psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:A40	R:R:L99	4.73	No	Yes	0	4	5
2	R:R:A95	R:R:L44	3.15	No	No	4	6	8
3	R:R:L44	R:R:W333	3.42	No	Yes	4	8	5
4	R:R:E47	R:R:V91	5.7	No	Yes	0	7	7
5	R:R:E47	R:R:W333	8.72	No	Yes	0	7	5
6	R:R:V48	R:R:V91	3.21	No	Yes	1	6	7
7	R:R:P92	R:R:V48	3.53	No	No	1	8	6
8	R:R:G87	R:R:T51	3.64	No	No	0	8	7
9	R:R:A340	R:R:T51	3.36	No	No	0	6	7
10	R:R:A80	R:R:N55	3.13	No	Yes	0	9	9
11	R:R:D83	R:R:N55	6.73	Yes	Yes	0	9	9
12	R:R:L84	R:R:N55	6.87	No	Yes	0	8	9
13	R:R:N55	R:R:P343	6.52	Yes	No	0	9	9
14	R:R:L56	R:R:L84	5.54	No	No	0	4	8
15	R:R:F356	R:R:L57	10.96	No	No	0	7	7
16	R:R:L360	R:R:L57	6.92	No	No	0	7	7
17	R:R:A80	R:R:V58	3.39	No	No	0	9	9
18	R:R:C347	R:R:V58	6.83	No	No	0	7	9
19	R:R:A80	R:R:I59	3.25	No	No	0	9	7
20	R:R:I59	R:R:T81	4.56	No	No	0	7	6
21	R:R:I62	R:R:L68	4.28	Yes	Yes	2	7	8
22	R:R:I62	R:R:N73	8.5	Yes	Yes	2	7	9
23	R:R:I62	R:R:T77	4.56	Yes	No	0	7	6
24	R:R:F352	R:R:I62	3.77	Yes	Yes	2	8	7
25	R:R:P66	R:R:T65	3.5	No	No	0	6	6
26	R:R:R67	R:R:T65	3.88	No	No	0	5	6
27	R:R:L68	R:R:T65	5.9	Yes	No	0	8	6
28	R:R:L68	R:R:N73	4.12	Yes	Yes	2	8	9
29	R:R:D351	R:R:L68	5.43	No	Yes	2	7	8
30	R:R:F352	R:R:L68	6.09	Yes	Yes	2	8	8
31	R:R:T70	R:R:T72	3.14	No	No	0	8	8
32	R:R:N73	R:R:T70	5.85	Yes	No	0	9	8
33	R:R:M71	R:R:Y145	4.79	No	Yes	0	6	7
34	R:R:D134	R:R:T72	10.12	No	No	0	9	8
35	R:R:F352	R:R:N73	6.04	Yes	Yes	2	8	9
36	R:R:F75	R:R:V74	3.93	Yes	No	0	8	5
37	R:R:A130	R:R:F75	4.16	No	Yes	0	7	8
38	R:R:D134	R:R:F75	5.97	No	Yes	0	9	8
39	R:R:S78	R:R:T127	4.8	No	No	0	9	8
40	R:R:S78	R:R:V158	4.85	No	No	0	9	7
41	R:R:S78	R:R:W162	6.18	No	Yes	0	9	9
42	R:R:D83	R:R:L79	5.43	Yes	Yes	3	9	9
43	R:R:L79	R:R:T127	4.42	Yes	No	0	9	8
44	R:R:L128	R:R:L79	5.54	No	Yes	3	8	9
45	R:R:L79	R:R:N342	5.49	Yes	Yes	3	9	9
46	R:R:D83	R:R:S124	5.89	Yes	No	0	9	9
47	R:R:D83	R:R:S339	7.36	Yes	No	0	9	9
48	R:R:D83	R:R:N342	8.08	Yes	Yes	3	9	9
49	R:R:C120	R:R:V85	3.42	No	No	0	6	7
50	R:R:G87	R:R:V86	3.68	No	No	0	8	8
51	R:R:S339	R:R:V86	4.85	No	No	0	9	8
52	R:R:G87	R:R:V91	3.68	No	Yes	0	8	7
53	R:R:L88	R:R:L89	5.54	No	No	0	4	5
54	R:R:V90	R:R:W113	4.9	No	Yes	1	7	5
55	R:R:D117	R:R:V90	11.69	Yes	No	1	7	7
56	R:R:V90	R:R:Y336	5.05	No	Yes	1	7	7
57	R:R:P92	R:R:V91	3.53	No	Yes	1	8	7
58	R:R:V91	R:R:Y336	3.79	Yes	Yes	1	7	7
59	R:R:P92	R:R:P93	7.79	No	No	0	8	5
60	R:R:P93	R:R:W113	8.11	No	Yes	0	5	5
61	R:R:G94	R:R:W113	5.63	No	Yes	0	7	5
62	R:R:A95	R:R:W333	9.08	No	Yes	4	6	5
63	R:R:L97	R:R:W103	5.69	No	Yes	0	5	7
64	R:R:A98	R:R:L329	4.73	No	No	0	5	4
65	R:R:P104	R:R:W103	6.76	No	Yes	1	3	7
66	R:R:L105	R:R:W103	5.69	Yes	Yes	1	6	7
67	R:R:C110	R:R:W103	5.22	No	Yes	1	9	7
68	R:R:W103	R:R:W113	10.31	Yes	Yes	1	7	5
69	R:R:C196	R:R:W103	7.84	No	Yes	1	9	7
70	R:R:L105	R:R:P104	3.28	Yes	No	1	6	3
71	R:R:G109	R:R:L105	3.42	No	Yes	0	4	6
72	R:R:A107	R:R:N192	6.25	No	No	0	5	4
73	R:R:C110	R:R:C196	7.28	No	No	1	9	9
74	R:R:E111	R:R:P172	3.14	No	No	0	6	7
75	R:R:E111	R:R:I173	5.47	No	No	0	6	7
76	R:R:C196	R:R:W113	3.92	No	Yes	1	9	5
77	L:L:?1	R:R:W113	6.48	Yes	Yes	1	0	5
78	L:L:?1	R:R:T114	3.6	Yes	No	0	0	5
79	R:R:F170	R:R:S115	5.28	No	No	6	4	6
80	R:R:I173	R:R:S115	4.64	No	No	6	7	6
81	R:R:D117	R:R:V121	4.38	Yes	No	1	7	7
82	R:R:D117	R:R:Y336	10.34	Yes	Yes	1	7	7
83	L:L:?1	R:R:D117	20.97	Yes	Yes	1	0	7
84	R:R:S169	R:R:V118	6.46	No	No	0	7	7
85	L:L:?1	R:R:V118	9.69	Yes	No	0	0	7
86	R:R:C120	R:R:L119	4.76	No	No	0	6	5
87	R:R:L119	R:R:W162	4.56	No	Yes	0	5	9
88	R:R:V121	R:R:W305	8.58	No	Yes	1	7	8
89	L:L:?1	R:R:V121	9.69	Yes	No	1	0	7
90	R:R:S165	R:R:T122	3.2	No	No	0	8	7
91	R:R:T122	R:R:V168	4.76	No	No	0	7	6
92	R:R:S212	R:R:T122	9.59	No	No	0	6	7
