psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:E278	R:R:Y22	12.35	No	No	0	3	2
2	R:R:I281	R:R:L25	2.85	Yes	No	0	2	2
3	R:R:L25	R:R:V285	4.47	No	No	0	2	6
4	R:R:F33	R:R:T29	5.19	Yes	No	0	7	5
5	R:R:T29	R:R:V285	4.76	No	No	0	5	6
6	R:R:K85	R:R:Y30	7.17	No	No	0	5	5
7	R:R:A288	R:R:V32	3.39	No	No	0	5	5
8	R:R:F33	R:R:M82	4.98	Yes	No	0	7	7
9	R:R:A288	R:R:F33	4.16	No	Yes	0	5	7
10	R:R:L78	R:R:T36	2.95	No	No	0	8	7
11	R:R:F292	R:R:T36	7.78	No	No	0	5	7
12	R:R:F37	R:R:L78	6.09	Yes	No	0	7	8
13	R:R:F37	R:R:P79	8.67	Yes	No	0	7	9
14	R:R:C295	R:R:L39	4.76	No	No	0	8	6
15	R:R:C295	R:R:G40	3.92	No	No	0	8	8
16	R:R:F72	R:R:V41	3.93	No	No	0	7	6
17	R:R:T75	R:R:V41	3.17	No	No	0	6	6
18	R:R:D71	R:R:N44	8.08	Yes	No	0	9	9
19	R:R:F72	R:R:N44	4.83	No	No	0	7	9
20	R:R:N44	R:R:P298	11.4	No	No	0	9	9
21	R:R:F72	R:R:G45	3.01	No	No	0	7	3
22	R:R:A68	R:R:V47	3.39	No	No	0	8	9
23	R:R:V302	R:R:V47	6.41	Yes	No	2	7	9
24	R:R:I48	R:R:L65	4.28	No	No	0	7	6
25	R:R:A68	R:R:I48	3.25	No	No	0	8	7
26	R:R:I48	R:R:V69	3.07	No	No	0	7	5
27	R:R:R54	R:R:W49	13	No	Yes	0	5	4
28	R:R:A315	R:R:W49	3.89	No	Yes	0	5	4
29	R:R:M55	R:R:V50	3.04	No	No	0	5	7
30	R:R:G52	R:R:L65	3.42	No	No	0	4	6
31	R:R:F308	R:R:M55	6.22	No	No	0	9	5
32	R:R:M55	R:R:R311	13.65	No	No	0	5	5
33	R:R:T58	R:R:T61	6.28	No	No	0	8	7
34	R:R:R137	R:R:V59	9.15	Yes	No	0	6	7
35	R:R:A142	R:R:V59	5.09	No	No	0	7	7
36	R:R:T60	R:R:Y64	6.24	No	Yes	0	7	8
37	R:R:I146	R:R:I62	2.94	No	No	0	7	6
38	R:R:S63	R:R:Y64	3.82	No	Yes	2	7	8
39	R:R:I119	R:R:S63	6.19	No	No	2	9	7
40	R:R:I119	R:R:Y64	3.63	No	Yes	2	9	8
41	R:R:R123	R:R:Y64	4.12	Yes	Yes	2	9	8
42	R:R:V302	R:R:Y64	3.79	Yes	Yes	2	7	8
43	R:R:L115	R:R:N66	4.12	No	No	0	8	9
44	R:R:I146	R:R:N66	8.5	No	No	0	7	9
45	R:R:N66	R:R:W150	4.52	No	No	0	9	9
46	R:R:D71	R:R:L67	4.07	Yes	Yes	2	9	9
47	R:R:I116	R:R:L67	4.28	Yes	Yes	2	8	9
48	R:R:L67	R:R:N297	6.87	Yes	Yes	2	9	9
49	R:R:L67	R:R:Y301	4.69	Yes	Yes	2	9	9
50	R:R:D71	R:R:S112	5.89	Yes	No	0	9	9
51	R:R:D71	R:R:S294	5.89	Yes	No	0	9	8
52	R:R:D71	R:R:N297	8.08	Yes	Yes	2	9	9
53	R:R:C73	R:R:N108	4.72	No	Yes	0	7	8
54	R:R:F74	R:R:T75	3.89	Yes	No	0	7	6
55	R:R:F74	R:R:V105	3.93	Yes	No	0	7	6
56	R:R:F74	R:R:N108	3.62	Yes	Yes	0	7	8
57	R:R:F74	R:R:L109	8.53	Yes	No	0	7	8
58	R:R:F291	R:R:F74	11.79	No	Yes	0	7	7
59	R:R:F74	R:R:S294	6.61	Yes	No	0	7	8
60	R:R:T77	R:R:V101	3.17	No	No	0	7	5
61	R:R:T77	R:R:V105	3.17	No	No	0	7	6
62	R:R:F80	R:R:W91	4.01	No	Yes	1	6	9
63	R:R:F80	R:R:F93	8.57	No	Yes	1	6	7
64	R:R:F80	R:R:V101	3.93	No	No	0	6	5
65	R:R:F81	R:R:V105	5.24	No	No	0	6	6
66	R:R:R84	R:R:W91	5	No	Yes	0	5	9
67	R:R:D284	R:R:K85	9.68	No	No	0	5	5
68	R:R:M87	R:R:P92	10.06	No	No	0	4	2
69	R:R:H90	R:R:P92	4.58	No	No	0	4	2
70	R:R:H90	R:R:T173	6.85	No	No	0	4	3
71	R:R:H90	R:R:V174	4.15	No	No	0	4	5
72	R:R:F93	R:R:W91	21.05	Yes	Yes	1	7	9
73	R:R:C98	R:R:W91	9.14	No	Yes	1	9	9
74	R:R:C176	R:R:W91	11.75	Yes	Yes	1	9	9
75	R:R:F93	R:R:P92	11.56	Yes	No	0	7	2
76	R:R:F93	R:R:L97	7.31	Yes	No	0	7	6
77	R:R:K99	R:R:W95	10.44	No	No	0	7	3
78	R:R:T165	R:R:W95	7.28	No	No	0	4	3
79	R:R:C98	R:R:F102	5.59	No	Yes	1	9	6
80	R:R:C176	R:R:C98	7.28	Yes	No	1	9	9
81	R:R:I161	R:R:K99	2.91	No	No	0	5	7
