Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1L:L:?1 6.280831210
2R:R:D42 4.4475427
3R:R:F53 7.596538
4R:R:T64 5.166508
5R:R:L68 2.35656
6R:R:L71 2.5575407
7R:R:P72 2.43506
8R:R:Y82 10.925404
9R:R:L86 4.81406
10R:R:Y89 6.3625415
11R:R:F96 7.0175416
12R:R:N102 7.805438
13R:R:H107 3.815469
14R:R:E109 2.9975409
15R:R:L115 5.99576
16R:R:I124 4.4475436
17R:R:W132 8.185439
18R:R:P135 3.4925408
19R:R:F138 8.0875415
20R:R:P162 3.6425405
21R:R:Y165 7.11167617
22R:R:E169 7.13616
23R:R:Y171 4.582545
24R:R:L196 5.895405
25R:R:L218 3.4275406
26R:R:W237 6.15833608
27R:R:Y240 5.35417
28R:R:V276 5.5625409
29R:R:M280 3.5125468
30R:R:Y287 9.194527
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1L:L:?1 R:R:L71 50.04723.95YesYes007
2R:R:L71 R:R:P72 58.47811.64YesYes076
3R:R:P72 R:R:S21 25.91583.56YesNo067
4R:R:L68 R:R:S21 20.28893YesNo067
5L:L:?1 R:R:F96 69.240912.73YesYes106
6R:R:F96 R:R:T64 1005.19YesYes068
7R:R:A274 R:R:T64 69.0713.36NoYes088
8R:R:A274 R:R:I28 66.75793.25NoNo088
9R:R:I28 R:R:N32 54.90942.83NoNo089
10R:R:L62 R:R:N32 11.09331.37NoNo069
11R:R:L58 R:R:N32 42.58874.12NoNo099
12R:R:F54 R:R:L58 37.52837.31NoNo089
13R:R:F54 R:R:Y287 32.39248.25NoYes087
14R:R:L45 R:R:Y287 16.53134.69NoYes287
15R:R:D42 R:R:L45 11.05558.14YesNo278
16R:R:L99 R:R:T64 75.22668.84NoYes098
17R:R:A60 R:R:L99 75.66093.15NoNo099
18R:R:A60 R:R:N102 73.81994.69NoYes098
19R:R:N102 R:R:S56 37.0947.45YesNo389
20R:R:L128 R:R:S56 35.50793NoNo379
21R:R:F53 R:R:L128 24.52796.09YesNo387
22R:R:E109 R:R:F53 40.35125.83YesYes098
23R:R:E109 R:R:P49 22.6023.14YesNo097
24R:R:P48 R:R:P49 18.11741.95NoNo037
25R:R:P48 R:R:S47 13.6141.78NoNo037
26R:R:N102 R:R:T131 28.42714.39YesNo086
27R:R:L105 R:R:T131 26.359511.79NoNo066
28R:R:F53 R:R:L105 24.291918.27YesNo086
29R:R:L99 R:R:P277 43.27793.28NoNo099
30L:L:?1 R:R:Y240 66.49364.46YesYes107
31R:R:W237 R:R:Y240 80.83466.75YesYes087
32R:R:V276 R:R:W237 26.11412.26YesYes098
33R:R:P277 R:R:V276 42.48493.53NoYes099
34R:R:F96 R:R:S270 18.3443.96YesNo068
35L:L:?1 R:R:L74 15.55896.58YesNo005
36R:R:L74 R:R:Q77 13.52915.32NoNo054
37R:R:G73 R:R:P72 20.41162.03NoYes026
38R:R:G73 R:R:W75 17.5511.41NoNo024
39R:R:N76 R:R:W75 14.67154.52NoNo034
40R:R:N76 R:R:S78 11.7732.98NoNo033
41L:L:?1 R:R:F161 29.72053.47YesNo105
42R:R:F161 R:R:I160 21.51623.77NoNo155
43R:R:I160 R:R:L86 19.78854.28NoYes056
44R:R:L86 R:R:Y82 11.17824.69YesYes064
45L:L:?1 R:R:E169 41.64468.81YesYes106
46R:R:E169 R:R:Y165 19.78853.37YesYes167
47R:R:E169 R:R:L97 15.64396.63YesNo067
48R:R:L97 R:R:P135 13.58573.28NoYes078
49R:R:L103 R:R:W237 52.18093.42NoYes098
50R:R:H107 R:R:L103 48.46115.14YesNo699
51R:R:M280 R:R:V276 33.05323.04YesYes089
52R:R:H107 R:R:R110 33.95963.39YesNo099
53R:R:R110 R:R:V188 31.6563.92NoNo099
54R:R:L115 R:R:V188 29.33352.98YesNo069
55R:R:L115 R:R:Y111 10.035910.55YesNo769
56R:R:L115 R:R:T191 12.53787.37YesNo066
57L:L:?1 R:R:N93 19.8646.52YesNo106
58R:R:N93 R:R:Y165 18.07974.65NoYes167
59R:R:P162 R:R:Y165 21.35574.17YesYes057
60L:L:?1 R:R:L166 12.89653.95YesNo005
61R:R:L166 R:R:Y251 10.8958.21NoNo054
62L:L:?1 R:R:L244 25.35885.26YesNo005
63R:R:L244 R:R:V170 23.54614.47NoNo054
64R:R:V170 R:R:Y171 16.55975.05NoYes445
65R:R:H107 R:R:S185 47.2812.79YesNo099
66R:R:A229 R:R:S185 45.09061.71NoNo089
67R:R:A229 R:R:L189 42.88141.58NoNo087
68R:R:L189 R:R:Q226 40.65337.99NoNo077
69R:R:H193 R:R:Q226 38.38751.24NoNo077
70R:R:H193 R:R:Q222 33.92182.47NoNo077
71R:R:L196 R:R:Q222 29.286313.31YesNo057
72R:R:L196 R:R:L218 19.80744.15YesYes056
73R:R:R194 R:R:T191 10.07361.29NoNo056
74R:R:L214 R:R:L218 12.52836.92NoYes036
75R:R:E203 R:R:L214 10.04536.63NoNo033
76R:R:C236 R:R:V276 31.85423.42NoYes089
77R:R:C236 R:R:S272 29.86221.72NoNo089
78R:R:G269 R:R:S272 23.77271.86NoNo099
79R:R:G269 R:R:T243 21.70515.46NoNo095
80R:R:L265 R:R:T243 19.61861.47NoNo075
81R:R:L246 R:R:L265 17.51322.77NoNo057
82R:R:L246 R:R:L262 15.3895.54NoNo052
