psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:L2	6.28	Yes	No	0	0	0
2	L:L:?1	R:R:D106	8.61	Yes	No	1	0	5
3	L:L:?1	R:R:L109	10.04	Yes	No	0	0	8
4	L:L:?1	R:R:F110	17.67	Yes	Yes	1	0	7
5	L:L:?1	R:R:R201	8.81	Yes	Yes	1	0	5
6	L:L:?1	R:R:R205	16.52	Yes	Yes	1	0	6
7	L:L:?1	R:R:W254	6.2	Yes	Yes	0	0	9
8	L:L:?1	R:R:Y257	9.57	Yes	Yes	0	0	7
9	L:L:L2	R:R:F102	6.09	No	Yes	0	0	6
10	L:L:F3	R:R:R205	5.34	No	Yes	0	0	6
11	L:L:F3	R:R:I268	3.77	No	No	0	0	3
12	R:R:I281	R:R:Y22	3.63	No	No	0	2	2
13	R:R:F24	R:R:I28	12.56	No	No	0	2	5
14	R:R:L25	R:R:V285	4.47	No	No	0	2	6
15	R:R:D26	R:R:Y30	20.69	No	No	0	3	5
16	R:R:F33	R:R:T29	3.89	Yes	No	0	7	5
17	R:R:K85	R:R:Y30	13.14	No	No	0	5	5
18	R:R:F33	R:R:M82	3.73	Yes	No	0	7	7
19	R:R:A288	R:R:F33	4.16	No	Yes	0	5	7
20	R:R:F291	R:R:F33	3.22	Yes	Yes	0	7	7
21	R:R:F292	R:R:T36	6.49	No	Yes	7	5	7
22	R:R:C295	R:R:T36	8.45	Yes	Yes	7	8	7
23	R:R:F37	R:R:V41	3.93	No	No	0	7	6
24	R:R:F37	R:R:P79	7.22	No	No	0	7	9
25	R:R:C295	R:R:L39	4.76	Yes	No	0	8	6
26	R:R:T75	R:R:V41	3.17	No	No	0	6	6
27	R:R:F303	R:R:G43	3.01	No	No	0	7	8
28	R:R:F72	R:R:N44	6.04	No	No	0	7	9
29	R:R:N44	R:R:P298	6.52	No	No	0	9	9
30	R:R:L312	R:R:L46	6.92	No	No	0	5	7
31	R:R:A68	R:R:V47	3.39	No	No	0	8	9
32	R:R:V302	R:R:V47	6.41	No	No	0	7	9
33	R:R:F303	R:R:V47	3.93	No	No	0	7	9
34	R:R:I48	R:R:L65	4.28	No	No	0	7	6
35	R:R:A68	R:R:I48	3.25	No	No	0	8	7
36	R:R:I48	R:R:V69	3.07	No	No	0	7	5
37	R:R:F53	R:R:W49	8.02	No	Yes	0	5	4
38	R:R:R54	R:R:W49	14.99	Yes	Yes	8	5	4
39	R:R:A315	R:R:W49	3.89	No	Yes	8	5	4
40	R:R:L316	R:R:W49	4.56	No	Yes	0	6	4
41	R:R:R54	R:R:V50	3.92	Yes	No	0	5	7
42	R:R:M55	R:R:V50	4.56	No	No	0	5	7
43	R:R:A51	R:R:L65	3.15	No	No	0	7	6
44	R:R:F53	R:R:G52	3.01	No	No	0	5	4
45	R:R:R311	R:R:R54	3.2	No	Yes	0	5	5
46	R:R:A315	R:R:R54	4.15	No	Yes	8	5	5
47	R:R:F308	R:R:M55	7.46	Yes	No	0	9	5
48	R:R:M55	R:R:R311	4.96	No	No	0	5	5
49	R:R:H57	R:R:I62	3.98	No	Yes	0	6	6
50	R:R:T58	R:R:T60	3.14	No	No	0	8	7
51	R:R:T58	R:R:T61	9.42	No	No	0	8	7
52	R:R:R137	R:R:V59	17	Yes	No	0	6	7
53	R:R:A142	R:R:V59	5.09	No	No	0	7	7
54	R:R:T60	R:R:Y64	8.74	No	Yes	0	7	8
55	R:R:A142	R:R:I62	3.25	No	Yes	0	7	6
56	R:R:I62	R:R:K143	7.27	Yes	No	0	6	3
57	R:R:I119	R:R:S63	3.1	No	No	0	9	7
58	R:R:R123	R:R:Y64	4.12	Yes	Yes	2	9	8
59	R:R:V302	R:R:Y64	3.79	No	Yes	2	7	8
60	R:R:F308	R:R:Y64	5.16	Yes	Yes	2	9	8
61	R:R:L115	R:R:N66	9.61	No	No	0	8	9
62	R:R:I146	R:R:N66	5.66	No	No	0	7	9
63	R:R:N66	R:R:W150	13.56	No	No	0	9	9
64	R:R:D71	R:R:L67	4.07	Yes	Yes	2	9	9
65	R:R:I116	R:R:L67	4.28	No	Yes	2	8	9
66	R:R:L67	R:R:N297	4.12	Yes	Yes	2	9	9
67	R:R:D71	R:R:S112	5.89	Yes	No	0	9	9
68	R:R:D71	R:R:S294	7.36	Yes	No	0	9	8
69	R:R:D71	R:R:N297	6.73	Yes	Yes	2	9	9
70	R:R:F72	R:R:T75	5.19	No	No	0	7	6
71	R:R:F72	R:R:S76	7.93	No	No	0	7	5
72	R:R:C73	R:R:N108	4.72	No	No	0	7	8
73	R:R:F74	R:R:V105	5.24	Yes	No	0	7	6