82	R:R:F100	R:R:I104	7.54	No	No	0	5	5
83	R:R:F102	R:R:V101	3.93	Yes	No	0	6	5
84	R:R:C176	R:R:F102	4.19	Yes	Yes	1	9	6
85	L:L:L4	R:R:F102	6.09	Yes	Yes	1	0	6
86	R:R:I107	R:R:T103	3.04	Yes	No	0	5	6
87	R:R:T103	R:R:V160	3.17	No	No	0	6	4
88	R:R:I161	R:R:T103	9.12	No	No	0	5	6
89	R:R:I104	R:R:N108	2.83	No	Yes	0	5	8
90	R:R:D106	R:R:F110	7.17	No	Yes	1	5	7
91	R:R:D106	R:R:T157	8.67	No	Yes	0	5	7
92	L:L:?1	R:R:D106	12.31	Yes	No	1	0	5
93	R:R:I107	R:R:N108	2.83	Yes	Yes	0	5	8
94	R:R:I107	R:R:T157	6.08	Yes	Yes	0	5	7
95	L:L:?1	R:R:L109	5.02	Yes	No	0	0	8
96	R:R:F110	R:R:F114	4.29	Yes	Yes	0	7	6
97	R:R:F110	R:R:L156	10.96	Yes	No	0	7	5
98	L:L:?1	R:R:F110	12.15	Yes	Yes	1	0	7
99	R:R:F114	R:R:V113	3.93	Yes	No	0	6	8
100	R:R:V113	R:R:W254	4.9	No	Yes	0	8	9
101	R:R:F114	R:R:P149	2.89	Yes	Yes	0	6	7
102	R:R:F114	R:R:M152	3.73	Yes	No	0	6	4
103	R:R:L115	R:R:P149	4.93	No	Yes	0	8	7
104	R:R:F250	R:R:I116	7.54	No	Yes	0	9	8
105	R:R:I116	R:R:N297	5.66	Yes	Yes	2	8	9
106	R:R:I116	R:R:Y301	6.04	Yes	Yes	2	8	9
107	R:R:A117	R:R:I216	4.87	No	No	0	7	6
108	R:R:L118	R:R:V145	2.98	No	No	0	7	6
109	R:R:I119	R:R:R123	5.01	No	Yes	2	9	9
110	R:R:A120	R:R:V217	3.39	No	No	0	9	8
111	R:R:A120	R:R:S220	3.42	No	No	0	9	8
112	R:R:A120	R:R:Y221	4	No	Yes	0	9	8
113	R:R:I216	R:R:L121	2.85	No	No	0	6	6
114	R:R:C126	R:R:D122	3.11	No	No	3	8	8
115	R:R:D122	R:R:R137	11.91	No	Yes	3	8	6
116	R:R:R123	R:R:Y221	5.14	Yes	Yes	0	9	8
117	R:R:R123	R:R:Y301	4.12	Yes	Yes	2	9	9
118	R:R:C124	R:R:L128	3.17	Yes	No	0	8	8
119	R:R:C124	R:R:S220	6.89	Yes	No	0	8	8
120	R:R:C124	R:R:L223	3.17	Yes	No	0	8	4
121	R:R:C124	R:R:I224	3.27	Yes	No	0	8	8
122	R:R:C126	R:R:T133	3.38	No	No	0	8	5
123	R:R:C126	R:R:R137	6.96	No	Yes	3	8	6
124	R:R:L128	R:R:V127	2.98	No	No	0	8	8
125	R:R:I224	R:R:V127	9.22	No	No	0	8	8
126	R:R:K227	R:R:L128	5.64	No	No	0	5	8
127	R:R:H129	R:R:W132	8.46	No	No	0	7	4
128	R:R:H136	R:R:W132	19.04	No	No	0	4	4
129	R:R:H136	R:R:N135	6.38	No	No	0	4	4
130	R:R:S140	R:R:T138	4.8	No	No	0	4	6
131	R:R:K143	R:R:V139	4.55	No	No	0	3	3
132	R:R:L141	R:R:V145	2.98	No	No	0	4	6
133	R:R:G148	R:R:P149	4.06	No	Yes	0	2	7
134	R:R:T157	R:R:V160	4.76	Yes	No	0	7	4
135	R:R:V160	R:R:V164	4.81	No	No	0	4	5
136	R:R:I162	R:R:R163	7.52	No	No	0	4	5
137	R:R:F180	R:R:R163	4.28	Yes	No	0	5	5
138	R:R:F178	R:R:V164	7.87	Yes	No	1	4	5
139	L:L:L4	R:R:V164	2.98	Yes	No	1	0	5
140	R:R:N179	R:R:T165	4.39	No	No	0	4	4
141	R:R:C176	R:R:T166	3.38	Yes	No	0	9	5
142	R:R:N179	R:R:V167	2.96	No	No	0	4	1
143	R:R:T171	R:R:T173	3.14	No	No	0	1	3
144	L:L:L4	R:R:T177	2.95	Yes	No	0	0	4
145	R:R:F178	R:R:F180	12.86	Yes	Yes	0	4	5
146	R:R:F178	R:R:R201	10.69	Yes	Yes	1	4	5
147	L:L:L4	R:R:F178	3.65	Yes	Yes	1	0	4
148	R:R:N179	R:R:P182	3.26	No	No	0	4	4
149	R:R:F180	R:R:M197	16.17	Yes	No	0	5	2
150	R:R:F180	R:R:L198	3.65	Yes	No	0	5	4
151	R:R:S181	R:R:W183	6.18	No	Yes	0	5	1
152	R:R:R190	R:R:S181	3.95	No	No	0	3	5
153	R:R:S181	R:R:V193	4.85	No	No	0	5	4
154	R:R:P182	R:R:W183	5.4	No	Yes	0	4	1
155	R:R:T184	R:R:W183	7.28	No	Yes	4	2	1
156	R:R:E189	R:R:W183	5.45	No	Yes	4	4	1
157	R:R:D186	R:R:T184	4.34	No	No	0	1	2
158	R:R:E189	R:R:T184	9.88	No	No	4	4	2
