psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:L71	4.59	Yes	Yes	1	0	7
2	L:L:?1	R:R:L74	12.63	Yes	No	1	0	5
3	L:L:?1	R:R:W75	13.23	Yes	Yes	1	0	4
4	L:L:?1	R:R:N93	4.56	Yes	Yes	1	0	6
5	L:L:?1	R:R:F96	13.13	Yes	Yes	1	0	6
6	L:L:?1	R:R:F161	6.06	Yes	Yes	1	0	5
7	L:L:?1	R:R:L166	5.74	Yes	Yes	1	0	5
8	L:L:?1	R:R:E169	8.79	Yes	Yes	1	0	6
9	L:L:?1	R:R:Y240	4.86	Yes	Yes	1	0	7
10	L:L:?1	R:R:T243	2.45	Yes	No	1	0	5
11	L:L:?1	R:R:S247	12.45	Yes	No	1	0	5
12	L:L:?1	R:R:Y251	3.89	Yes	Yes	1	0	4
13	L:L:?1	R:R:L266	3.44	Yes	No	1	0	7
14	L:L:?1	R:R:S270	4.98	Yes	No	1	0	8
15	R:R:L68	R:R:S21	3	Yes	No	3	6	7
16	R:R:P69	R:R:S21	3.56	No	No	3	9	7
17	R:R:S21	R:R:S267	3.26	No	No	0	7	6
18	R:R:A25	R:R:L68	4.73	No	Yes	3	7	6
19	R:R:A25	R:R:P69	3.74	No	No	3	7	9
20	R:R:G65	R:R:I28	3.53	No	No	0	9	8
21	R:R:G65	R:R:I29	3.53	No	No	0	9	6
22	R:R:N32	R:R:V278	4.43	No	Yes	0	9	6
23	R:R:L33	R:R:L37	2.77	No	No	0	5	4
24	R:R:L33	R:R:L62	2.77	No	No	0	5	6
25	R:R:L34	R:R:W291	6.83	No	Yes	0	7	6
26	R:R:L35	R:R:L58	2.77	No	No	0	9	9
27	R:R:L35	R:R:V278	2.98	No	Yes	0	9	6
28	R:R:A36	R:R:L58	3.15	No	No	0	8	9
29	R:R:G38	R:R:W291	2.81	No	Yes	0	8	6
30	R:R:I39	R:R:R46	5.01	No	No	0	8	8
31	R:R:I39	R:R:L55	5.71	No	No	0	8	7
32	R:R:I39	R:R:Y287	6.04	No	No	0	8	7
33	R:R:D42	R:R:L45	12.21	No	No	4	7	8
34	R:R:D42	R:R:R46	4.76	No	No	4	7	8
35	R:R:L45	R:R:R46	3.64	No	No	4	8	8
36	R:R:P48	R:R:S47	3.56	No	No	0	3	7
37	R:R:F53	R:R:P49	4.33	Yes	No	5	8	7
38	R:R:I124	R:R:P49	8.47	No	No	5	6	7
39	R:R:A50	R:R:E109	4.53	No	No	0	8	9
40	R:R:C52	R:R:I124	3.27	No	No	0	3	6
41	R:R:F53	R:R:L105	19.49	Yes	No	0	8	6
42	R:R:E109	R:R:F53	8.16	No	Yes	0	9	8
43	R:R:F53	R:R:I124	2.51	Yes	No	5	8	6
44	R:R:A127	R:R:F53	2.77	No	Yes	0	5	8
45	R:R:F53	R:R:L128	4.87	Yes	No	0	8	7
46	R:R:F54	R:R:L58	9.74	No	No	0	8	9
47	R:R:F54	R:R:G281	3.01	No	No	0	8	7
48	R:R:F54	R:R:Y287	16.5	No	No	0	8	7
49	R:R:N102	R:R:S56	8.94	Yes	No	2	8	9
50	R:R:L128	R:R:S56	3	No	No	0	7	9
51	R:R:S56	R:R:W132	6.18	No	Yes	2	9	9
52	R:R:L57	R:R:N102	2.75	Yes	Yes	0	9	8
53	R:R:L103	R:R:L57	2.77	Yes	Yes	0	9	9
54	R:R:L57	R:R:P277	8.21	Yes	No	0	9	9
55	R:R:A60	R:R:N102	4.69	No	Yes	2	9	8
56	R:R:A60	R:R:W132	2.59	No	Yes	2	9	9
57	R:R:G61	R:R:T64	3.64	No	Yes	0	9	8
58	R:R:S95	R:R:T64	6.4	No	Yes	1	5	8
59	R:R:F96	R:R:T64	3.89	Yes	Yes	1	6	8
60	R:R:L99	R:R:T64	2.95	No	Yes	0	9	8
61	R:R:A274	R:R:T64	3.36	No	Yes	0	8	8
62	R:R:A67	R:R:P92	3.74	No	No	0	7	6
63	R:R:A67	R:R:S95	3.42	No	No	0	7	5
64	R:R:L68	R:R:P69	3.28	Yes	No	3	6	9
65	R:R:F96	R:R:L71	2.44	Yes	Yes	1	6	7
66	R:R:L71	R:R:S270	3	Yes	No	1	7	8
67	R:R:L74	R:R:W75	4.56	No	Yes	1	5	4
68	R:R:L74	R:R:Y89	4.69	No	Yes	1	5	5
69	R:R:S157	R:R:W75	2.47	Yes	Yes	1	5	4
70	R:R:S247	R:R:W75	2.47	No	Yes	1	5	4
71	R:R:A250	R:R:W75	2.59	No	Yes	0	4	4