83R:R:L262 R:R:P255 11.08381.64NoNo024
84R:R:A275 R:R:I28 11.09331.62NoNo068
85R:R:L71 R:R:S270 17.12613YesNo078
86R:R:F96 R:R:Y240 16.13486.19YesYes167
87R:R:H107 R:R:M280 29.39953.94YesYes698
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


2D representation of the interactions of this orthosteric/allosteric ligand.


Links and nodes colored according to ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Node1 Node2 LinkStrength Comm IsNode1Hub? IsNode2Hub? Node1Cons Node2Cons Node1Shell Node2Shell
L:L:?1 R:R:L71 3.95 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L74 6.58 1 Yes No 0 5 0 1
L:L:?1 R:R:N93 6.52 1 Yes No 0 6 0 1
L:L:?1 R:R:F96 12.73 1 Yes Yes 0 6 0 1
L:L:?1 R:R:S157 8.56 1 Yes No 0 5 0 1
L:L:?1 R:R:F161 3.47 1 Yes No 0 5 0 1
L:L:?1 R:R:L166 3.95 1 Yes No 0 5 0 1
L:L:?1 R:R:E169 8.81 1 Yes Yes 0 6 0 1
L:L:?1 R:R:Y240 4.46 1 Yes Yes 0 7 0 1
L:L:?1 R:R:L244 5.26 1 Yes No 0 5 0 1
L:L:?1 R:R:S247 7.13 1 Yes No 0 5 0 1
L:L:?1 R:R:L266 3.95 1 Yes No 0 7 0 1
R:R:F96 R:R:T64 5.19 1 Yes Yes 6 8 1 2
R:R:L71 R:R:S270 3 0 Yes No 7 8 1 2
R:R:L74 R:R:Q77 5.32 0 No No 5 4 1 2
R:R:S157 R:R:Y89 10.17 0 No Yes 5 5 1 2
R:R:I160 R:R:Y89 8.46 1 No Yes 5 5 2 2
R:R:F161 R:R:Y89 4.13 1 No Yes 5 5 1 2
R:R:N93 R:R:Y165 4.65 1 No Yes 6 7 1 2
R:R:E169 R:R:N93 11.83 1 Yes No 6 6 1 1
R:R:F96 R:R:Y240 6.19 1 Yes Yes 6 7 1 1
R:R:F96 R:R:S270 3.96 1 Yes No 6 8 1 2
R:R:E169 R:R:L97 6.63 1 Yes No 6 7 1 2
R:R:F138 R:R:Y165 14.44 1 Yes Yes 5 7 2 2
R:R:E169 R:R:F138 8.16 1 Yes Yes 6 5 1 2
R:R:F161 R:R:I160 3.77 1 No No 5 5 1 2
R:R:E169 R:R:Y165 3.37 1 Yes Yes 6 7 1 2
R:R:L166 R:R:Y251 8.21 0 No No 5 4 1 2
R:R:E169 R:R:L174 3.98 1 Yes No 6 7 1 2
R:R:L244 R:R:V170 4.47 0 No No 5 4 1 2
R:R:L174 R:R:L244 5.54 0 No No 7 5 2 1
R:R:W237 R:R:Y240 6.75 0 Yes Yes 8 7 2 1
R:R:A273 R:R:Y240 4 0 No Yes 9 7 2 1
R:R:L71 R:R:P72 1.64 0 Yes Yes 7 6 1 2
R:R:L71 R:R:P92 1.64 0 Yes No 7 6 1 2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB 7CFN_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 2.83
Number of Linked Nodes 238
Number of Links 252
Number of Hubs 30
Number of Links mediated by Hubs 122
Number of Communities 7
Number of Nodes involved in Communities 37
Number of Links involved in Communities 45
Path Summary
Number Of Nodes in MetaPath 88
Number Of Links MetaPath 87
Number of Shortest Paths 31151
Length Of Smallest Path 3
Average Path Length 12.0042
Length of Longest Path 28
Minimum Path Strength 1.32
Average Path Strength 4.88422
Maximum Path Strength 16.13
Minimum Path Correlation 0.7
Average Path Correlation 0.931268
Maximum Path Correlation 0.99
Minimum % Of Corr. Nodes 5.26316
Average % Of Corr. Nodes 57.8667
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 41.1761
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function• binding   • guanyl nucleotide binding   • GTP binding   • nucleotide binding   • guanyl ribonucleotide binding   • purine ribonucleotide binding   • purine ribonucleoside triphosphate binding   • nucleoside phosphate binding   • ion binding   • purine nucleotide binding   • anion binding   • heterocyclic compound binding   • carbohydrate derivative binding   • ribonucleotide binding   • small molecule binding   • D1 dopamine receptor binding   • protein binding   • signaling receptor binding   • G protein-coupled receptor binding   • dopamine receptor binding   • protein-containing complex binding   • G-protein beta/gamma-subunit complex binding   • pyrophosphatase activity   • GTPase activity   • G protein activity   • ribonucleoside triphosphate phosphatase activity   • molecular function regulator activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • enzyme regulator activity   • molecular function activator activity   • phosphorus-oxygen lyase activity   • cyclase regulator activity   • enzyme activator activity   • cyclase activator activity   • cyclase activity   • adenylate cyclase regulator activity   • lyase activity   • adenylate cyclase activator activity   • adenylate cyclase activity   • cation binding   • metal ion binding   • developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development
