psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E278	R:R:Y22	11.22	No	No	0	3	2
2	R:R:I281	R:R:Y22	7.25	No	No	0	2	2
3	R:R:F24	R:R:I28	6.28	No	No	0	2	5
4	R:R:K85	R:R:T29	4.5	No	No	0	5	5
5	R:R:T29	R:R:V285	3.17	No	No	0	5	6
6	R:R:K85	R:R:Y30	8.36	No	No	0	5	5
7	R:R:A288	R:R:V32	3.39	No	No	0	5	5
8	R:R:F33	R:R:L78	6.09	Yes	No	0	7	8
9	R:R:A288	R:R:F33	5.55	No	Yes	0	5	7
10	R:R:F291	R:R:F33	3.22	No	Yes	0	7	7
11	R:R:L39	R:R:V35	2.98	No	No	0	6	5
12	R:R:L78	R:R:T36	2.95	No	No	0	8	7
13	R:R:F292	R:R:T36	6.49	No	No	4	5	7
14	R:R:C295	R:R:T36	5.07	Yes	No	4	8	7
15	R:R:F37	R:R:P79	8.67	No	No	0	7	9
16	R:R:C295	R:R:L39	4.76	Yes	No	0	8	6
17	R:R:G40	R:R:T75	3.64	No	No	0	8	6
18	R:R:C295	R:R:G40	3.92	Yes	No	0	8	8
19	R:R:D71	R:R:N44	4.04	Yes	No	0	9	9
20	R:R:F72	R:R:N44	4.83	No	No	0	7	9
21	R:R:N44	R:R:P298	4.89	No	No	0	9	9
22	R:R:A68	R:R:V47	3.39	No	No	0	8	9
23	R:R:V302	R:R:V47	9.62	No	No	0	7	9
24	R:R:F303	R:R:V47	3.93	No	No	0	7	9
25	R:R:I48	R:R:L65	2.85	No	No	0	7	6
26	R:R:R54	R:R:W49	10	No	No	0	5	4
27	R:R:L312	R:R:V50	4.47	No	No	0	5	7
28	R:R:M55	R:R:T61	3.01	Yes	No	0	5	7
29	R:R:F308	R:R:M55	7.46	No	Yes	0	9	5
30	R:R:M55	R:R:R311	7.44	Yes	No	0	5	5
31	R:R:H57	R:R:I62	3.98	No	No	0	6	6
32	R:R:T58	R:R:V59	3.17	No	No	0	8	7
33	R:R:T58	R:R:T61	6.28	No	No	5	8	7
34	R:R:R137	R:R:V59	7.85	Yes	No	0	6	7
35	R:R:A142	R:R:V59	5.09	No	No	0	7	7
36	R:R:I119	R:R:S63	4.64	No	No	0	9	7
37	R:R:R123	R:R:Y64	5.14	Yes	No	0	9	8
38	R:R:V302	R:R:Y64	5.05	No	No	0	7	8
39	R:R:I146	R:R:N66	8.5	No	No	0	7	9
40	R:R:D71	R:R:L67	4.07	Yes	Yes	2	9	9
41	R:R:L67	R:R:S112	3	Yes	No	2	9	9
42	R:R:I116	R:R:L67	2.85	Yes	Yes	2	8	9
43	R:R:L67	R:R:N297	4.12	Yes	Yes	2	9	9
44	R:R:D71	R:R:S112	7.36	Yes	No	2	9	9
45	R:R:D71	R:R:S294	11.78	Yes	No	0	9	8
46	R:R:D71	R:R:N297	8.08	Yes	Yes	2	9	9
47	R:R:C73	R:R:N108	7.87	No	No	0	7	8
48	R:R:F74	R:R:V105	7.87	Yes	Yes	1	7	6
49	R:R:F74	R:R:L109	12.18	Yes	Yes	1	7	8
50	R:R:F291	R:R:F74	13.93	No	Yes	0	7	7
51	R:R:F74	R:R:S294	6.61	Yes	No	0	7	8
52	R:R:T77	R:R:V101	4.76	No	No	0	7	5
53	R:R:I104	R:R:T77	4.56	No	No	0	5	7
54	R:R:T77	R:R:V105	3.17	No	Yes	0	7	6
55	R:R:F80	R:R:F93	4.29	No	Yes	0	6	7
56	R:R:F80	R:R:V101	6.55	No	No	0	6	5
57	R:R:F81	R:R:R84	3.21	No	No	0	6	5
58	R:R:F81	R:R:V105	7.87	No	Yes	0	6	6
59	R:R:R84	R:R:W91	4	No	Yes	0	5	9
60	R:R:D284	R:R:K85	4.15	No	No	0	5	5
61	R:R:M87	R:R:P92	5.03	No	No	0	4	2
62	R:R:H90	R:R:P92	10.68	No	No	0	4	2
63	R:R:H90	R:R:V174	6.92	No	No	0	4	5
64	R:R:F93	R:R:W91	6.01	Yes	Yes	0	7	9
65	R:R:C98	R:R:W91	6.53	No	Yes	7	9	9
66	R:R:C176	R:R:W91	6.53	No	Yes	7	9	9
67	R:R:F93	R:R:L97	6.09	Yes	No	0	7	6
68	R:R:F96	R:R:W95	3.01	No	Yes	0	1	3
69	R:R:K99	R:R:W95	4.64	No	Yes	0	7	3