72	R:R:L266	R:R:W75	3.42	No	Yes	1	7	4
73	R:R:Q77	R:R:S156	2.89	No	No	0	4	4
74	R:R:N154	R:R:R79	8.44	No	No	0	3	3
75	R:R:R80	R:R:S84	3.95	No	No	0	4	3
76	R:R:C85	R:R:R80	8.36	No	No	0	9	4
77	R:R:R80	R:R:V88	2.62	No	No	0	4	5
78	R:R:W83	R:R:Y82	8.68	No	Yes	0	1	4
79	R:R:L86	R:R:Y82	3.52	No	Yes	0	6	4
80	R:R:N147	R:R:Y82	5.81	No	Yes	0	8	4
81	R:R:W149	R:R:Y82	12.54	No	Yes	0	3	4
82	R:R:C85	R:R:Y89	2.69	No	Yes	1	9	5
83	R:R:C155	R:R:C85	7.28	No	No	1	9	9
84	R:R:L86	R:R:L90	8.3	No	No	0	6	5
85	R:R:A143	R:R:L86	4.73	No	No	0	6	6
86	R:R:C155	R:R:Y89	2.69	No	Yes	1	9	5
87	R:R:S157	R:R:Y89	3.82	Yes	Yes	1	5	5
88	R:R:F161	R:R:Y89	5.16	Yes	Yes	1	5	5
89	R:R:L90	R:R:P142	4.93	No	No	0	5	8
90	R:R:F161	R:R:L90	6.09	Yes	No	0	5	5
91	R:R:L97	R:R:N93	4.12	No	Yes	0	7	6
92	R:R:F161	R:R:N93	2.42	Yes	Yes	1	5	6
93	R:R:N93	R:R:Y165	5.81	Yes	Yes	1	6	7
94	R:R:E169	R:R:N93	10.52	Yes	Yes	1	6	6
95	R:R:F94	R:R:S98	2.64	No	No	2	5	7
96	R:R:F94	R:R:W132	5.01	No	Yes	2	5	9
97	R:R:F96	R:R:S95	6.61	Yes	No	1	6	5
98	R:R:F96	R:R:Y240	9.28	Yes	Yes	1	6	7
99	R:R:F96	R:R:S270	6.61	Yes	No	1	6	8
100	R:R:L173	R:R:L97	2.77	No	No	0	4	7
101	R:R:S98	R:R:W132	6.18	No	Yes	2	7	9
102	R:R:L100	R:R:L99	2.77	Yes	No	0	8	9
103	R:R:L100	R:R:L174	6.92	Yes	No	0	8	7
104	R:R:A177	R:R:L100	4.73	No	Yes	0	8	8
105	R:R:L100	R:R:W237	4.56	Yes	Yes	1	8	8
106	R:R:L100	R:R:Y240	2.34	Yes	Yes	1	8	7
107	R:R:N102	R:R:T131	4.39	Yes	Yes	2	8	6
108	R:R:N102	R:R:W132	14.69	Yes	Yes	2	8	9
109	R:R:H107	R:R:L103	7.71	Yes	Yes	0	9	9
110	R:R:L103	R:R:W237	4.56	Yes	Yes	0	9	8
111	R:R:L103	R:R:M280	2.83	Yes	No	0	9	8
112	R:R:L105	R:R:T131	11.79	No	Yes	0	6	6
113	R:R:H107	R:R:R110	3.39	Yes	Yes	6	9	9
114	R:R:H107	R:R:L184	2.57	Yes	Yes	0	9	7
115	R:R:H107	R:R:S185	5.58	Yes	No	6	9	9
116	R:R:R110	R:R:S185	2.64	Yes	No	6	9	9
117	R:R:R110	R:R:V188	6.54	Yes	No	0	9	9
118	R:R:M112	R:R:Y111	2.39	No	Yes	0	5	9
119	R:R:L115	R:R:Y111	9.38	No	Yes	0	6	9
120	R:R:L184	R:R:Y111	8.21	Yes	Yes	0	7	9
121	R:R:R187	R:R:Y111	6.17	No	Yes	0	6	9
122	R:R:V188	R:R:Y111	2.52	No	Yes	0	9	9
123	R:R:L115	R:R:V114	2.98	No	No	7	6	8
124	R:R:V114	R:R:V188	3.21	No	No	0	8	9
125	R:R:T191	R:R:V114	3.17	No	No	7	6	8
126	R:R:L115	R:R:T191	7.37	No	No	7	6	6
127	R:R:Q119	R:R:R116	22.2	No	No	0	5	5
128	R:R:L126	R:R:S123	7.51	No	No	0	3	6
129	R:R:T131	R:R:W132	2.43	Yes	Yes	2	6	9
130	R:R:G134	R:R:P135	4.06	No	No	0	2	8
131	R:R:G134	R:R:L137	5.13	No	No	0	2	4
132	R:R:F138	R:R:Y165	7.22	Yes	Yes	1	5	7
133	R:R:F138	R:R:L168	3.65	Yes	No	0	5	6
134	R:R:E169	R:R:F138	3.5	Yes	Yes	1	6	5
135	R:R:F138	R:R:L173	7.31	Yes	No	0	5	4
136	R:R:L144	R:R:S140	4.5	No	No	0	4	5
137	R:R:L141	R:R:P142	3.28	No	No	0	5	8
138	R:R:L141	R:R:L144	2.77	No	No	0	5	4
139	R:R:L141	R:R:W146	3.42	No	No	0	5	6
140	R:R:P142	R:R:Y165	11.13	No	Yes	0	8	7