Gene OntologyBiological Process• developmental process   • multicellular organismal process   • epithelium development   • ectodermal placode morphogenesis   • epidermis development   • molting cycle process   • hair cycle   • animal organ development   • hair follicle placode formation   • tissue development   • ectodermal placode formation   • anatomical structure morphogenesis   • skin development   • skin epidermis development   • hair follicle development   • molting cycle   • anatomical structure development   • anatomical structure formation involved in morphogenesis   • ectodermal placode development   • hair cycle process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of smell   • cellular response to stimulus   • cellular response to nitrogen compound   • response to stimulus   • response to endogenous stimulus   • response to peptide hormone   • cellular response to peptide hormone stimulus   • response to oxygen-containing compound   • response to nitrogen compound   • response to glucagon   • cellular response to oxygen-containing compound   • cellular response to glucagon stimulus   • cellular response to endogenous stimulus   • cellular response to chemical stimulus   • response to hormone   • response to chemical   • cellular process   • cellular response to hormone stimulus   • multicellular organism development   • skeletal system development   • bone development   • system development   • regulation of body fluid levels   • wound healing   • homotypic cell-cell adhesion   • cell activation   • hemostasis   • biological regulation   • platelet aggregation   • blood coagulation   • cell adhesion   • cell-cell adhesion   • response to stress   • coagulation   • regulation of biological quality   • response to wounding   • platelet activation   • response to fluid shear stress   • vascular endothelial cell response to laminar fluid shear stress   • response to laminar fluid shear stress   • cellular response to stress   • cellular response to laminar fluid shear stress   • vascular endothelial cell response to fluid shear stress   • cellular response to fluid shear stress   • cognition   • developmental growth   • growth   • response to ketone   • response to prostaglandin   • response to lipid   • response to alcohol   • cellular response to prostaglandin stimulus   • cellular response to prostaglandin E stimulus   • cellular response to alcohol   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • regulation of biological process   • regulation of cellular process   • signaling   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cell communication   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • signal transduction   • homeostatic process   • positive regulation of biological process   • adaptive thermogenesis   • positive regulation of metabolic process   • multicellular organismal-level homeostasis   • regulation of cold-induced thermogenesis   • cold-induced thermogenesis   • temperature homeostasis   • positive regulation of cold-induced thermogenesis   • positive regulation of multicellular organismal process   • metabolic process   • regulation of multicellular organismal process   • regulation of metabolic process   • positive regulation of cellular process   • protein localization   • regulation of localization   • establishment of protein localization   • nitrogen compound transport   • localization   • cellular macromolecule localization   • regulation of peptide hormone secretion   • regulation of hormone levels   • establishment of protein localization