70	R:R:T165	R:R:W95	6.06	No	Yes	0	4	3
71	R:R:T166	R:R:W95	3.64	No	Yes	0	5	3
72	R:R:C176	R:R:C98	7.28	No	No	7	9	9
73	R:R:F100	R:R:I104	5.02	No	No	0	5	5
74	R:R:F102	R:R:V164	5.24	No	No	0	6	5
75	R:R:C176	R:R:F102	11.17	No	No	0	9	6
76	R:R:I161	R:R:T103	10.64	No	No	0	5	6
77	R:R:I104	R:R:N108	4.25	No	No	0	5	8
78	R:R:L109	R:R:V105	2.98	Yes	Yes	1	8	6
79	L:L:L2	R:R:V105	2.98	No	Yes	0	0	6
80	R:R:D106	R:R:F110	7.17	Yes	Yes	1	5	7
81	R:R:D106	R:R:T157	8.67	Yes	No	1	5	7
82	R:R:D106	R:R:V160	5.84	Yes	Yes	1	5	4
83	R:R:D106	R:R:R201	3.57	Yes	Yes	1	5	5
84	L:L:?1	R:R:D106	13.54	Yes	Yes	1	0	5
85	R:R:I107	R:R:L154	4.28	No	No	0	5	3
86	R:R:I107	R:R:T157	6.08	No	No	0	5	7
87	R:R:L109	R:R:W254	3.42	Yes	Yes	1	8	9
88	L:L:?1	R:R:L109	5.02	Yes	Yes	1	0	8
89	R:R:F110	R:R:F114	6.43	Yes	No	0	7	6
90	R:R:F110	R:R:L156	6.09	Yes	No	0	7	5
91	L:L:?1	R:R:F110	18.77	Yes	Yes	1	0	7
92	R:R:P213	R:R:V113	3.53	No	No	0	9	8
93	R:R:V113	R:R:W254	3.68	No	Yes	0	8	9
94	R:R:F114	R:R:P149	2.89	No	No	0	6	7
95	R:R:F114	R:R:M152	4.98	No	No	0	6	4
96	R:R:L115	R:R:P149	3.28	No	No	0	8	7
97	R:R:F250	R:R:I116	7.54	No	Yes	0	9	8
98	R:R:I116	R:R:N297	5.66	Yes	Yes	2	8	9
99	R:R:I116	R:R:Y301	6.04	Yes	Yes	2	8	9
100	R:R:I119	R:R:R123	3.76	No	Yes	2	9	9
101	R:R:I119	R:R:Y301	6.04	No	Yes	2	9	9
102	R:R:A120	R:R:V217	3.39	No	No	0	9	8
103	R:R:A120	R:R:S220	3.42	No	No	2	9	8
104	R:R:A120	R:R:Y221	4	No	Yes	2	9	8
105	R:R:D122	R:R:R137	7.15	No	Yes	0	8	6
106	R:R:R123	R:R:Y221	4.12	Yes	Yes	2	9	8
107	R:R:R123	R:R:Y301	6.17	Yes	Yes	2	9	9
108	R:R:C124	R:R:L128	3.17	Yes	No	2	8	8
109	R:R:C124	R:R:S220	3.44	Yes	No	2	8	8
110	R:R:C124	R:R:L223	3.17	Yes	No	2	8	4
111	R:R:C124	R:R:I224	3.27	Yes	Yes	0	8	8
112	R:R:C126	R:R:T133	3.38	No	Yes	6	8	5
113	R:R:C126	R:R:R137	5.57	No	Yes	6	8	6
114	R:R:I224	R:R:V127	6.14	Yes	No	0	8	8
115	R:R:L128	R:R:L223	4.15	No	No	2	8	4
116	R:R:H136	R:R:W132	16.93	No	No	0	4	4
117	R:R:R137	R:R:T133	3.88	Yes	Yes	6	6	5
118	R:R:H136	R:R:N135	6.38	No	No	0	4	4
119	R:R:S140	R:R:T138	4.8	No	No	0	4	6
120	R:R:K143	R:R:V139	3.04	No	No	0	3	3
121	R:R:G148	R:R:P149	4.06	No	No	0	2	7
122	R:R:L156	R:R:M152	4.24	No	No	0	5	4
123	R:R:I208	R:R:L156	2.85	No	No	0	5	5
124	R:R:T157	R:R:V160	3.17	No	Yes	1	7	4
125	R:R:V160	R:R:V164	6.41	Yes	No	0	4	5
126	R:R:I162	R:R:R163	6.26	No	No	0	4	5
127	R:R:F180	R:R:R163	5.34	No	No	0	5	5
128	R:R:F178	R:R:V164	7.87	Yes	No	0	4	5
129	R:R:T166	R:R:V174	4.76	No	No	0	5	5
130	R:R:P168	R:R:V167	3.53	No	No	0	1	1
131	R:R:G169	R:R:K170	3.49	No	No	0	2	1
132	R:R:F178	R:R:F180	11.79	Yes	No	0	4	5
133	R:R:F178	R:R:R201	10.69	Yes	Yes	0	4	5
134	R:R:N179	R:R:P182	3.26	No	No	0	4	4
135	R:R:F180	R:R:M197	14.93	No	No	0	5	2
136	R:R:S181	R:R:W183	12.36	Yes	Yes	3	5	1
