psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A40	R:R:L99	4.73	No	No	0	4	5
2	R:R:G41	R:R:L44	5.13	No	No	0	6	8
3	R:R:E47	R:R:V91	7.13	No	Yes	1	7	7
4	R:R:E47	R:R:W333	16.36	No	Yes	0	7	5
5	R:R:E47	R:R:Y336	4.49	No	Yes	1	7	7
6	R:R:P92	R:R:V48	3.53	No	No	0	8	6
7	R:R:G87	R:R:T51	5.46	No	No	0	8	7
8	R:R:A340	R:R:T51	5.03	No	No	0	6	7
9	R:R:D83	R:R:N55	6.73	Yes	No	0	9	9
10	R:R:L84	R:R:N55	6.87	No	No	0	8	9
11	R:R:N55	R:R:P343	8.15	No	No	0	9	9
12	R:R:L56	R:R:L84	5.54	No	No	0	4	8
13	R:R:F356	R:R:L57	12.18	No	No	0	7	7
14	R:R:A80	R:R:V58	3.39	No	No	0	9	9
15	R:R:C347	R:R:V58	6.83	No	No	0	7	9
16	R:R:L359	R:R:V60	4.47	Yes	No	0	5	5
17	R:R:I62	R:R:N73	5.66	Yes	No	4	7	9
18	R:R:I62	R:R:T77	4.56	Yes	No	0	7	6
19	R:R:F352	R:R:I62	5.02	Yes	Yes	4	8	7
20	R:R:L359	R:R:R64	6.07	Yes	No	0	5	5
21	R:R:P66	R:R:T65	3.5	No	Yes	0	6	6
22	R:R:R67	R:R:T65	3.88	No	Yes	0	5	6
23	R:R:L68	R:R:T65	8.84	No	Yes	0	8	6
24	R:R:R358	R:R:T65	5.17	No	Yes	0	5	6
25	R:R:F352	R:R:L68	7.31	Yes	No	0	8	8
26	R:R:T70	R:R:T72	4.71	No	No	0	8	8
27	R:R:N73	R:R:T70	5.85	No	No	0	9	8
28	R:R:D134	R:R:T72	11.56	No	No	0	9	8
29	R:R:F352	R:R:N73	8.46	Yes	No	4	8	9
30	R:R:F75	R:R:V74	3.93	Yes	No	0	8	5
31	R:R:F75	R:R:L131	7.31	Yes	No	0	8	8
32	R:R:D134	R:R:F75	3.58	No	Yes	0	9	8
33	R:R:A154	R:R:F75	4.16	No	Yes	0	7	8
34	R:R:F75	R:R:V158	3.93	Yes	No	0	8	7
35	R:R:S78	R:R:T127	4.8	No	No	0	9	8
36	R:R:S78	R:R:V158	4.85	No	No	0	9	7
37	R:R:S78	R:R:W162	8.65	No	Yes	0	9	9
38	R:R:D83	R:R:L79	9.5	Yes	No	2	9	9
39	R:R:L79	R:R:T127	4.42	No	No	0	9	8
40	R:R:L79	R:R:N342	6.87	No	Yes	2	9	9
41	R:R:T81	R:R:W162	3.64	No	Yes	0	6	9
42	R:R:D83	R:R:S124	5.89	Yes	No	0	9	9
43	R:R:D83	R:R:S339	7.36	Yes	No	0	9	9
44	R:R:D83	R:R:N342	8.08	Yes	Yes	2	9	9
45	R:R:L89	R:R:V85	4.47	No	No	0	5	7
46	R:R:C120	R:R:V85	3.42	No	No	0	6	7
47	R:R:V86	R:R:Y336	3.79	No	Yes	0	8	7
48	R:R:S339	R:R:V86	4.85	No	No	0	9	8
49	R:R:G87	R:R:V91	3.68	No	Yes	0	8	7
50	R:R:V90	R:R:W113	8.58	No	Yes	0	7	5
51	R:R:V90	R:R:Y336	3.79	No	Yes	0	7	7
52	R:R:P92	R:R:V91	3.53	No	Yes	0	8	7
53	R:R:V91	R:R:Y336	3.79	Yes	Yes	1	7	7
54	R:R:P92	R:R:P93	5.84	No	No	0	8	5
55	R:R:P93	R:R:W113	8.11	No	Yes	0	5	5
56	R:R:L97	R:R:W103	7.97	No	Yes	0	5	7
57	R:R:R102	R:R:T100	18.11	No	No	0	3	5
58	R:R:P104	R:R:W103	9.46	No	Yes	1	3	7
59	R:R:L105	R:R:W103	6.83	Yes	Yes	1	6	7
60	R:R:C110	R:R:W103	13.06	No	Yes	0	9	7
61	R:R:W103	R:R:W113	4.69	Yes	Yes	1	7	5
62	R:R:L105	R:R:P104	3.28	Yes	No	1	6	3
63	R:R:G109	R:R:L105	3.42	No	Yes	0	4	6
64	R:R:A107	R:R:N192	4.69	No	No	0	5	4
65	R:R:G109	R:R:T108	3.64	No	No	0	4	1
66	R:R:C110	R:R:C196	7.28	No	No	0	9	9
67	R:R:E111	R:R:I173	4.1	No	No	0	6	7
68	R:R:D117	R:R:W113	6.7	Yes	Yes	1	7	5
69	L:L:?1	R:R:W113	3.33	Yes	Yes	1	0	5
70	R:R:F198	R:R:T114	3.89	No	No	0	5	5
71	R:R:S115	R:R:S169	3.26	No	No	0	6	7
72	R:R:F170	R:R:S115	3.96	No	No	0	4	6
73	R:R:D117	R:R:V118	4.38	Yes	No	1	7	7
74	R:R:D117	R:R:Y336	3.45	Yes	Yes	1	7	7
75	L:L:?1	R:R:D117	17.87	Yes	Yes	1	0	7
76	R:R:S169	R:R:V118	6.46	No	No	0	7	7
77	L:L:?1	R:R:V118	5.45	Yes	No	1	0	7
78	R:R:V121	R:R:W305	9.81	No	Yes	1	7	8
79	L:L:?1	R:R:V121	7.63	Yes	No	1	0	7
80	R:R:T122	R:R:V168	4.76	No	No	0	7	6
81	R:R:S212	R:R:T122	9.59	No	No	0	6	7
82	R:R:A123	R:R:W162	7.78	No	Yes	0	8	9
83	R:R:A123	R:R:S165	3.42	No	No	0	8	8
84	R:R:I125	R:R:P216	3.39	No	Yes	0	8	9
85	R:R:F301	R:R:I125	3.77	Yes	No	1	9	8
86	R:R:I125	R:R:W305	3.52	No	Yes	1	8	8
87	R:R:E126	R:R:V161	4.28	No	No	0	5	7
88	R:R:E126	R:R:P216	4.72	No	Yes	0	5	9
89	R:R:L128	R:R:Y346	5.86	No	Yes	0	8	9
90	R:R:C129	R:R:P216	3.77	No	Yes	0	7	9
91	R:R:C129	R:R:V219	5.12	No	No	0	7	6
92	R:R:L131	R:R:Y346	5.86	No	Yes	0	8	9
93	R:R:A132	R:R:Y224	5.34	No	Yes	0	8	9
