psnGPCR

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Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:D117	11.22	Yes	Yes	1	0	8
2	L:L:?1	R:R:V118	12.31	Yes	No	0	0	7
3	L:L:?1	R:R:V121	8.21	Yes	No	0	0	6
4	L:L:?1	R:R:V205	5.13	Yes	Yes	1	0	6
5	L:L:?1	R:R:S208	10.34	Yes	No	0	0	6
6	L:L:?1	R:R:S212	4.14	Yes	No	0	0	6
7	L:L:?1	R:R:F308	9.23	Yes	Yes	1	0	7
8	L:L:?1	R:R:F309	10.9	Yes	Yes	1	0	7
9	L:L:?1	R:R:N312	16.08	Yes	Yes	1	0	7
10	L:L:?1	R:R:N332	13.24	Yes	No	1	0	7
11	L:L:?1	R:R:Y336	3.23	Yes	Yes	1	0	8
12	R:R:A95	R:R:L44	3.15	No	No	0	6	7
13	R:R:L44	R:R:W333	19.36	No	No	0	7	6
14	R:R:V48	R:R:V91	3.21	No	No	0	6	8
15	R:R:P92	R:R:V48	3.53	No	No	0	8	6
16	R:R:G87	R:R:T51	3.64	No	No	0	7	7
17	R:R:A340	R:R:T51	3.36	No	No	0	6	7
18	R:R:L88	R:R:V52	5.96	No	No	0	5	6
19	R:R:A80	R:R:N55	3.13	No	Yes	0	9	9
20	R:R:D83	R:R:N55	10.77	Yes	Yes	0	9	9
21	R:R:N55	R:R:P343	11.4	Yes	No	0	9	9
22	R:R:F356	R:R:L57	4.87	No	No	0	8	8
23	R:R:A80	R:R:V58	3.39	No	No	0	9	9
24	R:R:C347	R:R:V58	5.12	No	No	0	7	9
25	R:R:A80	R:R:I59	3.25	No	No	0	9	7
26	R:R:V60	R:R:W64	4.9	No	No	0	4	5
27	R:R:I62	R:R:N73	15.58	No	Yes	2	8	9
28	R:R:F352	R:R:I62	5.02	Yes	No	2	9	8
29	R:R:P66	R:R:T65	3.5	No	No	0	6	6
30	R:R:L68	R:R:T65	10.32	Yes	No	0	8	6
31	R:R:D351	R:R:R67	23.82	No	No	0	7	5
32	R:R:R67	R:R:S354	3.95	No	No	0	5	5
33	R:R:L68	R:R:N73	5.49	Yes	Yes	2	8	9
34	R:R:D351	R:R:L68	9.5	No	Yes	0	7	8
35	R:R:F352	R:R:L68	3.65	Yes	Yes	2	9	8
36	R:R:A355	R:R:L68	3.15	No	Yes	0	8	8
37	R:R:T70	R:R:T72	3.14	No	No	0	7	8
38	R:R:N73	R:R:T70	5.85	Yes	No	0	9	7
39	R:R:M71	R:R:Y145	4.79	No	Yes	3	6	8
40	R:R:M71	R:R:V149	6.09	No	Yes	3	6	7
41	R:R:D134	R:R:T72	8.67	No	No	0	9	8
42	R:R:N73	R:R:V76	7.39	Yes	No	0	9	8
43	R:R:F352	R:R:N73	9.67	Yes	Yes	2	9	9
44	R:R:A154	R:R:V74	3.39	No	No	0	7	5
45	R:R:R155	R:R:V74	3.92	No	No	0	4	5
46	R:R:A130	R:R:F75	4.16	No	No	0	7	8
47	R:R:D134	R:R:F75	3.58	No	No	0	9	8
48	R:R:S78	R:R:T127	7.99	No	No	0	9	8
49	R:R:S78	R:R:V158	8.08	No	No	0	9	7
50	R:R:S78	R:R:W162	4.94	No	Yes	0	9	9
51	R:R:D83	R:R:L79	6.79	Yes	No	1	9	9
52	R:R:L128	R:R:L79	5.54	Yes	No	1	9	9
53	R:R:L79	R:R:N342	9.61	No	Yes	1	9	9
54	R:R:D83	R:R:S339	7.36	Yes	No	0	9	9
55	R:R:D83	R:R:N342	9.42	Yes	Yes	1	9	9
56	R:R:L84	R:R:L88	4.15	No	No	0	7	5
57	R:R:C120	R:R:V85	6.83	Yes	No	0	7	6
58	R:R:M86	R:R:V90	9.13	Yes	Yes	1	7	7
59	R:R:C120	R:R:M86	3.24	Yes	Yes	0	7	7
60	R:R:M86	R:R:Y336	3.59	Yes	Yes	1	7	8
61	R:R:M86	R:R:S339	6.13	Yes	No	0	7	9
62	R:R:V90	R:R:V91	3.21	Yes	No	1	7	8
63	R:R:D117	R:R:V90	10.22	Yes	Yes	1	8	7
64	R:R:V90	R:R:Y336	5.05	Yes	Yes	1	7	8
65	R:R:V91	R:R:Y336	6.31	No	Yes	1	8	8
66	R:R:P92	R:R:P93	5.84	No	No	0	8	6
67	R:R:L105	R:R:P93	9.85	Yes	No	1	5	6
68	R:R:P93	R:R:W113	10.81	No	Yes	1	6	6
69	R:R:A94	R:R:W333	3.89	No	No	0	6	6
70	R:R:P104	R:R:T96	10.49	No	No	0	3	4
71	R:R:L97	R:R:W103	5.69	No	No	0	4	8
72	R:R:H102	R:R:T100	6.85	No	No	0	3	5
73	R:R:L105	R:R:P104	3.28	Yes	No	0	5	3
74	R:R:L105	R:R:W113	5.69	Yes	Yes	1	5	6
75	R:R:C110	R:R:E111	4.56	No	No	0	9	6
76	R:R:T114	R:R:W113	3.64	No	Yes	0	5	6
77	R:R:D117	R:R:W113	21.22	Yes	Yes	1	8	6
78	R:R:S115	R:R:S169	3.26	No	No	0	6	8
79	R:R:F170	R:R:S115	7.93	No	No	0	5	6
80	R:R:D117	R:R:Y336	4.6	Yes	Yes	1	8	8
81	R:R:S169	R:R:V118	8.08	No	No	0	8	7
82	R:R:C120	R:R:L119	3.17	Yes	No	0	7	6
83	R:R:L119	R:R:W162	4.56	No	Yes	0	6	9
84	R:R:V121	R:R:W305	13.48	No	Yes	0	6	8
85	R:R:S165	R:R:T122	6.4	No	No	0	8	7
86	R:R:S212	R:R:T122	9.59	No	No	0	6	7
87	R:R:A123	R:R:W162	9.08	No	Yes	0	8	9