141	R:R:P162	R:R:W146	6.76	No	No	1	5	6
142	R:R:W146	R:R:Y165	3.86	No	Yes	1	6	7
143	R:R:A159	R:R:W149	2.59	No	No	0	2	3
144	R:R:I160	R:R:W149	3.52	No	No	0	5	3
145	R:R:P151	R:R:T150	3.5	No	No	0	2	3
146	R:R:C155	R:R:I160	3.27	No	No	0	9	5
147	R:R:S156	R:R:S157	3.26	No	Yes	1	4	5
148	R:R:Q158	R:R:S156	5.78	No	No	1	3	4
149	R:R:Q158	R:R:S157	8.66	No	Yes	1	3	5
150	R:R:S157	R:R:Y251	2.54	Yes	Yes	1	5	4
151	R:R:Q158	R:R:Y251	6.76	No	Yes	1	3	4
152	R:R:F161	R:R:I160	5.02	Yes	No	0	5	5
153	R:R:F161	R:R:Y165	7.22	Yes	Yes	1	5	7
154	R:R:P162	R:R:Y165	9.74	No	Yes	1	5	7
155	R:R:A163	R:R:Y251	2.67	No	Yes	0	4	4
156	R:R:E169	R:R:Y165	12.35	Yes	Yes	1	6	7
157	R:R:E169	R:R:L166	6.63	Yes	Yes	1	6	5
158	R:R:L166	R:R:V170	2.98	Yes	Yes	0	5	4
159	R:R:L166	R:R:Y251	8.21	Yes	Yes	1	5	4
160	R:R:V248	R:R:Y167	2.52	No	No	0	6	6
161	R:R:E252	R:R:Y167	3.37	Yes	No	0	1	6
162	R:R:V170	R:R:Y171	6.31	Yes	No	0	4	5
163	R:R:L244	R:R:V170	4.47	No	Yes	0	5	4
164	R:R:V170	R:R:V248	4.81	Yes	No	0	4	6
165	R:R:L175	R:R:Y171	2.34	No	No	0	6	5
166	R:R:L245	R:R:Y171	2.34	No	No	0	5	5
167	R:R:G172	R:R:P176	4.06	No	No	0	4	3
168	R:R:L174	R:R:L244	5.54	No	No	0	7	5
169	R:R:L175	R:R:V241	4.47	No	No	0	6	6
170	R:R:V178	R:R:W237	6.13	No	Yes	0	7	8
171	R:R:A181	R:R:F233	2.77	No	Yes	0	8	9
172	R:R:A182	R:R:F233	4.16	No	Yes	0	5	9
173	R:R:F183	R:R:L184	2.44	No	Yes	0	3	7
174	R:R:F183	R:R:R187	11.76	No	No	0	3	6
175	R:R:F233	R:R:S185	2.64	Yes	No	0	9	9
176	R:R:L189	R:R:Q226	6.65	Yes	No	0	7	7
177	R:R:A192	R:R:Q222	4.55	No	No	0	9	7
178	R:R:H193	R:R:Q226	2.47	No	No	0	7	7
179	R:R:C200	R:R:L196	3.17	No	Yes	0	4	5
180	R:R:L196	R:R:L218	2.77	Yes	No	0	5	6
181	R:R:L196	R:R:T219	2.95	Yes	No	0	5	7
182	R:R:L196	R:R:Q222	2.66	Yes	No	0	5	7
183	R:R:Q197	R:R:R201	2.34	No	No	0	6	5
184	R:R:D198	R:R:R201	3.57	No	No	0	6	5
185	R:R:E203	R:R:I199	2.73	No	No	0	3	7
186	R:R:C200	R:R:R204	2.79	No	No	0	4	4
187	R:R:E203	R:R:S212	5.75	No	No	0	3	3
188	R:R:D209	R:R:R208	3.57	No	No	0	1	1
189	R:R:E210	R:R:P211	3.14	No	No	0	2	3
190	R:R:P211	R:R:R216	5.76	No	No	0	3	3
191	R:R:L214	R:R:L218	5.54	No	No	0	3	6
192	R:R:R221	R:R:R224	4.26	No	No	0	8	7
193	R:R:L231	R:R:L235	2.77	No	No	0	5	4
194	R:R:L232	R:R:V276	4.47	No	Yes	0	6	9
195	R:R:F233	R:R:W237	5.01	Yes	Yes	0	9	8
196	R:R:C236	R:R:S272	3.44	No	No	0	8	9
197	R:R:C236	R:R:V276	6.83	No	Yes	0	8	9
198	R:R:W237	R:R:Y240	6.75	Yes	Yes	1	8	7
199	R:R:V276	R:R:W237	8.58	Yes	Yes	0	9	8
200	R:R:G238	R:R:P239	4.06	No	No	0	6	9
201	R:R:L244	R:R:Y240	4.69	No	Yes	0	5	7
202	R:R:A273	R:R:Y240	5.34	No	Yes	0	9	7
203	R:R:L245	R:R:V241	2.98	No	No	0	5	6
204	R:R:L266	R:R:T243	4.42	No	No	1	7	5
205	R:R:G269	R:R:T243	5.46	No	No	0	9	5
206	R:R:L246	R:R:P256	3.28	No	No	0	5	4
207	R:R:E252	R:R:L249	2.65	Yes	No	8	1	4
