Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N23 7.495427
2A:A:N50 7.88754209
3A:A:I56 5.6025487
4A:A:I207 4.86419
5A:A:F219 8.484508
6A:A:F222 8.518517
7A:A:V224 5.905419
8A:A:Q227 6.164519
9A:A:R232 7.34418
10A:A:K233 6.34714719
11A:A:W234 6.08667619
12A:A:C237 4.4725418
13A:A:F238 10.245419
14A:A:F246 5.85409
15A:A:V247 4.065487
16A:A:Y253 7.97408
17A:A:R265 8.16254209
18A:A:F273 6.58579
19A:A:W277 9.354576
20A:A:W281 15.014515
21A:A:I285 3.345407
22A:A:I288 5.6025489
23A:A:F290 5.04667689
24A:A:N292 4.62589
25A:A:Q294 8.52476
26A:A:F315 11.278506
27A:A:Y318 8.1406
28A:A:P321 4.07405
29A:A:E330 8.91403
30A:A:V334 4.535404
31A:A:K338 9.605475
32A:A:Y339 8.3825473
33A:A:R342 7.0975474
34A:A:F345 8.4325408
35A:A:L346 4.4474
36A:A:R356 4.685402
37A:A:Y358 9.65254104
38A:A:C359 4.32475
39A:A:Y360 6.9125108
40A:A:F363 10.12575
41A:A:T364 5.665489
42A:A:D368 7.4925489
43A:A:F376 6.657147148
44A:A:R385 9.31254105
45A:A:Y391 5.4775404
46A:A:L394 3.6475408
47B:B:L7 7.3654228
48B:B:I37 4.166502
49B:B:V40 3.165403
50B:B:L51 7.7475409
51B:B:H54 8.986509
52B:B:K57 11.934519
53B:B:Y59 8.024518
54B:B:W63 7.652507
55B:B:R68 11.0275425
56B:B:L69 5.055425
57B:B:V71 4.252528
58B:B:Q75 9.9325419
59B:B:D76 6.375189
60B:B:K78 6.32408
61B:B:L79 5.01527
62B:B:I81 4.28143727
63B:B:W82 12.4409
64B:B:D83 9.8525428
65B:B:Y85 9.4424
66B:B:K89 7.546529
67B:B:I93 5.022507
68B:B:L95 4.492528
69B:B:W99 10.325419
70B:B:M101 5.308519
71B:B:Y105 3.88875826
72B:B:V112 4.075628
73B:B:L117 4.625619
74B:B:I123 3.915276
75B:B:Y124 6.23667626
76B:B:L126 3.8125425
77B:B:E130 7.6025403
78B:B:L139 7.07409
79B:B:H142 9.198519
80B:B:Y145 6.975818
81B:B:L146 3.35417
82B:B:F151 3.59667609
83B:B:Q156 8.6175405
84B:B:I157 3.9375407
85B:B:T159 4.345419
86B:B:D163 9.022519
87B:B:C166 4.235458
88B:B:W169 10.23518
89B:B:Q176 6.465414
90B:B:F180 9.136557
91B:B:H183 9.47167659
92B:B:D186 7.075419
93B:B:V187 4.426559
94B:B:L190 4.275455
95B:B:F199 8.17667659
96B:B:V200 7.525466
97B:B:S201 4.915459
98B:B:C204 7.29417
99B:B:D205 6.656559
100B:B:K209 13.49456
101B:B:L210 5.19405
102B:B:W211 8.80667658
103B:B:Q220 9.305467
104B:B:F222 8.95468
105B:B:H225 10.1671769
106B:B:D228 10.28419
107B:B:I232 5.025468
108B:B:F235 8.2025156
109B:B:P236 7.42254157
110B:B:F241 7.504566
111B:B:T243 5.8975468
112B:B:D247 10.498569
113B:B:T249 7.958566
114B:B:R251 12.235668
115B:B:F253 8.078566
116B:B:D254 7.934299
117B:B:R256 9.5045299
118B:B:D258 9.195467
119B:B:Q259 4.3475406
120B:B:E260 8.575466
121B:B:L261 4.525405
122B:B:Y264 6.026505
123B:B:F278 6.7554157
124B:B:G282 3.76254159
125B:B:L285 5.4406
126B:B:Y289 7.61717
127B:B:D290 9.5416
128B:B:V296 3.584305
129B:B:W297 6.2225418
130B:B:K301 4.2725405