159	R:R:D186	R:R:K188	2.77	No	No	0	1	4
160	R:R:E189	R:R:V193	4.28	No	No	0	4	4
161	R:R:I191	R:R:L272	2.85	No	No	0	2	1
162	R:R:I191	R:R:Q273	2.74	No	No	0	2	4
163	R:R:N192	R:R:R269	4.82	No	No	0	3	1
164	R:R:R269	R:R:V195	13.08	No	No	0	1	4
165	R:R:I268	R:R:L198	5.71	No	No	0	3	4
166	R:R:R201	R:R:R205	7.46	Yes	Yes	1	5	6
167	L:L:?1	R:R:R201	12.12	Yes	Yes	1	0	5
168	R:R:G202	R:R:R205	3	No	Yes	0	5	6
169	R:R:G202	R:R:T265	5.46	No	No	0	5	4
170	L:L:?1	R:R:R205	17.63	Yes	Yes	1	0	6
171	L:L:F3	R:R:R205	5.34	No	Yes	0	0	6
172	R:R:F206	R:R:F210	3.22	No	Yes	0	6	8
173	R:R:F206	R:R:L262	8.53	No	No	0	6	6
174	R:R:I207	R:R:I208	4.42	No	No	0	5	5
175	R:R:F210	R:R:M214	4.98	Yes	No	0	8	6
176	R:R:F210	R:R:S255	6.61	Yes	No	0	8	6
177	R:R:F210	R:R:Q258	16.4	Yes	No	0	8	8
178	R:R:F250	R:R:M214	3.73	No	No	0	9	6
179	R:R:F251	R:R:M214	7.46	No	No	0	6	6
180	R:R:L243	R:R:Y221	16.41	No	Yes	0	7	8
181	R:R:V246	R:R:Y221	5.05	No	Yes	0	8	8
182	R:R:I224	R:R:L243	2.85	No	No	0	8	7
183	R:R:K227	R:R:Q231	2.71	No	No	0	5	5
184	R:R:I228	R:R:L233	4.28	No	No	0	8	2
185	R:R:I228	R:R:S236	3.1	No	No	0	8	6
186	R:R:I228	R:R:P239	3.39	No	No	0	8	7
187	R:R:G232	R:R:Q231	4.93	No	No	0	4	5
188	R:R:L233	R:R:Q231	3.99	No	No	0	2	5
189	R:R:R241	R:R:S237	5.27	No	No	0	6	5
190	R:R:P239	R:R:R238	2.88	No	Yes	0	7	7
191	R:R:R238	R:R:R241	4.26	Yes	No	0	7	6
192	R:R:R238	R:R:V242	5.23	Yes	No	0	7	8
193	R:R:F245	R:R:R241	3.21	No	No	0	6	6
194	R:R:V246	R:R:Y301	5.05	No	Yes	0	8	9
195	R:R:A249	R:R:L300	3.15	No	No	0	7	8
196	R:R:F250	R:R:W254	8.02	No	Yes	0	9	9
197	R:R:F251	R:R:S255	14.53	No	No	0	6	6
198	R:R:C253	R:R:N293	9.45	No	No	0	8	9
199	R:R:Q258	R:R:W254	4.38	No	Yes	0	8	9
200	R:R:N293	R:R:W254	11.3	No	Yes	0	9	9
201	R:R:T286	R:R:Y257	7.49	No	Yes	0	7	7
202	R:R:S287	R:R:Y257	6.36	No	Yes	0	6	7
203	R:R:A290	R:R:Y257	4	No	Yes	0	8	7
204	L:L:?1	R:R:Y257	4.25	Yes	Yes	0	0	7
205	R:R:T286	R:R:V260	6.35	No	No	0	7	5
206	R:R:L262	R:R:V266	2.98	No	No	0	6	5
207	L:L:F3	R:R:A264	2.77	No	No	0	0	4
208	R:R:I268	R:R:T265	3.04	No	No	0	3	4
209	R:R:R267	R:R:Y276	6.17	No	No	0	4	1
210	R:R:E270	R:R:M275	2.71	No	No	0	1	3
211	R:R:I279	R:R:L271	2.85	No	No	0	5	1
212	R:R:M275	R:R:Q273	4.08	No	No	0	3	4
213	R:R:I279	R:R:Y276	3.63	No	No	0	5	1
214	R:R:E278	R:R:K277	4.05	No	No	0	3	3
215	R:R:E278	R:R:I281	4.1	No	Yes	0	3	2
216	R:R:D284	R:R:I281	11.2	No	Yes	0	5	2
217	L:L:F3	R:R:V283	3.93	No	No	0	0	5
218	R:R:D284	R:R:V285	2.92	No	No	0	5	6
219	R:R:F291	R:R:S287	3.96	No	No	0	7	6
220	R:R:C295	R:R:F292	4.19	No	No	0	8	5
221	R:R:F292	R:R:L296	13.4	No	No	0	5	6
222	R:R:N293	R:R:N297	10.9	No	Yes	0	9	9
223	R:R:N297	R:R:Y301	3.49	Yes	Yes	2	9	9
224	R:R:M299	R:R:P298	3.35	No	No	0	7	9
225	R:R:F308	R:R:V302	6.55	No	Yes	0	9	7
226	R:R:F303	R:R:L312	8.53	Yes	No	0	7	5
227	R:R:E310	R:R:I313	2.73	No	No	0	5	4
228	L:L:?1	L:L:I2	3.88	Yes	No	0	0	0
229	R:R:A247	R:R:Y221	2.67	No	Yes	0	8	8
230	R:R:F37	R:R:V41	2.62	Yes	No	0	7	6
231	R:R:F303	R:R:V47	2.62	Yes	No	2	7	9
232	R:R:F93	R:R:V83	2.62	Yes	No	0	7	4
233	R:R:R267	R:R:V266	2.62	No	No	0	4	5
234	R:R:F303	R:R:V302	2.62	Yes	Yes	2	7	7
235	R:R:A70	R:R:W150	2.59	No	No	0	8	9
236	R:R:F24	R:R:I28	2.51	No	No	0	2	5