137	R:R:S181	R:R:T184	3.2	Yes	No	3	5	2
138	R:R:S181	R:R:V193	3.23	Yes	No	0	5	4
139	R:R:P182	R:R:W183	8.11	No	Yes	0	4	1
140	R:R:T184	R:R:W183	9.7	No	Yes	3	2	1
141	R:R:E189	R:R:T184	7.06	No	No	3	4	2
142	R:R:D186	R:R:P187	6.44	No	No	0	1	4
143	R:R:D186	R:R:K188	15.21	No	No	3	1	4
144	R:R:D186	R:R:E189	11.69	No	No	3	1	4
145	R:R:E189	R:R:K188	8.1	No	No	3	4	4
146	R:R:I191	R:R:L272	2.85	No	No	0	2	1
147	R:R:R269	R:R:V195	9.15	Yes	No	0	1	4
148	R:R:L198	R:R:R201	3.64	No	Yes	0	4	5
149	R:R:I268	R:R:L198	4.28	No	No	0	3	4
150	L:L:F3	R:R:L198	4.87	Yes	No	0	0	4
151	L:L:?1	R:R:R201	12.12	Yes	Yes	1	0	5
152	R:R:I204	R:R:I208	4.42	No	No	0	3	5
153	R:R:R205	R:R:Y257	4.12	Yes	Yes	1	6	7
154	R:R:Q258	R:R:R205	7.01	Yes	Yes	1	8	6
155	R:R:A261	R:R:R205	4.15	No	Yes	0	6	6
156	L:L:?1	R:R:R205	11.02	Yes	Yes	1	0	6
157	L:L:F3	R:R:R205	6.41	Yes	Yes	0	0	6
158	R:R:F206	R:R:F210	8.57	No	No	1	6	8
159	R:R:F206	R:R:Q258	3.51	No	Yes	1	6	8
160	R:R:F206	R:R:L262	9.74	No	No	0	6	6
161	R:R:F210	R:R:M214	3.73	No	No	0	8	6
162	R:R:F210	R:R:Q258	15.23	No	Yes	1	8	8
163	R:R:A212	R:R:P213	3.74	No	No	0	5	9
164	R:R:F250	R:R:M214	4.98	No	No	0	9	6
165	R:R:F251	R:R:M214	6.22	No	No	0	6	6
166	R:R:L223	R:R:V219	2.98	No	No	0	4	5
167	R:R:S220	R:R:Y221	6.36	No	Yes	2	8	8
168	R:R:L243	R:R:Y221	10.55	No	Yes	0	7	8
169	R:R:V246	R:R:Y221	5.05	No	Yes	0	8	8
170	R:R:I224	R:R:L243	2.85	Yes	No	0	8	7
171	R:R:K227	R:R:K230	5.75	No	No	8	5	4
172	R:R:K227	R:R:Q231	4.07	No	No	8	5	5
173	R:R:I228	R:R:P239	3.39	No	Yes	0	8	7
174	R:R:H229	R:R:L240	11.57	No	No	0	4	6
175	R:R:K230	R:R:Q231	9.49	No	No	8	4	5
176	R:R:R241	R:R:S237	3.95	No	No	0	6	5
177	R:R:M304	R:R:R238	6.2	No	No	0	7	7
178	R:R:M304	R:R:V242	4.56	No	No	0	7	8
179	R:R:V246	R:R:Y301	3.79	No	Yes	0	8	9
180	R:R:F250	R:R:W254	3.01	No	Yes	0	9	9
181	R:R:F251	R:R:L252	3.65	No	No	0	6	6
182	R:R:F251	R:R:S255	7.93	No	No	0	6	6
183	R:R:C253	R:R:N293	6.3	No	No	0	8	9
184	R:R:W254	R:R:Y257	2.89	Yes	Yes	1	9	7
185	R:R:Q258	R:R:W254	3.29	Yes	Yes	1	8	9
186	R:R:A290	R:R:W254	5.19	No	Yes	0	8	9
187	R:R:N293	R:R:W254	9.04	No	Yes	0	9	9
188	L:L:?1	R:R:W254	3.1	Yes	Yes	1	0	9
189	R:R:P256	R:R:S255	3.56	No	No	0	9	6
190	R:R:L289	R:R:P256	3.28	No	No	0	7	9
191	R:R:T286	R:R:Y257	7.49	No	Yes	0	7	7
192	L:L:?1	R:R:Y257	4.25	Yes	Yes	1	0	7
193	R:R:T286	R:R:V260	7.93	No	No	0	7	5
194	R:R:L262	R:R:T265	4.42	No	No	0	6	4
195	R:R:R267	R:R:V266	5.23	No	No	0	4	5
196	R:R:E270	R:R:R267	5.82	No	No	0	1	4
197	R:R:I268	R:R:L271	2.85	No	No	0	3	1
198	R:R:E270	R:R:Y276	3.37	No	No	0	1	1
199	R:R:I279	R:R:L271	2.85	No	No	0	5	1
200	R:R:M275	R:R:Y276	5.99	No	No	0	3	1
201	R:R:I279	R:R:Y276	7.25	No	No	0	5	1
202	R:R:E278	R:R:K277	6.75	No	No	0	3	3