93	R:R:A123	R:R:W162	7.78	No	Yes	5	8	9
94	R:R:A123	R:R:S165	3.42	No	No	5	8	8
95	R:R:I125	R:R:P216	3.39	No	Yes	0	8	9
96	R:R:F301	R:R:I125	5.02	Yes	No	0	9	8
97	R:R:I125	R:R:W305	8.22	No	Yes	0	8	8
98	R:R:E126	R:R:P216	6.29	No	Yes	0	5	9
99	R:R:L128	R:R:N342	5.49	No	Yes	3	8	9
100	R:R:L128	R:R:Y346	5.86	No	No	0	8	9
101	R:R:C129	R:R:V219	5.12	No	No	0	7	6
102	R:R:L131	R:R:Y346	5.86	No	No	0	8	9
103	R:R:A132	R:R:Y224	5.34	No	Yes	0	8	9
104	R:R:D134	R:R:Y145	5.75	No	Yes	0	9	7
105	R:R:R135	R:R:Y224	5.14	No	Yes	0	9	9
106	R:R:R135	R:R:Y346	6.17	No	No	0	9	9
107	R:R:L137	R:R:Y136	3.52	No	Yes	0	5	8
108	R:R:T140	R:R:Y136	17.48	No	Yes	0	6	8
109	R:R:V223	R:R:Y136	8.83	No	Yes	0	6	8
110	R:R:R226	R:R:Y136	12.35	No	Yes	0	6	8
111	R:R:A138	R:R:Y145	9.34	No	Yes	0	8	7
112	R:R:T140	R:R:V139	3.17	No	No	0	6	9
113	R:R:V139	R:R:V227	3.21	No	No	0	9	9
114	R:R:V139	R:R:V230	3.21	No	No	0	9	6
115	R:R:N141	R:R:R144	7.23	No	No	0	5	6
116	R:R:V149	R:R:Y145	7.57	No	Yes	0	6	7
117	R:R:R153	R:R:T150	10.35	No	No	0	7	8
118	R:R:K151	R:R:R155	7.43	No	No	0	4	5
119	R:R:A156	R:R:R152	4.15	No	No	0	2	5
120	R:R:S165	R:R:W162	3.71	No	Yes	5	8	9
121	R:R:F170	R:R:I173	7.54	No	No	6	4	7
122	R:R:P172	R:R:Y204	5.56	No	Yes	0	7	8
123	R:R:E185	R:R:R188	3.49	No	No	0	2	2
124	R:R:C189	R:R:E185	6.08	No	No	0	1	2
125	R:R:C189	R:R:C195	7.28	No	No	0	1	4
126	R:R:A197	R:R:C189	3.61	No	No	0	4	1
127	R:R:P193	R:R:S191	3.56	No	No	0	2	1
128	R:R:C195	R:R:P193	5.65	No	No	0	4	2
129	R:R:F198	R:R:S200	7.93	No	No	0	5	4
130	R:R:F198	R:R:N312	9.67	No	No	0	5	7
131	L:L:?1	R:R:F198	12.88	Yes	No	0	0	5
132	R:R:S200	R:R:Y204	5.09	No	Yes	0	4	8
133	R:R:N201	R:R:P203	8.15	No	No	0	6	4
134	R:R:N201	R:R:Y204	5.81	No	Yes	0	6	8
135	R:R:I202	R:R:P203	5.08	No	No	0	4	4
136	R:R:S208	R:R:Y204	7.63	No	Yes	0	6	8
137	R:R:L206	R:R:L317	4.15	No	No	7	6	4
138	L:L:?1	R:R:S208	9.77	Yes	No	0	0	6
139	R:R:F309	R:R:S209	5.28	Yes	No	0	7	7
140	R:R:N312	R:R:S209	4.47	No	No	0	7	7
141	R:R:S209	R:R:V313	3.23	No	Yes	0	7	6
142	R:R:S210	R:R:V211	3.23	No	No	0	4	4
143	L:L:?1	R:R:S212	7.33	Yes	No	0	0	6
144	R:R:F213	R:R:Y214	5.16	Yes	No	0	8	6
145	R:R:F213	R:R:L217	7.31	Yes	No	1	8	6
146	R:R:F213	R:R:F301	5.36	Yes	Yes	1	8	9
147	R:R:F213	R:R:L306	7.31	Yes	Yes	0	8	6
148	R:R:F213	R:R:F309	20.36	Yes	Yes	1	8	7
149	R:R:V313	R:R:Y214	6.31	Yes	No	0	6	6
150	R:R:L217	R:R:L221	4.15	No	No	0	6	5
151	R:R:F301	R:R:L217	4.87	Yes	No	1	9	6
152	R:R:M220	R:R:Y224	4.79	No	Yes	0	8	9
153	R:R:F301	R:R:M220	7.46	Yes	No	0	9	8
154	R:R:F222	R:R:R226	6.41	No	No	0	5	6
155	R:R:L294	R:R:Y224	5.86	No	Yes	0	8	9
156	R:R:I297	R:R:Y224	3.63	No	Yes	0	9	9
157	R:R:V298	R:R:Y224	5.05	No	Yes	0	8	9
158	R:R:F228	R:R:T232	7.78	No	No	0	6	5
159	R:R:F228	R:R:L291	7.31	No	No	0	6	8
160	R:R:F228	R:R:L294	3.65	No	No	0	6	8
161	R:R:L235	R:R:R239	3.64	No	No	0	5	5
162	R:R:E241	R:R:R240	13.96	No	No	8	2	4
163	R:R:R240	R:R:R244	5.33	No	No	8	4	5
164	R:R:E241	R:R:R244	10.47	No	No	8	2	5
165	R:R:F245	R:R:R244	4.28	No	No	0	1	5
166	R:R:E287	R:R:R292	10.47	No	No	0	8	8
167	R:R:H288	R:R:L291	11.57	No	No	0	5	8
168	R:R:H288	R:R:R292	9.03	No	No	0	5	8
169	R:R:R289	R:R:R292	3.2	No	No	0	8	8
170	R:R:R348	R:R:T293	6.47	No	No	0	7	8
171	R:R:I345	R:R:L296	5.71	Yes	No	0	8	7
172	R:R:I345	R:R:T300	4.56	Yes	No	0	8	6
173	R:R:L306	R:R:T302	4.42	Yes	No	0	6	6
174	R:R:C304	R:R:N338	9.45	No	No	0	9	9
175	R:R:F308	R:R:W305	7.02	Yes	Yes	1	7	8
176	R:R:F309	R:R:W305	8.02	Yes	Yes	1	7	8
177	R:R:G335	R:R:W305	9.85	No	Yes	0	8	8
178	R:R:N338	R:R:W305	9.04	No	Yes	0	9	8
179	R:R:L306	R:R:P307	3.28	Yes	No	0	6	9
180	R:R:L331	R:R:P307	3.28	No	No	0	6	9
181	R:R:F308	R:R:F309	11.79	Yes	Yes	1	7	7
