psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L22	R:R:S21	3	No	Yes	4	3	7
2	R:R:P69	R:R:S21	5.34	Yes	Yes	4	9	7
3	R:R:P72	R:R:S21	3.56	No	Yes	0	6	7
4	R:R:L22	R:R:P69	3.28	No	Yes	4	3	9
5	R:R:A271	R:R:L24	4.73	No	No	0	6	7
6	R:R:A25	R:R:L68	4.73	No	Yes	4	7	6
7	R:R:A25	R:R:P69	3.74	No	Yes	4	7	9
8	R:R:I28	R:R:N32	4.25	No	Yes	0	8	9
9	R:R:A275	R:R:I28	3.25	No	No	0	6	8
10	R:R:I29	R:R:L62	4.28	No	No	0	6	6
11	R:R:I29	R:R:L66	2.85	No	No	0	6	5
12	R:R:A31	R:R:V278	5.09	No	No	0	8	6
13	R:R:L58	R:R:N32	2.75	Yes	Yes	0	9	9
14	R:R:G61	R:R:N32	3.39	No	Yes	0	9	9
15	R:R:L62	R:R:N32	6.87	No	Yes	0	6	9
16	R:R:N32	R:R:V278	4.43	Yes	No	0	9	6
17	R:R:L33	R:R:L62	4.15	No	No	0	5	6
18	R:R:L34	R:R:W291	3.42	No	Yes	0	7	6
19	R:R:L35	R:R:L58	4.15	No	Yes	0	9	9
20	R:R:A36	R:R:L58	3.15	No	Yes	0	8	9
21	R:R:G38	R:R:W291	2.81	No	Yes	0	8	6
22	R:R:I39	R:R:R46	6.26	No	Yes	5	8	8
23	R:R:I39	R:R:L55	7.14	No	No	0	8	7
24	R:R:I39	R:R:Y287	4.84	No	Yes	5	8	7
25	R:R:D42	R:R:L45	12.21	No	No	5	7	8
26	R:R:D42	R:R:R46	8.34	No	Yes	5	7	8
27	R:R:L45	R:R:R46	3.64	No	Yes	5	8	8
28	R:R:G51	R:R:R46	3	No	Yes	0	8	8
29	R:R:R46	R:R:Y287	5.14	Yes	Yes	5	8	7
30	R:R:P48	R:R:S47	3.56	No	No	0	3	7
31	R:R:F53	R:R:P49	4.33	Yes	Yes	2	8	7
32	R:R:E109	R:R:P49	3.14	No	Yes	2	9	7
33	R:R:I124	R:R:P49	8.47	Yes	Yes	2	6	7
34	R:R:C52	R:R:I124	3.27	No	Yes	0	3	6
35	R:R:F53	R:R:L105	15.83	Yes	No	0	8	6
36	R:R:E109	R:R:F53	5.83	No	Yes	2	9	8
37	R:R:F53	R:R:I124	2.51	Yes	Yes	2	8	6
38	R:R:A127	R:R:F53	4.16	No	Yes	0	5	8
39	R:R:F53	R:R:L128	4.87	Yes	No	2	8	7
40	R:R:F54	R:R:L58	4.87	Yes	Yes	0	8	9
41	R:R:F54	R:R:M280	2.49	Yes	No	0	8	8
42	R:R:F54	R:R:G281	4.52	Yes	No	0	8	7
43	R:R:F54	R:R:Y287	11.35	Yes	Yes	0	8	7
44	R:R:N102	R:R:S56	7.45	Yes	No	2	8	9
45	R:R:L128	R:R:S56	3	No	No	2	7	9
46	R:R:S56	R:R:W132	6.18	No	Yes	2	9	9
47	R:R:L57	R:R:N102	2.75	Yes	Yes	0	9	8
48	R:R:L103	R:R:L57	2.77	Yes	Yes	0	9	9
49	R:R:L57	R:R:V106	5.96	Yes	No	0	9	9
50	R:R:L57	R:R:P277	6.57	Yes	No	0	9	9
51	R:R:L59	R:R:L63	4.15	No	No	0	7	6
52	R:R:A60	R:R:S98	3.42	Yes	No	2	9	7
53	R:R:A60	R:R:L99	3.15	Yes	Yes	0	9	9
54	R:R:A60	R:R:N102	4.69	Yes	Yes	2	9	8
55	R:R:A60	R:R:W132	2.59	Yes	Yes	2	9	9
56	R:R:S95	R:R:T64	4.8	No	Yes	0	5	8
57	R:R:F96	R:R:T64	5.19	Yes	Yes	0	6	8
58	R:R:L99	R:R:T64	7.37	Yes	Yes	0	9	8
59	R:R:A274	R:R:T64	3.36	No	Yes	0	8	8
60	R:R:A67	R:R:P92	3.74	No	Yes	0	7	6
61	R:R:A67	R:R:S95	3.42	No	No	0	7	5
62	R:R:L68	R:R:P69	3.28	Yes	Yes	4	6	9
63	R:R:L71	R:R:S270	3	No	No	0	7	8
64	L:L:?1	R:R:L71	12.06	Yes	No	0	0	7
65	R:R:L263	R:R:P72	4.93	No	No	0	5	6
66	R:R:L74	R:R:V88	2.98	No	No	0	5	5
67	R:R:L74	R:R:Y89	3.52	No	Yes	0	5	5
68	R:R:S247	R:R:W75	3.71	No	Yes	1	5	4
69	R:R:A250	R:R:W75	2.59	No	Yes	0	4	4
70	R:R:L266	R:R:W75	3.42	No	Yes	0	7	4
71	L:L:?1	R:R:W75	14.89	Yes	Yes	1	0	4
72	R:R:N154	R:R:Q77	6.6	No	No	0	3	4
73	R:R:Q77	R:R:S156	2.89	No	No	0	4	4
74	R:R:R80	R:R:S78	3.95	Yes	No	0	4	3
75	R:R:N154	R:R:R79	10.85	No	No	0	3	3
76	R:R:R80	R:R:S84	5.27	Yes	No	0	4	3
77	R:R:C85	R:R:R80	4.18	No	Yes	0	9	4
78	R:R:R80	R:R:V88	3.92	Yes	No	0	4	5
79	R:R:W83	R:R:Y82	13.5	No	No	0	1	4
80	R:R:L86	R:R:Y82	5.86	No	No	0	6	4
81	R:R:W149	R:R:Y82	29.9	Yes	No	0	3	4
82	R:R:C85	R:R:Y89	2.69	No	Yes	0	9	5
83	R:R:C155	R:R:C85	7.28	No	No	0	9	9
84	R:R:L86	R:R:L90	5.54	No	No	0	6	5
