psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D117	17.89	Yes	Yes	1	0	8
2	L:L:?1	R:R:V118	15.43	Yes	No	0	0	7
3	L:L:?1	R:R:V121	11.22	Yes	No	0	0	6
4	L:L:?1	R:R:S208	4.24	Yes	No	0	0	6
5	L:L:?1	R:R:S212	4.24	Yes	Yes	0	0	6
6	L:L:?1	R:R:F308	11.47	Yes	Yes	1	0	7
7	L:L:?1	R:R:F309	9.17	Yes	Yes	1	0	7
8	L:L:?1	R:R:N332	10.34	Yes	No	1	0	7
9	R:R:A95	R:R:L44	4.73	No	No	0	6	7
10	R:R:L44	R:R:W333	3.42	No	No	0	7	6
11	R:R:V48	R:R:V91	3.21	No	Yes	1	6	8
12	R:R:P92	R:R:V48	3.53	No	No	1	8	6
13	R:R:N55	R:R:T51	4.39	Yes	No	0	9	7
14	R:R:S339	R:R:T51	6.4	No	No	0	9	7
15	R:R:G53	R:R:V52	3.68	No	Yes	0	3	6
16	R:R:L84	R:R:V52	4.47	No	Yes	0	7	6
17	R:R:A80	R:R:N55	3.13	No	Yes	0	9	9
18	R:R:D83	R:R:N55	13.46	Yes	Yes	0	9	9
19	R:R:N55	R:R:P343	4.89	Yes	No	0	9	9
20	R:R:F356	R:R:L57	8.53	No	No	0	8	8
21	R:R:L360	R:R:L57	4.15	No	No	0	6	8
22	R:R:A80	R:R:V58	3.39	No	No	0	9	9
23	R:R:C347	R:R:V58	6.83	No	No	0	7	9
24	R:R:A80	R:R:I59	3.25	No	No	0	9	7
25	R:R:V60	R:R:W64	3.68	No	No	0	4	5
26	R:R:I62	R:R:N73	8.5	Yes	Yes	2	8	9
27	R:R:F352	R:R:I62	5.02	Yes	Yes	2	9	8
28	R:R:P66	R:R:T65	3.5	No	No	0	6	6
29	R:R:L68	R:R:T65	8.84	No	No	0	8	6
30	R:R:R358	R:R:T65	3.88	No	No	0	5	6
31	R:R:D351	R:R:R67	25.01	No	No	0	7	5
32	R:R:L68	R:R:N73	4.12	No	Yes	2	8	9
33	R:R:F352	R:R:L68	12.18	Yes	No	2	9	8
34	R:R:N73	R:R:T70	5.85	Yes	No	0	9	7
35	R:R:D134	R:R:T72	8.67	No	No	0	9	8
36	R:R:F352	R:R:N73	7.25	Yes	Yes	2	9	9
37	R:R:A154	R:R:V74	5.09	No	No	0	7	5
38	R:R:A130	R:R:F75	4.16	No	Yes	0	7	8
39	R:R:D134	R:R:F75	5.97	No	Yes	0	9	8
40	R:R:S78	R:R:T127	7.99	No	No	0	9	8
41	R:R:S78	R:R:V158	4.85	No	No	0	9	7
42	R:R:S78	R:R:W162	6.18	No	Yes	0	9	9
43	R:R:L79	R:R:T127	4.42	Yes	No	0	9	8
44	R:R:L128	R:R:L79	5.54	No	Yes	3	9	9
45	R:R:L79	R:R:N342	12.36	Yes	No	0	9	9
46	R:R:L79	R:R:Y346	3.52	Yes	Yes	3	9	9
47	R:R:D83	R:R:S124	4.42	Yes	No	0	9	9
48	R:R:D83	R:R:S339	5.89	Yes	No	0	9	9
49	R:R:D83	R:R:N342	8.08	Yes	No	0	9	9
50	R:R:C120	R:R:V85	3.42	No	No	0	7	6
51	R:R:C120	R:R:M86	3.24	No	No	0	7	7
52	R:R:M86	R:R:Y336	3.59	No	Yes	0	7	8
53	R:R:V90	R:R:W113	3.68	No	No	1	7	6
54	R:R:D117	R:R:V90	4.38	Yes	No	1	8	7
55	R:R:V90	R:R:Y336	5.05	No	Yes	1	7	8
56	R:R:P92	R:R:V91	3.53	No	Yes	1	8	8
57	R:R:V91	R:R:Y336	3.79	Yes	Yes	1	8	8
58	R:R:P92	R:R:P93	5.84	No	No	0	8	6
59	R:R:P93	R:R:W103	10.81	No	Yes	0	6	8
60	R:R:P93	R:R:W113	8.11	No	No	0	6	6
61	R:R:A94	R:R:W333	5.19	No	No	0	6	6
62	R:R:T100	R:R:T96	3.14	No	No	0	5	4
63	R:R:T96	R:R:W103	3.64	No	Yes	4	4	8
64	R:R:P104	R:R:T96	3.5	No	No	4	3	4
65	R:R:P104	R:R:W103	13.51	No	Yes	4	3	8
66	R:R:L105	R:R:W103	19.36	No	Yes	0	5	8
67	R:R:G109	R:R:L105	5.13	No	No	0	5	5
68	R:R:D117	R:R:W113	3.35	Yes	No	1	8	6