208	R:R:L249	R:R:R254	3.64	No	No	8	4	1
209	R:R:E252	R:R:R254	6.98	Yes	No	8	1	1
210	R:R:P255	R:R:R254	2.88	No	No	0	4	1
211	R:R:G258	R:R:L257	3.42	No	No	0	4	1
212	R:R:L257	R:R:T261	8.84	No	No	0	1	5
213	R:R:G258	R:R:P259	4.06	No	No	0	4	5
214	R:R:G260	R:R:L263	3.42	No	No	0	1	5
215	R:R:P277	R:R:V276	5.3	No	Yes	0	9	9
216	R:R:D284	R:R:R286	7.15	No	No	0	8	5
217	R:R:D284	R:R:Y287	13.79	No	No	0	8	7
218	R:R:P290	R:R:W291	2.7	No	Yes	0	6	6
219	R:R:L59	R:R:W132	2.28	No	Yes	0	7	9
220	R:R:L63	R:R:W132	2.28	No	Yes	0	6	9
221	R:R:P48	R:R:P49	1.95	No	No	0	3	7
222	R:R:A50	R:R:G51	1.95	No	No	0	8	8
223	R:R:P120	R:R:P121	1.95	No	No	0	8	3
224	R:R:A133	R:R:G134	1.95	No	No	0	3	2
225	R:R:P162	R:R:P164	1.95	No	No	0	5	4
226	R:R:A227	R:R:G228	1.95	No	No	0	7	6
227	R:R:P255	R:R:P256	1.95	No	No	0	4	4
228	R:R:A91	R:R:P92	1.87	No	No	0	3	6
229	R:R:A101	R:R:P135	1.87	No	No	0	5	8
230	R:R:A289	R:R:P290	1.87	No	No	0	4	6
231	R:R:G81	R:R:S84	1.86	No	No	0	5	3
232	R:R:G179	R:R:V178	1.84	No	No	0	4	7
233	R:R:A215	R:R:C200	1.81	No	No	0	4	4
234	R:R:P239	R:R:S272	1.78	No	No	0	9	9
235	R:R:C207	R:R:S212	1.72	No	No	0	4	3
236	R:R:G38	R:R:L37	1.71	No	No	0	8	4
237	R:R:G65	R:R:L68	1.71	No	Yes	0	9	6
238	R:R:G108	R:R:L184	1.71	No	Yes	0	6	7
239	R:R:A215	R:R:S212	1.71	No	No	0	4	3
240	R:R:G269	R:R:L268	1.71	No	No	0	9	8
241	R:R:G283	R:R:L282	1.71	No	No	0	4	6
242	R:R:A31	R:R:V278	1.7	No	Yes	0	8	6
243	R:R:G61	R:R:N32	1.7	No	No	0	9	9
244	R:R:A275	R:R:V278	1.7	No	Yes	0	6	6
245	R:R:A101	R:R:T131	1.68	No	Yes	0	5	6
246	R:R:L71	R:R:P72	1.64	Yes	No	0	7	6
247	R:R:L118	R:R:P117	1.64	No	No	0	8	9
248	R:R:L175	R:R:P176	1.64	No	No	0	6	3
249	R:R:L262	R:R:P256	1.64	No	No	0	2	4
250	R:R:A274	R:R:I28	1.62	No	No	0	8	8
251	R:R:A275	R:R:I28	1.62	No	No	0	6	8
252	R:R:S26	R:R:T30	1.6	No	No	0	4	2
253	R:R:T70	R:R:V88	1.59	No	No	0	4	5
254	R:R:A271	R:R:L24	1.58	No	No	0	6	7
255	R:R:A271	R:R:L68	1.58	No	Yes	0	6	6
256	R:R:A180	R:R:L104	1.58	No	No	0	5	7
257	R:R:P120	R:R:Q119	1.58	No	No	0	8	5
258	R:R:A225	R:R:L189	1.58	No	Yes	0	8	7
259	R:R:A139	R:R:N93	1.56	No	Yes	0	7	6
260	R:R:C207	R:R:E210	1.52	No	No	0	4	2
261	R:R:A289	R:R:Q285	1.52	No	No	0	4	6
262	R:R:F233	R:R:G234	1.51	Yes	No	0	9	5
263	R:R:L57	R:R:V106	1.49	Yes	No	0	9	9
264	R:R:L282	R:R:V278	1.49	No	Yes	0	6	6
265	R:R:L27	R:R:T30	1.47	No	No	0	3	2
266	R:R:P117	R:R:R116	1.44	No	No	0	9	5
267	R:R:I29	R:R:L62	1.43	No	No	0	6	6
268	R:R:I29	R:R:L66	1.43	No	No	0	6	5
269	R:R:E203	R:R:V206	1.43	No	No	0	3	4
270	R:R:L20	R:R:L24	1.38	No	No	0	4	7
271	R:R:L126	R:R:L130	1.38	No	No	0	3	2
272	R:R:L246	R:R:L265	1.38	No	No	0	5	7
273	R:R:L265	R:R:L268	1.38	No	No	0	7	8
274	R:R:L189	R:R:Q222	1.33	Yes	No	0	7	7
275	R:R:E252	R:R:Q253	1.27	Yes	No	0	1	2
276	R:R:M112	R:R:R116	1.24	No	No	0	5	5