237	R:R:F114	R:R:I208	2.51	Yes	No	0	6	5
238	R:R:F206	R:R:I207	2.51	No	No	0	6	5
239	R:R:V50	R:R:W49	2.45	No	Yes	0	7	4
240	R:R:V125	R:R:W132	2.45	No	No	0	5	4
241	R:R:E270	R:R:R269	2.33	No	No	0	1	1
242	R:R:E270	R:R:Y276	2.24	No	No	0	1	1
243	R:R:F291	R:R:F33	2.14	No	Yes	0	7	7
244	R:R:F303	R:R:R309	2.14	Yes	No	0	7	8
245	R:R:G88	R:R:G89	2.11	No	No	0	2	3
246	R:R:G43	R:R:P298	2.03	No	No	0	8	9
247	R:R:A51	R:R:G52	1.95	No	No	0	7	4
248	R:R:A153	R:R:G111	1.95	No	No	0	8	7
249	R:R:A117	R:R:P213	1.87	No	No	0	7	9
250	R:R:A212	R:R:P213	1.87	No	No	0	5	9
251	R:R:G280	R:R:V283	1.84	No	No	0	4	5
252	R:R:G169	R:R:T173	1.82	No	No	0	2	3
253	R:R:P256	R:R:S255	1.78	No	No	0	9	6
254	R:R:P168	R:R:V167	1.77	No	No	0	1	1
255	R:R:P168	R:R:V174	1.77	No	No	0	1	5
256	R:R:G209	R:R:I208	1.76	No	No	0	6	5
257	R:R:G43	R:R:L42	1.71	No	No	0	8	4
258	R:R:A282	R:R:V260	1.7	No	No	0	6	5
259	R:R:I191	R:R:P187	1.69	No	No	0	2	4
260	R:R:L118	R:R:P149	1.64	No	Yes	0	7	7
261	R:R:L158	R:R:P159	1.64	No	No	0	4	8
262	R:R:L289	R:R:P256	1.64	No	No	0	7	9
263	R:R:S211	R:R:S215	1.63	No	No	0	5	3
264	R:R:A153	R:R:I107	1.62	No	Yes	0	8	5
265	R:R:A196	R:R:M197	1.61	No	No	0	3	2
266	R:R:S76	R:R:T77	1.6	No	No	0	5	7
267	R:R:T36	R:R:V35	1.59	No	No	0	7	5
268	R:R:G52	R:R:H57	1.59	No	No	0	4	6
269	R:R:T133	R:R:V125	1.59	No	No	0	5	5
270	R:R:T199	R:R:V195	1.59	No	No	0	3	4
271	R:R:A194	R:R:L272	1.58	No	No	0	4	1
272	R:R:A225	R:R:L240	1.58	No	No	0	5	6
273	R:R:T58	R:R:T60	1.57	No	No	0	8	7
274	R:R:I216	R:R:S220	1.55	No	No	0	6	8
275	R:R:I62	R:R:V139	1.54	No	No	0	6	3
276	R:R:I147	R:R:V151	1.54	No	No	0	3	4
277	R:R:I204	R:R:V200	1.54	No	No	0	3	3
278	R:R:H129	R:R:P130	1.53	No	No	0	7	8
279	R:R:K144	R:R:S140	1.53	No	No	0	3	4
280	R:R:I28	R:R:T29	1.52	No	No	0	5	5
281	R:R:M197	R:R:V200	1.52	No	No	0	2	3
282	R:R:I203	R:R:T199	1.52	No	No	0	5	3
283	R:R:F93	R:R:G94	1.51	Yes	No	0	7	8
284	R:R:G89	R:R:R84	1.5	No	No	0	3	5
285	R:R:K230	R:R:T226	1.5	No	No	0	4	4
286	R:R:L240	R:R:S236	1.5	No	No	0	6	6
287	R:R:L223	R:R:V219	1.49	No	No	0	4	5
288	R:R:L300	R:R:V246	1.49	No	No	0	8	8
289	R:R:N135	R:R:V131	1.48	No	No	0	4	6
290	R:R:L141	R:R:T138	1.47	No	No	0	4	6
291	R:R:L154	R:R:T157	1.47	No	Yes	0	3	7
292	R:R:I234	R:R:K235	1.45	No	No	0	4	6
293	R:R:P159	R:R:R201	1.44	No	Yes	0	8	5
294	R:R:I27	R:R:L23	1.43	No	No	0	6	4
295	R:R:D26	R:R:I281	1.4	No	Yes	0	3	2
296	R:R:L312	R:R:L46	1.38	No	No	0	5	7
297	R:R:L155	R:R:L158	1.38	No	No	0	3	4
298	R:R:A261	R:R:R205	1.38	No	Yes	0	6	6
299	R:R:D26	R:R:L23	1.36	No	No	0	3	4
300	R:R:F37	R:R:V38	1.31	Yes	No	0	7	5
301	R:R:D307	R:R:E310	1.3	No	No	0	6	5
302	R:R:R137	R:R:T60	1.29	Yes	No	0	6	7
303	R:R:H229	R:R:L240	1.29	No	No	0	4	6
304	R:R:K235	R:R:R238	1.24	No	Yes	0	6	7
305	R:R:M304	R:R:R309	1.24	No	No	0	7	8
306	R:R:F251	R:R:L252	1.22	No	No	0	6	6
307	R:R:D307	R:R:R311	1.19	No	No	0	6	5
308	R:R:Q306	R:R:R238	1.17	No	Yes	0	5	7
309	R:R:Q306	R:R:R309	1.17	No	No	0	5	8
310	R:R:F100	R:R:F96	1.07	No	No	0	5	1
311	R:R:F53	R:R:W49	1	No	Yes	0	5	4

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:F33	4.1175	4	0	7
2	R:R:F37	4.6725	4	0	7
3	R:R:W49	5.085	4	0	4
4	R:R:Y64	4.32	5	2	8