69	R:R:F170	R:R:S115	6.61	No	No	0	5	6
70	R:R:I173	R:R:S115	4.64	No	No	0	6	6
71	R:R:D117	R:R:Y336	10.34	Yes	Yes	1	8	8
72	R:R:S169	R:R:V118	3.23	No	No	0	8	7
73	R:R:L119	R:R:W162	3.42	No	Yes	0	6	9
74	R:R:L119	R:R:S169	6.01	No	No	0	6	8
75	R:R:V121	R:R:W305	9.81	No	Yes	0	6	8
76	R:R:S165	R:R:T122	3.2	No	No	0	8	7
77	R:R:S212	R:R:T122	7.99	Yes	No	0	6	7
78	R:R:A123	R:R:W162	7.78	No	Yes	0	8	9
79	R:R:A123	R:R:S165	3.42	No	No	0	8	8
80	R:R:I125	R:R:P216	3.39	No	Yes	0	8	9
81	R:R:F301	R:R:I125	6.28	Yes	No	0	9	8
82	R:R:I125	R:R:W305	3.52	No	Yes	0	8	8
83	R:R:C129	R:R:W126	5.22	Yes	No	5	7	6
84	R:R:V161	R:R:W126	3.68	No	No	0	7	6
85	R:R:P216	R:R:W126	14.86	Yes	No	5	9	6
86	R:R:F301	R:R:L128	4.87	Yes	No	0	9	9
87	R:R:L128	R:R:Y346	5.86	No	Yes	3	9	9
88	R:R:C129	R:R:P216	3.77	Yes	Yes	5	7	9
89	R:R:C129	R:R:V219	5.12	Yes	No	0	7	6
90	R:R:C129	R:R:M220	4.86	Yes	No	0	7	8
91	R:R:L131	R:R:Y346	4.69	No	Yes	0	9	9
92	R:R:A132	R:R:M220	3.22	No	No	0	9	8
93	R:R:A132	R:R:Y224	6.67	No	Yes	0	9	9
94	R:R:D134	R:R:Y145	9.2	No	Yes	0	9	8
95	R:R:R135	R:R:Y346	4.12	No	Yes	0	9	9
96	R:R:L137	R:R:Y136	3.52	No	Yes	0	5	8
97	R:R:T140	R:R:Y136	14.98	No	Yes	0	6	8
98	R:R:V223	R:R:Y136	8.83	No	Yes	0	7	8
99	R:R:A138	R:R:Y145	8.01	No	Yes	0	8	8
100	R:R:V139	R:R:V230	3.21	No	No	0	9	7
101	R:R:L148	R:R:N141	4.12	No	No	0	5	6
102	R:R:L148	R:R:R144	3.64	No	No	0	5	6
103	R:R:V149	R:R:Y145	8.83	No	Yes	0	7	8
104	R:R:R152	R:R:R155	10.66	No	No	0	4	4
105	R:R:R152	R:R:T156	5.17	No	No	0	4	3
106	R:R:F170	R:R:S169	3.96	No	No	0	5	8
107	R:R:P172	R:R:Y204	12.52	No	No	0	9	8
108	R:R:M202	R:R:P203	6.71	Yes	No	0	4	3
109	R:R:L206	R:R:M202	5.65	No	Yes	6	5	4
110	R:R:A316	R:R:M202	3.22	No	Yes	6	6	4
111	R:R:S208	R:R:Y204	13.99	No	No	0	6	8
112	R:R:N312	R:R:V205	4.43	No	No	0	7	6
113	R:R:A316	R:R:V205	3.39	No	No	0	6	6
114	R:R:A316	R:R:L206	3.15	No	No	6	6	5
115	R:R:S209	R:R:Y214	6.36	No	No	1	6	5
116	R:R:F309	R:R:S209	7.93	Yes	No	1	7	6
117	R:R:S209	R:R:V313	3.23	No	No	1	6	5
118	R:R:F213	R:R:Y214	8.25	Yes	No	0	8	5
119	R:R:F213	R:R:L217	4.87	Yes	No	0	8	5
120	R:R:F213	R:R:F301	6.43	Yes	Yes	0	8	9
121	R:R:F213	R:R:L306	4.87	Yes	Yes	0	8	7
122	R:R:F213	R:R:F309	22.51	Yes	Yes	0	8	7
123	R:R:V313	R:R:Y214	5.05	No	No	1	5	5
124	R:R:L217	R:R:L221	4.15	No	No	0	5	5
125	R:R:F301	R:R:M220	7.46	Yes	No	0	9	8
126	R:R:F222	R:R:R226	13.9	No	No	0	4	6
127	R:R:L294	R:R:Y224	3.52	No	Yes	0	8	9
128	R:R:I297	R:R:Y224	6.04	No	Yes	0	8	9
129	R:R:M298	R:R:Y224	5.99	No	Yes	0	8	9
130	R:R:F228	R:R:T232	7.78	No	No	0	6	5
131	R:R:F228	R:R:L291	3.65	No	No	0	6	7
132	R:R:F228	R:R:L294	3.65	No	No	0	6	8
133	R:R:R233	R:R:V230	7.85	No	No	0	4	7
134	R:R:R233	R:R:R236	3.2	No	No	0	4	5