88	R:R:A123	R:R:S165	3.42	No	No	0	8	8
89	R:R:I125	R:R:P216	3.39	No	Yes	1	8	9
90	R:R:F301	R:R:I125	5.02	Yes	No	1	9	8
91	R:R:I125	R:R:W305	3.52	No	Yes	1	8	8
92	R:R:C129	R:R:W126	3.92	Yes	Yes	1	7	6
93	R:R:V161	R:R:W126	3.68	No	Yes	0	7	6
94	R:R:L215	R:R:W126	4.56	No	Yes	1	6	6
95	R:R:P216	R:R:W126	10.81	Yes	Yes	1	9	6
96	R:R:F301	R:R:L128	4.87	Yes	Yes	1	9	9
97	R:R:L128	R:R:N342	6.87	Yes	Yes	1	9	9
98	R:R:L128	R:R:Y346	5.86	Yes	Yes	0	9	9
99	R:R:C129	R:R:P216	3.77	Yes	Yes	1	7	9
100	R:R:C129	R:R:V219	3.42	Yes	No	0	7	6
101	R:R:C129	R:R:M220	4.86	Yes	Yes	0	7	8
102	R:R:L131	R:R:Y346	5.86	No	Yes	0	9	9
103	R:R:A132	R:R:M220	3.22	No	Yes	0	9	8
104	R:R:A132	R:R:Y224	6.67	No	Yes	0	9	9
105	R:R:D134	R:R:Y145	6.9	No	Yes	0	9	8
106	R:R:R135	R:R:Y224	4.12	No	Yes	0	9	9
107	R:R:R135	R:R:Y346	5.14	No	Yes	0	9	9
108	R:R:L137	R:R:Y136	3.52	No	Yes	0	5	8
109	R:R:T140	R:R:Y136	14.98	No	Yes	0	6	8
110	R:R:V223	R:R:Y136	7.57	No	Yes	0	7	8
111	R:R:R226	R:R:Y136	7.2	No	Yes	0	6	8
112	R:R:L137	R:R:L148	6.92	No	No	0	5	5
113	R:R:A138	R:R:Y145	9.34	No	Yes	0	8	8
114	R:R:V139	R:R:V230	3.21	No	No	0	9	7
115	R:R:N141	R:R:T140	5.85	No	No	0	6	6
116	R:R:V149	R:R:Y145	3.79	Yes	Yes	3	7	8
117	R:R:C153	R:R:V149	5.12	No	Yes	0	6	7
118	R:R:K151	R:R:R155	8.66	No	No	0	4	4
119	R:R:S208	R:R:V168	3.23	No	No	0	6	6
120	R:R:P172	R:R:Y204	9.74	No	No	0	9	8
121	R:R:M202	R:R:P203	3.35	No	No	0	4	3
122	R:R:S208	R:R:Y204	8.9	No	No	0	6	8
123	R:R:N312	R:R:V205	5.91	Yes	Yes	1	7	6
124	R:R:A316	R:R:V205	3.39	No	Yes	0	6	6
125	R:R:L206	R:R:L317	5.54	No	No	4	5	5
126	R:R:F309	R:R:S209	5.28	Yes	No	0	7	6
127	R:R:N312	R:R:S209	5.96	Yes	No	0	7	6
128	R:R:F213	R:R:Y214	14.44	Yes	No	0	8	5
129	R:R:F213	R:R:L217	7.31	Yes	No	1	8	5
130	R:R:F213	R:R:F301	7.5	Yes	Yes	1	8	9
131	R:R:F213	R:R:L306	7.31	Yes	No	0	8	7
132	R:R:F213	R:R:F309	21.43	Yes	Yes	1	8	7
133	R:R:L310	R:R:Y214	4.69	No	No	0	6	5
134	R:R:L215	R:R:P216	3.28	No	Yes	1	6	9
135	R:R:F301	R:R:L217	6.09	Yes	No	1	9	5
136	R:R:M220	R:R:M298	4.33	Yes	No	0	8	8
137	R:R:F301	R:R:M220	4.98	Yes	Yes	0	9	8
138	R:R:L221	R:R:M298	4.24	No	No	0	5	8
139	R:R:F222	R:R:R226	12.83	No	No	0	4	6
140	R:R:L294	R:R:Y224	7.03	No	Yes	0	8	9
141	R:R:I297	R:R:Y224	7.25	No	Yes	0	8	9
142	R:R:M298	R:R:Y224	3.59	No	Yes	0	8	9
143	R:R:F228	R:R:T232	9.08	Yes	No	0	6	5
144	R:R:F228	R:R:L291	3.65	Yes	No	0	6	7
145	R:R:F228	R:R:L294	3.65	Yes	No	0	6	8
146	R:R:R233	R:R:V230	6.54	No	No	0	4	7
147	R:R:L235	R:R:R239	4.86	No	No	0	6	4
148	R:R:L237	R:R:R236	4.86	No	No	0	5	5
149	R:R:E241	R:R:R244	9.3	No	No	0	4	4
150	R:R:F245	R:R:R244	9.62	No	No	0	2	4
151	R:R:L291	R:R:R289	13.36	No	No	0	7	8
152	R:R:C292	R:R:R289	4.18	No	No	0	7	8
153	R:R:R348	R:R:T293	10.35	No	No	0	7	9
154	R:R:I345	R:R:L296	4.28	No	No	0	8	7
155	R:R:L296	R:R:R348	6.07	No	No	0	7	7
156	R:R:I297	R:R:Y346	3.63	No	Yes	0	8	9
157	R:R:F301	R:R:W305	4.01	Yes	Yes	1	9	8
158	R:R:L306	R:R:T302	4.42	No	No	0	7	6
159	R:R:C304	R:R:N338	9.45	No	Yes	0	8	9
160	R:R:F308	R:R:W305	7.02	Yes	Yes	1	7	8
161	R:R:F309	R:R:W305	7.02	Yes	Yes	1	7	8
162	R:R:G335	R:R:W305	11.26	No	Yes	0	7	8
163	R:R:N338	R:R:W305	9.04	Yes	Yes	0	9	8
164	R:R:L306	R:R:P307	3.28	No	No	0	7	9
165	R:R:F308	R:R:F309	9.65	Yes	Yes	1	7	7
166	R:R:F308	R:R:N312	3.62	Yes	Yes	1	7	7
167	R:R:F308	R:R:F328	9.65	Yes	Yes	1	7	5
168	R:R:F308	R:R:N332	12.08	Yes	No	1	7	7
169	R:R:F328	R:R:N312	6.04	Yes	Yes	1	5	7
170	R:R:R315	R:R:V323	5.23	No	Yes	0	5	4
171	R:R:F328	R:R:R315	19.24	Yes	No	0	5	5