5	R:R:L67	4.9775	4	2	9
6	R:R:D71	6.402	5	2	9
7	R:R:F74	6.395	6	0	7
8	R:R:W91	10.19	5	1	9
9	R:R:F93	8.77	6	1	7
10	R:R:F102	4.95	4	1	6
11	R:R:I107	3.3925	4	0	5
12	R:R:N108	3.5	4	0	8
13	R:R:F110	8.6425	4	1	7
14	R:R:F114	3.47	5	0	6
15	R:R:I116	5.88	4	2	8
16	R:R:R123	4.5975	4	2	9
17	R:R:C124	4.125	4	0	8
18	R:R:R137	7.3275	4	3	6
19	R:R:P149	3.38	4	0	7
20	R:R:T157	5.245	4	0	7
21	R:R:C176	6.65	4	1	9
22	R:R:F178	8.7675	4	1	4
23	R:R:F180	9.24	4	0	5
24	R:R:W183	6.0775	4	4	1
25	R:R:R201	7.9275	4	1	5
26	R:R:R205	6.962	5	1	6
27	R:R:F210	7.8025	4	0	8
28	R:R:Y221	6.654	5	0	8
29	R:R:R238	2.956	5	0	7
30	R:R:W254	7.15	4	0	9
31	R:R:Y257	5.525	4	0	7
32	R:R:I281	4.8875	4	0	2
33	R:R:N297	7	5	2	9
34	R:R:Y301	4.678	5	2	9
35	R:R:V302	4.8425	4	2	7
36	R:R:F303	3.9775	4	2	7
37	L:L:?1	9.62286	7	1	0
38	L:L:L4	3.9175	4	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:I281	R:R:L25	10.1891	2.85	Yes	No	0	2	2
2	R:R:L25	R:R:V285	11.6292	4.47	No	No	0	2	6
3	R:R:D284	R:R:I281	10.2295	11.2	No	Yes	0	5	2
4	R:R:D284	R:R:V285	14.4071	2.92	No	No	0	5	6
5	R:R:T29	R:R:V285	27.4333	4.76	No	No	0	5	6
6	R:R:F33	R:R:T29	31.6082	5.19	Yes	No	0	7	5
7	R:R:F291	R:R:F33	37.0992	2.14	No	Yes	0	7	7
8	R:R:F291	R:R:F74	38.0701	11.79	No	Yes	0	7	7
9	R:R:F37	R:R:V41	15.9578	2.62	Yes	No	0	7	6
10	R:R:F37	R:R:L78	11.6697	6.09	Yes	No	0	7	8
11	R:R:L78	R:R:T36	10.2295	2.95	No	No	0	8	7
12	R:R:F72	R:R:V41	12.6379	3.93	No	No	0	7	6
13	R:R:D71	R:R:S294	100	5.89	Yes	No	0	9	8
14	R:R:F74	R:R:S294	99.4552	6.61	Yes	No	0	7	8
15	R:R:D71	R:R:N44	20.5534	8.08	Yes	No	0	9	9
16	R:R:V302	R:R:Y64	44.7126	3.79	Yes	Yes	2	7	8
17	R:R:R123	R:R:Y64	63.3297	4.12	Yes	Yes	2	9	8
18	R:R:R123	R:R:Y301	97.9746	4.12	Yes	Yes	2	9	9
19	R:R:L67	R:R:Y301	53.1649	4.69	Yes	Yes	2	9	9
20	R:R:D71	R:R:L67	57.3883	4.07	Yes	Yes	2	9	9
21	R:R:N297	R:R:Y301	63.0761	3.49	Yes	Yes	2	9	9
22	R:R:D71	R:R:N297	60.8889	8.08	Yes	Yes	2	9	9
23	R:R:F308	R:R:V302	13.7301	6.55	No	Yes	0	9	7
24	R:R:F308	R:R:M55	12.4815	6.22	No	No	0	9	5
25	R:R:T60	R:R:Y64	20.1111	6.24	No	Yes	0	7	8
26	R:R:R137	R:R:T60	16.4055	1.29	Yes	No	0	6	7
27	R:R:F74	R:R:L109	37.172	8.53	Yes	No	0	7	8
28	L:L:?1	R:R:L109	36.4087	5.02	Yes	No	0	0	8
29	L:L:?1	R:R:F110	21.9127	12.15	Yes	Yes	1	0	7
30	R:R:F110	R:R:F114	30.4647	4.29	Yes	Yes	0	7	6
31	R:R:F114	R:R:P149	23.3016	2.89	Yes	Yes	0	6	7
32	R:R:L115	R:R:P149	11.8854	4.93	No	Yes	0	8	7
33	R:R:L115	R:R:N66	10.4183	4.12	No	No	0	8	9
34	R:R:F291	R:R:S287	10.7905	3.96	No	No	0	7	6
35	R:R:S287	R:R:Y257	10.0272	6.36	No	Yes	0	6	7
36	L:L:?1	R:R:Y257	12.0904	4.25	Yes	Yes	0	0	7
37	R:R:F74	R:R:N108	29.1621	3.62	Yes	Yes	0	7	8
38	R:R:F74	R:R:V105	29.0056	3.93	Yes	No	0	7	6
39	R:R:T77	R:R:V105	26.8454	3.17	No	No	0	7	6
40	R:R:T77	R:R:V101	24.7741	3.17	No	No	0	7	5
41	R:R:F80	R:R:V101	21.2465	3.93	No	No	0	6	5
42	R:R:F80	R:R:F93	16.0927	8.57	No	Yes	1	6	7
43	R:R:F93	R:R:P92	14.79	11.56	Yes	No	0	7	2
44	R:R:H90	R:R:P92	11.2247	4.58	No	No	0	4	2
45	R:R:I107	R:R:N108	24.3076	2.83	Yes	Yes	0	5	8
46	R:R:I107	R:R:T103	21.1279	3.04	Yes	No	0	5	6
47	R:R:I161	R:R:T103	22.711	9.12	No	No	0	5	6
48	R:R:I161	R:R:K99	21.2816	2.91	No	No	0	5	7