277	R:R:F94	R:R:L136	1.22	No	No	0	5	5
278	R:R:L189	R:R:R110	1.21	Yes	Yes	0	7	9
279	R:R:L218	R:R:R221	1.21	No	No	0	6	8
280	R:R:T288	R:R:W291	1.21	No	Yes	0	8	6
281	R:R:D42	R:R:R44	1.19	No	No	0	7	6
282	R:R:Q197	R:R:R194	1.17	No	No	0	6	5
283	R:R:L263	R:R:W75	1.14	No	Yes	0	5	4
284	R:R:R201	R:R:R204	1.07	No	No	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	7.2	14	1	0
2	R:R:F53	7.02167	6	5	8
3	R:R:L57	3.805	4	0	9
4	R:R:T64	4.048	5	1	8
5	R:R:L68	2.86	5	3	6
6	R:R:L71	2.9175	4	1	7
7	R:R:W75	4.26857	7	1	4
8	R:R:Y82	7.6375	4	0	4
9	R:R:Y89	3.81	5	1	5
10	R:R:N93	4.83167	6	1	6
11	R:R:F96	6.99333	6	1	6
12	R:R:L100	4.264	5	1	8
13	R:R:N102	7.092	5	2	8
14	R:R:L103	4.4675	4	0	9
15	R:R:H107	4.8125	4	6	9
16	R:R:R110	3.445	4	6	9
17	R:R:Y111	5.734	5	0	9
18	R:R:T131	5.0725	4	2	6
19	R:R:W132	5.205	8	2	9
20	R:R:F138	5.42	4	1	5
21	R:R:S157	4.15	5	1	5
22	R:R:F161	5.32833	6	1	5
23	R:R:Y165	8.19	7	1	7
24	R:R:L166	5.89	4	1	5
25	R:R:E169	8.358	5	1	6
26	R:R:V170	4.6425	4	0	4
27	R:R:L184	3.7325	4	0	7
28	R:R:L189	2.6925	4	0	7
29	R:R:L196	2.8875	4	0	5
30	R:R:F233	3.218	5	0	9
31	R:R:W237	5.93167	6	1	8
32	R:R:Y240	5.54333	6	1	7
33	R:R:Y251	4.814	5	1	4
34	R:R:E252	3.5675	4	8	1
35	R:R:V276	6.295	4	0	9
36	R:R:V278	2.46	5	0	6
37	R:R:W291	3.3875	4	0	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:F96	25.4887	13.13	Yes	Yes	1	0	6
2	R:R:F96	R:R:T64	52.9663	3.89	Yes	Yes	1	6	8
3	R:R:A274	R:R:T64	42.6675	3.36	No	Yes	0	8	8
4	R:R:A274	R:R:I28	41.0542	1.62	No	No	0	8	8
5	R:R:G65	R:R:I28	39.2872	3.53	No	No	0	9	8
6	R:R:G65	R:R:L68	15.4631	1.71	No	Yes	0	9	6
7	R:R:G65	R:R:I29	22.8468	3.53	No	No	0	9	6
8	R:R:G61	R:R:T64	35.6936	3.64	No	Yes	0	9	8
9	R:R:G61	R:R:N32	33.901	1.7	No	No	0	9	9
10	R:R:N32	R:R:V278	32.2877	4.43	No	Yes	0	9	6
11	R:R:I29	R:R:L62	19.0994	1.43	No	No	0	6	6
12	R:R:L33	R:R:L62	17.213	2.77	No	No	0	5	6
13	R:R:L33	R:R:L37	15.318	2.77	No	No	0	5	4
14	R:R:G38	R:R:L37	13.4144	1.71	No	No	0	8	4
15	R:R:G38	R:R:W291	11.4981	2.81	No	Yes	0	8	6
16	R:R:L35	R:R:V278	26.7051	2.98	No	Yes	0	9	6
17	R:R:L35	R:R:L58	24.8528	2.77	No	No	0	9	9
18	R:R:F54	R:R:L58	21.1225	9.74	No	No	0	8	9
19	R:R:F54	R:R:Y287	17.3581	16.5	No	No	0	8	7
20	R:R:I39	R:R:Y287	11.6475	6.04	No	No	0	8	7
21	L:L:?1	R:R:Y240	62.9364	4.86	Yes	Yes	1	0	7
22	R:R:W237	R:R:Y240	100	6.75	Yes	Yes	1	8	7
23	R:R:L103	R:R:W237	87.2002	4.56	Yes	Yes	0	9	8
24	R:R:L103	R:R:L57	47.149	2.77	Yes	Yes	0	9	9
25	R:R:L57	R:R:N102	45.9496	2.75	Yes	Yes	0	9	8
26	R:R:N102	R:R:S56	15.0576	8.94	Yes	No	2	8	9
27	R:R:L128	R:R:S56	14.1827	3	No	No	0	7	9
28	R:R:F53	R:R:L128	12.9193	4.87	Yes	No	0	8	7
29	R:R:N102	R:R:T131	21.3103	4.39	Yes	Yes	2	8	6
30	R:R:L105	R:R:T131	14.3961	11.79	No	Yes	0	6	6
31	R:R:F53	R:R:L105	13.1327	19.49	Yes	No	0	8	6
