Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1R:R:I28 2.3075438
2R:R:N32 5.2825409
3R:R:G61 1.875409
4R:R:G65 2.205439
5R:R:L68 4.61406
6R:R:C85 4.215429
7R:R:Y89 2.2275405
8R:R:S95 2.8275455
9R:R:N102 5.1425418
10R:R:H107 4.62509
11R:R:Q119 3.7225475
12R:R:P135 3.025408
13R:R:L184 3.1075407
14R:R:R216 3.3175403
15R:R:F233 4.8925409
16R:R:W237 6.936508
17R:R:Y240 7.688567
18R:R:P255 2.9404
19R:R:P277 2.62409
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1R:R:S78 R:R:Y89 10.74161.27NoYes035
2R:R:S156 R:R:S78 10.81553.26NoNo043
3R:R:N154 R:R:S156 10.84011.49NoNo034
4R:R:N154 R:R:R79 10.74163.62NoNo033
5R:R:Q77 R:R:R79 10.618416.35NoNo043
6R:R:L263 R:R:S264 15.12691.5NoNo055
7R:R:L265 R:R:S264 18.00946.01NoNo075
8R:R:L265 R:R:L268 23.62652.77NoNo078
9R:R:G269 R:R:L268 36.80713.42NoNo098
10R:R:G269 R:R:S272 25.40031.86NoNo099
11R:R:C236 R:R:S272 27.49453.44NoNo089
12R:R:C236 R:R:V276 29.78571.71NoNo089
13R:R:P277 R:R:V276 1003.53YesNo099
14R:R:G61 R:R:P277 84.23262.03YesYes099
15R:R:G61 R:R:T64 67.15941.82YesNo098
16R:R:G65 R:R:T64 48.75591.82YesNo098
17R:R:G65 R:R:L68 34.26951.71YesYes096
18R:R:L68 R:R:P69 18.00946.57YesNo069
19R:R:L22 R:R:P69 12.19513.28NoNo039
20R:R:G61 R:R:N32 26.36121.7YesYes099
21R:R:L58 R:R:N32 15.12695.49NoYes099
22R:R:L57 R:R:P277 72.4073.28NoYes099
23R:R:L57 R:R:N102 70.70715.49NoYes098
24R:R:L105 R:R:N102 61.46832.75NoYes068
25R:R:F53 R:R:L105 18.009410.96NoNo086
26R:R:E109 R:R:F53 15.12697NoNo098
27R:R:S95 R:R:T64 23.62656.4YesNo058
28R:R:P92 R:R:S95 15.12691.78NoYes065
29R:R:T243 R:R:Y240 15.8662.5NoYes657
30R:R:G269 R:R:T243 14.36311.82NoNo095
31R:R:A101 R:R:P135 41.73441.87NoYes058
32R:R:A101 R:R:T131 44.12421.68NoNo056
33R:R:L105 R:R:T131 46.46465.9NoNo066
34R:R:L97 R:R:P135 28.57853.28NoYes078
35R:R:F138 R:R:L97 25.94233.65NoNo057
36R:R:W237 R:R:Y240 29.95815.79YesYes087
37R:R:L100 R:R:W237 15.12693.42NoYes088
38R:R:H107 R:R:L103 59.47286.43YesNo099
39R:R:L103 R:R:W237 61.46833.42NoYes098
40R:R:H107 R:R:L184 50.99781.29YesYes097
41R:R:L184 R:R:Y111 41.73448.21YesNo079
42R:R:L115 R:R:Y111 20.842611.72NoNo069
43R:R:V188 R:R:Y111 20.84262.52NoNo099
44R:R:L115 R:R:T191 15.12697.37NoNo066
45R:R:F138 R:R:L141 23.62652.44NoNo055
46R:R:L90 R:R:P142 12.19511.64NoNo058
47R:R:L141 R:R:P142 20.84261.64NoNo058
48R:R:F233 R:R:W237 12.195111.02YesYes098
49R:R:L189 R:R:V188 18.00941.49NoNo079
50R:R:L189 R:R:Q226 15.12697.99NoNo077
51R:R:R194 R:R:T191 12.19512.59NoNo056
52R:R:L268 R:R:P239 12.19511.64NoNo089
53R:R:V276 R:R:W237 73.515611.03NoYes098
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7BW0_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.
Net Summary
Imin 1.7
Number of Linked Nodes 241
Number of Links 239
Number of Hubs 19
Number of Links mediated by Hubs 72
Number of Communities 7
Number of Nodes involved in Communities 23
Number of Links involved in Communities 25
Path Summary
Number Of Nodes in MetaPath 54
Number Of Links MetaPath 53
Number of Shortest Paths 9053
Length Of Smallest Path 3
Average Path Length 10.6473
Length of Longest Path 26
Minimum Path Strength 1.085
Average Path Strength 4.06361
Maximum Path Strength 13.74
Minimum Path Correlation 0.7
Average Path Correlation 0.950016
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 6.25
Average % Of Corr. Nodes 75.6601
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 32.5672
Maximum Path Hubs % 100
AnnotationTypeLinks
Gene OntologyMolecular Function
Gene OntologyBiological Process
Gene OntologyCellular Component
SCOP2Domain Identifier• Transducin (heterotrimeric G protein), gamma chain
SCOP2Family Identifier• Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations-• Orientations of Proteins in Membranes database (OPM)   • Protein Data Bank of Transmembrane Proteins (PDBTM)   • MemProtMD


Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainR
ProteinReceptor
UniProtQ8TDU6
Sequence
>7BW0_nogp_Chain_R
PSPIPKGAL GLSLALASL IITANLLLA LGIAWDRRL RSPPAGCFF 
LSLLLAGLL TGLALPTLP GLWNQSRRG YWSCLLVYL APNFSFLSL 
LANLLLVHG ERYMAVLRP LQPPGSIRL ALLLTWAGP LLFASLPAL 
GWNHWTPGA NCSSPYLYL EVYGLLLPA VGAAAFLSV RVLATAHRQ 
LQDICRLER AVCRDEPSA LARALTWRQ ARAQAGAML LFGLCWGPY 
VATLLLSVL AYEQRPPLG PGTLLSLLS LGSASAAAV PVAMGLGDQ 
RYTAPWRAA A


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
7BW0ASteroidBile AcidGPBAHomo sapiens--chim(NtGi1-Gs)/β1/γ23.92020-09-02doi.org/10.1038/s41392-020-00262-z
7BW0 (No Gprot) ASteroidBile AcidGPBAHomo sapiens--3.92020-09-02doi.org/10.1038/s41392-020-00262-z
7CFMASteroidBile AcidGPBAHomo sapiensP395-Gs/β1/γ232020-09-09doi.org/10.1038/s41586-020-2569-1
7CFM (No Gprot) ASteroidBile AcidGPBAHomo sapiensP395-32020-09-09doi.org/10.1038/s41586-020-2569-1
7CFNASteroidBile AcidGPBAHomo sapiensINT-777-Gs/β1/γ232020-09-09doi.org/10.1038/s41586-020-2569-1
7CFN (No Gprot) ASteroidBile AcidGPBAHomo sapiensINT-777-32020-09-09doi.org/10.1038/s41586-020-2569-1
7XTQASteroidBile AcidGPBAHomo sapiensR399-Gs/β1/γ23.22022-07-06doi.org/10.1073/pnas.2117054119
7XTQ (No Gprot) ASteroidBile AcidGPBAHomo sapiensR399-3.22022-07-06doi.org/10.1073/pnas.2117054119
9GYOASteroidBile acidGPBAHomo sapiensP395-chim(NtGi1-Gs)/β1/γ22.52024-10-09To be published
9GYO (No Gprot) ASteroidBile acidGPBAHomo sapiensP395-2.52024-10-09To be published




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7BW0_nogp.zip



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