131B:B:H311 8.86529
132B:B:R314 18.8775418
133B:B:L318 3.0925406
134B:B:T321 7.04754257
135B:B:T329 6.4475408
136B:B:W332 13.1629719
137B:B:D333 6.184529
138B:B:K337 8.468526
139B:B:W339 11.196529
140B:B:N340 8.474529
141G:G:Q11 5.255403
142G:G:L15 5.56254222
143G:G:E22 8.425409
144G:G:Y40 11.82754156
145G:G:D48 6.4225249
146G:G:L51 4.3265246
147G:G:N59 5.76429
148G:G:P60 7.1275429
149G:G:F61 7.435828
150R:R:P218 7.1854312
151R:R:D229 7.62754165
152R:R:E235 6.1644
153R:R:R238 8.27444
154R:R:R254 3.6065326
155R:R:W256 6.1125128
156R:R:W260 4.718336125
157R:R:Y275 9.192538
158R:R:D278 5.098539
159R:R:R281 9.5639
160R:R:F282 9539
161R:R:Y284 6.10167639
162R:R:E286 5.0275439
163R:R:R287 5.3625439
164R:R:F291 8.1275438
165R:R:Y296 6.5125498
166R:R:F297 6.144505
167R:R:H303 4.03254126
168R:R:R318 8.1454314
169R:R:Y324 7.845442
170R:R:R325 6.62444
171R:R:T326 6.868545
172R:R:Q329 5.574177
173R:R:L343 3.335406
174R:R:F345 7.1475408
175R:R:W353 9.49639
176R:R:W354 10.024599
177R:R:H382 5.1225439
178R:R:S408 3.83408
179R:R:Y412 4.1165136
180R:R:V413 5.0065139
181R:R:V425 4.78754138
182R:R:Y432 5.57406
183R:R:T437 2.89497
184R:R:F444 7.955408
185R:R:R451 6.48254349
186R:R:D457 4.185406
187R:R:Y478 12.225498
188R:R:Y489 5.63404
189R:R:W499 5.09667649
190R:R:W503 7.12545
191R:R:F527 4.4475406
192R:R:M538 4.61754128
193R:R:V540 4.9575498
194R:R:W547 5.14539
195R:R:S550 3.7825439
196R:R:T553 4.7175439
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I56 A:A:N292 33.90175.66YesYes879
2A:A:K293 A:A:N292 1008.39NoYes099
3A:A:D249 A:A:K293 99.992316.59NoNo089
4A:A:D249 A:A:S251 99.93752.94NoNo089
5A:A:K300 A:A:S251 99.92153.06NoNo099
6A:A:K300 A:A:Y253 99.905410.75NoYes098
7A:A:L297 A:A:Y253 98.94463.52NoYes088
8A:A:L297 A:A:Q294 98.8876.65NoYes786
9A:A:F363 A:A:Q294 98.095810.54YesYes756
10A:A:F363 A:A:R342 39.41057.48YesYes754
11A:A:L346 A:A:R342 40.01264.86YesYes744
12A:A:L346 A:A:S349 19.27843YesNo747
13A:A:S349 A:A:W277 19.26478.65NoYes776
14A:A:H357 A:A:W277 16.919423.27NoYes076
15A:A:H357 A:A:R356 16.88294.51NoYes072
16A:A:R283 A:A:R356 16.74343.2NoYes032
17A:A:R280 A:A:R283 16.70658.53NoNo053
18A:A:R280 A:A:W281 16.670422.99NoYes055
19A:A:F290 A:A:I56 32.94977.54YesYes897
20A:A:F290 A:A:V247 32.88323.93YesYes897
21A:A:N292 A:A:V247 32.93212.96YesYes897
22A:A:F290 A:A:T364 32.87275.19YesYes899
23A:A:N292 A:A:T364 33.21674.39YesYes899
24B:B:H142 B:B:L146 10.11523.86YesYes197
25B:B:C149 B:B:T102 18.67536.76NoNo088
26B:B:C148 B:B:T102 18.27833.38NoNo068
27B:B:H142 B:B:T159 14.10454.11YesYes199
28B:B:I157 B:B:T159 13.92963.04YesYes079
29A:A:W234 B:B:Y145 66.92885.79YesYes198
30A:A:R231 A:A:W234 72.12214NoYes099
31A:A:L272 A:A:R231 72.2968.5NoNo089