203	L:L:F3	R:R:V283	7.87	Yes	No	0	0	5
204	R:R:F291	R:R:S287	3.96	No	No	0	7	6
205	R:R:C295	R:R:F292	5.59	Yes	No	4	8	5
206	R:R:F292	R:R:L296	3.65	No	No	0	5	6
207	R:R:N293	R:R:N297	12.26	No	Yes	0	9	9
208	R:R:F308	R:R:V302	5.24	No	No	0	9	7
209	R:R:Q306	R:R:R309	10.51	No	No	0	5	8
210	R:R:E310	R:R:Q306	14.02	No	No	0	5	5
211	L:L:?1	L:L:L2	3.77	Yes	No	0	0	0
212	R:R:D284	R:R:I281	2.8	No	No	0	5	2
213	R:R:L312	R:R:L46	2.77	No	No	0	5	7
214	L:L:F3	R:R:A264	2.77	Yes	No	0	0	4
215	R:R:H90	R:R:T173	2.74	No	No	0	4	3
216	R:R:M275	R:R:Q273	2.72	No	No	0	3	4
217	R:R:N135	R:R:Q134	2.64	No	No	0	4	5
218	R:R:F72	R:R:V41	2.62	No	No	0	7	6
219	R:R:A70	R:R:W150	2.59	No	No	0	8	9
220	R:R:H129	R:R:L128	2.57	No	No	0	7	8
221	R:R:I191	R:R:R269	2.51	No	Yes	0	2	1
222	R:R:F37	R:R:L78	2.44	No	No	0	7	8
223	R:R:F303	R:R:L312	2.44	No	No	0	7	5
224	R:R:T166	R:R:W91	2.43	No	Yes	0	5	9
225	R:R:T133	R:R:W132	2.43	Yes	No	0	5	4
226	R:R:N192	R:R:R269	2.41	No	Yes	0	3	1
227	R:R:N66	R:R:W150	2.26	No	No	0	9	9
228	R:R:F53	R:R:R54	2.14	No	No	0	5	5
229	R:R:G88	R:R:G89	2.11	No	No	0	2	3
230	R:R:R163	R:R:W183	2	No	Yes	0	5	1
231	R:R:A153	R:R:G111	1.95	No	No	0	8	7
232	R:R:A117	R:R:P213	1.87	No	No	0	7	9
233	R:R:G202	R:R:T265	1.82	No	No	0	5	4
234	R:R:P239	R:R:S236	1.78	Yes	No	0	7	6
235	R:R:G45	R:R:I48	1.76	No	No	0	3	7
236	R:R:G88	R:R:M87	1.75	No	No	0	2	4
237	R:R:G43	R:R:L42	1.71	No	No	0	8	4
238	R:R:G52	R:R:L65	1.71	No	No	0	4	6
239	R:R:C73	R:R:V69	1.71	No	No	0	7	5
240	R:R:A70	R:R:S112	1.71	No	No	0	8	9
241	R:R:A175	R:R:V167	1.7	No	No	0	3	1
242	R:R:A175	R:R:T177	1.68	No	No	0	3	4
243	R:R:L158	R:R:P159	1.64	No	No	0	4	8
244	R:R:L240	R:R:P239	1.64	No	Yes	0	6	7
245	R:R:A153	R:R:I107	1.62	No	No	0	8	5
246	R:R:S255	R:R:V259	1.62	No	No	0	6	6
247	R:R:A34	R:R:M82	1.61	No	No	0	5	7
248	R:R:G52	R:R:H57	1.59	No	No	0	4	6
249	R:R:T103	R:R:V160	1.59	No	Yes	0	6	4
250	R:R:T133	R:R:V125	1.59	Yes	No	0	5	5
251	R:R:T286	R:R:V285	1.59	No	No	0	7	6
252	R:R:A51	R:R:L65	1.58	No	No	0	7	6
253	R:R:A194	R:R:L272	1.58	No	No	0	4	1
254	R:R:A225	R:R:L240	1.58	No	No	0	5	6
255	R:R:A249	R:R:L296	1.58	No	No	0	7	6
256	R:R:A249	R:R:L300	1.58	No	No	0	7	8
257	R:R:T58	R:R:T60	1.57	No	No	5	8	7
258	R:R:T60	R:R:T61	1.57	No	No	5	7	7
259	R:R:T171	R:R:T173	1.57	No	No	0	1	3
260	L:L:?1	R:R:G209	1.55	Yes	No	0	0	6
261	R:R:I216	R:R:S215	1.55	No	No	0	6	3
262	R:R:I28	R:R:V32	1.54	No	No	0	5	5
263	R:R:I48	R:R:V69	1.54	No	No	0	7	5
264	R:R:I263	R:R:V259	1.54	No	No	0	5	6
265	R:R:H129	R:R:P130	1.53	No	No	0	7	8
266	R:R:M87	R:R:V83	1.52	No	No	0	4	4
267	R:R:I268	R:R:T199	1.52	No	No	0	3	3
268	R:R:F53	R:R:G52	1.51	No	No	0	5	4
269	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
270	R:R:L42	R:R:V38	1.49	No	No	0	4	5