135	R:R:L235	R:R:R239	6.07	No	No	0	6	4
136	R:R:L238	R:R:L242	5.54	No	No	0	6	3
137	R:R:F245	R:R:R244	13.9	No	No	0	2	4
138	R:R:L291	R:R:R289	4.86	No	No	0	7	8
139	R:R:L296	R:R:R348	3.64	No	No	0	7	7
140	R:R:F341	R:R:T300	3.89	No	No	0	5	6
141	R:R:I345	R:R:T300	6.08	No	No	0	8	6
142	R:R:L306	R:R:T302	4.42	Yes	No	0	7	6
143	R:R:C304	R:R:N338	11.02	No	No	0	8	9
144	R:R:F308	R:R:W305	7.02	Yes	Yes	1	7	8
145	R:R:F309	R:R:W305	7.02	Yes	Yes	1	7	8
146	R:R:G335	R:R:W305	8.44	No	Yes	0	7	8
147	R:R:N338	R:R:W305	6.78	No	Yes	0	9	8
148	R:R:L306	R:R:P307	3.28	Yes	No	0	7	9
149	R:R:L306	R:R:L310	5.54	Yes	No	0	7	6
150	R:R:L331	R:R:P307	4.93	No	No	0	6	9
151	R:R:F308	R:R:F309	7.5	Yes	Yes	1	7	7
152	R:R:F308	R:R:F328	8.57	Yes	Yes	0	7	5
153	R:R:F308	R:R:N332	6.04	Yes	No	1	7	7
154	R:R:F328	R:R:N312	7.25	Yes	No	0	5	7
155	R:R:P320	R:R:R315	7.21	No	No	0	2	5
156	R:R:F328	R:R:R315	18.17	Yes	No	0	5	5
157	R:R:G319	R:R:P320	4.06	No	No	0	1	2
158	R:R:P324	R:R:V323	3.53	No	No	0	4	4
159	R:R:G325	R:R:P326	4.06	No	No	0	2	2
160	R:R:N332	R:R:Y336	17.44	No	Yes	1	7	8
161	R:R:W333	R:R:Y336	5.79	No	Yes	0	6	8
162	R:R:N338	R:R:N342	5.45	No	No	0	9	9
163	R:R:I345	R:R:Y346	9.67	No	Yes	0	8	9
164	R:R:C347	R:R:F352	15.36	No	Yes	0	7	9
165	R:R:F352	R:R:S349	7.93	Yes	No	0	9	9
166	R:R:F352	R:R:F356	4.29	Yes	No	0	9	8
167	R:R:R226	R:R:Y136	3.09	No	Yes	0	6	8
168	R:R:I62	R:R:V76	3.07	Yes	No	0	8	8
169	R:R:I62	R:R:T77	3.04	Yes	No	0	8	6
170	R:R:C110	R:R:E111	3.04	No	No	0	9	6
171	R:R:L88	R:R:V52	2.98	No	Yes	0	5	6
172	R:R:L137	R:R:V133	2.98	No	No	0	5	6
173	R:R:L296	R:R:T300	2.95	No	No	0	7	6
174	R:R:N141	R:R:T140	2.92	No	No	0	6	6
175	R:R:K151	R:R:M71	2.88	No	No	0	4	6
176	R:R:L317	R:R:M202	2.83	No	Yes	0	5	4
177	R:R:C292	R:R:R289	2.79	No	No	0	7	8
178	R:R:L56	R:R:L84	2.77	No	No	0	4	7
179	R:R:L359	R:R:L57	2.77	No	No	0	6	8
180	R:R:A61	R:R:F356	2.77	No	No	0	7	8
181	R:R:A166	R:R:F170	2.77	No	No	0	3	5
182	R:R:A337	R:R:F341	2.77	No	No	0	5	5
183	R:R:E241	R:R:L238	2.65	No	No	0	4	6
184	R:R:R67	R:R:S354	2.64	No	No	0	5	5
185	R:R:R358	R:R:S354	2.64	No	No	0	5	5
186	R:R:F75	R:R:V158	2.62	Yes	No	0	8	7
187	R:R:A63	R:R:W64	2.59	No	No	0	3	5
188	R:R:A82	R:R:W162	2.59	No	Yes	0	8	9
189	R:R:V227	R:R:Y136	2.52	No	Yes	0	9	8
190	R:R:V223	R:R:Y224	2.52	No	Yes	0	7	9
191	R:R:K151	R:R:R155	2.48	No	No	0	4	4
192	R:R:F328	R:R:L329	2.44	Yes	No	0	5	4
193	R:R:G53	R:R:G54	2.11	No	No	0	3	8
194	R:R:G318	R:R:G319	2.11	No	No	0	4	1
195	R:R:G54	R:R:P343	2.03	No	No	0	8	9
196	R:R:G325	R:R:P324	2.03	No	No	0	2	4
197	R:R:A171	R:R:P172	1.87	No	No	0	4	9
198	R:R:A327	R:R:P324	1.87	No	No	0	5	4
199	R:R:G87	R:R:V52	1.84	No	Yes	0	7	6
200	R:R:G87	R:R:V91	1.84	No	Yes	0	7	8