94	R:R:D134	R:R:Y145	5.75	No	Yes	0	9	7
95	R:R:R135	R:R:Y224	5.14	No	Yes	0	9	9
96	R:R:T140	R:R:Y136	13.73	No	Yes	0	6	8
97	R:R:V223	R:R:Y136	6.31	No	Yes	0	6	8
98	R:R:R226	R:R:Y136	11.32	No	Yes	0	6	8
99	R:R:A138	R:R:Y145	9.34	No	Yes	0	8	7
100	R:R:K151	R:R:R155	8.66	No	No	0	4	5
101	R:R:P172	R:R:Y204	9.74	No	Yes	0	7	8
102	R:R:E185	R:R:R188	15.12	Yes	No	1	2	2
103	R:R:A197	R:R:E185	4.53	No	Yes	0	4	2
104	R:R:A199	R:R:E185	4.53	No	Yes	0	4	2
105	L:L:?1	R:R:E185	4.85	Yes	Yes	1	0	2
106	R:R:C189	R:R:R188	12.54	No	No	1	1	2
107	L:L:?1	R:R:R188	8.89	Yes	No	1	0	2
108	R:R:C189	R:R:P193	5.65	No	No	1	1	2
109	R:R:C189	R:R:C195	7.28	No	No	1	1	4
110	R:R:C195	R:R:P193	7.53	No	No	1	4	2
111	L:L:?1	R:R:F198	24.95	Yes	No	0	0	5
112	R:R:A199	R:R:R315	4.15	No	No	0	4	4
113	R:R:N201	R:R:P203	9.77	No	No	0	6	4
114	R:R:N201	R:R:Y204	3.49	No	Yes	0	6	8
115	R:R:I202	R:R:P203	5.08	No	No	0	4	4
116	R:R:S208	R:R:Y204	3.82	No	Yes	0	6	8
117	L:L:?1	R:R:S208	3.3	Yes	No	0	0	6
118	R:R:S209	R:R:Y214	3.82	No	No	0	7	6
119	R:R:F309	R:R:S209	5.28	Yes	No	0	7	7
120	R:R:F309	R:R:S212	3.96	Yes	No	0	7	6
121	R:R:F213	R:R:Y214	5.16	Yes	No	0	8	6
122	R:R:F213	R:R:L217	6.09	Yes	No	0	8	6
123	R:R:F213	R:R:F301	5.36	Yes	Yes	0	8	9
124	R:R:F213	R:R:L306	4.87	Yes	No	0	8	6
125	R:R:F213	R:R:F309	17.15	Yes	Yes	0	8	7
126	R:R:L217	R:R:L221	4.15	No	No	0	6	5
127	R:R:M220	R:R:Y224	5.99	No	Yes	0	8	9
128	R:R:L294	R:R:Y224	3.52	No	Yes	0	8	9
129	R:R:F228	R:R:T232	7.78	Yes	No	0	6	5
130	R:R:F228	R:R:L294	3.65	Yes	No	0	6	8
131	R:R:F245	R:R:R244	5.34	No	No	0	1	5
132	R:R:F245	R:R:P246	4.33	No	No	0	1	3
133	R:R:R348	R:R:T293	3.88	No	No	0	7	8
134	R:R:I297	R:R:Y346	8.46	No	Yes	0	9	9
135	R:R:I345	R:R:T300	4.56	Yes	No	0	8	6
136	R:R:F301	R:R:W305	5.01	Yes	Yes	1	9	8
137	R:R:C304	R:R:N338	7.87	No	No	0	9	9
138	R:R:F308	R:R:W305	6.01	Yes	Yes	1	7	8
139	R:R:F309	R:R:W305	4.01	Yes	Yes	1	7	8
140	R:R:G335	R:R:W305	9.85	No	Yes	0	8	8
141	R:R:N338	R:R:W305	7.91	No	Yes	0	9	8
142	L:L:?1	R:R:W305	3.33	Yes	Yes	1	0	8
143	R:R:L306	R:R:P307	3.28	No	No	0	6	9
144	R:R:L331	R:R:P307	3.28	No	No	0	6	9
145	R:R:F308	R:R:N312	16.92	Yes	No	1	7	7
146	R:R:F308	R:R:L328	4.87	Yes	Yes	1	7	5
147	R:R:F308	R:R:L331	3.65	Yes	No	0	7	6
148	R:R:F308	R:R:N332	10.87	Yes	No	1	7	6
149	L:L:?1	R:R:F308	7.13	Yes	Yes	1	0	7
150	L:L:?1	R:R:F309	5.35	Yes	Yes	1	0	7
151	R:R:L328	R:R:N312	5.49	Yes	No	1	5	7
152	R:R:P320	R:R:R315	8.65	No	No	0	1	4
153	R:R:G318	R:R:L322	5.13	No	No	0	4	1
154	R:R:G319	R:R:P320	4.06	No	No	0	2	1
155	R:R:P324	R:R:V323	3.53	No	No	0	4	3
156	L:L:?1	R:R:S325	6.59	Yes	No	0	0	2
157	L:L:?1	R:R:L328	4.05	Yes	Yes	1	0	5
158	L:L:?1	R:R:L329	9.11	Yes	No	0	0	4
159	R:R:N332	R:R:Y336	19.77	No	Yes	1	6	7
160	L:L:?1	R:R:N332	15.07	Yes	No	1	0	6
161	L:L:?1	R:R:Y336	6	Yes	Yes	1	0	7
162	R:R:A337	R:R:F341	4.16	No	No	0	4	6
163	R:R:N338	R:R:N342	6.81	No	Yes	0	9	9
164	R:R:I345	R:R:N342	4.25	Yes	Yes	0	8	9
165	R:R:I345	R:R:Y346	8.46	Yes	Yes	0	8	9
166	R:R:C347	R:R:F352	15.36	No	Yes	0	7	8
167	R:R:F352	R:R:S349	5.28	Yes	No	0	8	8
168	R:R:A80	R:R:I59	3.25	No	No	0	9	7
169	R:R:S210	R:R:V211	3.23	No	No	0	4	4
170	R:R:F352	R:R:F356	3.22	Yes	No	0	8	7
171	R:R:T302	R:R:V298	3.17	No	No	0	6	8
172	R:R:A166	R:R:L119	3.15	No	No	0	4	5
173	R:R:I173	R:R:S115	3.1	No	No	0	7	6
174	R:R:I62	R:R:V76	3.07	Yes	No	0	7	8
175	R:R:K151	R:R:V74	3.04	No	No	0	4	5
176	R:R:M314	R:R:V310	3.04	No	No	0	4	6
177	R:R:L119	R:R:S165	3	No	No	0	5	8
178	R:R:L119	R:R:S169	3	No	No	0	5	7
179	R:R:L84	R:R:V52	2.98	No	Yes	0	8	5
180	R:R:L88	R:R:V52	2.98	No	Yes	0	4	5
181	R:R:L112	R:R:V116	2.98	No	No	0	5	6
182	R:R:L160	R:R:V164	2.98	No	No	0	3	5
183	R:R:L306	R:R:V310	2.98	No	No	0	6	6
184	R:R:L317	R:R:V313	2.98	No	No	0	4	6