271	R:R:L42	R:R:V41	1.49	No	No	0	4	6
272	R:R:L141	R:R:T138	1.47	No	No	0	4	6
273	R:R:I146	R:R:I147	1.47	No	No	0	7	3
274	R:R:I207	R:R:I208	1.47	No	No	0	5	5
275	R:R:I224	R:R:I228	1.47	Yes	No	0	8	8
276	R:R:I228	R:R:I234	1.47	No	No	0	8	4
277	R:R:P239	R:R:R238	1.44	Yes	No	0	7	7
278	R:R:I27	R:R:L23	1.43	No	No	0	6	4
279	R:R:I281	R:R:L25	1.43	No	No	0	2	2
280	R:R:I146	R:R:L118	1.43	No	No	0	7	7
281	R:R:I216	R:R:L121	1.43	No	No	0	6	6
282	R:R:I161	R:R:L158	1.43	No	No	0	5	4
283	R:R:I203	R:R:L262	1.43	No	No	0	5	6
284	R:R:D307	R:R:M55	1.39	No	Yes	0	6	5
285	R:R:D26	R:R:L25	1.36	No	No	0	3	2
286	R:R:A86	R:R:Y30	1.33	No	No	0	4	5
287	R:R:A247	R:R:Y221	1.33	No	Yes	0	8	8
288	R:R:L233	R:R:Q231	1.33	No	No	0	2	5
289	R:R:R190	R:R:S181	1.32	No	Yes	0	3	5
290	R:R:A315	R:R:W49	1.3	No	No	0	5	4
291	R:R:F178	R:R:T177	1.3	Yes	No	0	4	4
292	R:R:F33	R:R:M82	1.24	Yes	No	0	7	7
293	R:R:F245	R:R:L300	1.22	No	No	0	6	8
294	R:R:Q273	R:R:R269	1.17	No	Yes	0	4	1
295	R:R:L141	R:R:W132	1.14	No	No	0	4	4
296	R:R:R238	R:R:R309	1.07	No	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F33	4.025	4	0	7
2	R:R:M55	4.825	4	0	5
3	R:R:L67	3.51	4	2	9
4	R:R:D71	7.066	5	2	9
5	R:R:F74	10.1475	4	1	7
6	R:R:W91	5.1	5	7	9
7	R:R:F93	4.475	4	0	7
8	R:R:W95	4.3375	4	0	3
9	R:R:V105	4.974	5	1	6
10	R:R:D106	7.758	5	1	5
11	R:R:L109	5.9	4	1	8
12	R:R:F110	9.615	4	1	7
13	R:R:I116	5.5225	4	2	8
14	R:R:R123	4.7975	4	2	9
15	R:R:C124	3.2625	4	2	8
16	R:R:T133	2.82	4	6	5
17	R:R:R137	6.1125	4	6	6
18	R:R:V160	4.2525	4	1	4
19	R:R:F178	7.9125	4	0	4
20	R:R:S181	5.0275	4	3	5
21	R:R:W183	8.0425	4	3	1
22	R:R:R201	7.505	4	1	5
23	R:R:R205	6.542	5	1	6
24	R:R:Y221	5.235	6	2	8
25	R:R:I224	3.4325	4	0	8
26	R:R:P239	2.0625	4	0	7
27	R:R:W254	4.2025	8	1	9
28	R:R:Y257	4.6875	4	1	7
29	R:R:Q258	7.26	4	1	8
30	R:R:R269	3.81	4	0	1
31	R:R:C295	4.835	4	4	8
32	R:R:N297	7.53	4	2	9
33	R:R:Y301	5.51	4	2	9
34	L:L:?1	8.12667	9	1	0
35	L:L:F3	5.48	4	0	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:D284	R:R:I281	10.9732	2.8	No	No	0	5	2
2	R:R:D284	R:R:K85	12.7707	4.15	No	No	0	5	5
3	R:R:K85	R:R:T29	18.0002	4.5	No	No	0	5	5
4	R:R:T29	R:R:V285	19.7726	3.17	No	No	0	5	6
5	R:R:T286	R:R:V285	21.5325	1.59	No	No	0	7	6
6	R:R:T286	R:R:Y257	25.0272	7.49	No	Yes	0	7	7
7	R:R:W254	R:R:Y257	16.1316	2.89	Yes	Yes	1	9	7
8	R:R:L109	R:R:W254	37.5847	3.42	Yes	Yes	1	8	9
9	R:R:F74	R:R:L109	26.6031	12.18	Yes	Yes	1	7	8
10	R:R:F291	R:R:F74	44.1267	13.93	No	Yes	0	7	7
11	R:R:F291	R:R:F33	40.4648	3.22	No	Yes	0	7	7
12	L:L:?1	R:R:Y257	11.5375	4.25	Yes	Yes	1	0	7
13	L:L:?1	R:R:L109	24.1828	5.02	Yes	Yes	1	0	8
14	R:R:F33	R:R:L78	27.3848	6.09	Yes	No	0	7	8
15	R:R:L78	R:R:T36	21.6537	2.95	No	No	0	8	7
16	R:R:D71	R:R:N297	19.9398	8.08	Yes	Yes	2	9	9