85	R:R:A143	R:R:L86	4.73	No	No	0	6	6
86	R:R:S156	R:R:Y89	2.54	No	Yes	0	4	5
87	R:R:S157	R:R:Y89	11.45	No	Yes	0	5	5
88	R:R:I160	R:R:Y89	9.67	No	Yes	0	5	5
89	R:R:F161	R:R:Y89	4.13	Yes	Yes	0	5	5
90	R:R:L90	R:R:P142	6.57	No	Yes	0	5	8
91	L:L:?1	R:R:P92	3.58	Yes	Yes	0	0	6
92	R:R:L97	R:R:N93	4.12	No	Yes	1	7	6
93	R:R:F161	R:R:N93	6.04	Yes	Yes	1	5	6
94	R:R:N93	R:R:Y165	5.81	Yes	Yes	1	6	7
95	R:R:E169	R:R:N93	11.83	Yes	Yes	1	6	6
96	R:R:F94	R:R:W132	3.01	Yes	Yes	0	5	9
97	R:R:F94	R:R:P135	2.89	Yes	Yes	0	5	8
98	R:R:F94	R:R:L136	3.65	Yes	No	0	5	5
99	R:R:F96	R:R:S270	3.96	Yes	No	0	6	8
100	R:R:A273	R:R:F96	2.77	No	Yes	0	9	6
101	L:L:?1	R:R:F96	15.92	Yes	Yes	0	0	6
102	R:R:L97	R:R:P135	3.28	No	Yes	0	7	8
103	R:R:E169	R:R:L97	5.3	Yes	No	1	6	7
104	R:R:S98	R:R:W132	6.18	No	Yes	2	7	9
105	R:R:P135	R:R:S98	3.56	Yes	No	0	8	7
106	R:R:L100	R:R:L99	4.15	Yes	Yes	0	8	9
107	R:R:L99	R:R:P277	3.28	Yes	No	0	9	9
108	R:R:L100	R:R:L174	2.77	Yes	Yes	1	8	7
109	R:R:A177	R:R:L100	4.73	No	Yes	0	8	8
110	R:R:L100	R:R:W237	5.69	Yes	Yes	1	8	8
111	R:R:L100	R:R:Y240	4.69	Yes	Yes	1	8	7
112	R:R:A101	R:R:P135	3.74	No	Yes	0	5	8
113	R:R:N102	R:R:T131	4.39	Yes	No	0	8	6
114	R:R:N102	R:R:W132	13.56	Yes	Yes	2	8	9
115	R:R:H107	R:R:L103	5.14	Yes	Yes	1	9	9
116	R:R:L103	R:R:W237	5.69	Yes	Yes	1	9	8
117	R:R:L103	R:R:M280	2.83	Yes	No	1	9	8
118	R:R:L105	R:R:T131	10.32	No	No	0	6	6
119	R:R:H107	R:R:R110	4.51	Yes	No	1	9	9
120	R:R:H107	R:R:S185	2.79	Yes	Yes	1	9	9
121	R:R:H107	R:R:M280	3.94	Yes	No	1	9	8
122	R:R:R110	R:R:S185	2.64	No	Yes	1	9	9
123	R:R:R110	R:R:V188	5.23	No	No	0	9	9
124	R:R:L115	R:R:Y111	9.38	Yes	Yes	3	6	9
125	R:R:L184	R:R:Y111	9.38	No	Yes	0	7	9
126	R:R:R187	R:R:Y111	6.17	No	Yes	3	6	9
127	R:R:V188	R:R:Y111	2.52	No	Yes	0	9	9
128	R:R:M112	R:R:R116	4.96	No	No	3	5	5
129	R:R:M112	R:R:Q119	5.44	No	No	3	5	5
130	R:R:L115	R:R:V114	2.98	Yes	No	3	6	8
131	R:R:V114	R:R:V188	4.81	No	No	0	8	9
132	R:R:T191	R:R:V114	3.17	No	No	3	6	8
133	R:R:L115	R:R:R187	7.29	Yes	No	3	6	6
134	R:R:L115	R:R:T191	7.37	Yes	No	3	6	6
135	R:R:Q119	R:R:R116	19.86	No	No	3	5	5
136	R:R:P120	R:R:Q119	4.74	No	No	0	8	5
137	R:R:L126	R:R:S123	4.5	No	No	0	3	6
138	R:R:I124	R:R:L128	2.85	Yes	No	2	6	7
139	R:R:G134	R:R:P135	4.06	No	Yes	0	2	8
140	R:R:L137	R:R:L141	2.77	No	No	0	4	5
141	R:R:F138	R:R:Y165	12.38	No	Yes	1	5	7
142	R:R:E169	R:R:F138	7	Yes	No	1	6	5
143	R:R:F138	R:R:L173	4.87	No	No	0	5	4
144	R:R:F161	R:R:P142	2.89	Yes	Yes	1	5	8
145	R:R:P142	R:R:Y165	13.91	Yes	Yes	1	8	7
146	R:R:P162	R:R:W146	6.76	Yes	No	1	5	6
147	R:R:W146	R:R:Y165	5.79	No	Yes	1	6	7
148	R:R:N147	R:R:W149	4.52	No	Yes	0	8	3
149	R:R:H148	R:R:P162	4.58	No	Yes	0	4	5
150	R:R:P151	R:R:W149	5.4	No	Yes	0	2	3
151	R:R:P151	R:R:T150	3.5	No	No	0	2	3
152	R:R:C155	R:R:I160	3.27	No	No	0	9	5
153	R:R:Q158	R:R:S156	5.78	No	No	0	3	4
154	R:R:Q158	R:R:Y251	3.38	No	No	0	3	4
155	R:R:F161	R:R:Y165	4.13	Yes	Yes	1	5	7
156	L:L:?1	R:R:F161	5.31	Yes	Yes	1	0	5
157	R:R:P162	R:R:Y165	2.78	Yes	Yes	1	5	7
158	R:R:E169	R:R:Y165	5.61	Yes	Yes	1	6	7
159	R:R:L166	R:R:V170	2.98	No	Yes	0	5	4
160	R:R:L166	R:R:Y251	8.21	No	No	1	5	4
161	L:L:?1	R:R:L166	14.07	Yes	No	1	0	5
162	R:R:Y167	R:R:Y171	2.98	No	No	0	6	5
163	R:R:V248	R:R:Y167	2.52	No	No	0	6	6
164	R:R:E252	R:R:Y167	6.73	No	No	0	1	6