to extracellular region   • protein secretion   • establishment of localization   • regulation of protein secretion   • regulation of secretion   • cellular localization   • regulation of hormone secretion   • regulation of protein localization   • regulation of peptide secretion   • transport   • hormone secretion   • protein localization to extracellular region   • peptide secretion   • regulation of secretion by cell   • secretion by cell   • amide transport   • signal release   • regulation of signaling   • regulation of transport   • secretion   • regulation of peptide transport   • regulation of establishment of protein localization   • export from cell   • cell-cell signaling   • regulation of protein transport   • peptide transport   • protein transport   • regulation of cellular localization   • regulation of insulin secretion   • peptide hormone secretion   • macromolecule localization   • hormone transport   • regulation of cell communication   • insulin secretion   • adenylate cyclase-activating adrenergic receptor signaling pathway   • adrenergic receptor signaling pathway   • establishment of localization in cell   • intracellular transport   • regulation of defense response   • regulation of response to external stimulus   • negative regulation of inflammatory response   • negative regulation of biological process   • inflammatory response to antigenic stimulus   • regulation of response to stress   • regulation of immune system process   • negative regulation of inflammatory response to antigenic stimulus   • defense response   • immune response   • negative regulation of response to stimulus   • negative regulation of immune response   • regulation of inflammatory response to antigenic stimulus   • response to external stimulus   • regulation of inflammatory response   • regulation of response to stimulus   • negative regulation of immune system process   • immune system process   • negative regulation of response to external stimulus   • negative regulation of defense response   • regulation of immune response   • inflammatory response   • positive regulation of adenylate cyclase activity   • positive regulation of molecular function   • regulation of molecular function   • positive regulation of cyclase activity   • activation of adenylate cyclase activity   • regulation of adenylate cyclase activity   • regulation of catalytic activity   • positive regulation of catalytic activity   • positive regulation of lyase activity   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • cellular response to monoamine stimulus   • renal system process   • chemical homeostasis   • multicellular organismal-level water homeostasis   • multicellular organismal-level chemical homeostasis   • renal water homeostasis   • cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex
Gene OntologyCellular Component• cellular anatomical structure   • membrane   • protein-containing complex   • extrinsic component of plasma membrane   • catalytic complex   • plasma membrane protein complex   • cytoplasmic side of membrane   • plasma membrane   • membrane protein complex   • heterotrimeric G-protein complex   • side of membrane   • cell periphery   • cytoplasmic side of plasma membrane   • GTPase complex   • extrinsic component of membrane   • extrinsic component of cytoplasmic side of plasma membrane   • extracellular exosome   • membrane-bounded organelle   • extracellular vesicle   • extracellular organelle   • extracellular region   • organelle   • extracellular space   • vesicle   • extracellular membrane-bounded organelle   • intracellular anatomical structure   • cytoplasm   • cytosol   • Golgi apparatus subcompartment   • Golgi apparatus   • organelle subcompartment   • trans-Golgi network membrane   • intracellular membrane-bounded organelle   • endomembrane system   • intracellular organelle   • trans-Golgi network   • organelle membrane   • protein binding   • binding   • enzyme binding   • GTPase binding   • protein-containing complex binding   • pyrophosphatase activity   • GTPase activity   • ribonucleoside triphosphate phosphatase activity   • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides   • hydrolase activity   • hydrolase activity, acting on acid anhydrides   • catalytic activity   • signaling receptor complex adaptor activity   • protein-macromolecule adaptor activity   • molecular adaptor activity   • signaling adaptor activity   • multicellular organismal process   • system process   • sensory perception of chemical stimulus   • sensory perception   • nervous system process   • sensory perception of taste   • developmental process   • sensory organ development   • eye development   • animal organ development   • retina development in camera-type eye   • visual system development   • multicellular organism development   • camera-type eye development   • anatomical structure development   • sensory system development   • system development   • cell population proliferation   • cellular process   • cellular response to stimulus   • regulation of biological process   • regulation of cellular process   • response to stimulus   • signaling   • biological regulation   • signal transduction   • cell communication   • response to ketone   • response to prostaglandin   • response to lipid   • response to endogenous stimulus   • response to alcohol   • cellular response to prostaglandin stimulus   • response to oxygen-containing compound   • cellular response to oxygen-containing compound   • cellular response to endogenous stimulus   • cellular response to prostaglandin E stimulus   • cellular response to chemical stimulus   • cellular response to alcohol   • response to hormone   • response to chemical   • cellular response to lipid   • response to prostaglandin E   • cellular response to ketone   • cellular response to hormone stimulus   • small GTPase-mediated signal transduction   • Ras protein signal transduction   • intracellular signal transduction   • intracellular signaling cassette   • phospholipase C-activating G protein-coupled receptor signaling pathway   • G protein-coupled receptor signaling pathway   • cellular response to nitrogen compound   • response to dopamine   • cellular response to dopamine   • response to monoamine   • response to catecholamine   • adenylate cyclase-activating dopamine receptor signaling pathway   • cellular response to catecholamine stimulus   • G protein-coupled dopamine receptor signaling pathway   • response to nitrogen compound   • adenylate cyclase-activating G protein-coupled receptor signaling pathway   • cellular response to monoamine stimulus   • adenylate cyclase-modulating G protein-coupled receptor signaling pathway   • synaptic signaling   • cellular response to acetylcholine   • cell-cell signaling   • acetylcholine receptor signaling pathway   • postsynaptic signal transduction   • G protein-coupled acetylcholine receptor signaling pathway   • response to acetylcholine   • non-motile cilium   • 9+0 non-motile cilium   • cilium   • neuron projection   • photoreceptor disc membrane   • photoreceptor outer segment   • plasma membrane bounded cell projection   • cell projection   • photoreceptor cell cilium   • vacuolar membrane   • lytic vacuole   • vacuole   • lytic vacuole membrane   • bounding membrane of organelle   • lysosomal membrane   • lysosome   • synapse   • cell junction   • G-protein beta-subunit binding   • fibroblast proliferation   • G protein-coupled bile acid receptor activity   • molecular transducer activity   • G protein-coupled receptor activity   • transmembrane signaling receptor activity   • signaling receptor activity   • cell surface receptor signaling