172	R:R:G319	R:R:P320	4.06	No	No	0	1	2
173	R:R:P324	R:R:V323	3.53	No	Yes	0	4	4
174	R:R:P324	R:R:P326	3.9	No	No	0	4	2
175	R:R:A327	R:R:P324	3.74	No	No	0	5	4
176	R:R:G325	R:R:P326	4.06	No	No	0	2	2
177	R:R:N332	R:R:Y336	11.63	No	Yes	1	7	8
178	R:R:W333	R:R:Y336	3.86	No	Yes	0	6	8
179	R:R:N338	R:R:N342	6.81	Yes	Yes	0	9	9
180	R:R:I345	R:R:Y346	9.67	No	Yes	0	8	9
181	R:R:C347	R:R:F352	18.15	No	Yes	0	7	9
182	R:R:P350	R:R:S349	5.34	No	No	0	6	9
183	R:R:F352	R:R:F356	9.65	Yes	No	0	9	8
184	R:R:R358	R:R:R362	4.26	No	No	0	5	2
185	R:R:I59	R:R:T77	3.04	No	No	0	7	6
186	R:R:L49	R:R:V48	2.98	No	No	0	5	6
187	R:R:L359	R:R:V60	2.98	No	No	0	6	4
188	R:R:L89	R:R:V85	2.98	No	No	0	5	6
189	R:R:L137	R:R:V133	2.98	No	No	0	5	6
190	R:R:L148	R:R:V149	2.98	No	Yes	0	5	7
191	R:R:L160	R:R:V164	2.98	No	No	0	2	5
192	R:R:L206	R:R:V313	2.98	No	No	4	5	5
193	R:R:L207	R:R:V211	2.98	No	No	0	5	4
194	R:R:L317	R:R:V313	2.98	No	No	4	5	5
195	R:R:L322	R:R:V323	2.98	No	Yes	0	4	4
196	R:R:N55	R:R:T51	2.92	Yes	No	0	9	7
197	R:R:N338	R:R:T300	2.92	Yes	No	0	9	6
198	R:R:P320	R:R:R315	2.88	No	No	0	2	5
199	R:R:L206	R:R:M202	2.83	No	No	0	5	4
200	R:R:L56	R:R:L84	2.77	No	No	0	4	7
201	R:R:A61	R:R:F356	2.77	No	No	0	7	8
202	R:R:A157	R:R:F75	2.77	No	No	0	6	8
203	R:R:A290	R:R:F228	2.77	No	Yes	0	8	6
204	R:R:L238	R:R:L242	2.77	No	No	0	6	3
205	R:R:A311	R:R:F328	2.77	No	Yes	0	5	5
206	R:R:L237	R:R:Q234	2.66	No	No	0	5	7
207	R:R:R357	R:R:S354	2.64	No	No	0	4	5
208	R:R:A82	R:R:W162	2.59	No	Yes	0	8	9
209	R:R:V227	R:R:Y136	2.52	No	Yes	0	9	8
210	R:R:V313	R:R:Y214	2.52	No	No	0	5	5
211	R:R:F308	R:R:L331	2.44	Yes	No	0	7	6
212	R:R:N141	R:R:R144	2.41	No	No	0	6	6
213	R:R:R233	R:R:R236	2.13	No	No	0	4	5
214	R:R:G53	R:R:G54	2.11	No	No	0	3	8
215	R:R:G318	R:R:G319	2.11	No	No	0	4	1
216	R:R:G54	R:R:P343	2.03	No	No	0	8	9
217	R:R:A171	R:R:P172	1.87	No	No	0	4	9
218	R:R:G53	R:R:V52	1.84	No	No	0	3	6
219	R:R:G87	R:R:V52	1.84	No	No	0	7	6
220	R:R:G109	R:R:T108	1.82	No	No	0	5	3
221	R:R:G299	R:R:T302	1.82	No	No	0	6	6
222	R:R:A231	R:R:A290	1.79	No	No	0	8	8
223	R:R:A82	R:R:S124	1.71	No	No	0	8	9
224	R:R:G106	R:R:L105	1.71	No	Yes	0	7	5
225	R:R:G109	R:R:L112	1.71	No	No	0	5	5
226	R:R:C120	R:R:V116	1.71	Yes	No	0	7	5
227	R:R:G325	R:R:L329	1.71	No	No	0	2	4
228	R:R:C110	R:R:T114	1.69	No	No	0	9	5
229	R:R:C153	R:R:T150	1.69	No	No	0	6	8
230	R:R:L97	R:R:P104	1.64	No	No	0	4	3
231	R:R:L334	R:R:P307	1.64	No	No	0	7	9
232	R:R:N141	R:R:P142	1.63	No	No	0	6	9
233	R:R:A81	R:R:I59	1.62	No	No	0	5	7
234	R:R:A154	R:R:M71	1.61	No	No	0	7	6
235	R:R:V139	R:R:V227	1.6	No	No	0	9	9
236	R:R:V159	R:R:V163	1.6	No	No	0	3	4
237	R:R:V164	R:R:V168	1.6	No	No	0	5	6
238	R:R:V168	R:R:V211	1.6	No	No	0	6	4
239	R:R:V229	R:R:V230	1.6	No	No	0	5	7
240	R:R:A98	R:R:L44	1.58	No	No	0	5	7
241	R:R:P66	R:R:Q69	1.58	No	No	0	6	8
242	R:R:A166	R:R:L119	1.58	No	No	0	3	6
243	R:R:T100	R:R:T96	1.57	No	No	0	5	4
244	R:R:I173	R:R:S115	1.55	No	No	0	6	6
245	R:R:L314	R:R:V323	1.49	No	Yes	0	5	4
246	R:R:N201	R:R:V205	1.48	No	Yes	0	6	6
247	R:R:L359	R:R:T65	1.47	No	No	0	6	6
248	R:R:D351	R:R:S349	1.47	No	No	0	7	9
249	R:R:G146	R:R:Y145	1.45	No	Yes	0	5	8
250	R:R:I345	R:R:L344	1.43	No	No	0	8	7
251	R:R:A337	R:R:F341	1.39	No	No	0	5	5
252	R:R:C361	R:R:R357	1.39	No	No	0	3	4
253	R:R:L43	R:R:L46	1.38	No	No	0	4	4
254	R:R:L218	R:R:L221	1.38	No	No	0	3	5
255	R:R:A63	R:R:W64	1.3	No	No	0	3	5
256	R:R:F341	R:R:T300	1.3	No	No	0	5	6
257	R:R:R152	R:R:T150	1.29	No	No	0	4	8
258	R:R:R152	R:R:T156	1.29	No	No	0	4	3

