Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index Hub Avg Int. Strength Num Of Links Community ConSurf
1A:A:N23 7.495427
2A:A:N50 7.88754219
3A:A:I56 5.6025497
4A:A:I207 4.86419
5A:A:F219 8.484508
6A:A:F222 8.518517
7A:A:V224 5.905419
8A:A:Q227 6.164519
9A:A:R232 7.34418
10A:A:K233 6.34714719
11A:A:W234 6.08667619
12A:A:C237 4.4725418
13A:A:F238 10.245419
14A:A:F246 5.85409
15A:A:V247 4.065497
16A:A:Y253 7.97408
17A:A:R265 8.16254219
18A:A:F273 6.58569
19A:A:W277 9.354566
20A:A:W281 15.014515
21A:A:I285 3.345407
22A:A:I288 5.6025499
23A:A:F290 5.04667699
24A:A:N292 4.62599
25A:A:Q294 8.52466
26A:A:F315 11.278506
27A:A:Y318 8.1406
28A:A:P321 4.07405
29A:A:E330 8.91403
30A:A:V334 4.535404
31A:A:K338 9.605465
32A:A:Y339 8.3825463
33A:A:R342 7.0975464
34A:A:F345 8.4325408
35A:A:L346 4.4464
36A:A:R356 4.685402
37A:A:Y358 9.65254114
38A:A:C359 4.32465
39A:A:Y360 6.9125118
40A:A:F363 10.12565
41A:A:T364 5.665499
42A:A:D368 7.4925499
43A:A:F376 6.657147158
44A:A:R385 9.31254115
45A:A:Y391 5.4775404
46A:A:L394 3.6475408
47G:G:Q11 5.255403
48G:G:L15 5.56254232
49G:G:E22 8.425409
50G:G:Y40 11.82754166
51G:G:D48 6.4225259
52G:G:L51 4.3265256
53G:G:N59 5.76429
54G:G:P60 7.1275429
55G:G:F61 7.435828
56R:R:P218 7.1854262
57R:R:D229 7.62754175
58R:R:E235 6.1634
59R:R:R238 8.27434
60R:R:R254 3.6065276
61R:R:W256 6.1125128
62R:R:W260 4.718336125
63R:R:T274 5.205409
64R:R:Y275 9.08488
65R:R:D278 5.098579
66R:R:R281 9.5679
67R:R:F282 9.502579
68R:R:Y284 6.10167689
69R:R:E286 5.0275479
70R:R:R287 4.538589
71R:R:Y296 6.51254108
72R:R:F297 7.118505
73R:R:H303 4.03254126
74R:R:R318 8.1454264
75R:R:Y324 7.845432
76R:R:R325 6.62434
77R:R:T326 6.868535
78R:R:Q329 5.574187
79R:R:L343 3.335406
80R:R:F345 7.1475408
81R:R:W353 9.49689
82R:R:W354 10.0245109
83R:R:H382 5.1225489
84R:R:S408 3.83408
85R:R:Y412 4.1165136
86R:R:V413 5.0065139
87R:R:V425 4.78754138
88R:R:Y432 5.57406
89R:R:T437 2.894107
90R:R:F444 7.955408
91R:R:R451 6.48254299
92R:R:D457 4.185406
93R:R:Y478 12.2254108
94R:R:Y489 5.63404
95R:R:W499 5.09667639
96R:R:W503 7.12535
97R:R:F527 4.4475406
98R:R:M538 4.61754128
99R:R:V540 4.95754108
100R:R:W547 5.14579
101R:R:S550 3.7825479
102R:R:T553 4.7175479
103B:B:L7 7.3654238
104B:B:I37 4.166502
105B:B:V40 3.165403
106B:B:L51 7.7475409
107B:B:H54 8.986509
108B:B:K57 11.934519
109B:B:Y59 8.024518
110B:B:W63 7.652507
111B:B:R68 11.0275425
112B:B:L69 5.055425
113B:B:V71 4.252528
114B:B:Q75 9.9325419
115B:B:D76 6.375199
116B:B:K78 6.32408
117B:B:L79 5.01527
118B:B:I81 4.28143727
119B:B:W82 12.4409
120B:B:D83 9.8525428
121B:B:Y85 9.4424
122B:B:K89 7.546529
123B:B:I93 5.022507
124B:B:L95 4.492528
125B:B:W99 10.325419
126B:B:M101 5.308519
127B:B:Y105 3.88875826
128B:B:V112 4.075628
129B:B:L117 4.625619
130B:B:I123 3.915346
131B:B:Y124 6.23667626
132B:B:L126 3.8125425
133B:B:E130 7.6025403
134B:B:L139 7.07409
135B:B:H142 9.198519
136B:B:Y145 6.975818
137B:B:L146 3.35417
138B:B:F151 3.59667609
139B:B:Q156 8.6175405
140B:B:I157 3.9375407
141B:B:T159 4.345419
142B:B:D163 9.022519
143B:B:C166 4.235448
144B:B:W169 10.23518
145B:B:Q176 6.465414
146B:B:F180 9.136547
147B:B:H183 9.47167649
148B:B:D186 7.075419
149B:B:V187 4.426549
150B:B:L190 4.275445
151B:B:F199 8.17667649
152B:B:V200 7.525456
153B:B:S201 4.915449
154B:B:C204 7.29417
155B:B:D205 6.656549
156B:B:K209 13.49446
157B:B:L210 5.19405
158B:B:W211 8.80667648
159B:B:Q220 9.305457
160B:B:F222 8.95458
161B:B:H225 10.1671759
162B:B:D228 10.28419
163B:B:I232 5.025458
164B:B:F235 8.2025166
165B:B:P236 7.42254167
166B:B:F241 7.504556
167B:B:T243 5.8975458
168B:B:D247 10.498559
169B:B:T249 7.958556
170B:B:R251 12.235658
171B:B:F253 8.078556
172B:B:D254 7.934249
173B:B:R256 9.5045249
174B:B:D258 9.195457
175B:B:Q259 4.3475406
176B:B:E260 8.575456
177B:B:L261 4.525405
178B:B:Y264 6.026505
179B:B:F278 6.7554167
180B:B:G282 3.76254169
181B:B:L285 5.4406
182B:B:Y289 7.61717
183B:B:D290 9.5416
184B:B:V296 3.584365
185B:B:W297 6.2225418
186B:B:K301 4.2725405
187B:B:H311 8.86529
188B:B:R314 18.8775418
189B:B:L318 3.0925406
190B:B:T321 7.04754327
191B:B:T329 6.4475408
192B:B:W332 13.1629719
193B:B:D333 6.184529
194B:B:K337 8.468526
195B:B:W339 11.196529
196B:B:N340 8.474529
   

