psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	17.23	Yes	Yes	1	0	5
2	L:L:?1	R:R:L109	5.02	Yes	Yes	1	0	8
3	L:L:?1	R:R:F110	22.09	Yes	No	0	0	7
4	L:L:?1	R:R:V113	4.05	Yes	Yes	1	0	8
5	L:L:?1	R:R:R201	13.22	Yes	Yes	1	0	5
6	L:L:?1	R:R:R205	24.23	Yes	Yes	1	0	6
7	L:L:?1	R:R:W254	4.13	Yes	Yes	1	0	9
8	L:L:?1	R:R:Y257	6.38	Yes	Yes	1	0	7
9	L:L:I4	L:L:L2	4.28	No	Yes	0	0	0
10	L:L:L2	R:R:F81	6.09	Yes	No	1	0	6
11	L:L:L2	R:R:V105	4.47	Yes	Yes	1	0	6
12	L:L:L2	R:R:D106	4.07	Yes	Yes	1	0	5
13	L:L:L2	R:R:F291	3.65	Yes	Yes	1	0	7
14	L:L:F3	L:L:I5	10.05	Yes	Yes	0	0	0
15	L:L:F3	R:R:R205	8.55	Yes	Yes	1	0	6
16	L:L:F3	R:R:Y257	5.16	Yes	Yes	1	0	7
17	L:L:I4	R:R:F102	10.05	No	Yes	0	0	6
18	L:L:I4	R:R:F178	8.79	No	Yes	0	0	4
19	L:L:I5	R:R:L198	8.56	Yes	No	0	0	4
20	L:L:I5	R:R:L272	5.71	Yes	No	0	0	1
21	R:R:F24	R:R:I27	5.02	No	No	0	2	6
22	R:R:I281	R:R:L25	9.99	No	No	0	2	2
23	R:R:L25	R:R:V285	10.43	No	No	0	2	6
24	R:R:D26	R:R:Y30	10.34	No	No	2	3	5
25	R:R:D26	R:R:K85	6.91	No	Yes	2	3	5
26	R:R:F33	R:R:T29	3.89	Yes	No	0	7	5
27	R:R:K85	R:R:T29	6.01	Yes	No	0	5	5
28	R:R:K85	R:R:Y30	10.75	Yes	No	2	5	5
29	R:R:A288	R:R:V32	3.39	No	No	0	5	5
30	R:R:F33	R:R:M82	6.22	Yes	No	0	7	7
31	R:R:A288	R:R:F33	6.93	No	Yes	0	5	7
32	R:R:F291	R:R:F33	5.36	Yes	Yes	0	7	7
33	R:R:L39	R:R:V35	4.47	No	No	0	6	5
34	R:R:F292	R:R:T36	5.19	Yes	No	4	5	7
35	R:R:C295	R:R:T36	8.45	No	No	4	8	7
36	R:R:F37	R:R:P79	11.56	No	No	3	7	9
37	R:R:F37	R:R:M82	3.73	No	No	3	7	7
38	R:R:G40	R:R:T75	5.46	No	No	0	8	6
39	R:R:F72	R:R:V41	5.24	Yes	No	0	7	6
40	R:R:G43	R:R:L42	5.13	No	No	0	8	4
41	R:R:G43	R:R:L46	5.13	No	No	0	8	7
42	R:R:D71	R:R:N44	14.81	No	No	1	9	9
43	R:R:F72	R:R:N44	4.83	Yes	No	0	7	9
44	R:R:N44	R:R:P298	14.66	No	No	1	9	9
45	R:R:F303	R:R:L46	6.09	No	No	0	7	7
46	R:R:A68	R:R:V47	3.39	No	No	0	8	9
47	R:R:P298	R:R:V47	3.53	No	No	0	9	9
48	R:R:V302	R:R:V47	8.02	No	No	0	7	9
49	R:R:A68	R:R:I48	3.25	No	No	0	8	7
50	R:R:F72	R:R:I48	5.02	Yes	No	0	7	7
51	R:R:F53	R:R:W49	7.02	No	No	0	5	4
52	R:R:R54	R:R:W49	11	No	No	0	5	4
53	R:R:G52	R:R:L65	5.13	No	No	0	4	6
54	R:R:A315	R:R:R54	4.15	No	No	0	5	5
55	R:R:F308	R:R:M55	8.71	No	No	0	9	5
56	R:R:M55	R:R:R311	3.72	No	No	0	5	5
57	R:R:H57	R:R:I62	3.98	No	No	0	6	6
58	R:R:T58	R:R:T61	4.71	No	No	0	8	7
59	R:R:R137	R:R:V59	13.08	Yes	No	0	6	7
60	R:R:A142	R:R:V59	5.09	No	No	0	7	7
61	R:R:T60	R:R:Y64	6.24	No	Yes	0	7	8
62	R:R:R137	R:R:T60	3.88	Yes	No	0	6	7
63	R:R:F308	R:R:T61	5.19	No	No	0	9	7
64	R:R:A142	R:R:I62	3.25	No	No	0	7	6
65	R:R:I62	R:R:K143	7.27	No	No	0	6	3
66	R:R:I119	R:R:Y64	6.04	Yes	Yes	1	9	8
67	R:R:R123	R:R:Y64	5.14	Yes	Yes	1	9	8
68	R:R:Y301	R:R:Y64	5.96	Yes	Yes	1	9	8
69	R:R:V302	R:R:Y64	5.05	No	Yes	0	7	8
70	R:R:L115	R:R:N66	6.87	No	No	5	8	9
71	R:R:I146	R:R:N66	12.74	No	No	0	7	9
72	R:R:N66	R:R:W150	4.52	No	No	5	9	9
73	R:R:I116	R:R:L67	4.28	Yes	No	1	8	9
74	R:R:L67	R:R:N297	4.12	No	Yes	1	9	9
75	R:R:A70	R:R:W150	3.89	No	No	0	8	9
76	R:R:D71	R:R:N297	4.04	No	Yes	1	9	9
77	R:R:D71	R:R:P298	4.83	No	No	1	9	9
78	R:R:F72	R:R:S76	5.28	Yes	No	0	7	5
79	R:R:C73	R:R:N108	4.72	No	No	0	7	8
80	R:R:F74	R:R:L78	9.74	Yes	No	0	7	8
81	R:R:F74	R:R:V105	3.93	Yes	Yes	1	7	6
82	R:R:F74	R:R:N108	3.62	Yes	No	0	7	8
83	R:R:F74	R:R:L109	12.18	Yes	Yes	1	7	8
84	R:R:F291	R:R:F74	16.08	Yes	Yes	1	7	7
85	R:R:F74	R:R:S294	7.93	Yes	No	0	7	8
86	R:R:T77	R:R:V101	4.76	No	Yes	0	7	5
87	R:R:I104	R:R:T77	4.56	No	No	0	5	7
88	R:R:M82	R:R:P79	3.35	No	No	3	7	9
89	R:R:F80	R:R:W91	6.01	Yes	Yes	1	6	9
90	R:R:F80	R:R:F93	13.93	Yes	Yes	1	6	7
91	R:R:F80	R:R:L97	4.87	Yes	No	1	6	6
92	R:R:F80	R:R:V101	11.8	Yes	Yes	1	6	5
93	R:R:F102	R:R:F81	6.43	Yes	No	1	6	6
94	R:R:F81	R:R:V105	7.87	No	Yes	1	6	6
95	R:R:F102	R:R:R84	8.55	Yes	No	0	6	5
96	R:R:D284	R:R:K85	6.91	No	Yes	0	5	5
97	R:R:H90	R:R:M87	6.57	Yes	Yes	1	4	4
98	R:R:M87	R:R:P92	8.39	Yes	No	1	4	2
99	R:R:H90	R:R:P92	6.1	Yes	No	1	4	2
100	R:R:H90	R:R:T173	5.48	Yes	No	0	4	3
101	R:R:H90	R:R:V174	8.3	Yes	No	0	4	5
102	R:R:F93	R:R:W91	17.04	Yes	Yes	1	7	9
103	R:R:C98	R:R:W91	11.75	No	Yes	1	9	9
104	R:R:V101	R:R:W91	6.13	Yes	Yes	1	5	9
105	R:R:C176	R:R:W91	9.14	No	Yes	1	9	9
106	R:R:F93	R:R:P92	5.78	Yes	No	1	7	2
107	R:R:F93	R:R:L97	8.53	Yes	No	1	7	6
108	R:R:K99	R:R:W95	17.4	No	No	0	7	3
109	R:R:T165	R:R:W95	3.64	No	No	0	4	3