182	R:R:F308	R:R:N312	4.83	Yes	No	0	7	7
183	R:R:F308	R:R:L331	3.65	Yes	No	0	7	6
184	R:R:F308	R:R:N332	16.92	Yes	No	1	7	6
185	L:L:?1	R:R:F308	6.93	Yes	Yes	1	0	7
186	L:L:?1	R:R:F309	5.94	Yes	Yes	1	0	7
187	R:R:A311	R:R:V323	3.39	No	No	0	5	3
188	R:R:P320	R:R:R315	7.21	No	No	0	1	4
189	R:R:L328	R:R:R315	6.07	No	No	0	5	4
190	R:R:G319	R:R:P320	4.06	No	No	0	2	1
191	R:R:P324	R:R:V323	3.53	No	No	0	4	3
192	R:R:P324	R:R:P326	5.84	No	No	0	4	1
193	R:R:A327	R:R:P324	3.74	No	No	0	4	4
194	R:R:P326	R:R:S325	5.34	No	No	0	1	2
195	R:R:N332	R:R:Y336	5.81	No	Yes	1	6	7
196	L:L:?1	R:R:N332	11.17	Yes	No	1	0	6
197	R:R:N338	R:R:N342	4.09	No	Yes	0	9	9
198	R:R:C347	R:R:F352	15.36	No	Yes	0	7	8
199	R:R:P350	R:R:S349	3.56	No	No	0	5	8
200	R:R:D351	R:R:S349	7.36	No	No	2	7	8
201	R:R:F352	R:R:S349	6.61	Yes	No	2	8	8
202	R:R:D351	R:R:F352	5.97	No	Yes	2	7	8
203	R:R:R353	R:R:R357	5.33	No	No	0	9	4
204	R:R:L84	R:R:V52	2.98	No	No	0	8	5
205	R:R:L131	R:R:V76	2.98	No	No	0	8	8
206	R:R:L89	R:R:V85	2.98	No	No	0	5	7
207	R:R:L137	R:R:V133	2.98	No	No	0	5	6
208	R:R:L160	R:R:V164	2.98	No	No	0	3	5
209	R:R:L206	R:R:V313	2.98	No	Yes	7	6	6
210	R:R:L306	R:R:V310	2.98	Yes	No	0	6	6
211	R:R:L317	R:R:V313	2.98	No	Yes	7	4	6
212	R:R:L328	R:R:V323	2.98	No	No	0	5	3
213	R:R:I297	R:R:I345	2.94	No	Yes	0	9	8
214	R:R:A199	R:R:H190	2.93	No	No	0	4	1
215	R:R:E126	R:R:V161	2.85	No	No	0	5	7
216	R:R:L359	R:R:L57	2.77	No	No	0	5	7
217	R:R:A61	R:R:F356	2.77	No	No	0	8	7
218	R:R:A63	R:R:R64	2.77	No	No	0	1	5
219	R:R:A154	R:R:F75	2.77	No	Yes	0	7	8
220	R:R:A157	R:R:F75	2.77	No	Yes	0	6	8
221	R:R:L329	R:R:L97	2.77	No	No	0	4	5
222	R:R:L137	R:R:L148	2.77	No	No	0	5	5
223	R:R:A166	R:R:F170	2.77	No	No	0	4	4
224	R:R:L238	R:R:L242	2.77	No	No	0	4	4
225	R:R:A171	R:R:Y204	2.67	No	Yes	0	6	8
226	R:R:A82	R:R:W162	2.59	No	Yes	0	8	9
227	R:R:S210	R:R:Y214	2.54	No	No	0	4	6
228	R:R:L237	R:R:R240	2.43	No	No	0	5	4
229	R:R:L99	R:R:W333	2.28	Yes	Yes	0	5	5
230	R:R:F352	R:R:F356	2.14	Yes	No	0	8	7
231	R:R:R233	R:R:R236	2.13	No	No	0	5	6
232	R:R:R348	R:R:R353	2.13	No	No	0	7	9
233	R:R:G53	R:R:G54	2.11	No	No	0	4	8
234	R:R:G318	R:R:G319	2.11	No	No	9	4	2
235	R:R:G54	R:R:P343	2.03	No	No	0	8	9
236	R:R:C129	R:R:P216	1.88	No	Yes	0	7	9
237	R:R:G109	R:R:T108	1.82	No	No	0	4	1
238	R:R:A205	R:R:A316	1.79	No	No	0	6	6
239	R:R:A231	R:R:A290	1.79	No	No	0	8	8
240	R:R:P104	R:R:T96	1.75	No	No	0	3	5
241	R:R:G41	R:R:L44	1.71	No	No	0	6	8
242	R:R:G41	R:R:L99	1.71	No	Yes	0	6	5
243	R:R:G106	R:R:L105	1.71	No	Yes	0	7	6
244	R:R:C120	R:R:V116	1.71	No	No	0	6	6
245	R:R:C129	R:R:V133	1.71	No	No	0	7	6
246	R:R:G318	R:R:L322	1.71	No	No	9	4	1
247	R:R:G319	R:R:L322	1.71	No	No	9	2	1
248	R:R:L215	R:R:P216	1.64	No	Yes	0	5	9
249	R:R:L334	R:R:P307	1.64	No	No	0	7	9
250	R:R:N141	R:R:P142	1.63	No	No	0	5	8
251	R:R:A316	R:R:I202	1.62	No	No	0	6	4
252	R:R:V159	R:R:V163	1.6	No	No	0	4	4
253	R:R:C304	R:R:L303	1.59	No	No	0	9	5
254	R:R:A355	R:R:L68	1.58	No	Yes	0	8	8
255	R:R:A311	R:R:L331	1.58	No	No	0	5	6
256	R:R:T100	R:R:T96	1.57	No	No	0	5	5
257	R:R:K151	R:R:V74	1.52	No	No	0	4	5
258	R:R:I297	R:R:T293	1.52	No	No	0	9	8
259	R:R:G101	R:R:R102	1.5	No	No	0	4	3
260	R:R:L99	R:R:V37	1.49	Yes	No	0	5	4
261	R:R:L49	R:R:V52	1.49	No	No	0	5	5
262	R:R:L359	R:R:V60	1.49	No	No	0	5	5
263	R:R:G146	R:R:Y145	1.45	No	Yes	0	6	7
264	R:R:F245	R:R:P246	1.44	No	No	0	1	3
265	R:R:I345	R:R:L344	1.43	Yes	No	0	8	6
266	R:R:C195	R:R:R102	1.39	No	No	0	4	3
267	R:R:A337	R:R:F341	1.39	No	No	0	4	6
268	R:R:L148	R:R:N141	1.37	No	No	0	5	5
269	R:R:K151	R:R:Q69	1.36	No	No	0	4	7
270	R:R:R357	R:R:S354	1.32	No	No	0	4	4
271	R:R:R358	R:R:S354	1.32	No	No	0	5	4
272	R:R:R64	R:R:V60	1.31	No	No	0	5	5