Color ConSurf Grade
      No Conservation data available
      1
      2
      3
      4
      5
      6
      7
      8
      9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index Node1 Node2 Recurrence Int. Strength Hub1? Hub2? Community ConSurf1 ConSurf2
1A:A:I56 A:A:N292 33.89945.66YesYes979
2A:A:K293 A:A:N292 1008.39NoYes099
3A:A:D249 A:A:K293 99.992116.59NoNo089
4A:A:D249 A:A:S251 99.9362.94NoNo089
5A:A:K300 A:A:S251 99.91963.06NoNo099
6A:A:K300 A:A:Y253 99.903110.75NoYes098
7A:A:L297 A:A:Y253 98.94033.52NoYes088
8A:A:L297 A:A:Q294 98.88256.65NoYes686
9A:A:F363 A:A:Q294 98.090910.54YesYes656
10A:A:F363 A:A:R342 39.40747.48YesYes654
11A:A:L346 A:A:R342 40.00614.86YesYes644
12A:A:L346 A:A:S349 19.27523YesNo647
13A:A:S349 A:A:W277 19.26138.65NoYes676
14A:A:H357 A:A:W277 16.915823.27NoYes076
15A:A:H357 A:A:R356 16.87924.51NoYes072
16A:A:R283 A:A:R356 16.73953.2NoYes032
17A:A:R280 A:A:R283 16.70268.53NoNo053
18A:A:R280 A:A:W281 16.666422.99NoYes055
19A:A:F290 A:A:I56 32.95257.54YesYes997
20A:A:F290 A:A:V247 32.8863.93YesYes997
21A:A:N292 A:A:V247 32.93452.96YesYes997
22A:A:F290 A:A:T364 32.87545.19YesYes999
23A:A:N292 A:A:T364 33.21774.39YesYes999
24B:B:H142 B:B:L146 10.11263.86YesYes197
25B:B:C149 B:B:T102 18.67026.76NoNo088
26B:B:C148 B:B:T102 18.27333.38NoNo068
27B:B:H142 B:B:T159 14.10024.11YesYes199
28B:B:I157 B:B:T159 13.92523.04YesYes079
29A:A:W234 B:B:Y145 66.91895.79YesYes198
30A:A:R231 A:A:W234 72.1134NoYes099
31A:A:L272 A:A:R231 72.28718.5NoNo089
32A:A:K233 B:B:D228 34.51969.68YesYes199
33A:A:F290 A:A:I288 97.4095.02YesYes999
34A:A:F246 A:A:L272 72.46247.31YesNo098
35A:A:F246 A:A:V248 18.16933.93YesNo097
36A:A:F273 A:A:F345 20.41897.5YesYes098
37A:A:C359 A:A:F273 41.00464.19YesYes659
38A:A:D378 A:A:I288 97.539211.2NoYes079
39A:A:D378 A:A:Y360 97.539812.64NoYes078
40A:A:F345 A:A:L289 38.77897.31YesNo089
41A:A:C359 A:A:L289 20.37964.76YesNo059
42A:A:L289 A:A:L291 59.15968.3NoNo098
43A:A:Y358 A:A:Y360 48.85372.98YesYes1148
44A:A:R385 A:A:Y358 48.262825.72YesYes1154
45A:A:D381 A:A:Y360 48.368811.49NoYes088
46A:A:D381 A:A:R385 48.25524.76NoYes085
47A:A:R385 R:R:D457 96.30583.57YesYes056
48R:R:D457 R:R:M454 95.60066.93YesNo068
49A:A:L394 R:R:W361 39.29543.42YesNo089
50R:R:F444 R:R:W361 39.539512.03YesNo089