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: hub id, click on each number to highlight the corresponding hub in the 3D visualization.

Hub: the hub being considered.

Avg Int. Strength: the average interaction strength of all the links of the corresponding hub.

Num Of Links: the number of links of the corresponding hub.

Community: the id of the community the link belong to, otherwise 0.

ConSurf: this column reports the ConSurf conservation grades of each hub.

Index	Hub	Avg Int. Strength	Num Of Links	Community	ConSurf
1	L:L:?1	9.45727	11	1	0
2	R:R:N55	7.055	4	0	9
3	R:R:L68	6.422	5	2	8
4	R:R:N73	8.796	5	2	9
5	R:R:D83	8.585	4	1	9
6	R:R:M86	5.5225	4	1	7
7	R:R:V90	6.9025	4	1	7
8	R:R:L105	5.1325	4	1	5
9	R:R:W113	10.34	4	1	6
10	R:R:D117	11.815	4	1	8
11	R:R:C120	3.7375	4	0	7
12	R:R:W126	5.7425	4	1	6
13	R:R:L128	5.785	4	1	9
14	R:R:C129	3.9925	4	1	7
15	R:R:Y136	7.158	5	0	8
16	R:R:Y145	5.254	5	3	8
17	R:R:V149	4.495	4	3	7
18	R:R:W162	5.2925	4	0	9
19	R:R:V205	3.9775	4	1	6
20	R:R:F213	11.598	5	1	8
21	R:R:P216	5.3125	4	1	9
22	R:R:M220	4.3475	4	0	8
23	R:R:Y224	5.732	5	0	9
24	R:R:F228	4.7875	4	0	6
25	R:R:F301	5.41167	6	1	9
26	R:R:W305	7.90714	7	1	8
27	R:R:F308	7.67	7	1	7
28	R:R:F309	10.856	5	1	7
29	R:R:N312	7.522	5	1	7
30	R:R:V323	3.3075	4	0	4
31	R:R:F328	9.425	4	1	5
32	R:R:Y336	5.46714	7	1	8
33	R:R:N338	7.055	4	0	9
34	R:R:N342	8.1775	4	1	9
35	R:R:Y346	6.032	5	0	9
36	R:R:F352	9.228	5	2	9

Color	ConSurf Grade
	No Conservation data available
	1
	2
	3
	4
	5
	6
	7
	8
	9

Index: link id, click on each number to highlight the corresponding link in the 3D visualization.

Node1 Node2: the two nodes of the corresponding link.

Recurrence: the relative Recurrence in the pool of shortest paths.

Int. Strength: the interaction strength between the two nodes.

Hub1?, Hub2?: "Yes" if the corresponding node has more than 3 links, otherwise "No".

Community: the id of the community the link belong to, otherwise 0.

ConSurf1, ConSurf2: these columns report the ConSurf conservation grades of the two nodes involved in a link.