165	R:R:E169	R:R:L174	3.98	Yes	Yes	1	6	7
166	L:L:?1	R:R:E169	10.58	Yes	Yes	1	0	6
167	R:R:V170	R:R:Y171	6.31	Yes	No	0	4	5
168	R:R:L244	R:R:V170	4.47	No	Yes	0	5	4
169	R:R:V170	R:R:V248	4.81	Yes	No	0	4	6
170	R:R:G172	R:R:P176	4.06	No	No	0	4	3
171	R:R:L174	R:R:L244	4.15	Yes	No	0	7	5
172	L:L:?1	R:R:L174	4.02	Yes	Yes	1	0	7
173	R:R:L175	R:R:V241	2.98	No	No	0	6	6
174	R:R:V178	R:R:W237	3.68	No	Yes	0	7	8
175	R:R:A181	R:R:F233	2.77	No	Yes	0	8	9
176	R:R:F233	R:R:S185	3.96	Yes	Yes	0	9	9
177	R:R:L189	R:R:Q226	2.66	Yes	No	0	7	7
178	R:R:R194	R:R:T191	5.17	No	No	0	5	6
179	R:R:A192	R:R:Q222	4.55	No	No	0	9	7
180	R:R:H193	R:R:Q197	7.42	No	No	0	7	6
181	R:R:H193	R:R:Q226	3.71	No	No	0	7	7
182	R:R:D198	R:R:Q195	2.61	No	No	0	6	8
183	R:R:C200	R:R:L196	3.17	No	Yes	0	4	5
184	R:R:L196	R:R:L218	2.77	Yes	Yes	0	5	6
185	R:R:L196	R:R:T219	2.95	Yes	No	0	5	7
186	R:R:L196	R:R:Q222	5.32	Yes	No	0	5	7
187	R:R:D198	R:R:R201	5.96	No	No	0	6	5
188	R:R:E203	R:R:I199	2.73	No	No	0	3	7
189	R:R:I199	R:R:L218	2.85	No	Yes	0	7	6
190	R:R:C200	R:R:R204	2.79	No	No	0	4	4
191	R:R:E203	R:R:S212	7.19	No	No	0	3	3
192	R:R:E210	R:R:P211	6.29	No	No	0	2	3
193	R:R:L214	R:R:L218	6.92	No	Yes	0	3	6
194	R:R:L231	R:R:L235	2.77	No	No	0	5	4
195	R:R:F233	R:R:W237	8.02	Yes	Yes	0	9	8
196	R:R:W237	R:R:Y240	5.79	Yes	Yes	1	8	7
197	R:R:V276	R:R:W237	14.71	No	Yes	0	9	8
198	R:R:G238	R:R:P239	4.06	No	No	0	6	9
199	R:R:P239	R:R:S272	3.56	No	No	0	9	9
200	R:R:L244	R:R:Y240	4.69	No	Yes	0	5	7
201	R:R:A273	R:R:Y240	9.34	No	Yes	0	9	7
202	L:L:?1	R:R:Y240	3.41	Yes	Yes	1	0	7
203	R:R:L266	R:R:T243	2.95	No	No	0	7	5
204	R:R:G269	R:R:T243	5.46	No	No	0	9	5
205	L:L:?1	R:R:S247	7.63	Yes	No	1	0	5
206	R:R:A250	R:R:P256	3.74	No	Yes	0	4	4
207	L:L:?1	R:R:Y251	5.96	Yes	No	1	0	4
208	R:R:E252	R:R:R254	3.49	No	No	0	1	1
209	R:R:L262	R:R:P256	13.14	No	Yes	0	2	4
210	R:R:G258	R:R:P259	4.06	No	No	0	4	5
211	R:R:L262	R:R:L266	5.54	No	No	0	2	7
212	R:R:G269	R:R:S272	3.71	No	No	0	9	9
213	R:R:P277	R:R:V276	3.53	No	No	0	9	9
214	R:R:L282	R:R:T288	2.95	No	No	0	6	8
215	R:R:D284	R:R:Y287	9.2	No	Yes	0	8	7
216	R:R:R286	R:R:Y287	7.2	No	Yes	0	5	7
217	R:R:P290	R:R:W291	9.46	No	Yes	0	6	6
218	R:R:F183	R:R:L184	2.44	No	No	0	3	7
219	R:R:L55	R:R:R43	2.43	No	No	0	7	7
220	R:R:L218	R:R:R221	2.43	Yes	No	0	6	8
221	R:R:M112	R:R:Y111	2.39	No	Yes	3	5	9
222	R:R:L59	R:R:W132	2.28	No	Yes	0	7	9
223	R:R:L232	R:R:W237	2.28	No	Yes	0	6	8
224	R:R:P48	R:R:P49	1.95	No	Yes	0	3	7
225	R:R:A50	R:R:G51	1.95	No	No	0	8	8
226	R:R:A274	R:R:G65	1.95	No	No	0	8	9
227	R:R:P120	R:R:P121	1.95	No	No	0	8	3
228	R:R:P162	R:R:P164	1.95	Yes	No	0	5	4
229	R:R:P255	R:R:P256	1.95	No	Yes	0	4	4
230	R:R:A91	R:R:P92	1.87	No	Yes	0	3	6
231	R:R:A163	R:R:P164	1.87	No	No	0	4	4
232	R:R:A289	R:R:P290	1.87	No	No	0	4	6
233	R:R:G258	R:R:T261	1.82	No	No	0	4	5
234	R:R:A215	R:R:C200	1.81	No	No	0	4	4
235	R:R:P92	R:R:T70	1.75	Yes	No	0	6	4
236	R:R:G65	R:R:L68	1.71	No	Yes	0	9	6
237	R:R:G108	R:R:L184	1.71	No	No	0	6	7
238	R:R:G145	R:R:L144	1.71	No	No	0	7	4
239	R:R:G172	R:R:L173	1.71	No	No	0	4	4
240	R:R:A229	R:R:S185	1.71	No	Yes	0	8	9
241	R:R:C207	R:R:V206	1.71	No	No	0	4	4
242	R:R:C236	R:R:V276	1.71	No	No	0	8	9
243	R:R:G258	R:R:L257	1.71	No	No	0	4	1
244	R:R:G260	R:R:L263	1.71	No	No	0	1	5
245	R:R:A153	R:R:T150	1.68	No	No	0	1	3