185	R:R:I345	R:R:L296	2.85	Yes	No	0	8	7
186	R:R:G94	R:R:W113	2.81	No	Yes	0	7	5
187	R:R:L39	R:R:L43	2.77	No	No	0	4	5
188	R:R:L359	R:R:L57	2.77	Yes	No	3	5	7
189	R:R:A61	R:R:F356	2.77	No	No	0	8	7
190	R:R:A130	R:R:F75	2.77	No	Yes	0	7	8
191	R:R:A156	R:R:R152	2.77	No	No	0	2	5
192	R:R:A290	R:R:F228	2.77	No	Yes	0	8	6
193	R:R:A171	R:R:Y204	2.67	No	Yes	0	6	8
194	R:R:F222	R:R:V219	2.62	No	No	0	5	6
195	R:R:F222	R:R:V223	2.62	No	No	0	5	6
196	R:R:A82	R:R:W162	2.59	No	Yes	0	8	9
197	R:R:A95	R:R:W333	2.59	No	Yes	0	6	5
198	R:R:F341	R:R:T300	2.59	No	No	0	6	6
199	R:R:F301	R:R:T302	2.59	Yes	No	0	9	6
200	R:R:S200	R:R:Y204	2.54	No	Yes	0	4	8
201	R:R:V149	R:R:Y145	2.52	No	Yes	0	6	7
202	R:R:V313	R:R:Y214	2.52	No	No	0	6	6
203	R:R:F228	R:R:L291	2.44	Yes	No	0	6	8
204	R:R:L235	R:R:R239	2.43	No	No	0	5	5
205	R:R:L237	R:R:R240	2.43	No	No	0	5	4
206	R:R:I297	R:R:Y224	2.42	No	Yes	0	9	9
207	R:R:D351	R:R:R67	2.38	No	No	0	7	5
208	R:R:L137	R:R:Y136	2.34	No	Yes	0	5	8
209	R:R:E241	R:R:R244	2.33	No	No	0	2	5
210	R:R:L44	R:R:W333	2.28	No	Yes	0	8	5
211	R:R:R236	R:R:R239	2.13	No	No	0	6	5
212	R:R:G53	R:R:G54	2.11	No	No	0	4	8
213	R:R:G318	R:R:G319	2.11	No	No	0	4	2
214	R:R:A40	R:R:G41	1.95	No	No	0	4	6
215	R:R:P324	R:R:P326	1.95	No	No	0	4	1
216	R:R:A327	R:R:P324	1.87	No	No	0	4	4
217	R:R:G53	R:R:V52	1.84	No	Yes	0	4	5
218	R:R:G299	R:R:T302	1.82	No	No	0	5	6
219	R:R:A355	R:R:A61	1.79	No	No	0	8	8
220	R:R:A205	R:R:A316	1.79	No	No	0	6	6
221	R:R:A231	R:R:A290	1.79	No	No	0	8	8
222	R:R:P193	R:R:S191	1.78	No	No	0	2	1
223	R:R:P326	R:R:S325	1.78	No	No	0	1	2
224	R:R:P350	R:R:S349	1.78	No	No	0	5	8
225	R:R:G146	R:R:M71	1.75	No	No	0	6	6
226	R:R:P93	R:R:T96	1.75	No	No	0	5	5
227	R:R:C120	R:R:V86	1.71	No	No	0	6	8
228	R:R:G106	R:R:L105	1.71	No	Yes	0	7	6
229	R:R:C120	R:R:V116	1.71	No	No	0	6	6
230	R:R:C129	R:R:V133	1.71	No	No	0	7	6
231	R:R:G295	R:R:L294	1.71	No	No	0	6	8
232	R:R:G106	R:R:N192	1.7	No	No	0	7	4
233	R:R:L215	R:R:P216	1.64	No	Yes	0	5	9
234	R:R:N141	R:R:P142	1.63	No	No	0	5	8
235	R:R:A316	R:R:I202	1.62	No	No	0	6	4
236	R:R:V139	R:R:V230	1.6	No	No	0	9	6
237	R:R:V163	R:R:V164	1.6	No	No	0	4	5
238	R:R:V168	R:R:V211	1.6	No	No	5	6	4
239	R:R:T140	R:R:V139	1.59	No	No	0	6	9
240	R:R:C304	R:R:L334	1.59	No	No	0	9	7
241	R:R:A45	R:R:L44	1.58	No	No	0	3	8
242	R:R:P66	R:R:Q69	1.58	No	No	0	6	7
243	R:R:A98	R:R:L329	1.58	No	No	0	5	4
244	R:R:A311	R:R:L328	1.58	No	Yes	0	5	5
245	R:R:A311	R:R:L331	1.58	No	No	0	5	6
246	R:R:I297	R:R:T293	1.52	No	No	0	9	8
247	R:R:K151	R:R:T150	1.5	No	No	0	4	8
248	R:R:L322	R:R:S321	1.5	No	No	0	1	1
249	R:R:L49	R:R:V52	1.49	No	Yes	0	5	5
250	R:R:L207	R:R:V168	1.49	No	No	5	4	6
251	R:R:L206	R:R:V313	1.49	No	No	0	6	6
252	R:R:L207	R:R:V211	1.49	No	No	5	4	4
253	R:R:L99	R:R:T100	1.47	No	No	0	5	5
254	R:R:G146	R:R:Y145	1.45	No	Yes	0	6	7
255	R:R:E126	R:R:V164	1.43	No	No	0	5	5
256	R:R:I345	R:R:L344	1.43	Yes	No	0	8	6
257	R:R:A157	R:R:F75	1.39	No	Yes	0	6	8
258	R:R:L360	R:R:L57	1.38	No	No	3	7	7
259	R:R:L238	R:R:L242	1.38	No	No	0	4	4
260	R:R:L359	R:R:L360	1.38	Yes	No	3	5	7
261	R:R:L148	R:R:N141	1.37	No	No	0	5	5
262	R:R:R153	R:R:T150	1.29	No	No	0	7	8
263	R:R:R236	R:R:T232	1.29	No	No	0	6	5
264	R:R:H288	R:R:L291	1.29	No	No	0	5	8
265	R:R:R289	R:R:T293	1.29	No	No	0	8	8
266	R:R:V227	R:R:Y224	1.26	No	Yes	0	9	9
267	R:R:Q234	R:R:R233	1.17	No	No	0	7	5
268	R:R:E287	R:R:R289	1.16	No	No	0	8	8
269	R:R:L43	R:R:W333	1.14	No	Yes	0	5	5
270	R:R:R152	R:R:R155	1.07	No	No	0	5	5

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:V52	2.3225	4	0	5
2	R:R:I62	4.5775	4	4	7
3	R:R:T65	5.3475	4	0	6
4	R:R:F75	3.86714	7	0	8
5	R:R:D83	7.512	5	2	9
6	R:R:V91	4.5325	4	1	7
7	R:R:W103	8.402	5	1	7