Index	Node1	Node2	Recurrence	Int. Strength	Hub1?	Hub2?	Community	ConSurf1	ConSurf2
1	L:L:?1	R:R:Y336	34.1725	3.23	Yes	Yes	1	0	8
2	R:R:W333	R:R:Y336	12.3319	3.86	No	Yes	0	6	8
3	L:L:?1	R:R:D117	22.7187	11.22	Yes	Yes	1	0	8
4	R:R:D117	R:R:W113	34.6449	21.22	Yes	Yes	1	8	6
5	R:R:M86	R:R:Y336	35.962	3.59	Yes	Yes	1	7	8
6	R:R:M86	R:R:S339	44.5593	6.13	Yes	No	0	7	9
7	R:R:D83	R:R:S339	44.9094	7.36	Yes	No	0	9	9
8	R:R:D83	R:R:N55	100	10.77	Yes	Yes	0	9	9
9	R:R:N55	R:R:T51	11.6539	2.92	Yes	No	0	9	7
10	R:R:A80	R:R:N55	89.9744	3.13	No	Yes	0	9	9
11	R:R:A80	R:R:V58	85.9953	3.39	No	No	0	9	9
12	R:R:C347	R:R:V58	84.9728	5.12	No	No	0	7	9
13	R:R:C347	R:R:F352	83.9391	18.15	No	Yes	0	7	9
14	R:R:F352	R:R:L68	22.363	3.65	Yes	Yes	2	9	8
15	R:R:L68	R:R:T65	11.6483	10.32	Yes	No	0	8	6
16	R:R:F352	R:R:N73	55.9964	9.67	Yes	Yes	2	9	9
17	R:R:D351	R:R:L68	11.7817	9.5	No	Yes	0	7	8
18	R:R:N73	R:R:T70	57.208	5.85	Yes	No	0	9	7
19	R:R:T70	R:R:T72	55.9075	3.14	No	No	0	7	8
20	R:R:D134	R:R:T72	54.596	8.67	No	No	0	9	8
21	R:R:D134	R:R:Y145	49.2275	6.9	No	Yes	0	9	8
22	R:R:V149	R:R:Y145	37.318	3.79	Yes	Yes	3	7	8
23	L:L:?1	R:R:S212	11.8929	4.14	Yes	No	0	0	6
24	R:R:C120	R:R:M86	25.2584	3.24	Yes	Yes	0	7	7
25	R:R:C120	R:R:L119	17.5003	3.17	Yes	No	0	7	6
26	R:R:L119	R:R:W162	13.5212	4.56	No	Yes	0	6	9
27	L:L:?1	R:R:V121	16.1721	8.21	Yes	No	0	0	6
28	R:R:V121	R:R:W305	16.5722	13.48	No	Yes	0	6	8
29	R:R:F301	R:R:W305	41.2137	4.01	Yes	Yes	1	9	8
30	R:R:F301	R:R:L128	41.4194	4.87	Yes	Yes	1	9	9
31	R:R:L128	R:R:L79	29.8266	5.54	Yes	No	1	9	9
32	L:L:?1	R:R:F308	21.3738	9.23	Yes	Yes	1	0	7
33	R:R:F308	R:R:W305	33.6612	7.02	Yes	Yes	1	7	8
34	L:L:?1	R:R:F309	32.4997	10.9	Yes	Yes	1	0	7
35	R:R:F309	R:R:W305	17.7059	7.02	Yes	Yes	1	7	8
36	R:R:F213	R:R:F309	18.7896	21.43	Yes	Yes	1	8	7
37	R:R:F213	R:R:F301	26.3366	7.5	Yes	Yes	1	8	9
38	R:R:N338	R:R:W305	19.9066	9.04	Yes	Yes	0	9	8
39	R:R:N338	R:R:N342	16.5722	6.81	Yes	Yes	0	9	9
40	R:R:D83	R:R:L79	29.7766	6.79	Yes	No	1	9	9
41	R:R:L105	R:R:W113	20.7125	5.69	Yes	Yes	1	5	6
42	R:R:L105	R:R:P104	15.7664	3.28	Yes	No	0	5	3
43	L:L:?1	R:R:V118	10.6869	12.31	Yes	No	0	0	7
44	R:R:I125	R:R:W305	12.3208	3.52	No	Yes	1	8	8
45	R:R:I125	R:R:P216	14.5993	3.39	No	Yes	1	8	9
46	R:R:F301	R:R:M220	48.5384	4.98	Yes	Yes	0	9	8
47	R:R:L128	R:R:Y346	42.9921	5.86	Yes	Yes	0	9	9
48	R:R:A132	R:R:M220	16.3165	3.22	No	Yes	0	9	8
49	R:R:A132	R:R:Y224	13.4434	6.67	No	Yes	0	9	9
50	R:R:M220	R:R:M298	22.3408	4.33	Yes	No	0	8	8
51	R:R:M298	R:R:Y224	13.7212	3.59	No	Yes	0	8	9
52	R:R:L148	R:R:V149	30.588	2.98	No	Yes	0	5	7
53	R:R:L137	R:R:L148	29.0764	6.92	No	No	0	5	5
54	R:R:L137	R:R:Y136	26.0198	3.52	No	Yes	0	5	8
55	R:R:V227	R:R:Y136	13.3489	2.52	No	Yes	0	9	8
56	R:R:V139	R:R:V227	11.7095	1.6	No	No	0	9	9
57	R:R:V139	R:R:V230	10.0589	3.21	No	No	0	9	7
58	L:L:?1	R:R:S208	18.8785	10.34	Yes	No	0	0	6
59	R:R:F213	R:R:Y214	12.443	14.44	Yes	No	0	8	5
60	R:R:L294	R:R:Y224	41.8306	7.03	No	Yes	0	8	9
61	R:R:I297	R:R:Y346	12.9599	3.63	No	Yes	0	8	9
62	R:R:F228	R:R:L294	36.64	3.65	Yes	No	0	6	8
63	R:R:F228	R:R:L291	15.7664	3.65	Yes	No	0	6	7
64	R:R:L291	R:R:R289	10.5202	13.36	No	No	0	7	8
65	R:R:I345	R:R:Y346	14.0769	9.67	No	Yes	0	8	9
66	R:R:F328	R:R:R315	21.0459	19.24	Yes	No	0	5	5
67	R:R:F308	R:R:F328	18.7229	9.65	Yes	Yes	1	7	5
68	R:R:R315	R:R:V323	14.3103	5.23	No	Yes	0	5	4
69	R:R:S208	R:R:V168	10.6813	3.23	No	No	0	6	6
70	R:R:A290	R:R:F228	10.5202	2.77	No	Yes	0	8	6
71	R:R:M86	R:R:V90	10.8314	9.13	Yes	Yes	1	7	7
72	R:R:D83	R:R:N342	44.1425	9.42	Yes	Yes	1	9	9
73	R:R:R135	R:R:Y346	12.5653	5.14	No	Yes	0	9	9
74	R:R:L128	R:R:N342	29.9822	6.87	Yes	Yes	1	9	9
75	R:R:R135	R:R:Y224	10.4702	4.12	No	Yes	0	9	9
76	R:R:I297	R:R:Y224	10.4702	7.25	No	Yes	0	8	9