201	R:R:G101	R:R:T100	1.82	No	No	0	4	5
202	R:R:G109	R:R:T108	1.82	No	No	0	5	3
203	R:R:G299	R:R:T302	1.82	No	No	0	6	6
204	R:R:A355	R:R:A61	1.79	No	No	0	8	7
205	R:R:A231	R:R:A290	1.79	No	No	0	8	8
206	R:R:P350	R:R:S349	1.78	No	No	0	6	9
207	R:R:G106	R:R:L105	1.71	No	No	0	7	5
208	R:R:C120	R:R:V116	1.71	No	No	0	7	5
209	R:R:C110	R:R:T114	1.69	No	No	0	9	5
210	R:R:C153	R:R:T150	1.69	No	No	0	6	8
211	R:R:A340	R:R:T51	1.68	No	No	0	6	7
212	R:R:L215	R:R:P216	1.64	No	Yes	0	6	9
213	R:R:L334	R:R:P307	1.64	No	No	0	7	9
214	R:R:N141	R:R:P142	1.63	No	No	0	6	9
215	R:R:A81	R:R:I59	1.62	No	No	0	5	7
216	R:R:S208	R:R:V168	1.62	No	No	0	6	6
217	R:R:S212	R:R:V168	1.62	Yes	No	0	6	6
218	R:R:S212	R:R:V211	1.62	Yes	No	0	6	4
219	R:R:A154	R:R:M71	1.61	No	No	0	7	6
220	R:R:V158	R:R:V74	1.6	No	No	0	7	5
221	R:R:V139	R:R:V227	1.6	No	No	0	9	9
222	R:R:V159	R:R:V163	1.6	No	No	0	3	4
223	R:R:T114	R:R:V118	1.59	No	No	0	5	7
224	R:R:A45	R:R:L49	1.58	No	No	0	4	5
225	R:R:P66	R:R:Q69	1.58	No	No	0	6	8
226	R:R:A311	R:R:L331	1.58	No	No	0	5	6
227	R:R:M174	R:R:S175	1.53	No	No	0	5	6
228	R:R:I297	R:R:T293	1.52	No	No	0	8	9
229	R:R:L215	R:R:S210	1.5	No	No	0	6	5
230	R:R:L359	R:R:V60	1.49	No	No	0	6	4
231	R:R:L89	R:R:V85	1.49	No	No	0	5	6
232	R:R:L160	R:R:V164	1.49	No	No	0	2	5
233	R:R:G146	R:R:Y145	1.45	No	Yes	0	5	8
234	R:R:A157	R:R:F75	1.39	No	Yes	0	6	8
235	R:R:L314	R:R:L322	1.38	No	No	0	5	4
236	R:R:L237	R:R:Q234	1.33	No	No	0	5	7
237	R:R:R315	R:R:V323	1.31	No	No	0	5	4
238	R:R:F341	R:R:L344	1.22	No	No	0	5	7
239	R:R:L235	R:R:R289	1.21	No	No	0	6	8
240	R:R:Q234	R:R:R233	1.17	No	No	0	7	4
241	R:R:L97	R:R:W103	1.14	No	Yes	0	4	8
242	R:R:R348	R:R:R353	1.07	No	No	0	7	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	10.5	8	1	0
2	R:R:V52	3.2425	4	0	6
3	R:R:N55	6.4675	4	0	9
4	R:R:I62	4.9075	4	2	8
5	R:R:N73	6.43	4	2	9
6	R:R:F75	3.535	4	0	8
7	R:R:L79	6.46	4	3	9
8	R:R:D83	7.9625	4	0	9
9	R:R:V91	3.0925	4	1	8
10	R:R:W103	9.692	5	4	8
11	R:R:D117	8.99	4	1	8
12	R:R:C129	4.7425	4	5	7
13	R:R:Y136	6.588	5	0	8
14	R:R:Y145	6.8725	4	0	8
15	R:R:W162	4.9925	4	0	9
16	R:R:M202	4.6025	4	6	4
17	R:R:S212	3.8675	4	0	6
18	R:R:F213	9.386	5	0	8
19	R:R:P216	5.915	4	5	9
20	R:R:Y224	4.948	5	0	9
21	R:R:F301	6.26	4	0	9
22	R:R:W305	7.09833	6	1	8
23	R:R:L306	4.5275	4	0	7
24	R:R:F308	8.12	5	1	7
25	R:R:F309	10.826	5	1	7
26	R:R:F328	9.1075	4	0	5
27	R:R:Y336	7.66667	6	1	8
28	R:R:Y346	5.572	5	3	9
29	R:R:F352	8.67167	6	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D117	53.0909	17.89	Yes	Yes	1	0	8
2	R:R:D117	R:R:Y336	21.5967	10.34	Yes	Yes	1	8	8
3	R:R:W333	R:R:Y336	21.0449	5.79	No	Yes	0	6	8
4	R:R:L44	R:R:W333	10.5506	3.42	No	No	0	7	6