110	R:R:T166	R:R:W95	3.64	No	No	0	5	3
111	R:R:C176	R:R:C98	5.46	No	No	1	9	9
112	R:R:F100	R:R:I104	10.05	No	No	0	5	5
113	R:R:F102	R:R:V101	3.93	Yes	Yes	1	6	5
114	R:R:F102	R:R:V105	3.93	Yes	Yes	1	6	6
115	R:R:I161	R:R:T103	7.6	No	No	0	5	6
116	R:R:I104	R:R:N108	4.25	No	No	0	5	8
117	R:R:D106	R:R:T157	4.34	Yes	No	0	5	7
118	R:R:D106	R:R:V160	4.38	Yes	Yes	1	5	4
119	R:R:D106	R:R:R201	4.76	Yes	Yes	1	5	5
120	R:R:I107	R:R:T157	6.08	No	No	0	5	7
121	R:R:L109	R:R:W254	5.69	Yes	Yes	1	8	9
122	R:R:F291	R:R:L109	7.31	Yes	Yes	1	7	8
123	R:R:F110	R:R:F114	7.5	No	No	0	7	6
124	R:R:F110	R:R:L156	7.31	No	No	0	7	5
125	R:R:S112	R:R:S294	3.26	No	No	0	9	8
126	R:R:P213	R:R:V113	3.53	Yes	Yes	0	9	8
127	R:R:F250	R:R:V113	3.93	Yes	Yes	1	9	8
128	R:R:V113	R:R:W254	6.13	Yes	Yes	1	8	9
129	R:R:L115	R:R:P149	6.57	No	No	0	8	7
130	R:R:L115	R:R:W150	3.42	No	No	5	8	9
131	R:R:F250	R:R:I116	8.79	Yes	Yes	1	9	8
132	R:R:I116	R:R:N297	5.66	Yes	Yes	1	8	9
133	R:R:I116	R:R:Y301	4.84	Yes	Yes	1	8	9
134	R:R:A117	R:R:I216	4.87	No	No	0	7	6
135	R:R:L118	R:R:V145	4.47	No	No	0	7	6
136	R:R:L118	R:R:P149	4.93	No	No	0	7	7
137	R:R:I119	R:R:R123	6.26	Yes	Yes	1	9	9
138	R:R:I119	R:R:Y301	4.84	Yes	Yes	1	9	9
139	R:R:A120	R:R:V217	3.39	No	No	0	9	8
140	R:R:A120	R:R:S220	3.42	No	No	0	9	8
141	R:R:A120	R:R:Y221	5.34	No	Yes	0	9	8
142	R:R:D122	R:R:R137	11.91	No	Yes	0	8	6
143	R:R:R123	R:R:Y221	9.26	Yes	Yes	1	9	8
144	R:R:R123	R:R:Y301	4.12	Yes	Yes	1	9	9
145	R:R:C124	R:R:S220	5.16	No	No	0	8	8
146	R:R:V125	R:R:W132	3.68	No	No	0	5	4
147	R:R:C126	R:R:T133	5.07	No	No	0	8	5
148	R:R:I224	R:R:V127	7.68	No	No	0	8	8
149	R:R:L128	R:R:L223	6.92	No	No	0	8	4
150	R:R:K227	R:R:L128	4.23	No	No	0	5	8
151	R:R:H129	R:R:W132	7.41	No	No	0	7	4
152	R:R:H136	R:R:W132	14.81	No	No	0	4	4
153	R:R:R137	R:R:T133	10.35	Yes	No	0	6	5
154	R:R:H136	R:R:N135	3.83	No	No	0	4	4
155	R:R:S140	R:R:T138	4.8	No	No	0	4	6
156	R:R:K143	R:R:V139	6.07	No	No	0	3	3
157	R:R:I146	R:R:K143	4.36	No	No	0	7	3
158	R:R:I147	R:R:V151	4.61	No	No	0	3	4
159	R:R:G148	R:R:P149	4.06	No	No	0	2	7
160	R:R:V160	R:R:V164	6.41	Yes	No	0	4	5
161	R:R:R201	R:R:V160	3.92	Yes	Yes	1	5	4
162	R:R:F180	R:R:R163	7.48	Yes	No	0	5	5
163	R:R:F178	R:R:V164	10.49	Yes	No	0	4	5
164	R:R:T166	R:R:V174	4.76	No	No	0	5	5
165	R:R:P168	R:R:V167	3.53	No	No	0	1	1
166	R:R:T177	R:R:V167	4.76	No	No	0	4	1
167	R:R:N179	R:R:V167	4.43	No	No	0	4	1
168	R:R:F178	R:R:F180	13.93	Yes	Yes	0	4	5
169	R:R:F178	R:R:R201	9.62	Yes	Yes	0	4	5
170	R:R:N179	R:R:P182	4.89	No	No	0	4	4
171	R:R:F180	R:R:M197	17.42	Yes	No	0	5	2
172	R:R:F180	R:R:L198	4.87	Yes	No	0	5	4
173	R:R:S181	R:R:T184	6.4	No	No	0	5	2
174	R:R:D186	R:R:E189	7.8	No	No	0	1	4
175	R:R:E189	R:R:N192	6.57	No	No	0	4	3
176	R:R:I191	R:R:R190	5.01	No	No	0	2	3
177	R:R:N192	R:R:R269	3.62	No	No	0	3	1
178	R:R:R269	R:R:V195	5.23	No	Yes	0	1	4
179	R:R:I268	R:R:L198	5.71	No	No	0	3	4
180	R:R:G202	R:R:R205	4.5	No	Yes	0	5	6
181	R:R:G202	R:R:T265	5.46	No	No	0	5	4
182	R:R:I203	R:R:I207	4.42	No	No	0	5	5
183	R:R:I204	R:R:I208	4.42	No	No	6	3	5
184	R:R:R205	R:R:Y257	8.23	Yes	Yes	1	6	7
185	R:R:Q258	R:R:R205	9.35	Yes	Yes	1	8	6
186	R:R:A261	R:R:R205	5.53	No	Yes	0	6	6
187	R:R:F206	R:R:F210	8.57	No	Yes	1	6	8
188	R:R:F206	R:R:Q258	3.51	No	Yes	1	6	8
189	R:R:F206	R:R:L262	10.96	No	No	0	6	6
190	R:R:G209	R:R:P213	4.06	No	Yes	0	6	9
191	R:R:F210	R:R:M214	3.73	Yes	No	0	8	6
192	R:R:F210	R:R:S255	3.96	Yes	Yes	0	8	6
193	R:R:F210	R:R:Q258	17.57	Yes	Yes	1	8	8
194	R:R:A212	R:R:P213	3.74	No	Yes	0	5	9
195	R:R:F250	R:R:M214	6.22	Yes	No	0	9	6
196	R:R:F251	R:R:M214	7.46	No	No	0	6	6
197	R:R:I224	R:R:Y221	3.63	No	Yes	1	8	8
198	R:R:L243	R:R:Y221	8.21	No	Yes	1	7	8
199	R:R:V246	R:R:Y221	6.31	No	Yes	0	8	8
200	R:R:I224	R:R:L243	7.14	No	No	1	8	7
201	R:R:K230	R:R:T226	6.01	No	No	0	4	4
202	R:R:I228	R:R:L233	8.56	No	No	0	8	2
203	R:R:I228	R:R:I234	7.36	No	No	0	8	4
204	R:R:I228	R:R:L240	4.28	No	No	0	8	6
205	R:R:L233	R:R:Q231	5.32	No	No	0	2	5
206	R:R:I234	R:R:P239	5.08	No	No	0	4	7
207	R:R:R241	R:R:S237	3.95	No	No	0	6	5
208	R:R:R238	R:R:V242	6.54	Yes	No	0	7	8
209	R:R:F245	R:R:R241	8.55	No	No	0	6	6
210	R:R:M304	R:R:V242	4.56	No	No	0	7	8
211	R:R:L300	R:R:V246	7.45	Yes	No	0	8	8
212	R:R:V246	R:R:Y301	7.57	No	Yes	0	8	9