51R:R:F444 R:R:L467 93.01224.87YesNo089
52R:R:K463 R:R:L467 93.71862.82NoNo099
53R:R:K463 R:R:R451 93.9547.43NoYes099
54R:R:K460 R:R:R451 94.41727.43NoYes2979
55R:R:K460 R:R:M454 94.89517.2NoNo078
56A:A:L394 R:R:W547 36.36353.42YesYes089
57B:B:L14 G:G:E22 18.54226.63NoYes089
58B:B:L14 G:G:L15 13.6011.38NoYes082
59B:B:L7 G:G:L15 11.7475.54YesYes2382
60B:B:C148 B:B:L190 17.23224.76NoYes065
61B:B:F199 B:B:L190 10.72844.87YesYes495
62B:B:D258 G:G:R27 20.15337.15YesNo078
63R:R:F444 R:R:L440 53.87154.87YesNo088
64R:R:L440 R:R:S358 53.38783NoNo088
65R:R:G436 R:R:S358 53.14593.71NoNo098
66R:R:G436 R:R:W354 52.9044.22NoYes099
67R:R:W354 R:R:Y478 50.71737.62YesYes1098
68R:R:V540 R:R:Y478 49.74423.79YesYes1088
69R:R:P481 R:R:V540 49.2673.53NoYes098
70R:R:M536 R:R:P481 48.53936.71NoNo089
71R:R:M536 R:R:V485 48.05393.04NoNo088
72R:R:V485 R:R:Y489 47.56855.05NoYes084
73R:R:K533 R:R:Y489 27.67914.78NoYes094
74R:R:C488 R:R:K533 18.37349.7NoNo089
75R:R:C488 R:R:V529 18.12653.42NoNo087
76R:R:V529 R:R:Y491 17.13868.83NoNo079
77R:R:W499 R:R:Y491 16.64443.86YesNo099
78R:R:W499 R:R:W503 12.68324.69YesYes395
79R:R:Q506 R:R:W503 11.94089.86NoYes335
80R:R:Q506 R:R:R238 11.69485.84NoYes334
81R:R:Y412 R:R:Y489 19.04855.96YesYes064
82R:R:M538 R:R:W260 10.41253.49YesYes1285
83R:R:F282 R:R:W547 28.96485.01YesYes799
84R:R:S293 R:R:T271 14.41969.59NoNo089
85R:R:S293 R:R:T268 13.9236.4NoNo089
86R:R:F297 R:R:T268 12.43267.78YesNo059
87R:R:F282 R:R:I290 19.099118.84YesNo098
88R:R:I290 R:R:Y275 11.45310.88NoYes088
89B:B:H142 B:B:S161 27.617816.74YesNo199
90B:B:G162 B:B:Y145 28.87178.69NoYes198
91B:B:G162 B:B:S161 28.86543.71NoNo199
92B:B:D228 B:B:S227 34.50925.89YesNo096
93B:B:S227 B:B:S245 34.31793.26NoNo069
94B:B:H225 B:B:S245 23.542513.95YesNo599
95B:B:H225 B:B:T243 12.58478.21YesYes598
96B:B:D247 B:B:S245 10.57118.83YesNo599
97B:B:F253 B:B:R251 17.05135.34YesYes568
98B:B:F222 B:B:F253 23.73910.72YesYes586
99A:A:F363 A:A:L291 59.16233.65YesNo058
100A:A:C359 A:A:L346 20.7133.17YesYes654
101A:A:K233 B:B:Y145 35.994.78YesYes198
102B:B:D258 B:B:F222 22.02725.97YesYes578
103G:G:E22 G:G:R27 19.59343.49YesNo098
104A:A:F345 A:A:V248 18.22569.18YesNo087
105A:A:F246 A:A:F273 54.65879.65YesYes099
Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.