74	R:R:F74	R:R:N108	3.62	Yes	No	0	7	8
75	R:R:F291	R:R:F74	17.15	Yes	Yes	0	7	7
76	R:R:F74	R:R:S294	6.61	Yes	No	0	7	8
77	R:R:I104	R:R:T77	3.04	No	No	0	5	7
78	R:R:T77	R:R:V105	3.17	No	No	0	7	6
79	R:R:L78	R:R:P79	3.28	No	No	0	8	9
80	R:R:F80	R:R:F93	6.43	No	Yes	0	6	7
81	R:R:F80	R:R:V101	6.55	No	No	0	6	5
82	R:R:F81	R:R:R84	4.28	Yes	No	1	6	5
83	R:R:F81	R:R:V101	3.93	Yes	No	0	6	5
84	R:R:F102	R:R:F81	6.43	Yes	Yes	1	6	6
85	R:R:F81	R:R:V105	9.18	Yes	No	0	6	6
86	R:R:F291	R:R:F81	3.22	Yes	Yes	0	7	6
87	R:R:F93	R:R:V83	6.55	Yes	No	0	7	4
88	R:R:R84	R:R:W91	8	No	Yes	1	5	9
89	R:R:F102	R:R:R84	7.48	Yes	No	1	6	5
90	R:R:D284	R:R:K85	6.91	No	No	0	5	5
91	R:R:M87	R:R:P92	5.03	No	No	0	4	2
92	R:R:H90	R:R:P92	4.58	No	No	0	4	2
93	R:R:H90	R:R:T173	5.48	No	Yes	0	4	3
94	R:R:F93	R:R:W91	11.02	Yes	Yes	0	7	9
95	R:R:C98	R:R:W91	7.84	No	Yes	1	9	9
96	R:R:C176	R:R:W91	9.14	Yes	Yes	1	9	9
97	R:R:F93	R:R:P92	4.33	Yes	No	0	7	2
98	R:R:F93	R:R:L97	12.18	Yes	No	0	7	6
99	R:R:T165	R:R:W95	8.49	No	No	0	4	3
100	R:R:C98	R:R:T166	5.07	No	No	1	9	5
101	R:R:C176	R:R:C98	5.46	Yes	No	1	9	9
102	R:R:K99	R:R:V164	7.59	No	Yes	0	7	5
103	R:R:F100	R:R:I104	3.77	No	No	0	5	5
104	R:R:F102	R:R:V164	5.24	Yes	Yes	1	6	5
105	R:R:C176	R:R:F102	5.59	Yes	Yes	1	9	6
106	R:R:I161	R:R:T103	6.08	No	No	0	5	6
107	R:R:D106	R:R:F110	9.55	No	Yes	1	5	7
108	R:R:D106	R:R:T157	13.01	No	Yes	0	5	7
109	R:R:I107	R:R:L154	5.71	No	No	0	5	3
110	R:R:I107	R:R:T157	7.6	No	Yes	0	5	7
111	R:R:F291	R:R:L109	6.09	Yes	No	0	7	8
112	R:R:F110	R:R:L156	6.09	Yes	No	0	7	5
113	R:R:P213	R:R:V113	3.53	Yes	No	0	9	8
114	R:R:V113	R:R:W254	6.13	No	Yes	0	8	9
115	R:R:F114	R:R:P149	4.33	No	No	0	6	7
116	R:R:F114	R:R:M152	3.73	No	No	0	6	4
117	R:R:I116	R:R:N297	5.66	No	Yes	2	8	9
118	R:R:I116	R:R:Y301	10.88	No	Yes	2	8	9
119	R:R:L118	R:R:V145	4.47	No	No	0	7	6
120	R:R:L118	R:R:P149	3.28	No	No	0	7	7
121	R:R:I119	R:R:R123	7.52	No	Yes	2	9	9
122	R:R:I119	R:R:Y301	6.04	No	Yes	2	9	9
123	R:R:A120	R:R:V217	5.09	No	No	0	9	8
124	R:R:A120	R:R:S220	3.42	No	Yes	0	9	8
125	R:R:C126	R:R:D122	3.11	No	No	5	8	8
126	R:R:D122	R:R:R137	13.1	No	Yes	5	8	6
127	R:R:R123	R:R:Y221	7.2	Yes	Yes	0	9	8
128	R:R:R123	R:R:Y301	6.17	Yes	Yes	2	9	9
129	R:R:C124	R:R:L128	3.17	No	Yes	9	8	8
130	R:R:C124	R:R:S220	6.89	No	Yes	0	8	8
131	R:R:C124	R:R:L223	3.17	No	Yes	9	8	4
132	R:R:V125	R:R:W132	6.13	No	Yes	0	5	4
133	R:R:C126	R:R:T133	10.14	No	No	5	8	5
134	R:R:C126	R:R:R137	6.96	No	Yes	5	8	6
135	R:R:I224	R:R:V127	7.68	No	No	0	8	8
136	R:R:K227	R:R:V127	4.55	No	No	0	5	8
137	R:R:H129	R:R:L128	3.86	No	Yes	0	7	8
138	R:R:L128	R:R:L223	4.15	Yes	Yes	9	8	4
139	R:R:K227	R:R:L128	7.05	No	Yes	0	5	8
140	R:R:H136	R:R:W132	14.81	No	Yes	0	4	4
141	R:R:L141	R:R:W132	3.42	No	Yes	0	4	4
142	R:R:R137	R:R:T133	10.35	Yes	No	5	6	5
143	R:R:H136	R:R:N135	6.38	No	No	0	4	4
144	R:R:K143	R:R:V139	3.04	No	No	0	3	3