8	R:R:L105	3.81	4	1	6
9	R:R:W113	5.70333	6	1	5
10	R:R:D117	8.1	4	1	7
11	R:R:Y136	8.425	4	0	8
12	R:R:Y145	4.765	4	0	7
13	R:R:W162	5.665	4	0	9
14	R:R:E185	7.2575	4	1	2
15	R:R:Y204	4.452	5	0	8
16	R:R:F213	7.726	5	0	8
17	R:R:P216	3.38	4	0	9
18	R:R:Y224	3.945	6	0	9
19	R:R:F228	4.16	4	0	6
20	R:R:F301	4.1825	4	1	9
21	R:R:W305	6.18125	8	1	8
22	R:R:F308	8.24167	6	1	7
23	R:R:F309	7.15	5	1	7
24	R:R:L328	3.9975	4	1	5
25	R:R:W333	5.5925	4	0	5
26	R:R:Y336	6.44	7	1	7
27	R:R:N342	6.5025	4	2	9
28	R:R:I345	4.31	5	0	8
29	R:R:Y346	7.16	4	0	9
30	R:R:F352	7.44167	6	4	8
31	R:R:L359	3.6725	4	3	5
32	L:L:?1	8.30625	16	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A40	R:R:G41	11.1881	1.95	No	No	0	4	6
2	R:R:G41	R:R:L44	14.0028	5.13	No	No	0	6	8
3	R:R:L44	R:R:W333	19.5757	2.28	No	Yes	0	8	5
4	R:R:E47	R:R:W333	30.4031	16.36	No	Yes	0	7	5
5	R:R:E47	R:R:Y336	32.4399	4.49	No	Yes	1	7	7
6	R:R:V86	R:R:Y336	36.5417	3.79	No	Yes	0	8	7
7	R:R:S339	R:R:V86	34.8444	4.85	No	No	0	9	8
8	R:R:D83	R:R:S339	34.7242	7.36	Yes	No	0	9	9
9	R:R:D83	R:R:N55	24.7525	6.73	Yes	No	0	9	9
10	R:R:L84	R:R:N55	19.3494	6.87	No	No	0	8	9
11	R:R:D83	R:R:L79	14.3281	9.5	Yes	No	2	9	9
12	R:R:L79	R:R:T127	18.9463	4.42	No	No	0	9	8
13	R:R:S78	R:R:T127	17.9986	4.8	No	No	0	9	8
14	R:R:S78	R:R:V158	19.7878	4.85	No	No	0	9	7
15	R:R:F75	R:R:V158	19.0453	3.93	Yes	No	0	8	7
16	R:R:D134	R:R:F75	67.3479	3.58	No	Yes	0	9	8
17	R:R:D134	R:R:T72	56.6407	11.56	No	No	0	9	8
18	R:R:T70	R:R:T72	54.802	4.71	No	No	0	8	8
19	R:R:N73	R:R:T70	52.9491	5.85	No	No	0	9	8
20	R:R:F352	R:R:N73	44.9222	8.46	Yes	No	4	8	9
21	R:R:F352	R:R:F356	17.1924	3.22	Yes	No	0	8	7
22	R:R:D83	R:R:N342	30.5799	8.08	Yes	Yes	2	9	9
23	R:R:I345	R:R:N342	100	4.25	Yes	Yes	0	8	9
24	R:R:I345	R:R:Y346	94.4837	8.46	Yes	Yes	0	8	9
25	R:R:L131	R:R:Y346	71.0184	5.86	No	Yes	0	8	9
26	R:R:F75	R:R:L131	69.8868	7.31	Yes	No	0	8	8
27	L:L:?1	R:R:Y336	37.0863	6	Yes	Yes	1	0	7
28	L:L:?1	R:R:W305	66.9873	3.33	Yes	Yes	1	0	8
29	R:R:N338	R:R:W305	96.0396	7.91	No	Yes	0	9	8
30	R:R:N338	R:R:N342	94.8727	6.81	No	Yes	0	9	9
31	R:R:F356	R:R:L57	10.785	12.18	No	No	0	7	7
32	R:R:F352	R:R:L68	15.2405	7.31	Yes	No	0	8	8
33	R:R:L68	R:R:T65	13.1047	8.84	No	Yes	0	8	6
34	R:R:F75	R:R:V74	15.2405	3.93	Yes	No	0	8	5
35	R:R:S169	R:R:V118	18.3027	6.46	No	No	0	7	7
36	R:R:L119	R:R:S169	11.4427	3	No	No	0	5	7
37	L:L:?1	R:R:V118	15.1202	5.45	Yes	No	1	0	7
38	R:R:C120	R:R:V86	11.5488	1.71	No	No	0	6	8
39	L:L:?1	R:R:W113	27.7935	3.33	Yes	Yes	1	0	5
40	R:R:W103	R:R:W113	25.2829	4.69	Yes	Yes	1	7	5
41	R:R:L105	R:R:W103	14.0382	6.83	Yes	Yes	1	6	7
42	L:L:?1	R:R:F309	15.3253	5.35	Yes	Yes	1	0	7
43	R:R:F309	R:R:S212	10.4173	3.96	Yes	No	0	7	6
44	R:R:I125	R:R:W305	28.0057	3.52	No	Yes	1	8	8
45	R:R:I125	R:R:P216	28.5431	3.39	No	Yes	0	8	9
46	R:R:F301	R:R:W305	13.0622	5.01	Yes	Yes	1	9	8
47	R:R:C129	R:R:P216	17.9986	3.77	No	Yes	0	7	9
48	R:R:C129	R:R:V219	14.8303	5.12	No	No	0	7	6
49	R:R:I297	R:R:Y224	29.4979	2.42	No	Yes	0	9	9
50	R:R:I297	R:R:Y346	38.0269	8.46	No	Yes	0	9	9
51	R:R:D134	R:R:Y145	10.9477	5.75	No	Yes	0	9	7
52	R:R:F222	R:R:V219	13.2249	2.62	No	No	0	5	6
53	R:R:F222	R:R:V223	11.6054	2.62	No	No	0	5	6
54	R:R:K151	R:R:V74	13.1047	3.04	No	No	0	4	5
55	L:L:?1	R:R:S208	17.0934	3.3	Yes	No	0	0	6
56	R:R:S208	R:R:Y204	15.587	3.82	No	Yes	0	6	8
57	L:L:?1	R:R:E185	15.2687	4.85	Yes	Yes	1	0	2
58	R:R:A199	R:R:E185	12.2207	4.53	No	Yes	0	4	2
59	R:R:A199	R:R:R315	10.5163	4.15	No	No	0	4	4
60	R:R:F213	R:R:F309	14.9717	17.15	Yes	Yes	0	8	7
61	R:R:L294	R:R:Y224	20.6223	3.52	No	Yes	0	8	9
62	R:R:F228	R:R:L294	16.9731	3.65	Yes	No	0	6	8
63	R:R:L84	R:R:V52	13.8897	2.98	No	Yes	0	8	5
64	R:R:V313	R:R:Y214	11.7185	2.52	No	No	0	6	6