246	R:R:L141	R:R:P142	1.64	No	Yes	0	5	8
247	R:R:L175	R:R:P176	1.64	No	No	0	6	3
248	R:R:L246	R:R:P256	1.64	No	Yes	0	5	4
249	R:R:L257	R:R:P256	1.64	No	Yes	0	1	4
250	R:R:S21	R:R:S267	1.63	Yes	No	0	7	6
251	R:R:A23	R:R:L20	1.58	No	No	0	3	4
252	R:R:A271	R:R:L68	1.58	No	Yes	0	6	6
253	R:R:A180	R:R:L104	1.58	No	No	0	5	7
254	R:R:A225	R:R:L189	1.58	No	Yes	0	8	7
255	R:R:A113	R:R:E109	1.51	No	No	0	9	9
256	R:R:F233	R:R:G234	1.51	Yes	No	0	9	5
257	R:R:G81	R:R:R80	1.5	No	Yes	0	5	4
258	R:R:L189	R:R:S185	1.5	Yes	Yes	0	7	9
259	R:R:L268	R:R:S272	1.5	No	No	0	8	9
260	R:R:L245	R:R:V241	1.49	No	No	0	5	6
261	R:R:L282	R:R:V278	1.49	No	No	0	6	6
262	R:R:L265	R:R:T243	1.47	No	No	0	7	5
263	R:R:P117	R:R:R116	1.44	No	No	0	9	5
264	R:R:G38	R:R:W41	1.41	No	No	0	8	4
265	R:R:A139	R:R:F94	1.39	No	Yes	0	7	5
266	R:R:A182	R:R:F233	1.39	No	Yes	0	5	9
267	R:R:L20	R:R:L24	1.38	No	No	0	4	7
268	R:R:A213	R:R:R216	1.38	No	No	0	3	3
269	R:R:L189	R:R:Q222	1.33	Yes	No	0	7	7
270	R:R:A159	R:R:W149	1.3	No	Yes	0	2	3
271	R:R:R292	R:R:T288	1.29	No	No	0	7	8
272	R:R:D209	R:R:R208	1.19	No	No	0	1	1
273	R:R:L37	R:R:W41	1.14	No	No	0	4	4
274	R:R:R201	R:R:R204	1.07	No	No	0	5	4
275	R:R:R221	R:R:R224	1.07	No	No	0	8	7
276	R:R:R292	R:R:W291	1	No	Yes	0	7	6

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:S21	3.3825	4	4	7
2	R:R:N32	4.338	5	0	9
3	R:R:R46	5.276	5	5	8
4	R:R:P49	4.4725	4	2	7
5	R:R:F53	6.255	6	2	8
6	R:R:F54	5.8075	4	0	8
7	R:R:L57	4.5125	4	0	9
8	R:R:L58	3.73	4	0	9
9	R:R:A60	3.4625	4	2	9
10	R:R:T64	5.18	4	0	8
11	R:R:L68	2.825	4	4	6
12	R:R:P69	3.91	4	4	9
13	R:R:W75	6.1525	4	1	4
14	R:R:R80	3.764	5	0	4
15	R:R:Y89	5.66667	6	0	5
16	R:R:P92	2.735	4	0	6
17	R:R:N93	6.95	4	1	6
18	R:R:F94	2.735	4	0	5
19	R:R:F96	6.96	4	0	6
20	R:R:L99	4.4875	4	0	9
21	R:R:L100	4.406	5	1	8
22	R:R:N102	6.568	5	2	8
23	R:R:L103	4.1075	4	1	9
24	R:R:H107	4.095	4	1	9
25	R:R:Y111	5.968	5	3	9
26	R:R:L115	6.755	4	3	6
27	R:R:I124	4.275	4	2	6
28	R:R:W132	5.63333	6	2	9
29	R:R:P135	3.506	5	0	8
30	R:R:P142	6.2525	4	1	8
31	R:R:W149	10.28	4	0	3
32	R:R:F161	4.5	5	1	5
33	R:R:P162	4.0175	4	1	5
34	R:R:Y165	7.20143	7	1	7
35	R:R:E169	7.38333	6	1	6
36	R:R:V170	4.6425	4	0	4
37	R:R:L174	3.73	4	1	7
38	R:R:S185	2.52	5	1	9
39	R:R:L189	1.7675	4	0	7
40	R:R:L196	3.5525	4	0	5
41	R:R:L218	3.7425	4	0	6
42	R:R:F233	3.53	5	0	9
43	R:R:W237	6.55143	7	1	8
44	R:R:Y240	5.584	5	1	7
45	R:R:P256	4.422	5	0	4
46	R:R:Y287	7.546	5	5	7
47	R:R:W291	4.1725	4	0	6
48	L:L:?1	8.85727	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A271	R:R:L68	11.0781	1.58	No	Yes	0	6	6
2	R:R:L68	R:R:P69	19.1677	3.28	Yes	Yes	4	6	9
3	R:R:L58	R:R:N32	44.4971	2.75	Yes	Yes	0	9	9
4	R:R:F54	R:R:L58	50.6186	4.87	Yes	Yes	0	8	9
5	R:R:F54	R:R:M280	75.474	2.49	Yes	No	0	8	8
6	R:R:L103	R:R:M280	63.3033	2.83	Yes	No	1	9	8
7	R:R:L103	R:R:L57	49.51	2.77	Yes	Yes	0	9	9
8	R:R:L57	R:R:P277	10.2828	6.57	Yes	No	0	9	9
9	R:R:L99	R:R:P277	11.6163	3.28	Yes	No	0	9	9
10	R:R:L99	R:R:T64	44.9148	7.37	Yes	Yes	0	9	8
11	R:R:A274	R:R:T64	40.2394	3.36	No	Yes	0	8	8
12	R:R:A274	R:R:G65	37.6687	1.95	No	No	0	8	9
13	R:R:G65	R:R:L68	35.0819	1.71	No	Yes	0	9	6
14	R:R:L103	R:R:W237	79.6031	5.69	Yes	Yes	1	9	8
15	R:R:L100	R:R:W237	34.3027	5.69	Yes	Yes	1	8	8
16	R:R:L100	R:R:L99	51.0845	4.15	Yes	Yes	0	8	9