32A:A:K233 B:B:D228 34.52839.68YesYes199
33A:A:F290 A:A:I288 97.39425.02YesYes899
34A:A:F246 A:A:L272 72.47127.31YesNo098
35A:A:F246 A:A:V248 18.17133.93YesNo097
36A:A:F273 A:A:F345 20.42117.5YesYes098
37A:A:C359 A:A:F273 41.00994.19YesYes759
38A:A:D378 A:A:I288 97.523211.2NoYes079
39A:A:D378 A:A:Y360 97.523312.64NoYes078
40A:A:F345 A:A:L289 38.78237.31YesNo089
41A:A:C359 A:A:L289 20.38144.76YesNo059
42A:A:L289 A:A:L291 59.16468.3NoNo098
43A:A:Y358 A:A:Y360 48.84572.98YesYes1048
44A:A:R385 A:A:Y358 48.251925.72YesYes1054
45A:A:D381 A:A:Y360 48.358411.49NoYes088
46A:A:D381 A:A:R385 48.24434.76NoYes085
47A:A:R385 R:R:D457 96.28283.57YesYes056
48R:R:D457 R:R:M454 95.57416.93YesNo068
49A:A:L394 R:R:W361 38.98833.42YesNo089
50R:R:F444 R:R:W361 39.233612.03YesNo089
51R:R:F444 R:R:L467 92.97274.87YesNo089
52R:R:K463 R:R:L467 93.68272.82NoNo099
53R:R:K463 R:R:R451 93.91927.43NoYes099
54R:R:K460 R:R:R451 94.38487.43NoYes3479
55R:R:K460 R:R:M454 94.86517.2NoNo078
56A:A:L394 R:R:W547 36.04183.42YesYes089
57B:B:L14 G:G:E22 18.54856.63NoYes089
58B:B:L14 G:G:L15 13.60561.38NoYes082
59B:B:L7 G:G:L15 11.7515.54YesYes2282
60B:B:H142 B:B:S161 27.625416.74YesNo199
61B:B:G162 B:B:Y145 28.87898.69NoYes198
62B:B:G162 B:B:S161 28.87353.71NoNo199
63B:B:C148 B:B:L190 17.23784.76NoYes065
64B:B:F199 B:B:L190 10.73224.87YesYes595
65B:B:D228 B:B:S227 34.51875.89YesNo096
66B:B:S227 B:B:S245 34.32743.26NoNo069
67B:B:H225 B:B:S245 23.548913.95YesNo699
68B:B:H225 B:B:T243 12.58818.21YesYes698
69B:B:D247 B:B:S245 10.57418.83YesNo699
70B:B:D258 G:G:R27 20.15917.15YesNo078
71R:R:F444 R:R:L440 54.12294.87YesNo088
72R:R:L440 R:R:S358 53.6373NoNo088
73R:R:G436 R:R:S358 53.3943.71NoNo098
74R:R:G436 R:R:W354 53.15094.22NoYes099
75R:R:W354 R:R:Y478 50.953737.62YesYes998
76R:R:V540 R:R:Y478 49.97633.79YesYes988
77R:R:P481 R:R:V540 49.49693.53NoYes098
78R:R:M536 R:R:P481 48.76586.71NoNo089
79R:R:M536 R:R:V485 48.27823.04NoNo088
80R:R:V485 R:R:Y489 47.79055.05NoYes084
81R:R:K533 R:R:Y489 27.80834.78NoYes094
82R:R:C488 R:R:K533 18.45929.7NoNo089
83R:R:C488 R:R:V529 18.21113.42NoNo087
84R:R:V529 R:R:Y491 17.21868.83NoNo079
85R:R:W499 R:R:Y491 16.72213.86YesNo099
86R:R:W499 R:R:W503 12.74254.69YesYes495
87R:R:Q506 R:R:W503 11.99669.86NoYes435
88R:R:Q506 R:R:R238 11.74945.84NoYes434
89R:R:Y412 R:R:Y489 19.13745.96YesYes064
90R:R:M538 R:R:W260 10.46113.49YesYes1285
91R:R:F282 R:R:W547 28.6075.01YesYes399
92R:R:F282 R:R:I290 26.18416.33YesNo398
93R:R:I290 R:R:Y275 14.963418.13NoYes388
94R:R:F291 R:R:I290 10.97323.77YesNo388
95R:R:R287 R:R:Y284 11.48913.09YesYes399
96B:B:F253 B:B:R251 17.0565.34YesYes668
97B:B:F222 B:B:F253 23.745510.72YesYes686
98A:A:F363 A:A:L291 59.1673.65YesNo058