49	R:R:K99	R:R:W95	19.8738	10.44	No	No	0	7	3
50	R:R:T165	R:R:W95	18.5064	7.28	No	No	0	4	3
51	L:L:L4	R:R:F102	13.0964	6.09	Yes	Yes	1	0	6
52	L:L:L4	R:R:F178	12.3062	3.65	Yes	Yes	1	0	4
53	R:R:F178	R:R:R201	22.8539	10.69	Yes	Yes	1	4	5
54	L:L:?1	R:R:R201	24.7633	12.12	Yes	Yes	1	0	5
55	R:R:F114	R:R:V113	21.055	3.93	Yes	No	0	6	8
56	R:R:N293	R:R:N297	13.6897	10.9	No	Yes	0	9	9
57	R:R:N293	R:R:W254	12.8914	11.3	No	Yes	0	9	9
58	R:R:F250	R:R:I116	28.1912	7.54	No	Yes	0	9	8
59	R:R:I216	R:R:S220	11.5807	1.55	No	No	0	6	8
60	R:R:A120	R:R:S220	31.2495	3.42	No	No	0	9	8
61	R:R:A120	R:R:Y221	35.6563	4	No	Yes	0	9	8
62	R:R:R123	R:R:Y221	39.254	5.14	Yes	Yes	0	9	8
63	R:R:V246	R:R:Y221	36.2739	5.05	No	Yes	0	8	8
64	R:R:V246	R:R:Y301	38.9655	5.05	No	Yes	0	8	9
65	R:R:C126	R:R:R137	11.524	6.96	No	Yes	3	8	6
66	R:R:C124	R:R:S220	18.1747	6.89	Yes	No	0	8	8
67	R:R:C124	R:R:I224	17.8403	3.27	Yes	No	0	8	8
68	R:R:I224	R:R:L243	33.1212	2.85	No	No	0	8	7
69	R:R:L243	R:R:Y221	35.1897	16.41	No	Yes	0	7	8
70	R:R:C124	R:R:L128	22.5572	3.17	Yes	No	0	8	8
71	R:R:I224	R:R:V127	13.2204	9.22	No	No	0	8	8
72	R:R:L128	R:R:V127	11.1276	2.98	No	No	0	8	8
73	R:R:C126	R:R:T133	10.3104	3.38	No	No	0	8	5
74	R:R:K227	R:R:L128	26.9452	5.64	No	No	0	5	8
75	R:R:F178	R:R:F180	11.7506	12.86	Yes	Yes	0	4	5
76	R:R:N179	R:R:T165	17.1687	4.39	No	No	0	4	4
77	R:R:N179	R:R:P182	14.5069	3.26	No	No	0	4	4
78	R:R:P182	R:R:W183	13.0424	5.4	No	Yes	0	4	1
79	R:R:F114	R:R:I208	17.0204	2.51	Yes	No	0	6	5
80	R:R:I207	R:R:I208	14.345	4.42	No	No	0	5	5
81	R:R:F206	R:R:I207	14.1751	2.51	No	No	0	6	5
82	R:R:F206	R:R:L262	22.3442	8.53	No	No	0	6	6
83	R:R:L262	R:R:V266	21.144	2.98	No	No	0	6	5
84	R:R:R267	R:R:V266	19.9385	2.62	No	No	0	4	5
85	R:R:R267	R:R:Y276	18.7276	6.17	No	No	0	4	1
86	R:R:E270	R:R:Y276	15.0624	2.24	No	No	0	1	1
87	L:L:?1	R:R:R205	11.1842	17.63	Yes	Yes	1	0	6
88	R:R:F250	R:R:M214	18.7357	3.73	No	No	0	9	6
89	R:R:F210	R:R:M214	12.9507	4.98	Yes	No	0	8	6
90	R:R:K227	R:R:Q231	20.3161	2.71	No	No	0	5	5
91	R:R:F303	R:R:V302	21.9046	2.62	Yes	Yes	2	7	7
92	R:R:F303	R:R:R309	19.0836	2.14	Yes	No	0	7	8
93	R:R:Q306	R:R:R309	16.7211	1.17	No	No	0	5	8
94	R:R:Q306	R:R:R238	15.556	1.17	No	Yes	0	5	7
95	R:R:F72	R:R:N44	13.8515	4.83	No	No	0	7	9
96	R:R:V113	R:R:W254	21.2142	4.9	No	Yes	0	8	9
97	R:R:F206	R:R:F210	12.797	3.22	No	Yes	0	6	8
98	R:R:I116	R:R:Y301	20.5291	6.04	Yes	Yes	2	8	9
99	R:R:F250	R:R:W254	10.5801	8.02	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:F74	R:R:L109	8.53	0	Yes	No	7	8	2	1
R:R:C98	R:R:F102	5.59	1	No	Yes	9	6	2	1
R:R:C176	R:R:C98	7.28	1	Yes	No	9	9	2	2
R:R:F102	R:R:V101	3.93	1	Yes	No	6	5	1	2
R:R:C176	R:R:F102	4.19	1	Yes	Yes	9	6	2	1
L:L:L4	R:R:F102	6.09	1	Yes	Yes	0	6	0	1
R:R:D106	R:R:F110	7.17	1	No	Yes	5	7	1	1
R:R:D106	R:R:T157	8.67	1	No	Yes	5	7	1	2
L:L:?1	R:R:D106	12.31	1	Yes	No	0	5	0	1
L:L:?1	R:R:L109	5.02	1	Yes	No	0	8	0	1
R:R:F110	R:R:F114	4.29	1	Yes	Yes	7	6	1	2
R:R:F110	R:R:L156	10.96	1	Yes	No	7	5	1	2
L:L:?1	R:R:F110	12.15	1	Yes	Yes	0	7	0	1
R:R:T157	R:R:V160	4.76	0	Yes	No	7	4	2	2
R:R:V160	R:R:V164	4.81	0	No	No	4	5	2	1
R:R:F178	R:R:V164	7.87	1	Yes	No	4	5	1	1