145	R:R:G148	R:R:P149	4.06	No	No	0	2	7
146	R:R:L156	R:R:M152	5.65	No	No	0	5	4
147	R:R:T157	R:R:V160	4.76	Yes	Yes	0	7	4
148	R:R:I161	R:R:T157	3.04	No	Yes	0	5	7
149	R:R:V160	R:R:V164	3.21	Yes	Yes	1	4	5
150	R:R:F178	R:R:V160	5.24	Yes	Yes	1	4	4
151	R:R:R201	R:R:V160	3.92	Yes	Yes	1	5	4
152	R:R:I162	R:R:R163	7.52	No	Yes	0	4	5
153	R:R:N179	R:R:R163	4.82	No	Yes	0	4	5
154	R:R:F180	R:R:R163	8.55	No	Yes	0	5	5
155	R:R:P182	R:R:R163	10.09	No	Yes	0	4	5
156	R:R:F178	R:R:V164	5.24	Yes	Yes	1	4	5
157	R:R:N179	R:R:T165	5.85	No	No	0	4	4
158	R:R:C176	R:R:T166	8.45	Yes	No	1	9	5
159	R:R:R190	R:R:V167	3.92	No	No	0	3	1
160	R:R:P168	R:R:V174	3.53	No	No	0	1	5
161	R:R:F178	R:R:M197	3.73	Yes	No	0	4	2
162	R:R:F178	R:R:R201	10.69	Yes	Yes	1	4	5
163	R:R:F180	R:R:V193	11.8	No	No	0	5	4
164	R:R:F180	R:R:M197	28.61	No	No	0	5	2
165	R:R:R190	R:R:S181	7.91	No	No	0	3	5
166	R:R:P182	R:R:W183	5.4	No	No	0	4	1
167	R:R:R190	R:R:T184	11.64	No	No	0	3	2
168	R:R:E189	R:R:N185	6.57	No	No	0	4	2
169	R:R:D186	R:R:P187	6.44	No	No	0	1	4
170	R:R:D186	R:R:E189	6.5	No	No	0	1	4
171	R:R:R269	R:R:V195	5.23	No	No	0	1	4
172	R:R:I268	R:R:L198	5.71	No	No	0	3	4
173	R:R:I203	R:R:T199	3.04	No	No	0	5	3
174	R:R:T199	R:R:T265	3.14	No	No	0	3	4
175	R:R:R201	R:R:R205	3.2	Yes	Yes	1	5	6
176	R:R:G202	R:R:R205	6	No	Yes	0	5	6
177	R:R:G202	R:R:T265	3.64	No	No	0	5	4
178	R:R:F206	R:R:F210	3.22	No	Yes	4	6	8
179	R:R:F206	R:R:Q258	4.68	No	Yes	4	6	8
180	R:R:F206	R:R:L262	12.18	No	No	0	6	6
181	R:R:G209	R:R:P213	4.06	No	Yes	0	6	9
182	R:R:F210	R:R:M214	14.93	Yes	No	0	8	6
183	R:R:F210	R:R:F251	4.29	Yes	No	4	8	6
184	R:R:F210	R:R:S255	6.61	Yes	No	4	8	6
185	R:R:F210	R:R:Q258	9.37	Yes	Yes	4	8	8
186	R:R:A212	R:R:P213	3.74	No	Yes	0	5	9
187	R:R:M214	R:R:S215	3.07	No	No	0	6	3
188	R:R:L243	R:R:Y221	8.21	Yes	Yes	0	7	8
189	R:R:V246	R:R:Y221	6.31	Yes	Yes	0	8	8
190	R:R:I228	R:R:I234	8.83	No	No	3	8	4
191	R:R:I228	R:R:P239	3.39	No	Yes	3	8	7
192	R:R:L233	R:R:Q231	3.99	No	No	0	2	5
193	R:R:I234	R:R:P239	10.16	No	Yes	3	4	7
194	R:R:K235	R:R:S236	3.06	No	No	0	6	6
195	R:R:R241	R:R:S237	5.27	No	No	0	6	5
196	R:R:R238	R:R:V242	3.92	Yes	No	3	7	8
197	R:R:M304	R:R:R238	3.72	No	Yes	3	7	7
198	R:R:L240	R:R:L243	5.54	No	Yes	6	6	7
199	R:R:M304	R:R:V242	4.56	No	No	3	7	8
200	R:R:V246	R:R:Y301	8.83	Yes	Yes	0	8	9
201	R:R:F250	R:R:W254	9.02	No	Yes	0	9	9
202	R:R:F251	R:R:S255	13.21	No	No	4	6	6
203	R:R:C253	R:R:N293	9.45	No	Yes	0	8	9
204	R:R:Q258	R:R:W254	3.29	Yes	Yes	0	8	9
205	R:R:A290	R:R:W254	7.78	No	Yes	0	8	9
206	R:R:N293	R:R:W254	9.04	Yes	Yes	0	9	9
207	R:R:P256	R:R:S255	3.56	No	No	0	9	6
208	R:R:Q258	R:R:Y257	3.38	Yes	Yes	0	8	7
209	R:R:T286	R:R:Y257	7.49	No	Yes	0	7	7
210	R:R:A290	R:R:Y257	4	No	Yes	0	8	7
211	R:R:V260	R:R:V283	3.21	Yes	No	0	5	5
212	R:R:T286	R:R:V260	9.52	No	Yes	0	7	5
213	R:R:E270	R:R:R267	4.65	No	No	0	1	4