99A:A:C359 A:A:L346 20.71643.17YesYes754
100A:A:K233 B:B:Y145 35.99844.78YesYes198
101B:B:D258 B:B:F222 22.03375.97YesYes678
102G:G:E22 G:G:R27 19.59933.49YesNo098
103A:A:F345 A:A:V248 18.22759.18YesNo087
104A:A:F246 A:A:F273 54.66559.65YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EVW
Class F
SubFamily Protein
Type Frizzled
SubType FZD7
Species Homo Sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.22
Date 2021-08-04
D.O.I. 10.1038/s41422-021-00525-6
Net Summary
Imin 2.94
Number of Linked Nodes 919
Number of Links 1140
Number of Hubs 196
Number of Links mediated by Hubs 680
Number of Communities 35
Number of Nodes involved in Communities 286
Number of Links involved in Communities 414
Path Summary
Number Of Nodes in MetaPath 105
Number Of Links MetaPath 104
Number of Shortest Paths 5728114
Length Of Smallest Path 3
Average Path Length 49.5797
Length of Longest Path 81
Minimum Path Strength 1.185
Average Path Strength 7.29268
Maximum Path Strength 23.99
Minimum Path Correlation 0.7
Average Path Correlation 0.994561
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 2.08333
Average % Of Corr. Nodes 28.4515
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.682
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7EVW_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRILHT SGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNLFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTENARRIF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EVW_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EVW_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO75084
Sequence
>7EVW_Chain_R
CPRQLKVPP YLGYRFLGE RDCGAPCEP GRANGLMYF KEEERRFAR 
LWVGVWSVL CCASTLFTV LTYLVDMRR FSYPERPII FLSGCYFMV 
AVAHVAGFL LEDRAVCVE RFSDDGYRT VAQGTKKEG CTILFMVLY 
FFGMASSIW WVILSLTWF LAAGMKWGH EAIEANSQY FHLAAWAVP 
AVKTITILA MGQVDGDLL SGVCYVGLS SVDALRGFV LAPLFVYLF 
IGTSFLLAG FVSLFRIRT IMKHDGTKT EKLEKLMVR IGVFSVLYT 
VPATIVLAC YFYEQAFRE HWERTWLLQ TCDFTVFMI KYLMTMIVG 
ITTGFWIWS GKTLQSWRR FYHRLSH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
9EPOFProteinFrizzledFZD7Homo sapiens---1.92024-10-02To be published
9EW2FProteinFrizzledFZD7Homo sapiens--Gs/β1/γ23.22024-10-02To be published
9EW2 (No Gprot) FProteinFrizzledFZD7Homo sapiens--3.22024-10-02To be published
8YY8FProteinFrizzledFZD7Homo sapiens--Gs/β1/γ23.222024-04-2410.1038/s41422-021-00525-6
8YY8 (No Gprot) FProteinFrizzledFZD7Homo sapiens--3.222024-04-2410.1038/s41422-021-00525-6
7EVW (No Gprot) FProteinFrizzledFZD7Homo sapiens--3.222021-08-0410.1038/s41422-021-00525-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EVW.zip



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