5	L:L:?1	R:R:N332	20.7409	10.34	Yes	No	1	0	7
6	R:R:N332	R:R:Y336	54.5772	17.44	No	Yes	1	7	8
7	R:R:V91	R:R:Y336	36.9215	3.79	Yes	Yes	1	8	8
8	R:R:D117	R:R:W113	28.5666	3.35	Yes	No	1	8	6
9	R:R:P93	R:R:W113	27.069	8.11	No	No	0	6	6
10	R:R:P92	R:R:V91	11.3951	3.53	No	Yes	1	8	8
11	L:L:?1	R:R:V121	17.0589	11.22	Yes	No	0	0	6
12	R:R:V121	R:R:W305	17.5881	9.81	No	Yes	0	6	8
13	R:R:N338	R:R:W305	74.316	6.78	No	Yes	0	9	8
14	R:R:N338	R:R:N342	71.5685	5.45	No	No	0	9	9
15	R:R:D83	R:R:N342	100	8.08	Yes	No	0	9	9
16	R:R:D83	R:R:N55	88.0869	13.46	Yes	Yes	0	9	9
17	L:L:?1	R:R:F308	27.5419	11.47	Yes	Yes	1	0	7
18	R:R:F308	R:R:W305	62.842	7.02	Yes	Yes	1	7	8
19	L:L:?1	R:R:F309	66.0061	9.17	Yes	Yes	1	0	7
20	R:R:F309	R:R:W305	24.7269	7.02	Yes	Yes	1	7	8
21	R:R:G87	R:R:V91	29.9628	1.84	No	Yes	0	7	8
22	R:R:G87	R:R:V52	26.2358	1.84	No	Yes	0	7	6
23	R:R:G53	R:R:V52	16.4621	3.68	No	Yes	0	3	6
24	R:R:A80	R:R:N55	86.4655	3.13	No	Yes	0	9	9
25	R:R:N55	R:R:P343	19.1195	4.89	Yes	No	0	9	9
26	R:R:A80	R:R:V58	78.7299	3.39	No	No	0	9	9
27	R:R:C347	R:R:V58	76.1063	6.83	No	No	0	7	9
28	R:R:C347	R:R:F352	73.4602	15.36	No	Yes	0	7	9
29	R:R:F352	R:R:F356	28.0374	4.29	Yes	No	0	9	8
30	R:R:F356	R:R:L57	18.8605	8.53	No	No	0	8	8
31	R:R:L359	R:R:L57	12.6562	2.77	No	No	0	6	8
32	R:R:F352	R:R:L68	24.8508	12.18	Yes	No	2	9	8
33	R:R:L68	R:R:T65	22.216	8.84	No	No	0	8	6
34	R:R:R358	R:R:T65	12.8139	3.88	No	No	0	5	6
35	L:L:?1	R:R:V118	48.5981	15.43	Yes	No	0	0	7
36	R:R:S169	R:R:V118	36.3923	3.23	No	No	0	8	7
37	R:R:L119	R:R:S169	23.95	6.01	No	No	0	6	8
38	R:R:L119	R:R:W162	23.2294	3.42	No	Yes	0	6	9
39	R:R:S78	R:R:W162	26.7312	6.18	No	Yes	0	9	9
40	R:R:S78	R:R:V158	44.736	4.85	No	No	0	9	7
41	R:R:F75	R:R:V158	24.3779	2.62	Yes	No	0	8	7
42	R:R:D134	R:R:F75	16.372	5.97	No	Yes	0	9	8
43	R:R:V158	R:R:V74	19.2996	1.6	No	No	0	7	5
44	R:R:A154	R:R:V74	16.6085	5.09	No	No	0	7	5
45	R:R:S78	R:R:T127	38.2502	7.99	No	No	0	9	8
46	R:R:L79	R:R:N342	56.0522	12.36	Yes	No	0	9	9
47	R:R:L79	R:R:T127	40.2995	4.42	Yes	No	0	9	8
48	R:R:F213	R:R:F309	78.3245	22.51	Yes	Yes	0	8	7
49	R:R:F213	R:R:F301	73.4264	6.43	Yes	Yes	0	8	9
50	R:R:F301	R:R:L128	63.056	4.87	Yes	No	0	9	9
51	R:R:L128	R:R:L79	38.8808	5.54	No	Yes	3	9	9
52	R:R:L128	R:R:Y346	22.9929	5.86	No	Yes	3	9	9
53	R:R:M86	R:R:Y336	26.7312	3.59	No	Yes	0	7	8
54	R:R:C120	R:R:M86	21.5967	3.24	No	No	0	7	7
55	R:R:C120	R:R:V85	10.956	3.42	No	No	0	7	6
56	R:R:P93	R:R:W103	29.7151	10.81	No	Yes	0	6	8
57	R:R:L105	R:R:W103	12.1495	19.36	No	Yes	0	5	8
58	R:R:F170	R:R:S169	16.9238	3.96	No	No	0	5	8
59	L:L:?1	R:R:S212	16.8337	4.24	Yes	Yes	0	0	6
60	R:R:I125	R:R:W305	38.5542	3.52	No	Yes	0	8	8