213	R:R:F250	R:R:W254	6.01	Yes	Yes	1	9	9
214	R:R:F250	R:R:N293	4.83	Yes	Yes	1	9	9
215	R:R:F251	R:R:S255	13.21	No	Yes	0	6	6
216	R:R:C253	R:R:N293	7.87	No	Yes	0	8	9
217	R:R:Q258	R:R:W254	3.29	Yes	Yes	1	8	9
218	R:R:A290	R:R:W254	7.78	No	Yes	0	8	9
219	R:R:N293	R:R:W254	9.04	Yes	Yes	1	9	9
220	R:R:P256	R:R:S255	3.56	No	Yes	0	9	6
221	R:R:P256	R:R:T286	3.5	No	No	0	9	7
222	R:R:L289	R:R:P256	4.93	No	No	0	7	9
223	R:R:Q258	R:R:Y257	3.38	Yes	Yes	1	8	7
224	R:R:T286	R:R:Y257	3.75	No	Yes	0	7	7
225	R:R:S287	R:R:Y257	3.82	No	Yes	0	6	7
226	R:R:A290	R:R:Y257	4	No	Yes	0	8	7
227	R:R:A282	R:R:V260	3.39	No	No	0	6	5
228	R:R:T286	R:R:V260	7.93	No	No	0	7	5
229	R:R:I263	R:R:I279	4.42	No	Yes	0	5	5
230	R:R:A264	R:R:I279	3.25	No	Yes	0	4	5
231	R:R:E270	R:R:R267	4.65	No	No	0	1	4
232	R:R:I268	R:R:L272	7.14	No	No	0	3	1
233	R:R:I279	R:R:L271	4.28	Yes	No	0	5	1
234	R:R:E278	R:R:Y276	3.37	No	No	0	3	1
235	R:R:I279	R:R:Y276	6.04	Yes	No	0	5	1
236	R:R:F291	R:R:S287	5.28	Yes	No	0	7	6
237	R:R:C295	R:R:F292	4.19	No	Yes	4	8	5
238	R:R:F292	R:R:L296	4.87	Yes	No	0	5	6
239	R:R:L296	R:R:N293	4.12	No	Yes	0	6	9
240	R:R:N293	R:R:N297	12.26	Yes	Yes	1	9	9
241	R:R:F303	R:R:M299	3.73	No	No	0	7	7
242	R:R:F303	R:R:V302	6.55	No	No	0	7	7
243	R:R:E310	R:R:Q306	10.19	No	No	0	5	5
244	R:R:T29	R:R:V285	3.17	No	No	0	5	6
245	R:R:T103	R:R:V160	3.17	No	Yes	0	6	4
246	R:R:C124	R:R:L128	3.17	No	No	0	8	8
247	R:R:A51	R:R:L65	3.15	No	No	0	7	6
248	R:R:T171	R:R:T173	3.14	No	No	0	1	3
249	R:R:I119	R:R:S63	3.1	Yes	No	0	9	7
250	R:R:F308	R:R:Y64	3.09	No	Yes	0	9	8
251	R:R:R267	R:R:Y276	3.09	No	No	0	4	1
252	R:R:I48	R:R:V69	3.07	No	No	0	7	5
253	R:R:I268	R:R:V195	3.07	No	Yes	0	3	4
254	R:R:K235	R:R:S236	3.06	No	No	0	6	6
255	R:R:H129	R:R:P130	3.05	No	No	0	7	8
256	L:L:I5	R:R:T177	3.04	Yes	No	0	0	4
257	R:R:M87	R:R:V83	3.04	Yes	No	0	4	4
258	R:R:F72	R:R:G45	3.01	Yes	No	0	7	3
259	R:R:G89	R:R:R84	3	No	No	0	3	5
260	R:R:G305	R:R:R309	3	No	No	0	8	8
261	R:R:L312	R:R:V50	2.98	No	No	0	5	7
262	R:R:L141	R:R:V145	2.98	No	No	0	4	6
263	R:R:L223	R:R:V219	2.98	No	No	0	4	5
264	R:R:L78	R:R:T75	2.95	No	No	0	8	6
265	R:R:I204	R:R:I207	2.94	No	No	6	3	5
266	R:R:I207	R:R:I208	2.94	No	No	6	5	5
267	R:R:F178	R:R:P159	2.89	Yes	No	0	4	8
268	R:R:P239	R:R:R238	2.88	No	Yes	0	7	7
269	R:R:I161	R:R:L158	2.85	No	No	0	5	4
270	R:R:L300	R:R:M304	2.83	Yes	No	0	8	7
271	R:R:G94	R:R:W91	2.81	No	Yes	0	8	9
272	L:L:F3	R:R:A264	2.77	Yes	No	0	0	4
273	R:R:L312	R:R:L46	2.77	No	No	0	5	7
274	R:R:H129	R:R:V131	2.77	No	No	0	7	6
275	R:R:A194	R:R:F180	2.77	No	Yes	0	4	5
276	R:R:M275	R:R:Q273	2.72	No	No	0	3	4
277	R:R:E189	R:R:K188	2.7	No	No	0	4	4
278	R:R:A247	R:R:Y221	2.67	No	Yes	0	8	8
279	R:R:N135	R:R:Q134	2.64	No	No	0	4	5
280	R:R:F292	R:R:V35	2.62	Yes	No	0	5	5
281	R:R:H57	R:R:L65	2.57	No	No	0	6	6
282	R:R:F24	R:R:I28	2.51	No	No	0	2	5
283	R:R:F114	R:R:I208	2.51	No	No	0	6	5
284	R:R:F114	R:R:M152	2.49	No	No	0	6	4
285	R:R:V50	R:R:W49	2.45	No	No	0	7	4
286	R:R:Q306	R:R:R309	2.34	No	No	0	5	8
287	R:R:F100	R:R:F96	2.14	No	No	0	5	1
288	R:R:G88	R:R:G89	2.11	No	No	0	2	3
289	R:R:A153	R:R:G111	1.95	No	No	0	8	7
290	R:R:A225	R:R:G222	1.95	No	No	0	5	4
291	R:R:A117	R:R:P213	1.87	No	Yes	0	7	9
292	R:R:G148	R:R:V151	1.84	No	No	0	2	4
293	R:R:G172	R:R:T173	1.82	No	No	0	5	3
294	R:R:P182	R:R:S181	1.78	No	No	0	4	5
295	R:R:K227	R:R:P130	1.67	No	No	0	5	8
296	R:R:A153	R:R:I107	1.62	No	No	0	8	5
297	R:R:S215	R:R:V219	1.62	No	No	0	3	5
298	R:R:S255	R:R:V259	1.62	Yes	No	0	6	6
299	R:R:A86	R:R:M87	1.61	No	Yes	0	4	4
300	R:R:D186	R:R:P187	1.61	No	No	0	1	4
301	R:R:V260	R:R:V283	1.6	No	No	0	5	5
302	R:R:C124	R:R:L121	1.59	No	No	0	8	6
303	R:R:T199	R:R:V195	1.59	No	Yes	0	3	4
304	R:R:T199	R:R:V200	1.59	No	No	0	3	3
305	R:R:T265	R:R:V266	1.59	No	No	0	4	5
306	R:R:A225	R:R:L240	1.58	No	No	0	5	6
307	R:R:A225	R:R:L243	1.58	No	No	0	5	7
308	R:R:A249	R:R:L296	1.58	No	No	0	7	6
309	R:R:A249	R:R:L300	1.58	No	Yes	0	7	8
310	R:R:I28	R:R:V285	1.54	No	No	0	5	6
311	R:R:I191	R:R:V195	1.54	No	Yes	0	2	4
312	R:R:M197	R:R:V193	1.52	No	No	0	2	4
313	R:R:M55	R:R:T56	1.51	No	No	0	5	7
314	R:R:K170	R:R:T171	1.5	No	No	0	1	1
315	R:R:L42	R:R:V38	1.49	No	No	0	4	5
316	R:R:L155	R:R:V151	1.49	No	No	0	3	4
317	R:R:L141	R:R:T138	1.47	No	No	0	4	6
318	R:R:I161	R:R:I162	1.47	No	No	0	5	4