214	R:R:I268	R:R:L271	4.28	No	No	0	3	1
215	R:R:E270	R:R:Y276	7.86	No	No	0	1	1
216	R:R:M275	R:R:Q273	5.44	No	No	0	3	4
217	R:R:M275	R:R:Y276	4.79	No	No	0	3	1
218	R:R:I279	R:R:Y276	7.25	No	No	0	5	1
219	R:R:C295	R:R:F292	5.59	Yes	No	7	8	5
220	R:R:F292	R:R:L296	4.87	No	No	0	5	6
221	R:R:L296	R:R:N293	4.12	No	Yes	0	6	9
222	R:R:N293	R:R:N297	10.9	Yes	Yes	0	9	9
223	R:R:L300	R:R:M299	7.07	No	No	0	8	7
224	R:R:F308	R:R:V302	7.87	Yes	No	2	9	7
225	R:R:Q306	R:R:R309	4.67	No	No	0	5	8
226	R:R:D307	R:R:F308	5.97	No	Yes	0	6	9
227	R:R:L312	R:R:L316	4.15	No	No	0	5	6
228	R:R:R137	R:R:W132	3	Yes	Yes	0	6	4
229	R:R:L240	R:R:S244	3	No	No	6	6	5
230	R:R:L243	R:R:S244	3	Yes	No	6	7	5
231	R:R:L272	R:R:V195	2.98	No	No	0	1	4
232	R:R:L223	R:R:V219	2.98	Yes	No	0	4	5
233	R:R:L300	R:R:V246	2.98	No	Yes	0	8	8
234	R:R:N135	R:R:V131	2.96	No	No	0	4	6
235	R:R:L78	R:R:T36	2.95	No	Yes	0	8	7
236	R:R:L223	R:R:T226	2.95	Yes	No	0	4	4
237	R:R:I146	R:R:I62	2.94	No	Yes	0	7	6
238	R:R:I207	R:R:I208	2.94	No	No	0	5	5
239	R:R:D284	R:R:S287	2.94	No	No	0	5	6
240	R:R:D284	R:R:T29	2.89	No	No	0	5	5
241	R:R:P239	R:R:R238	2.88	Yes	Yes	3	7	7
242	R:R:I281	R:R:L25	2.85	No	No	0	2	2
243	R:R:I208	R:R:L156	2.85	No	No	0	5	5
244	R:R:I279	R:R:L271	2.85	No	No	0	5	1
245	L:L:F3	R:R:A264	2.77	No	No	0	0	4
246	R:R:L115	R:R:L67	2.77	No	Yes	0	8	9
247	R:R:A153	R:R:F110	2.77	No	Yes	0	8	7
248	R:R:L198	R:R:L272	2.77	No	No	0	4	1
249	R:R:A261	R:R:R205	2.77	No	Yes	0	6	6
250	R:R:A247	R:R:Y221	2.67	No	Yes	0	8	8
251	R:R:R267	R:R:V266	2.62	No	No	0	4	5
252	R:R:A70	R:R:W150	2.59	No	No	0	8	9
253	R:R:V217	R:R:Y221	2.52	No	Yes	0	8	8
254	R:R:N185	R:R:W183	2.26	No	No	0	2	1
255	R:R:G88	R:R:G89	2.11	No	No	0	2	3
256	R:R:G169	R:R:P168	2.03	No	No	0	2	1
257	R:R:C295	R:R:G40	1.96	Yes	No	0	8	8
258	R:R:A225	R:R:G222	1.95	No	No	0	5	4
259	R:R:A117	R:R:P213	1.87	No	Yes	0	7	9
260	R:R:G280	R:R:V283	1.84	No	No	0	4	5
261	R:R:G89	R:R:T173	1.82	No	Yes	0	3	3
262	R:R:G172	R:R:T173	1.82	No	Yes	0	5	3
263	R:R:P182	R:R:S181	1.78	No	No	0	4	5
264	R:R:P239	R:R:S236	1.78	Yes	No	0	7	6
265	R:R:P168	R:R:V167	1.77	No	No	0	1	1
266	R:R:G274	R:R:M275	1.75	No	No	0	1	3
267	R:R:G43	R:R:L42	1.71	No	No	0	8	4
268	R:R:G94	R:R:L97	1.71	No	No	0	8	6
269	R:R:A282	R:R:V260	1.7	No	Yes	0	6	5
270	R:R:A175	R:R:T177	1.68	No	No	0	3	4
271	R:R:D307	R:R:G305	1.68	No	No	0	6	8
272	R:R:L158	R:R:P159	1.64	No	No	0	4	8
273	R:R:L289	R:R:P256	1.64	No	No	0	7	9
274	R:R:A218	R:R:M214	1.61	No	No	0	4	6
275	R:R:S140	R:R:T138	1.6	No	No	0	4	6
276	R:R:V242	R:R:V246	1.6	No	Yes	0	8	8
277	R:R:V259	R:R:V260	1.6	No	Yes	0	6	5
278	R:R:T29	R:R:V285	1.59	No	No	0	5	6
279	R:R:T36	R:R:V32	1.59	Yes	No	0	7	5
280	R:R:T36	R:R:V35	1.59	Yes	No	0	7	5
281	R:R:T138	R:R:V139	1.59	No	No	0	6	3
282	R:R:T286	R:R:V285	1.59	No	No	0	7	6
283	R:R:A194	R:R:L272	1.58	No	No	0	4	1