61	R:R:I125	R:R:P216	18.3425	3.39	No	Yes	0	8	9
62	R:R:F301	R:R:M220	93.6944	7.46	Yes	No	0	9	8
63	R:R:A132	R:R:M220	89.6408	3.22	No	No	0	9	8
64	R:R:A132	R:R:Y224	87.0735	6.67	No	Yes	0	9	9
65	R:R:D134	R:R:Y145	11.1587	9.2	No	Yes	0	9	8
66	R:R:V223	R:R:Y224	54.915	2.52	No	Yes	0	7	9
67	R:R:V223	R:R:Y136	52.0549	8.83	No	Yes	0	7	8
68	R:R:T140	R:R:Y136	15.9779	14.98	No	Yes	0	6	8
69	R:R:V227	R:R:Y136	22.216	2.52	No	Yes	0	9	8
70	R:R:V139	R:R:V227	19.0969	1.6	No	No	0	9	9
71	R:R:V139	R:R:V230	15.9667	3.21	No	No	0	9	7
72	R:R:N141	R:R:T140	12.8251	2.92	No	No	0	6	6
73	R:R:A154	R:R:M71	13.8948	1.61	No	No	0	7	6
74	R:R:K151	R:R:M71	11.1587	2.88	No	No	0	4	6
75	L:L:?1	R:R:S208	18.016	4.24	Yes	No	0	0	6
76	R:R:S208	R:R:Y204	11.4402	13.99	No	No	0	6	8
77	R:R:F308	R:R:F328	54.4083	8.57	Yes	Yes	0	7	5
78	R:R:F328	R:R:N312	22.1934	7.25	Yes	No	0	5	7
79	R:R:N312	R:R:V205	19.1082	4.43	No	No	0	7	6
80	R:R:A316	R:R:V205	15.9779	3.39	No	No	0	6	6
81	R:R:F213	R:R:L306	26.1119	4.87	Yes	Yes	0	8	7
82	R:R:L294	R:R:Y224	24.8958	3.52	No	Yes	0	8	9
83	R:R:F228	R:R:L294	21.8106	3.65	No	No	0	6	8
84	R:R:F228	R:R:L291	15.5726	3.65	No	No	0	6	7
85	R:R:R233	R:R:V230	12.8251	7.85	No	No	0	4	7
86	R:R:L291	R:R:R289	12.4198	4.86	No	No	0	7	8
87	R:R:I345	R:R:Y346	27.8234	9.67	No	Yes	0	8	9
88	R:R:I345	R:R:T300	24.4229	6.08	No	No	0	8	6
89	R:R:L296	R:R:T300	10.5957	2.95	No	No	0	7	6
90	R:R:F341	R:R:T300	10.5957	3.89	No	No	0	5	6
91	R:R:L306	R:R:P307	13.2305	3.28	Yes	No	0	7	9
92	R:R:F328	R:R:R315	28.0599	18.17	Yes	No	0	5	5
93	R:R:R315	R:R:V323	15.9779	1.31	No	No	0	5	4
94	R:R:P324	R:R:V323	12.8251	3.53	No	No	0	4	4
95	R:R:T114	R:R:V118	11.215	1.59	No	No	0	5	7
96	R:R:G53	R:R:G54	16.0568	2.11	No	No	0	3	8
97	R:R:G54	R:R:P343	16.9125	2.03	No	No	0	8	9
98	R:R:F301	R:R:I125	24.4792	6.28	Yes	No	0	9	8
99	R:R:L79	R:R:Y346	14.3903	3.52	Yes	Yes	3	9	9
100	R:R:F308	R:R:N332	36.5499	6.04	Yes	No	1	7	7
101	R:R:F308	R:R:F309	25.5489	7.5	Yes	Yes	1	7	7

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D117	17.89	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V118	15.43	1	Yes	No	0	7	0	1
L:L:?1	R:R:V121	11.22	1	Yes	No	0	6	0	1
L:L:?1	R:R:S208	4.24	1	Yes	No	0	6	0	1
L:L:?1	R:R:S212	4.24	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:F308	11.47	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F309	9.17	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N332	10.34	1	Yes	No	0	7	0	1
R:R:V90	R:R:W113	3.68	1	No	No	7	6	2	2
R:R:D117	R:R:V90	4.38	1	Yes	No	8	7	1	2
R:R:V90	R:R:Y336	5.05	1	No	Yes	7	8	2	2
R:R:D117	R:R:W113	3.35	1	Yes	No	8	6	1	2
R:R:D117	R:R:Y336	10.34	1	Yes	Yes	8	8	1	2
R:R:S169	R:R:V118	3.23	0	No	No	8	7	2	1