273	R:R:R233	R:R:V230	1.31	No	No	0	5	6
274	R:R:R152	R:R:T150	1.29	No	No	0	5	8
275	R:R:H194	R:R:N192	1.28	No	No	0	3	4
276	R:R:F341	R:R:L344	1.22	No	No	0	6	6
277	R:R:Q187	R:R:R188	1.17	No	No	0	1	2
278	R:R:Q234	R:R:R233	1.17	No	No	0	7	5
279	R:R:E185	R:R:R315	1.16	No	No	0	2	4
280	R:R:H194	R:R:R102	1.13	No	No	0	3	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	R:R:N55	5.8125	4	0	9
2	R:R:I62	5.2775	4	2	7
3	R:R:L68	4.56667	6	2	8
4	R:R:N73	6.1275	4	2	9
5	R:R:F75	3.92	5	0	8
6	R:R:L79	5.22	4	3	9
7	R:R:D83	6.698	5	3	9
8	R:R:V91	3.982	5	1	7
9	R:R:L99	2.5525	4	0	5
10	R:R:W103	6.91833	6	1	7
11	R:R:L105	3.525	4	1	6
12	R:R:W113	6.55833	6	1	5
13	R:R:D117	11.845	4	1	7
14	R:R:Y136	10.545	4	0	8
15	R:R:Y145	5.78	5	0	7
16	R:R:W162	4.964	5	5	9
17	R:R:Y204	5.352	5	0	8
18	R:R:F213	9.1	5	1	8
19	R:R:P216	3.3	4	0	9
20	R:R:Y224	4.96833	6	0	9
21	R:R:F301	5.6775	4	1	9
22	R:R:W305	8.455	6	1	8
23	R:R:L306	4.4975	4	0	6
24	R:R:F308	8.52333	6	1	7
25	R:R:F309	10.278	5	1	7
26	R:R:V313	3.875	4	7	6
27	R:R:W333	5.875	4	4	5
28	R:R:Y336	6.2475	4	1	7
29	R:R:N342	5.7875	4	3	9
30	R:R:I345	3.66	4	0	8
31	R:R:F352	6.56857	7	2	8
32	L:L:?1	9.49545	11	1	0

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	R:R:L99	R:R:W333	11.8766	2.28	Yes	Yes	0	5	5
2	R:R:E47	R:R:W333	24.2825	8.72	No	Yes	0	7	5
3	R:R:E47	R:R:V91	27.3266	5.7	No	Yes	0	7	7
4	R:R:G87	R:R:V91	13.4369	3.68	No	Yes	0	8	7
5	R:R:G87	R:R:V86	11.0755	3.68	No	No	0	8	8
6	R:R:S339	R:R:V86	11.0476	4.85	No	No	0	9	8
7	R:R:D83	R:R:S339	12.2736	7.36	Yes	No	0	9	9
8	R:R:D83	R:R:N55	100	6.73	Yes	Yes	0	9	9
9	R:R:A80	R:R:N55	85.9571	3.13	No	Yes	0	9	9
10	R:R:A80	R:R:V58	80.4611	3.39	No	No	0	9	9
11	R:R:C347	R:R:V58	78.6013	6.83	No	No	0	7	9
12	R:R:C347	R:R:F352	76.7275	15.36	No	Yes	0	7	8
13	R:R:F352	R:R:F356	18.6055	2.14	Yes	No	0	8	7
14	R:R:F356	R:R:L57	14.0359	10.96	No	No	0	7	7
15	R:R:F352	R:R:L68	11.0337	6.09	Yes	Yes	2	8	8
16	R:R:F352	R:R:N73	37.6498	6.04	Yes	Yes	2	8	9
17	R:R:N73	R:R:T70	36.4377	5.85	Yes	No	0	9	8
18	R:R:T70	R:R:T72	34.2644	3.14	No	No	0	8	8
19	R:R:D134	R:R:T72	32.0772	10.12	No	No	0	9	8
20	R:R:D134	R:R:Y145	11.7651	5.75	No	Yes	0	9	7
21	R:R:D134	R:R:F75	18.6612	5.97	No	Yes	0	9	8
22	R:R:D83	R:R:L79	18.5915	5.43	Yes	Yes	3	9	9
23	R:R:L79	R:R:T127	13.1095	4.42	Yes	No	0	9	8
24	R:R:S78	R:R:T127	11.4029	4.8	No	No	0	9	8
25	R:R:V91	R:R:Y336	33.7768	3.79	Yes	Yes	1	7	7
26	R:R:D117	R:R:Y336	12.8309	10.34	Yes	Yes	1	7	7
27	L:L:?1	R:R:S212	21.336	7.33	Yes	No	0	0	6
28	R:R:S212	R:R:T122	18.5846	9.59	No	No	0	6	7
29	R:R:S165	R:R:T122	16.3625	3.2	No	No	0	8	7
30	R:R:S165	R:R:W162	14.0011	3.71	No	Yes	5	8	9
31	R:R:N332	R:R:Y336	21.0504	5.81	No	Yes	1	6	7
32	R:R:L128	R:R:L79	15.046	5.54	No	Yes	3	8	9
33	R:R:D83	R:R:N342	82.8434	8.08	Yes	Yes	3	9	9
34	R:R:L128	R:R:N342	18.3059	5.49	No	Yes	3	8	9
35	R:R:L119	R:R:W162	13.3672	4.56	No	Yes	0	5	9
36	R:R:C120	R:R:L119	11.173	4.76	No	No	0	6	5
37	R:R:W103	R:R:W113	34.1878	10.31	Yes	Yes	1	7	5
38	R:R:L105	R:R:W103	11.584	5.69	Yes	Yes	1	6	7
39	R:R:C195	R:R:R102	10.4416	1.39	No	No	0	4	3
40	R:R:C189	R:R:C195	16.5436	7.28	No	No	0	1	4
41	R:R:C189	R:R:E185	20.5419	6.08	No	No	0	1	2
42	R:R:E185	R:R:R315	26.3374	1.16	No	No	0	2	4
43	R:R:L328	R:R:R315	35.8805	6.07	No	No	0	5	4
44	R:R:L328	R:R:V323	37.7473	2.98	No	No	0	5	3
45	R:R:A311	R:R:V323	46.8724	3.39	No	No	0	5	3
46	R:R:A311	R:R:L331	48.6556	1.58	No	No	0	5	6
47	R:R:F308	R:R:L331	46.3709	3.65	Yes	No	0	7	6
48	R:R:F308	R:R:N332	14.9902	16.92	Yes	No	1	7	6
49	L:L:?1	R:R:S208	40.1087	9.77	Yes	No	0	0	6
50	R:R:S208	R:R:Y204	37.3154	7.63	No	Yes	0	6	8
51	R:R:P172	R:R:Y204	17.7487	5.56	No	Yes	0	7	8