65	R:R:V91	R:R:Y336	16.1315	3.79	Yes	Yes	1	7	7
66	R:R:F309	R:R:W305	17.157	4.01	Yes	Yes	1	7	8

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:E47	R:R:V91	7.13	1	No	Yes	7	7	2	2
R:R:E47	R:R:Y336	4.49	1	No	Yes	7	7	2	1
R:R:V86	R:R:Y336	3.79	0	No	Yes	8	7	2	1
R:R:V90	R:R:W113	8.58	0	No	Yes	7	5	2	1
R:R:V90	R:R:Y336	3.79	0	No	Yes	7	7	2	1
R:R:V91	R:R:Y336	3.79	1	Yes	Yes	7	7	2	1
R:R:P93	R:R:W113	8.11	0	No	Yes	5	5	2	1
R:R:W103	R:R:W113	4.69	1	Yes	Yes	7	5	2	1
R:R:D117	R:R:W113	6.7	1	Yes	Yes	7	5	1	1
L:L:?1	R:R:W113	3.33	1	Yes	Yes	0	5	0	1
R:R:F198	R:R:T114	3.89	0	No	No	5	5	1	2
R:R:D117	R:R:V118	4.38	1	Yes	No	7	7	1	1
R:R:D117	R:R:Y336	3.45	1	Yes	Yes	7	7	1	1
L:L:?1	R:R:D117	17.87	1	Yes	Yes	0	7	0	1
R:R:S169	R:R:V118	6.46	0	No	No	7	7	2	1
L:L:?1	R:R:V118	5.45	1	Yes	No	0	7	0	1
R:R:V121	R:R:W305	9.81	1	No	Yes	7	8	1	1
L:L:?1	R:R:V121	7.63	1	Yes	No	0	7	0	1
R:R:F301	R:R:I125	3.77	1	Yes	No	9	8	2	2
R:R:I125	R:R:W305	3.52	1	No	Yes	8	8	2	1
R:R:E185	R:R:R188	15.12	1	Yes	No	2	2	1	1
R:R:A197	R:R:E185	4.53	0	No	Yes	4	2	2	1
R:R:A199	R:R:E185	4.53	0	No	Yes	4	2	2	1
L:L:?1	R:R:E185	4.85	1	Yes	Yes	0	2	0	1
R:R:C189	R:R:R188	12.54	1	No	No	1	2	2	1
L:L:?1	R:R:R188	8.89	1	Yes	No	0	2	0	1
L:L:?1	R:R:F198	24.95	1	Yes	No	0	5	0	1
R:R:S208	R:R:Y204	3.82	0	No	Yes	6	8	1	2
L:L:?1	R:R:S208	3.3	1	Yes	No	0	6	0	1
R:R:F309	R:R:S209	5.28	1	Yes	No	7	7	1	2
R:R:F309	R:R:S212	3.96	1	Yes	No	7	6	1	2
R:R:F213	R:R:F301	5.36	0	Yes	Yes	8	9	2	2
R:R:F213	R:R:F309	17.15	0	Yes	Yes	8	7	2	1
R:R:F301	R:R:W305	5.01	1	Yes	Yes	9	8	2	1
R:R:F308	R:R:W305	6.01	1	Yes	Yes	7	8	1	1
R:R:F309	R:R:W305	4.01	1	Yes	Yes	7	8	1	1
R:R:G335	R:R:W305	9.85	0	No	Yes	8	8	2	1
R:R:N338	R:R:W305	7.91	0	No	Yes	9	8	2	1
L:L:?1	R:R:W305	3.33	1	Yes	Yes	0	8	0	1
R:R:F308	R:R:N312	16.92	1	Yes	No	7	7	1	2
R:R:F308	R:R:L328	4.87	1	Yes	Yes	7	5	1	1
R:R:F308	R:R:L331	3.65	1	Yes	No	7	6	1	2
R:R:F308	R:R:N332	10.87	1	Yes	No	7	6	1	1
L:L:?1	R:R:F308	7.13	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F309	5.35	1	Yes	Yes	0	7	0	1
R:R:L328	R:R:N312	5.49	1	Yes	No	5	7	1	2
L:L:?1	R:R:S325	6.59	1	Yes	No	0	2	0	1
L:L:?1	R:R:L328	4.05	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:L329	9.11	1	Yes	No	0	4	0	1
R:R:N332	R:R:Y336	19.77	1	No	Yes	6	7	1	1
L:L:?1	R:R:N332	15.07	1	Yes	No	0	6	0	1
L:L:?1	R:R:Y336	6	1	Yes	Yes	0	7	0	1
R:R:G94	R:R:W113	2.81	0	No	Yes	7	5	2	1
R:R:P326	R:R:S325	1.78	0	No	No	1	2	2	1
R:R:A98	R:R:L329	1.58	0	No	No	5	4	2	1
R:R:A311	R:R:L328	1.58	0	No	Yes	5	5	2	1
R:R:A311	R:R:L331	1.58	0	No	No	5	6	2	2

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XJI_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.26
Number of Linked Nodes	248
Number of Links	270
Number of Hubs	32
Number of Links mediated by Hubs	141
Number of Communities	5
Number of Nodes involved in Communities	36
Number of Links involved in Communities	50

Path Summary
Number Of Nodes in MetaPath	67
Number Of Links MetaPath	66
Number of Shortest Paths	36116
Length Of Smallest Path	3
Average Path Length	11.3062
Length of Longest Path	26
Minimum Path Strength	1.225
Average Path Strength	5.56699
Maximum Path Strength	21.41
Minimum Path Correlation	0.7
Average Path Correlation	0.934275
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.34783
Average % Of Corr. Nodes	61.9149
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	42.9045
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• binding • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • protein binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development