Download PSN data

2D representation of the global metapath, ligand(s) interactions and
histograms of path distribution according to several parameters
(click on the image to enlarge it 🔍):

A 2D representation of the global communication in the network.

ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Number of shortest communication paths as a function of the average residue correlation.

Number of shortest communication paths as a function of the average interaction strength of their links.

Number of shortest communication paths as a function of the % of hub nodes in each path.

Number of shortest communication paths as a function of the number of nodes in each path.

Number of shortest communication paths as a function of the % of correlated nodes in each path.

2D representation of the interactions of this orthosteric/allosteric ligand.

Links and nodes colored according to ConSurf Conservation Grade (See documentation):

n/a 1 2 3 4 5 6 7 8 9

Node1	Node2	LinkStrength	Comm	IsNode1Hub?	IsNode2Hub?	Node1Cons	Node2Cons	Node1Shell	Node2Shell
L:L:?1	R:R:D117	11.22	1	Yes	Yes	0	8	0	1
L:L:?1	R:R:V118	12.31	1	Yes	No	0	7	0	1
L:L:?1	R:R:V121	8.21	1	Yes	No	0	6	0	1
L:L:?1	R:R:V205	5.13	1	Yes	Yes	0	6	0	1
L:L:?1	R:R:S208	10.34	1	Yes	No	0	6	0	1
L:L:?1	R:R:S212	4.14	1	Yes	No	0	6	0	1
L:L:?1	R:R:F308	9.23	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:F309	10.9	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N312	16.08	1	Yes	Yes	0	7	0	1
L:L:?1	R:R:N332	13.24	1	Yes	No	0	7	0	1
L:L:?1	R:R:Y336	3.23	1	Yes	Yes	0	8	0	1
R:R:M86	R:R:V90	9.13	1	Yes	Yes	7	7	2	2
R:R:M86	R:R:Y336	3.59	1	Yes	Yes	7	8	2	1
R:R:V90	R:R:V91	3.21	1	Yes	No	7	8	2	2
R:R:D117	R:R:V90	10.22	1	Yes	Yes	8	7	1	2
R:R:V90	R:R:Y336	5.05	1	Yes	Yes	7	8	2	1
R:R:V91	R:R:Y336	6.31	1	No	Yes	8	8	2	1
R:R:D117	R:R:W113	21.22	1	Yes	Yes	8	6	1	2
R:R:D117	R:R:Y336	4.6	1	Yes	Yes	8	8	1	1
R:R:S169	R:R:V118	8.08	0	No	No	8	7	2	1
R:R:V121	R:R:W305	13.48	0	No	Yes	6	8	1	2
R:R:S212	R:R:T122	9.59	0	No	No	6	7	1	2
R:R:S208	R:R:V168	3.23	0	No	No	6	6	1	2
R:R:S208	R:R:Y204	8.9	0	No	No	6	8	1	2
R:R:N312	R:R:V205	5.91	1	Yes	Yes	7	6	1	1
R:R:A316	R:R:V205	3.39	0	No	Yes	6	6	2	1
R:R:F309	R:R:S209	5.28	1	Yes	No	7	6	1	2
R:R:N312	R:R:S209	5.96	1	Yes	No	7	6	1	2
R:R:F213	R:R:F309	21.43	1	Yes	Yes	8	7	2	1
R:R:F308	R:R:W305	7.02	1	Yes	Yes	7	8	1	2
R:R:F309	R:R:W305	7.02	1	Yes	Yes	7	8	1	2
R:R:F308	R:R:F309	9.65	1	Yes	Yes	7	7	1	1
R:R:F308	R:R:N312	3.62	1	Yes	Yes	7	7	1	1
R:R:F308	R:R:F328	9.65	1	Yes	Yes	7	5	1	2
R:R:F308	R:R:N332	12.08	1	Yes	No	7	7	1	1
R:R:F328	R:R:N312	6.04	1	Yes	Yes	5	7	2	1
R:R:N332	R:R:Y336	11.63	1	No	Yes	7	8	1	1
R:R:W333	R:R:Y336	3.86	0	No	Yes	6	8	2	1
R:R:F308	R:R:L331	2.44	1	Yes	No	7	6	1	2
R:R:N201	R:R:V205	1.48	0	No	Yes	6	6	2	1

Location and physicochemical properties of the interaction partners of this ligand

Interactions of this ligand

Similarities between the interactions of this ligand and those of other networks

PDB Summary
PDB	9IJD_nogp
Class
SubFamily
Type
SubType
Species
Ligand
Other Ligand(s)
Protein Partners
PDB Resolution
Date
D.O.I.