52	R:R:E111	R:R:P172	14.8091	3.14	No	No	0	6	7
53	R:R:E111	R:R:I173	11.9462	5.47	No	No	0	6	7
54	R:R:V121	R:R:W305	33.338	8.58	No	Yes	1	7	8
55	R:R:F308	R:R:W305	57.119	7.02	Yes	Yes	1	7	8
56	R:R:I125	R:R:W305	63.1583	8.22	No	Yes	0	8	8
57	R:R:I125	R:R:P216	55.2522	3.39	No	Yes	0	8	9
58	R:R:F301	R:R:I125	20.3539	5.02	Yes	No	0	9	8
59	L:L:?1	R:R:F309	47.3252	5.94	Yes	Yes	1	0	7
60	R:R:F213	R:R:F309	33.6932	20.36	Yes	Yes	1	8	7
61	R:R:F213	R:R:F301	30.8651	5.36	Yes	Yes	1	8	9
62	R:R:F308	R:R:F309	11.4586	11.79	Yes	Yes	1	7	7
63	R:R:L128	R:R:Y346	31.1368	5.86	No	No	0	8	9
64	R:R:C129	R:R:P216	46.141	1.88	No	Yes	0	7	9
65	R:R:M220	R:R:Y224	43.1875	4.79	No	Yes	0	8	9
66	R:R:F301	R:R:M220	44.3787	7.46	Yes	No	0	9	8
67	R:R:C129	R:R:V133	41.5018	1.71	No	No	0	7	6
68	R:R:L137	R:R:V133	39.1613	2.98	No	No	0	5	6
69	R:R:L137	R:R:Y136	27.2499	3.52	No	Yes	0	5	8
70	R:R:T140	R:R:Y136	17.47	17.48	No	Yes	0	6	8
71	R:R:T140	R:R:V139	14.9902	3.17	No	No	0	6	9
72	R:R:L137	R:R:L148	10.163	2.77	No	No	0	5	5
73	R:R:N201	R:R:Y204	14.8997	5.81	No	Yes	0	6	8
74	R:R:N201	R:R:P203	11.9462	8.15	No	No	0	6	4
75	R:R:F213	R:R:L306	11.9044	7.31	Yes	Yes	0	8	6
76	R:R:L294	R:R:Y224	21.8933	5.86	No	Yes	0	8	9
77	R:R:I297	R:R:Y224	34.9053	3.63	No	Yes	0	9	9
78	R:R:F228	R:R:L294	19.2045	3.65	No	No	0	6	8
79	R:R:F228	R:R:L291	13.7852	7.31	No	No	0	6	8
80	R:R:H288	R:R:L291	11.0546	11.57	No	No	0	5	8
81	R:R:I297	R:R:T293	16.2789	1.52	No	No	0	9	8
82	R:R:I297	R:R:I345	16.5018	2.94	No	Yes	0	9	8
83	R:R:N338	R:R:W305	86.4865	9.04	No	Yes	0	9	8
84	R:R:R348	R:R:T293	13.5623	6.47	No	No	0	7	8
85	R:R:R348	R:R:R353	11.0546	2.13	No	No	0	7	9
86	R:R:R135	R:R:Y346	25.3901	6.17	No	No	0	9	9
87	L:L:?1	R:R:W113	45.319	6.48	Yes	Yes	1	0	5
88	R:R:S78	R:R:W162	10.358	6.18	No	Yes	0	9	9
89	L:L:?1	R:R:F308	36.988	6.93	Yes	Yes	1	0	7
90	L:L:?1	R:R:V121	25.9125	9.69	Yes	No	1	0	7
91	R:R:F309	R:R:W305	32.5021	8.02	Yes	Yes	1	7	8
92	R:R:R135	R:R:Y224	25.5224	5.14	No	Yes	0	9	9
93	R:R:N338	R:R:N342	83.2265	4.09	No	Yes	0	9	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
R:R:V90	R:R:W113	4.9	1	No	Yes	7	5	2	1
R:R:D117	R:R:V90	11.69	1	Yes	No	7	7	1	2
R:R:V90	R:R:Y336	5.05	1	No	Yes	7	7	2	2
R:R:P93	R:R:W113	8.11	0	No	Yes	5	5	2	1
R:R:G94	R:R:W113	5.63	0	No	Yes	7	5	2	1
R:R:W103	R:R:W113	10.31	1	Yes	Yes	7	5	2	1
R:R:C196	R:R:W103	7.84	1	No	Yes	9	7	2	2
R:R:C196	R:R:W113	3.92	1	No	Yes	9	5	2	1
L:L:?1	R:R:W113	6.48	1	Yes	Yes	0	5	0	1
L:L:?1	R:R:T114	3.6	1	Yes	No	0	5	0	1
R:R:D117	R:R:V121	4.38	1	Yes	No	7	7	1	1
R:R:D117	R:R:Y336	10.34	1	Yes	Yes	7	7	1	2
L:L:?1	R:R:D117	20.97	1	Yes	Yes	0	7	0	1
R:R:S169	R:R:V118	6.46	0	No	No	7	7	2	1
L:L:?1	R:R:V118	9.69	1	Yes	No	0	7	0	1
R:R:V121	R:R:W305	8.58	1	No	Yes	7	8	1	2
L:L:?1	R:R:V121	9.69	1	Yes	No	0	7	0	1
R:R:S212	R:R:T122	9.59	0	No	No	6	7	1	2
R:R:F198	R:R:S200	7.93	0	No	No	5	4	1	2
R:R:F198	R:R:N312	9.67	0	No	No	5	7	1	2
L:L:?1	R:R:F198	12.88	1	Yes	No	0	5	0	1
R:R:S200	R:R:Y204	5.09	0	No	Yes	4	8	2	2
R:R:S208	R:R:Y204	7.63	0	No	Yes	6	8	1	2
L:L:?1	R:R:S208	9.77	1	Yes	No	0	6	0	1
R:R:F309	R:R:S209	5.28	1	Yes	No	7	7	1	2
R:R:N312	R:R:S209	4.47	0	No	No	7	7	2	2
L:L:?1	R:R:S212	7.33	1	Yes	No	0	6	0	1
R:R:F213	R:R:F309	20.36	1	Yes	Yes	8	7	2	1
R:R:F308	R:R:W305	7.02	1	Yes	Yes	7	8	1	2
R:R:F309	R:R:W305	8.02	1	Yes	Yes	7	8	1	2
R:R:F308	R:R:F309	11.79	1	Yes	Yes	7	7	1	1
R:R:F308	R:R:N312	4.83	1	Yes	No	7	7	1	2
R:R:F308	R:R:L331	3.65	1	Yes	No	7	6	1	2
R:R:F308	R:R:N332	16.92	1	Yes	No	7	6	1	1
L:L:?1	R:R:F308	6.93	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F309	5.94	1	Yes	Yes	0	7	0	1
R:R:N332	R:R:Y336	5.81	1	No	Yes	6	7	1	2