17	R:R:N32	R:R:V278	27.4663	4.43	Yes	No	0	9	6
18	R:R:L282	R:R:V278	23.0479	1.49	No	No	0	6	6
19	R:R:L282	R:R:T288	20.8146	2.95	No	No	0	6	8
20	R:R:R292	R:R:T288	18.5652	1.29	No	No	0	7	8
21	R:R:R292	R:R:W291	16.2998	1	No	Yes	0	7	6
22	R:R:F54	R:R:Y287	25.2651	11.35	Yes	Yes	0	8	7
23	R:R:R46	R:R:Y287	11.6003	5.14	Yes	Yes	5	8	7
24	R:R:A60	R:R:L99	52.153	3.15	Yes	Yes	0	9	9
25	R:R:A60	R:R:N102	34.2545	4.69	Yes	Yes	2	9	8
26	R:R:N102	R:R:S56	29.9325	7.45	Yes	No	2	8	9
27	R:R:L128	R:R:S56	65.6973	3	No	No	2	7	9
28	R:R:F53	R:R:L128	35.4434	4.87	Yes	No	2	8	7
29	R:R:F53	R:R:P49	21.6822	4.33	Yes	Yes	2	8	7
30	R:R:P48	R:R:P49	24.6546	1.95	No	Yes	0	3	7
31	R:R:A60	R:R:W132	19.2882	2.59	Yes	Yes	2	9	9
32	R:R:S56	R:R:W132	40.7053	6.18	No	Yes	2	9	9
33	R:R:N102	R:R:T131	26.1247	4.39	Yes	No	0	8	6
34	R:R:L105	R:R:T131	20.6218	10.32	No	No	0	6	6
35	R:R:F53	R:R:L105	15.1189	15.83	Yes	No	0	8	6
36	R:R:I124	R:R:L128	25.2972	2.85	Yes	No	2	6	7
37	R:R:I124	R:R:P49	15.2555	8.47	Yes	Yes	2	6	7
38	R:R:P48	R:R:S47	12.3313	3.56	No	No	0	3	7
39	R:R:E109	R:R:F53	14.4843	5.83	No	Yes	2	9	8
40	R:R:F96	R:R:T64	27.0325	5.19	Yes	Yes	0	6	8
41	L:L:?1	R:R:F96	28.6391	15.92	Yes	Yes	0	0	6
42	L:L:?1	R:R:P92	12.6446	3.58	Yes	Yes	0	0	6
43	L:L:?1	R:R:F161	58.6922	5.31	Yes	Yes	1	0	5
44	R:R:F161	R:R:Y89	35.8772	4.13	Yes	Yes	0	5	5
45	L:L:?1	R:R:W75	59.6722	14.89	Yes	Yes	1	0	4
46	R:R:A250	R:R:W75	26.679	2.59	No	Yes	0	4	4
47	R:R:L266	R:R:W75	30.1816	3.42	No	Yes	0	7	4
48	R:R:Q77	R:R:S156	11.7288	2.89	No	No	0	4	4
49	L:L:?1	R:R:Y251	12.4598	5.96	Yes	No	1	0	4
50	R:R:C85	R:R:Y89	14.0746	2.69	No	Yes	0	9	5
51	R:R:F161	R:R:P142	30.4708	2.89	Yes	Yes	1	5	8
52	R:R:L90	R:R:P142	35.6041	6.57	No	Yes	0	5	8
53	R:R:L86	R:R:L90	32.447	5.54	No	No	0	6	5
54	R:R:L86	R:R:Y82	26.0845	5.86	No	No	0	6	4
55	R:R:W149	R:R:Y82	19.6578	29.9	Yes	No	0	3	4
56	L:L:?1	R:R:E169	32.1979	10.58	Yes	Yes	1	0	6
57	R:R:E169	R:R:L97	25.7873	5.3	Yes	No	1	6	7
58	R:R:F161	R:R:N93	14.661	6.04	Yes	Yes	1	5	6
59	R:R:F161	R:R:Y165	10.1623	4.13	Yes	Yes	1	5	7
60	R:R:E169	R:R:Y165	24.3252	5.61	Yes	Yes	1	6	7
61	R:R:F94	R:R:W132	22.847	3.01	Yes	Yes	0	5	9
62	R:R:P135	R:R:S98	26.3335	3.56	Yes	No	0	8	7
63	R:R:L100	R:R:L174	34.5276	2.77	Yes	Yes	1	8	7
64	L:L:?1	R:R:L174	13.5443	4.02	Yes	Yes	1	0	7
65	L:L:?1	R:R:Y240	99.7831	3.41	Yes	Yes	1	0	7
66	R:R:L100	R:R:Y240	17.1835	4.69	Yes	Yes	1	8	7
67	R:R:H107	R:R:L103	40.7616	5.14	Yes	Yes	1	9	9
68	R:R:H107	R:R:R110	35.7085	4.51	Yes	No	1	9	9
69	R:R:F233	R:R:W237	57.9933	8.02	Yes	Yes	0	9	8
70	R:R:F233	R:R:S185	53.0768	3.96	Yes	Yes	0	9	9
71	R:R:R110	R:R:S185	25.008	2.64	No	Yes	1	9	9
72	R:R:R110	R:R:V188	57.4871	5.23	No	No	0	9	9
73	R:R:V188	R:R:Y111	40.7535	2.52	No	Yes	0	9	9
74	R:R:V114	R:R:V188	13.6327	4.81	No	No	0	8	9
75	R:R:L184	R:R:Y111	10.4756	9.38	No	Yes	0	7	9
76	R:R:M112	R:R:Y111	20.8146	2.39	No	Yes	3	5	9
77	R:R:M112	R:R:Q119	10.4274	5.44	No	No	3	5	5
78	R:R:E169	R:R:F138	19.8024	7	Yes	No	1	6	5
79	R:R:F138	R:R:L173	18.999	4.87	No	No	0	5	4
80	R:R:P162	R:R:Y165	19.8827	2.78	Yes	Yes	1	5	7
81	L:L:?1	R:R:L166	10.5238	14.07	Yes	No	1	0	5
82	R:R:V170	R:R:Y171	11.6324	6.31	Yes	No	0	4	5
83	R:R:V170	R:R:V248	11.7931	4.81	Yes	No	0	4	6
84	R:R:E252	R:R:Y167	11.6726	6.73	No	No	0	1	6
85	R:R:L244	R:R:Y240	15.7053	4.69	No	Yes	0	5	7