Net Summary
I_min	3.13
Number of Linked Nodes	232
Number of Links	258
Number of Hubs	36
Number of Links mediated by Hubs	132
Number of Communities	4
Number of Nodes involved in Communities	38
Number of Links involved in Communities	57

Path Summary
Number Of Nodes in MetaPath	77
Number Of Links MetaPath	76
Number of Shortest Paths	43725
Length Of Smallest Path	3
Average Path Length	12.6615
Length of Longest Path	33
Minimum Path Strength	1.29
Average Path Strength	6.77544
Maximum Path Strength	17.935
Minimum Path Correlation	0.7
Average Path Correlation	0.924809
Maximum Path Correlation	0.99
Minimum % Of Corr. Nodes	4
Average % Of Corr. Nodes	49.9272
Maximum % Of Corr. Nodes	100
Minimum Path Hubs %	0
Average Path Hubs %	51.862
Maximum Path Hubs %	100

Annotation	Type	Links
Gene Ontology	Molecular Function	• cytoskeletal protein binding • spectrin binding • protein-containing complex binding • protein binding • binding • enzyme binding • GTPase binding • phosphoric ester hydrolase activity • alkylglycerophosphoethanolamine phosphodiesterase activity • hydrolase activity, acting on ester bonds • phosphoric diester hydrolase activity • hydrolase activity • catalytic activity • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity, acting on acid anhydrides • signaling receptor complex adaptor activity • protein-macromolecule adaptor activity • molecular adaptor activity • signaling adaptor activity • positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye
Gene Ontology	Biological Process	• positive regulation of cytosolic calcium ion concentration • biological regulation • regulation of biological quality • multicellular organismal process • system process • sensory perception of chemical stimulus • sensory perception • nervous system process • sensory perception of taste • developmental process • sensory organ development • eye development • animal organ development • retina development in camera-type eye • visual system development • multicellular organism development • camera-type eye development • anatomical structure development • sensory system development • system development • response to decreased oxygen levels • cellular response to stimulus • response to stimulus • cellular response to oxygen levels • cellular response to hypoxia • cellular response to decreased oxygen levels • cellular response to chemical stimulus • cellular response to stress • response to hypoxia • response to stress • response to chemical • response to oxygen levels • response to abiotic stimulus • cellular process • cell population proliferation • regulation of biological process • regulation of cellular process • signaling • phospholipase C-activating G protein-coupled receptor signaling pathway • cell communication • G protein-coupled receptor signaling pathway • signal transduction • muscle cell apoptotic process • striated muscle cell apoptotic process • apoptotic process • cell death • programmed cell death • cardiac muscle cell apoptotic process • protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex
Gene Ontology	Cellular Component	• protein-containing complex • extrinsic component of plasma membrane • catalytic complex • plasma membrane protein complex • cytoplasmic side of membrane • membrane • plasma membrane • membrane protein complex • heterotrimeric G-protein complex • side of membrane • cell periphery • cellular anatomical structure • cytoplasmic side of plasma membrane • GTPase complex • extrinsic component of membrane • extrinsic component of cytoplasmic side of plasma membrane • photoreceptor inner segment • somatodendritic compartment • cell projection • dendrite • dendritic tree • neuron projection • plasma membrane bounded cell projection • intracellular anatomical structure • cytoplasm • membrane-bounded organelle • non-motile cilium • 9+0 non-motile cilium • cilium • photoreceptor outer segment • photoreceptor cell cilium • organelle • ciliary membrane • photoreceptor outer segment membrane • bounding membrane of organelle • plasma membrane region • organelle membrane • cell projection membrane • synapse • cell junction • cell body • G protein-coupled amine receptor activity • molecular transducer activity • G protein-coupled receptor activity • transmembrane signaling receptor activity • signaling receptor activity • beta-adrenergic receptor activity • adrenergic receptor activity • beta-3 adrenergic receptor binding • protein binding • binding • adrenergic receptor binding • signaling receptor binding • G protein-coupled receptor binding • beta3-adrenergic receptor activity • identical protein binding • protein homodimerization activity • protein dimerization activity • cation binding • ion binding • catecholamine binding • norepinephrine binding • small molecule binding • epinephrine binding • hormone binding • multicellular organismal process • response to nutrient levels • response to stimulus • homeostatic process • adaptive thermogenesis • multicellular organismal-level homeostasis • response to dietary excess • diet induced thermogenesis • metabolic process • cellular process • energy homeostasis • response to stress • response to abiotic stimulus • response to cold • response to temperature stimulus • carbohydrate metabolic process • primary metabolic process • behavior • eating behavior • feeding behavior • cellular response to stimulus • regulation of biological process • regulation of cellular process • signaling • biological regulation • cell communication • adenylate cyclase-modulating G protein-coupled receptor signaling pathway • G protein-coupled receptor signaling pathway • signal transduction • generation of precursor metabolites and energy • energy derivation by oxidation of organic compounds • energy reserve metabolic process • developmental process • regulation of multicellular organism growth • regulation of growth • regulation of developmental growth • negative regulation of multicellular organism growth • regulation of developmental process • developmental growth • negative regulation of developmental process • growth • negative regulation of biological process • multicellular organism growth • negative regulation of developmental growth • negative regulation of growth • regulation of multicellular organismal process • negative regulation of multicellular organismal process • positive regulation of biological process • positive regulation of metabolic process • regulation of cold-induced thermogenesis • cold-induced thermogenesis • temperature homeostasis • positive regulation of cold-induced thermogenesis • positive regulation of multicellular organismal process • regulation of metabolic process • positive regulation of cellular process • positive regulation of cell communication • positive regulation of signal transduction • regulation of signal transduction • intracellular signal transduction • positive regulation of response to stimulus • regulation of intracellular signal transduction • intracellular signaling cassette • regulation of signaling • positive regulation of MAPK cascade • positive regulation of intracellular signal transduction • regulation of MAPK cascade • regulation of response to stimulus • MAPK cascade • regulation of cell communication • positive regulation of signaling • adenylate cyclase-activating adrenergic receptor signaling pathway • adenylate cyclase-activating G protein-coupled receptor signaling pathway • adrenergic receptor signaling pathway • fat cell differentiation • cellular developmental process • brown fat cell differentiation • cell differentiation • regulation of tube diameter • regulation of systemic arterial blood pressure mediated by a chemical signal • system process • regulation of blood pressure • regulation of tube size • norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure • negative regulation of blood pressure • regulation of systemic arterial blood pressure by norepinephrine-epinephrine • regulation of systemic arterial blood pressure • circulatory system process • negative regulation of systemic arterial blood pressure • vascular process in circulatory system • regulation of biological quality • blood vessel diameter maintenance • vasodilation • blood circulation • regulation of anatomical structure size • heat generation • G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger • receptor complex • peptide hormone receptor binding • corticotropin-releasing hormone receptor binding • corticotropin-releasing hormone receptor 1 binding • hormone receptor binding • neuropeptide receptor binding • mu-type opioid receptor binding • opioid receptor binding • beta-2 adrenergic receptor binding • D1 dopamine receptor binding • dopamine receptor binding • protein-containing complex binding • G-protein beta/gamma-subunit complex binding • ionotropic glutamate receptor binding • glutamate receptor binding • enzyme regulator activity • molecular function activator activity • phosphorus-oxygen lyase activity • cyclase regulator activity • enzyme activator activity • cyclase activator activity • molecular function regulator activity • cyclase activity • adenylate cyclase regulator activity • lyase activity • adenylate cyclase activator activity • catalytic activity • adenylate cyclase activity • guanyl nucleotide binding • GTP binding • nucleotide binding • guanyl ribonucleotide binding • purine ribonucleotide binding • purine ribonucleoside triphosphate binding • nucleoside phosphate binding • purine nucleotide binding • anion binding • heterocyclic compound binding • carbohydrate derivative binding • ribonucleotide binding • metal ion binding • pyrophosphatase activity • GTPase activity • ribonucleoside triphosphate phosphatase activity • hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides • hydrolase activity • hydrolase activity, acting on acid anhydrides • insulin-like growth factor receptor binding • sensory perception of chemical stimulus • sensory perception • nervous system process • cellular response to nitrogen compound • response to dopamine • cellular response to dopamine • response to monoamine • response to catecholamine • adenylate cyclase-activating dopamine receptor signaling pathway • cellular response to catecholamine stimulus • G protein-coupled dopamine receptor signaling pathway • response to oxygen-containing compound • response to nitrogen compound • cellular response to oxygen-containing compound • cellular response to chemical stimulus • cellular response to monoamine stimulus • response to chemical • G-protein beta-subunit binding • response to ketone • response to prostaglandin • response to lipid • response to endogenous stimulus • response to alcohol • cellular response to prostaglandin stimulus • cellular response to endogenous stimulus • cellular response to prostaglandin E stimulus • cellular response to alcohol • response to hormone • cellular response to lipid • response to prostaglandin E • cellular response to ketone • cellular response to hormone stimulus
SCOP2	Domain Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
SCOP2	Family Identifier	• Ras-like P-loop GTPases • Transducin (heterotrimeric G protein), gamma chain
Membrane Protein Annotations	-	• Orientations of Proteins in Membranes database (OPM) • Protein Data Bank of Transmembrane Proteins (PDBTM) • MemProtMD