284	R:R:A225	R:R:L240	1.58	No	No	6	5	6
285	R:R:A225	R:R:L243	1.58	No	Yes	6	5	7
286	R:R:A249	R:R:L296	1.58	No	No	0	7	6
287	R:R:A249	R:R:L300	1.58	No	No	0	7	8
288	R:R:T56	R:R:T58	1.57	No	No	0	7	8
289	R:R:T171	R:R:T173	1.57	No	Yes	0	1	3
290	R:R:I207	R:R:S211	1.55	No	No	0	5	5
291	R:R:I216	R:R:S220	1.55	No	Yes	0	6	8
292	R:R:I28	R:R:V32	1.54	No	No	0	5	5
293	R:R:I147	R:R:V151	1.54	No	No	0	3	4
294	R:R:I191	R:R:V195	1.54	No	No	0	2	4
295	R:R:I263	R:R:V259	1.54	No	No	0	5	6
296	R:R:H129	R:R:P130	1.53	No	No	0	7	8
297	R:R:F110	R:R:G111	1.51	Yes	No	0	7	7
298	R:R:L121	R:R:S220	1.5	No	Yes	0	6	8
299	R:R:I204	R:R:I208	1.47	No	No	0	3	5
300	R:R:I228	R:R:L233	1.43	No	No	0	8	2
301	R:R:D26	R:R:I27	1.4	No	No	0	3	6
302	R:R:D186	R:R:K188	1.38	No	No	0	1	4
303	R:R:F245	R:R:M304	1.24	No	No	0	6	7
304	R:R:F251	R:R:L252	1.22	No	No	0	6	6
305	R:R:Q306	R:R:R238	1.17	No	Yes	0	5	7
306	R:R:E278	R:R:Y22	1.12	No	No	0	3	2
307	R:R:R238	R:R:R241	1.07	Yes	No	0	7	6
308	R:R:F96	R:R:W95	1	No	No	0	1	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.4625	8	1	0
2	R:R:F33	3.75	4	0	7
3	R:R:T36	4.214	5	7	7
4	R:R:W49	7.865	4	8	4
5	R:R:R54	6.565	4	8	5
6	R:R:I62	4.36	4	0	6
7	R:R:Y64	5.4525	4	2	8
8	R:R:L67	3.81	4	2	9
9	R:R:D71	6.0125	4	2	9
10	R:R:F74	8.155	4	0	7
11	R:R:F81	5.408	5	1	6
12	R:R:W91	9	4	1	9
13	R:R:F93	8.102	5	0	7
14	R:R:F102	6.166	5	1	6
15	R:R:F110	7.518	5	1	7
16	R:R:R123	6.2525	4	2	9
17	R:R:L128	4.5575	4	9	8
18	R:R:W132	6.84	4	0	4
19	R:R:R137	10.082	5	5	6
20	R:R:T157	7.1025	4	0	7
21	R:R:V160	4.2825	4	1	4
22	R:R:R163	7.745	4	0	5
23	R:R:V164	5.32	4	1	5
24	R:R:T173	2.6725	4	0	3
25	R:R:C176	7.16	4	1	9
26	R:R:F178	6.225	4	1	4
27	R:R:R201	6.655	4	1	5
28	R:R:R205	6.766	5	1	6
29	R:R:F210	7.684	5	4	8
30	R:R:P213	3.3	4	0	9
31	R:R:S220	3.34	4	0	8
32	R:R:Y221	5.382	5	0	8
33	R:R:L223	3.3125	4	9	4
34	R:R:R238	2.552	5	3	7
35	R:R:P239	4.5525	4	3	7
36	R:R:L243	4.5825	4	6	7
37	R:R:V246	4.93	4	0	8
38	R:R:W254	6.91	6	0	9
39	R:R:Y257	6.11	4	0	7
40	R:R:Q258	5.18	4	4	8
41	R:R:V260	4.0075	4	0	5
42	R:R:F291	7.42	4	0	7
43	R:R:N293	8.3775	4	0	9
44	R:R:C295	5.19	4	7	8
45	R:R:N297	6.8525	4	2	9
46	R:R:Y301	7.98	4	2	9
47	R:R:F308	6.615	4	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	L:L:L2	25.1496	6.28	Yes	No	0	0	0
2	L:L:L2	R:R:F102	24.4495	6.09	No	Yes	0	0	6
3	L:L:?1	R:R:R205	21.7314	16.52	Yes	Yes	1	0	6
4	L:L:F3	R:R:R205	18.2857	5.34	No	Yes	0	0	6
5	L:L:F3	R:R:I268	16.339	3.77	No	No	0	0	3
6	L:L:?1	R:R:Y257	17.8024	9.57	Yes	Yes	0	0	7
7	R:R:T286	R:R:Y257	27.0084	7.49	No	Yes	0	7	7
8	R:R:T286	R:R:V285	13.3628	1.59	No	No	0	7	6
9	L:L:?1	R:R:W254	71.487	6.2	Yes	Yes	0	0	9
10	R:R:N293	R:R:W254	88.5124	9.04	Yes	Yes	0	9	9
11	R:R:L296	R:R:N293	34.5231	4.12	No	Yes	0	6	9
12	R:R:F292	R:R:L296	20.1115	4.87	No	No	0	5	6
13	R:R:F292	R:R:T36	15.6801	6.49	No	Yes	7	5	7