17	R:R:N293	R:R:N297	12.0349	12.26	No	Yes	0	9	9
18	R:R:N293	R:R:W254	12.6787	9.04	No	Yes	0	9	9
19	R:R:D71	R:R:N44	13.544	4.04	Yes	No	0	9	9
20	R:R:V302	R:R:Y64	35.6074	5.05	No	No	0	7	8
21	R:R:R123	R:R:Y64	36.7402	5.14	Yes	No	0	9	8
22	R:R:R123	R:R:Y301	65.0614	6.17	Yes	Yes	2	9	9
23	R:R:I116	R:R:Y301	100	6.04	Yes	Yes	2	8	9
24	R:R:F250	R:R:I116	77.0755	7.54	No	Yes	0	9	8
25	R:R:F250	R:R:W254	76.4276	3.01	No	Yes	0	9	9
26	R:R:L109	R:R:V105	34.6167	2.98	Yes	Yes	1	8	6
27	R:R:T77	R:R:V105	31.1847	3.17	No	Yes	0	7	6
28	R:R:I104	R:R:T77	25.6877	4.56	No	No	0	5	7
29	R:R:I104	R:R:N108	22.5775	4.25	No	No	0	5	8
30	R:R:C73	R:R:N108	21.0099	7.87	No	No	0	7	8
31	R:R:C73	R:R:V69	19.434	1.71	No	No	0	7	5
32	R:R:I48	R:R:V69	17.8497	1.54	No	No	0	7	5
33	L:L:?1	L:L:L2	11.2574	3.77	Yes	No	0	0	0
34	L:L:L2	R:R:V105	10.7432	2.98	No	Yes	0	0	6
35	R:R:I48	R:R:L65	14.656	2.85	No	No	0	7	6
36	R:R:G52	R:R:L65	11.4288	1.71	No	No	0	4	6
37	R:R:F308	R:R:V302	27.2929	5.24	No	No	0	9	7
38	R:R:F308	R:R:M55	26.1266	7.46	No	Yes	0	9	5
39	R:R:M55	R:R:T61	22.4396	3.01	Yes	No	0	5	7
40	R:R:T58	R:R:T61	19.8353	6.28	No	No	5	8	7
41	R:R:T58	R:R:V59	18.6147	3.17	No	No	0	8	7
42	R:R:R137	R:R:V59	16.0104	7.85	Yes	No	0	6	7
43	R:R:I116	R:R:L67	19.7433	2.85	Yes	Yes	2	8	9
44	R:R:A70	R:R:S112	14.7437	1.71	No	No	0	8	9
45	R:R:A70	R:R:W150	12.3067	2.59	No	No	0	8	9
46	R:R:F74	R:R:S294	28.2209	6.61	Yes	No	0	7	8
47	R:R:F81	R:R:V105	23.6895	7.87	No	Yes	0	6	6
48	R:R:F81	R:R:R84	22.4312	3.21	No	No	0	6	5
49	R:R:R84	R:R:W91	21.3736	4	No	Yes	0	5	9
50	R:R:T166	R:R:W91	20.4205	2.43	No	Yes	0	5	9
51	R:R:T166	R:R:V174	13.3141	4.76	No	No	0	5	5
52	R:R:H90	R:R:V174	11.8677	6.92	No	No	0	4	5
53	L:L:?1	R:R:D106	14.3299	13.54	Yes	Yes	1	0	5
54	R:R:F178	R:R:R201	29.3078	10.69	Yes	Yes	0	4	5
55	L:L:?1	R:R:R201	43.0775	12.12	Yes	Yes	1	0	5
56	L:L:?1	R:R:F110	15.63	18.77	Yes	Yes	1	0	7
57	R:R:R123	R:R:Y221	34.3993	4.12	Yes	Yes	2	9	8
58	R:R:V246	R:R:Y221	31.03	5.05	No	Yes	0	8	8
59	R:R:V246	R:R:Y301	32.0793	3.79	No	Yes	0	8	9
60	R:R:S220	R:R:Y221	17.1181	6.36	No	Yes	2	8	8
61	R:R:C124	R:R:S220	14.9319	3.44	Yes	No	2	8	8
62	R:R:L243	R:R:Y221	38.8931	10.55	No	Yes	0	7	8
63	R:R:I224	R:R:L243	36.6232	2.85	Yes	No	0	8	7
64	R:R:R137	R:R:T133	12.1562	3.88	Yes	Yes	6	6	5
65	R:R:F178	R:R:F180	21.0518	11.79	Yes	No	0	4	5
66	R:R:F180	R:R:R163	18.3095	5.34	No	No	0	5	5
67	R:R:R163	R:R:W183	15.5213	2	No	Yes	0	5	1
68	R:R:I268	R:R:L198	23.3718	4.28	No	No	0	3	4
69	R:R:I268	R:R:L271	20.6463	2.85	No	No	0	3	1
70	R:R:I279	R:R:L271	19.2166	2.85	No	No	0	5	1
71	R:R:I279	R:R:Y276	17.7786	7.25	No	No	0	5	1
72	R:R:M275	R:R:Y276	11.943	5.99	No	No	0	3	1
73	R:R:M275	R:R:Q273	10.4632	2.72	No	No	0	3	4