Details about the values in these tables can be found in the corresponding documentation page .


Code	CAU
PDB Residues	L:L:?1
Environment Details	Open EMBL-EBI Page
Code	CAU
Name	(S)-carazolol
Synonyms	(S)-Carazolol
Identifier
Formula	C18 H22 N2 O2
Molecular Weight	298.379
SMILES
PubChem	13023332
Formal Charge	0
Total Atoms	44
Total Chiral Atoms	1
Total Bonds	46
Total Aromatic Bonds	15


PDBsum	Open PDBsum Page
Chain	R
Protein	Receptor
UniProt	P13945
Sequence	>9IJD_nogp_Chain_R A L L A L A V L A T V G G N L L V I V A I A W T P R L Q T M T N V F V T S L A A A D L V M G L L V V P P A A T L A L T G H W P L G A T G C E L W T S V D V L C V T A S I W T L C A L A V D R Y L A V T N P L R Y G A L V T K R C A R T A V V L V W V V S A A V S F A P I M N M P Y V L L S S S V S F Y L P L L V M L F V Y A R V F V V A T R Q L R L L R G E L G R F R A L C T L G L I M G T F T L C W L P F F L A N V L R A L G G P S L V P G P A F L A L N W L G Y A N S A F N P L I Y C R S P D F R S A F R R L L C R Click on each residue to open a popup with some information about it. ConSurf Conservation Grade (See documentation): n/a 1 2 3 4 5 6 7 8 9

This receptor, from the same or other species and bound to the same or other ligands, is also present in the following networks:
Show	PDB	Class	SubFamily	Type	SubType	Species	Orthosteric Ligand	Other Ligand(s)	Protein Partners	Resolution	Date	DOI
	9IJE	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-	chim(NtGi1-Gs)/β1/γ2	2.34	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJE (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Epinephrine	-		2.34	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJD	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-	chim(NtGi1-Gs)/β1/γ2	2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	9IJD (No Gprot)	A	Amine	Adrenergic	β₃	Homo sapiens	Carazolol	-		2.76	2024-08-21	doi.org/10.1002/cplu.202400288
	7XJI	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-	Gs/β1/γ2	3.9	2022-05-04	10.1016/j.bbrc.2022.04.065
	7XJI (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Solabegron	-		3.9	2022-05-04	10.1016/j.bbrc.2022.04.065
	7XJH	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoproterenol	-	Gs/β1/γ2	3.3	2022-05-04	10.1016/j.molcel.2021.06.024
	7XJH (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Isoproterenol	-		3.3	2022-05-04	10.1016/j.molcel.2021.06.024
	7DH5	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-	Gs/β1/γ2	3.16	2021-08-04	10.1016/j.molcel.2021.06.024
	7DH5 (No Gprot)	A	Amine	Adrenergic	β₃	Canis lupus familiaris	Mirabegron	-		3.16	2021-08-04	10.1016/j.molcel.2021.06.024

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