14	R:R:F291	R:R:F33	12.6517	3.22	Yes	Yes	0	7	7
15	R:R:L78	R:R:T36	10.2768	2.95	No	Yes	0	8	7
16	R:R:N293	R:R:N297	62.2838	10.9	Yes	Yes	0	9	9
17	R:R:I116	R:R:N297	71.9455	5.66	No	Yes	2	8	9
18	R:R:I116	R:R:Y301	100	10.88	No	Yes	2	8	9
19	R:R:R123	R:R:Y301	64.1124	6.17	Yes	Yes	2	9	9
20	R:R:R123	R:R:Y64	48.0561	4.12	Yes	Yes	2	9	8
21	R:R:V302	R:R:Y64	13.2036	3.79	No	Yes	2	7	8
22	R:R:V302	R:R:V47	12.4513	6.41	No	No	0	7	9
23	R:R:F308	R:R:Y64	28.8479	5.16	Yes	Yes	2	9	8
24	R:R:F308	R:R:M55	25.674	7.46	Yes	No	0	9	5
25	R:R:M55	R:R:V50	12.1383	4.56	No	No	0	5	7
26	R:R:R54	R:R:V50	10.8012	3.92	Yes	No	0	5	7
27	R:R:R54	R:R:W49	16.2594	14.99	Yes	Yes	8	5	4
28	R:R:M55	R:R:R311	12.2289	4.96	No	No	0	5	5
29	R:R:R311	R:R:R54	10.8863	3.2	No	Yes	0	5	5
30	R:R:L67	R:R:N297	10.8094	4.12	Yes	Yes	2	9	9
31	R:R:L115	R:R:L67	23.1344	2.77	No	Yes	0	8	9
32	R:R:L115	R:R:N66	22.1816	9.61	No	No	0	8	9
33	R:R:I146	R:R:N66	19.2905	5.66	No	No	0	7	9
34	R:R:I146	R:R:I62	18.3104	2.94	No	Yes	0	7	6
35	R:R:A142	R:R:I62	12.3442	3.25	No	Yes	0	7	6
36	R:R:A142	R:R:V59	11.3283	5.09	No	No	0	7	7
37	R:R:R137	R:R:V59	10.307	17	Yes	No	0	6	7
38	R:R:D71	R:R:N297	23.5682	6.73	Yes	Yes	2	9	9
39	R:R:F291	R:R:F74	29.2268	17.15	Yes	Yes	0	7	7
40	R:R:F74	R:R:S294	50.4146	6.61	Yes	No	0	7	8
41	R:R:F81	R:R:V105	22.3244	9.18	Yes	No	0	6	6
42	R:R:F291	R:R:F81	23.8729	3.22	Yes	Yes	0	7	6
43	R:R:F74	R:R:V105	23.5544	5.24	Yes	No	0	7	6
44	R:R:F81	R:R:V101	20.1279	3.93	Yes	No	0	6	5
45	R:R:F80	R:R:V101	18.1813	6.55	No	No	0	6	5
46	R:R:F102	R:R:R84	10.8149	7.48	Yes	No	1	6	5
47	R:R:R84	R:R:W91	27.9392	8	No	Yes	1	5	9
48	R:R:F93	R:R:W91	35.0118	11.02	Yes	Yes	0	7	9
49	R:R:C176	R:R:F102	13.22	5.59	Yes	Yes	1	9	6
50	R:R:C176	R:R:W91	10.1175	9.14	Yes	Yes	1	9	9
51	R:R:F93	R:R:P92	34.3062	4.33	Yes	No	0	7	2
52	R:R:H90	R:R:P92	25.7619	4.58	No	No	0	4	2
53	R:R:H90	R:R:T173	21.4815	5.48	No	Yes	0	4	3
54	L:L:?1	R:R:R201	22.3931	8.81	Yes	Yes	1	0	5
55	R:R:F178	R:R:R201	21.3662	10.69	Yes	Yes	1	4	5
56	R:R:F178	R:R:M197	23.2469	3.73	Yes	No	0	4	2
57	R:R:F180	R:R:M197	22.3079	28.61	No	No	0	5	2
58	R:R:F180	R:R:R163	20.3833	8.55	No	Yes	0	5	5
59	L:L:?1	R:R:F110	14.019	17.67	Yes	Yes	1	0	7
60	R:R:F110	R:R:L156	11.3585	6.09	Yes	No	0	7	5
61	R:R:A249	R:R:L296	25.8635	1.58	No	No	0	7	6
62	R:R:A249	R:R:L300	25.4654	1.58	No	No	0	7	8
63	R:R:L300	R:R:V246	25.0178	2.98	No	Yes	0	8	8
64	R:R:V246	R:R:Y221	37.9084	6.31	Yes	Yes	0	8	8
65	R:R:V217	R:R:Y221	39.8633	2.52	No	Yes	0	8	8
66	R:R:A120	R:R:V217	37.244	5.09	No	No	0	9	8
67	R:R:V246	R:R:Y301	41.2553	8.83	Yes	Yes	0	8	9
68	R:R:R123	R:R:Y221	27.6262	7.2	Yes	Yes	0	9	8
69	R:R:A120	R:R:S220	34.6192	3.42	No	Yes	0	9	8
70	R:R:C124	R:R:S220	26.7119	6.89	No	Yes	0	8	8
71	R:R:C124	R:R:L128	16.0425	3.17	No	Yes	9	8	8
72	R:R:P182	R:R:R163	14.4693	10.09	No	Yes	0	4	5
73	R:R:Q258	R:R:W254	18.6261	3.29	Yes	Yes	0	8	9