L:L:?1	R:R:N332	11.17	1	Yes	No	0	6	0	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	7XJH_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.13
Number of Linked Nodes	252
Number of Links	280
Number of Hubs	32
Number of Links mediated by Hubs	133
Number of Communities	9
Number of Nodes involved in Communities	49
Number of Links involved in Communities	66

Path Summary
Number Of Nodes in MetaPath	94
Number Of Links MetaPath	93
Number of Shortest Paths	41960
Length Of Smallest Path	3
Average Path Length	12.6993
Length of Longest Path	30
Minimum Path Strength	1.205
Average Path Strength	5.99888
Maximum Path Strength	16.3567
Minimum Path Correlation	0.7
Average Path Correlation	0.935335
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4.54545
Average % Of Corr. Nodes	57.0812
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	41.0245
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• identical protein binding • protein binding • binding • protein homodimerization activity • protein dimerization activity • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • neurotransmitter receptor activity • G protein-coupled serotonin receptor activity • beta3-adrenergic receptor activity • cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction
Gene Ontology	Biological Process	• cellular response to stimulus • positive regulation of cell communication • regulation of cellular process • positive regulation of signal transduction • response to stimulus • signaling • positive regulation of biological process • regulation of signal transduction • intracellular signal transduction • cell communication • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • signal transduction • positive regulation of cellular process • regulation of biological process • regulation of signaling • positive regulation of MAPK cascade • biological regulation • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • cellular process • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • trans-synaptic signaling • synaptic signaling • anterograde trans-synaptic signaling • cell-cell signaling • chemical synaptic transmission • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • protein-containing complex • receptor complex • cellular anatomical structure • synapse • cell junction • cell periphery • plasma membrane • membrane • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • protein binding • binding • G-protein beta-subunit binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • catalytic activity • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • cytoskeletal protein binding • spectrin binding • protein-containing complex binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to stress • response to hypoxia • response to stress • response to oxygen levels • response to abiotic stimulus • cell population proliferation • phospholipase C-activating G protein-coupled receptor signaling pathway • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • photoreceptor inner segment • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • cell body • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • ion binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • small molecule binding • D1 dopamine receptor binding • signaling receptor binding • G protein-coupled receptor binding • dopamine receptor binding • G-protein beta/gamma-subunit complex binding • G protein activity • molecular function regulator activity • enzyme regulator activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function