pathway   • bile acid signaling pathway   • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway   • bicellular tight junction assembly   • regulation of bicellular tight junction assembly   • regulation of cellular component organization   • tight junction organization   • apical junction assembly   • regulation of cellular component biogenesis   • cellular component organization   • cellular component biogenesis   • regulation of cell junction assembly   • cell junction organization   • cellular component assembly   • cell junction assembly   • tight junction assembly   • cellular component organization or biogenesis   • cell-cell junction assembly   • cell-cell junction organization   • positive regulation of cell communication   • positive regulation of signal transduction   • positive regulation of biological process   • regulation of signal transduction   • positive regulation of response to stimulus   • positive regulation of ERK1 and ERK2 cascade   • regulation of intracellular signal transduction   • positive regulation of cellular process   • regulation of signaling   • positive regulation of MAPK cascade   • positive regulation of intracellular signal transduction   • regulation of MAPK cascade   • regulation of response to stimulus   • MAPK cascade   • regulation of cell communication   • ERK1 and ERK2 cascade   • regulation of ERK1 and ERK2 cascade   • positive regulation of signaling   • cholangiocyte proliferation   • positive regulation of cell population proliferation   • positive regulation of epithelial cell proliferation   • regulation of cholangiocyte proliferation   • regulation of cell population proliferation   • positive regulation of cholangiocyte proliferation   • regulation of epithelial cell proliferation   • epithelial cell proliferation   • cellular response to bile acid   • response to bile acid   • receptor complex
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
CodeFX0
PDB ResiduesL:L:?1
Environment DetailsOpen EMBL-EBI Page
CodeFX0
Name(2S,4R)-4-[(3R,5S,6R,7R,8R,9S,10S,12S,13R,14S,17R)-6-ethyl-10,13-dimethyl-3,7,12-tris(oxidanyl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-methyl-pentanoic acid
Synonyms
Identifier
FormulaC27 H46 O5
Molecular Weight450.651
SMILES
PubChem45483949
Formal Charge0
Total Atoms78
Total Chiral Atoms13
Total Bonds81
Total Aromatic Bonds0

PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDU6
Sequence
>7CFN_nogp_Chain_R
LGLSLALAS LIITANLLL ALGIAWDRR LRSPPAGCF FLSLLLAGL 
LTGLALPTL PGLWNQSRR GYWSCLLVY LAPNFSFLS LLANLLLVH 
GERYMAVLR PLQPPGSIR LALLLTWAG PLLFASLPA LGWNHWTPG 
ANCSSQAIF PAPYLYLEV YGLLLPAVG AAAFLSVRV LATAHRQLQ 
DICRLERAV CRDEPSALA RALTWRQAR AQAGAMLLF GLCWGPYVA 
TLLLSVLAY EQRPPLGPG TLLSLLSLG SASAAAVPV AMGLGDQRY 
TAPW


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9GYOASteroidBile acidGPBAHomo sapiensP395-chim(NtGi1-Gs)/β1/γ22.52024-10-09To be published
9GYO (No Gprot) ASteroidBile acidGPBAHomo sapiensP395-2.52024-10-09To be published
7XTQASteroidBile AcidGPBAHomo sapiensR399-Gs/β1/γ23.22022-07-0610.1073/pnas.2117054119
7XTQ (No Gprot) ASteroidBile AcidGPBAHomo sapiensR399-3.22022-07-0610.1073/pnas.2117054119
7CFNASteroidBile AcidGPBAHomo sapiensINT-777-Gs/β1/γ232020-09-0910.1038/s41586-020-2569-1
7CFN (No Gprot) ASteroidBile AcidGPBAHomo sapiensINT-777-32020-09-0910.1038/s41586-020-2569-1
7CFMASteroidBile AcidGPBAHomo sapiensP395-Gs/β1/γ232020-09-0910.1038/s41586-020-2569-1
7CFM (No Gprot) ASteroidBile AcidGPBAHomo sapiensP395-32020-09-0910.1038/s41586-020-2569-1
7BW0ASteroidBile AcidGPBAHomo sapiens--chim(NtGi1-Gs)/β1/γ23.92020-09-0210.1038/s41392-020-00262-z
7BW0 (No Gprot) ASteroidBile AcidGPBAHomo sapiens--3.92020-09-0210.1038/s41392-020-00262-z




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Download 7CFN_nogp.zip



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