32	R:R:L99	R:R:T64	26.9825	2.95	No	Yes	0	9	8
33	R:R:L100	R:R:L99	27.4861	2.77	Yes	No	0	8	9
34	R:R:C85	R:R:Y89	12.9962	2.69	No	Yes	1	9	5
35	R:R:C85	R:R:R80	10.9816	8.36	No	No	0	9	4
36	L:L:?1	R:R:F161	34.8997	6.06	Yes	Yes	1	0	5
37	R:R:F161	R:R:L90	10.4225	6.09	Yes	No	0	5	5
38	L:L:?1	R:R:N93	13.8882	4.56	Yes	Yes	1	0	6
39	R:R:N93	R:R:Y165	10.1152	5.81	Yes	Yes	1	6	7
40	R:R:P142	R:R:Y165	11.9761	11.13	No	Yes	0	8	7
41	R:R:F161	R:R:Y165	11.4341	7.22	Yes	Yes	1	5	7
42	L:L:?1	R:R:E169	13.7729	8.79	Yes	Yes	1	0	6
43	R:R:E169	R:R:Y165	11.195	12.35	Yes	Yes	1	6	7
44	R:R:L244	R:R:Y240	13.8284	4.69	No	Yes	0	5	7
45	R:R:H107	R:R:L103	55.1558	7.71	Yes	Yes	0	9	9
46	R:R:H107	R:R:R110	36.6965	3.39	Yes	Yes	6	9	9
47	R:R:F233	R:R:W237	36.3636	5.01	Yes	Yes	0	9	8
48	R:R:F233	R:R:S185	32.6419	2.64	Yes	No	0	9	9
49	R:R:R110	R:R:S185	31.545	2.64	Yes	No	6	9	9
50	R:R:H107	R:R:L184	18.3099	2.57	Yes	Yes	0	9	7
51	R:R:L184	R:R:Y111	13.312	8.21	Yes	Yes	0	7	9
52	R:R:L141	R:R:P142	11.9334	3.28	No	No	0	5	8
53	R:R:L141	R:R:L144	13.8498	2.77	No	No	0	5	4
54	R:R:W146	R:R:Y165	11.8267	3.86	No	Yes	1	6	7
55	R:R:V170	R:R:V248	10.064	4.81	Yes	No	0	4	6
56	R:R:V170	R:R:Y171	10.1238	6.31	Yes	No	0	4	5
57	R:R:L189	R:R:R110	60.9006	1.21	Yes	Yes	0	7	9
58	R:R:L189	R:R:Q222	52.3944	1.33	Yes	No	0	7	7
59	R:R:L196	R:R:Q222	48.1306	2.66	Yes	No	0	5	7
60	R:R:C200	R:R:L196	34.8528	3.17	No	Yes	0	4	5
61	R:R:C200	R:R:R204	11.8609	2.79	No	No	0	4	4
62	R:R:A215	R:R:C200	21.0969	1.81	No	No	0	4	4
63	R:R:A215	R:R:S212	18.8732	1.71	No	No	0	4	3
64	R:R:F96	R:R:Y240	34.2467	9.28	Yes	Yes	1	6	7
65	R:R:L244	R:R:V170	12.6376	4.47	No	Yes	0	5	4
66	R:R:L100	R:R:W237	27.9812	4.56	Yes	Yes	1	8	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:L71	4.59	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:L74	12.63	1	Yes	No	0	5	0	1
L:L:?1	R:R:W75	13.23	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:N93	4.56	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F96	13.13	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F161	6.06	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L166	5.74	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:E169	8.79	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:Y240	4.86	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:T243	2.45	1	Yes	No	0	5	0	1
L:L:?1	R:R:S247	12.45	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y251	3.89	1	Yes	Yes	0	4	0	1
L:L:?1	R:R:L266	3.44	1	Yes	No	0	7	0	1
L:L:?1	R:R:S270	4.98	1	Yes	No	0	8	0	1
R:R:S95	R:R:T64	6.4	1	No	Yes	5	8	2	2
R:R:F96	R:R:T64	3.89	1	Yes	Yes	6	8	1	2
R:R:F96	R:R:L71	2.44	1	Yes	Yes	6	7	1	1
R:R:L71	R:R:S270	3	1	Yes	No	7	8	1	1
R:R:L74	R:R:W75	4.56	1	No	Yes	5	4	1	1
R:R:L74	R:R:Y89	4.69	1	No	Yes	5	5	1	2