PDB Summary
PDB 7EVW
Class F
SubFamily Protein
Type Frizzled
SubType FZD7
Species Homo sapiens
Ligand -
Other Ligand(s) -
Protein Partners Gs/Beta1/Gamma2
PDB Resolution 3.22
Date 2021-08-04
D.O.I. 10.1038/s41422-021-00525-6
Net Summary
Imin 2.94
Number of Linked Nodes 919
Number of Links 1140
Number of Hubs 196
Number of Links mediated by Hubs 681
Number of Communities 36
Number of Nodes involved in Communities 285
Number of Links involved in Communities 411
Path Summary
Number Of Nodes in MetaPath 106
Number Of Links MetaPath 105
Number of Shortest Paths 5754479
Length Of Smallest Path 3
Average Path Length 49.7045
Length of Longest Path 81
Minimum Path Strength 1.185
Average Path Strength 7.30402
Maximum Path Strength 23.99
Minimum Path Correlation 0.7
Average Path Correlation 0.994553
Maximum Path Correlation 1
Minimum % Of Corr. Nodes 1.85185
Average % Of Corr. Nodes 27.9107
Maximum % Of Corr. Nodes 100
Minimum Path Hubs % 0
Average Path Hubs % 51.1905
Maximum Path Hubs % 100

Details about the values in these tables can be found in the corresponding documentation page .
PDBsumOpen PDBsum Page
ChainA
ProteinG Protein α Sub unit
UniProtP63092
Sequence
>7EVW_Chain_A
QRNEEKAQR EANKKIEKQ LQKDKQVYR ATHRLLLLG ADNSGKSTI 
VKQMRILHT SGIFETKFQ VDKVNFHMF DVGGQRDER RKWIQCFND 
VTAIIFVVD SSDYNRLQE ALNLFKSIW NNRWLRTIS VILFLNKQD 
LLAEKVLAG KSKIEDYFP EFARYTTPE DATPEPGED PRVTRAKYF 
IRDEFLRIS TASGDGRHY CYPHFTCAV DTENARRIF NDCRDIIQR 
MHLRQYELL


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainG
ProteinG Protein γ Sub unit
UniProtP59768
Sequence
>7EVW_Chain_G
TASIAQARK LVEQLKMEA NIDRIKVSK AAADLMAYC EAHAKEDPL 
LTPVPASEN PFR


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainR
ProteinReceptor
UniProtO75084
Sequence
>7EVW_Chain_R
CPRQLKVPP YLGYRFLGE RDCGAPCEP GRANGLMYF KEEERRFAR 
LWVGVWSVL CCASTLFTV LTYLVDMRR FSYPERPII FLSGCYFMV 
AVAHVAGFL LEDRAVCVE RFSDDGYRT VAQGTKKEG CTILFMVLY 
FFGMASSIW WVILSLTWF LAAGMKWGH EAIEANSQY FHLAAWAVP 
AVKTITILA MGQVDGDLL SGVCYVGLS SVDALRGFV LAPLFVYLF 
IGTSFLLAG FVSLFRIRT IMKHDGTKT EKLEKLMVR IGVFSVLYT 
VPATIVLAC YFYEQAFRE HWERTWLLQ TCDFTVFMI KYLMTMIVG 
ITTGFWIWS GKTLQSWRR FYHRLSH


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  

ChainB
ProteinG Protein β Sub unit
UniProtP62873
Sequence
>7EVW_Chain_B
LDQLRQEAE QLKNQIRDA RKACADATL SQITNNIDP VGRIQMRTR 
RTLRGHLAK IYAMHWGTD SRLLVSASQ DGKLIIWDS YTTNKVHAI 
PLRSSWVMT CAYAPSGNY VACGGLDNI CSIYNLKTR EGNVRVSRE 
LAGHTGYLS CCRFLDDNQ IVTSSGDTT CALWDIETG QQTTTFTGH 
TGDVMSLSL APDTRLFVS GACDASAKL WDVREGMCR QTFTGHESD 
INAICFFPN GNAFATGSD DATCRLFDL RADQELMTY SHDNIICGI 
TSVSFSKSG RLLLAGYDD FNCNVWDAL KADRAGVLA GHDNRVSCL 
GVTDDGMAV ATGSWDSFL KIWN


Click on each residue to open a popup with some information about it.

ConSurf Conservation Grade (See documentation): 

 n/a   1    2    3    4    5    6    7    8    9  




This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show PDB Class SubFamily Type SubType Species Orthosteric Ligand Other Ligand(s) Protein Partners Resolution Date DOI
8YY8FProteinFrizzledFZD7Homo sapiens--Gs/&β;1/&γ;23.222024-04-2410.1038/s41422-021-00525-6




You can download a compressed (zip) file with structure(s), 3D outputs (as PyMol and VMD scripts) and numerical data files (as csv and plain text files).

Download 7EVW.zip



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