74	R:R:L198	R:R:R201	22.9705	3.64	No	Yes	0	4	5
75	R:R:Q258	R:R:W254	10.0828	3.29	Yes	Yes	1	8	9
76	R:R:F250	R:R:M214	11.8886	4.98	No	No	0	9	6
77	R:R:I224	R:R:I228	32.351	1.47	Yes	No	0	8	8
78	R:R:I228	R:R:P239	27.4183	3.39	No	Yes	0	8	7
79	R:R:P239	R:R:R238	14.982	1.44	Yes	No	0	7	7
80	R:R:D71	R:R:S294	28.3045	11.78	Yes	No	0	9	8
81	R:R:D71	R:R:L67	12.9797	4.07	Yes	Yes	2	9	9
82	R:R:I116	R:R:N297	13.8032	5.66	Yes	Yes	2	8	9
83	L:L:?1	R:R:W254	43.1151	3.1	Yes	Yes	1	0	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F74	R:R:V105	7.87	1	Yes	Yes	7	6	2	1
R:R:F74	R:R:L109	12.18	1	Yes	Yes	7	8	2	1
R:R:T77	R:R:V105	3.17	0	No	Yes	7	6	2	1
R:R:F81	R:R:V105	7.87	0	No	Yes	6	6	2	1
R:R:L109	R:R:V105	2.98	1	Yes	Yes	8	6	1	1
L:L:L2	R:R:V105	2.98	0	No	Yes	0	6	0	1
R:R:D106	R:R:F110	7.17	1	Yes	Yes	5	7	1	1
R:R:D106	R:R:T157	8.67	1	Yes	No	5	7	1	2
R:R:D106	R:R:V160	5.84	1	Yes	Yes	5	4	1	2
R:R:D106	R:R:R201	3.57	1	Yes	Yes	5	5	1	1
L:L:?1	R:R:D106	13.54	1	Yes	Yes	0	5	0	1
R:R:L109	R:R:W254	3.42	1	Yes	Yes	8	9	1	1
L:L:?1	R:R:L109	5.02	1	Yes	Yes	0	8	0	1
R:R:F110	R:R:F114	6.43	1	Yes	No	7	6	1	2
R:R:F110	R:R:L156	6.09	1	Yes	No	7	5	1	2
L:L:?1	R:R:F110	18.77	1	Yes	Yes	0	7	0	1
R:R:V113	R:R:W254	3.68	0	No	Yes	8	9	2	1
R:R:T157	R:R:V160	3.17	1	No	Yes	7	4	2	2
R:R:F178	R:R:R201	10.69	0	Yes	Yes	4	5	2	1
R:R:L198	R:R:R201	3.64	0	No	Yes	4	5	1	1
R:R:I268	R:R:L198	4.28	0	No	No	3	4	2	1
L:L:F3	R:R:L198	4.87	0	Yes	No	0	4	0	1
L:L:?1	R:R:R201	12.12	1	Yes	Yes	0	5	0	1
R:R:R205	R:R:Y257	4.12	1	Yes	Yes	6	7	1	1
R:R:Q258	R:R:R205	7.01	1	Yes	Yes	8	6	2	1
R:R:A261	R:R:R205	4.15	0	No	Yes	6	6	2	1
L:L:?1	R:R:R205	11.02	1	Yes	Yes	0	6	0	1
L:L:F3	R:R:R205	6.41	0	Yes	Yes	0	6	0	1
R:R:F250	R:R:W254	3.01	0	No	Yes	9	9	2	1
R:R:W254	R:R:Y257	2.89	1	Yes	Yes	9	7	1	1
R:R:Q258	R:R:W254	3.29	1	Yes	Yes	8	9	2	1
R:R:A290	R:R:W254	5.19	0	No	Yes	8	9	2	1
R:R:N293	R:R:W254	9.04	0	No	Yes	9	9	2	1
L:L:?1	R:R:W254	3.1	1	Yes	Yes	0	9	0	1
R:R:T286	R:R:Y257	7.49	0	No	Yes	7	7	2	1
L:L:?1	R:R:Y257	4.25	1	Yes	Yes	0	7	0	1
L:L:F3	R:R:V283	7.87	0	Yes	No	0	5	0	1
L:L:F3	R:R:A264	2.77	0	Yes	No	0	4	0	1
L:L:?1	R:R:G209	1.55	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7EUO_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.85
Number of Linked Nodes	270
Number of Links	296
Number of Hubs	35
Number of Links mediated by Hubs	124
Number of Communities	8
Number of Nodes involved in Communities	50
Number of Links involved in Communities	64

Path Summary
Number Of Nodes in MetaPath	84
Number Of Links MetaPath	83
Number of Shortest Paths	53664
Length Of Smallest Path	3
Average Path Length	13.367
Length of Longest Path	32
Minimum Path Strength	1.255
Average Path Strength	5.48251
Maximum Path Strength	15.445
Minimum Path Correlation	0.7
Average Path Correlation	0.932697
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.57143
Average % Of Corr. Nodes	54.2917
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.6423
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• RAGE receptor binding • protein binding • binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement receptor activity • immune receptor activity • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • G protein-coupled receptor binding • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling • intracellular signal transduction • cell communication • intracellular signaling cassette • cellular process • signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • positive regulation of biological process • positive regulation of response to stimulus • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of response to stimulus • immune system process • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • tertiary granule • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FME
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FME
Name	N-Formylmethionine
Synonyms	Formyl-methionine N-Formylmethionine N-formyl-L-methionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid L-N-Formylmethionine
Identifier
Formula	C6 H11 N O3 S
Molecular Weight	177.221
SMILES
PubChem	439750
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21462
Sequence	>7EUO_nogp_Chain_R Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T H T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G H W P F G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H P V W T Q N H R T V S L A K K V I I G P W V M A L L L T L P V I I R V T T V P G K T G T V A C T F N F S P W T N D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G L I K S S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R I R E L L Q G M Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D F R E R L I H A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T6T	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6T (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-		3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVU	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVU (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7EUO	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7EUO (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7VFX	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y
	7VFX (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y

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