R:R:V121	R:R:W305	9.81	0	No	Yes	6	8	1	2
R:R:S212	R:R:T122	7.99	0	Yes	No	6	7	1	2
R:R:S208	R:R:Y204	13.99	0	No	No	6	8	1	2
R:R:F309	R:R:S209	7.93	1	Yes	No	7	6	1	2
R:R:F213	R:R:F309	22.51	0	Yes	Yes	8	7	2	1
R:R:F308	R:R:W305	7.02	1	Yes	Yes	7	8	1	2
R:R:F309	R:R:W305	7.02	1	Yes	Yes	7	8	1	2
R:R:F308	R:R:F309	7.5	1	Yes	Yes	7	7	1	1
R:R:F308	R:R:F328	8.57	1	Yes	Yes	7	5	1	2
R:R:F308	R:R:N332	6.04	1	Yes	No	7	7	1	1
R:R:N332	R:R:Y336	17.44	1	No	Yes	7	8	1	2
R:R:S208	R:R:V168	1.62	0	No	No	6	6	1	2
R:R:S212	R:R:V168	1.62	0	Yes	No	6	6	1	2
R:R:S212	R:R:V211	1.62	0	Yes	No	6	4	1	2
R:R:T114	R:R:V118	1.59	0	No	No	5	7	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IJE_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.13
Number of Linked Nodes	227
Number of Links	242
Number of Hubs	29
Number of Links mediated by Hubs	114
Number of Communities	6
Number of Nodes involved in Communities	31
Number of Links involved in Communities	39

Path Summary
Number Of Nodes in MetaPath	102
Number Of Links MetaPath	101
Number of Shortest Paths	32019
Length Of Smallest Path	3
Average Path Length	11.7521
Length of Longest Path	27
Minimum Path Strength	1.25
Average Path Strength	6.93178
Maximum Path Strength	16.5233
Minimum Path Correlation	0.7
Average Path Correlation	0.92376
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	5.55556
Average % Of Corr. Nodes	52.3169
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	40.7492
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • beta-3 adrenergic receptor binding • protein binding • binding • adrenergic receptor binding • signaling receptor binding • G protein-coupled receptor binding • beta3-adrenergic receptor activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • epinephrine binding • hormone binding • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • carbohydrate metabolic process • primary metabolic process • behavior • eating behavior • feeding behavior • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • generation of precursor metabolites and energy • energy derivation by oxidation of organic compounds • energy reserve metabolic process • developmental process • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • regulation of developmental process • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • regulation of multicellular organismal process • negative regulation of multicellular organismal process • positive regulation of biological process • positive regulation of metabolic process • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • system process • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • heat