvenience.

Data downloads are temporarily suspended for technical reasons.
We apologize for the inconvenience.