319	R:R:G21	R:R:Y22	1.45	No	No	0	4	2
320	R:R:L154	R:R:L155	1.38	No	No	0	3	3
321	R:R:L154	R:R:L158	1.38	No	No	0	3	4
322	R:R:I191	R:R:Q273	1.37	No	No	0	2	4
323	R:R:R238	R:R:S236	1.32	Yes	No	0	7	6
324	R:R:F245	R:R:S244	1.32	No	No	0	6	5
325	R:R:H229	R:R:L240	1.29	No	No	0	4	6
326	R:R:S181	R:R:W183	1.24	No	No	0	5	1
327	R:R:F245	R:R:L300	1.22	No	Yes	0	6	8
328	R:R:I281	R:R:Y22	1.21	No	No	0	2	2
329	R:R:R238	R:R:R309	1.07	Yes	No	0	7	8

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	12.0437	8	1	0
2	L:L:L2	4.512	5	1	0
3	L:L:F3	6.6325	4	1	0
4	L:L:I5	6.84	4	0	0
5	R:R:F33	5.6	4	0	7
6	R:R:Y64	5.25333	6	1	8
7	R:R:F72	4.676	5	0	7
8	R:R:F74	8.91333	6	1	7
9	R:R:F80	9.1525	4	1	6
10	R:R:K85	7.645	4	2	5
11	R:R:M87	4.9025	4	1	4
12	R:R:H90	6.6125	4	1	4
13	R:R:W91	8.81333	6	1	9
14	R:R:F93	11.32	4	1	7
15	R:R:V101	6.655	4	1	5
16	R:R:F102	6.578	5	1	6
17	R:R:V105	5.05	4	1	6
18	R:R:D106	6.956	5	1	5
19	R:R:L109	7.55	4	1	8
20	R:R:V113	4.41	4	1	8
21	R:R:I116	5.8925	4	1	8
22	R:R:I119	5.06	4	1	9
23	R:R:R123	6.195	4	1	9
24	R:R:R137	9.805	4	0	6
25	R:R:V160	4.47	4	1	4
26	R:R:F178	9.144	5	0	4
27	R:R:F180	9.294	5	0	5
28	R:R:V195	2.8575	4	0	4
29	R:R:R201	7.88	4	1	5
30	R:R:R205	10.065	6	1	6
31	R:R:F210	8.4575	4	1	8
32	R:R:P213	3.3	4	0	9
33	R:R:Y221	5.90333	6	1	8
34	R:R:R238	2.9525	4	0	7
35	R:R:F250	5.956	5	1	9
36	R:R:W254	6.01	7	1	9
37	R:R:S255	5.5875	4	0	6
38	R:R:Y257	4.96	7	1	7
39	R:R:Q258	7.42	5	1	8
40	R:R:I279	4.4975	4	0	5
41	R:R:F291	7.536	5	1	7
42	R:R:F292	4.2175	4	4	5
43	R:R:N293	7.624	5	1	9
44	R:R:N297	6.52	4	1	9
45	R:R:L300	3.27	4	0	8
46	R:R:Y301	5.466	5	1	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D106	20.5851	17.23	Yes	Yes	1	0	5
2	L:L:L2	R:R:D106	17.984	4.07	Yes	Yes	1	0	5
3	L:L:?1	R:R:R201	21.6102	13.22	Yes	Yes	1	0	5
4	R:R:F178	R:R:R201	16.7992	9.62	Yes	Yes	0	4	5
5	L:L:I4	R:R:F178	11.4863	8.79	No	Yes	0	0	4
6	R:R:F74	R:R:L109	20.3618	12.18	Yes	Yes	1	7	8
7	R:R:F74	R:R:V105	18.2057	3.93	Yes	Yes	1	7	6
8	L:L:?1	R:R:R205	30.779	24.23	Yes	Yes	1	0	6
9	L:L:F3	R:R:R205	37.7559	8.55	Yes	Yes	1	0	6
10	L:L:?1	R:R:Y257	32.5277	6.38	Yes	Yes	1	0	7
11	L:L:F3	R:R:Y257	54.1819	5.16	Yes	Yes	1	0	7
12	L:L:F3	L:L:I5	67.8292	10.05	Yes	Yes	0	0	0
13	L:L:I4	R:R:F102	16.7373	10.05	No	Yes	0	0	6
14	R:R:F102	R:R:V105	24.1574	3.93	Yes	Yes	1	6	6
15	R:R:F178	R:R:F180	15.9208	13.93	Yes	Yes	0	4	5
16	R:R:F180	R:R:L198	12.8096	4.87	Yes	No	0	5	4
17	L:L:I5	R:R:L198	27.7363	8.56	Yes	No	0	0	4
18	L:L:I5	R:R:L272	25.7285	5.71	Yes	No	0	0	1
19	R:R:F291	R:R:F33	14.7849	5.36	Yes	Yes	0	7	7
20	R:R:F33	R:R:T29	10.2086	3.89	Yes	No	0	7	5
21	L:L:?1	R:R:W254	39.6578	4.13	Yes	Yes	1	0	9
22	R:R:N293	R:R:W254	27.0225	9.04	Yes	Yes	1	9	9
23	R:R:L296	R:R:N293	18.5756	4.12	No	Yes	0	6	9
24	R:R:N293	R:R:N297	10.8849	12.26	Yes	Yes	1	9	9
25	L:L:?1	R:R:V113	31.9052	4.05	Yes	Yes	1	0	8
26	R:R:F250	R:R:V113	29.4703	3.93	Yes	Yes	1	9	8
27	R:R:F250	R:R:I116	100	8.79	Yes	Yes	1	9	8
28	R:R:I116	R:R:Y301	99.9153	4.84	Yes	Yes	1	8	9
29	R:R:Y301	R:R:Y64	36.0398	5.96	Yes	Yes	1	9	8
30	R:R:V302	R:R:Y64	16.6672	5.05	No	Yes	0	7	8
31	R:R:F303	R:R:V302	14.2405	6.55	No	No	0	7	7
32	R:R:F303	R:R:L46	11.8823	6.09	No	No	0	7	7
33	R:R:F250	R:R:W254	68.8315	6.01	Yes	Yes	1	9	9
34	R:R:T60	R:R:Y64	18.3035	6.24	No	Yes	0	7	8
35	R:R:R137	R:R:T60	17.1969	3.88	Yes	No	0	6	7
36	R:R:R137	R:R:V59	12.9677	13.08	Yes	No	0	6	7
37	R:R:A142	R:R:V59	11.8677	5.09	No	No	0	7	7
38	R:R:A142	R:R:I62	10.7774	3.25	No	No	0	7	6
39	R:R:R123	R:R:Y301	31.0838	4.12	Yes	Yes	1	9	9
40	R:R:D106	R:R:V160	13.2024	4.38	Yes	Yes	1	5	4
41	R:R:T103	R:R:V160	22.9188	3.17	No	Yes	0	6	4
42	R:R:I161	R:R:T103	21.3331	7.6	No	No	0	5	6
43	R:R:I161	R:R:L158	18.1682	2.85	No	No	0	5	4
44	R:R:L154	R:R:L158	16.589	1.38	No	No	0	3	4
45	R:R:L154	R:R:L155	15.0391	1.38	No	No	0	3	3
46	R:R:L155	R:R:V151	13.4941	1.49	No	No	0	3	4
47	R:R:G148	R:R:V151	10.8344	1.84	No	No	0	2	4
48	R:R:F102	R:R:V101	43.2187	3.93	Yes	Yes	1	6	5
49	R:R:F80	R:R:V101	19.8908	11.8	Yes	Yes	1	6	5
50	R:R:V101	R:R:W91	22.1757	6.13	Yes	Yes	1	5	9
51	R:R:F80	R:R:F93	17.575	13.93	Yes	Yes	1	6	7
52	R:R:F93	R:R:W91	17.6548	17.04	Yes	Yes	1	7	9
53	R:R:F93	R:R:P92	32.9221	5.78	Yes	No	1	7	2
54	R:R:H90	R:R:P92	23.5316	6.1	Yes	No	1	4	2