generation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • receptor complex • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • molecular function regulator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • insulin-like growth factor receptor binding • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • G-protein beta-subunit binding • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	ALE
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	ALE
Name	Epinephrine
Synonyms	Adrenaline
Identifier
Formula	C9 H13 N O3
Molecular Weight	183.204
SMILES
PubChem	139148732
Formal Charge	0
Total Atoms	26
Total Chiral Atoms	1
Total Bonds	26
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P13945
Sequence	>9IJE_nogp_Chain_R A L L A L A V L A T V G G N L L V I V A I A W T P R L Q T M T N V F V T S L A A A D L V M G L L V V P P A A T L A L T G H W P L G A T G C E L W T S V D V L C V T A S I W T L C A L A V D R Y L A V T N P L R Y G A L V T K R C A R T A V V L V W V V S A A V S F A P I M S M P Y V L L S S S V S F Y L P L L V M L F V Y A R V F V V A T R Q L R L L R G E L G R F R A L C T L G L I M G T F T L C W L P F F L A N V L R A L G G P S L V P G P A F L A L N W L G Y A N S A F N P L I Y C R S P D F R S A F R R L L C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XJI	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-	Gs/β1/γ2	3.9	2022-05-04	doi.org/10.1016/j.bbrc.2022.04.065
	7XJI (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-		3.9	2022-05-04	doi.org/10.1016/j.bbrc.2022.04.065
	7DH5	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-	Gs/β1/γ2	3.16	2021-08-04	doi.org/10.1016/j.molcel.2021.06.024
	7DH5 (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-		3.16	2021-08-04	doi.org/10.1016/j.molcel.2021.06.024
	7XJH	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoproterenol	-	Gs/β1/γ2	3.3	2022-05-04	doi.org/10.1016/j.molcel.2021.06.024
	7XJH (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoproterenol	-		3.3	2022-05-04	doi.org/10.1016/j.molcel.2021.06.024
	9IJD	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-	chim(NtGi1-Gs)/β1/γ2	2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJD (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-		2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJE	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-	chim(NtGi1-Gs)/β1/γ2	2.34	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJE (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-		2.34	2024-08-21	doi.org/10.1002/cplu.202400288

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