Gene Ontology	Biological Process	• developmental process • multicellular organismal process • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • animal organ development • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure development • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • cellular homeostasis • chemical homeostasis • homeostatic process • glucose homeostasis • carbohydrate homeostasis • intracellular chemical homeostasis • intracellular glucose homeostasis • system process • regulation of biological process • nervous system process • neuromuscular process • regulation of system process • biological regulation • skeletal muscle contraction • muscle contraction • muscle system process • regulation of muscle system process • striated muscle contraction • multicellular organismal movement • musculoskeletal movement • regulation of striated muscle contraction • regulation of muscle contraction • regulation of skeletal muscle contraction • regulation of multicellular organismal process • sensory perception of chemical stimulus • sensory perception • sensory perception of smell • cellular response to stimulus • cellular response to nitrogen compound • response to stimulus • response to endogenous stimulus • response to peptide hormone • cellular response to peptide hormone stimulus • response to oxygen-containing compound • response to nitrogen compound • response to glucagon • cellular response to oxygen-containing compound • cellular response to glucagon stimulus • cellular response to endogenous stimulus • cellular response to chemical stimulus • response to hormone • response to chemical • cellular process • cellular response to hormone stimulus • multicellular organism development • skeletal system development • bone development • system development • response to pH • cellular response to pH • response to abiotic stimulus • cellular response to acidic pH • response to acidic pH • cellular response to abiotic stimulus • cellular response to environmental stimulus • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • response to stress • coagulation • regulation of biological quality • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • response to ketone • response to prostaglandin • response to lipid • response to alcohol • cellular response to prostaglandin stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • cellular response to lipid • response to prostaglandin E • cellular response to ketone • regulation of cellular process • signaling • adenylate cyclase-activating G protein-coupled receptor signaling pathway • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • positive regulation of biological process • adaptive thermogenesis • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • positive regulation of cell communication • regulation of localization • establishment of protein localization • nitrogen compound transport • positive regulation of establishment of protein localization • localization • establishment of localization in cell • positive regulation of insulin secretion involved in cellular response to glucose stimulus • positive regulation of insulin secretion • intracellular protein localization • regulation of peptide hormone secretion • regulation of hormone levels • positive regulation of peptide hormone secretion • establishment of protein localization to extracellular region • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • cellular response to carbohydrate stimulus • response to glucose • positive regulation of protein localization • insulin secretion involved in cellular response to glucose stimulus • cellular localization • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • positive regulation of secretion by cell • hormone secretion • protein localization to extracellular region • positive regulation of protein transport • peptide secretion • regulation of secretion by cell • secretion by cell • positive regulation of hormone secretion • response to monosaccharide • response to carbohydrate • positive regulation of secretion • signal release • cellular response to hexose stimulus • cellular response to monosaccharide stimulus • positive regulation of cellular process • positive regulation of peptide secretion • regulation of signaling • regulation of transport • secretion • regulation of peptide transport • regulation of establishment of protein localization • export from cell • cell-cell signaling • cellular response to glucose stimulus • regulation of protein transport • positive regulation of protein secretion • peptide transport • response to hexose • positive regulation of transport • regulation of cellular localization • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • regulation of insulin secretion involved in cellular response to glucose stimulus • hormone transport • regulation of cell communication • insulin secretion • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adrenergic receptor signaling pathway • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • cellular response to catecholamine stimulus • serotonin receptor signaling pathway • cellular response to monoamine stimulus • adenylate cyclase-activating serotonin receptor signaling pathway • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • regulation of response to stimulus • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • adenylate cyclase-activating dopamine receptor signaling pathway • G protein-coupled dopamine receptor signaling pathway • cell surface receptor signaling pathway • bile acid signaling pathway • adenylate cyclase-activating G protein-coupled bile acid receptor signaling pathway • renal system process • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• cellular anatomical structure • membrane • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • extracellular exosome • membrane-bounded organelle • extracellular vesicle • extracellular organelle • extracellular region • organelle • extracellular space • vesicle • extracellular membrane-bounded organelle • intracellular anatomical structure • cytoplasm • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network • organelle membrane • identical protein binding • protein binding • binding • protein homodimerization activity • protein dimerization activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • neurotransmitter receptor activity • pyrophosphatase activity • GTPase activity • G protein activity • ribonucleoside triphosphate phosphatase activity • molecular function regulator activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • G protein-coupled serotonin receptor activity • beta3-adrenergic receptor activity • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • biological regulation • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • positive regulation of ERK1 and ERK2 cascade • ERK1 and ERK2 cascade • regulation of ERK1 and ERK2 cascade • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway • multicellular organismal process • system process • regulation of system process • negative regulation of biological process • muscle contraction • muscle system process • regulation of muscle system process • negative regulation