74	R:R:Q258	R:R:Y257	12.8274	3.38	Yes	Yes	0	8	7
75	R:R:F210	R:R:Q258	12.2289	9.37	Yes	Yes	4	8	8
76	R:R:L243	R:R:Y221	13.3189	8.21	Yes	Yes	0	7	8
77	R:R:V242	R:R:V246	26.4593	1.6	No	Yes	0	8	8
78	R:R:R238	R:R:V242	21.1548	3.92	Yes	No	3	7	8
79	R:R:P239	R:R:R238	12.4924	2.88	Yes	Yes	3	7	7
80	R:R:T286	R:R:V260	12.7313	9.52	No	Yes	0	7	5
81	R:R:D71	R:R:L67	28.48	4.07	Yes	Yes	2	9	9
82	R:R:D71	R:R:S294	50.5354	7.36	Yes	No	0	9	8
83	R:R:F80	R:R:F93	16.1715	6.43	No	Yes	0	6	7
84	R:R:F81	R:R:R84	19.145	4.28	Yes	No	1	6	5
85	R:R:I116	R:R:L67	28.826	4.28	No	Yes	2	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	8.61	1	Yes	No	0	5	0	1
L:L:?1	R:R:L109	10.04	1	Yes	No	0	8	0	1
L:L:?1	R:R:F110	17.67	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:R201	8.81	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R205	16.52	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W254	6.2	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y257	9.57	1	Yes	Yes	0	7	0	1
L:L:L2	R:R:F102	6.09	0	No	Yes	0	6	0	1
L:L:F3	R:R:R205	5.34	0	No	Yes	0	6	0	1
L:L:F3	R:R:I268	3.77	0	No	No	0	3	0	1
R:R:F81	R:R:R84	4.28	1	Yes	No	6	5	2	2
R:R:F102	R:R:F81	6.43	1	Yes	Yes	6	6	1	2
R:R:F291	R:R:F81	3.22	0	Yes	Yes	7	6	2	2
R:R:F102	R:R:R84	7.48	1	Yes	No	6	5	1	2
R:R:F102	R:R:V164	5.24	1	Yes	Yes	6	5	1	2
R:R:C176	R:R:F102	5.59	1	Yes	Yes	9	6	2	1
R:R:D106	R:R:F110	9.55	1	No	Yes	5	7	1	1
R:R:D106	R:R:T157	13.01	1	No	Yes	5	7	1	2
R:R:F291	R:R:L109	6.09	0	Yes	No	7	8	2	1
R:R:F110	R:R:L156	6.09	1	Yes	No	7	5	1	2
R:R:V113	R:R:W254	6.13	0	No	Yes	8	9	2	1
R:R:T157	R:R:V160	4.76	0	Yes	Yes	7	4	2	2
R:R:V160	R:R:V164	3.21	1	Yes	Yes	4	5	2	2
R:R:F178	R:R:V160	5.24	1	Yes	Yes	4	4	2	2
R:R:R201	R:R:V160	3.92	1	Yes	Yes	5	4	1	2
R:R:F178	R:R:V164	5.24	1	Yes	Yes	4	5	2	2
R:R:F178	R:R:R201	10.69	1	Yes	Yes	4	5	2	1
R:R:I268	R:R:L198	5.71	0	No	No	3	4	1	2
R:R:R201	R:R:R205	3.2	1	Yes	Yes	5	6	1	1
R:R:G202	R:R:R205	6	0	No	Yes	5	6	2	1
R:R:F250	R:R:W254	9.02	0	No	Yes	9	9	2	1
R:R:Q258	R:R:W254	3.29	4	Yes	Yes	8	9	2	1
R:R:A290	R:R:W254	7.78	0	No	Yes	8	9	2	1
R:R:N293	R:R:W254	9.04	0	Yes	Yes	9	9	2	1
R:R:Q258	R:R:Y257	3.38	4	Yes	Yes	8	7	2	1
R:R:T286	R:R:Y257	7.49	0	No	Yes	7	7	2	1
R:R:A290	R:R:Y257	4	0	No	Yes	8	7	2	1
R:R:I268	R:R:L271	4.28	0	No	No	3	1	1	2
L:L:F3	R:R:A264	2.77	0	No	No	0	4	0	1
R:R:A153	R:R:F110	2.77	0	No	Yes	8	7	2	1
R:R:A261	R:R:R205	2.77	0	No	Yes	6	6	2	1
R:R:F110	R:R:G111	1.51	1	Yes	No	7	7	1	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7WVU_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.01
Number of Linked Nodes	277
Number of Links	308
Number of Hubs	47
Number of Links mediated by Hubs	164
Number of Communities	9
Number of Nodes involved in Communities	53
Number of Links involved in Communities	67

Path Summary
Number Of Nodes in MetaPath	86
Number Of Links MetaPath	85