86	R:R:G172	R:R:L173	15.8981	1.71	No	No	0	4	4
87	R:R:G172	R:R:P176	12.749	4.06	No	No	0	4	3
88	R:R:L189	R:R:S185	46.1038	1.5	Yes	Yes	0	7	9
89	R:R:L189	R:R:Q222	36.3994	1.33	Yes	No	0	7	7
90	R:R:C200	R:R:L196	13.3596	3.17	No	Yes	0	4	5
91	R:R:L196	R:R:Q222	32.4309	5.32	Yes	No	0	5	7
92	R:R:L196	R:R:L218	15.7053	2.77	Yes	Yes	0	5	6
93	R:R:G269	R:R:S272	13.8094	3.71	No	No	0	9	9
94	R:R:G269	R:R:T243	17.2236	5.46	No	No	0	9	5
95	R:R:L266	R:R:T243	24.0039	2.95	No	No	0	7	5
96	R:R:A250	R:R:P256	23.5058	3.74	No	Yes	0	4	4
97	R:R:G258	R:R:L257	10.3792	1.71	No	No	0	4	1
98	R:R:L257	R:R:P256	13.8094	1.64	No	Yes	0	1	4
99	R:R:P69	R:R:S21	13.7693	5.34	Yes	Yes	4	9	7
100	R:R:L57	R:R:N102	38.8657	2.75	Yes	Yes	0	9	8
101	R:R:N102	R:R:W132	13.4238	13.56	Yes	Yes	2	8	9
102	R:R:S98	R:R:W132	20.0594	6.18	No	Yes	2	7	9
103	R:R:W237	R:R:Y240	100	5.79	Yes	Yes	1	8	7
104	R:R:E169	R:R:L174	19.1115	3.98	Yes	Yes	1	6	7
105	R:R:F94	R:R:P135	22.5578	2.89	Yes	Yes	0	5	8
106	R:R:H107	R:R:M280	13.9621	3.94	Yes	No	1	9	8
107	R:R:H107	R:R:S185	17.4084	2.79	Yes	Yes	1	9	9
108	R:R:L244	R:R:V170	18.501	4.47	No	Yes	0	5	4
109	R:R:L97	R:R:P135	45.188	3.28	No	Yes	0	7	8
110	R:R:L97	R:R:N93	21.7625	4.12	No	Yes	1	7	6
111	R:R:P142	R:R:Y165	14.5003	13.91	Yes	Yes	1	8	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F96	R:R:T64	5.19	0	Yes	Yes	6	8	1	2
R:R:A67	R:R:P92	3.74	0	No	Yes	7	6	2	1
R:R:L71	R:R:S270	3	0	No	No	7	8	1	2
L:L:?1	R:R:L71	12.06	1	Yes	No	0	7	0	1
R:R:S247	R:R:W75	3.71	1	No	Yes	5	4	1	1
R:R:A250	R:R:W75	2.59	0	No	Yes	4	4	2	1
R:R:L266	R:R:W75	3.42	0	No	Yes	7	4	2	1
L:L:?1	R:R:W75	14.89	1	Yes	Yes	0	4	0	1
R:R:F161	R:R:Y89	4.13	1	Yes	Yes	5	5	1	2
L:L:?1	R:R:P92	3.58	1	Yes	Yes	0	6	0	1
R:R:L97	R:R:N93	4.12	1	No	Yes	7	6	2	2
R:R:F161	R:R:N93	6.04	1	Yes	Yes	5	6	1	2
R:R:N93	R:R:Y165	5.81	1	Yes	Yes	6	7	2	2
R:R:E169	R:R:N93	11.83	1	Yes	Yes	6	6	1	2
R:R:F96	R:R:S270	3.96	0	Yes	No	6	8	1	2
R:R:A273	R:R:F96	2.77	0	No	Yes	9	6	2	1
L:L:?1	R:R:F96	15.92	1	Yes	Yes	0	6	0	1
R:R:E169	R:R:L97	5.3	1	Yes	No	6	7	1	2
R:R:L100	R:R:L174	2.77	1	Yes	Yes	8	7	2	1
R:R:L100	R:R:W237	5.69	1	Yes	Yes	8	8	2	2
R:R:L100	R:R:Y240	4.69	1	Yes	Yes	8	7	2	1
R:R:F138	R:R:Y165	12.38	1	No	Yes	5	7	2	2
R:R:E169	R:R:F138	7	1	Yes	No	6	5	1	2
R:R:F161	R:R:P142	2.89	1	Yes	Yes	5	8	1	2
R:R:P142	R:R:Y165	13.91	1	Yes	Yes	8	7	2	2
R:R:Q158	R:R:Y251	3.38	0	No	No	3	4	2	1
R:R:F161	R:R:Y165	4.13	1	Yes	Yes	5	7	1	2
L:L:?1	R:R:F161	5.31	1	Yes	Yes	0	5	0	1
R:R:E169	R:R:Y165	5.61	1	Yes	Yes	6	7	1	2
R:R:L166	R:R:V170	2.98	1	No	Yes	5	4	1	2
R:R:L166	R:R:Y251	8.21	1	No	No	5	4	1	1
L:L:?1	R:R:L166	14.07	1	Yes	No	0	5	0	1
R:R:E169	R:R:L174	3.98	1	Yes	Yes	6	7	1	1
L:L:?1	R:R:E169	10.58	1	Yes	Yes	0	6	0	1
R:R:L244	R:R:V170	4.47	0	No	Yes	5	4	2	2
R:R:L174	R:R:L244	4.15	1	Yes	No	7	5	1	2
L:L:?1	R:R:L174	4.02	1	Yes	Yes	0	7	0	1
R:R:W237	R:R:Y240	5.79	1	Yes	Yes	8	7	2	1
R:R:L244	R:R:Y240	4.69	0	No	Yes	5	7	2	1
R:R:A273	R:R:Y240	9.34	0	No	Yes	9	7	2	1
L:L:?1	R:R:Y240	3.41	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:S247	7.63	1	Yes	No	0	5	0	1
L:L:?1	R:R:Y251	5.96	1	Yes	No	0	4	0	1
R:R:A91	R:R:P92	1.87	0	No	Yes	3	6	2	1
R:R:P92	R:R:T70	1.75	0	Yes	No	6	4	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7CFM_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.49