of muscle contraction • smooth muscle contraction • regulation of smooth muscle contraction • regulation of muscle contraction • regulation of multicellular organismal process • negative regulation of smooth muscle contraction • negative regulation of multicellular organismal process • lipid catabolic process • catabolic process • regulation of lipid metabolic process • primary metabolic process • regulation of catabolic process • regulation of lipid catabolic process • regulation of primary metabolic process • positive regulation of catabolic process • positive regulation of metabolic process • positive regulation of lipid catabolic process • positive regulation of lipid metabolic process • metabolic process • regulation of metabolic process • lipid metabolic process • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • receptor complex • synapse • cell junction • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • G-protein beta-subunit binding • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • cell projection membrane • cell body
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	EI5
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	EI5
Name	3-[3-[2-[[(2~{S})-2-(3-chlorophenyl)-2-oxidanyl-ethyl]amino]ethylamino]phenyl]benzoic acid
Synonyms
Identifier
Formula	C23 H23 Cl N2 O3
Molecular Weight	410.893
SMILES
PubChem	67469417
Formal Charge	0
Total Atoms	52
Total Chiral Atoms	1
Total Bonds	54
Total Aromatic Bonds	18


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O02662
Sequence	>7XJI_nogp_Chain_R A V A L A G A L L A L E V L A T V G G N L L V I V A I A R T P R L Q T M T N V F V T S L A T A D L V V G L L V V P P G A T L A L T G R W P L G A T G C E L W T S V D V L C V T A S I E T L C A L A V D R Y L A V T N P L R Y G A L V T K R R A R A A V V L V W V V S A A V S F A P I M S E A Q R C H S N P H C C A F A S N I P Y A L L S S S V S F Y L P L L V M L F V Y A R V F L V A T R Q L R L L R R E L G R F P E H R A L R T L G L I V G T F T L C W L P F F V A N V M R A L G G P S L V P S P A L L A L N W L G Y A N S A F N P L I Y C R S P D F R S A F R R L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7DH5	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-	Gs/β1/γ2	3.16	2021-08-04	doi.org/10.1016/j.molcel.2021.06.024
	7DH5 (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-		3.16	2021-08-04	doi.org/10.1016/j.molcel.2021.06.024
	7XJH	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoprenaline	-	Gs/β1/γ2	3.3	2022-05-04	doi.org/10.1016/j.molcel.2021.06.024
	7XJH (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoprenaline	-		3.3	2022-05-04	doi.org/10.1016/j.molcel.2021.06.024
	7XJI	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-	Gs/β1/γ2	3.9	2022-05-04	doi.org/10.1016/j.bbrc.2022.04.065
	7XJI (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-		3.9	2022-05-04	doi.org/10.1016/j.bbrc.2022.04.065
	9IJD	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-	chim(NtGi1-Gs)/β1/γ2	2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJD (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-		2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJE	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-	chim(NtGi1-Gs)/β1/γ2	2.34	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJE (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-		2.34	2024-08-21	doi.org/10.1002/cplu.202400288

2D representation of the interactions of this orthosteric/allosteric ligand.

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

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