55	R:R:H90	R:R:V174	11.8302	8.3	Yes	No	0	4	5
56	R:R:R123	R:R:Y221	33.3752	9.26	Yes	Yes	1	9	8
57	R:R:A120	R:R:Y221	39.3074	5.34	No	Yes	0	9	8
58	R:R:V246	R:R:Y301	33.7549	7.57	No	Yes	0	8	9
59	R:R:V246	R:R:Y221	31.2419	6.31	No	Yes	0	8	8
60	R:R:A120	R:R:S220	34.9919	3.42	No	No	0	9	8
61	R:R:C124	R:R:S220	32.8292	5.16	No	No	0	8	8
62	R:R:C124	R:R:L128	28.4941	3.17	No	No	0	8	8
63	R:R:K227	R:R:L128	19.7816	4.23	No	No	0	5	8
64	R:R:K227	R:R:P130	17.5978	1.67	No	No	0	5	8
65	R:R:H129	R:R:P130	15.4107	3.05	No	No	0	7	8
66	R:R:H129	R:R:W132	11.0235	7.41	No	No	0	7	4
67	L:L:I5	R:R:T177	16.4798	3.04	Yes	No	0	0	4
68	R:R:T177	R:R:V167	14.5779	4.76	No	No	0	4	1
69	R:R:N179	R:R:V167	10.4286	4.43	No	No	0	4	1
70	R:R:I268	R:R:L198	33.3377	5.71	No	No	0	3	4
71	R:R:I268	R:R:V195	52.9009	3.07	No	Yes	0	3	4
72	R:R:R269	R:R:V195	24.4834	5.23	No	Yes	0	1	4
73	R:R:N192	R:R:R269	20.4107	3.62	No	No	0	3	1
74	R:R:E189	R:R:N192	16.3347	6.57	No	No	0	4	3
75	R:R:I268	R:R:L272	23.8641	7.14	No	No	0	3	1
76	R:R:I191	R:R:V195	16.3347	1.54	No	Yes	0	2	4
77	R:R:Q258	R:R:R205	13.6147	9.35	Yes	Yes	1	8	6
78	R:R:Q258	R:R:W254	27.1578	3.29	Yes	Yes	1	8	9
79	R:R:Q258	R:R:Y257	14.1965	3.38	Yes	Yes	1	8	7
80	R:R:L243	R:R:Y221	17.6076	8.21	No	Yes	1	7	8
81	R:R:A225	R:R:L243	15.5623	1.58	No	No	0	5	7
82	R:R:A225	R:R:L240	11.2402	1.58	No	No	0	5	6
83	R:R:A249	R:R:L296	13.8136	1.58	No	No	0	7	6
84	R:R:A249	R:R:L300	13.1829	1.58	No	Yes	0	7	8
85	R:R:L300	R:R:M304	10.2999	2.83	Yes	No	0	8	7
86	R:R:A290	R:R:W254	13.0052	7.78	No	Yes	0	8	9
87	R:R:A290	R:R:Y257	12.7754	4	No	Yes	0	8	7
88	L:L:F3	R:R:A264	23.7533	2.77	Yes	No	0	0	4
89	R:R:A264	R:R:I279	20.7953	3.25	No	Yes	0	4	5
90	R:R:I279	R:R:Y276	11.9019	6.04	Yes	No	0	5	1
91	L:L:L2	R:R:F291	10.8735	3.65	Yes	Yes	1	0	7
92	R:R:L109	R:R:W254	20.2689	5.69	Yes	Yes	1	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D106	17.23	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L109	5.02	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:F110	22.09	1	Yes	No	0	7	0	1
L:L:?1	R:R:V113	4.05	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:R201	13.22	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:R205	24.23	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:W254	4.13	1	Yes	Yes	0	9	0	1
L:L:?1	R:R:Y257	6.38	1	Yes	Yes	0	7	0	1
L:L:L2	R:R:F81	6.09	1	Yes	No	0	6	0	1
L:L:L2	R:R:V105	4.47	1	Yes	Yes	0	6	0	1
L:L:L2	R:R:D106	4.07	1	Yes	Yes	0	5	0	1
L:L:L2	R:R:F291	3.65	1	Yes	Yes	0	7	0	1
L:L:F3	R:R:R205	8.55	1	Yes	Yes	0	6	0	1
L:L:F3	R:R:Y257	5.16	1	Yes	Yes	0	7	0	1
L:L:I4	R:R:F102	10.05	0	No	Yes	0	6	0	1
L:L:I4	R:R:F178	8.79	0	No	Yes	0	4	0	1
L:L:I5	R:R:L198	8.56	0	Yes	No	0	4	0	1
L:L:I5	R:R:L272	5.71	0	Yes	No	0	1	0	1
R:R:F291	R:R:F33	5.36	1	Yes	Yes	7	7	1	2
R:R:F74	R:R:V105	3.93	1	Yes	Yes	7	6	2	1
R:R:F74	R:R:L109	12.18	1	Yes	Yes	7	8	2	1
R:R:F291	R:R:F74	16.08	1	Yes	Yes	7	7	1	2
R:R:F102	R:R:F81	6.43	1	Yes	No	6	6	1	1
R:R:F81	R:R:V105	7.87	1	No	Yes	6	6	1	1
R:R:F102	R:R:R84	8.55	1	Yes	No	6	5	1	2
R:R:F102	R:R:V101	3.93	1	Yes	Yes	6	5	1	2
R:R:F102	R:R:V105	3.93	1	Yes	Yes	6	6	1	1
R:R:D106	R:R:T157	4.34	1	Yes	No	5	7	1	2
R:R:D106	R:R:V160	4.38	1	Yes	Yes	5	4	1	2
R:R:D106	R:R:R201	4.76	1	Yes	Yes	5	5	1	1
R:R:L109	R:R:W254	5.69	1	Yes	Yes	8	9	1	1
R:R:F291	R:R:L109	7.31	1	Yes	Yes	7	8	1	1
R:R:F110	R:R:F114	7.5	0	No	No	7	6	1	2
R:R:F110	R:R:L156	7.31	0	No	No	7	5	1	2
R:R:P213	R:R:V113	3.53	0	Yes	Yes	9	8	2	1
R:R:F250	R:R:V113	3.93	1	Yes	Yes	9	8	2	1
R:R:V113	R:R:W254	6.13	1	Yes	Yes	8	9	1	1
R:R:V160	R:R:V164	6.41	1	Yes	No	4	5	2	2
R:R:R201	R:R:V160	3.92	1	Yes	Yes	5	4	1	2
R:R:F178	R:R:V164	10.49	0	Yes	No	4	5	1	2
R:R:T177	R:R:V167	4.76	0	No	No	4	1	1	2
R:R:F178	R:R:F180	13.93	0	Yes	Yes	4	5	1	2
R:R:F178	R:R:R201	9.62	0	Yes	Yes	4	5	1	1
R:R:F180	R:R:L198	4.87	0	Yes	No	5	4	2	1
R:R:I268	R:R:L198	5.71	0	No	No	3	4	2	1
R:R:G202	R:R:R205	4.5	0	No	Yes	5	6	2	1
R:R:R205	R:R:Y257	8.23	1	Yes	Yes	6	7	1	1
R:R:Q258	R:R:R205	9.35	1	Yes	Yes	8	6	2	1
R:R:A261	R:R:R205	5.53	0	No	Yes	6	6	2	1
R:R:F250	R:R:W254	6.01	1	Yes	Yes	9	9	2	1
R:R:F250	R:R:N293	4.83	1	Yes	Yes	9	9	2	2
R:R:Q258	R:R:W254	3.29	1	Yes	Yes	8	9	2	1
R:R:A290	R:R:W254	7.78	0	No	Yes	8	9	2	1
R:R:N293	R:R:W254	9.04	1	Yes	Yes	9	9	2	1