activator activity • adenylate cyclase regulator activity • adenylate cyclase activator activity • cation binding • metal ion binding • epithelium development • ectodermal placode morphogenesis • epidermis development • molting cycle process • hair cycle • hair follicle placode formation • tissue development • ectodermal placode formation • anatomical structure morphogenesis • skin development • skin epidermis development • hair follicle development • molting cycle • anatomical structure formation involved in morphogenesis • ectodermal placode development • hair cycle process • sensory perception of smell • response to peptide hormone • cellular response to peptide hormone stimulus • response to glucagon • cellular response to glucagon stimulus • skeletal system development • bone development • regulation of body fluid levels • wound healing • homotypic cell-cell adhesion • cell activation • hemostasis • platelet aggregation • blood coagulation • cell adhesion • cell-cell adhesion • coagulation • response to wounding • platelet activation • response to fluid shear stress • vascular endothelial cell response to laminar fluid shear stress • response to laminar fluid shear stress • cellular response to laminar fluid shear stress • vascular endothelial cell response to fluid shear stress • cellular response to fluid shear stress • cognition • developmental growth • growth • homeostatic process • adaptive thermogenesis • positive regulation of metabolic process • multicellular organismal-level homeostasis • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • metabolic process • regulation of multicellular organismal process • regulation of metabolic process • regulation of localization • establishment of protein localization • nitrogen compound transport • regulation of hormone secretion • regulation of protein localization • regulation of peptide secretion • transport • hormone secretion • protein localization to extracellular region • localization • peptide secretion • regulation of secretion by cell • secretion by cell • amide transport • signal release • intracellular protein localization • regulation of peptide hormone secretion • regulation of transport • secretion • regulation of hormone levels • regulation of peptide transport • regulation of establishment of protein localization • establishment of protein localization to extracellular region • export from cell • regulation of protein transport • protein secretion • establishment of localization • regulation of protein secretion • regulation of secretion • peptide transport • protein transport • regulation of insulin secretion • peptide hormone secretion • macromolecule localization • hormone transport • insulin secretion • cellular localization • establishment of localization in cell • intracellular transport • regulation of defense response • regulation of response to external stimulus • negative regulation of inflammatory response • negative regulation of biological process • inflammatory response to antigenic stimulus • regulation of response to stress • regulation of immune system process • negative regulation of inflammatory response to antigenic stimulus • defense response • immune response • negative regulation of response to stimulus • negative regulation of immune response • regulation of inflammatory response to antigenic stimulus • response to external stimulus • regulation of inflammatory response • negative regulation of immune system process • immune system process • negative