R:R:S157	R:R:W75	2.47	1	Yes	Yes	5	4	2	1
R:R:S247	R:R:W75	2.47	1	No	Yes	5	4	1	1
R:R:A250	R:R:W75	2.59	0	No	Yes	4	4	2	1
R:R:L266	R:R:W75	3.42	1	No	Yes	7	4	1	1
R:R:S157	R:R:Y89	3.82	1	Yes	Yes	5	5	2	2
R:R:F161	R:R:Y89	5.16	1	Yes	Yes	5	5	1	2
R:R:F161	R:R:L90	6.09	1	Yes	No	5	5	1	2
R:R:L97	R:R:N93	4.12	0	No	Yes	7	6	2	1
R:R:F161	R:R:N93	2.42	1	Yes	Yes	5	6	1	1
R:R:N93	R:R:Y165	5.81	1	Yes	Yes	6	7	1	2
R:R:E169	R:R:N93	10.52	1	Yes	Yes	6	6	1	1
R:R:F96	R:R:S95	6.61	1	Yes	No	6	5	1	2
R:R:F96	R:R:Y240	9.28	1	Yes	Yes	6	7	1	1
R:R:F96	R:R:S270	6.61	1	Yes	No	6	8	1	1
R:R:L100	R:R:W237	4.56	1	Yes	Yes	8	8	2	2
R:R:L100	R:R:Y240	2.34	1	Yes	Yes	8	7	2	1
R:R:F138	R:R:Y165	7.22	1	Yes	Yes	5	7	2	2
R:R:E169	R:R:F138	3.5	1	Yes	Yes	6	5	1	2
R:R:Q158	R:R:S157	8.66	1	No	Yes	3	5	2	2
R:R:S157	R:R:Y251	2.54	1	Yes	Yes	5	4	2	1
R:R:Q158	R:R:Y251	6.76	1	No	Yes	3	4	2	1
R:R:F161	R:R:I160	5.02	1	Yes	No	5	5	1	2
R:R:F161	R:R:Y165	7.22	1	Yes	Yes	5	7	1	2
R:R:A163	R:R:Y251	2.67	0	No	Yes	4	4	2	1
R:R:E169	R:R:Y165	12.35	1	Yes	Yes	6	7	1	2
R:R:E169	R:R:L166	6.63	1	Yes	Yes	6	5	1	1
R:R:L166	R:R:V170	2.98	1	Yes	Yes	5	4	1	2
R:R:L166	R:R:Y251	8.21	1	Yes	Yes	5	4	1	1
R:R:L244	R:R:V170	4.47	0	No	Yes	5	4	2	2
R:R:W237	R:R:Y240	6.75	1	Yes	Yes	8	7	2	1
R:R:L244	R:R:Y240	4.69	0	No	Yes	5	7	2	1
R:R:A273	R:R:Y240	5.34	0	No	Yes	9	7	2	1
R:R:L266	R:R:T243	4.42	1	No	No	7	5	1	1
R:R:G269	R:R:T243	5.46	0	No	No	9	5	2	1
R:R:L71	R:R:P72	1.64	1	Yes	No	7	6	1	2
R:R:A139	R:R:N93	1.56	0	No	Yes	7	6	2	1
R:R:L263	R:R:W75	1.14	0	No	Yes	5	4	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XTQ_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.34
Number of Linked Nodes	242
Number of Links	284
Number of Hubs	37
Number of Links mediated by Hubs	149
Number of Communities	8
Number of Nodes involved in Communities	55
Number of Links involved in Communities	82

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	49176
Length Of Smallest Path	3
Average Path Length	12.4659
Length of Longest Path	29
Minimum Path Strength	1.34
Average Path Strength	4.65006
Maximum Path Strength	15.64
Minimum Path Correlation	0.7
Average Path Correlation	0.935967
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5
Average % Of Corr. Nodes	56.8663
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	52.5141
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of signaling • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • cell-cell signaling • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled bile acid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • bicellular tight junction assembly • regulation of bicellular tight junction assembly • regulation of cellular component organization • tight junction organization • apical junction assembly • regulation of cellular component biogenesis • cellular component organization • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • cholangiocyte proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cholangiocyte proliferation • regulation of cell population proliferation • positive regulation of cholangiocyte proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • cellular response to bile acid • response to bile acid • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	H8I
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	H8I
Name	[2-(2,5-Dichloro-phenoxy)-pyridin-3-yl]-(3,4-dihydro-2H-quinolin-1-yl)-methanone
Synonyms
Identifier
Formula	C21 H16 Cl2 N2 O2
Molecular Weight	399.27
SMILES
PubChem	46195848
Formal Charge	0
Total Atoms	43
Total Chiral Atoms	0
Total Bonds	46
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDU6
Sequence	>7XTQ_nogp_Chain_R L S L A L A S L I I T A N L L L A L G I A W D R R L R S P P A G C F F L S L L L A G L L T G L A L P T L P G L W N Q S R R G Y W S C L L V Y L A P N F S F L S L L A N L L L V H G E R Y M A V L R P L Q P P G S I R L A L L L T W A G P L L F A S L P A L G W N H W T P G A N C S S Q A I F P A P Y L Y L E V Y G L L L P A V G A A A F L S V R V L A T A H R Q L Q D I C R L E R A V C R D E P S A L A R A L T W R Q A R A Q A G A M L L F G L C W G P Y V A T L L L S V L A Y E Q R P P L G P G T L L S L L S L G S A S A A A V P V A M G L G D Q R Y T A P W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7BW0	A	Steroid	Bile Acid	GPBA	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.9	2020-09-02	doi.org/10.1038/s41392-020-00262-z
	7BW0 (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	-	-		3.9	2020-09-02	doi.org/10.1038/s41392-020-00262-z
	7CFM	A	Steroid	Bile Acid	GPBA	Homo sapiens	P395	-	Gs/β1/γ2	3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7CFM (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	P395	-		3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7CFN	A	Steroid	Bile Acid	GPBA	Homo sapiens	INT-777	-	Gs/β1/γ2	3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7CFN (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	INT-777	-		3	2020-09-09	doi.org/10.1038/s41586-020-2569-1
	7XTQ	A	Steroid	Bile Acid	GPBA	Homo sapiens	R399	-	Gs/β1/γ2	3.2	2022-07-06	doi.org/10.1073/pnas.2117054119
	7XTQ (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	R399	-		3.2	2022-07-06	doi.org/10.1073/pnas.2117054119
	9GYO	A	Steroid	Bile acid	GPBA	Homo sapiens	P395	-	chim(NtGi1-Gs)/β1/γ2	2.5	2024-10-09	To be published
	9GYO (No Gprot)	A	Steroid	Bile acid	GPBA	Homo sapiens	P395	-		2.5	2024-10-09	To be published

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