R:R:Q258	R:R:Y257	3.38	1	Yes	Yes	8	7	2	1
R:R:T286	R:R:Y257	3.75	0	No	Yes	7	7	2	1
R:R:S287	R:R:Y257	3.82	0	No	Yes	6	7	2	1
R:R:A290	R:R:Y257	4	0	No	Yes	8	7	2	1
R:R:A264	R:R:I279	3.25	0	No	Yes	4	5	1	2
R:R:I268	R:R:L272	7.14	0	No	No	3	1	2	1
R:R:F291	R:R:S287	5.28	1	Yes	No	7	6	1	2
L:L:I5	R:R:T177	3.04	0	Yes	No	0	4	0	1
R:R:F178	R:R:P159	2.89	0	Yes	No	4	8	1	2
L:L:F3	R:R:A264	2.77	1	Yes	No	0	4	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7T6T_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.25
Number of Linked Nodes	281
Number of Links	329
Number of Hubs	46
Number of Links mediated by Hubs	160
Number of Communities	6
Number of Nodes involved in Communities	59
Number of Links involved in Communities	86

Path Summary
Number Of Nodes in MetaPath	93
Number Of Links MetaPath	92
Number of Shortest Paths	132917
Length Of Smallest Path	3
Average Path Length	14.3255
Length of Longest Path	30
Minimum Path Strength	1.195
Average Path Strength	6.1517
Maximum Path Strength	23.16
Minimum Path Correlation	0.7
Average Path Correlation	0.925874
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	44.053
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	54.2704
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• RAGE receptor binding • protein binding • binding • signaling receptor binding • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • complement receptor activity • immune receptor activity • scavenger receptor binding • peptide receptor activity • N-formyl peptide receptor activity • G protein-coupled peptide receptor activity • G protein-coupled receptor binding • chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling
Gene Ontology	Biological Process	• chemotaxis • response to stimulus • taxis • response to chemical • response to external stimulus • locomotion • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • cellular response to stimulus • nitric oxide mediated signal transduction • regulation of biological process • regulation of cellular process • signaling • intracellular signal transduction • cell communication • intracellular signaling cassette • cellular process • signal transduction • phospholipase C-activating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • immune response-regulating cell surface receptor signaling pathway • complement receptor mediated signaling pathway • positive regulation of biological process • positive regulation of response to stimulus • immune response-activating signaling pathway • immune response-regulating signaling pathway • positive regulation of immune response • regulation of immune system process • positive regulation of immune system process • cell surface receptor signaling pathway • immune response-activating cell surface receptor signaling pathway • immune response • regulation of response to stimulus • immune system process • regulation of immune response • activation of immune response • defense response • response to stress • inflammatory response • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule
Gene Ontology	Cellular Component	• membrane-bounded organelle • intracellular anatomical structure • membrane • intracellular vesicle • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • cytoplasmic vesicle membrane • cellular anatomical structure • bounding membrane of organelle • vesicle membrane • cytoplasmic vesicle • organelle • secretory granule • secretory vesicle • cytoplasm • vesicle • organelle membrane • secretory granule membrane • lytic vacuole • lysosome • vacuolar membrane • azurophil granule • vacuole • lytic vacuole membrane • lysosomal membrane • primary lysosome • azurophil granule membrane • ficolin-1-rich granule membrane • ficolin-1-rich granule • tertiary granule • cell periphery • plasma membrane • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • cellular response to stimulus • response to dopamine • regulation of cellular process • response to stimulus • signaling • cellular response to dopamine • response to monoamine • cell communication • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • signal transduction • regulation of biological process • G protein-coupled dopamine receptor signaling pathway • biological regulation • response to oxygen-containing compound • response to nitrogen compound • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • cellular process • G protein-coupled receptor signaling pathway • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • plasma membrane region • cell projection membrane • synapse • cell junction • cell body • D2 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • enzyme regulator activity • adenylate cyclase inhibitor activity • cyclase regulator activity • molecular function inhibitor activity • cyclase inhibitor activity • molecular function regulator activity • enzyme inhibitor activity • adenylate cyclase regulator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • cation binding • magnesium ion binding • metal ion binding • GDP binding • G protein-coupled serotonin receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • adenylate cyclase-inhibiting serotonin receptor signaling pathway • G protein-coupled serotonin receptor signaling pathway • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • response to peptide hormone • cell division • leukocyte migration • immune system process • mononuclear cell migration • lymphocyte migration • cell migration • T cell migration • cell motility • regulation of steroid biosynthetic process • regulation of cholesterol biosynthetic process • regulation of cholesterol metabolic process • steroid metabolic process • regulation of lipid metabolic process • sterol metabolic process • positive regulation of biological process • cholesterol metabolic process • lipid biosynthetic process • alcohol metabolic process • regulation of primary metabolic process • positive regulation of metabolic process • regulation of small molecule metabolic process • positive regulation of biosynthetic process • positive regulation of lipid metabolic process • small molecule metabolic process • steroid biosynthetic process • positive regulation of cellular process • regulation of biosynthetic process • secondary alcohol biosynthetic process • regulation of alcohol biosynthetic process • small molecule biosynthetic process • regulation of steroid metabolic process • cholesterol biosynthetic process • positive regulation of cholesterol biosynthetic process • primary metabolic process • secondary alcohol metabolic process • positive regulation of steroid biosynthetic process • biosynthetic process • sterol biosynthetic process • positive regulation of lipid biosynthetic process • regulation of sterol biosynthetic process • alcohol biosynthetic process • positive regulation of cholesterol metabolic process • positive regulation of steroid metabolic process • metabolic process • regulation of lipid biosynthetic process • positive regulation of small molecule metabolic process • regulation of metabolic process • positive regulation of alcohol biosynthetic process • positive regulation of sterol biosynthetic process • lipid metabolic process • negative regulation of protein transport • regulation of localization • establishment of protein localization • nitrogen compound transport • negative regulation of biological process • negative regulation of transport • localization • negative regulation of secretion • negative regulation of hormone secretion • negative regulation of secretion by cell • intracellular protein localization • regulation of peptide hormone secretion • negative regulation of peptide hormone secretion • regulation of hormone levels • establishment of protein localization to extracellular region • negative regulation of establishment of protein localization • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • negative regulation of protein secretion • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • negative regulation of signaling • hormone secretion • negative regulation of cell communication • protein localization to extracellular region • negative regulation of peptide secretion • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • negative regulation of cellular process • negative regulation of protein localization • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • regulation of protein transport • peptide transport • negative regulation of insulin secretion • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • regulation of cell communication • insulin secretion • regulation of cytoskeleton organization • regulation of cellular component organization • microtubule cytoskeleton organization • regulation of mitotic spindle organization • mitotic cell cycle • cellular component organization • cell cycle • cellular component organization or biogenesis • regulation of cell cycle • microtubule cytoskeleton organization involved in mitosis • spindle organization • cell cycle process • regulation of cell cycle process • regulation of microtubule-based process • regulation of spindle organization • regulation of organelle organization • mitotic spindle organization • organelle organization • mitotic cell cycle process • microtubule-based process • cytoskeleton organization • regulation of microtubule cytoskeleton organization • positive regulation of protein localization to cell periphery • protein localization to cell periphery • positive regulation of protein localization to cell cortex • regulation of protein localization to cell periphery • regulation of protein localization to cell cortex • positive regulation of protein localization • protein localization to cell cortex • cellular response to forskolin • response to forskolin • midbody • nucleus • membrane-enclosed lumen • intracellular membraneless organelle • nucleolus • intracellular organelle lumen • organelle lumen • membraneless organelle • nuclear lumen • cell cortex • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • extracellular membrane-bounded organelle • centrosome • microtubule organizing center • cytoskeleton • microtubule cytoskeleton • centriolar satellite • cytosol • nucleoplasm • Golgi apparatus • ciliary basal body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain • Ras-like P-loop GTPases
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	FME
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	FME
Name	N-Formylmethionine
Synonyms	Formyl-methionine N-Formylmethionine N-formyl-L-methionine (2S)-2-(formylamino)-4-(methylthio)butanoic acid L-N-Formylmethionine
Identifier
Formula	C6 H11 N O3 S
Molecular Weight	177.221
SMILES
PubChem	439750
Formal Charge	0
Total Atoms	22
Total Chiral Atoms	1
Total Bonds	21
Total Aromatic Bonds	0


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P21462
Sequence	>7T6T_nogp_Chain_R G Y L F L D I I T Y L V F A V T F V L G V L G N G L V I W V A G F R M T H T V T T I S Y L N L A V A D F C F T S T L P F F M V R K A M G G H W P F G W F L C K F V F T I V D I N L F G S V F L I A L I A L D R C V C V L H P V W T Q N H R T V S L A K K V I I G P W V M A L L L T L P V I I R V T T V P G K T G T V A C T F N F S P W T N D P K E R I N V A V A M L T V R G I I R F I I G F S A P M S I V A V S Y G L I A T K I H K Q G L I K S S R P L R V L S F V A A A F F L C W S P Y Q V V A L I A T V R I R E L L Q G M Y K E I G I A V D V T S A L A F F N S C L N P M L Y V F M G Q D F R E R L I H A L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7T6T	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-	Gi1/β1/γ2	3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7T6T (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLFII	-		3.2	2022-03-30	doi.org/10.1038/s41467-022-28586-0
	7WVU	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7WVU (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		3.3	2022-04-13	doi.org/10.1038/s41467-022-29361-x
	7EUO	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7EUO (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.9	2022-05-25	doi.org/10.1038/s41467-022-32822-y
	7VFX	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-	Gi1/β1/γ2	2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y
	7VFX (No Gprot)	A	Peptide	Formylpeptide	FPR1-ALX	Homo sapiens	fMLF	-		2.8	2022-09-21	doi.org/10.1038/s41467-022-32822-y

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