regulation of response to external stimulus • negative regulation of defense response • regulation of immune response • inflammatory response • positive regulation of adenylate cyclase activity • positive regulation of molecular function • regulation of molecular function • positive regulation of cyclase activity • activation of adenylate cyclase activity • regulation of adenylate cyclase activity • regulation of catalytic activity • positive regulation of catalytic activity • positive regulation of lyase activity • renal system process • chemical homeostasis • multicellular organismal-level water homeostasis • multicellular organismal-level chemical homeostasis • renal water homeostasis • extracellular exosome • extracellular vesicle • extracellular organelle • extracellular region • extracellular space • vesicle • extracellular membrane-bounded organelle • cytosol • Golgi apparatus subcompartment • Golgi apparatus • organelle subcompartment • trans-Golgi network membrane • intracellular membrane-bounded organelle • endomembrane system • intracellular organelle • trans-Golgi network
Gene Ontology	Cellular Component
SCOP2	Domain Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• G protein-coupled receptor-like • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	5FW
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	5FW
Name	ISOPRENALINE
Synonyms
Identifier
Formula	C11 H17 N O3
Molecular Weight	211.258
SMILES
PubChem	443372
Formal Charge	0
Total Atoms	32
Total Chiral Atoms	1
Total Bonds	32
Total Aromatic Bonds	6


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	O02662
Sequence	>7XJH_nogp_Chain_R A V A L A G A L L A L E V L A T V G G N L L V I V A I A R T P R L Q T M T N V F V T S L A T A D L V V G L L V V P P G A T L A L T G R W P L G A T G C E L W T S V D V L C V T A S I E T L C A L A V D R Y L A V T N P L R Y G A L V T K R R A R A A V V L V W V V S A A V S F A P I M S E A Q R C H S N P H C C A F A S N I P Y A L L S S S V S F Y L P L L V M L F V Y A R V F L V A T R Q L R L L R R E L G R F P E H R A L R T L G L I V G T F T L C W L P F F V A N V M R A L G G P S L V P S P A L L A L N W L G Y A N S A F N P L I Y C R S P D F R S A F R R L L Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	7XJI	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-	Gs/β1/γ2	3.9	2022-05-04	doi.org/10.1016/j.bbrc.2022.04.065
	7XJI (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-		3.9	2022-05-04	doi.org/10.1016/j.bbrc.2022.04.065
	7DH5	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-	Gs/β1/γ2	3.16	2021-08-04	doi.org/10.1016/j.molcel.2021.06.024
	7DH5 (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-		3.16	2021-08-04	doi.org/10.1016/j.molcel.2021.06.024
	7XJH	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoproterenol	-	Gs/β1/γ2	3.3	2022-05-04	doi.org/10.1016/j.molcel.2021.06.024
	7XJH (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoproterenol	-		3.3	2022-05-04	doi.org/10.1016/j.molcel.2021.06.024
	9IJD	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-	chim(NtGi1-Gs)/β1/γ2	2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJD (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-		2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJE	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-	chim(NtGi1-Gs)/β1/γ2	2.34	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJE (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-		2.34	2024-08-21	doi.org/10.1002/cplu.202400288

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