Number of Linked Nodes	239
Number of Links	276
Number of Hubs	48
Number of Links mediated by Hubs	177
Number of Communities	5
Number of Nodes involved in Communities	51
Number of Links involved in Communities	73

Path Summary
Number Of Nodes in MetaPath	112
Number Of Links MetaPath	111
Number of Shortest Paths	45976
Length Of Smallest Path	3
Average Path Length	11.2329
Length of Longest Path	25
Minimum Path Strength	1.145
Average Path Strength	4.84663
Maximum Path Strength	21.7
Minimum Path Correlation	0.7
Average Path Correlation	0.933792
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.88235
Average % Of Corr. Nodes	59.2294
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	57.9079
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • adenylate cyclase activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • biological regulation • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of biological process • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • homeostatic process • positive regulation of biological process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • protein localization • regulation of localization • establishment of protein localization • nitrogen compound transport • localization • cellular macromolecule localization • regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • protein transport • regulation of cellular localization • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • cellular response to monoamine stimulus • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • protein binding • binding • enzyme binding • GTPase binding • protein-containing complex binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular process • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • signal transduction • cell communication • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • response to oxygen-containing compound • cellular response to oxygen-containing compound • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to chemical stimulus • cellular response to alcohol • response to hormone • response to chemical • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • synaptic signaling • cellular response to acetylcholine • cell-cell signaling • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • plasma membrane bounded cell projection • cell projection • photoreceptor cell cilium • vacuolar membrane • lytic vacuole • vacuole • lytic vacuole membrane • bounding membrane of organelle • lysosomal membrane • lysosome • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation • G protein-coupled bile acid receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • bicellular tight junction assembly • regulation of bicellular tight junction assembly • regulation of cellular component organization • tight junction organization • apical junction assembly • regulation of cellular component biogenesis • cellular component organization • cellular component biogenesis • regulation of cell junction assembly • cell junction organization • cellular component assembly • cell junction assembly • tight junction assembly • cellular component organization or biogenesis • cell-cell junction assembly • cell-cell junction organization • positive regulation of cell communication • positive regulation of signal transduction • positive regulation of biological process • regulation of signal transduction • positive regulation of response to stimulus • positive regulation of ERK1 and ERK2 cascade • regulation of intracellular signal transduction • positive regulation of cellular process • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • positive regulation of signaling • cholangiocyte proliferation • positive regulation of cell population proliferation • positive regulation of epithelial cell proliferation • regulation of cholangiocyte proliferation • regulation of cell population proliferation • positive regulation of cholangiocyte proliferation • regulation of epithelial cell proliferation • epithelial cell proliferation • cellular response to bile acid • response to bile acid • receptor complex
SCOP2	Domain Identifier	• Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FWX
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FWX
Name	2-(ethylamino)-6-[3-(4-propan-2-ylphenyl)propanoyl]-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine-4-carboxamide
Synonyms
Identifier
Formula	C22 H29 N5 O2
Molecular Weight	395.498
SMILES
PubChem	71541719
Formal Charge	0
Total Atoms	58
Total Chiral Atoms	0
Total Bonds	60
Total Aromatic Bonds	12


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	Q8TDU6
Sequence	>7CFM_nogp_Chain_R L S L A L A S L I I T A N L L L A L G I A W D R R L R S P P A G C F F L S L L L A G L L T G L A L P T L P G L W N Q S R R G Y W S C L L V Y L A P N F S F L S L L A N L L L V H G E R Y M A V L R P L Q P P G S I R L A L L L T W A G P L L F A S L P A L G W N H W T P G A N C S S Q A I F P A P Y L Y L E V Y G L L L P A V G A A A F L S V R V L A T A H R Q L Q D I C R L E R A V C R D E P S A L A R A L T W R Q A R A Q A G A M L L F G L C W G P Y V A T L L L S V L A Y E Q R P P L G P G T L L S L L S L G S A S A A A V P V A M G L G D Q R Y T A P W R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9GYO	A	Steroid	Bile acid	GPBA	Homo sapiens	P395	-	chim(NtGi1-Gs)/β1/γ2	2.5	2024-10-09	To be published
	9GYO (No Gprot)	A	Steroid	Bile acid	GPBA	Homo sapiens	P395	-		2.5	2024-10-09	To be published
	7XTQ	A	Steroid	Bile Acid	GPBA	Homo sapiens	R399	-	Gs/β1/γ2	3.2	2022-07-06	10.1073/pnas.2117054119
	7XTQ (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	R399	-		3.2	2022-07-06	10.1073/pnas.2117054119
	7CFN	A	Steroid	Bile Acid	GPBA	Homo sapiens	INT-777	-	Gs/β1/γ2	3	2020-09-09	10.1038/s41586-020-2569-1
	7CFN (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	INT-777	-		3	2020-09-09	10.1038/s41586-020-2569-1
	7CFM	A	Steroid	Bile Acid	GPBA	Homo sapiens	P395	-	Gs/β1/γ2	3	2020-09-09	10.1038/s41586-020-2569-1
	7CFM (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	P395	-		3	2020-09-09	10.1038/s41586-020-2569-1
	7BW0	A	Steroid	Bile Acid	GPBA	Homo sapiens	-	-	chim(NtGi1-Gs)/β1/γ2	3.9	2020-09-02	10.1038/s41392-020-00262-z
	7BW0 (No Gprot)	A	Steroid	Bile Acid	GPBA	Homo sapiens	-	-		3.9	2020-09-02	10.1038/s41392-020-00262-z

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