L:L:L4	R:R:V164	2.98	1	Yes	No	0	5	0	1
L:L:L4	R:R:T177	2.95	1	Yes	No	0	4	0	1
R:R:F178	R:R:F180	12.86	1	Yes	Yes	4	5	1	2
R:R:F178	R:R:R201	10.69	1	Yes	Yes	4	5	1	1
L:L:L4	R:R:F178	3.65	1	Yes	Yes	0	4	0	1
R:R:R201	R:R:R205	7.46	1	Yes	Yes	5	6	1	1
L:L:?1	R:R:R201	12.12	1	Yes	Yes	0	5	0	1
R:R:G202	R:R:R205	3	0	No	Yes	5	6	2	1
L:L:?1	R:R:R205	17.63	1	Yes	Yes	0	6	0	1
L:L:F3	R:R:R205	5.34	0	No	Yes	0	6	0	1
R:R:T286	R:R:Y257	7.49	0	No	Yes	7	7	2	1
R:R:S287	R:R:Y257	6.36	0	No	Yes	6	7	2	1
R:R:A290	R:R:Y257	4	0	No	Yes	8	7	2	1
L:L:?1	R:R:Y257	4.25	1	Yes	Yes	0	7	0	1
L:L:F3	R:R:A264	2.77	0	No	No	0	4	0	1
L:L:F3	R:R:V283	3.93	0	No	No	0	5	0	1
R:R:G280	R:R:V283	1.84	0	No	No	4	5	2	1
R:R:P159	R:R:R201	1.44	0	No	Yes	8	5	2	1
R:R:A261	R:R:R205	1.38	0	No	Yes	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7VFX_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	2.71
Number of Linked Nodes	280
Number of Links	311
Number of Hubs	38
Number of Links mediated by Hubs	138
Number of Communities	4
Number of Nodes involved in Communities	32
Number of Links involved in Communities	43

Path Summary
Number Of Nodes in MetaPath	100
Number Of Links MetaPath	99
Number of Shortest Paths	84849
Length Of Smallest Path	3
Average Path Length	14.5166
Length of Longest Path	30
Minimum Path Strength	1.17
Average Path Strength	5.3524
Maximum Path Strength	16.4
Minimum Path Correlation	0.7
Average Path Correlation	0.9288
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	3.7037
Average % Of Corr. Nodes	46.1514
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	44.4505
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• RAGE receptor binding • protein binding • binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement receptor activity • immune receptor activity • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • G protein-coupled receptor binding • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling • intracellular signal transduction • cell communication • intracellular signaling cassette • cellular process • signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • positive regulation of biological process • positive regulation of response to stimulus • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of response to stimulus • immune system process • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • tertiary granule • cell periphery • plasma membrane • D2 dopamine receptor binding • protein binding • binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to stimulus • regulation of biological process • regulation of cellular process • response to stimulus • signaling • biological regulation • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • cell communication • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • cellular process • signal transduction • response to hormone • response to chemical • response to endogenous stimulus • response to peptide hormone • response to oxygen-containing compound • response to nitrogen compound • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of biological quality • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • response to ketone • response to prostaglandin • response to lipid • response to alcohol • response to prostaglandin E • cellular response to forskolin • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to alcohol • response to forskolin • cellular response to lipid • cellular response to ketone • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • Golgi apparatus • cilium • plasma membrane bounded cell projection • ciliary basal body • cell projection • enzyme binding • GTPase binding • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • cell population proliferation • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to hormone stimulus • small GTPase-mediated signal transduction • Ras protein signal transduction • intracellular signal transduction • intracellular signaling cassette • phospholipase C-activating G protein-coupled receptor signaling pathway • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to monoamine stimulus • synaptic signaling • cellular response to acetylcholine • acetylcholine receptor signaling pathway • postsynaptic signal transduction • G protein-coupled acetylcholine receptor signaling pathway • response to acetylcholine • non-motile cilium • 9+0 non-motile cilium • neuron projection • photoreceptor disc membrane • photoreceptor outer segment • photoreceptor cell cilium • synapse • cell junction • G-protein beta-subunit binding • fibroblast proliferation
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FME
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FME
Name	N-Formylmethionine
Synonyms	Formyl-methionine N-Formylmethionine N-formyl-L-methionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid L-N-Formylmethionine
Identifier
Formula	C6 H11 N O3 S
Molecular Weight	177.221
SMILES
PubChem	439750
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21462
Sequence	>7VFX_nogp_Chain_R Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T H T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G H W P F G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H P V W T Q N H R T V S L A K K V I I G P W V M A L L L T L P V I I R V T T V P G K T G T V A C T F N F S P W T N D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G L I K S S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R I R E L L Q G M Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D F R E R L I H A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T6T	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6T (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-		3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVU	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVU (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7EUO	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7EUO (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7VFX	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y
	7VFX (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y

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