Number of Shortest Paths	79017
Length Of Smallest Path	3
Average Path Length	14.1601
Length of Longest Path	27
Minimum Path Strength	1.12
Average Path Strength	6.37562
Maximum Path Strength	18.58
Minimum Path Correlation	0.7
Average Path Correlation	0.930085
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	47.2175
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.2744
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• RAGE receptor binding • protein binding • binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement receptor activity • immune receptor activity • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • G protein-coupled receptor binding • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling • intracellular signal transduction • cell communication • intracellular signaling cassette • cellular process • signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • positive regulation of biological process • positive regulation of response to stimulus • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of response to stimulus • immune system process • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • tertiary granule • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FME
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FME
Name	N-Formylmethionine
Synonyms	Formyl-methionine N-Formylmethionine N-formyl-L-methionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid L-N-Formylmethionine
Identifier
Formula	C6 H11 N O3 S
Molecular Weight	177.221
SMILES
PubChem	439750
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21462
Sequence	>7WVU_nogp_Chain_R S A G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T H T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G H W P F G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H P V W T Q N H R T V S L A K K V I I G P W V M A L L L T L P V I I R V T T V P G K T G T V A C T F N F S P W T N D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G L I K S S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R I R E L L Q G M Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D F R E R L I H A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T6T	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6T (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-		3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVU	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVU (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7EUO	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7EUO (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7VFX	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y
	7VFX (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y

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